RSC - Org. Biomol. Chem. latest articles http://xlink.rsc.org/jumptojournal.cfm?journal_code=OB The Royal Society of Chemistry en-gb Copyright (c) 2010 The Royal Society of Chemistry Org. Biomol. Chem. Copyright (c) The Royal Society of Chemistry contracts-copyright@rsc.org 1477-05201477-0539The Royal Society of Chemistry The Royal Society of Chemistry Royal Society of Chemistry - Org. Biomol. Chem. latest articles RSC - Org. Biomol. Chem. latest articles http://www.rsc.org text/html text http://xlink.rsc.org/?DOI=b915864b&RSS=1 The self-assembly as well as the dissociation of two dynamic [2]rotaxanes have been demonstrated. Somewhat surprisingly, the [2]rotaxanes show remarkable relative stabilities in the presence of large amounts of water. In particular, the dissociation rates of the rotaxanes toward hydrolysis have been determined.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b915864b-ga.gif"/> </p>Ken Cham-Fai Leung, Wing-Yan Wong, Fabio Arico, Philip C. Haussmann, J. Fraser Stoddart <br/> (Paper from Org. Biomol. Chem.)<br/> Ken Cham-Fai Leung, Org. Biomol. Chem., 2010, DOI: 10.1039/b915864b<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry The stability of imine-containing dynamic [2]rotaxanes to hydrolysis Ken Cham-Fai Leung Wing-Yan Wong Fabio Arico Philip C. Haussmann J. Fraser Stoddart 10.1039/b915864b Org. Biomol. Chem., 2010, DOI: 10.1039/b915864b html/pdf 2009-11-20 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b915864b http://xlink.rsc.org/?DOI=b917793k&RSS=1 4-Fluoro-2(5H)-furanones and (E)-3-fluoro-4-oxo-2-alkenoates were highly selectively generated from 2,4-disubstituted 2,3-allenoates with Selectfluor[trade mark sign] in moderate to high yields under different reaction conditions. A mechanism has been proposed.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b917793k-ga.gif"/> </p>Bo Lu, Chunling Fu, Shengming Ma <br/> (Paper from Org. Biomol. Chem.)<br/> Bo Lu, Org. Biomol. Chem., 2010, DOI: 10.1039/b917793k<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Study on the selectivity in the electrophilic monofluorination of 2,3-allenoates with Selectfluor[trade mark sign]: an efficient synthesis of 4-fluoro-2(5H)-furanones and 3-fluoro-4-oxo-2(E)-alkenoates Bo Lu Chunling Fu Shengming Ma 10.1039/b917793k Org. Biomol. Chem., 2010, DOI: 10.1039/b917793k html/pdf 2009-11-19 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b917793k http://xlink.rsc.org/?DOI=b912042d&RSS=1 Hydrolysis of a trinucleoside monophosphate model with a 2[prime or minute]-trifluoroacetamido-modified 3[prime or minute]-leaving group has been followed by HPLC over a wide pH range to study the effects of potential hydrogen bonding interactions of the 2[prime or minute]-trifluoroacetamido function on the rate and product distribution of the reaction.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b912042d-ga.gif"/> </p>Tuomas Lonnberg, Maarit Laine <br/> (Paper from Org. Biomol. Chem.)<br/> Tuomas Lonnberg, Org. Biomol. Chem., 2010, DOI: 10.1039/b912042d<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Phosphorane intermediate vs. leaving group stabilization by intramolecular hydrogen bonding in the cleavage of trinucleoside monophosphates: implications for understanding catalysis by the large ribozymes Tuomas Lonnberg Maarit Laine 10.1039/b912042d Org. Biomol. Chem., 2010, DOI: 10.1039/b912042d html/pdf 2009-11-19 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b912042d http://xlink.rsc.org/?DOI=b919365k&RSS=1 A thorough comparative study to demonstrate the properties of a new microwave labile backbone amide linker is presented.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b919365k-ga.gif"/> </p>Stijn Claerhout, Thibault Duchene, Dirk Tourwe, Erik V. Van der Eycken <br/> (Communication from Org. Biomol. Chem.)<br/> Stijn Claerhout, Org. Biomol. Chem., 2010, DOI: 10.1039/b919365k<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Development of a new microwave-assisted cleavable backbone amide linker (BAL): a comparative study Stijn Claerhout Thibault Duchene Dirk Tourwe Erik V. Van der Eycken 10.1039/b919365k Org. Biomol. Chem., 2010, DOI: 10.1039/b919365k html/pdf 2009-11-19 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b919365k http://xlink.rsc.org/?DOI=b916419g&RSS=1 A general method for the synthesis of [11C-carbonyl]-radiolabelled carbamates from cyclotron-produced [11C]-CO2 and primary or secondary amines is described. Using this method the selective kappa opioid agonist, [11C-carbonyl]-GR103545, was prepared in high yield and at high specific activity, suitable for human positron emission tomography studies.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b916419g-ga.gif"/> </p>Alan A. Wilson, Armando Garcia, Sylvain Houle, Neil Vasdev <br/> (Paper from Org. Biomol. Chem.)<br/> Alan A. Wilson, Org. Biomol. Chem., 2010, DOI: 10.1039/b916419g<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Direct fixation of [11C]-CO2 by amines: formation of [11C-carbonyl]-methylcarbamates Alan A. Wilson Armando Garcia Sylvain Houle Neil Vasdev 10.1039/b916419g Org. Biomol. Chem., 2010, DOI: 10.1039/b916419g html/pdf 2009-11-18 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b916419g http://xlink.rsc.org/?DOI=b908540h&RSS=1 A type of 1,1[prime or minute]-binaphthyl-based imidazolium chemosensor module has been synthesized for the highly selective recognition of tryptophan (Trp) in aqueous solutions via synergistic effects of multiple hydrogen bonding and electrostatic interactions.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b908540h-ga.gif"/> </p>Li Yang, Song Qin, Xiaoyu Su, Fei Yang, Jingsong You, Changwei Hu, Rugang Xie, Jingbo Lan <br/> (Paper from Org. Biomol. Chem.)