==> chlorpromazine_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 2.4032528115929394e-11 2.006247639650596e-12 6.943716786233445e-12 11.97884430663547 -6.0 -10.61920054092951 -11.697615461198005 -11.158408001063757 5e-06 1.20162640579647e-10 1.0031238198252979e-11 3.471858393116722e-11 11.978844306635475 -5.301029995663981 -9.920230536593492 -10.998645456861986 -10.459437996727738 1e-05 2.40325281159294e-10 2.0062476396505958e-11 6.943716786233445e-11 11.978844306635475 -5.0 -9.61920054092951 -10.697615461198005 -10.158408001063757 5e-05 1.20162640579647e-09 1.0031238198252981e-10 3.4718583931167147e-10 11.978844306635473 -4.301029995663981 -8.920230536593492 -9.998645456861986 -9.45943799672774 0.0001 2.40325281159294e-09 2.0062476396505962e-10 6.94371678623343e-10 11.978844306635473 -4.0 -8.61920054092951 -9.697615461198005 -9.158408001063759 0.001 2.4032528115929392e-08 2.006247639650596e-09 6.94371678623343e-09 11.97884430663547 -3.0 -7.61920054092951 -8.697615461198005 -8.158408001063759 0.01 2.4032528115929393e-07 2.0062476396505957e-08 6.94371678623343e-08 11.978844306635473 -2.0 -6.61920054092951 -7.697615461198006 -7.1584080010637585 0.1 2.40325281159294e-06 2.006247639650596e-07 6.94371678623343e-07 11.978844306635473 -1.0 -5.61920054092951 -6.697615461198006 -6.1584080010637585 1.0 2.4032528115929392e-05 2.0062476396505955e-06 6.943716786233431e-06 11.978844306635473 0.0 -4.61920054092951 -5.697615461198006 -5.1584080010637585 10.0 0.0002403252811592939 2.0062476396505963e-05 6.94371678623343e-05 11.978844306635468 1.0 -3.6192005409295107 -4.697615461198006 -4.1584080010637585 25.0 0.0006008132028982348 5.01561909912649e-05 0.0001735929196558358 11.97884430663547 1.3979400086720377 -3.2212605322574728 -4.299675452525968 -3.7604679923917206 50.0 0.0012016264057964697 0.0001003123819825298 0.00034718583931167167 11.97884430663547 1.6989700043360187 -2.9202305365934915 -3.9986454568619867 -3.4594379967277393 75.0 0.0022186909270042023 0.00030098760848039135 0.0008171893758952925 7.371369666033095 1.8750612633917 -2.653903192605963 -3.521451383739596 -3.087677288172779 100.0 0.0022759637717968237 0.0003520601305882885 0.0008951402698532805 6.464701833728556 2.0 -2.642834655209282 -3.45338315427062 -3.048108904739951 250.0 0.003180368637147001 0.0006641055220152445 0.0014533067033401523 4.788950749116036 2.3979400086720375 -2.497522537940106 -3.1777629086020243 -2.837642723271065 500.0 0.004370191089669599 0.0012061917813460878 0.002295928695598226 3.623131211184797 2.6989700043360187 -2.359499572783663 -2.918583635016287 -2.639041603899975 1000.0 0.006888138441110762 0.002378202088219741 0.004047392398149243 2.8963638015586137 3.0 -2.1618981328078473 -2.623751243884852 -2.3928246883463498 2500.0 0.009784580977265636 0.003988720001078846 0.006247235696385646 2.453062880979151 3.3979400086720375 -2.009457768182565 -2.3991664490886024 -2.204312108635584 5000.0 0.009784580977265636 0.003988720001078846 0.006247235696385646 2.453062880979151 3.6989700043360187 -2.009457768182565 -2.3991664490886024 -2.204312108635584 10000.0 0.009784580977265636 0.003988720001078846 0.006247235696385646 2.453062880979151 4.0 -2.009457768182565 -2.3991664490886024 -2.204312108635584 ==> chlorpromazine_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 8.472177109797215e-12 1.989740542727131e-12 4.105780593325507e-12 4.257930583343937 -6.0 -11.072004973934137 -11.701203550830611 -11.386604262382372 5e-06 4.236088554898608e-11 9.948702713635658e-12 2.0528902966627533e-11 4.257930583343937 -5.301029995663981 -10.373034969598118 -11.002233546494592 -10.687634258046353 1e-05 8.472177109797216e-11 1.9897405427271316e-11 4.105780593325507e-11 4.257930583343937 -5.0 -10.072004973934137 -10.701203550830611 -10.386604262382372 5e-05 4.2360885548986077e-10 9.948702713635657e-11 2.0528902966627534e-10 4.257930583343937 -4.301029995663981 -9.373034969598118 -10.002233546494592 -9.687634258046353 0.0001 8.472177109797215e-10 1.9897405427271314e-10 4.1057805933254986e-10 4.257930583343937 -4.0 -9.072004973934137 -9.701203550830611 -9.386604262382374 0.001 8.472177109797215e-09 1.989740542727131e-09 4.105780593325499e-09 4.257930583343937 -3.0 -8.072004973934137 -8.701203550830611 -8.386604262382374 0.01 8.472177109797216e-08 1.9897405427271314e-08 4.105780593325499e-08 4.257930583343937 -2.0 -7.072004973934137 -7.70120355083061 -7.386604262382374 0.1 8.472177109797216e-07 1.989740542727131e-07 4.1057805933254986e-07 4.257930583343938 -1.0 -6.072004973934137 -6.70120355083061 -6.386604262382374 1.0 8.472177109797215e-06 1.9897405427271313e-06 4.1057805933254995e-06 4.257930583343937 0.0 -5.072004973934137 -5.70120355083061 -5.386604262382374 10.0 8.472177109797214e-05 1.989740542727131e-05 4.105780593325499e-05 4.257930583343937 1.0 -4.072004973934137 -4.70120355083061 -4.386604262382374 25.0 0.00021180442774493038 4.9743513568178274e-05 0.00010264451483313744 4.257930583343938 1.3979400086720377 -3.6740649652620987 -4.3032635421585725 -3.988664253710336 50.0 0.00042360885548986077 9.948702713635655e-05 0.0002052890296662749 4.257930583343938 1.6989700043360187 -3.3730349695981174 -4.002233546494591 -3.6876342580463546 75.0 0.0012689805943841956 0.00029851118309795753 0.0006154712816679391 4.251032008967567 1.8750612633917 -2.8965450192104973 -3.525039394294216 -3.2107922067523567 100.0 0.0014766499262874949 0.00034916353308737333 0.000718047564856083 4.229106955215691 2.0 -2.8307224519472767 -3.456971120653556 -3.1438467863004163 250.0 0.0026403657469813383 0.0006586420878790519 0.0013187327281735752 4.008802042219621 2.3979400086720375 -2.578335909912834 -3.181350520891638 -2.879843215402236 500.0 0.004308053466957443 0.0011962712549696082 0.002270154295944078 3.6012346272308378 2.6989700043360187 -2.365718915341445 -2.922170332739441 -2.6439446240404427 1000.0 0.007016335710736481 0.0023586637507385295 0.004068067932560418 2.974707907619122 3.0 -2.1538896394492664 -2.627333967383736 -2.390611803416501 2500.0 0.009844197615221978 0.003956089417228669 0.006240554943808071 2.48836580193328 3.3979400086720375 -2.0068196767308137 -2.402733900853895 -2.2047767887923544 5000.0 0.009844197615221978 0.003956089417228669 0.006240554943808071 2.48836580193328 3.6989700043360187 -2.0068196767308137 -2.402733900853895 -2.2047767887923544 10000.0 0.009844197615221978 0.003956089417228669 0.006240554943808071 2.48836580193328 4.0 -2.0068196767308137 -2.402733900853895 -2.2047767887923544 ==> chlorpromazine_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 8.507257409984084e-11 1.4283515643616356e-12 1.1023318207317567e-11 59.5599684436666 -6.0 -10.070210426247128 -11.845164885227451 -10.957687655737288 5e-06 4.253628704992042e-10 7.141757821808178e-12 5.511659103658783e-11 59.5599684436666 -5.301029995663981 -9.371240421911109 -11.14619488089143 -10.25871765140127 1e-05 8.507257409984084e-10 1.4283515643616356e-11 1.1023318207317567e-10 59.5599684436666 -5.0 -9.070210426247128 -10.845164885227451 -9.957687655737288 5e-05 4.253628704992043e-09 7.14175782180818e-11 5.511659103658783e-10 59.5599684436666 -4.301029995663981 -8.371240421911109 -10.14619488089143 -9.25871765140127 0.0001 8.507257409984086e-09 1.428351564361636e-10 1.1023318207317567e-09 59.5599684436666 -4.0 -8.070210426247128 -9.84516488522745 -8.957687655737288 0.001 8.507257409984083e-08 1.4283515643616357e-09 1.1023318207317567e-08 59.55996844366659 -3.0 -7.070210426247129 -8.84516488522745 -7.957687655737289 0.01 8.507257409984085e-07 1.4283515643616359e-08 1.1023318207317567e-07 59.5599684436666 -2.0 -6.070210426247129 -7.84516488522745 -6.957687655737289 0.1 8.507257409984085e-06 1.4283515643616358e-07 1.1023318207317567e-06 59.5599684436666 -1.0 -5.070210426247129 -6.84516488522745 -5.957687655737289 1.0 8.507257409984083e-05 1.4283515643616356e-06 1.1023318207317556e-05 59.55996844366659 0.0 -4.070210426247129 -5.84516488522745 -4.957687655737289 10.0 0.0008507257409984083 1.428351564361636e-05 0.00011023318207317555 59.559968443666584 1.0 -3.0702104262471286 -4.84516488522745 -3.9576876557372893 25.0 0.0021268143524960214 3.570878910904089e-05 0.0002755829551829391 59.55996844366661 1.3979400086720377 -2.6722704175750907 -4.4472248765554125 -3.5597476470652514 50.0 0.004253628704992043 7.141757821808178e-05 0.000551165910365878 59.55996844366661 1.6989700043360187 -2.3712404219111094 -4.146194880891431 -3.2587176514012706 75.0 0.00987274758011397 0.00021391162799172677 0.001453236218793614 46.15339368318868 1.8750612633917 -2.005561966598343 -3.669765607034902 -2.837663786816622 100.0 0.009908641005564506 0.00024997775603906997 0.0015738296743827553 39.63809085483529 2.0 -2.0039859059845906 -3.6020986347651043 -2.8030422703748474 250.0 0.010419629931194626 0.0004685425189947503 0.002209533809416599 22.23838714477772 2.3979400086720375 -1.9821477053833418 -3.3292509919119317 -2.655699348647637 500.0 0.010988341327258882 0.0008412106484658771 0.0030403140846741224 13.062532372002675 2.6989700043360187 -1.959067858694257 -3.0750952384337658 -2.5170815485640112 1000.0 0.012177862700148737 0.0016191068934816016 0.004440412305820631 7.521345717923792 3.0 -1.9144289267262253 -2.7907244781664873 -2.352576702446356 2500.0 0.013594996742167163 0.0026344047224603037 0.005984540384975075 5.160557383707779 3.3979400086720375 -1.8666208921484924 -2.579317503774811 -2.2229691979616515 5000.0 0.013594996742167163 0.0026344047224603037 0.005984540384975075 5.160557383707779 3.6989700043360187 -1.8666208921484924 -2.579317503774811 -2.2229691979616515 10000.0 0.013594996742167163 0.0026344047224603037 0.005984540384975075 5.160557383707779 4.0 -1.8666208921484924 -2.579317503774811 -2.2229691979616515 ==> chlorpromazine_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 8.924954277223823e-12 1.4194203486261504e-12 3.559250161431416e-12 6.287745758937612 -6.0 -11.049394000112157 -11.847888973073099 -11.448641486592626 5e-06 4.4624771386119126e-11 7.097101743130751e-12 1.7796250807157077e-11 6.287745758937613 -5.301029995663981 -10.350423995776138 -11.14891896873708 -10.749671482256607 1e-05 8.924954277223825e-11 1.4194203486261502e-11 3.559250161431416e-11 6.287745758937613 -5.0 -10.049394000112157 -10.847888973073099 -10.448641486592626 5e-05 4.462477138611913e-10 7.097101743130751e-11 1.7796250807157004e-10 6.287745758937614 -4.301029995663981 -9.350423995776138 -10.14891896873708 -9.749671482256609 0.0001 8.924954277223826e-10 1.4194203486261501e-10 3.5592501614314014e-10 6.287745758937614 -4.0 -9.049394000112157 -9.847888973073099 -9.448641486592628 0.001 8.924954277223824e-09 1.4194203486261504e-09 3.5592501614314017e-09 6.2877457589376125 -3.0 -8.049394000112157 -8.847888973073099 -8.448641486592628 0.01 8.924954277223826e-08 1.4194203486261504e-08 3.5592501614314016e-08 6.287745758937613 -2.0 -7.049394000112156 -7.8478889730731 -7.448641486592629 0.1 8.924954277223825e-07 1.4194203486261508e-07 3.5592501614314016e-07 6.287745758937611 -1.0 -6.049394000112156 -6.847888973073099 -6.448641486592629 1.0 8.924954277223824e-06 1.4194203486261505e-06 3.559250161431409e-06 6.287745758937612 0.0 -5.049394000112156 -5.8478889730731 -5.448641486592628 10.0 8.924954277223822e-05 1.4194203486261502e-05 3.559250161431405e-05 6.287745758937612 1.0 -4.049394000112156 -4.8478889730731 -4.448641486592628 25.0 0.0002231238569305956 3.548550871565376e-05 8.89812540357852e-05 6.287745758937612 1.3979400086720377 -3.6514539914401185 -4.449948964401061 -4.05070147792059 50.0 0.0004462477138611912 7.097101743130752e-05 0.00017796250807157024 6.287745758937612 1.6989700043360187 -3.3504239957761377 -4.148918968737081 -3.749671482256609 75.0 0.0013219205679105032 0.00021302392420538435 0.0005306606324800303 6.20550284594321 1.8750612633917 -2.8787946401261473 -3.6715716192518064 -3.2751831296889766 100.0 0.0015403080135354182 0.0002492197565485681 0.0006195766200746324 6.180521299222287 2.0 -2.812392425135536 -3.6034175325589133 -3.2079049788472247 250.0 0.002808397649510682 0.000470850941159878 0.001149928987556751 5.964515314746047 2.3979400086720375 -2.5515413991201172 -3.3271165571543686 -2.939328978137243 500.0 0.004779655419930613 0.0008583809471269794 0.0020255283622553004 5.568221703811377 2.6989700043360187 -2.320603411885144 -3.066319930661687 -2.6934616712734156 1000.0 0.008056329502806062 0.0017122447724114097 0.0037140824002710932 4.705127229829455 3.0 -2.093862779504588 -2.766434151043802 -2.430148465274195 2500.0 0.011317172344708366 0.0029381289762873413 0.005766395060661852 3.851829663042531 3.3979400086720375 -1.9462620703644111 -2.531929143719199 -2.239095607041805 5000.0 0.011317172344708366 0.0029381289762873413 0.005766395060661852 3.851829663042531 3.6989700043360187 -1.9462620703644111 -2.531929143719199 -2.239095607041805 10000.0 0.011317172344708366 0.0029381289762873413 0.005766395060661852 3.851829663042531 4.0 -1.9462620703644111 -2.531929143719199 -2.239095607041805 ==> chlorpromazine_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.394657595224881e-11 1.6185695888772947e-12 4.751158143576936e-12 8.616605704251937 -6.0 -10.855532403685915 -11.790868623777184 -11.323200513731548 5e-06 6.973287976124406e-11 8.092847944386475e-12 2.3755790717884676e-11 8.616605704251937 -5.301029995663981 -10.156562399349896 -11.091898619441166 -10.62423050939553 1e-05 1.3946575952248812e-10 