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Communication
Article citation: Dhevalapally B. Ramachary, Org. Biomol. Chem., 2010, DOI: 10.1039/b920152a
Rapid two-step synthesis of drug-like polycyclic substances by sequential multi-catalysis cascade reactions
Dhevalapally B. Ramachary, Rumpa Mondal and Chintalapudi Venkaiah
An efficient amino acid-/self-/base-/ruthenium-/thermal-catalyzed two-step process for the synthesis of functionalized drug-like carbocycles was achieved through combinations of cascade TCRA/C-allylation/enyne-RCM/Diels–Alder reactions as key steps starting from simple acyclic substrates. In this communication, we report the two-step synthesis of drug-like carbocycles through a combination of organocatalysis with ruthenium-catalysis.
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