<br/> Li Yang, Org. Biomol. Chem., 2010, DOI: 10.1039/b908540h<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry 1,1[prime or minute]-Binaphthyl-based imidazolium chemosensors for highly selective recognition of tryptophan in aqueous solutions Li Yang Song Qin Xiaoyu Su Fei Yang Jingsong You Changwei Hu Rugang Xie Jingbo Lan 10.1039/b908540h Org. Biomol. Chem., 2010, DOI: 10.1039/b908540h html/pdf 2009-11-17 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b908540h http://xlink.rsc.org/?DOI=b919289a&RSS=1 Room temperature photo-induced electron transfer studies of bis(terpyridine)ruthenium(ii) cytochrome c bioconjugates show that the protein is effectively reduced within 5 min in the presence of 20 mM EDTA.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b919289a-ga.gif"/> </p>Joshua R. Peterson, Trevor A. Smith, Pall Thordarson <br/> (Paper from Org. Biomol. Chem.)<br/> Joshua R. Peterson, Org. Biomol. Chem., 2010, DOI: 10.1039/b919289a<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Synthesis and room temperature photo-induced electron transfer in biologically active bis(terpyridine)ruthenium(ii)-cytochrome c bioconjugates and the effect of solvents on the bioconjugation of cytochrome c Joshua R. Peterson Trevor A. Smith Pall Thordarson 10.1039/b919289a Org. Biomol. Chem., 2010, DOI: 10.1039/b919289a html/pdf 2009-11-16 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b919289a http://xlink.rsc.org/?DOI=b916580k&RSS=1 A panel of disaccharide analogs have been synthesized and used to probe a mannosyltransferase involved in lipoarabinomannan biosynthesis in mycobacteria, including the human pathogen Mycobacterium tuberculosis.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b916580k-ga.gif"/> </p>Pui Hang Tam, Todd L. Lowary <br/> (Paper from Org. Biomol. Chem.)<br/> Pui Hang Tam, Org. Biomol. Chem., 2010, DOI: 10.1039/b916580k<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Epimeric and amino disaccharide analogs as probes of an [small alpha]-(1[rightward arrow]6)-mannosyltransferase involved in mycobacterial lipoarabinomannan biosynthesis Pui Hang Tam Todd L. Lowary 10.1039/b916580k Org. Biomol. Chem., 2010, DOI: 10.1039/b916580k html/pdf 2009-11-16 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b916580k http://xlink.rsc.org/?DOI=b919546g&RSS=1 Strategic incorporation of sulfonic acid, carboxylic acid or ammonium salt motifs generate water soluble BF2-chelated tetraarylazadipyrromethenes which exhibit strong near infra-red (NIR) emissions above 720 nm and can be readily imaged in both eukaryotic and prokaryotic cells.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b919546g-ga.gif"/> </p>Mariusz Tasior, Julie Murtagh, Daniel O. Frimannsson, Shane O. McDonnell, Donal F. O'Shea <br/> (Communication from Org. Biomol. Chem.)<br/> Mariusz Tasior, Org. Biomol. Chem., 2010, DOI: 10.1039/b919546g<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Water-solubilised BF2-chelated tetraarylazadipyrromethenes Mariusz Tasior Julie Murtagh Daniel O. Frimannsson Shane O. McDonnell Donal F. O'Shea 10.1039/b919546g Org. Biomol. Chem., 2010, DOI: 10.1039/b919546g html/pdf 2009-11-16 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b919546g http://xlink.rsc.org/?DOI=b917923b&RSS=1 Impregnated copper on magnetite is an efficient and green catalyst for the multicomponent acetylene-Mannich reaction.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b917923b-ga.gif"/> </p>Maria J. Aliaga, Diego J. Ramon, Miguel Yus <br/> (Communication from Org. Biomol. Chem.)<br/> Maria J. Aliaga, Org. Biomol. Chem., 2010, DOI: 10.1039/b917923b<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Impregnated copper on magnetite: an efficient and green catalyst for the multicomponent preparation of propargylamines under solvent free conditions Maria J. Aliaga Diego J. Ramon Miguel Yus 10.1039/b917923b Org. Biomol. Chem., 2010, DOI: 10.1039/b917923b html/pdf 2009-11-16 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b917923b http://xlink.rsc.org/?DOI=b914193f&RSS=1 LeA-LacNAc was found to be a ligand for toxin A released by Clostridium difficile. Here we report the efficient synthesis of the pentasaccharide for use to characterize the carbohydrate-binding site of the toxin by X-ray crystallography.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b914193f-ga.gif"/> </p>Ping Zhang, Kenneth Ng, Chang-Chun Ling <br/> (Paper from Org. Biomol. Chem.)<br/> Ping Zhang, Org. Biomol. Chem., 2010, DOI: 10.1039/b914193f<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Total synthesis of LeA-LacNAc pentasaccharide as a ligand for Clostridium difficile toxin A Ping Zhang Kenneth Ng Chang-Chun Ling 10.1039/b914193f Org. Biomol. Chem., 2010, DOI: 10.1039/b914193f html/pdf 2009-11-13 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b914193f http://xlink.rsc.org/?DOI=b909133e&RSS=1 The volatile tropone, its derivatives, and several thioesters are produced by Phaeobacter gallaeciensis, a bacterium of the Roseobacter clade that dominates many marine bacterial communities.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b909133e-ga.gif"/> </p>Verena Thiel, Thorsten Brinkhoff, Jeroen S. Dickschat, Susanne Wickel, Jorg Grunenberg, Irene Wagner-Dobler, Meinhard Simon, Stefan Schulz <br/> (Paper from Org. Biomol. Chem.)<br/> Verena Thiel, Org. Biomol. Chem., 2010, DOI: 10.1039/b909133e<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Identification and biosynthesis of tropone derivatives and sulfur volatiles produced by bacteria of the marine Roseobacter clade Verena Thiel Thorsten Brinkhoff Jeroen S. Dickschat Susanne Wickel Jorg Grunenberg Irene Wagner-Dobler Meinhard Simon Stefan Schulz 10.1039/b909133e Org. Biomol. Chem., 2010, DOI: 10.1039/b909133e html/pdf 2009-11-12 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b909133e http://xlink.rsc.org/?DOI=b915180j&RSS=1 The bioactive conformation of flexible [small kappa] agonists was approached by the design, synthesis and pharmacological evaluation of conformationally constrained 1,4-diazabicyclo[3.3.1]nonanes. It was shown that endo-orientation of the amino group is crucial for high [small kappa] receptor affinity.