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Org. Biomol. Chem., 2009, 7, 2506 - 2508, DOI: 10.1039/b903609a

The effect of microwave irradiation on DNA hybridization

Wesleigh F. Edwards, Douglas D. Young and Alexander Deiters

The effect of microwave irradiation on DNA/DNA hybridization has been studied under controlled power and temperature conditions. It was discovered that microwave irradiation led to the melting of double-stranded deoxyoligonucleotides well below their thermal melting temperature and independent of the length of the deoxyoligonucleotides. These observations indicate a specific interaction of microwaves with DNA, and have important implications in the chemical or enzymatic processing of DNA under microwave heating.

Graphical abstract image for this article (ID: b903609a)