2.5 s465 PROTEIN pr15 s35 PROTEIN pr15 s35 ION Fe_super_3+_endsuper_ s250 PROTEIN pr15 s250 ION Fe_super_3+_endsuper_ s51 PROTEIN pr2 s51 ION Fe_super_3+_endsuper_ s69 PROTEIN pr16 s249 PROTEIN pr15 s249 ION Fe_super_3+_endsuper_ s385 ION Fe_super_2+_endsuper_ s150 PROTEIN pr2 s166 PROTEIN pr2 s69 ION Fe_super_2+_endsuper_ s295 ION Fe_super_3+_endsuper_ s166 SIMPLE_MOLECULE PP_IX s166 ION Fe_super_2+_endsuper_ s221 SIMPLE_MOLECULE S s147 ION Fe_super_2+_endsuper_ s147 SIMPLE_MOLECULE S s529 SIMPLE_MOLECULE PP_IX s529 ION Fe_super_2+_endsuper_ s221 ION Fe_super_2+_endsuper_ s150 ION Fe_super_2+_endsuper_ s150 SIMPLE_MOLECULE S s225 SIMPLE_MOLECULE PP_IX s225 ION Fe_super_2+_endsuper_ s228 SIMPLE_MOLECULE S s249 PROTEIN pr13 s250 PROTEIN pr13 s465 PROTEIN pr1 s262 PROTEIN pr56 s262 PROTEIN pr13 s295 PROTEIN pr58 s450 ION Fe_super_3+_endsuper_ s295 PROTEIN pr25 s58 PROTEIN pr2 s147 PROTEIN pr2 s450 PROTEIN pr25 s208 PROTEIN pr25 s208 ION Fe_super_3+_endsuper_ s273 PROTEIN pr58 s273 PROTEIN pr25 s273 ION Fe_super_3+_endsuper_ s431 ION Fe_super_3+_endsuper_ s432 SIMPLE_MOLECULE siderophore s444 SIMPLE_MOLECULE siderophore s444 ION Fe_super_3+_endsuper_ s444 PROTEIN pr63 s364 PROTEIN pr14 s364 PROTEIN pr22 s441 PROTEIN pr63 s82 PROTEIN pr12 s83 PROTEIN pr12 s565 PROTEIN pr12 s385 PROTEIN pr30 s228 ION Fe_super_2+_endsuper_ s443 PROTEIN pr63 s431 PROTEIN pr63 s431 SIMPLE_MOLECULE siderophore s443 PROTEIN pr62 s444 PROTEIN pr62 s441 PROTEIN pr62 s427 PROTEIN pr63 s427 PROTEIN pr62 s427 SIMPLE_MOLECULE siderophore s432 PROTEIN pr63 s432 ION Fe_super_3+_endsuper_ s439 PROTEIN pr62 s439 ION Fe_super_3+_endsuper_ s439 PROTEIN pr63 s439 SIMPLE_MOLECULE siderophore s58 ION Fe_super_2+_endsuper_ s450 PROTEIN pr58 s440 PROTEIN pr62 s440 ION Fe_super_3+_endsuper_ s440 PROTEIN pr63 s440 SIMPLE_MOLECULE siderophore s476 PROTEIN pr62 s476 PROTEIN pr63 s476 SIMPLE_MOLECULE siderophore s463 ION Fe_super_2+_endsuper_ s466 PROTEIN pr62 s466 ION Fe_super_3+_endsuper_ s466 PROTEIN pr63 s466 SIMPLE_MOLECULE siderophore s463 PROTEIN pr62 s463 PROTEIN pr63 s463 SIMPLE_MOLECULE siderophore s82 SIMPLE_MOLECULE FeOOH s83 SIMPLE_MOLECULE FeOOH s565 SIMPLE_MOLECULE FeOOH s509 PROTEIN pr69 s509 PROTEIN pr70 s509 SIMPLE_MOLECULE PP_IX s509 ION Fe_super_2+_endsuper_ s492 PROTEIN pr69 s492 PROTEIN pr70 s492 SIMPLE_MOLECULE PP_IX s492 ION Fe_super_2+_endsuper_ s502 SIMPLE_MOLECULE PP_IX s502 PROTEIN pr70 s502 ION Fe_super_2+_endsuper_ s502 PROTEIN pr69 s503 PROTEIN pr69 s503 PROTEIN pr70 s503 SIMPLE_MOLECULE PP_IX s503 ION Fe_super_2+_endsuper_ s219 ION Fe_super_2+_endsuper_ s219 SIMPLE_MOLECULE PP_IX s519 ION Fe_super_2+_endsuper_ s519 SIMPLE_MOLECULE PP_IX s528 PROTEIN pr70 s516 ION Fe_super_2+_endsuper_ s516 SIMPLE_MOLECULE PP_IX s528 ION Fe_super_2+_endsuper_ s528 SIMPLE_MOLECULE