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b915180j-ga.gif"/> </p>Daniel Kracht, Elisabeth Rack, Dirk Schepmann, Roland Frohlich, Bernhard Wunsch <br/> (Paper from Org. Biomol. Chem.)<br/> Daniel Kracht, Org. Biomol. Chem., 2010, DOI: 10.1039/b915180j<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Stereoselective synthesis and structure-affinity relationships of bicyclic [small kappa] receptor agonists Daniel Kracht Elisabeth Rack Dirk Schepmann Roland Frohlich Bernhard Wunsch 10.1039/b915180j Org. Biomol. Chem., 2010, DOI: 10.1039/b915180j html/pdf 2009-11-12 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b915180j http://xlink.rsc.org/?DOI=b916088d&RSS=1 The main focus of this perspective lies in the discussion of the recent mechanistic theories and supporting experimental evidences that have been put forth in an attempt to advance our understanding of the factors affecting chemical glycosylation.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b916088d-ga.gif"/> </p>Laurel K. Mydock, Alexei V. Demchenko <br/> (Perspective from Org. Biomol. Chem.)<br/> Laurel K. Mydock, Org. Biomol. Chem., 2010, DOI: 10.1039/b916088d<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Mechanism of chemical O-glycosylation: from early studies to recent discoveries Laurel K. Mydock Alexei V. Demchenko 10.1039/b916088d Org. Biomol. Chem., 2010, DOI: 10.1039/b916088d html/pdf 2009-11-12 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b916088d http://xlink.rsc.org/?DOI=b915450g&RSS=1 Sequential triple and quadruple debenzylations by diisobutylaluminium hydride were investigated for [small alpha]-, [small beta]- and [gamma]-cyclodextrins. A distinct regioselective debenzylation path was observed for [small alpha]-CD compared to [small beta]- and [gamma]-cyclodextrins.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b915450g-ga.gif"/> </p>Girish K. Rawal, Shikha Rani, Sandra Ward, Chang-Chun Ling <br/> (Paper from Org. Biomol. Chem.)<br/> Girish K. Rawal, Org. Biomol. Chem., 2010, DOI: 10.1039/b915450g<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry DIBAL-H mediated triple and quadruple debenzylations of perbenzylated cyclodextrins Girish K. Rawal Shikha Rani Sandra Ward Chang-Chun Ling 10.1039/b915450g Org. Biomol. Chem., 2010, DOI: 10.1039/b915450g html/pdf 2009-11-12 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b915450g http://xlink.rsc.org/?DOI=b913300n&RSS=1 There is currently much excitement surrounding the rapidly growing discipline of synthetic biology, which utilizes the design and construction principles of engineering to develop, evolve and standardize biological components and systems. Here we discuss the achievements of the field so far, and go on to outline its potential future directions.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b913300n-ga.gif"/> </p>Ali Tavassoli <br/> (Emerging Area from Org. Biomol. Chem.)<br/> Ali Tavassoli, Org. Biomol. Chem., 2010, DOI: 10.1039/b913300n<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Synthetic biology Ali Tavassoli 10.1039/b913300n Org. Biomol. Chem., 2010, DOI: 10.1039/b913300n html/pdf 2009-11-10 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b913300n http://xlink.rsc.org/?DOI=b919526b&RSS=1 A short chemoenzymatic synthesis of [small beta]-aryl-[gamma]-aminobutyric acids has been developed, based on a highly enantioselective biocatalytic reduction of [small beta]-aryl-[small beta]-cyano-[small alpha],[small beta]-unsaturated carboxylic acids.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b919526b-ga.gif"/> </p>Anna Fryszkowska, Karl Fisher, John M. Gardiner, Gill M. Stephens <br/> (Communication from Org. Biomol. Chem.)<br/> Anna Fryszkowska, Org. Biomol. Chem., 2010, DOI: 10.1039/b919526b<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry A short, chemoenzymatic route to chiral [small beta]-aryl-[gamma]-amino acids using reductases from anaerobic bacteria Anna Fryszkowska Karl Fisher John M. Gardiner Gill M. Stephens 10.1039/b919526b Org. Biomol. Chem., 2010, DOI: 10.1039/b919526b html/pdf 2009-11-10 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b919526b http://xlink.rsc.org/?DOI=b919246h&RSS=1 A new, heterogeneous, magnesium-lanthanum mixed oxide solid base-supported nickel(ii) catalyst was developed. The catalyst was successfully used in the Kumada coupling of aryl halides, especially aryl bromides. The optimal reaction conditions of the coupling were determined.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b919246h-ga.gif"/> </p>Arpad Kiss, Zoltan Hell, Maria Balint <br/> (Communication from Org. Biomol. Chem.)<br/> Arpad Kiss, Org. Biomol. Chem., 2010, DOI: 10.1039/b919246h<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Nickel/magnesium-lanthanum mixed oxide catalyst in the Kumada-coupling Arpad Kiss Zoltan Hell Maria Balint 10.1039/b919246h Org. Biomol. Chem., 2010, DOI: 10.1039/b919246h html/pdf 2009-11-10 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b919246h http://xlink.rsc.org/?DOI=b913399b&RSS=1 A versatile approach to the synthesis of the complete family of phosphatidylinositol phosphate (PIP) analogues and their use as affinity probes are described.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b913399b-ga.gif"/> </p>Stuart J. Conway, James Gardiner, Simon J. A. Grove, Melloney K. Johns, Ze-Yi Lim, Gavin F. Painter, Diane E. J. E. Robinson, Christine Schieber, Jan W. Thuring, Leon S.-M. Wong, Meng-Xin Yin, Antony W. Burgess, Bruno Catimel, Phillip T. Hawkins, Nicholas T. Ktistakis, Leonard R. Stephens, Andrew B. Holmes <br/> (Paper from Org. Biomol. Chem.)