Issue 8, 2010
From the journal:

Organic & Biomolecular Chemistry

The application of flow microreactors to the preparation of a family of casein kinase I inhibitors†‡

Francesco Venturoni,a   Nikzad Nikbin,a   Steven V. Leya  and  Ian R. Baxendalea  

a Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: TheITC@ch.cam.ac.uk

Abstract

In this article we demonstrate how a combination of enabling technologies such as flow synthesis, solid-supported reagents and scavenging resins utilised under fully automated software control can assist in typical medicinal chemistry programmes. In particular automated continuous flow methods have greatly assisted in the optimisation of reaction conditions and facilitated scale up operations involving hazardous chemical materials. Overall a collection of twenty diverse analogues of a casein kinase I inhibitor has been synthesised by changing three principle binding vectors.

Graphical abstract: The application of flow microreactors to the preparation of a family of casein kinase I inhibitors

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Article information

DOI
https://doi.org/10.1039/B925327K
Article type
Paper
Submitted
02 Dec 2009
Accepted
18 Jan 2010
First published
17 Feb 2010

Org. Biomol. Chem., 2010,8, 1798-1806

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The application of flow microreactors to the preparation of a family of casein kinase I inhibitors

F. Venturoni, N. Nikbin, S. V. Ley and I. R. Baxendale, Org. Biomol. Chem., 2010, 8, 1798 DOI: 10.1039/B925327K

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