PP_IX s554 ION Fe_super_2+_endsuper_ s554 SIMPLE_MOLECULE PP_IX s554 PROTEIN pr72 s502 PROTEIN pr68 s503 PROTEIN pr68 s509 PROTEIN pr68 s562 PROTEIN pr75 s562 PROTEIN pr76 s556 PROTEIN pr75 s556 PROTEIN pr76 s241 PROTEIN pr12 s241 SIMPLE_MOLECULE FeOOH s577 ION Fe_super_2+_endsuper_ s577 PROTEIN pr78 s583 PROTEIN pr79 s583 ION Fe_super_2+_endsuper_ s600 PROTEIN pr86 s600 ION Fe_super_2+_endsuper_ SQUARE SQUARE SQUARE SQUARE SQUARE inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive cell Endosome compartment represents the early, recycling, and late endosome. The pH ranges from 6.5 in the early endosome to 5 in the late endosome. Iron does not fall of LfR or 24p3R in the endosome as a pH lower than 5 is necessary for this process. endosome mitochondrion lysosome Phagosome/Phagolysosome inside PROTEIN pr15 inside DEGRADED sa109_degraded inside PROTEIN pr17 inside COMPLEX Tf-Fe inside ION Fe_super_3+_endsuper_ inside ION Fe_super_2+_endsuper_ inside COMPLEX proteins-Fe_super_2+_endsuper_ inside COMPLEX proteins-Fe_super_3+_endsuper_ inside PROTEIN pr2 inside SIMPLE_MOLECULE O_sub_2_endsub_ inside COMPLEX cytoplasmic_br_aconitase inside PROTEIN pr16 inside COMPLEX LOW_Iron_br_Ferritin inside COMPLEX HIGH_Iron_br_Ferritin inside ION Fe_super_3+_endsuper_ inside ION Fe_super_3+_endsuper_ inside ION Fe_super_2+_endsuper_ inside PROTEIN pr23 inside PROTEIN pr31 inside ION Fe_super_2+_endsuper_ inside SIMPLE_MOLECULE O_sub_2_endsub_ inside DEGRADED sa109_degraded inside COMPLEX proteins-Fe-S inside COMPLEX proteins-Fe-S inside PROTEIN pr2 inside COMPLEX heme-proteins 5-aminolevulinate synthase inside PROTEIN pr38 name: protoporphyrin IX inside SIMPLE_MOLECULE PP_IX inside SIMPLE_MOLECULE glycine inside SIMPLE_MOLECULE succinyl_br_CoA name: 5-aminolevulinic acid inside SIMPLE_MOLECULE ALA inside PROTEIN pr40 name: delta-aminolevulinic acid inside SIMPLE_MOLECULE ALA name: coproporphyrinogen III inside SIMPLE_MOLECULE COPRO_III name: protoporphyrinogen IX inside SIMPLE_MOLECULE PPG_IX name: prophobilinogen inside SIMPLE_MOLECULE PBG name: uroporphyrinogen III inside SIMPLE_MOLECULE URO_III name: hydroxymethylbilane inside SIMPLE_MOLECULE HMB name: hydroxymethylbilane synthase inside PROTEIN pr44 name: uroporphyrinogen III synthase inside PROTEIN pr45 uroporphyrinogen decarboxylase inside PROTEIN pr46 name: protoporphyriogen oxidase inside PROTEIN pr47 name: coproporphyrinogen oxidase inside PROTEIN pr48 name: delta-aminolevulinate dehydratase inside PROTEIN pr50 inside COMPLEX Lf-Fe inside SIMPLE_MOLECULE O_sub_2_endsub_ inside SIMPLE_MOLECULE S inside COMPLEX heme inside COMPLEX Fe-S inside COMPLEX heme inside COMPLEX Fe-S inside GENE gn3 name: coproporphyrinogen III inside SIMPLE_MOLECULE COPRO_III outerSurface PROTEIN pr53 inside COMPLEX Ferritin_Iron