# Suchtgene aus http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371% # Supplementary Table S4: Addiction-related genes for four addictive substances # folgendes Gen geloescht weil kein nCBI index und auch nicht GO-Annotiert: #161060 LOC161060 similar to cytochrome c oxidase subunit III - Yes - - 13 # Entrez Gene ID Official Symbol Gene description Cocaine Alcohol Opioids Nicotine Locations % 386 12 SERPINA3 "serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3" Yes Yes Yes Yes 14q32.1 18 ABAT 4-aminobutyrate aminotransferase Yes Yes - Yes 16p13.2 88 ACTN2 "actinin, alpha 2" Yes Yes Yes Yes 1q42-q43 112 ADCY6 adenylate cyclase 6 - - Yes - 12q12-q13 114 ADCY8 adenylate cyclase 8 (brain) Yes Yes Yes Yes 8q24 143 PARP4 "poly (ADP-ribose) polymerase family, member 4" - Yes - - 13q11 213 ALB albumin Yes - Yes - 4q11-q13 230 ALDOC "aldolase C, fructose-bisphosphate" - Yes Yes - 17cen-q12 231 AKR1B1 "aldo-keto reductase family 1, member B1 (aldose reductase)" Yes Yes Yes Yes 7q35 242 ALOX12B "arachidonate 12-lipoxygenase, 12R type" - Yes - - 17p13.1 347 APOD apolipoprotein D - Yes - - 3q26.2-qter 348 APOE apolipoprotein E Yes Yes - - 19q13.2 351 APP "amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)" Yes Yes - - 21q21.2|21q21.3 358 AQP1 aquaporin 1 (Colton blood group) - Yes - - 7p14 419 ART3 ADP-ribosyltransferase 3 - Yes - - 4p15.1-p14 427 ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 Yes Yes - - 8p22-p21.3 478 ATP1A3 "ATPase, Na+/K+ transporting, alpha 3 polypeptide" Yes - - - 19q13.31 506 ATP5B "ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide" Yes - Yes - 12q13.13 526 ATP6V1B2 "ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2" - Yes Yes - 8p22-p21 529 ATP6V1E1 "ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1" - Yes Yes - 22pter-q11.2|22q11.1 595 CCND1 cyclin D1 - Yes - - 11q13 598 BCL2L1 BCL2-like 1 Yes - - - 20q11.21 627 BDNF brain-derived neurotrophic factor Yes Yes Yes Yes 11p13 687 KLF9 Kruppel-like factor 9 - Yes - - 9q13 725 C4BPB "complement component 4 binding protein, beta" Yes Yes Yes Yes 1q32 760 CA2 carbonic anhydrase II - Yes - - 8q22 776 CACNA1D "calcium channel, voltage-dependent, L type, alpha 1D subunit" - Yes - - 3p14.3 786 CACNG1 "calcium channel, voltage-dependent, gamma subunit 1" - Yes - - 17q24 794 CALB2 "calbindin 2, 29kDa (calretinin)" - Yes - - 16q22.2 796 CALCA "calcitonin/calcitonin-related polypeptide, alpha" - Yes - - 11p15.2-p15.1 805 CALM2 "calmodulin 2 (phosphorylase kinase, delta)" - Yes - - 2p21 815 CAMK2A calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha - - Yes - 5q33.1 826 CAPNS1 "calpain, small subunit 1" Yes Yes - - 19q13.12 832 CAPZB "capping protein (actin filament) muscle Z-line, beta" Yes Yes - - 1p36.1 836 CASP3 "caspase 3, apoptosis-related cysteine peptidase" - - Yes Yes 4q34 885 CCK cholecystokinin Yes Yes - - 3p22-p21.3 1020 CDK5 cyclin-dependent kinase 5 Yes - - - 7q36 1026 CDKN1A "cyclin-dependent kinase inhibitor 1A (p21, Cip1)" - Yes - - 6p21.2 1052 CEBPD "CCAAT/enhancer binding protein (C/EBP), delta" - Yes - - 8p11.2-p11.1 1124 CHN2 chimerin (chimaerin) 2 Yes Yes Yes Yes 7p15.3 1137 CHRNA4 "cholinergic receptor, nicotinic, alpha 4" - - - Yes 20q13.2-q13.3 1139 CHRNA7 "cholinergic receptor, nicotinic, alpha 7" - Yes - - 15q14 1152 CKB "creatine kinase, brain" - Yes - Yes 14q32 1182 CLCN3 chloride channel 3 - Yes - - 4q33 1209 CLPTM1 cleft