Issue 13, 2008
From the journal:

Organic & Biomolecular Chemistry

The nature of the sensitiser substituent determines quenching sensitivity and protein affinity and influences the design of emissive lanthanide complexes as optical probes for intracellular use†

Filip Kielar,a   Ga-Lai Law,a   Elizabeth J. Newa  and  David Parker*a  

* Corresponding authors

a Department of Chemistry, Durham University, South Road, Durham, UK
E-mail: david.parker@dur.ac.uk

Abstract

Introduction of different substituents at the 7-position of a sensitising azaxanthone group in a series of emissive Eu and Tb complexes can determine the intracellular uptake and distribution profile and may be linked to modulation of protein affinity.

Graphical abstract: The nature of the sensitiser substituent determines quenching sensitivity and protein affinity and influences the design of emissive lanthanide complexes as optical probes for intracellular use

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Article information

DOI
https://doi.org/10.1039/B804369H
Article type
Communication
Submitted
13 Mar 2008
Accepted
07 May 2008
First published
16 May 2008

Org. Biomol. Chem., 2008,6, 2256-2258

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The nature of the sensitiser substituent determines quenching sensitivity and protein affinity and influences the design of emissive lanthanide complexes as optical probes for intracellular use

F. Kielar, G. Law, E. J. New and D. Parker, Org. Biomol. Chem., 2008, 6, 2256 DOI: 10.1039/B804369H

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