File Name : fig. s1a-b final.tif

Caption : figure s1 representative h&e staining of (a) one half of a hse replicate (16-day airlift culture under normal conditions) used for histology and (b) the other half following full spectroscopic characterisation. scale bars: 100 μm.

File Name : figure s2a-b.tif

Caption : water mass percentage profiles obtained from hse 16+il4-treated #1 at two locations: (a) the first location at which spectra were acquired, termed location a, and (b) the fourth one, termed location d. measurement points p1, p2, etc., are used to define the lines (black) whose intersections yield the depths at which the stratum corneum, the viable epidermis and the dermal matrix intersect. these intersection depths are subsequently used to estimate the thicknesses of the stratum corneum and the viable epidermis.

File Name : fig. s3a-f.tif

Caption : figure s3 raman spectroscopic data of human forearm skin and the skin equivalent epidermfttm. (a, b) water mass percentage profiles, (c, d) ceramide intensity and (e, f) cholesterol intensity profiles.