lip and palate associated transmembrane protein 1 - Yes - - 19q13.2-q13.3 1212 CLTB "clathrin, light polypeptide (Lcb)" Yes - - - 4q2-q3|5q35 1230 CCR1 chemokine (C-C motif) receptor 1 - Yes - - 3p21 1234 CCR5 chemokine (C-C motif) receptor 5 Yes Yes Yes - 3p21 1267 CNP "2',3'-cyclic nucleotide 3' phosphodiesterase" - Yes - Yes 17q21 1268 CNR1 cannabinoid receptor 1 (brain) Yes Yes Yes Yes 6q14-q15 1278 COL1A2 "collagen, type I, alpha 2" - Yes - - 7q22.1 1345 COX6C cytochrome c oxidase subunit VIc Yes Yes - - 8q22-q23 1347 COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) Yes Yes Yes - 6q12 1363 CPE carboxypeptidase E - Yes - - 4q32.3 1366 CLDN7 claudin 7 - Yes - - 17p13 1381 CRABP1 cellular retinoic acid binding protein 1 - Yes - - 15q24 1382 CRABP2 cellular retinoic acid binding protein 2 - Yes - - 1q21.3 1385 CREB1 cAMP responsive element binding protein 1 Yes Yes Yes Yes 2q34 1390 CREM cAMP responsive element modulator - Yes - - 10p11.21 1409 CRYAA "crystallin, alpha A" - Yes - - 21q22.3 1410 CRYAB "crystallin, alpha B" Yes Yes Yes - 11q22.3-q23.1 1428 CRYM "crystallin, mu" - Yes - Yes 16p13.11-p12.3 1490 CTGF connective tissue growth factor - Yes - - 6q23.1 1499 CTNNB1 "catenin (cadherin-associated protein), beta 1, 88kDa" Yes Yes - - 3p21 1501 CTNND2 "catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)" Yes Yes Yes Yes 5p15.2 1548 CYP2A6 "cytochrome P450, family 2, subfamily A, polypeptide 6" - - - Yes 19q13.2 1621 DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) - Yes - - 9q34 1745 DLX1 distal-less homeobox 1 - Yes - - 2q32 1813 DRD2 dopamine receptor D2 Yes Yes Yes Yes 11q23 1814 DRD3 dopamine receptor D3 Yes - - - 3q13.3 1815 DRD4 dopamine receptor D4 Yes Yes Yes Yes 11p15.5 1848 DUSP6 dual specificity phosphatase 6 - Yes - - 12q22-q23 1902 EDG2 "endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2" Yes Yes - - 9q31.3 1958 EGR1 early growth response 1 Yes Yes - - 5q31.1 1959 EGR2 "early growth response 2 (Krox-20 homolog, Drosophila)" Yes - Yes - 10q21.1 2012 EMP1 epithelial membrane protein 1 - Yes - - 12p12.3 2023 ENO1 "enolase 1, (alpha)" Yes Yes - - 1p36.3-p36.2 2026 ENO2 "enolase 2 (gamma, neuronal)" Yes Yes Yes - 12p13 2027 ENO3 "enolase 3 (beta, muscle)" - - Yes - 17pter-p11 2065 ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) - Yes - - 12q13 2119 ETV5 ets variant gene 5 (ets-related molecule) Yes Yes Yes Yes 3q28 2166 FAAH fatty acid amide hydrolase Yes Yes Yes Yes 1p35-p34 2173 FABP7 "fatty acid binding protein 7, brain" - Yes - - 6q22-q23 2247 FGF2 fibroblast growth factor 2 (basic) Yes Yes - - 4q26-q27 2289 FKBP5 FK506 binding protein 5 - Yes - - 6p21.3-21.2 2335 FN1 fibronectin 1 - Yes - - 2q34 2353 FOS v-fos FBJ murine osteosarcoma viral oncogene homolog Yes Yes Yes Yes 14q24.3 2354 FOSB FBJ murine osteosarcoma viral oncogene homolog B Yes Yes Yes Yes 19q13.32 2359 FPRL2 formyl peptide receptor-like 2 - Yes - - 19q13.3-q13.4 2548 GAA "glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II)" Yes Yes - - 17q25.2-q25.3 2550 GABBR1 "gamma-aminobutyric acid (GABA) B receptor, 1" Yes Yes - - 6p21.31 2560 GABRB1 "gamma-aminobutyric acid (GABA) A receptor, beta 1" Yes Yes - - 4p12 2565 GABRG1 "gamma-aminobutyric acid (GABA) A receptor, gamma 1" Yes Yes Yes Yes 4p12 2566 GABRG2 "gamma-aminobutyric acid (GABA) A receptor, gamma 2" - Yes - - 5q31.1-q33.1 2571 GAD1 "glutamate decarboxylase 1 (brain, 