RSC - Mol. BioSyst. latest articles http://xlink.rsc.org/jumptojournal.cfm?journal_code=MB The Royal Society of Chemistry en-gb Copyright (c) 2010 The Royal Society of Chemistry Mol. BioSyst. Copyright (c) The Royal Society of Chemistry contracts-copyright@rsc.org 1742-206X1742-2051The Royal Society of Chemistry The Royal Society of Chemistry Royal Society of Chemistry - Mol. BioSyst. latest articles RSC - Mol. BioSyst. latest articles http://www.rsc.org text/html text http://xlink.rsc.org/?DOI=b916137f&RSS=1 Here, we review recent advances in DNA-centered approaches aiming to capture protein complexes on defined regulatory loci and to correlate changes in their composition with alterations in target gene expression.<p><img align="center" src="http://www.rsc.org/ejga/MB/2010/b916137f-ga.gif"/> </p>Jovan Simicevic, Bart Deplancke <br/> (Review from Mol. BioSyst.)<br/> Jovan Simicevic, Mol. BioSyst., 2010, DOI: 10.1039/b916137f<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry DNA-centered approaches to characterize regulatory protein-DNA interaction complexes Jovan Simicevic Bart Deplancke 10.1039/b916137f Mol. BioSyst., 2010, DOI: 10.1039/b916137f html/pdf 2009-12-02 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b916137f http://xlink.rsc.org/?DOI=b906951h&RSS=1 We present a stochastic kinetic model of the two component signalling system. It is an evolvable signal transduction mechanism capable of implementing all-or-none, graded and mixed mode stochastic switching responses.<p><img align="center" src="http://www.rsc.org/ejga/MB/2010/b906951h-ga.gif"/> </p>Andrzej M. Kierzek, Lu Zhou, Barry L. Wanner <br/> (Paper from Mol. BioSyst.)<br/> Andrzej M. Kierzek, Mol. BioSyst., 2010, DOI: 10.1039/b906951h<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Stochastic kinetic model of two component system signalling reveals all-or-none, graded and mixed mode stochastic switching responses Andrzej M. Kierzek Lu Zhou Barry L. Wanner 10.1039/b906951h Mol. BioSyst., 2010, DOI: 10.1039/b906951h html/pdf 2009-12-02 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b906951h http://xlink.rsc.org/?DOI=b918106g&RSS=1 Isolation and structural elucidation of TLM H-1 and H-2 from the [capital Delta]tlmH mutant supports the functional assignment of TLMH to catalyze hydroxylation at both C-41 and C-42 for TLM biosynthesis.<p><img align="center" src="http://www.rsc.org/ejga/MB/2010/b918106g-ga.gif"/> </p>Meifeng Tao, Liyan Wang, Evelyn Wendt-Pienkowski, Ningning Zhang, Dong Yang, Ute Galm, Jane M. Coughlin, Zhinan Xu, Ben Shen <br/> (Paper from Mol. BioSyst.)<br/> Meifeng Tao, Mol. BioSyst., 2010, DOI: 10.1039/b918106g<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Functional characterization of tlmH in Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insight into tallysomycin biosynthesis and affording a novel bleomycin analog Meifeng Tao Liyan Wang Evelyn Wendt-Pienkowski Ningning Zhang Dong Yang Ute Galm Jane M. Coughlin Zhinan Xu Ben Shen 10.1039/b918106g Mol. BioSyst., 2010, DOI: 10.1039/b918106g html/pdf 2009-12-01 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b918106g http://xlink.rsc.org/?DOI=b912336a&RSS=1 This paper describes a new series of 4[small beta]-anilino-podophyllotoxin analogs as topoisomerase II and P-gp-dependent multidrug resistance (MDR) inhibitors. Compound 5n showed a promising potency as a potential drug candidate for anticancer chemotherapy.<p><img align="center" src="http://www.rsc.org/ejga/MB/2010/b912336a-ga.gif"/> </p>Chunqi Hu, Danqing Xu, Wenting Du, Shijing Qian, Li Wang, Jianshu Lou, Qiaojun He, Bo Yang, Yongzhou Hu <br/> (Paper from Mol. BioSyst.)