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Miniaturisation for chemistry, physics, biology and bioengineering
Cover Gallery
A compact and cost-effective lensless digital microscope installed on a regular cellphone is illustrated.
DOI: 10.1039/C003477K
A plate floating on a droplet is rotated at 720 rpm by changing the droplet shape continuously by electrowetting.
DOI: 10.1039/C0LC90021D
Enhancement of the analytical sensitivity and chromatographic resolution of n-alkane gas compound mixtures using a two-stage on-chip thermal modulator for comprehensive two-dimensional micro gas chromatography.
DOI: 10.1039/C001390K
Lab on a mobile display: an extremely low light intensity is sufficient to actuate droplets on single-sided continuous optoelectrowetting (SCOEW) devices.
DOI: 10.1039/C0LC90014A
Neuronal development can be engineered by surface-bound gradients of biochemical cues, signals that can be deposited with the use of microfluidic devices.
DOI: 10.1039/C001552K
A digital microfluidic platform for complete mammalian cell culture in 150-nL droplets.
DOI: 10.1039/c0lc90010a
A method using arrays of microwells permits quantification of the frequencies and rates of secretion of up to four cytokines from 10,000-100,000 live cells.
DOI: 10.1039/B926849A
Fat cells and bone-forming cells developed from mesenchymal stem cells after 3 weeks on-chip. Substrate modifications prevented cells from settling in transverse channels and thus limit medium perfusion.
DOI: 10.1039/C0LC90006K
Chip electrophoresis mass spectrometry in record speed: the cover shows a schematic drawing as well as a modified microscopic image of microfluidic glass chip, spraying in front of an MS-orifice.
DOI: 10.1039/C000349B
Reducing surface tension diminishes the effect of electrolysis bubbles, dramatically improving analyte stream stability in Micro Free Flow Electrophoresis (mFFE).
DOI: 10.1039/c0lc90002h
A microfluidic-based method for studying the response of thousands of dissociated olfactory sensory neurons to a sequence of odorants, allowing for probing all the olfactory receptor space simultaneously.
DOI: 10.1039/B920585C
Biological nanofactories are assembled via synthetic biology and biofabrication to capture and stimulate a quorum sensing response in spatially defined locales.
DOI: 10.1039/C004774K
A review is given of the important forces and phenomena in nanofluidics, and their application for the analysis of biomolecules in nanofabricated devices.
DOI: 10.1039/B917759K
Flexible post force sensor used for direct measurement of platelet forces during the clot retraction of a microthrombus.
DOI: 10.1039/C004396F
Time lapse experimental photos, and envisioned programmable lab-on-a-chip.
DOI: 10.1039/B925278A
A filtration app for enriching circulating tumor cells. A co-current filtration chip with improved hydrodynamic design reduced cellular stress.
DOI: 10.1039/C003801F
The fabricated 3-D microstructure is an output of dynamic mode multidirectional UV lithography. The unit structure shows the flower-like (lotus) shape and the tip of each leaf is connected with each other forming a hand-inhand coalition.
DOI: 10.1039/C002965N
A digital microfluidic Automaton, based on 2-dimensional microvalve array technology, enables the execution of diverse microfluidic programs for the rapid automation of bioassays.
DOI: 10.1039/c003313h
Based on particle tracking and subsequent curve fitting to the observed paths, we measure in situ the local ultrasound pressure amplitude in microfluidic chips designed for acoustophoresis of particle suspensions.
DOI: 10.1039/b920376a
An array of microfluidic chambers with bridge-and-underpass architecture, enabling continuous perfusion without cross-chamber contamination for cell culture and assay.
DOI: 10.1039/c002327m
Contactless dielectrophoresis (cDEP): an elegant and simple methodology for cell/microparticle isolation and enrichment. Two microfluidic devices demonstrate the potential of cDEP technology through the separation of ive/dead THP-1 human cells.
DOI: 10.1039/b920590j
A pumpless body-on-a-chip system with 3-D hydrogel cell cultures is combined with a mathematical model to provide a human surrogate for drugtoxicity testing.
DOI: 10.1039/c001269f
Massively parallel inertial focusing of blood cells allows for sheathless flow cytometry at 1 million cells/s.
DOI: 10.1039/b919495a
Cartridge for multiplex label-free biosensing with an optical slot-waveguide ring resonator array and integrated microfluidic sample handling..
DOI: 10.1039/c000211a
Microfluidic systems that mimic the blood vessel microenvironment can provide new insights into endothelial cell biology.
DOI: 10.1039/b913390a
Practical cell control made easy; a new tool for home projectorbased optical manipulation for cells in their native environment. The background shows cell array,separation, collection and interaction functions.
DOI: 10.1039/b925938b
A simple ''kidney-on-a-chip'' in the form of a multi-layer microfluidic device by combining fluidic shear stress and porous membrane support to efficiently culture and analyze renal tubular cells.
DOI: 10.1039/b907515a
Electrochemical detection was incorporated in a microchip for recording quantal exocytosis events. Cells automatically depolarized upon entering the electric field gradient in the microchamber enabling flow-through amperometry.
DOI: 10.1039/b924731a
