Issue 12, 2009
From the journal:

Organic & Biomolecular Chemistry

The effect of microwave irradiation on DNA hybridization†

Wesleigh F. Edwards,a   Douglas D. Younga  and  Alexander Deiters*a  

* Corresponding authors

a Department of Chemistry, North Carolina State University, Raleigh, NC, USA
E-mail: alex_deiters@ncsu.edu
Fax: +1-919-515-5079
Tel: +1-919-513-2958

Abstract

The effect of microwave irradiation on DNA/DNA hybridization has been studied under controlled power and temperature conditions. It was discovered that microwave irradiation led to the melting of double-stranded deoxyoligonucleotides well below their thermal melting temperature and independent of the length of the deoxyoligonucleotides. These observations indicate a specific interaction of microwaves with DNA, and have important implications in the chemical or enzymatic processing of DNA under microwave heating.

Graphical abstract: The effect of microwave irradiation on DNA hybridization

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Article information

DOI
https://doi.org/10.1039/B903609A
Article type
Communication
Submitted
20 Feb 2009
Accepted
17 Apr 2009
First published
01 May 2009

Org. Biomol. Chem., 2009,7, 2506-2508

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The effect of microwave irradiation on DNA hybridization

W. F. Edwards, D. D. Young and A. Deiters, Org. Biomol. Chem., 2009, 7, 2506 DOI: 10.1039/B903609A

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