<br/> Stuart J. Conway, Org. Biomol. Chem., 2010, DOI: 10.1039/b913399b<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes Stuart J. Conway James Gardiner Simon J. A. Grove Melloney K. Johns Ze-Yi Lim Gavin F. Painter Diane E. J. E. Robinson Christine Schieber Jan W. Thuring Leon S.-M. Wong Meng-Xin Yin Antony W. Burgess Bruno Catimel Phillip T. Hawkins Nicholas T. Ktistakis Leonard R. Stephens Andrew B. Holmes 10.1039/b913399b Org. Biomol. Chem., 2010, DOI: 10.1039/b913399b html/pdf 2009-11-09 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b913399b http://xlink.rsc.org/?DOI=b919396k&RSS=1 An efficient and convenient approach to construct C-C bonds at the 2-position of azoles via Cu(OAc)2/air mediated oxidative homo- and cross-coupling reaction was reported. The corresponding products were obtained in good to excellent yield.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b919396k-ga.gif"/> </p>Yan Li, Jun Jin, Weixing Qian, Weiliang Bao <br/> (Communication from Org. Biomol. Chem.)<br/> Yan Li, Org. Biomol. Chem., 2010, DOI: 10.1039/b919396k<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry An efficient and convenient Cu(OAc)2/air mediated oxidative coupling of azoles via C-H activation Yan Li Jun Jin Weixing Qian Weiliang Bao 10.1039/b919396k Org. Biomol. Chem., 2010, DOI: 10.1039/b919396k html/pdf 2009-11-09 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b919396k http://xlink.rsc.org/?DOI=b911482c&RSS=1 Based on insights gained from a DFT study of current cyclooctyne-based labelling reagents, we propose a new class of benzocyclooctyne reagents for copper-free [3+2] azide-alkyne cycloaddition reactions that are predicted to be have a rate comparable to copper-catalyzed reactions.<p><img align="center" src="http://www.rsc.org/ejga/OB/2009/b911482c-ga.gif"/> </p>Kimberly Chenoweth, David Chenoweth, William A. Goddard III <br/> (Paper from Org. Biomol. Chem.)<br/> Kimberly Chenoweth, Org. Biomol. Chem., 2009, DOI: 10.1039/b911482c<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Cyclooctyne-based reagents for uncatalyzed click chemistry: A computational survey Kimberly Chenoweth David Chenoweth William A. Goddard III 10.1039/b911482c Org. Biomol. Chem., 2009, DOI: 10.1039/b911482c html/pdf 2009-11-09 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b911482c http://xlink.rsc.org/?DOI=b919387a&RSS=1 Triplex DNA binders can effectively control copper-catalysed alkyne-azide click reactions in DNA architecture, such that either duplex or triplex DNA directed reactions of terminally attached azides and alkynes occur, in the absence or presence of triplex DNA binder, respectively.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b919387a-ga.gif"/> </p>Mikkel F. Jacobsen, Jens B. Ravnsbaek, Kurt V. Gothelf <br/> (Communication from Org. Biomol. Chem.)<br/> Mikkel F. Jacobsen, Org. Biomol. Chem., 2010, DOI: 10.1039/b919387a<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Small molecule induced control in duplex and triplex DNA-directed chemical reactions Mikkel F. Jacobsen Jens B. Ravnsbaek Kurt V. Gothelf 10.1039/b919387a Org. Biomol. Chem., 2010, DOI: 10.1039/b919387a html/pdf 2009-11-09 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b919387a http://xlink.rsc.org/?DOI=b915694a&RSS=1 The cucurbit[7]uril host molecule binds to procaine, and other local anaesthetic drugs, 2-3 orders of magnitude stronger than [small beta]-cyclodextrin in aqueous solution, resulting in increases in the value of pK1 and enhanced fluorescence.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b915694a-ga.gif"/> </p>Ian W. Wyman, Donal H. Macartney <br/> (Paper from Org. Biomol. Chem.)<br/> Ian W. Wyman, Org. Biomol. Chem., 2010, DOI: 10.1039/b915694a<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Host-guest complexations of local anaesthetics by cucurbit[7]uril in aqueous solution Ian W. Wyman Donal H. Macartney 10.1039/b915694a Org. Biomol. Chem., 2010, DOI: 10.1039/b915694a html/pdf 2009-11-06 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b915694a http://xlink.rsc.org/?DOI=b918877k&RSS=1 Ruthenium half-sandwich Lewis-acids can efficiently catalyze 1,4-additions of aryl thiols to enones with remarkable levels of activity and selectivity, in spite of stereocontrol complexity and potential catalyst inhibition. NMR experiments provide an insight to the intricate equilibria governing the reaction mechanism.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b918877k-ga.gif"/> </p>Andrei Badoiu, Gerald Bernardinelli, Celine Besnard, E. Peter Kundig <br/> (Paper from Org. Biomol. Chem.)<br/> Andrei Badoiu, Org. Biomol. Chem., 2010, DOI: 10.1039/b918877k<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Asymmetric ruthenium-catalyzed 1,4-additions of aryl thiols to enones Andrei Badoiu Gerald Bernardinelli Celine Besnard E. Peter Kundig 10.1039/b918877k Org. Biomol. Chem., 2010, DOI: 10.1039/b918877k html/pdf 2009-11-06 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b918877k http://xlink.rsc.org/?DOI=b910545j&RSS=1 Using Sc(OTf)3 and microwaves, direct double dehydrocyclization of anthranilate-containing tripeptides was efficiently achieved, to afford total syntheses of fused quinazolinones in short reaction times, with good overall isolated yields.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b910545j-ga.gif"/> </p>Ming-Chung Tseng, Huei-Yun Yang, Yen-Ho Chu <br/> (Paper from Org. Biomol. Chem.)<br/> Ming-Chung Tseng, Org. Biomol. Chem., 2010, DOI: 10.1039/b910545j<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Total synthesis of asperlicin C, circumdatin F, demethylbenzomalvin A, demethoxycircumdatin H, sclerotigenin, and other fused quinazolinones Ming-Chung Tseng Huei-Yun Yang Yen-Ho Chu 10.1039/b910545j Org. Biomol. Chem., 2010, DOI: 10.1039/b910545j html/pdf 2009-11-05 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b910545j http://xlink.rsc.org/?DOI=b917428a&RSS=1 Various heterocycles containing phosphorus and nitrogen are easily synthesized from readily available H-phosphinate building blocks via aminomethylation and in situ cyclization through substitution or cross-coupling.