1.618569588877295e-11 4.751158143576936e-11 8.616605704251937 -5.0 -9.855532403685915 -10.790868623777184 -10.323200513731548 5e-05 6.973287976124405e-10 8.092847944386476e-11 2.375579071788463e-10 8.616605704251935 -4.301029995663981 -9.156562399349896 -10.091898619441166 -9.624230509395531 0.0001 1.394657595224881e-09 1.6185695888772952e-10 4.751158143576916e-10 8.616605704251935 -4.0 -8.855532403685915 -9.790868623777184 -9.32320051373155 0.001 1.394657595224881e-08 1.6185695888772952e-09 4.751158143576917e-09 8.616605704251935 -3.0 -7.855532403685915 -8.790868623777184 -8.32320051373155 0.01 1.394657595224881e-07 1.618569588877295e-08 4.751158143576917e-08 8.616605704251937 -2.0 -6.855532403685915 -7.790868623777183 -7.323200513731551 0.1 1.394657595224881e-06 1.6185695888772957e-07 4.751158143576926e-07 8.616605704251933 -1.0 -5.855532403685915 -6.790868623777183 -6.32320051373155 1.0 1.3946575952248811e-05 1.6185695888772952e-06 4.751158143576927e-06 8.616605704251935 0.0 -4.855532403685915 -5.790868623777183 -5.32320051373155 10.0 0.00013946575952248808 1.618569588877295e-05 4.751158143576926e-05 8.616605704251933 1.0 -3.855532403685915 -4.790868623777183 -4.32320051373155 25.0 0.00034866439880622025 4.046423972193237e-05 0.00011877895358942313 8.616605704251937 1.3979400086720377 -3.4575923950138776 -4.392928615105146 -3.9252605050595117 50.0 0.0006973287976124405 8.092847944386474e-05 0.00023755790717884615 8.616605704251937 1.6989700043360187 -3.1565623993498964 -4.091898619441165 -3.624230509395531 75.0 0.00209990321289973 0.000242552683485445 0.0007136786106844852 8.657513834621172 1.8750612633917 -2.6778007219671536 -3.615193916187478 -3.146497319077316 100.0 0.0024478780047466585 0.0002835421246165922 0.0008331125555818325 8.633207528005576 2.0 -2.611210229984628 -3.547382410741075 -3.0792963203628516 250.0 0.004295906517331518 0.0005326782249155953 0.0015127246471369105 8.064730857005125 2.3979400086720375 -2.3669451778319663 -3.2735350561573275 -2.820240116994647 500.0 0.006698259949577215 0.0009603706235190643 0.002536298894899464 6.974661433346361 2.6989700043360187 -2.1740380021415846 -3.0175611329118577 -2.595799567526721 1000.0 0.009760956536503726 0.0018648778813969691 0.004266496448633582 5.23409958039282 3.0 -2.010507621045406 -2.7293496020171526 -2.369928611531279 2500.0 0.012229965366095462 0.003069990765860003 0.006127469358609696 3.983714056113604 3.3979400086720375 -1.9125747728357445 -2.5128629308231645 -2.2127188518294543 5000.0 0.012229965366095462 0.003069990765860003 0.006127469358609696 3.983714056113604 3.6989700043360187 -1.9125747728357445 -2.5128629308231645 -2.2127188518294543 10000.0 0.012229965366095462 0.003069990765860003 0.006127469358609696 3.983714056113604 4.0 -1.9125747728357445 -2.5128629308231645 -2.2127188518294543 ==> diazepam_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 2.5667771616235213e-09 5.427520520189895e-10 1.180306558291804e-09 4.7291892348915825 -6.0 -8.590611833579462 -9.265398525904239 -8.92800517974185 5e-06 1.2833885808117609e-08 2.7137602600949478e-09 5.901532791459018e-09 4.7291892348915825 -5.301029995663981 -7.891641829243444 -8.56642852156822 -8.229035175405832 1e-05 2.5667771616235218e-08 5.4275205201898956e-09 1.1803065582918038e-08 4.7291892348915825 -5.0 -7.590611833579462 -8.265398525904239 -7.928005179741851 5e-05 1.283388580811761e-07 2.713760260094947e-08 5.901532791459019e-08 4.729189234891584 -4.301029995663981 -6.891641829243444 -7.566428521568221 -7.229035175405833 0.0001 2.566777161623522e-07 5.427520520189894e-08 1.1803065582918038e-07 4.729189234891584 -4.0 -6.590611833579462 -7.2653985259042395 -6.928005179741851 0.001 2.566777161623521e-06 5.427520520189895e-07 1.180306558291804e-06 4.7291892348915825 -3.0 -5.590611833579462 -6.2653985259042395 -5.928005179741851 0.01 2.5667771616235215e-05 5.4275205201898955e-06 1.1803065582918038e-05 4.7291892348915825 -2.0 -4.590611833579462 -5.2653985259042395 -4.928005179741851 0.1 0.00025667771616235215 5.427520520189896e-05 0.00011803065582918038 4.729189234891582 -1.0 -3.590611833579463 -4.2653985259042395 -3.928005179741851 1.0 0.002566777161623521 0.0005427520520189895 0.0011803065582918037 4.7291892348915825 0.0 -2.590611833579463 -3.2653985259042395 -2.928005179741851 10.0 0.02914643425137986 0.007387058455325251 0.014673323194806182 3.945607636334394 1.0 -1.5354145688525473 -2.13152846430313 -1.8334715165778388 25.0 0.04304834667901647 0.01562551064987814 0.025935543169415556 2.755004149534927 1.3979400086720377 -1.3660435234662645 -1.8061657807806615 -1.586104652123463 50.0 0.06017110980500002 0.029543759054530352 0.04216255175060695 2.036677516017487 1.6989700043360187 -1.220611978241723 -1.5295342472510192 -1.3750731127463711 75.0 0.07694541944078016 0.043699841111011474 0.057987089975116236 1.7607711489228155 1.8750612633917 -1.1138172286044825 -1.359520142085331 -1.236668685344907 100.0 0.09433996794148862 0.05809373482163821 0.07403081169806726 1.62392671483655 2.0 -1.0253042756717983 -1.2358707020176944 -1.1305874888447462 250.0 0.107070141899341 0.06905679567117806 0.08598791142728629 1.5504649594395878 2.3979400086720375 -0.9703316217567315 -1.1607935773710367 -1.0655625995638842 500.0 0.107070141899341 0.06905679567117806 0.08598791142728629 1.5504649594395878 2.6989700043360187 -0.9703316217567315 -1.1607935773710367 -1.0655625995638842 1000.0 0.107070141899341 0.06905679567117806 0.08598791142728629 1.5504649594395878 3.0 -0.9703316217567315 -1.1607935773710367 -1.0655625995638842 2500.0 0.107070141899341 0.06905679567117806 0.08598791142728629 1.5504649594395878 3.3979400086720375 -0.9703316217567315 -1.1607935773710367 -1.0655625995638842 5000.0 0.107070141899341 0.06905679567117806 0.08598791142728629 1.5504649594395878 3.6989700043360187 -0.9703316217567315 -1.1607935773710367 -1.0655625995638842 10000.0 0.107070141899341 0.06905679567117806 0.08598791142728629 1.5504649594395878 4.0 -0.9703316217567315 -1.1607935773710367 -1.0655625995638842 ==> diazepam_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 8.958047645315922e-10 5.492438606721773e-10 7.014379995978703e-10 1.6309782023512938 -6.0 -9.047786631995956 -9.260234788829113 -9.154010710412535 5e-06 4.479023822657962e-09 2.7462193033608868e-09 3.5071899979893503e-09 1.630978202351294 -5.301029995663981 -8.348816627659938 -8.561264784493094 -8.455040706076517 1e-05 8.958047645315924e-09 5.4924386067217735e-09 7.014379995978702e-09 1.630978202351294 -5.0 -8.047786631995956 -8.260234788829113 -8.154010710412535 5e-05 4.4790238226579615e-08 2.7462193033608868e-08 3.507189997989351e-08 1.6309782023512938 -4.301029995663981 -7.348816627659938 -7.561264784493095 -7.455040706076517 0.0001 8.958047645315923e-08 5.4924386067217735e-08 7.014379995978703e-08 1.6309782023512938 -4.0 -7.047786631995956 -7.260234788829114 -7.1540107104125354 0.001 8.958047645315924e-07 5.492438606721773e-07 7.014379995978702e-07 1.630978202351294 -3.0 -6.047786631995956 -6.260234788829114 -6.1540107104125354 0.01 8.958047645315923e-06 5.492438606721774e-06 7.014379995978702e-06 1.6309782023512935 -2.0 -5.047786631995956 -5.260234788829114 -5.1540107104125354 0.1 8.958047645315924e-05 5.4924386067217716e-05 7.014379995978702e-05 1.6309782023512946 -1.0 -4.047786631995956 -4.260234788829114 -4.1540107104125354 1.0 0.0008958047645315923 0.0005492438606721773 0.0007014379995978709 1.6309782023512938 0.0 -3.0477866319959563 -3.260234788829113 -3.1540107104125346 10.0 0.01209771575999276 0.0074797720153643 0.009512526257068912 1.6173909759739575 1.0 -1.9172966236075446 -2.1261116392983976 -2.0217041314529713 25.0 0.025230059636949183 0.015840914086934273 0.01999167844672228 1.5927148836542937 1.3979400086720377 -1.5980817229280322 -1.8002197614171358 -1.699150742172584 50.0 0.04623898412552218 0.03002040544923095 0.037257389213533595 1.5402518198403183 1.6989700043360187 -1.3349917159700202 -1.5225834465639474 -1.4287875812669837 75.0 0.06623711350623888 0.04452307825284086 0.054305434238946806 1.4877029195979397 1.8750612633917 -1.178898601579859 -1.3514148168888303 -1.2651567092343445 100.0 0.08537787203613187 0.05936877431030332 0.07119536232091996 1.4380938974735533 2.0 -1.0686546737822766 -1.226441917147154 -1.1475482954647154 250.0 0.09981131304467143 0.07075328023565194 0.08403557462490525 1.4106952032787508 2.3979400086720375 -1.0008202311132044 -1.1502534207475679 -1.0755368259303861 500.0 0.09981131304467143 0.07075328023565194 0.08403557462490525 1.4106952032787508 2.6989700043360187 -1.0008202311132044 -1.1502534207475679 -1.0755368259303861 1000.0 0.09981131304467143 0.07075328023565194 0.08403557462490525 1.4106952032787508 3.0 -1.0008202311132044 -1.1502534207475679 -1.0755368259303861 2500.0 0.09981131304467143 0.07075328023565194 0.08403557462490525 1.4106952032787508 3.3979400086720375 -1.0008202311132044 -1.1502534207475679 -1.0755368259303861 5000.0 0.09981131304467143 0.07075328023565194 0.08403557462490525 1.4106952032787508 3.6989700043360187 -1.0008202311132044 -1.1502534207475679 -1.0755368259303861 10000.0 0.09981131304467143 0.07075328023565194 0.08403557462490525 1.4106952032787508 4.0 -1.0008202311132044 -1.1502534207475679 -1.0755368259303861 ==> diazepam_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 3.6737626251596867e-09 2.654449371754299e-10 9.875128805402782e-10 13.840017685972041 -6.0 -8.434888908431338 -9.576025553531496 -9.005457230981417 5e-06 1.8368813125798442e-08 1.3272246858771493e-09 4.93756440270139e-09 13.840017685972047 -5.301029995663981 -7.735918904095319 -8.877055549195477 -8.306487226645398 1e-05 3.6737626251596884e-08 2.6544493717542987e-09 9.875128805402782e-09 13.840017685972047 -5.0 -7.434888908431338 -8.576025553531496 -8.005457230981417 5e-05 1.8368813125798434e-07 1.3272246858771494e-08 4.93756440270139e-08 13.840017685972041 -4.301029995663981 -6.735918904095319 -7.877055549195477 -7.306487226645398 0.0001 3.673762625159687e-07 2.6544493717542988e-08 9.875128805402782e-08 13.840017685972041 -4.0 -6.434888908431338 -7.576025553531496 -7.005457230981417 0.001 3.6737626251596875e-06 2.654449371754299e-07 9.875128805402762e-07 13.840017685972043 -3.0 -5.434888908431338 -6.576025553531496 -6.005457230981418 0.01 3.6737626251596876e-05 2.654449371754298e-06 9.875128805402762e-06 13.840017685972049 -2.0 -4.434888908431338 -5.576025553531496 -5.005457230981418 0.1 0.00036737626251596875 2.6544493717542986e-05 9.875128805402771e-05 13.840017685972045 -1.0 -3.434888908431338 -4.576025553531496 -4.005457230981417 1.0 0.0036737626251596876 0.00026544493717542986 0.000987512880540277 13.840017685972045 0.0 -2.434888908431338 -3.576025553531496 -3.005457230981417 10.0 0.04746037199689418 0.0036087791814473466 0.013087169380967692 13.151364938283532 1.0 -1.3236688620823274 -2.4426396912884822 -1.8831542766854048 25.0 0.08529740538195821 0.007616755704391506 0.025489007415213816 11.198653165780183 1.3979400086720377 -1.0690641792127376 -2.1182299735041785 -1.593647076358458 50.0 0.12460283299096983 0.014347605455642492 0.04228181980957949 8.68457342071441 1.6989700043360187 -0.9044720833722053 -1.843220574482359 -1.3738463289272822 75.0 0.14537096626010332 0.021143835927531596 0.05544095831810951 6.8753355237123435 1.8750612633917 -0.8375223228587362 -1.6748162199124852 -1.2561692713856107 100.0 0.16029584252079454 0.02800729868607126 0.06700338453850921 5.723359625557667 2.0 -0.79507774148673 -1.5527287770138987 -1.1739032592503142 250.0 0.16856090554331776 0.03320817755458095 0.07481711355060047 5.07588545822098 2.3979400086720375 -0.7732431442757888 -1.478754957575556 -1.1259990509256725 500.0 0.16856090554331776 0.03320817755458095 0.07481711355060047 5.07588545822098 2.6989700043360187 -0.7732431442757888 -1.478754957575556 -1.1259990509256725 1000.0 0.16856090554331776 0.03320817755458095 0.07481711355060047 5.07588545822098 3.0 -0.7732431442757888 -1.478754957575556 -1.1259990509256725 2500.0 0.16856090554331776 0.03320817755458095 0.07481711355060047 5.07588545822098 3.3979400086720375 -0.7732431442757888 -1.478754957575556 -1.1259990509256725 5000.0 0.16856090554331776 0.03320817755458095 0.07481711355060047 5.07588545822098 3.6989700043360187 -0.7732431442757888 -1.478754957575556 -1.1259990509256725 10000.0 0.16856090554331776 0.03320817755458095 0.07481711355060047 5.07588545822098 4.0 -0.7732431442757888 -1.478754957575556 -1.1259990509256725 ==> diazepam_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 8.556074972785532e-10 4.992938015145412e-10 6.536050182798103e-10 1.7136353279034946 -6.0 -9.067725418569374 -9.301643825462495 -9.184684622015935 5e-06 4.2780374863927655e-09 2.4964690075727072e-09 3.2680250913990513e-09 1.7136353279034937 -5.301029995663981 -8.368755414233355 -8.602673821126476 -8.485714617679916 1e-05 8.556074972785531e-09 4.9929380151454145e-09 6.536050182798103e-09 1.7136353279034937 -5.0 -8.067725418569374 -8.301643825462495 -8.184684622015935 5e-05 4.2780374863927665e-08 2.4964690075727074e-08 3.2680250913990577e-08 1.713635327903494 -4.301029995663981 -7.368755414233355 -7.602673821126477 -7.485714617679916 0.0001 8.556074972785533e-08 4.992938015145415e-08 6.536050182798103e-08 1.713635327903494 -4.0 -7.067725418569374 -7.301643825462496 -7.1846846220159355 0.001 8.556074972785532e-07 4.992938015145414e-07 6.536050182798117e-07 1.7136353279034942 -3.0 -6.067725418569374 -6.301643825462496 -6.184684622015935 0.01 8.55607497278553e-06 4.992938015145416e-06 6.536050182798103e-06 1.713635327903493 -2.0 -5.067725418569374 -5.301643825462496 -5.1846846220159355 0.1 8.556074972785532e-05 4.992938015145414e-05 6.536050182798104e-05 1.713635327903494 -1.0 -4.067725418569374 -4.301643825462496 -4.1846846220159355 1.0 0.0008556074972785531 0.0004992938015145415 0.0006536050182798107 1.7136353279034933 0.0 -3.0677254185693745 -3.3016438254624956 -3.184684622015935 10.0 0.011581398841472848 0.00681324907171324 0.008882958679730851 1.6998349421211785 1.0 -1.9362389818484178 -2.1666457342818792 -2.0514423580651484 25.0 0.02416673780313072 0.01448657042841536 0.01871077628560881 1.6682166370949845 1.3979400086720377 -1.6167819697709447 -1.8390344178626523 -1.7279081938167986 50.0 0.044581983873921205 0.027638830762955015 0.03510261966531982 1.6130198942306744 1.6989700043360187 -1.3508406095586423 -1.558480333365039 -1.4546604714618407 75.0 0.06431261797125475 0.041264725551191254 0.05151545913667507 1.5585373975520875 1.8750612633917 -1.1917038112487033 -1.3844210390073086 -1.288062425128006 100.0 0.08314747627464888 0.055383593793695854 0.06786019489336967 1.5013015692765195 2.0 -1.0801509281236847 -1.2566188666812392 -1.1683848974024622 250.0 0.0975611463346044 0.06631724287258864 0.08043622465282742 1.4711279014123493 2.3979400086720375 -1.0107231054076278 -1.1783735377972169 -1.0945483216024223 500.0 0.0975611463346044 0.06631724287258864 0.08043622465282742 1.4711279014123493 2.6989700043360187 -1.0107231054076278 -1.1783735377972169 -1.0945483216024223 1000.0 0.0975611463346044 0.06631724287258864 0.08043622465282742 1.4711279014123493 3.0 -1.0107231054076278 -1.1783735377972169 -1.0945483216024223 2500.0 0.0975611463346044 0.06631724287258864 0.08043622465282742 1.4711279014123493 3.3979400086720375 -1.0107231054076278 -1.1783735377972169 -1.0945483216024223 5000.0 0.0975611463346044 0.06631724287258864 0.08043622465282742 1.4711279014123493 3.6989700043360187 -1.0107231054076278 -1.1783735377972169 -1.0945483216024223 10000.0 0.0975611463346044 0.06631724287258864 0.08043622465282742 1.4711279014123493 4.0 -1.0107231054076278 -1.1783735377972169 -1.0945483216024223 ==> diazepam_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.0642548713559388e-09 4.2802756044260367e-10 6.749299343455135e-10 2.4864166930172478 -6.0 -8.972954353273765 -9.368528266120512 -9.170741309697139 5e-06 5.321274356779694e-09 2.1401378022130193e-09 3.374649671727567e-09 2.486416693017247 -5.301029995663981 -8.273984348937747 -8.669558261784491 -8.47177130536112 1e-05 1.0642548713559388e-08 4.280275604426039e-09 6.7492993434551345e-09 2.486416693017247 -5.0 -7.9729543532737654 -8.36852826612051 -8.170741309697139 5e-05 5.3212743567796945e-08 2.1401378022130187e-08 3.374649671727567e-08 2.4864166930172478 -4.301029995663981 -7.273984348937747 -7.669558261784492 -7.47177130536112 0.0001 1.0642548713559389e-07 4.2802756044260374e-08 6.749299343455135e-08 2.4864166930172478 -4.0 -6.9729543532737654 -7.368528266120511 -7.170741309697139 0.001 1.0642548713559387e-06 4.2802756044260377e-07 6.749299343455135e-07 2.486416693017247 -3.0 -5.9729543532737654 -6.368528266120511 -6.170741309697139 0.01 1.0642548713559388e-05 4.280275604426038e-06 6.749299343455134e-06 2.4864166930172473 -2.0 -4.9729543532737654 -5.368528266120511 -5.170741309697139 0.1 0.00010642548713559388 4.280275604426038e-05 6.749299343455135e-05 2.486416693017247 -1.0 -3.9729543532737654 -4.368528266120511 -4.170741309697139 1.0 0.0010642548713559387 0.0004280275604426038 0.0006749299343455137 2.486416693017247 0.0 -2.9729543532737654 -3.368528266120511 -3.170741309697138 10.0 0.014325570029023415 0.005842927665460542 0.009148949089708243 2.4517794587303463 1.0 -1.8438880879969433 -2.2333694901548684 -2.038628789075906 25.0 0.02971403613932761 0.01243527722148266 0.019222442008280143 2.38949527301208 1.3979400086720377 -1.5270383527744578 -1.9053445284947148 -1.7161914406345864 50.0 0.05366229409772903 0.023780779557702567 0.03572297841024314 2.2565405800731155 1.6989700043360187 -1.2703307648976274 -1.6237739128771522 -1.44705233888739 75.0 0.07565498322472902 0.03562348555758158 0.051914296703944776 2.123738933475243 1.8750612633917 -1.121162460691353 -1.4482635895228244 -1.2847130251070886 100.0 0.09596552636910653 0.048024927725315844 0.06788768274140924 1.9982440560450714 2.0 -1.0178847502571446 -1.3185332800533616 -1.168209015155253 250.0 0.11121836836947356 0.057741044803765296 0.08013653842675916 1.9261578786364635 2.3979400086720375 -0.9538234805352552 -1.2385153619792908 -1.096169421257273 500.0 0.11121836836947356 0.057741044803765296 0.08013653842675916 1.9261578786364635 2.6989700043360187 -0.9538234805352552 -1.2385153619792908 -1.096169421257273 1000.0 0.11121836836947356 0.057741044803765296 0.08013653842675916 1.9261578786364635 3.0 -0.9538234805352552 -1.2385153619792908 -1.096169421257273 2500.0 0.11121836836947356 0.057741044803765296 0.08013653842675916 1.9261578786364635 3.3979400086720375 -0.9538234805352552 -1.2385153619792908 -1.096169421257273 5000.0 0.11121836836947356 0.057741044803765296 0.08013653842675916 1.9261578786364635 3.6989700043360187 -0.9538234805352552 -1.2385153619792908 -1.096169421257273 10000.0 0.11121836836947356 0.057741044803765296 0.08013653842675916 1.9261578786364635 4.0 -0.9538234805352552 -1.2385153619792908 -1.096169421257273 ==> diclofenac_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.346541619759964e-10 3.4977243011584454e-16 2.1702145852324527e-13 384976.48865978076 -6.0 -9.870780218596513 -15.456214425619008 -12.66349732210776 5e-06 6.732708098799822e-10 1.748862150579222e-15 1.0851072926162262e-12 384976.48865978105 -5.301029995663981 -9.171810214260494 -14.757244421282989 -11.964527317771742 1e-05 1.3465416197599644e-09 3.497724301158444e-15 2.1702145852324525e-12 384976.48865978105 -5.0 -8.870780218596513 -14.456214425619008 -11.66349732210776 5e-05 6.732708098799821e-09 1.748862150579222e-14 1.0851072926162263e-11 384976.488659781 -4.301029995663981 -8.171810214260494 -13.757244421282989 -10.964527317771742 0.0001 1.3465416197599641e-08 3.497724301158444e-14 2.1702145852324526e-11 384976.488659781 -4.0 -7.870780218596513 -13.456214425619008 -10.66349732210776 0.001 1.3465416197599642e-07 3.4977243011584443e-13 2.1702145852324526e-10 384976.488659781 -3.0 -6.870780218596513 -12.456214425619008 -9.66349732210776 0.01 1.3465416197599637e-06 3.4977243011584437e-12 2.1702145852324524e-09 384976.48865978094 -2.0 -5.870780218596513 -11.456214425619008 -8.66349732210776 0.1 1.3465416197599643e-05 3.497724301158444e-11 