2.5 s465 PROTEIN pr15 s35 PROTEIN pr15 s35 ION Fe_super_3+_endsuper_ s250 PROTEIN pr15 s250 ION Fe_super_3+_endsuper_ s51 PROTEIN pr2 s51 ION Fe_super_3+_endsuper_ s69 PROTEIN pr16 s249 PROTEIN pr15 s249 ION Fe_super_3+_endsuper_ s150 PROTEIN pr2 s166 PROTEIN pr2 s69 ION Fe_super_2+_endsuper_ s166 SIMPLE_MOLECULE PP_IX s166 ION Fe_super_2+_endsuper_ s221 SIMPLE_MOLECULE S s147 ION Fe_super_2+_endsuper_ s147 SIMPLE_MOLECULE S s219 SIMPLE_MOLECULE PP_IX s219 ION Fe_super_2+_endsuper_ s150 ION Fe_super_2+_endsuper_ s150 SIMPLE_MOLECULE S s225 SIMPLE_MOLECULE PP_IX s225 ION Fe_super_2+_endsuper_ s228 SIMPLE_MOLECULE S s234 ION Fe_super_2+_endsuper_ s234 SIMPLE_MOLECULE PP_IX s249 PROTEIN pr13 s250 PROTEIN pr13 s465 PROTEIN pr1 s58 PROTEIN pr2 s147 PROTEIN pr2 s208 PROTEIN pr25 s208 ION Fe_super_3+_endsuper_ s431 ION Fe_super_3+_endsuper_ s432 SIMPLE_MOLECULE siderophore s444 SIMPLE_MOLECULE siderophore s444 ION Fe_super_3+_endsuper_ s444 PROTEIN pr63 s441 PROTEIN pr63 s82 PROTEIN pr12 s83 PROTEIN pr12 s535 PROTEIN pr12 s228 ION Fe_super_2+_endsuper_ s443 PROTEIN pr63 s431 PROTEIN pr63 s431 SIMPLE_MOLECULE siderophore s443 PROTEIN pr62 s444 PROTEIN pr62 s441 PROTEIN pr62 s427 PROTEIN pr63 s427 PROTEIN pr62 s427 SIMPLE_MOLECULE siderophore s432 PROTEIN pr63 s432 ION Fe_super_3+_endsuper_ s439 PROTEIN pr62 s439 ION Fe_super_3+_endsuper_ s439 PROTEIN pr63 s439 SIMPLE_MOLECULE siderophore s58 ION Fe_super_2+_endsuper_ s440 PROTEIN pr62 s440 ION Fe_super_3+_endsuper_ s440 PROTEIN pr63 s440 SIMPLE_MOLECULE siderophore s476 PROTEIN pr62 s476 PROTEIN pr63 s476 SIMPLE_MOLECULE siderophore s463 ION Fe_super_2+_endsuper_ s466 PROTEIN pr62 s466 ION Fe_super_3+_endsuper_ s466 PROTEIN pr63 s466 SIMPLE_MOLECULE siderophore s463 PROTEIN pr62 s463 PROTEIN pr63 s463 SIMPLE_MOLECULE siderophore s82 SIMPLE_MOLECULE FeOOH s83 SIMPLE_MOLECULE FeOOH s535 SIMPLE_MOLECULE FeOOH s221 ION Fe_super_2+_endsuper_ s553 ION Fe_super_2+_endsuper_ s553 SIMPLE_MOLECULE PP_IX s553 PROTEIN pr68 s529 ION Fe_super_2+_endsuper_ s529 SIMPLE_MOLECULE PP_IX s528 ION Fe_super_2+_endsuper_ s528 SIMPLE_MOLECULE PP_IX s528 PROTEIN pr70 s534 ION Fe_super_2+_endsuper_ s534 SIMPLE_MOLECULE PP_IX s534 PROTEIN pr69 s534 PROTEIN pr70 s533 PROTEIN pr71 s533 PROTEIN pr69 s529 PROTEIN pr69 s533 ION Fe_super_2+_endsuper_ s533 SIMPLE_MOLECULE PP_IX s547 PROTEIN pr12 s547 SIMPLE_MOLECULE FeOOH s547 PROTEIN pr72 s543 PROTEIN pr12 s543 SIMPLE_MOLECULE FeOOH s543 PROTEIN pr72 s241 PROTEIN pr12 s241 SIMPLE_MOLECULE FeOOH s541 PROTEIN pr72 s541 PROTEIN pr12 s541 SIMPLE_MOLECULE FeOOH s559 ION Fe_super_2+_endsuper_ s559 PROTEIN pr73 s570 PROTEIN pr78 s570 ION Fe_super_2+_endsuper_ s579 PROTEIN pr79 s579 ION Fe_super_2+_endsuper_ SQUARE SQUARE SQUARE SQUARE inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive cell