<br/> Chunqi Hu, Mol. BioSyst., 2010, DOI: 10.1039/b912336a<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Novel 4[small beta]-anilino-podophyllotoxin derivatives: design synthesis and biological evaluation as potent DNA-topoisomerase II poisons and anti-MDR agents Chunqi Hu Danqing Xu Wenting Du Shijing Qian Li Wang Jianshu Lou Qiaojun He Bo Yang Yongzhou Hu 10.1039/b912336a Mol. BioSyst., 2010, DOI: 10.1039/b912336a html/pdf 2009-12-01 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b912336a http://xlink.rsc.org/?DOI=b914428e&RSS=1 The detailed uptake mechanism of microspheres into a range of cell lines was studied. Gene expression profiles of "beadfected" and untreated cells were used to establish the effect of microsphere uptake at the transcriptional level.<p><img align="center" src="http://www.rsc.org/ejga/MB/2010/b914428e-ga.gif"/> </p>Lois M. Alexander, Salvatore Pernagallo, Alessandra Livigni, Rosario M. Sanchez-Martin, Joshua M. Brickman, Mark Bradley <br/> (Paper from Mol. BioSyst.)<br/> Lois M. Alexander, Mol. BioSyst., 2010, DOI: 10.1039/b914428e<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Investigation of microsphere-mediated cellular delivery by chemical, microscopic and gene expression analysis Lois M. Alexander Salvatore Pernagallo Alessandra Livigni Rosario M. Sanchez-Martin Joshua M. Brickman Mark Bradley 10.1039/b914428e Mol. BioSyst., 2010, DOI: 10.1039/b914428e html/pdf 2009-11-26 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b914428e http://xlink.rsc.org/?DOI=b903019k&RSS=1 Side-chain interactions in protein structure networks show random behavior and deviations from this random model have significant biological implications.<p><img align="center" src="http://www.rsc.org/ejga/MB/2010/b903019k-ga.gif"/> </p>K. V. Brinda, Saraswathi Vishveshwara, Smitha Vishveshwara <br/> (Paper from Mol. BioSyst.)<br/> K. V. Brinda, Mol. BioSyst., 2010, DOI: 10.1039/b903019k<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/><a href='http://obofoundry.org/' target="'_BLANK'">Ontology Terms:</a> transcription factor activity; adenylate kinase activity; carboxypeptidase activity; lactate dehydrogenase activity; phosphoglycerate kinase activity; triose-phosphate isomerase activity; glutamine-tRNA ligase activity; protein folding; peptidase activity; phosphofructokinase activity; glyceraldehyde-3-phosphate dehydrogenase activity; endo-1,4-beta-xylanase activity; signal recognition particle; heteropolymer molecule; TATA_box; amino-acid residue; protein; L-tyrosine residue; Gln-tRNA(Gln); disulfanediyl group; peptide; L-phenylalanine residue; transfer RNA; protein polypeptide chain; L-arabinose <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Random network behaviour of protein structures K. V. Brinda Saraswathi Vishveshwara Smitha Vishveshwara 10.1039/b903019k Mol. BioSyst., 2010, DOI: 10.1039/b903019k html/pdf 2009-11-16 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b903019k http://xlink.rsc.org/?DOI=b916104j&RSS=1 PUPylation is a prokaryotic post-translation modification that, similar to ubiquitin, has been previously implicated in proteasomal degradation. By performing a global proteomic pull-down from Mycobacterium smegmatis 155 protein targets for PUPylation were identifed.<p><img align="center" src="http://www.rsc.org/ejga/MB/2010/b916104j-ga.gif"/> </p>Jeramie Watrous, Kristin Burns, Wei-Ting Liu, Anand Patel, Vivian Hook, Vineet Bafna, Clifton E. Barry 3rd, Steve Bark, Pieter C. Dorrestein <br/> (Paper from Mol. BioSyst.)<br/> Jeramie Watrous, Mol. BioSyst., 2010, DOI: 10.1039/b916104j<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Expansion of the mycobacterial "PUPylome" Jeramie Watrous Kristin Burns Wei-Ting Liu Anand Patel Vivian Hook Vineet Bafna Clifton E. Barry 3rd Steve Bark Pieter C. Dorrestein 10.1039/b916104j Mol. BioSyst., 2010, DOI: 10.1039/b916104j html/pdf 2009-11-16 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b916104j http://xlink.rsc.org/?DOI=b910552m&RSS=1 Hyaluronan is an extracellular component whose expression is perturbed in disease. Manipulation of hyaluronan by nanotechnology may be of therapeutic benefit.