67kDa)" Yes - - - 2q31 2597 GAPDH glyceraldehyde-3-phosphate dehydrogenase - Yes Yes - 12p13 2617 GARS glycyl-tRNA synthetase - Yes - - 7p15 2657 GDF1 growth differentiation factor 1 - Yes - - 19p12 2668 GDNF glial cell derived neurotrophic factor Yes - Yes - 5p13.1-p12 2670 GFAP glial fibrillary acidic protein - Yes - - 17q21 2729 GCLC "glutamate-cysteine ligase, catalytic subunit" Yes Yes Yes - 6p12 2746 GLUD1 glutamate dehydrogenase 1 - Yes Yes - 10q23.3 2767 GNA11 "guanine nucleotide binding protein (G protein), alpha 11 (Gq class)" Yes - - - 19p13.3 2770 GNAI1 "guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1" - - Yes - 7q21 2775 GNAO1 "guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O" Yes Yes Yes - 16q13 2776 GNAQ "guanine nucleotide binding protein (G protein), q polypeptide" Yes - - - 9q21 2782 GNB1 "guanine nucleotide binding protein (G protein), beta polypeptide 1" Yes - Yes - 1p36.33 2824 GPM6B glycoprotein M6B Yes Yes - - Xp22.2 2885 GRB2 growth factor receptor-bound protein 2 Yes Yes - - 17q24-q25 2891 GRIA2 "glutamate receptor, ionotropic, AMPA 2" Yes Yes - - 4q32-q33 2897 GRIK1 "glutamate receptor, ionotropic, kainate 1" Yes - - - 21q22.11 2901 GRIK5 "glutamate receptor, ionotropic, kainate 5" Yes - - - 19q13.2 2902 GRIN1 "glutamate receptor, ionotropic, N-methyl D-aspartate 1" Yes - - - 9q34.3 2905 GRIN2C "glutamate receptor, ionotropic, N-methyl D-aspartate 2C" Yes Yes Yes - 17q25 2907 GRINA "glutamate receptor, ionotropic, N-methyl D-asparate-associated protein 1 (glutamate binding)" Yes Yes - - 8q24.3 2908 NR3C1 "nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)" Yes Yes Yes Yes 5q31.3 2915 GRM5 "glutamate receptor, metabotropic 5" Yes - - - 11q14.2-q14.3 2923 PDIA3 "protein disulfide isomerase family A, member 3" Yes Yes - - 15q15 2950 GSTP1 glutathione S-transferase pi - Yes - - 11q13 3091 HIF1A "hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)" Yes Yes Yes Yes 14q21-q24 3107 HLA-C "major histocompatibility complex, class I, C" Yes - - - 6p21.3 3122 HLA-DRA "major histocompatibility complex, class II, DR alpha" - Yes - - 6p21.3 3127 HLA-DRB5 "major histocompatibility complex, class II, DR beta 5" - - Yes - 6p21.3 3156 HMGCR 3-hydroxy-3-methylglutaryl-Coenzyme A reductase - Yes Yes - 5q13.3-q14 3162 HMOX1 heme oxygenase (decycling) 1 - Yes - - 22q12|22q13.1 3164 NR4A1 "nuclear receptor subfamily 4, group A, member 1" Yes Yes Yes Yes 12q13 3303 HSPA1A heat shock 70kDa protein 1A - - Yes - 6p21.3 3304 HSPA1B heat shock 70kDa protein 1B - - Yes - 6p21.3 3309 HSPA5 "heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)" Yes - Yes - 9q33-q34.1 3312 HSPA8 heat shock 70kDa protein 8 - Yes - - 11q24.1 3315 HSPB1 heat shock 27kDa protein 1 - - Yes - 7q11.23 3316 HSPB2 heat shock 27kDa protein 2 Yes Yes - - 11q22-q23 3337 DNAJB1 "DnaJ (Hsp40) homolog, subfamily B, member 1" - - Yes - 19p13.2 3351 HTR1B 5-hydroxytryptamine (serotonin) receptor 1B Yes Yes Yes - 6q13 3356 HTR2A 5-hydroxytryptamine (serotonin) receptor 2A - - - Yes 13q14-q21 3480 IGF1R insulin-like growth factor 1 receptor - Yes - - 15q26.3 3481 IGF2 insulin-like growth factor 2 (somatomedin A) Yes Yes - Yes 11p15.5 3485 IGFBP2 "insulin-like growth factor binding protein 2, 36kDa" Yes Yes - - 2q33-q34 3568 IL5RA "interleukin 5 receptor, alpha" - Yes - - 3p26-p24 3587 IL10RA "interleukin 10 receptor, alpha" Yes Yes - - 11q23 3604 TNFRSF9 "tumor