Issue 14, 1995

Titanium(IV) mediated reductive aminations of 1-adamantyl methyl ketone: facile preparation of potential antiviral agents rimantadine and its analogues

Abstract

A preparatively efficient, mild method for the synthesis of rimantadine and its analogues via novel reductive aminations of 1-adamantyl methyl ketone using titanium(IV) isopropoxide and sodium borohydride is reported.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1995, 1845-1847

Titanium(IV) mediated reductive aminations of 1-adamantyl methyl ketone: facile preparation of potential antiviral agents rimantadine and its analogues

S. Bhattacharyya, J. Chem. Soc., Perkin Trans. 1, 1995, 1845 DOI: 10.1039/P19950001845

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