Endosome compartment represents the early, recycling, and late endosome. The pH ranges from 6.5 in the early endosome to 5 in the late endosome. Iron does not fall of LfR or 24p3R in the endosome as a pH lower than 5 is necessary for this process. endosome mitochondrion lysosome inside PROTEIN pr15 inside DEGRADED sa109_degraded inside PROTEIN pr17 inside COMPLEX Tf-Fe inside ION Fe_super_3+_endsuper_ inside ION Fe_super_2+_endsuper_ inside COMPLEX proteins-Fe_super_2+_endsuper_ inside COMPLEX proteins-Fe_super_3+_endsuper_ inside PROTEIN pr2 inside SIMPLE_MOLECULE O_sub_2_endsub_ inside COMPLEX cytoplasmic_br_aconitase inside PROTEIN pr16 inside COMPLEX LOW_Iron_br_Ferritin inside COMPLEX HIGH_Iron_br_Ferritin inside ION Fe_super_3+_endsuper_ inside ION Fe_super_3+_endsuper_ inside ION Fe_super_2+_endsuper_ transmembrane PROTEIN pr24 inside PROTEIN pr31 inside ION Fe_super_2+_endsuper_ inside SIMPLE_MOLECULE O_sub_2_endsub_ inside DEGRADED sa109_degraded inside COMPLEX proteins-Fe-S inside COMPLEX proteins-Fe-S inside PROTEIN pr2 inside COMPLEX heme-proteins name: protoporphyrin IX inside SIMPLE_MOLECULE PP_IX inside SIMPLE_MOLECULE glycine inside SIMPLE_MOLECULE succinyl_br_CoA name: 5-aminolevulinic acid inside SIMPLE_MOLECULE ALA name: delta-aminolevulinic acid inside SIMPLE_MOLECULE ALA name: coproporphyrinogen III inside SIMPLE_MOLECULE COPRO_III name: protoporphyrinogen IX inside SIMPLE_MOLECULE PPG_IX name: prophobilinogen inside SIMPLE_MOLECULE PBG name: uroporphyrinogen III inside SIMPLE_MOLECULE URO_III name: hydroxymethylbilane inside SIMPLE_MOLECULE HMB name: hydroxymethylbilane synthase inside PROTEIN pr44 name: uroporphyrinogen III synthase inside PROTEIN pr45 uroporphyrinogen decarboxylase inside PROTEIN pr46 name: protoporphyriogen oxidase inside PROTEIN pr47 name: coproporphyrinogen oxidase inside PROTEIN pr48 name: delta-aminolevulinate dehydratase inside PROTEIN pr50 inside COMPLEX Lf-Fe inside SIMPLE_MOLECULE O_sub_2_endsub_ inside SIMPLE_MOLECULE S inside COMPLEX heme inside COMPLEX Fe-S inside COMPLEX heme inside COMPLEX Fe-S inside GENE gn3 transmembrane PROTEIN pr52 inside COMPLEX heme name: coproporphyrinogen III inside SIMPLE_MOLECULE COPRO_III inside COMPLEX Ferritin_Iron inside ION Fe_super_2+_endsuper_ outerSurface PROTEIN pr13 transmembrane COMPLEX TfR1-Tf-Fe inside COMPLEX TfR1-Tf-Fe name: coproporphyrinogen III inside SIMPLE_MOLECULE COPRO_III inside PROTEIN pr25 inside SIMPLE_MOLECULE siderophore inside PROTEIN pr63 inside PROTEIN pr20 inside RNA rn4 inside PROTEIN pr41 inside PROTEIN pr42 inside PROTEIN pr12 inside RNA rn2 inside GENE gn2 transmembrane PROTEIN pr34 inside PROTEIN pr35 inside PROTEIN pr22 inside SIMPLE_MOLECULE siderophore transmembrane PROTEIN pr62 inside COMPLEX NGAL+R+sid inside COMPLEX