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Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.




Paper

Org. Biomol. Chem., 2010, 8, 267 - 273, DOI: 10.1039/b917428a


Facile P,N-heterocycle synthesis via tandem aminomethylation–cyclization of H-phosphinate building blocks

Clémence Queffélec and Jean-Luc Montchamp


Various heterocycles containing phosphorus and nitrogen are easily synthesized from readily available H-phosphinate building blocks. Aminomethylation of these H-phosphinates is followed by in situ cyclization through substitution or cross-coupling to produce novel heterocycles in moderate to good yields.

Graphical abstract image for this article  (ID: b917428a)