inside ION Fe_super_2+_endsuper_ transmembrane PROTEIN pr13 transmembrane COMPLEX TfR1-Tf-Fe inside COMPLEX TfR1-Tf-Fe innerSurface PROTEIN pr56 transmembrane COMPLEX HFE-TfR1 found in intestinal epithelial cells outerSurface PROTEIN pr57 transmembrane COMPLEX LfR-Lf-Fe transmembrane PROTEIN pr58 inside PROTEIN pr25 inside GENE gn4 inside COMPLEX LfR-Lf-Fe inside SIMPLE_MOLECULE siderophore transmembrane PROTEIN pr14 inside PROTEIN pr14 inside PROTEIN pr27 inside PROTEIN pr22 inside COMPLEX Fpn-Hepc inside RNA rn6 transmembrane PROTEIN pr26 inside PROTEIN pr63 inside PROTEIN pr20 inside RNA rn4 inside PROTEIN pr41 inside PROTEIN pr42 inside RNA rn5 inside PROTEIN pr12 inside RNA rn2 inside GENE gn2 inside COMPLEX Fxn-Fe inside PROTEIN pr30 inside PROTEIN pr35 inside PROTEIN pr22 inside SIMPLE_MOLECULE siderophore transmembrane PROTEIN pr62 inside COMPLEX NGAL+R+sid inside COMPLEX exported_br_Fe-NGAL inside COMPLEX Fe-NGAL inside COMPLEX imported_br_Fe-NGAL+R inside COMPLEX Fe-NGAL+R inside COMPLEX NGAL+R transmembrane COMPLEX NGAL+R transmembrane COMPLEX Fe-NGAL+R inside ION Fe_super_3+_endsuper_ inside ION Fe_super_2+_endsuper_ inside SIMPLE_MOLECULE cysteine inside COMPLEX LfR-Lf-Fe transmembrane PROTEIN pr65 inside RNA rn9 transmembrane PROTEIN pr66 inside COMPLEX Fe_super_+2_endsuper_-NGAL+R_br_pH<5 inside COMPLEX TfR1-Tf_br_pH=5.5 inside COMPLEX imported_br_Fe-NGAL+R inside COMPLEX NGAL+R+sid inside ION Fe_super_3+_endsuper_ inside COMPLEX Hp-Hb transmembrane COMPLEX Hp-Hb-CD163 inside COMPLEX Hp-Hb-CD163 inside COMPLEX Hp-Hb-CD163 inside COMPLEX heme inside COMPLEX heme inside COMPLEX Hb inside COMPLEX heme inside DEGRADED sa109_degraded inside COMPLEX ROS_br__br_ inside COMPLEX ROS_br_ innerSurface PROTEIN pr71 inside ION Fe_super_2+_endsuper_ inside PROTEIN pr72 transmembrane PROTEIN pr68 inside PROTEIN pr74 inside COMPLEX inactive_HRI transmembrane PROTEIN pr75 transmembrane COMPLEX RBC+receptor inside PROTEIN pr76 inside COMPLEX RBC+receptor inside COMPLEX Ferritin_Iron inside GENE gn5 inside PROTEIN pr78 inside COMPLEX cytoplasmic_br_aconitase* inside GENE gn7 inside GENE gn8 inside PROTEIN pr79 inside COMPLEX active_br_PHD inside PROTEIN pr80 inside PROTEIN pr81 inside PROTEIN pr82 inside PROTEIN pr83 inside SIMPLE_MOLECULE 2-oxoglutarate inside SIMPLE_MOLECULE CO_sub_2_endsub_ inside SIMPLE_MOLECULE succinate inside RNA rn10 inside PROTEIN pr84 inside PROTEIN pr86 inside COMPLEX active_FIH1 PMID: 10522551 TRANSLATIONAL_ACTIVATION sa27 sa28 sa26 sa54 sa326 PMID: 10522551 TRANSLATIONAL_ACTIVATION sa29 sa30 sa26 sa54 sa326 PMID: 16054062 PMID: 10747949 TRANSPORT 0.2383993216963315,0.011903191343204611 0.8125543951350418,0.004835129845402575 sa34 sa39 sa36 PMID: 14729944 STATE_TRANSITION sa26 sa25 sa34 PMID: 14769051 STATE_TRANSITION 