exported_br_Fe-NGAL inside COMPLEX Fe-NGAL inside COMPLEX imported_br_Fe-NGAL+R inside COMPLEX Fe-NGAL+R inside COMPLEX NGAL+R transmembrane COMPLEX NGAL+R transmembrane COMPLEX Fe-NGAL+R inside ION Fe_super_3+_endsuper_ inside ION Fe_super_2+_endsuper_ inside SIMPLE_MOLECULE cysteine transmembrane PROTEIN pr65 inside RNA rn9 transmembrane PROTEIN pr66 inside COMPLEX Fe_super_+2_endsuper_-NGAL+R_br_pH<5 inside COMPLEX TfR1-Tf_br_pH=5.5 inside COMPLEX imported_br_Fe-NGAL+R inside COMPLEX NGAL+R+sid inside ION Fe_super_3+_endsuper_ inside COMPLEX ROS_br__br_ inside COMPLEX ROS_br_ inside PROTEIN pr38 inside PROTEIN pr40 inside RNA rn5 inside PROTEIN pr68 inside PROTEIN pr69 inside PROTEIN pr70 inside RNA rn10 inside RNA rn11 inside PROTEIN pr71 inside COMPLEX _beta_Hb inside COMPLEX _alpha_Hb inside COMPLEX AHSP+_alpha_Hb inside COMPLEX HbA inside COMPLEX Ferritin_Iron transmembrane PROTEIN pr72 inside COMPLEX Fe+Ft+Ft-R transmembrane COMPLEX Fe+Ft+Ft-R inside COMPLEX Fe+Ft+Ft-R inside COMPLEX inactivate_HRI inside GENE gn5 inside PROTEIN pr73 inside COMPLEX cytoplasmic_br_aconitase* inside PROTEIN pr74 inside PROTEIN pr75 inside PROTEIN pr76 inside PROTEIN pr77 inside SIMPLE_MOLECULE 2-oxoglutarate inside SIMPLE_MOLECULE CO_sub_2_endsub_ inside SIMPLE_MOLECULE succinate inside PROTEIN pr78 inside COMPLEX active_br_PHD inside RNA rn12 inside GENE gn7 inside PROTEIN pr79 inside COMPLEX acive_br_FIH1 inside PROTEIN pr80 PMID: 10522551 TRANSLATIONAL_ACTIVATION 0.08428079867837113,0.27257939592648484 sa27 sa28 sa26 sa54 sa317 PMID: 10522551 TRANSLATIONAL_ACTIVATION sa29 sa30 sa26 sa54 sa317 PMID: 14729944 STATE_TRANSITION sa26 sa25 sa34 PMID: 14769051 STATE_TRANSITION 1.0813234342216282,-0.3661481635570887 sa28 csa7 csa8 STATE_TRANSITION 0.044919125371018664,0.06451979003858677 0.6814942301786349,0.003992463574906235 sa34 sa48 csa12 STATE_TRANSITION 0.3155009296885203,0.059134281497380314 sa38 sa48 csa10 PMID: 10401608 STATE_TRANSITION 0.7203788758491252,0.02708156259019967 0.9121312365074359,0.01612124452815422 sa34 csa9 sa38 csa9 PMID: 8668195 PMID: 10522551 PMID: 1946430 PMID: 1502165 PMID: 1447194 PMID: 8269957 STATE_TRANSITION -0.0919222781080049,0.0384369489640477 0.08538945529420183,-0.27478187628555273 0.8139833225363031,0.1081293125445193 csa13 sa34 sa54 csa9 PMID: 10522551 PMID: 1946430 PMID: 1502165 PMID: 1447194 PMID: 8269957 STATE_TRANSITION 0.24117547138920425,-0.14486876187771758 0.8470865114509034,0.07056192059224475 sa34 sa54 csa13 PMID: 12627982 PMID: 10441528 PMID: 15771525 PMID: 17881115 STATE_TRANSITION 0.18063127716640048,-0.031326940488658916 1.0131704970279976,-0.17571448512774923 1.0234838930736467,-0.11624739799477846 1.0441106851649455,0.0026867762711653143 sa34 sa30 sa52 csa14 csa9 PMID: 12627982 PMID: 10441528 PMID: 15771525 PMID: 