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        <p>Generated by SENTERO - Analysis of biochemical networks</p>
        <p>http://www.dbkgroup.org</p>
      </body>
    </notes>
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      <reaction name="R25_IRAK_P_TRAF6_TAK1_TAB2_Dissociation" reversible="false">
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      <reaction name="R26_IRAK_P_TRAF6_TAK1_TAB1_TAB2_Association" reversible="false">
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      <reaction name="R28_IRAK_P_TRAF6_TAK1_TAB2_TAB1_Association" reversible="false">
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          </listOfParameters>
        </kineticLaw>
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      <reaction name="R30_IRAK_P_TRAF6_TAK1_TAB1_TAB2_Auto_phosphorylation" reversible="false">
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            <parameter name="k" value="0.224"/>
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      <reaction name="R31_IRAK_P_TRAF6_TAK1_TAB1_TAB2_P_Dissociation_and_Translocation_to_Cytosol" reversible="false">
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          <specieReference specie="IRAK_P_TRAF6_TAK1_TAB1_TAB2_P" stoichiometry="1"/>
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          <specieReference specie="IRAK" stoichiometry="1"/>
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      <reaction name="R32_TAK1_phosphorylation_and_activation" reversible="false">
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            <parameter name="k" value="0.0613"/>
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        </kineticLaw>
      </reaction>
      <reaction name="R61_MKK3_PP_p38alpha_P_Dissociation" reversible="false">
        <listOfReactants>
          <specieReference specie="MKK3_PP_p38alpha_P" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="p38alpha_P" stoichiometry="1"/>
          <specieReference specie="MKK3_PP" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*MKK3_PP_p38alpha_P">
          <listOfParameters>
            <parameter name="k" value="4.27"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction name="R62_p38alpha_2nd_phosphorylation_by_MKK3" reversible="false">
        <listOfReactants>
          <specieReference specie="MKK3_PP_p38alpha_P" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="p38alpha_PP" stoichiometry="1"/>
          <specieReference specie="MKK3_PP" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*MKK3_PP_p38alpha_P">
          <listOfParameters>
            <parameter name="k" value="0.234"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction name="R63_MKP1_p38alpha_PP_Association" reversible="false">
        <listOfReactants>
          <specieReference specie="MKP1" stoichiometry="1"/>
          <specieReference specie="p38alpha_PP" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="MKP1_p38alpha_PP" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*MKP1*p38alpha_PP">
          <listOfParameters>
            <parameter name="k" value="4.27"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction name="R64_MKP1_p38alpha_PP_Dissociation" reversible="false">
        <listOfReactants>
          <specieReference specie="MKP1_p38alpha_PP" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="MKP1" stoichiometry="1"/>
          <specieReference specie="p38alpha_PP" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*MKP1_p38alpha_PP">
          <listOfParameters>
            <parameter name="k" value="23.4"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction name="R65_p38alpha_1st_dephosphorylation_by_MKP1" reversible="false">
        <listOfReactants>
          <specieReference specie="MKP1_p38alpha_PP" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="MKP1" stoichiometry="1"/>
          <specieReference specie="p38alpha_P" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*MKP1_p38alpha_PP">
          <listOfParameters>
            <parameter name="k" value="0.0427"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction name="R66_MKP1_p38alpha_P_Association" reversible="false">
        <listOfReactants>
          <specieReference specie="MKP1" stoichiometry="1"/>
          <specieReference specie="p38alpha_P" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="MKP1_p38alpha_P" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*MKP1*p38alpha_P">
          <listOfParameters>
            <parameter name="k" value="4.27"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction name="R67_MKP1_p38alpha_P_Dissociation" reversible="false">
        <listOfReactants>
          <specieReference specie="MKP1_p38alpha_P" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="MKP1" stoichiometry="1"/>
          <specieReference specie="p38alpha_P" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*MKP1_p38alpha_P">
          <listOfParameters>
            <parameter name="k" value="23.4"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction name="R68_p38alpha_2nd_dephosphorylation_by_MKP1" reversible="false">
        <listOfReactants>
          <specieReference specie="MKP1_p38alpha_P" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="MKP1" stoichiometry="1"/>
          <specieReference specie="p38alpha" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*MKP1_p38alpha_P">
          <listOfParameters>
            <parameter name="k" value="0.0427"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction name="R69_MKP5_p38alpha_PP_Association" reversible="false">
        <listOfReactants>
          <specieReference specie="MKP5" stoichiometry="1"/>
          <specieReference specie="p38alpha_PP" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="MKP5_p38alpha_PP" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*MKP5*p38alpha_PP">
          <listOfParameters>
            <parameter name="k" value="4.27"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction name="R69_p38alpha_2nd_phosphorylation_by_MKK6" reversible="false">
        <listOfReactants>
          <specieReference specie="MKK6_PP_p38alpha_P" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="p38alpha_PP" stoichiometry="1"/>
          <specieReference specie="MKK6_PP" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*MKK6_PP_p38alpha_P">
