Protein Folding, Misfolding and Aggregation: Classical Themes and Novel Approaches
Protein folding and aggregation is the process by which newly synthesized proteins fold into the specific three-dimensional structures defining their biologically active states. It has always been a major focus of research in biochemistry and has often been seen as the unsolved second part of the genetic code. In the last 10 years we have witnessed a quantum leap in the research in this exciting area. Computational methods have improved to the extent of making possible to simulate the complete folding process of small proteins and the early stages of protein aggregation. Experimental methods have evolved to permit resolving fast processes of folding reactions and visualizing single molecules during folding. The findings from these novel experiments and detailed computer simulations have confirmed the main predictions of analytical theory of protein folding. In summary, protein folding research has finally acquired the status of a truly quantitative science, paving the way for more exciting developments in the near future. This unique book covers all the modern approaches and the many advances experienced in the field during the last 10 years. There is also much emphasis on computational methods and studies of protein aggregation which have really flourished in the last decade. It includes chapters in the areas that have witnessed major developments and are written by top experts including:computer simulations of folding, fast folding, single molecule spectroscopy, protein design, aggregation studies (both computational and experimental). Readers will obtain a unique perspective of the problems faced in the biophysical study of protein conformational behaviour in aqueous solution and how these problems are being solved with a multidisciplinary approach that combines theory, experiment and computer simulations. Protein Folding, Misfolding and Aggregation Classical Themes and Novel Approaches is essential reading for graduate students actively involved in protein folding research, other scientists interested in the recent progress of the field and instructors revamping the protein folding section of their biochemistry and biophysics courses.
Protein Folding, Misfolding and Aggregation: Classical Themes and Novel Approaches, The Royal Society of Chemistry, 2008.
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The α-Helix as the Simplest Protein Model: Helix–Coil Theory, Stability, and Designp1-27ByAndrew James DoigAndrew James DoigFaculty of Life Sciences, The University of ManchesterJackson's MillPO Box 88Sackville StreetManchester M60 1QDUKSearch for other works by this author on:
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Chapter 2: Kinetics and Mechanisms of α-Helix Formationp28-48ByUrmi DoshiUrmi DoshiDepartment of Chemistry and Biochemistry, and Center for Biomolecular Structure and Organization, University of MarylandCollege ParkMD 20742USASearch for other works by this author on:
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Chapter 3: The Protein Folding Energy Landscape: A Primerp49-69ByPeter G. WolynesPeter G. WolynesDepartment of Chemistry and Biochemistry, University of CaliforniaSan Diego9500 Gilman DriveLa JollaCA92093-0332USASearch for other works by this author on:
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Chapter 4: Hydrogen Exchange Experiments: Detection and Characterization of Protein Folding Intermediatesp70-84ByYawen BaiYawen BaiLaboratory of Biochemistry, National Cancer InstituteNIHBuilding 37Room 6114EBethesdaMD 20892USASearch for other works by this author on:
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Chapter 5: Statistical Differential Scanning Calorimetry: Probing Protein Folding–Unfolding Ensemblesp85-105ByBeatriz Ibarra-Molero;Beatriz Ibarra-MoleroFacultad de Ciencias, Departamento de Quimica Fisica, Universidad de Granada18071-GranadaSpainSearch for other works by this author on:Jose Manuel Sanchez-RuizJose Manuel Sanchez-RuizFacultad de Ciencias, Departamento de Quimica Fisica, Universidad de Granada18071-GranadaSpainSearch for other works by this author on:
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Chapter 6: Fast Protein Foldingp106-138ByMartin GruebeleMartin GruebeleDepartment of Chemistry, Department of Physics, and Center of Biophysics and Computational Biology, University of IllinoisUrbanaIL61801USASearch for other works by this author on:
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Chapter 7: Single Molecule Spectroscopy in Protein Folding: From Ensembles to Single Moleculesp139-160ByBenjamin SchulerBenjamin SchulerBiochemisches Institut, Universität Zürich, Winterthurerstr. 1908057 ZürichSwitzerlandSearch for other works by this author on:
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Chapter 8: Computer Simulations of Protein Foldingp161-187ByVijay S. Pande;Vijay S. PandeDepartment of Chemistry and Biophysics Program, Stanford UniversityStanfordCA 94305USASearch for other works by this author on:Eric J. Sorin;Eric J. SorinDepartment of Chemistry and Biophysics Program, Stanford UniversityStanfordCA 94305USASearch for other works by this author on:Christopher D. Snow;Christopher D. SnowDepartment of Chemistry and Biophysics Program, Stanford UniversityStanfordCA 94305USASearch for other works by this author on:Young Min RheeYoung Min RheeDepartment of Chemistry and Biophysics Program, Stanford UniversityStanfordCA 94305USASearch for other works by this author on:
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Chapter 9: Protein Design: Tailoring Sequence, Structure, and Folding Propertiesp188-213ByAndreas Lehmann;Andreas LehmannMakineni Theoretical Laboratories, Department of Chemistry, University of PennsylvaniaPhiladelphiaPA19104USASearch for other works by this author on:Christopher J. Lanci;Christopher J. LanciMakineni Theoretical Laboratories, Department of Chemistry, University of PennsylvaniaPhiladelphiaPA19104USASearch for other works by this author on:Thomas J. Petty II;Thomas J. Petty IIMakineni Theoretical Laboratories, Department of Chemistry, University of PennsylvaniaPhiladelphiaPA19104USASearch for other works by this author on:Seung-gu Kang;Seung-gu KangMakineni Theoretical Laboratories, Department of Chemistry, University of PennsylvaniaPhiladelphiaPA19104USASearch for other works by this author on:Jeffery G. SavenJeffery G. SavenMakineni Theoretical Laboratories, Department of Chemistry, University of PennsylvaniaPhiladelphiaPA19104USASearch for other works by this author on:
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Chapter 10: Protein Misfolding and β-Amyloid Formationp214-240ByAlexandra Esteras-Chopo;Alexandra Esteras-ChopoEuropean Molecular Biology Laboratory, Meyerhofstrasse 1D-69117HeidelbergGermanySearch for other works by this author on:Maria Teresa Pastor;Maria Teresa PastorEuropean Molecular Biology Laboratory, Meyerhofstrasse 1D-69117HeidelbergGermanySearch for other works by this author on:Luis SerranoLuis SerranoEuropean Molecular Biology Laboratory, Meyerhofstrasse 1D-69117HeidelbergGermanySearch for other works by this author on:
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Chapter 11: Scenarios for Protein Aggregation: Molecular Dynamics Simulations and Bioinformatics Analysisp241-265ByRuxandra Dima;Ruxandra DimaDepartment of ChemistryUniversity of CincinnatiCincinnatiOH 45221USASearch for other works by this author on:Bogdan Tarus;Bogdan TarusDepartment of Chemistry, Boston University590 Commonwealth AveBostonMA 02215Search for other works by this author on:G. Reddy;G. ReddyDepartment of Chemistry & Biochemistry, University of MarylandCollege ParkMD 20742USASearch for other works by this author on:John E. Straub;John E. StraubDepartment of Chemistry, Boston University590 Commonwealth AveBostonMA 02215Search for other works by this author on:D. ThirumalaiD. ThirumalaiBiophysics Program, Institute of Physical Sciences & Technology, University of MarylandCollege ParkMD 20742Department of Chemistry & Biochemistry, University of MarylandCollege ParkMD 20742USASearch for other works by this author on:
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