17881115 STATE_TRANSITION 0.26723088995839017,-0.05600005141309072 0.9930626396214552,-0.3127824156248513 1.0769818877539106,-0.02585233252631003 sa34 csa14 sa52 csa15 csa9 PMID: 12627982 PMID: 15771525 PMID: 17881115 STATE_TRANSITION 0.8566195313565357,0.3721450139971454 1.1754862288646912,0.33162500388641547 sa34 csa9 csa15 csa15 PMID: 12627982 PMID: 10441528 PMID: 15771525 PMID: 17881115 STATE_TRANSITION 0.3293504841281517,0.1283961638919644 0.8529708012857055,0.3184573089830307 1.1553195659959608,0.2619831304943476 sa34 csa15 sa52 csa15 csa9 PMID: 5925868 PMID: 6027241 PMID: 9988272 STATE_TRANSITION sa39 sa76 sa61 sa63 PMID: 16793765 STATE_TRANSITION 0.7932462620936529,0.45208083903159724 sa61 sa24 csa7 TRANSPORT 0.14917025070806567,0.010414350152103236 csa8 csa16 csa29 PMID: 1988034 PMID: 16564538 PMID: 16271884 STATE_TRANSITION 0.09951879092111682,0.10221876687198073 csa16 sa69 csa6 enzyme is tissue specific--could be Steap2 or Steap4, two homologs of Steap3 PMID: 16227996 STATE_TRANSITION sa69 sa70 sa77 PMID: 17109629 PMID: 16475818 TRANSPORT 0.2138070773864239,0.06322889637826856 0.4055418137862775,-0.16320658558878076 sa70 sa34 sa64 PMID: 10913165 TRANSCRIPTIONAL_ACTIVATION sa72 sa29 csa9 TRANSPORT 0.005168263298531706,0.07176357745457262 csa32 csa30 mitoferrin exists in human erythroids, not sure about other human tissue/cells PMID: 16511496 PMID: 16843431 TRANSPORT 0.615606057985187,-0.003401044161629674 sa34 sa89 sa99 PMID: 12785837 PMID: 12221295 PMID: 16517407 PMID: 17476391 STATE_TRANSITION 0.08993654085251279,0.45307603812281805 0.5730719773001827,0.3234591376470344 0.7500619774805624,0.23480476045928178 sa89 sa154 csa32 sa88 PMID: 9806901 PMID: 16611735 STATE_TRANSITION 0.5709672308079563,0.5144717551532167 csa21 sa75 sa258 PMID: 9806901 PMID: 16611735 TRANSPORT 0.1745150636489854,0.39813302160825004 0.9020647542967084,0.07424540677052394 csa15 csa21 PMID: 9806901 PMID: 16611735 TRANSPORT 0.07465782123265319,0.27194815247278314 0.9246007482161629,0.04016470910929171 csa14 csa21 STATE_TRANSITION 0.042802398599244285,0.22020643196800338 0.6529782237305186,0.100035980838585 csa30 sa48 csa22 PMID: 17476391 PMID: 15123683 MetaCyc pathway heme biosynthesis II http://metacyc.org STATE_TRANSITION -0.015733303425371048,0.41010984581765 0.3610833431553231,0.3819799360394218 0.5537632342545322,0.22365113728597175 0.7785575974971048,0.10335301291877697 sa89 sa123 csa31 sa108 PMID: 17194590 (a review) The protein which transports heme into cytosol is not determined. Three proteins are possible: ABCG2 ABC-me FLVCR TRANSPORT -0.009131123988906253,0.05122104369753511 0.9486001718134263,0.024248219015266192 csa31 csa29 STATE_TRANSITION 0.5920593206746387,0.02141861297207548 sa48 csa29 csa25 PMID: 7354050 PMID: 15482256 PMID: 15496594 TRANSPORT sa120 sa118 