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Soft Matter

Where physics meets chemistry meets biology for fundamental soft matter research.



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Soft Matter, 2008, 4, 2160 - 2163, DOI: 10.1039/b810885d

Tumor microvasculature targeting with dendrimer-entrapped gold nanoparticles

Rameshwer Shukla, Elliott Hill, Xiangyang Shi, Jinkoo Kim, Maria C. Muniz, Kai Sun and James R. Baker  Jr. 

Monodisperse dendrimer-entrapped gold nanoparticles (diameter = 3.0 nm) were prepared using G5 poly(amidoamine) (PAMAM) dendrimer functionalized with fluorescein isothiocyanate (FI) and Arg-Gly-Asp (RGD) peptide as template; in vitro targeting efficacy to integrin receptor expressing cells was confirmed by flow cytometry, confocal microscopy, and ICP-MS.

Graphical abstract image for this article (ID: b810885d)