2.170214585232453e-08 384976.488659781 -1.0 -4.870780218596513 -10.456214425619008 -7.663497322107761 1.0 0.00013465416197599642 3.497724301158444e-10 2.1702145852324572e-07 384976.488659781 0.0 -3.870780218596513 -9.456214425619008 -6.6634973221077605 10.0 0.0013465416197599642 3.497724301158444e-09 2.170214585232455e-06 384976.488659781 1.0 -2.870780218596513 -8.456214425619008 -5.6634973221077605 25.0 0.006189245995288722 1.641897425879722e-08 1.0080727685936629e-05 376956.9217743641 1.3979400086720377 -2.2083622556698717 -7.784653978011886 -4.996508116840879 50.0 0.008672604003117989 2.785939554535803e-08 1.5543921813079214e-05 311299.0728387512 1.6989700043360187 -2.061850483332612 -7.555028310530984 -4.808439396931798 75.0 0.011836453968780889 4.153257861204555e-08 2.2172019640669883e-05 284992.0319021079 1.8750612633917 -1.9267783865026482 -7.381611104232838 -4.654194745367743 100.0 0.013973854310875743 5.787427884189287e-08 2.8438121261497027e-05 241451.89522017215 2.0 -1.8546837889414558 -7.237514407584147 -4.546099098262801 250.0 0.020722081599312436 2.4946844743085046e-07 7.189927346027825e-05 83064.93992614573 2.3979400086720375 -1.6835666204669977 -6.602984375784936 -4.143275498125966 500.0 0.02426381493825227 1.6908358189485203e-06 0.00020254907405844913 14350.189809286867 2.6989700043360187 -1.615040915077971 -5.771898560578695 -3.693469737828333 1000.0 0.02472153701715845 3.3884917053870912e-06 0.0002894282693985875 7295.734848002036 3.0 -1.6069245312644835 -5.469993573122384 -3.538459052193434 2500.0 0.02472153701715845 3.3884917053870912e-06 0.0002894282693985875 7295.734848002036 3.3979400086720375 -1.6069245312644835 -5.469993573122384 -3.538459052193434 5000.0 0.02472153701715845 3.3884917053870912e-06 0.0002894282693985875 7295.734848002036 3.6989700043360187 -1.6069245312644835 -5.469993573122384 -3.538459052193434 10000.0 0.02472153701715845 3.3884917053870912e-06 0.0002894282693985875 7295.734848002036 4.0 -1.6069245312644835 -5.469993573122384 -3.538459052193434 ==> diclofenac_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.4885269513843924e-10 3.4608799072158097e-16 2.269716505952992e-13 430100.7233105279 -6.0 -9.827243297576507 -15.460813470494482 -12.644028384035494 5e-06 7.442634756921964e-10 1.7304399536079048e-15 1.1348582529764958e-12 430100.723310528 -5.301029995663981 -9.128273293240488 -14.761843466158464 -11.945058379699475 1e-05 1.4885269513843927e-09 3.4608799072158097e-15 2.2697165059529916e-12 430100.723310528 -5.0 -8.827243297576507 -14.460813470494482 -11.644028384035494 5e-05 7.442634756921964e-09 1.730439953607905e-14 1.134858252976496e-11 430100.7233105279 -4.301029995663981 -8.128273293240488 -13.761843466158464 -10.945058379699475 0.0001 1.4885269513843928e-08 3.46087990721581e-14 2.269716505952992e-11 430100.7233105279 -4.0 -7.827243297576507 -13.460813470494482 -10.644028384035494 0.001 1.4885269513843927e-07 3.4608799072158105e-13 2.269716505952992e-10 430100.72331052786 -3.0 -6.827243297576507 -12.460813470494482 -9.644028384035494 0.01 1.4885269513843927e-06 3.46087990721581e-12 2.269716505952992e-09 430100.723310528 -2.0 -5.827243297576507 -11.460813470494482 -8.644028384035494 0.1 1.4885269513843928e-05 3.46087990721581e-11 2.269716505952992e-08 430100.723310528 -1.0 -4.827243297576507 -10.460813470494482 -7.644028384035495 1.0 0.00014885269513843926 3.460879907215809e-10 2.269716505952992e-07 430100.72331052803 0.0 -3.8272432975765063 -9.460813470494482 -6.644028384035495 10.0 0.001488526951384393 3.4608799072158097e-09 2.2697165059529897e-06 430100.72331052803 1.0 -2.8272432975765063 -8.460813470494482 -5.644028384035495 25.0 0.006689500608191553 1.6246019754091057e-08 1.0424862542292057e-05 411762.43224171933 1.3979400086720377 -2.174606302441745 -7.789253023027839 -4.981929662734792 50.0 0.00931780135533366 2.7565929712352122e-08 1.6026660826098092e-05 338018.75911910244 1.6989700043360187 -2.0306865524413538 -7.559627355546937 -4.795156953994145 75.0 0.012115353737734773 4.109508194204695e-08 2.2313257373344108e-05 294812.7407269821 1.8750612633917 -1.9166639010391882 -7.38621014924879 -4.65143702514399 100.0 0.014158780479638502 5.726464165783051e-08 2.8474505974263784e-05 247251.70837950046 2.0 -1.848974151573646 -7.2421134526001 -4.545543802086873 250.0 0.020767147372860437 2.468405919335985e-07 7.159731105487928e-05 84131.81644956887 2.3979400086720375 -1.6826231551408557 -6.607583420800888 -4.145103287970873 500.0 0.024283637010678774 1.673024860298105e-06 0.00020156172359185853 14514.809425098343 2.6989700043360187 -1.6146862675400464 -5.776497605594647 -3.695591936567347 1000.0 0.02472447443970002 3.352797946729046e-06 0.0002879169448562919 7374.281072863621 3.0 -1.606872931292525 -5.474592618138337 -3.540732774715431 2500.0 0.02472447443970002 3.352797946729046e-06 0.0002879169448562919 7374.281072863621 3.3979400086720375 -1.606872931292525 -5.474592618138337 -3.540732774715431 5000.0 0.02472447443970002 3.352797946729046e-06 0.0002879169448562919 7374.281072863621 3.6989700043360187 -1.606872931292525 -5.474592618138337 -3.540732774715431 10000.0 0.02472447443970002 3.352797946729046e-06 0.0002879169448562919 7374.281072863621 4.0 -1.606872931292525 -5.474592618138337 -3.540732774715431 ==> diclofenac_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 2.2475983597352196e-10 3.4939713637985144e-14 2.8023283723067412e-12 6432.789870640826 -6.0 -9.648281293518854 -13.456680658767871 -11.552480976143363 5e-06 1.1237991798676102e-09 1.746985681899257e-13 1.4011641861533705e-11 6432.789870640829 -5.301029995663981 -8.949311289182836 -12.757710654431852 -10.853510971807344 1e-05 2.2475983597352204e-09 3.493971363798514e-13 2.802328372306741e-11 6432.789870640829 -5.0 -8.648281293518854 -12.456680658767871 -10.552480976143363 5e-05 1.1237991798676103e-08 1.7469856818992572e-12 1.4011641861533704e-10 6432.789870640829 -4.301029995663981 -7.949311289182836 -11.757710654431852 -9.853510971807344 0.0001 2.2475983597352205e-08 3.4939713637985143e-12 2.8023283723067413e-10 6432.789870640829 -4.0 -7.648281293518854 -11.456680658767871 -9.552480976143363 0.001 2.24759835973522e-07 3.493971363798514e-11 2.802328372306747e-09 6432.789870640828 -3.0 -6.648281293518854 -10.456680658767871 -8.552480976143363 0.01 2.2475983597352203e-06 3.493971363798514e-10 2.8023283723067468e-08 6432.789870640829 -2.0 -5.648281293518854 -9.456680658767871 -7.552480976143363 0.1 2.24759835973522e-05 3.4939713637985134e-09 2.802328372306747e-07 6432.78987064083 -1.0 -4.648281293518854 -8.456680658767871 -6.552480976143363 1.0 0.00022475983597352198 3.4939713637985135e-08 2.802328372306747e-06 6432.789870640829 0.0 -3.6482812935188544 -7.456680658767871 -5.552480976143363 10.0 0.00224759835973522 3.4939713637985143e-07 2.802328372306744e-05 6432.789870640827 1.0 -2.6482812935188544 -6.456680658767871 -4.552480976143363 25.0 0.010745532743765362 1.6016901954695275e-06 0.0001311907559273356 6708.870900352464 1.3979400086720377 -1.9687720481165045 -5.795421482889379 -3.8820967655029417 50.0 0.014030468555140412 2.6139945477276196e-06 0.00019150866378626544 5367.443695449666 1.6989700043360187 -1.852927825228656 -5.5826953226063845 -3.71781157391752 75.0 0.016187109621275595 3.7305911195763974e-06 0.0002457386567163181 4339.020037959457 1.8750612633917 -1.7908306921728323 -5.428222347915118 -3.609526520043975 100.0 0.01703847454018535 4.96222457198038e-06 0.00029077265523492726 3433.63632440066 2.0 -1.76856929034607 -5.304323585052745 -3.5364464376994076 250.0 0.02035004593483223 1.552437947639588e-05 0.0005620692443591116 1310.8444022367244 2.3979400086720375 -1.691434606133029 -4.80898574995093 -3.2502101780419794 500.0 0.023239260488280424 5.506848324243565e-05 0.001131260724486388 422.0065474832672 2.6989700043360187 -1.6337776960308064 -4.259096885176827 -2.9464372906038165 1000.0 0.02397070030105647 8.41663188714364e-05 0.001420396284531312 284.8015764794417 3.0 -1.6203192779212152 -4.0748616668692765 -2.847590472395246 2500.0 0.02397070030105647 8.41663188714364e-05 0.001420396284531312 284.8015764794417 3.3979400086720375 -1.6203192779212152 -4.0748616668692765 -2.847590472395246 5000.0 0.02397070030105647 8.41663188714364e-05 0.001420396284531312 284.8015764794417 3.6989700043360187 -1.6203192779212152 -4.0748616668692765 -2.847590472395246 10000.0 0.02397070030105647 8.41663188714364e-05 0.001420396284531312 284.8015764794417 4.0 -1.6203192779212152 -4.0748616668692765 -2.847590472395246 ==> diclofenac_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.8472377084007856e-10 2.685800596389358e-14 2.2274003095303155e-12 6877.79171277313 -6.0 -9.733477214573757 -13.570926234073275 -11.652201724323515 5e-06 9.236188542003931e-10 1.342900298194679e-13 1.1137001547651577e-11 6877.7917127731325 -5.301029995663981 -9.034507210237738 -12.871956229737256 -10.953231719987496 1e-05 1.8472377084007861e-09 2.685800596389358e-13 2.2274003095303154e-11 6877.7917127731325 -5.0 -8.733477214573757 -12.570926234073275 -10.652201724323515 5e-05 9.23618854200393e-09 1.342900298194679e-12 1.1137001547651576e-10 6877.791712773132 -4.301029995663981 -8.034507210237738 -11.871956229737256 -9.953231719987496 0.0001 1.847237708400786e-08 2.685800596389358e-12 2.2274003095303154e-10 6877.791712773132 -4.0 -7.733477214573757 -11.570926234073275 -9.652201724323515 0.001 1.847237708400786e-07 2.6858005963893577e-11 2.227400309530315e-09 6877.791712773132 -3.0 -6.733477214573757 -10.570926234073275 -8.652201724323515 0.01 1.8472377084007858e-06 2.685800596389358e-10 2.2274003095303153e-08 6877.791712773131 -2.0 -5.733477214573757 -9.570926234073275 -7.652201724323516 0.1 1.847237708400786e-05 2.685800596389358e-09 2.2274003095303155e-07 6877.791712773132 -1.0 -4.733477214573757 -8.570926234073275 -6.652201724323516 1.0 0.0001847237708400786 2.6858005963893583e-08 2.227400309530313e-06 6877.79171277313 0.0 -3.7334772145737563 -7.570926234073275 -5.652201724323516 10.0 0.001847237708400786 2.685800596389358e-07 2.227400309530313e-05 6877.791712773132 1.0 -2.7334772145737563 -6.570926234073275 -4.652201724323516 25.0 0.008147286727413423 1.2312122895083946e-06 0.00010015507747957682 6617.28833998767 1.3979400086720377 -2.0889869992972807 -5.909667058187101 -3.999327028742191 50.0 0.011302940860401633 2.009366243881178e-06 0.0001507041732052445 5625.12727324886 1.6989700043360187 -1.946808544722268 -5.696940897895776 -3.821874721309022 75.0 0.014390348326079048 2.8676891740733043e-06 0.00020314292039310842 5018.0990520806 1.8750612633917 -1.8419286936059132 -5.542467923192608 -3.6921983083992607 100.0 0.016372688715412576 3.814440454288282e-06 0.00024990527441720595 4292.2910743058055 2.0 -1.7858799950912514 -5.418569160313994 -3.6022245777026223 250.0 0.0211734463613243 1.1933523017329806e-05 0.0005026666982296138 1774.282944824954 2.3979400086720375 -1.6742084469456908 -4.923231324886548 -3.2987198859161193 500.0 0.02366099819978533 4.233090458348425e-05 0.0010007954122322432 558.9532856100802 2.6989700043360187 -1.6259669374970125 -4.37334245084047 -2.999654694168741 1000.0 0.024208591667555436 6.469828830171794e-05 0.0012515008761827008 374.17669467018374 3.0 -1.6160304748622656 -4.189107209145089 -2.9025688420036775 2500.0 0.024208591667555436 6.469828830171794e-05 0.0012515008761827008 374.17669467018374 3.3979400086720375 -1.6160304748622656 -4.189107209145089 -2.9025688420036775 5000.0 0.024208591667555436 6.469828830171794e-05 0.0012515008761827008 374.17669467018374 3.6989700043360187 -1.6160304748622656 -4.189107209145089 -2.9025688420036775 10000.0 0.024208591667555436 6.469828830171794e-05 0.0012515008761827008 374.17669467018374 4.0 -1.6160304748622656 -4.189107209145089 -2.9025688420036775 ==> diclofenac_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.8971600007612226e-10 7.125764536988127e-15 1.1627001098484804e-12 26623.95018686798 -6.0 -9.721896040478002 -14.147168532528966 -11.934532286503483 5e-06 9.485800003806115e-10 3.562882268494064e-14 5.813500549242401e-12 26623.95018686798 -5.301029995663981 -9.022926036141984 -13.448198528192945 -11.235562282167464 1e-05 1.897160000761223e-09 7.125764536988128e-14 1.1627001098484804e-11 26623.95018686798 -5.0 -8.721896040478002 -13.147168532528964 -10.934532286503483 5e-05 9.485800003806117e-09 3.5628822684940634e-13 5.813500549242401e-11 26623.95018686799 -4.301029995663981 -8.022926036141984 -12.448198528192945 -10.235562282167464 0.0001 1.8971600007612233e-08 7.125764536988127e-13 1.1627001098484804e-10 26623.95018686799 -4.0 -7.721896040478002 -12.147168532528966 -9.934532286503483 0.001 1.8971600007612232e-07 7.125764536988126e-12 1.1627001098484804e-09 26623.95018686799 -3.0 -6.721896040478002 -11.147168532528966 -8.934532286503483 0.01 1.897160000761223e-06 7.125764536988127e-11 1.1627001098484804e-08 26623.950186867984 -2.0 -5.721896040478002 -10.147168532528966 -7.934532286503484 0.1 1.8971600007612234e-05 7.125764536988126e-10 1.1627001098484804e-07 26623.950186867994 -1.0 -4.721896040478002 -9.147168532528966 -6.934532286503484 1.0 0.00018971600007612228 7.1257645369881245e-09 1.1627001098484805e-06 26623.95018686799 0.0 -3.721896040478003 -8.147168532528966 -5.934532286503484 10.0 0.001897160000761223 7.125764536988127e-08 1.1627001098484804e-05 26623.950186867984 1.0 -2.721896040478003 -7.147168532528965 -4.934532286503484 