RSC Publishing


Publishing

 

Cover image for Organic & Biomolecular Chemistry, select for current issue

Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.



Subscribers

Non-subscribers

Free access



Communication

Org. Biomol. Chem., 2010, 8, 321 - 325, DOI: 10.1039/b920152a

Rapid two-step synthesis of drug-like polycyclic substances by sequential multi-catalysis cascade reactions

Dhevalapally B. Ramachary, Rumpa Mondal and Chintalapudi Venkaiah

An efficient amino acid-/self-/base-/ruthenium-/thermal-catalyzed two-step process for the synthesis of functionalized drug-like carbocycles was achieved through combinations of cascade TCRA/C-allylation/enyne-RCM/Diels–Alder reactions as key steps starting from simple acyclic substrates. In this communication, we report the two-step synthesis of drug-like carbocycles through a combination of organocatalysis with ruthenium-catalysis.

Graphical abstract image for this article (ID: b920152a)