0.29259927367599436,-0.550470022204375 0.9845895444603894,-0.46498564414815213 sa28 csa7 csa8 STATE_TRANSITION 0.09932732443790393,0.05048349440380351 0.6680537121673055,0.04220876430885934 0.8097315806602233,-0.0697208269070222 0.98128224357251,-0.07102259703139824 sa34 sa48 csa12 STATE_TRANSITION 0.6656283493417394,0.10748985729969229 0.8615987479533473,0.003470910350286349 0.977926063024651,0.025453148658570957 sa38 sa48 csa10 PMID: 10401608 STATE_TRANSITION 0.898506997975959,-0.41333415071003543 1.242463226471541,-0.10300983064484726 sa34 csa9 sa38 csa9 PMID: 8668195 PMID: 10522551 PMID: 1946430 PMID: 1502165 PMID: 1447194 PMID: 8269957 STATE_TRANSITION -0.09890818145574665,-0.021712527324192266 0.019544829048871337,-0.26423637962311397 0.8580390752789604,0.12026775190943217 csa13 sa34 sa54 csa9 PMID: 10522551 PMID: 1946430 PMID: 1502165 PMID: 1447194 PMID: 8269957 STATE_TRANSITION 0.1545259518390103,-0.15826994414960893 0.873490162759692,0.06651304877779074 sa34 sa54 csa13 PMID: 12627982 PMID: 10441528 PMID: 15771525 PMID: 17881115 STATE_TRANSITION 0.11078878183908247,-0.105278191319913 0.5602791926105466,-0.1618920900890739 1.061060199303156,-0.052972194052258725 1.0661554501923831,-0.012518057082830492 sa34 sa30 sa52 csa14 csa9 PMID: 12627982 PMID: 10441528 PMID: 15771525 PMID: 17881115 STATE_TRANSITION 0.1536232744323136,-0.18160539330677938 0.7463692811144453,-0.31540496787406624 1.058840397006361,-0.1434336569577246 sa34 csa14 sa52 csa15 csa9 PMID: 12627982 PMID: 15771525 PMID: 17881115 STATE_TRANSITION 0.33961524972565127,-0.11214855824800463 sa34 csa9 csa15 csa15 PMID: 12627982 PMID: 10441528 PMID: 15771525 PMID: 17881115 STATE_TRANSITION 0.23885068937815657,-0.18771028243737575 0.8321545923732137,-0.23470150732890982 1.064368849761312,-0.028060709814637264 sa34 csa15 sa52 csa15 csa9 PMID: 5925868 PMID: 6027241 PMID: 9988272 STATE_TRANSITION sa39 sa76 sa61 sa63 sa78 PMID: 16793765 STATE_TRANSITION 0.7488393934201509,0.5044106287008415 1.0396965291659042,0.040843018202073034 sa61 sa24 csa7 TRANSPORT csa8 csa16 PMID: 1988034 PMID: 16564538 PMID: 16271884 STATE_TRANSITION 0.44481082204142197,0.018679963254609966 csa16 sa69 csa6 enzyme is tissue specific--could be Steap2 or Steap4, two homologs of Steap3 PMID: 16227996 STATE_TRANSITION sa69 sa70 PMID: 17109629 PMID: 16475818 TRANSPORT 0.402705832423478,-0.02524526941898042 sa70 sa34 sa64 PMID: 10913165 TRANSCRIPTIONAL_ACTIVATION sa72 sa29 csa9 PMID: 15514116 STATE_TRANSITION 0.8511398798242049,0.1065131049391963 sa65 sa36 csa17 PMID: 15514116 STATE_TRANSITION csa17 sa75 PMID: 17541408 TRANSPORT sa36 sa100 sa78 PMID: 17632513 TRANSPORT sa81 sa36 sa71 TRANSPORT 0.010283345693234969,0.055291843053360434 csa32 csa30 mitoferrin exists in human erythroids, not sure about other human