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b917428a-ga.gif"/> </p>Clemence Queffelec, Jean-Luc Montchamp <br/> (Paper from Org. Biomol. Chem.)<br/> Clemence Queffelec, Org. Biomol. Chem., 2010, DOI: 10.1039/b917428a<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Facile P,N-heterocycle synthesis via tandem aminomethylation-cyclization of H-phosphinate building blocks Clemence Queffelec Jean-Luc Montchamp 10.1039/b917428a Org. Biomol. Chem., 2010, DOI: 10.1039/b917428a html/pdf 2009-11-05 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b917428a http://xlink.rsc.org/?DOI=b910561a&RSS=1 Gd[middle dot]DOTA[middle dot]Rhoda[middle dot]DSA: a novel bimodal lipidic MRI contrast agent.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b910561a-ga.gif"/> </p>Nazila Kamaly, Tammy Kalber, Gavin Kenny, Jimmy Bell, Michael Jorgensen, Andrew Miller <br/> (Paper from Org. Biomol. Chem.)<br/> Nazila Kamaly, Org. Biomol. Chem., 2010, DOI: 10.1039/b910561a<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry A novel bimodal lipidic contrast agent for cellular labelling and tumour MRI Nazila Kamaly Tammy Kalber Gavin Kenny Jimmy Bell Michael Jorgensen Andrew Miller 10.1039/b910561a Org. Biomol. Chem., 2010, DOI: 10.1039/b910561a html/pdf 2009-11-05 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b910561a http://xlink.rsc.org/?DOI=b915870g&RSS=1 A review of the progress made in tackling glycosidase inhibition, which has widespread application in a number of diseases, in particular by examining those inhibitors that may mimic the transition state.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b915870g-ga.gif"/> </p>Tracey M. Gloster, Gideon J. Davies <br/> (Perspective from Org. Biomol. Chem.)<br/> Tracey M. Gloster, Org. Biomol. Chem., 2010, DOI: 10.1039/b915870g<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Glycosidase inhibition: assessing mimicry of the transition state Tracey M. Gloster Gideon J. Davies 10.1039/b915870g Org. Biomol. Chem., 2010, DOI: 10.1039/b915870g html/pdf 2009-11-05 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b915870g http://xlink.rsc.org/?DOI=b916113a&RSS=1 Bis-pyridinium and bis-imidazolium cations can be used to link calix[4]pyrrole anion complexes in solution and the solid state as the first step to producing ordered arrays of calixpyrroles for use in new materials applications.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b916113a-ga.gif"/> </p>Claudia Caltagirone, Nathan L. Bill, Dustin E. Gross, Mark E. Light, Jonathan L. Sessler, Philip A. Gale <br/> (Paper from Org. Biomol. Chem.)<br/> Claudia Caltagirone, Org. Biomol. Chem., 2010, DOI: 10.1039/b916113a<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Bis-cation salt complexation by meso-octamethylcalix[4]pyrrole: linking complexes in solution and in the solid state Claudia Caltagirone Nathan L. Bill Dustin E. Gross Mark E. Light Jonathan L. Sessler Philip A. Gale 10.1039/b916113a Org. Biomol. Chem., 2010, DOI: 10.1039/b916113a html/pdf 2009-11-04 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b916113a http://xlink.rsc.org/?DOI=b915877d&RSS=1 One-electron addition to the antituberculosis drug PA-824 in propan-2-ol leads to the release of nitrite. Such conditions may mimic the water-restricting active site of a reducing protein.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b915877d-ga.gif"/> </p>Andrej Maroz, Sujata S. Shinde, Scott G. Franzblau, Zhenkun Ma, William A. Denny, Brian D. Palmer, Robert F. Anderson <br/> (Paper from Org. Biomol. Chem.)<br/> Andrej Maroz, Org. Biomol. Chem., 2010, DOI: 10.1039/b915877d<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Release of nitrite from the antitubercular nitroimidazole drug PA-824 and analogues upon one-electron reduction in protic, non-aqueous solvent Andrej Maroz Sujata S. Shinde Scott G. Franzblau Zhenkun Ma William A. Denny Brian D. Palmer Robert F. Anderson 10.1039/b915877d Org. Biomol. Chem., 2010, DOI: 10.1039/b915877d html/pdf 2009-11-04 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b915877d http://xlink.rsc.org/?DOI=b918091e&RSS=1 ent-Sawaranospirolides C and D are prepared by the electrophilic spirocyclisation of a 3-(dihydropyran-2-yl)propanoic acid derivative.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b918091e-ga.gif"/> </p>Jeremy Robertson, Praful T. Chovatia, Thomas G. Fowler, Jonathan M. Withey, Daniel J. Woollaston <br/> (Paper from Org. Biomol. Chem.)<br/> Jeremy Robertson, Org. Biomol. Chem., 2010, DOI: 10.1039/b918091e<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Oxidative spirocyclisation routes towards the sawaranospirolides. Synthesis of ent-sawaranospirolides C and D Jeremy Robertson Praful T. Chovatia Thomas G. Fowler Jonathan M. Withey Daniel J. Woollaston 10.1039/b918091e Org. Biomol. Chem., 2010, DOI: 10.1039/b918091e html/pdf 2009-11-04 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b918091e http://xlink.rsc.org/?DOI=b914679b&RSS=1 An efficient synthesis of d-2[prime or minute]-deoxy-2[prime or minute],2[prime or minute]-difluoro-4[prime or minute]-thionucleosides is described. The conformations of d-2[prime or minute]-deoxy-2[prime or minute],2[prime or minute]-difluoro-4[prime or minute]-thiouridine were studied by X-ray crystallography, NMR spectroscopy and molecular modeling in an attempt to explore the roles of the two gem-difluorine atoms in the conformer preferences of the thionucleosides.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b914679b-ga.gif"/> </p>Feng Zheng, Lin Fu, Renxiao Wang, Feng-Ling Qing <br/> (Paper from Org. Biomol. Chem.)