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Org. Biomol. Chem., 2007, 5, 61 - 64, DOI: 10.1039/b613775j

A highly effective one-pot synthesis of quinolines from o-nitroarylcarbaldehydes

An-Hu Li, Eilaf Ahmed, Xin Chen, Matthew Cox, Andrew P. Crew, Han-Qing Dong, Meizhong Jin, Lifu Ma, Bijoy Panicker, Kam W. Siu, Arno G. Steinig, Kathryn M. Stolz, Paula A. R. Tavares, Brian Volk, Qinghua Weng, Doug Werner and Mark J. Mulvihill

A highly effective one-pot Friedländer quinoline synthesis using inexpensive reagents has been developed. o-Nitroarylcarbaldehydes were reduced to o-aminoarylcarbaldehydes with iron in the presence of catalytic HCl (aq.) and subsequently condensed in situ with aldehydes or ketones to form mono- or di-substituted quinolines in high yields (66–100%).

Graphical abstract image for this article (ID: b613775j)