TRANSLATIONAL_ACTIVATION sa121 sa120 sa54 sa26 sa317 Metacyc pathway: tetrapyrrole biosynthesis II http://metacyc.org STATE_TRANSITION sa125 sa124 sa126 sa118 TRANSPORT sa126 sa135 PMID: 17368550 TRANSPORT sa136 sa137 MetaCyc Pathway heme biosynthesis II http://metacyc.org STATE_TRANSITION sa137 sa153 sa138 sa147 MetaCyc pathway heme biosynthesis II http://metacyc.org STATE_TRANSITION sa138 sa153 sa123 sa146 MetaCyc pathway tetrapyrrole biosynthesis II http://metacyc.org STATE_TRANSITION sa135 sa139 sa149 MetaCyc pathway tetrapyrrole biosynthesis II http://metacyc.org STATE_TRANSITION sa139 sa141 sa143 MetaCyc pathway tetrapyrrole biosynthesis II http://metacyc.org STATE_TRANSITION sa141 sa140 sa144 MetaCyc pathway: heme biosynthesis II http://metacyc.org STATE_TRANSITION sa140 sa136 sa145 PMID: 4390967 This reaction has additional reactants and products. NADPH is also a reactant. CO, H2O, NADP+, and Biliverdin are products. In a second reaction, Biliverdin is converted to Bilirubin (an anti-oxidant). This second reaction has NADPH as a product, NADP+ as a reactant, and is catalyzed by biliverdin reductase. STATE_TRANSITION 0.10949393847187983,0.08723742597032658 0.520426974015705,-0.001257816470890738 0.5707080023286402,-0.004366174901198505 0.9195668420888654,-0.07640571222631021 csa29 sa52 sa34 sa122 sa127 PMID: 9652407 PMID: 9427294 PMID: 10828980 PMID: 15222467 STATE_TRANSITION 0.4365049981488305,0.05220288781932503 sa61 sa80 csa28 PMID: 1988141 PMID: 2388632 PMID: 3345742 PMID: 17064313 TRANSCRIPTIONAL_ACTIVATION 0.3804449094580029,-0.001863340273054348 sa171 sa122 csa9 csa29 sa127 sa321 sa337 PMID: 16402910 PMID: 15044468 PMID: 17368550 PMID: 15369674 TRANSPORT csa29 csa33 sa172 PMID: 16402910 PMID: 15044468 PMID: 17368550 TRANSPORT 0.45770850679140906,0.003661546964919271 sa136 sa175 sa172 PMID: 14769051 STATE_TRANSITION 0.07267634530393363,-0.17682114985608832 0.3298570909587888,-0.38370242587845427 csa6 sa24 sa28 TRANSLATIONAL_ACTIVATION sa202 sa98 sa26 sa54 sa317 STATE_TRANSITION 0.8049113790631108,0.08305059472135068 sa61 sa218 sa219 csa46 PMID: 16377569 STATE_TRANSITION sa220 sa219 csa45 PMID: 15282194 STATE_TRANSITION sa220 csa46 csa48 PMID: 16377569 TRANSPORT csa45 csa49 PMID: 15282194 TRANSPORT 0.5075451781545217,-0.20624251480310196 csa48 csa53 PMID: 16377569 STATE_TRANSITION 0.16534762499082412,-0.16198516995815204 csa49 sa251 csa55 PMID: 16377569 STATE_TRANSITION 0.3445954113361679,-0.07698289128760016 0.37472464228303326,-0.04992070780238633 0.5150510843816916,-9.020727828312758E-5 0.7351532351036213,-0.2487736320517281 0.9400320055423352,-0.06475078435228421 sa38 csa55 csa50 STATE_TRANSITION 0.4938834283384161,-0.25661991453790023 csa50 csa47 sa220 PMID: 18259769 STATE_TRANSITION sa257 sa258 sa259 PMID: 9806901 PMID: 16611735 