<br/> Feng Zheng, Org. Biomol. Chem., 2010, DOI: 10.1039/b914679b<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Synthesis and conformational analysis of d-2[prime or minute]-deoxy-2[prime or minute],2[prime or minute]-difluoro-4[prime or minute]-dihydro-4[prime or minute]-thionucleosides Feng Zheng Lin Fu Renxiao Wang Feng-Ling Qing 10.1039/b914679b Org. Biomol. Chem., 2010, DOI: 10.1039/b914679b html/pdf 2009-11-02 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b914679b http://xlink.rsc.org/?DOI=b913064k&RSS=1 This Emerging Area explores how forces and the mechanics of the extracellular matrix affect the formation and maturation of cell-matrix adhesions.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b913064k-ga.gif"/> </p>Dewi Harjanto, Muhammad H. Zaman <br/> (Emerging Area from Org. Biomol. Chem.)<br/> Dewi Harjanto, Org. Biomol. Chem., 2010, DOI: 10.1039/b913064k<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Matrix mechanics and receptor-ligand interactions in cell adhesion Dewi Harjanto Muhammad H. Zaman 10.1039/b913064k Org. Biomol. Chem., 2010, DOI: 10.1039/b913064k html/pdf 2009-11-02 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b913064k http://xlink.rsc.org/?DOI=b915624k&RSS=1 Chemical analysis of a southern Australian sponge, Clathria sp. yielded new examples of the mirabilin class of marine polyketide alkaloid.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b915624k-ga.gif"/> </p>Mohamed El-Naggar, Melissa Conte, Robert J. Capon <br/> (Paper from Org. Biomol. Chem.)<br/> Mohamed El-Naggar, Org. Biomol. Chem., 2010, DOI: 10.1039/b915624k<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Mirabilins revisited: polyketide alkaloids from a southern Australian marine sponge, Clathria sp. Mohamed El-Naggar Melissa Conte Robert J. Capon 10.1039/b915624k Org. Biomol. Chem., 2010, DOI: 10.1039/b915624k html/pdf 2009-10-30 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b915624k http://xlink.rsc.org/?DOI=b915654b&RSS=1 A series of amphiphilic second order nonlinear probes for cell membrane imaging was studied by combined two-photon excited fluorescence (TPEF) and second harmonic generation (SHG) microscopies.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b915654b-ga.gif"/> </p>Cyril Barsu, Rouba Cheaib, Stephane Chambert, Yves Queneau, Olivier Maury, Davy Cottet, Hartmut Wege, Julien Douady, Yann Bretonniere, Chantal Andraud <br/> (Paper from Org. Biomol. Chem.)<br/> Cyril Barsu, Org. Biomol. Chem., 2010, DOI: 10.1039/b915654b<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Neutral push-pull chromophores for nonlinear optical imaging of cell membranes Cyril Barsu Rouba Cheaib Stephane Chambert Yves Queneau Olivier Maury Davy Cottet Hartmut Wege Julien Douady Yann Bretonniere Chantal Andraud 10.1039/b915654b Org. Biomol. Chem., 2010, DOI: 10.1039/b915654b html/pdf 2009-10-30 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b915654b http://xlink.rsc.org/?DOI=b916198h&RSS=1 The total syntheses of stagonolide B and its 4-epimer were carried out to probe into how the relative stereochemistry of allylic hydroxy groups and their protecting groups influence the efficiency of the ring closing metathesis.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b916198h-ga.gif"/> </p>Awadut G. Giri, Mohabul A. Mondal, Vedavati G. Puranik, Chepuri V. Ramana <br/> (Paper from Org. Biomol. Chem.)<br/> Awadut G. Giri, Org. Biomol. Chem., 2010, DOI: 10.1039/b916198h<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Effect of the allylic substituents on ring closing metathesis: the total synthesis of stagonolide B and 4-epi-stagonolide B Awadut G. Giri Mohabul A. Mondal Vedavati G. Puranik Chepuri V. Ramana 10.1039/b916198h Org. Biomol. Chem., 2010, DOI: 10.1039/b916198h html/pdf 2009-10-29 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b916198h http://xlink.rsc.org/?DOI=b918644a&RSS=1 An enantioselective Michael addition reaction of 3-substituted oxindoles to terminal alkenes which realized the construction of an all carbon-substituted quaternary stereocenter has been reported using catalysis by a bifunctional tertiary-amine thiourea organocatalyst.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b918644a-ga.gif"/> </p>Xin Li, Zhi-Guo Xi, Sanzhong Luo, Jin-Pei Cheng <br/> (Paper from Org. Biomol. Chem.)<br/> Xin Li, Org. Biomol. Chem., 2010, DOI: 10.1039/b918644a<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Asymmetric Michael addition reaction of 3-substituted-N-Boc oxindoles to activated terminal alkenes catalyzed by a bifunctional tertiary-amine thiourea catalyst Xin Li Zhi-Guo Xi Sanzhong Luo Jin-Pei Cheng 10.1039/b918644a Org. Biomol. Chem., 2010, DOI: 10.1039/b918644a html/pdf 2009-10-29 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b918644a http://xlink.rsc.org/?DOI=b910170e&RSS=1 Stereochemistry is all-important to enzyme catalysis, so what will isopenicillin N synthase, a key player in penicillin biosynthesis, make of an lll-configured depsipeptide substrate analogue when its natural substrate is an lld-configured tripeptide?<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b910170e-ga.gif"/> </p>Wei Ge, Ian J. Clifton, Jeanette E. Stok, Robert M. Adlington, Jack E. Baldwin, Peter J. Rutledge <br/> (Paper from Org. Biomol. Chem.)<br/> Wei Ge, Org. Biomol. Chem., 2010, DOI: 10.1039/b910170e<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry The crystal structure of an lll-configured depsipeptide substrate analogue bound to isopenicillin N synthase Wei Ge Ian J. Clifton Jeanette E. Stok Robert M. Adlington Jack E. Baldwin Peter J. Rutledge 10.1039/b910170e Org. Biomol. Chem., 2010, DOI: 10.1039/b910170e html/pdf 2009-10-29 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b910170e http://xlink.rsc.org/?DOI=b918179b&RSS=1 Synthesis of dihydrobenzo[b]furan neolignan, dihydrodehydrodiconiferyl alcohol, via a concise route involving Rh2[S-DOSP]4-catalysed intramolecular C-H insertion, is reported. The rac-2,3-trans-epimer is found to have identical spectral data to the earlier reported natural product, lawsonicin, whose structure is revised.