Issue 12, 2008
From the journal:

Organic & Biomolecular Chemistry

Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata†

Kazuhiko Nakamura,*ab   Yu Tachikawa,b   Makoto Kitamura,ab   Osamu Ohno,b   Masami Suganumac  and  Daisuke Uemura*ab  

* Corresponding authors

a Department of Biosciences and Informatics, Keio University, 3-14-1 Hiyoshi, Yokohama 223-8522, Japan
E-mail: k_nakamura@bio.keio.ac.jp, uemura@bio.keio.ac.jp

b Graduate School of Science, Nagoya University, Furo-cho Chikusa, Nagoya 464-8602, Japan

c Research Institute for Clinical Oncology, Saitama Cancer Center, Ina, Kitaadachi-gun, Saitama 362-0806, Japan

Abstract

The marine fireworm, Eurythoe complanata, is known as a dangerous animal for humans because it induces skin inflammation through its small setae. Here, the inflammation-inducing substance was successfully isolated from the whole body using a methanolic extraction, and the inflammatory activity was determined using a bioassay. The structure was spectroscopically revealed to be a trimethylammonium with an unsaturated carbon chain and was named complanine. Complanine enhanced PKC activity in combination with TPA in vitro. This may explain the molecular mechanism behind its inflammation-inducing activity.

Graphical abstract: Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata

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Article information

DOI
https://doi.org/10.1039/B803107J
Article type
Communication
Submitted
22 Feb 2008
Accepted
15 Apr 2008
First published
24 Apr 2008

Org. Biomol. Chem., 2008,6, 2058-2060

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Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata

K. Nakamura, Y. Tachikawa, M. Kitamura, O. Ohno, M. Suganuma and D. Uemura, Org. Biomol. Chem., 2008, 6, 2058 DOI: 10.1039/B803107J

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