necrosis factor receptor superfamily, member 9" - Yes - - 1p36 3707 ITPKB "inositol 1,4,5-trisphosphate 3-kinase B" Yes Yes - - 1q42.13 3725 JUN v-jun sarcoma virus 17 oncogene homolog (avian) Yes Yes - - 1p32-p31 3726 JUNB jun B proto-oncogene Yes - - - 19p13.2 3751 KCND2 "potassium voltage-gated channel, Shal-related subfamily, member 2" Yes Yes - - 7q31 3766 KCNJ10 "potassium inwardly-rectifying channel, subfamily J, member 10" Yes Yes - - 1q22-q23 3778 KCNMA1 "potassium large conductance calcium-activated channel, subfamily M, alpha member 1" - Yes - - 10q22.3 3916 LAMP1 lysosomal-associated membrane protein 1 Yes Yes Yes Yes 13q34 3921 RPSA ribosomal protein SA Yes Yes - - 3p22.2 3987 LIMS1 LIM and senescent cell antigen-like domains 1 - Yes - - 2q12.3-q13 4034 LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4 - Yes - - 7q22 4057 LTF lactotransferrin - Yes - - 3q21-q23 4069 LYZ lysozyme (renal amyloidosis) - Yes Yes - 12q15 4070 TACSTD2 tumor-associated calcium signal transducer 2 - Yes - - 1p32-p31 4099 MAG myelin associated glycoprotein - Yes - - 19q13.1 4118 MAL "mal, T-cell differentiation protein" - Yes - - 2cen-q13 4129 MAOB monoamine oxidase B - - - Yes Xp11.23 4131 MAP1B microtubule-associated protein 1B Yes - Yes - 5q13 4137 MAPT microtubule-associated protein tau Yes Yes - - 17q21.1 4155 MBP myelin basic protein Yes Yes Yes Yes 18q23 4191 MDH2 "malate dehydrogenase 2, NAD (mitochondrial)" - - Yes - 7p12.3-q11.2 4208 MEF2C "MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C)" - Yes - - 5q14 4299 AFF1 "AF4/FMR2 family, member 1" - Yes - - 4q21 4336 MOBP myelin-associated oligodendrocyte basic protein Yes Yes - - 3p22.1 4340 MOG myelin oligodendrocyte glycoprotein - Yes - - 6p22.1 4353 MPO myeloperoxidase - Yes - Yes 17q23.1 4359 MPZ myelin protein zero (Charcot-Marie-Tooth neuropathy 1B) - Yes - - 1q22 4485 MST1 macrophage stimulating 1 (hepatocyte growth factor-like) - Yes - - 3p21 4501 MT1X metallothionein 1X - Yes Yes - 16q13 4502 MT2A metallothionein 2A - Yes - - 16q13 5742 PTGS1 cytochrome c oxidase subunit I Yes - - - - 4719 NDUFS1 "NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)" Yes Yes - - 2q33-q34 4729 NDUFV2 "NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa" Yes - Yes - 18p11.31-p11.2 4741 NEF3 neurofilament 3 (150kDa medium) Yes Yes - - 8p21 4744 NEFH "neurofilament, heavy polypeptide 200kDa" Yes Yes - - 22q12.2 4747 NEFL "neurofilament, light polypeptide 68kDa" Yes - Yes - 8p21 4753 NELL2 NEL-like 2 (chicken) - Yes - - 12q13.11-q13.12 4763 NF1 "neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)" Yes - Yes - 17q11.2 4774 NFIA nuclear factor I/A Yes Yes Yes - 1p31.3-p31.2 4781 NFIB nuclear factor I/B Yes Yes Yes Yes 9p24.1 4792 NFKBIA "nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha" - Yes Yes - 14q13 4821 NKX2-2 "NK2 transcription factor related, locus 2 (Drosophila)" - Yes - - 20pter-q11.23 4852 NPY neuropeptide Y Yes Yes - - 7p15.1 4884 NPTX1 neuronal pentraxin I Yes Yes - - 17q25.1-q25.2 4900 NRGN "neurogranin (protein kinase C substrate, RC3)" Yes Yes - - 11q24 4905 NSF N-ethylmaleimide-sensitive factor Yes Yes Yes - 17q21 4915 NTRK2 "neurotrophic tyrosine kinase, receptor, type 2" Yes Yes Yes - 9q22.1 4985 OPRD1 "opioid receptor, delta 1" - - Yes - 1p36.1-p34.3 4986 OPRK1 "opioid receptor, kappa 1" Yes - Yes - 8q11.2 4988 OPRM1 "opioid receptor, mu 1" - - Yes - 6q24-q25 5066 PAM