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b918179b-ga.gif"/> </p>Junxiu Meng, Tao Jiang, Huma Aslam Bhatti, Bina S. Siddiqui, Sally Dixon, Jeremy D. Kilburn <br/> (Paper from Org. Biomol. Chem.)<br/> Junxiu Meng, Org. Biomol. Chem., 2010, DOI: 10.1039/b918179b<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Synthesis of dihydrodehydrodiconiferyl alcohol: the revised structure of lawsonicin Junxiu Meng Tao Jiang Huma Aslam Bhatti Bina S. Siddiqui Sally Dixon Jeremy D. Kilburn 10.1039/b918179b Org. Biomol. Chem., 2010, DOI: 10.1039/b918179b html/pdf 2009-10-28 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b918179b http://xlink.rsc.org/?DOI=b917450h&RSS=1 C3[prime or minute]-O-Isoxazole conjugated, and C3[prime or minute]-O,N3-bisisoxazole nucleosides and nucleotides are prepared regiospecifically, rapidly and in high yield under atmospheric conditions and in an aqueous environment; the protocol identifies chloramine-T as a practical reagent for in situ nitrile oxide formation, and the alkyne partner may be attached to the sugar residue or the nucleobase.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b917450h-ga.gif"/> </p>Virginie Algay, Ishwar Singh, Frances Heaney <br/> (Paper from Org. Biomol. Chem.)<br/> Virginie Algay, Org. Biomol. Chem., 2010, DOI: 10.1039/b917450h<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Nucleoside and nucleotide analogues by catalyst free Huisgen nitrile oxide-alkyne 1,3-dipolar cycloaddition Virginie Algay Ishwar Singh Frances Heaney 10.1039/b917450h Org. Biomol. Chem., 2010, DOI: 10.1039/b917450h html/pdf 2009-10-28 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b917450h http://xlink.rsc.org/?DOI=b920152a&RSS=1 An efficient multi-catalysis cascade process for the two-step synthesis of highly substituted drug-like carbocycles was achieved through combinations of cascade TCRA/C-allylation/enyne-RCM/Diels-Alder reactions as key steps starting from simple acyclic substrates via amino acid-/self-/base-/ruthenium-/thermal-catalysis.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b920152a-ga.gif"/> </p>Dhevalapally B. Ramachary, Rumpa Mondal, Chintalapudi Venkaiah <br/> (Communication from Org. Biomol. Chem.)<br/> Dhevalapally B. Ramachary, Org. Biomol. Chem., 2010, DOI: 10.1039/b920152a<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Rapid two-step synthesis of drug-like polycyclic substances by sequential multi-catalysis cascade reactions Dhevalapally B. Ramachary Rumpa Mondal Chintalapudi Venkaiah 10.1039/b920152a Org. Biomol. Chem., 2010, DOI: 10.1039/b920152a html/pdf 2009-10-28 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b920152a http://xlink.rsc.org/?DOI=b916021n&RSS=1 Low temperature 1H NMR spectra in solution and X-ray structures of imino derivatives of phenylalanine show clear evidence of a CH-[small pi] interaction involving one topically resolved ortho hydrogen and the face of the phenylalanine ring.<p><img align="center" src="http://www.rsc.org/ejga/OB/2009/b916021n-ga.gif"/> </p>W. Brian Jennings, Noel J. P. McCarthy, Padraig Kelly, John F. Malone <br/> (Paper from Org. Biomol. Chem.)<br/> W. Brian Jennings, Org. Biomol. Chem., 2009, DOI: 10.1039/b916021n<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Topically resolved intramolecular CH-[small pi] interactions in phenylalanine derivatives W. Brian Jennings Noel J. P. McCarthy Padraig Kelly John F. Malone 10.1039/b916021n Org. Biomol. Chem., 2009, DOI: 10.1039/b916021n html/pdf 2009-10-27 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b916021n http://xlink.rsc.org/?DOI=b916601g&RSS=1 Ketimines 1a-f can be reduced with Cl3SiH in the presence of the Lewis-basic N-methylvaline-derived formamide catalyst (5 mol%) anchored to a soluble dendron (11c) with [less-than-or-equal]94% ee; this protocol represents a simplification of the isolation procedure and recovery of the catalyst.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b916601g-ga.gif"/> </p>Marek Figlus, Stuart T. Caldwell, Dawid Walas, Gulen Yesilbag, Graeme Cooke, Pavel Kocovsky, Andrei V. Malkov, Amitav Sanyal <br/> (Paper from Org. Biomol. Chem.)<br/> Marek Figlus, Org. Biomol. Chem., 2010, DOI: 10.1039/b916601g<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Dendron-anchored organocatalysts: the asymmetric reduction of imines with trichlorosilane, catalysed by an amino acid-derived formamide appended to a dendron Marek Figlus Stuart T. Caldwell Dawid Walas Gulen Yesilbag Graeme Cooke Pavel Kocovsky Andrei V. Malkov Amitav Sanyal 10.1039/b916601g Org. Biomol. Chem., 2010, DOI: 10.1039/b916601g html/pdf 2009-10-27 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b916601g http://xlink.rsc.org/?DOI=b917119n&RSS=1 Clickable 2-dicyanomethylene-3-cyano-2,5-dihydrofuran fluorescent dyes presented here enable multimodal bioorthogonal imaging of azide- and alkyne-modified proteins in vitro and in cells.<p><img align="center" src="http://www.rsc.org/ejga/OB/2009/b917119n-ga.gif"/> </p>Lun K. Tsou, Mingzi M. Zhang, Howard C. Hang <br/> (Communication from Org. Biomol. Chem.)<br/> Lun K. Tsou, Org. Biomol. Chem., 2009, DOI: 10.1039/b917119n<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Clickable fluorescent dyes for multimodal bioorthogonal imaging Lun K. Tsou Mingzi M. Zhang Howard C. Hang 10.1039/b917119n Org. Biomol. Chem., 2009, DOI: 10.1039/b917119n html/pdf 2009-10-26 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b917119n http://xlink.rsc.org/?DOI=b917096k&RSS=1 Various aldoximes were converted to either N-acetoxy or N-hydroxy amides in good yield using the hypervalent iodine(iii) reagents (diacetoxyiodo)benzene (DIB) or Koser's reagent [hydroxy(tosyloxy)iodo]benzene (HTIB). A plausible mechanism for this transformation involves the attack of acetate/hydroxy on the intermediate aryl nitrile oxides, which, upon rearrangement, gave the expected N-acetoxy or N-hydroxy amides.