Issue 7, 2010
From the journal:

Organic & Biomolecular Chemistry

The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors†

Catherine F. Carter,a   Ian R. Baxendale,a   John B. J. Paveyb  and  Steven V. Ley*a  

* Corresponding authors

a Department of Chemistry, Innovative Technnology Centre, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: svl1000@cam.ac.uk

b AstraZeneca, Bakewell Road, Loughborough, Leics

Abstract

The continuous flow synthesis of butane-2,3-diacetal protected derivatives has been achieved using commercially available flow chemistry microreactors in concert with solid supported reagents and scavengers to provide in-line purification systems. The BDA protected products are all obtained in superior yield to the corresponding batch processes.

Graphical abstract: The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors

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Article information

DOI
https://doi.org/10.1039/B924309G
Article type
Paper
Submitted
19 Nov 2009
Accepted
24 Dec 2009
First published
10 Feb 2010

Org. Biomol. Chem., 2010,8, 1588-1595

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The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors

C. F. Carter, I. R. Baxendale, J. B. J. Pavey and S. V. Ley, Org. Biomol. Chem., 2010, 8, 1588 DOI: 10.1039/B924309G

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