peptidylglycine alpha-amidating monooxygenase - Yes - - 5q14-q21 5091 PC pyruvate carboxylase - Yes - - 11q13.4-q13.5 5121 PCP4 Purkinje cell protein 4 Yes Yes Yes Yes 21q22.2 5126 PCSK2 proprotein convertase subtilisin/kexin type 2 Yes Yes Yes Yes 20p11.2 5166 PDK4 "pyruvate dehydrogenase kinase, isozyme 4" - Yes - - 7q21.3 5168 ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) - Yes - - 8q24.1 5173 PDYN prodynorphin Yes Yes Yes - 20pter-p12 5179 PENK proenkephalin Yes Yes Yes Yes 8q23-q24 5187 PER1 period homolog 1 (Drosophila) Yes - - - 17p13.1-17p12 5315 PKM2 "pyruvate kinase, muscle" Yes - Yes - 15q22 5319 PLA2G1B "phospholipase A2, group IB (pancreas)" - Yes - - 12q23-q24.1 5354 PLP1 "proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)" Yes Yes - - Xq22 5376 PMP22 peripheral myelin protein 22 - Yes - - 17p12-p11.2 5414 SEPT4 septin 4 Yes - - Yes 17q22-q23 5495 PPM1B "protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform" - Yes - - 2p21 5504 PPP1R2 "protein phosphatase 1, regulatory (inhibitor) subunit 2" - Yes - - 3q29 5516 PPP2CB "protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform" Yes Yes - - 8p12 5527 PPP2R5C "protein phosphatase 2, regulatory subunit B (B56), gamma isoform" - Yes - - 14q32 5573 PRKAR1A "protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)" - Yes - - 17q23-q24 5575 PRKAR1B "protein kinase, cAMP-dependent, regulatory, type I, beta" - Yes - - 7p22 5578 PRKCA "protein kinase C, alpha" Yes - - - 17q22-q23.2 5581 PRKCE "protein kinase C, epsilon" Yes - - - 2p21 5582 PRKCG "protein kinase C, gamma" Yes - Yes - 19q13.4 5590 PRKCZ "protein kinase C, zeta" Yes Yes - - 1p36.33-p36.2 5594 MAPK1 mitogen-activated protein kinase 1 Yes Yes - - 22q11.2|22q11.21 5595 MAPK3 mitogen-activated protein kinase 3 Yes - - - 16p11.2 5601 MAPK9 mitogen-activated protein kinase 9 - Yes Yes - 5q35 5602 MAPK10 mitogen-activated protein kinase 10 Yes Yes Yes Yes 4q22.1-q23 5604 MAP2K1 mitogen-activated protein kinase kinase 1 Yes Yes - - 15q22.1-q22.33 5654 HTRA1 HtrA serine peptidase 1 - Yes - - 10q26.3 5692 PSMB4 "proteasome (prosome, macropain) subunit, beta type, 4" - - Yes - 1q21 5747 PTK2 PTK2 protein tyrosine kinase 2 Yes Yes - - 8q24-qter 5813 PURA purine-rich element binding protein A - Yes - - 5q31 5860 QDPR quinoid dihydropteridine reductase Yes Yes Yes Yes 4p15.31 5870 RAB6A "RAB6A, member RAS oncogene family" - Yes - Yes 11q13.3 5887 RAD23B RAD23 homolog B (S. cerevisiae) - Yes - - 9q31.2 5901 RAN "RAN, member RAS oncogene family" - Yes - - 12q24.3 5925 RB1 retinoblastoma 1 (including osteosarcoma) - Yes - - 13q14.2 5977 DPF2 "D4, zinc and double PHD fingers family 2" - Yes - - 11q13 5999 RGS4 regulator of G-protein signalling 4 Yes Yes Yes Yes 1q23.3 6122 RPL3 ribosomal protein L3 - Yes - - 22q13 6147 RPL23A ribosomal protein L23a Yes - - - 17q11 6156 RPL30 ribosomal protein L30 - Yes - - 8q22 6199 RPS6KB2 "ribosomal protein S6 kinase, 70kDa, polypeptide 2" - Yes - - 11q13.1 6252 RTN1 reticulon 1 - Yes - - 14q23.1 6310 ATXN1 ataxin 1 - Yes - - 6p23 6327 SCN2B "sodium channel, voltage-gated, type II, beta" Yes Yes - - 11q23 6376 CX3CL1 chemokine (C-X3-C motif) ligand 1 Yes Yes - - 16q13 6383 SDC2 "syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan)" - Yes - - 8q22-q23 6387 CXCL12 chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) - Yes - - 10q11.1 6421 SFPQ splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated) Yes Yes Yes Yes 1p34.3 6431 SFRS6 "splicing factor, arginine/serine-rich 6" - Yes - - 20q12-q13.1 6432 SFRS7 "splicing factor, arginine/serine-rich 7, 35kDa" - Yes - - 2p22.1 6446 SGK serum/glucocorticoid regulated kinase - Yes Yes - 6q23 6513 SLC2A1 "solute carrier family 2 (facilitated glucose transporter), member 1" - Yes - - 1p35-p31.3 6520 SLC3A2 "solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2" - Yes - - 11q13 6529 SLC6A1 "solute carrier family 6 (neurotransmitter transporter, GABA), member 1" - Yes Yes - 3p25-p24 6530 SLC6A2 "solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2" - Yes - - 16q12.2 6531 SLC6A3 "solute carrier family 6 (neurotransmitter transporter, dopamine), member 3" - - - Yes 5p15.3 6532 SLC6A4 "solute carrier family 6 (neurotransmitter transporter, serotonin), member 4" Yes Yes Yes Yes 17q11.1-q12 6602 SMARCD1 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1" - Yes - - 12q13-q14 6606 SMN1 "survival of motor neuron 1, telomeric" Yes Yes Yes Yes 5q13 6610 SMPD2 "sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)" - Yes - - 6q21 6620 SNCB "synuclein, beta" - Yes - - 5q35 6622 SNCA "synuclein, alpha (non A4 component of amyloid precursor)" - Yes - - 4q21 6624 FSCN1 "fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)" - Yes - - 7p22 6648 SOD2 "superoxide dismutase 2, mitochondrial" - Yes - - 6q25.3 6657 SOX2 SRY (sex determining region Y)-box 2 - Yes - - 3q26.3-q27 6662 SOX9 "SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)" - Yes - - 17q24.3-q25.1 6663 SOX10 SRY (sex determining region Y)-box 10 - Yes - - 22q13.1 6678 SPARC "secreted protein, acidic, cysteine-rich (osteonectin)" Yes Yes - - 5q31.3-q32 6712 SPTBN2 "spectrin, beta, non-erythrocytic 2" - Yes - - 11q13 6804 STX1A syntaxin 1A (brain) - Yes - - 7q11.23 6813 STXBP2 syntaxin binding protein 2 - Yes - - 19p13.3-p13.2 6853 SYN1 synapsin I - - Yes - Xp11.23 6854 SYN2 synapsin II - Yes - - 3p25 6863 TAC1 "tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)" Yes Yes Yes - 7q21-q22 6869 TACR1 tachykinin receptor 1 - - Yes - 2p13.1 7001 PRDX2 peroxiredoxin 2 - Yes - - 19p13.2 7018 TF transferrin - Yes - - 3q22.1 7021 TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) - Yes - - 6p21-p12 7025 NR2F1 "nuclear receptor subfamily 2, group F, member 1" - Yes - - 5q14 7037 TFRC "transferrin receptor (p90, CD71)" Yes Yes - - 3q29 7054 TH tyrosine hydroxylase Yes Yes - Yes 11p15.5 7068 THRB "thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)" - Yes - - 3p24.2 7070 THY1 Thy-1 cell surface antigen Yes Yes - - 11q22.3-q23 7071 KLF10 Kruppel-like factor 10 - Yes Yes - 8q22.2 7076 TIMP1 TIMP metallopeptidase inhibitor 1 - Yes - - Xp11.3-p11.23 7080 TITF1 thyroid transcription factor 1 - Yes - - 14q13 7086 TKT transketolase (Wernicke-Korsakoff syndrome) Yes Yes Yes Yes 3p14.3 7122 CLDN5 claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) - Yes - - 22q11.21 7124 TNF "tumor necrosis factor (TNF superfamily, member 2)" - - - Yes 6p21.3 7167 TPI1 triosephosphate isomerase 1 Yes - Yes - 12p13 7277 TUBA1 "tubulin, alpha 1 (testis specific)" Yes Yes - - 2q35 7287 TULP1 tubby like protein 1 - Yes - - 6p21.3 7336 UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 Yes Yes - - 8q11.21 7345 UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) Yes Yes Yes - 4p14 7384 UQCRC1 ubiquinol-cytochrome c reductase