tissue/cells PMID: 16511496 PMID: 16843431 TRANSPORT 0.28938315550296734,-0.42982315555250866 0.6109579688599265,-0.7043715539056039 0.9261802040060689,-0.3351560274587217 0.8274153396777941,-0.20965107893113494 0.9596053092552093,-0.05481876138889347 sa34 sa89 PMID: 12785837 PMID: 12221295 PMID: 17476391 STATE_TRANSITION -0.02574399692411955,-0.6045781774370358 0.4423253465868786,-0.6104118644798344 0.8562612874411073,-0.2644643330090375 sa89 sa84 csa18 PMID: 12785837 PMID: 12221295 PMID: 16517407 PMID: 17476391 STATE_TRANSITION 0.528192019060441,0.1095417923275317 0.8317767951556103,0.013177995023745837 csa18 sa154 sa84 csa32 sa88 PMID: 10942769 PMID: 16475818 TRANSPORT 0.20739777111922864,-0.004154640278881128 0.7383694741591637,-0.00674016020387791 sa39 sa34 sa98 PMID: 17541408 STATE_TRANSITION sa100 sa75 PMID: 9806901 PMID: 16611735 STATE_TRANSITION 0.011177720407420821,0.15775638242889012 csa21 sa75 sa258 PMID: 9806901 PMID: 16611735 TRANSPORT 0.20576899064141618,0.40346355019898605 csa15 csa21 PMID: 9806901 PMID: 16611735 TRANSPORT 0.09969751490791046,0.2955314471887608 csa14 csa21 STATE_TRANSITION -0.014872364039955066,0.061265260821309564 0.8219755826858917,0.12563817980022463 csa30 sa48 csa22 PMID: 17476391 PMID: 15123683 MetaCyc pathway heme biosynthesis II http://metacyc.org STATE_TRANSITION 0.36961543389176565,0.07117178790445955 0.5689870791447791,-0.17254036213578416 csa18 sa123 sa84 csa31 sa108 PMID: 17194590 (a review) The protein which transports heme into cytosol is not determined. Three proteins are possible: ABCG2 ABC-me FLVCR TRANSPORT 0.26776149259108273,-0.4551649112162388 csa31 csa29 STATE_TRANSITION 0.3789532808797529,0.536414530777555 1.0635268482742322,0.057796112727667825 1.0109314177192994,-0.017431751821175734 sa48 csa29 csa25 PMID: 7354050 PMID: 15482256 PMID: 15496594 TRANSPORT sa120 sa118 csa29 TRANSLATIONAL_ACTIVATION sa121 sa120 csa29 Metacyc pathway: tetrapyrrole biosynthesis II http://metacyc.org STATE_TRANSITION sa125 sa124 sa126 sa118 TRANSPORT sa126 sa135 PMID: 17368550 TRANSPORT sa136 sa137 MetaCyc Pathway heme biosynthesis II http://metacyc.org STATE_TRANSITION sa137 sa153 sa138 sa147 MetaCyc pathway heme biosynthesis II http://metacyc.org STATE_TRANSITION sa138 sa153 sa123 sa146 MetaCyc pathway tetrapyrrole biosynthesis II http://metacyc.org STATE_TRANSITION sa135 sa139 sa149 MetaCyc pathway tetrapyrrole biosynthesis II http://metacyc.org STATE_TRANSITION sa139 sa141 sa143 MetaCyc pathway tetrapyrrole biosynthesis II http://metacyc.org STATE_TRANSITION sa141 sa140 sa144 MetaCyc pathway: heme biosynthesis II http://metacyc.org STATE_TRANSITION sa140 sa136 sa145 PMID: 4390967 This reaction has additional reactants and products. NADPH is also a reactant. CO, H2O, NADP+, and Biliverdin are products. In a second