Paper

Org. Biomol. Chem., 2006, 4, 104 - 110, DOI: 10.1039/b513721g

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Rapid and efficient synthesis of poly-substituted quinolines assisted by p-toluene sulphonic acid under solvent-free conditions: comparative study of microwave irradiation versus conventional heating

Cheng-Sheng Jia, Ze Zhang, Shu-Jiang Tu and Guan-Wu Wang

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A rapid and efficient method for the preparation of various poly-substituted quinolines has been developed through the Friedländer condensation of 2-aminoarylketone or 2-aminoarylaldehyde with carbonyl compounds in the presence of p-toluene sulphonic acid, which was achieved by both microwave irradiation and conventional heating under solvent-free conditions.

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