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b917096k-ga.gif"/> </p>Harisadhan Ghosh, Bhisma K. Patel <br/> (Paper from Org. Biomol. Chem.)<br/> Harisadhan Ghosh, Org. Biomol. Chem., 2010, DOI: 10.1039/b917096k<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Hypervalent iodine(iii)-mediated oxidation of aldoximes to N-acetoxy or N-hydroxy amides Harisadhan Ghosh Bhisma K. Patel 10.1039/b917096k Org. Biomol. Chem., 2010, DOI: 10.1039/b917096k html/pdf 2009-10-26 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b917096k http://xlink.rsc.org/?DOI=b910976e&RSS=1 Mannosyl glycolipids with perfluoroalkyl membrane anchors have been synthesised and shown to phase-separate into "artificial lipid rafts" in phospholipid vesicles. The affinity of these glycolipids for tetravalent ConA increased with increasing membrane loading, but was insensitive to the lateral distribution of the mannose lipids.<p><img align="center" src="http://www.rsc.org/ejga/OB/2009/b910976e-ga.gif"/> </p>Gavin T. Noble, Sabine L. Flitsch, Kwan Ping Liem, Simon J. Webb <br/> (Paper from Org. Biomol. Chem.)<br/> Gavin T. Noble, Org. Biomol. Chem., 2009, DOI: 10.1039/b910976e<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Assessing the cluster glycoside effect during the binding of concanavalin A to mannosylated artificial lipid rafts Gavin T. Noble Sabine L. Flitsch Kwan Ping Liem Simon J. Webb 10.1039/b910976e Org. Biomol. Chem., 2009, DOI: 10.1039/b910976e html/pdf 2009-10-26 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b910976e http://xlink.rsc.org/?DOI=b919673k&RSS=1 Oxidative lactonization of 1,6- and 1,7-diols under the influence of a catalytic amount of TEMPO in the presence of PhI(OAc)2 afforded seven- and eight-membered lactones, respectively, in good yields. A concise total synthesis of (+/-)-isolaurepan has been achieved based on this methodology.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b919673k-ga.gif"/> </p>Makoto Ebine, Yuto Suga, Haruhiko Fuwa, Makoto Sasaki <br/> (Communication from Org. Biomol. Chem.)<br/> Makoto Ebine, Org. Biomol. Chem., 2010, DOI: 10.1039/b919673k<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Highly efficient synthesis of medium-sized lactones via oxidative lactonization: concise total synthesis of isolaurepan Makoto Ebine Yuto Suga Haruhiko Fuwa Makoto Sasaki 10.1039/b919673k Org. Biomol. Chem., 2010, DOI: 10.1039/b919673k html/pdf 2009-10-26 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b919673k http://xlink.rsc.org/?DOI=b916305k&RSS=1 para-Nitrophenol-tagged sialyl galactosides containing sialic acid derivatives with a hydrogen, a fluorine, a methoxyl or an azido group at C5 were chemoenzymatically synthesized and used as valuable probes in high-throughput substrate specificity studies of sialidases.<p><img align="center" src="http://www.rsc.org/ejga/OB/2009/b916305k-ga.gif"/> </p>Hongzhi Cao, Yanhong Li, Kam Lau, Saddam Muthana, Hai Yu, Jiansong Cheng, Harshal A. Chokhawala, Go Sugiarto, Lei Zhang, Xi Chen <br/> (Paper from Org. Biomol. Chem.)<br/> Hongzhi Cao, Org. Biomol. Chem., 2009, DOI: 10.1039/b916305k<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Sialidase substrate specificity studies using chemoenzymatically synthesized sialosides containing C5-modified sialic acids Hongzhi Cao Yanhong Li Kam Lau Saddam Muthana Hai Yu Jiansong Cheng Harshal A. Chokhawala Go Sugiarto Lei Zhang Xi Chen 10.1039/b916305k Org. Biomol. Chem., 2009, DOI: 10.1039/b916305k html/pdf 2009-10-26 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b916305k http://xlink.rsc.org/?DOI=b915796d&RSS=1 The first total asymmetric synthesis of the poison frog alkaloid (-)-221T, a 5,6,8-trisubstituted indolizidine is described. The key core piperidine ring was constructed via an acid-catalyzed intramolecular cascade Mannich cyclization reaction of an N-sulfinyl syn-[small alpha]-methyl [small beta]-amino ketone and crotonaldehyde.<p><img align="center" src="http://www.rsc.org/ejga/OB/2009/b915796d-ga.gif"/> </p>Franklin A. Davis, Minsoo Song, Hui Qiu, Jing Chai <br/> (Paper from Org. Biomol. Chem.)<br/> Franklin A. Davis, Org. Biomol. Chem., 2009, DOI: 10.1039/b915796d<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Total synthesis of (5R,6R,8R,9S)-(-)-5,9Z-indolizidine 221T using sulfinimine-derived N-sulfinyl [small beta]-amino ketones Franklin A. Davis Minsoo Song Hui Qiu Jing Chai 10.1039/b915796d Org. Biomol. Chem., 2009, DOI: 10.1039/b915796d html/pdf 2009-10-26 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b915796d http://xlink.rsc.org/?DOI=b912411j&RSS=1 The diastereoselective total synthesis of the title compound is described. It is based on a new methodology involving the stereoconvergent preparation of a suitable sugar ring, followed by a selective Vorbruggen glycosylation.<p><img align="center" src="http://www.rsc.org/ejga/OB/2010/b912411j-ga.gif"/> </p>Guillaume Sautrey, Damien Bourgeois, Christian Perigaud <br/> (Paper from Org. Biomol. Chem.)<br/> Guillaume Sautrey, Org. Biomol. Chem., 2010, DOI: 10.1039/b912411j<br/> To cite this article before page numbers are assigned, use the DOI form of citation above. <br/>The content of this RSS Feed (c) The Royal Society of Chemistry Diastereoselective synthesis of (+/-)-1[prime or minute],4[prime or minute]-dimethyluridine Guillaume Sautrey Damien Bourgeois Christian Perigaud 10.1039/b912411j Org. Biomol. Chem., 2010, DOI: 10.1039/b912411j html/pdf 2009-10-26 The Royal Society of Chemistry Copyright (c) 2010 The Royal Society of Chemistry DOI 10.1039/b912411j