reaction, Biliverdin is converted to Bilirubin (an anti-oxidant). This second reaction has NADPH as a product, NADP+ as a reactant, and is catalyzed by biliverdin reductase. STATE_TRANSITION 0.44228744616365945,-0.1962194927420544 0.5226478402208996,-0.23492555046451624 0.68779544666971,-0.3013278254795053 csa29 sa150 sa34 sa122 sa127 PMID: 9652407 PMID: 9427294 PMID: 10828980 PMID: 15222467 STATE_TRANSITION 0.0987455322048767,-0.624082567739638 sa61 sa80 csa28 PMID: 1988141 PMID: 2388632 PMID: 3345742 PMID: 17064313 TRANSCRIPTIONAL_ACTIVATION sa171 sa122 csa9 csa29 sa127 sa338 sa346 PMID: 16402910 PMID: 15044468 PMID: 17368550 PMID: 15369674 TRANSPORT 0.48452003042220393,7.78674268264723E-6 csa29 csa33 sa176 PMID: 14568251 PMID: 10882071 TRANSLATIONAL_ACTIVATION sa177 sa81 sa54 sa26 sa326 PMID: 14769051 STATE_TRANSITION 0.2684607948663431,-0.0703137120118078 0.32460118215197786,-0.07957310375617999 0.8757832286065361,-0.20232996100956635 csa6 sa24 sa28 PMID: 11800564 PMID: 10638746 PMID: 10085150 STATE_TRANSITION 0.9925773134745555,-0.3025512440676721 sa28 sa187 csa37 PMID: 17156779 PMID: 16143108 PMID: 16143096 TRANSPORT 0.5000719524972772,-0.005997588805180865 csa33 csa29 sa190 PMID: 11747454 PMID: 15222483 STATE_TRANSITION sa194 csa28 csa38 PMID: 15975920 PMID: 15998830 PMID: 16604073 PMID: 16801541 PMID: 17264300 PMID: 17607365 TRANSCRIPTIONAL_ACTIVATION sa197 sa198 sa338 csa9 sa346 TRANSLATIONAL_ACTIVATION sa202 sa98 sa26 sa54 sa326 TRANSPORT sa198 sa65 PMID: 16261254 TRANSPORT csa38 csa41 PMID: 16261254 TRANSPORT 0.019721708344135003,0.1974612524534497 0.6944102520382089,0.3954788885569067 csa41 csa44 PMID: 16261254 PMID: 15222467 PMID: 11023790 STATE_TRANSITION 0.5450423346968272,0.05763244846554283 csa44 sa257 sa75 STATE_TRANSITION 0.8440243405909529,0.07700176776106574 sa61 sa218 sa219 csa46 PMID: 16377569 STATE_TRANSITION 0.5281435612283563,0.4301276380639436 sa220 sa219 csa45 PMID: 15282194 STATE_TRANSITION sa220 csa46 csa48 PMID: 16377569 TRANSPORT csa45 csa49 PMID: 15282194 TRANSPORT csa48 csa53 PMID: 16377569 STATE_TRANSITION 0.04393126012515314,-0.12706076681173073 csa49 sa251 csa55 PMID: 16377569 STATE_TRANSITION 0.0920626049504577,-0.044728955430505035 0.16913463140758622,-0.008179405996436406 0.3110214964172642,0.026508915180802894 0.5362039660056658,-0.2805665722379602 0.8576478279261153,-0.05089203081537663 sa38 csa55 csa50 STATE_TRANSITION 0.5834466409257927,-0.08820994945507987 csa50 csa47 sa220 PMID: 18259769 STATE_TRANSITION sa257 sa258 sa259 PMID: 9806901 PMID: 16611735 PMID: 18259769 PMID: 16261254 TRANSPORT 0.36167826370820055,-0.38846129883329605 0.8761823207350172,0.05518310628890444 sa258 sa34 STATE_TRANSITION csa53 csa56 STATE_TRANSITION 0.13371121787115547,0.020524430004946304 0.2212698302975833,-0.18316455258701136 