PMID: 18259769 PMID: 16261254 TRANSPORT -0.007005183728562958,-0.06957506344052655 0.4173204203065435,-0.4475293791866898 0.8577309575694736,0.01935584099016663 sa258 sa34 STATE_TRANSITION csa53 csa56 STATE_TRANSITION 0.055296939639827514,0.0377111992241681 0.053788487742601365,-0.36341130111341635 0.9062680792035451,-0.3415466051239282 csa56 csa58 sa70 TRANSPORT 0.2479119949535764,-0.0998091446040198 0.8039453849647747,-0.12330959293370158 csa53 csa57 STATE_TRANSITION 0.24293345572933633,0.24470583413611902 csa57 sa258 csa58 STATE_TRANSITION 0.48439310036631333,0.21871208187926827 0.6732580623234705,0.022812698403515075 csa58 sa75 STATE_TRANSITION csa32 sa107 csa23 STATE_TRANSITION 0.22318209370944864,0.05148791943160891 sa89 csa60 sa277 csa60 STATE_TRANSITION 0.8301355158996393,0.02929469117581185 csa29 sa280 csa61 STATE_TRANSITION 0.020254197558730813,0.18272185855919965 csa61 csa29 sa280 TRANSLATIONAL_ACTIVATION sa288 sa282 sa280 TRANSLATIONAL_ACTIVATION sa289 sa283 sa280 STATE_TRANSITION 0.7299821430801314,-0.32939024237959025 0.9514079494511796,0.10961526454464643 csa29 sa282 csa62 STATE_TRANSITION 0.9185395253694217,-0.33396150091924026 1.0546799263273134,0.014601144707868663 csa29 sa283 csa63 STATE_TRANSITION 0.25608046689830033,0.0771537553201398 csa62 sa297 csa65 STATE_TRANSITION 0.5498889482414526,-0.02527481795945974 csa65 csa63 csa64 sa297 STATE_TRANSITION sa304 csa66 csa67 TRANSPORT csa67 csa68 TRANSPORT csa68 csa69 STATE_TRANSITION 0.36020950919172934,-0.2155404455744785 0.47903122237625884,-0.07334703227391337 0.7877713553956011,0.15162893773495556 csa69 sa258 sa75 TRANSCRIPTIONAL_ACTIVATION sa314 sa202 STATE_TRANSITION 0.24380244575521548,-0.06854318593709263 0.6419416230145059,0.24416525655521992 0.9073703722257136,-0.06107464779169203 sa34 sa317 csa70 STATE_TRANSITION -0.0656219043091677,-0.022572362866813522 0.31729195759872986,-0.4324317987678057 0.8475932421373082,0.034576048230990586 csa70 sa34 sa317 csa9 STATE_TRANSITION 0.6596448676647171,0.0013301402245122773 sa34 sa329 csa71 STATE_TRANSITION 1.6100330716818743,-0.45782364426027033 1.6957006813563371,-0.48292624616488045 sa321 sa325 sa52 sa322 sa327 sa326 csa71 STATE_TRANSITION 0.013536133529356675,9.138135257380497E-4 0.721070331159924,-0.005712417253320723 0.7418801605020335,-0.005907306393879708 sa323 sa325 sa52 sa324 sa326 sa327 csa71 TRANSCRIPTIONAL_ACTIVATION sa332 sa27 sa321 sa337 TRANSLATIONAL_ACTIVATION sa331 sa323 sa26 sa317 sa54 STATE_TRANSITION 0.5677172725854245,0.010298018411608822 sa34 sa336 csa72 STATE_TRANSITION 0.46001999191146226,0.1757456906747663 0.5788726698358673,2.517302160194731 0.9103416175135255,2.514555179965358 sa321 sa325 sa52 sa337 sa327 sa326 csa72 STATE_TRANSITION sa322 sa338 STATE_TRANSITION 0.9661525019973407,0.22280405412729376 sa324 sa338