core protein I Yes Yes - - 3p21.3 7385 UQCRC2 ubiquinol-cytochrome c reductase core protein II - Yes - - 16p12 7416 VDAC1 voltage-dependent anion channel 1 Yes Yes - - 5q31 7447 VSNL1 visinin-like 1 - Yes - - 2p24.3 7514 XPO1 "exportin 1 (CRM1 homolog, yeast)" - Yes - - 2p16 7529 YWHAB "tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide" - Yes - Yes 20q13.1 7532 YWHAG "tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide" - Yes Yes - 7q11.23 7533 YWHAH "tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide" Yes Yes - - 22q12.3 7704 ZBTB16 zinc finger and BTB domain containing 16 - Yes - - 11q23.1 7846 TUBA3 "tubulin, alpha 3" Yes Yes - - 12q12-12q14.3 7852 CXCR4 chemokine (C-X-C motif) receptor 4 Yes Yes - - 2q21 7857 SCG2 secretogranin II (chromogranin C) - Yes - - 2q35-q36 8013 NR4A3 "nuclear receptor subfamily 4, group A, member 3" Yes - Yes - 9q22 8100 IFT88 intraflagellar transport 88 homolog (Chlamydomonas) - Yes - - 13q12.1 8288 EPX eosinophil peroxidase - Yes - Yes 17q23.1 8326 FZD9 frizzled homolog 9 (Drosophila) - Yes - - 7q11.23 8439 NSMAF neutral sphingomyelinase (N-SMase) activation associated factor - Yes - - 8q12-q13 8775 NAPA "N-ethylmaleimide-sensitive factor attachment protein, alpha" - - Yes - 19q13.32 8777 MPDZ multiple PDZ domain protein - Yes - - 9p24-p22 8787 RGS9 regulator of G-protein signalling 9 - Yes - - 17q23-q24 8829 NRP1 neuropilin 1 - Yes - - 10p12 8864 PER2 period homolog 2 (Drosophila) Yes - Yes - 2q37.3 8993 PGLYRP1 peptidoglycan recognition protein 1 - Yes - - 19q13.2-q13.3 8997 KALRN "kalirin, RhoGEF kinase" - Yes - - 3q21.1-q21.2 9040 UBE2M "ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)" Yes Yes Yes Yes 19q13.43 9146 HGS hepatocyte growth factor-regulated tyrosine kinase substrate Yes Yes - - 17q25 9230 RAB11B "RAB11B, member RAS oncogene family" - Yes - - 19p13.2 9241 NOG noggin - - Yes - 17q21-q22 9252 RPS6KA5 "ribosomal protein S6 kinase, 90kDa, polypeptide 5" Yes Yes - - 14q31-q32.1 9322 TRIP10 thyroid hormone receptor interactor 10 - Yes - - 19p13.3 9341 VAMP3 vesicle-associated membrane protein 3 (cellubrevin) - Yes - - 1p36.23 9452 ITM2A integral membrane protein 2A - Yes - - Xq13.3-Xq21.2 9455 HOMER2 homer homolog 2 (Drosophila) Yes - - - 15q24.3 9527 GOSR1 golgi SNAP receptor complex member 1 - Yes - - 17q11 9568 GABBR2 "gamma-aminobutyric acid (GABA) B receptor, 2" - - - Yes 9q22.1-q22.3 9575 CLOCK clock homolog (mouse) Yes - - - 4q12 9588 PRDX6 peroxiredoxin 6 - Yes Yes - 1q25.1 9607 CART cocaine- and amphetamine-regulated transcript Yes - - - 5q13.2 9615 GDA guanine deaminase - - Yes - 9q21.13 9868 TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) - Yes - - 3q12.2 10076 PTPRU "protein tyrosine phosphatase, receptor type, U" - Yes - - 1p35.3-p35.1 10276 NET1 neuroepithelial cell transforming gene 1 - Yes - - 10p15 10379 ISGF3G "interferon-stimulated transcription factor 3, gamma 48kDa" Yes - - - 14q11.2 10399 GNB2L1 "guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1" Yes Yes Yes Yes 5q35.3 10439 OLFM1 olfactomedin 1 Yes Yes Yes Yes 9q34.3 10486 CAP2 "CAP, adenylate cyclase-associated protein, 2 (yeast)" - Yes - - 6p22.3 10628 TXNIP thioredoxin interacting protein - Yes - - 1q21.1 10681 GNB5 "guanine nucleotide binding protein (G protein), beta 5" Yes Yes Yes - 15q21.2 10772 FUSIP1 FUS interacting protein (serine/arginine-rich) 1 - Yes - - 1p36.11 10844 TUBGCP2 "tubulin, gamma complex associated protein 2" - Yes - - 10q26.3 10912 GADD45G "growth arrest and DNA-damage-inducible, gamma" - Yes - Yes 9q22.1-q22.2 10924 SMPDL3A "sphingomyelin phosphodiesterase, acid-like 3A" - Yes - - 6q22.31 10950 BTG3 "BTG family, member 3" - Yes - - 21q21.1-q21.2 10972 TMED10 transmembrane emp24-like trafficking protein 10 (yeast) - Yes - - 14q24.3 11031 RAB31 "RAB31, member RAS oncogene family" - Yes - - 18p11.3 11075 STMN2 stathmin-like 2 - Yes - - 8q21.13 11163 NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 - Yes - - 12q21 11170 FAM107A "family with sequence similarity 107, member A" - Yes - - 3p21.1 22924 MAPRE3 "microtubule-associated protein, RP/EB family, member 3" - Yes - - 2p23.3-p23.1 23208 SYT11 synaptotagmin XI Yes Yes - - 1q21.2 23236 PLCB1 "phospholipase C, beta 1 (phosphoinositide-specific)" - Yes - Yes 20p12 23237 ARC activity-regulated cytoskeleton-associated protein Yes - Yes Yes 8q24.3 23336 DMN desmuslin - Yes - - 15q26.3 23451 SF3B1 "splicing factor 3b, subunit 1, 155kDa" - Yes - - 2q33.1 23467 NPTXR neuronal pentraxin receptor Yes Yes - - 22q13.1 23678 SGK3 "serum/glucocorticoid regulated kinase family, member 3" - Yes - - 8q12.3-8q13.1 25932 CLIC4 chloride intracellular channel 4 - Yes - - 1p36.11 25946 ZNF385 zinc finger protein 385 - Yes - - 12q13.13 27075 TSPAN13 tetraspanin 13 Yes Yes Yes Yes 7p21.1 27086 FOXP1 forkhead box P1 - Yes - - 3p14.1 27244 SESN1 sestrin 1 - Yes - - 6q21 28951 TRIB2 tribbles homolog 2 (Drosophila) - Yes - - 2p25.1-p24.3 28999 KLF15 Kruppel-like factor 15 - Yes - - 3q13-q21 29114 TAGLN3 transgelin 3 Yes Yes - - 3q13.2 29760 BLNK B-cell linker - Yes - - 10q23.2-q23.33 29767 TMOD2 tropomodulin 2 (neuronal) Yes Yes Yes - 15q21.1-q21.2 29896 TRA2A transformer-2 alpha - Yes - - 7p15.3 29970 SCHIP1 schwannomin interacting protein 1 - Yes - - 3q25.33 54206 ERRFI1 ERBB receptor feedback inhibitor 1 - Yes - - 1p36.12-36.33 54541 DDIT4 DNA-damage-inducible transcript 4 - Yes - - 10pter-q26.12 54704 PPM2C "protein phosphatase 2C, magnesium-dependent, catalytic subunit" Yes Yes Yes Yes 8q22.1 54838 C10orf26 chromosome 10 open reading frame 26 - Yes - - 10q24.32 54941 RNF125 ring finger protein 125 - Yes - - 18q12.1 55319 TMA16 translation machinery associated 16 homolog (S. cerevisiae)/hypothetical protein FLJ11184 - Yes - - 4q32.3 55885 LMO3 LIM domain only 3 (rhombotin-like 2) Yes Yes Yes - 12p12.3 56253 CRTAM class-I MHC-restricted T cell associated molecule - Yes - - 11q22-q23 58476 TP53INP2 tumor protein p53 inducible nuclear protein 2 Yes Yes - - 20q11.22 58480 RHOU "ras homolog gene family, member U" - Yes - - 1q42.11-q42.3 79830 ZMYM1 "zinc finger, MYM-type 1" Yes Yes Yes Yes 1p34.3 80176 SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 - Yes - - 1p36.22 94241 TP53INP1 tumor protein p53 inducible nuclear protein 1 - Yes - - 8q22 112939 BTBD14B BTB (POZ) domain containing 14B Yes - - - 19p13.13 113791 PIK3IP1 phosphoinositide-3-kinase interacting protein 1 - Yes - - 22q12.2 114823 LENG8 leukocyte receptor cluster (LRC) member 8 - Yes - - 19q13.42 114876 OSBPL1A oxysterol binding protein-like 1A Yes Yes Yes Yes 18q11.1 286827 TRIM59 tripartite motif-containing 59 - Yes - - 3q26.1 347733 TUBB2B "tubulin, beta 2B" - - Yes - 6p25 359845 FAM101B "family with sequence similarity 101, member B" - Yes - - 17p13 388524 RPSAP58 similar to Laminin receptor 1 Yes - - - 19p12