Issue 21, 2008

Pseudouridines in rRNA helix 69 play a role in loop stacking interactions

Abstract

The 1H NMR spectra of RNAs representing E. coli23S rRNA helix 69 with [1,3-15N]pseudouridine modification at specific sites reveal unique roles for pseudouridine in stabilizing base-stacking interactions in the hairpin loop region.

Graphical abstract: Pseudouridines in rRNA helix 69 play a role in loop stacking interactions

Supplementary files

Article information

Article type
Communication
Submitted
24 Jul 2008
Accepted
01 Sep 2008
First published
19 Sep 2008

Org. Biomol. Chem., 2008,6, 3892-3895

Pseudouridines in rRNA helix 69 play a role in loop stacking interactions

J. Desaulniers, Y. Chang, R. Aduri, S. C. Abeysirigunawardena, J. SantaLucia, Jr. and C. S. Chow, Org. Biomol. Chem., 2008, 6, 3892 DOI: 10.1039/B812731J

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