0.7452390004493139,-0.13892441157156177 csa56 csa58 sa70 TRANSPORT 0.36096578921567724,7.486355267787292E-4 0.8178164797135656,-0.020516448120967423 csa53 csa57 STATE_TRANSITION 0.8588744188826785,0.18258835292807074 csa57 sa258 csa58 STATE_TRANSITION csa58 sa75 STATE_TRANSITION csa32 sa107 csa23 STATE_TRANSITION 0.6771088898948037,-0.507811796201643 sa89 csa60 sa277 csa60 STATE_TRANSITION sa278 csa62 csa63 TRANSPORT csa63 csa64 TRANSPORT 0.21914946946277292,0.11464338429832577 0.8583006099089303,0.21072492828696376 csa64 csa65 STATE_TRANSITION 0.15060759087096987,-0.055181028175801394 csa65 csa67 sa75 TRANSPORT 0.04719800233402327,0.13169212210752085 0.300108645681499,0.28228328821164406 0.6133343418586465,-0.21636699057356268 0.9447103764793188,-0.024993246291010185 csa67 csa29 STATE_TRANSITION csa70 csa71 sa307 TRANSPORT -0.14531632036035158,-0.12848066322553953 0.30877581961107325,-0.6281607936271474 csa71 csa29 TRANSPORT 0.11056588333776585,0.09644014925894018 0.23382778729053677,0.07416430663852935 0.8353951892760072,-0.05007359303137182 sa309 sa34 sa308 STATE_TRANSITION 0.2598097592501638,0.005455909586398633 csa71 sa309 sa307 STATE_TRANSITION 0.9450774282692365,0.09612813871706605 0.9557469696759973,-0.01635800936190357 csa29 sa310 csa72 STATE_TRANSITION -0.028682238389584835,-0.015829549805808973 csa72 csa29 sa310 TRANSPORT sa278 sa315 STATE_TRANSITION sa316 sa318 csa73 TRANSPORT 0.7346577884510381,-0.0055889095077006345 csa73 csa75 sa310 STATE_TRANSITION 0.6225564784214228,-0.3903431833380324 csa75 csa70 sa307 TRANSPORT csa14 csa76 TRANSPORT csa15 csa76 TRANSCRIPTIONAL_ACTIVATION sa325 sa202 STATE_TRANSITION 0.16296627727419288,-0.12192465692447074 0.6921707859249828,0.21558416826217264 0.9281038557493786,-0.026958111728540013 sa34 sa326 csa77 STATE_TRANSITION -0.1429485506706416,-0.1295847508936353 0.19798018439441112,-0.5132008830723379 0.849967394879843,0.04080567047390893 csa77 sa34 sa326 csa9 TRANSCRIPTIONAL_ACTIVATION sa333 sa27 sa338 sa346 TRANSCRIPTIONAL_ACTIVATION sa334 sa84 sa339 STATE_TRANSITION 0.6869507327948536,-0.003725594416357225 0.8275448159700205,-0.009733685077724763 sa34 sa335 csa78 STATE_TRANSITION 0.5243589743589729,0.1384615384615384 0.5243589743589738,0.1384615384615384 sa338 sa342 sa150 sa340 sa343 sa344 csa78 STATE_TRANSITION 0.35074784074152054,0.0031598904571303876 0.35074784074152054,0.0031598904571303876 sa339 sa342 sa150 sa341 sa343 sa344 csa78 TRANSLATIONAL_ACTIVATION sa345 sa339 sa26 sa326 sa54 STATE_TRANSITION 0.9326223238854916,-0.11817569227577973 0.9798160445771136,-0.056611845592890564 sa34 sa347 csa79 STATE_TRANSITION 0.7333333333333334,0.13333333333333286 0.7333333333333334,0.13333333333333286 sa338 sa342 sa150 sa346 sa343 sa344 csa79 STATE_TRANSITION sa340 sa350 STATE_TRANSITION sa341 sa350