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Paper

Org. Biomol. Chem., 2007, 5, 1562 - 1568, DOI: 10.1039/b703033a

Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor

Christopher D. Smith, Ian R. Baxendale, Geoffrey K. Tranmer, Marcus Baumann, Stephen C. Smith, Russell A. Lewthwaite and Steven V. Ley

The use of three orthogonally tagged phosphine reagents to assist chemical work-up via phase-switch scavenging in conjunction with a modular flow reactor is described. These techniques (acidic, basic and Click chemistry) are used to prepare various amides and tri-substituted guanidines from in situ generated iminophosphoranes.

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