<p><img align="center" src="http://www.rsc.org/ejga/MB/2010/b910552m-ga.gif"/> </p>John Gaffney, Sabine Matou-Nasri, Marta Grau-Olivares, Mark Slevin <br/> (Review from Mol. BioSyst.)<br/> John Gaffney, Mol. BioSyst., 2010, DOI: 10.1039/b910552m<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/><a href='http://obofoundry.org/' target="'_BLANK'">Ontology Terms:</a> cell death; amino-acid residue; protein; macromolecule; sperm; fibroblast; epithelial cell; endothelial cell; glial cell; astrocyte; microglial cell; chondrocyte; beta-glucuronidase activity; macrophage; neuron; endothelial cell proliferation; RNA-directed DNA polymerase activity; hyalurononglucosaminidase activity; epidermal growth factor receptor binding; MAP kinase 1 activity; cell motility; dicarba-closo-dodecaborane(12); amino acid; hydrazide; disaccharide; tyramines; polysaccharide; chondroitin sulfate; hydroxy group; indicator; Schiff base; sugar; glycoprotein; gene expression; gold nanoparticle; nanoparticle; silver nanoparticle; confocal microscopy; glycosylation; optical micrograph; activation; inorganic nanoparticle; angiogenesis; stress fiber; peroxidase activity; death receptor activity; receptor binding; extracellular region; chromosome; mitochondrion; lysosome; cytoskeleton; plasma membrane; endocytosis; apoptosis; inflammatory response; immune response; leukocyte adhesion; signal transduction; metabolic process; cell proliferation; biosynthetic process; post-embryonic development; cell surface; death; kinase activity; phosphorylation; hyaluronate lyase activity; extracellular matrix; immunoglobulin complex, circulating; neuron projection; cell soma; hyaluronan synthase activity; water binding; cell division; exon; pseudogene; siRNA; gene; tandem_repeat; post-translational protein modification; glucuronic acids; drug; messenger RNA; glycosaminoglycan; proteoglycan; glucose; hyaluronic acid; carboxy group; poly(ethylene glycol); alternate_sequence_site; tetrasaccharide <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Therapeutic applications of hyaluronan John Gaffney Sabine Matou-Nasri Marta Grau-Olivares Mark Slevin 10.1039/b910552m Mol. BioSyst., 2010, DOI: 10.1039/b910552m html/pdf 2009-11-12 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b910552m http://xlink.rsc.org/?DOI=b916175a&RSS=1 This review will describe the importance of angiogenesis in mediation of atherosclerotic plaque growth and superparamagnetic/perfluorocarbon-derived nanoparticles for imaging of the vasculature in this disease.<p><img align="center" src="http://www.rsc.org/ejga/MB/2010/b916175a-ga.gif"/> </p>M. Slevin, L. Badimon, M. Grau-Olivares, M. Ramis, J. Sendra, M. Morrison, J. Krupinski <br/> (Review from Mol. BioSyst.)<br/> M. Slevin, Mol. BioSyst., 2010, DOI: 10.1039/b916175a<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Combining nanotechnology with current biomedical knowledge for the vascular imaging and treatment of atherosclerosis M. Slevin L. Badimon M. Grau-Olivares M. Ramis J. Sendra M. Morrison J. Krupinski 10.1039/b916175a Mol. BioSyst., 2010, DOI: 10.1039/b916175a html/pdf 2009-11-12 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b916175a http://xlink.rsc.org/?DOI=b921381n&RSS=1 M. Madan Babu and Hirotada Mori introduce this themed issue of Molecular BioSystems focusing on Computational and systems biology<p><img align="center" src="http://www.rsc.org/ejga/MB/2009/b921381n-ga.gif"/> </p> (Editorial from Mol. BioSyst.)<br/> Mol. BioSyst., 2009, 5, 1391 <br/>DOI: 10.1039/b921381n <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Computational and Systems Biology RSC 10.1039/b921381n Mol. BioSyst., 2009, 5, 1391 DOI: 10.1039/b921381n html/pdf 2009-11-06 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b921381n 5121391