          <listOfParameters>
            <parameter name="k" value="0.234"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction name="R70_MKK6_PP_p38alpha_P_Dissociation" reversible="false">
        <listOfReactants>
          <specieReference specie="MKK6_PP_p38alpha_P" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="p38alpha_P" stoichiometry="1"/>
          <specieReference specie="MKK6_PP" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*MKK6_PP_p38alpha_P">
          <listOfParameters>
            <parameter name="k" value="4.27"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction name="R70_MKP5_p38alpha_PP_Dissociation" reversible="false">
        <listOfReactants>
          <specieReference specie="MKP5_p38alpha_PP" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="MKP5" stoichiometry="1"/>
          <specieReference specie="p38alpha_PP" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*MKP5_p38alpha_PP">
          <listOfParameters>
            <parameter name="k" value="23.4"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction name="R71_MKK6_PP_p38alpha_P_Association" reversible="false">
        <listOfReactants>
          <specieReference specie="p38alpha_P" stoichiometry="1"/>
          <specieReference specie="MKK6_PP" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="MKK6_PP_p38alpha_P" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*MKK6_PP*p38alpha_P">
          <listOfParameters>
            <parameter name="k" value="23.4"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction name="R71_p38alpha_1st_dephosphorylation_by_MKP5" reversible="false">
        <listOfReactants>
          <specieReference specie="MKP5_p38alpha_PP" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="MKP5" stoichiometry="1"/>
          <specieReference specie="p38alpha_P" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*MKP5_p38alpha_PP">
          <listOfParameters>
            <parameter name="k" value="0.0427"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction name="R72_MKP5_p38alpha_P_Association" reversible="false">
        <listOfReactants>
          <specieReference specie="MKP5" stoichiometry="1"/>
          <specieReference specie="p38alpha_P" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="MKP5_p38alpha_P" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*MKP5*p38alpha_P">
          <listOfParameters>
            <parameter name="k" value="4.27"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction name="R72_p38alpha_1st_phosphorylation_by_MKK6" reversible="false">
        <listOfReactants>
          <specieReference specie="MKK6_PP_p38alpha" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="p38alpha_P" stoichiometry="1"/>
          <specieReference specie="MKK6_PP" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*MKK6_PP_p38alpha">
          <listOfParameters>
            <parameter name="k" value="0.234"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction name="R73_MKK6_PP_p38alpha_Dissociation" reversible="false">
        <listOfReactants>
          <specieReference specie="MKK6_PP_p38alpha" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="p38alpha" stoichiometry="1"/>
          <specieReference specie="MKK6_PP" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*MKK6_PP_p38alpha">
          <listOfParameters>
            <parameter name="k" value="4.27"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction name="R73_MKP5_p38alpha_P_Dissociation" reversible="false">
        <listOfReactants>
          <specieReference specie="MKP5_p38alpha_P" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="MKP5" stoichiometry="1"/>
          <specieReference specie="p38alpha_P" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*MKP5_p38alpha_P">
          <listOfParameters>
            <parameter name="k" value="23.4"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction name="R74_MKK6_PP_p38alpha_Association" reversible="false">
        <listOfReactants>
          <specieReference specie="p38alpha" stoichiometry="1"/>
          <specieReference specie="MKK6_PP" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="MKK6_PP_p38alpha" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*MKK6_PP*p38alpha">
          <listOfParameters>
            <parameter name="k" value="23.4"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction name="R74_p38alpha_2nd_dephosphorylation_by_MKP5" reversible="false">
        <listOfReactants>
          <specieReference specie="MKP5_p38alpha_P" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="MKP5" stoichiometry="1"/>
          <specieReference specie="p38alpha" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*MKP5_p38alpha_P">
          <listOfParameters>
            <parameter name="k" value="0.0427"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction name="TAK1_P_dephosphorylation_by_PP2Cbeta" reversible="false">
        <listOfReactants>
          <specieReference specie="PP2Cbeta_TAK1_P" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="PP2Cbeta" stoichiometry="1"/>
          <specieReference specie="TAK1" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*PP2Cbeta_TAK1_P">
          <listOfParameters>
            <parameter name="k" value="0.0427"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction name="TAK1_P_dephosphorylation_by_PP2Cepsilon" reversible="false">
        <listOfReactants>
          <specieReference specie="PP2Cepsilon_TAK1_P" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="PP2Cepsilon" stoichiometry="1"/>
          <specieReference specie="TAK1" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*PP2Cepsilon_TAK1_P">
          <listOfParameters>
            <parameter name="k" value="0.0427"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction name="Degradation2" reversible="false">
        <listOfReactants>
          <specieReference specie="ssRNA_TLR7" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <specieReference specie="Sink2" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw formula="k*ssRNA_TLR7">
          <listOfParameters>
            <parameter name="k" value="0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
    </listOfReactions>
  </model>
</sbml>