25.0 0.008882582712752293 3.2938980184463847e-07 5.409096190328003e-05 26966.781190578247 1.3979400086720377 -2.0514607397604294 -6.48228985104107 -4.26687529540075 50.0 0.01089296201710128 5.449080549202625e-07 7.704325243042998e-05 19990.458791612593 1.6989700043360187 -1.9628540107153825 -6.2636767722361615 -4.113265391475772 75.0 0.01441642087300267 7.894946692394834e-07 0.00010668499158151733 18260.31439438336 1.8750612633917 -1.841142547386479 -6.102650798053018 -3.9718966727197484 100.0 0.01593076561050622 1.0670702854558926e-06 0.00013038115894382059 14929.443568658646 2.0 -1.7977633521066991 -5.971806973658625 -3.8847851628826615 250.0 0.020472633426651655 3.721321074994238e-06 0.0002760167426646984 5501.442367932027 2.3979400086720375 -1.6888262897701607 -5.42930285750262 -3.55906457363639 500.0 0.023702683915010802 1.6406995539020326e-05 0.0006236103184332271 1444.669370369446 2.6989700043360187 -1.6252024749399325 -4.784970939988171 -3.205086707464052 1000.0 0.024349507010556003 2.7493629380569684e-05 0.0008182031051932094 885.6417853571672 3.0 -1.613509827252737 -4.560767926001832 -3.0871388766272845 2500.0 0.024349507010556003 2.7493629380569684e-05 0.0008182031051932094 885.6417853571672 3.3979400086720375 -1.613509827252737 -4.560767926001832 -3.0871388766272845 5000.0 0.024349507010556003 2.7493629380569684e-05 0.0008182031051932094 885.6417853571672 3.6989700043360187 -1.613509827252737 -4.560767926001832 -3.0871388766272845 10000.0 0.024349507010556003 2.7493629380569684e-05 0.0008182031051932094 885.6417853571672 4.0 -1.613509827252737 -4.560767926001832 -3.0871388766272845 ==> furosemide_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 2.630339996866434e-10 2.8122917394062815e-14 2.7197947431777665e-12 9353.012562707096 -6.0 -9.579988111122644 -13.550939628800764 -11.565463869961704 5e-06 1.3151699984332175e-09 1.4061458697031407e-13 1.3598973715888832e-11 9353.0125627071 -5.301029995663981 -8.881018106786625 -12.851969624464745 -10.866493865625685 1e-05 2.630339996866435e-09 2.8122917394062815e-13 2.719794743177767e-11 9353.0125627071 -5.0 -8.579988111122644 -12.550939628800764 -10.565463869961704 5e-05 1.315169998433217e-08 1.4061458697031407e-12 1.3598973715888833e-10 9353.012562707096 -4.301029995663981 -7.881018106786625 -11.851969624464745 -9.866493865625685 0.0001 2.630339996866434e-08 2.8122917394062815e-12 2.7197947431777665e-10 9353.012562707096 -4.0 -7.579988111122644 -11.550939628800764 -9.565463869961704 0.001 2.630339996866434e-07 2.812291739406282e-11 2.7197947431777667e-09 9353.012562707094 -3.0 -6.579988111122644 -10.550939628800764 -8.565463869961704 0.01 2.630339996866434e-06 2.8122917394062815e-10 2.7197947431777668e-08 9353.012562707096 -2.0 -5.579988111122644 -9.550939628800764 -7.565463869961704 0.1 2.6303399968664344e-05 2.812291739406282e-09 2.7197947431777667e-07 9353.012562707096 -1.0 -4.579988111122644 -8.550939628800764 -6.565463869961704 1.0 0.0002630339996866434 2.812291739406282e-08 2.7197947431777667e-06 9353.012562707094 0.0 -3.5799881111226437 -7.550939628800763 -5.565463869961704 10.0 0.0026303399968664342 2.8122917394062813e-07 2.719794743177767e-05 9353.012562707097 1.0 -2.5799881111226433 -6.550939628800764 -4.565463869961704 25.0 0.006575849992166086 7.030729348515705e-07 6.799486857944415e-05 9353.012562707096 1.3979400086720377 -2.1820481024506058 -6.152999620128726 -4.167523861289666 50.0 0.013151699984332172 1.406145869703141e-06 0.00013598973715888834 9353.012562707096 1.6989700043360187 -1.8810181067866247 -5.851969624464744 -3.8664938656256846 75.0 0.019727549976498258 2.1092188045547114e-06 0.00020398460573833253 9353.012562707096 1.8750612633917 -1.7049268477309434 -5.675878365409064 -3.6904026065700037 100.0 0.026303399968664345 2.812291739406282e-06 0.00027197947431777683 9353.012562707096 2.0 -1.5799881111226435 -5.550939628800764 -3.5654638699617034 250.0 0.06575849992166086 7.030729348515704e-06 0.000679948685794442 9353.012562707096 2.3979400086720375 -1.1820481024506058 -5.152999620128726 -3.167523861289666 500.0 0.1315169998433217 1.4061458697031408e-05 0.001359897371588884 9353.012562707096 2.6989700043360187 -0.8810181067866247 -4.851969624464744 -2.8664938656256846 1000.0 0.24165799524403384 3.681281472664491e-05 0.0029826349099631787 6564.507415107357 3.0 -0.6167988316737685 -4.434000974905539 -2.5253999032896535 2500.0 0.24165799524403384 3.681281472664491e-05 0.0029826349099631787 6564.507415107357 3.3979400086720375 -0.6167988316737685 -4.434000974905539 -2.5253999032896535 5000.0 0.24165799524403384 3.681281472664491e-05 0.0029826349099631787 6564.507415107357 3.6989700043360187 -0.6167988316737685 -4.434000974905539 -2.5253999032896535 10000.0 0.24165799524403384 3.681281472664491e-05 0.0029826349099631787 6564.507415107357 4.0 -0.6167988316737685 -4.434000974905539 -2.5253999032896535 ==> furosemide_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 2.6391312376980023e-10 2.7749174791473807e-14 2.7061728328493862e-12 9510.66565953846 -6.0 -9.578539012814849 -13.55674992745439 -11.567644470134619 5e-06 1.3195656188490013e-09 1.3874587395736906e-13 1.3530864164246933e-11 9510.66565953846 -5.301029995663981 -8.87956900847883 -12.857779923118372 -10.8686744657986 1e-05 2.6391312376980026e-09 2.774917479147381e-13 2.706172832849387e-11 9510.66565953846 -5.0 -8.578539012814849 -12.55674992745439 -10.567644470134619 5e-05 1.3195656188490012e-08 1.38745873957369e-12 1.3530864164246933e-10 9510.665659538463 -4.301029995663981 -7.879569008478829 -11.857779923118372 -9.8686744657986 0.0001 2.6391312376980025e-08 2.77491747914738e-12 2.706172832849381e-10 9510.665659538463 -4.0 -7.578539012814848 -11.55674992745439 -9.567644470134619 0.001 2.639131237698003e-07 2.77491747914738e-11 2.706172832849381e-09 9510.665659538465 -3.0 -6.578539012814848 -10.55674992745439 -8.567644470134619 0.01 2.6391312376980026e-06 2.7749174791473804e-10 2.706172832849381e-08 9510.665659538461 -2.0 -5.578539012814848 -9.55674992745439 -7.56764447013462 0.1 2.6391312376980025e-05 2.7749174791473804e-09 2.7061728328493814e-07 9510.665659538461 -1.0 -4.578539012814848 -8.55674992745439 -6.56764447013462 1.0 0.00026391312376980024 2.7749174791473808e-08 2.706172832849381e-06 9510.66565953846 0.0 -3.5785390128148484 -7.556749927454391 -5.56764447013462 10.0 0.0026391312376980026 2.77491747914738e-07 2.706172832849381e-05 9510.665659538463 1.0 -2.5785390128148484 -6.556749927454391 -4.56764447013462 25.0 0.006597828094245007 6.937293697868451e-07 6.765432082123451e-05 9510.665659538463 1.3979400086720377 -2.180599004142811 -6.158809918782353 -4.169704461462582 50.0 0.013195656188490014 1.3874587395736901e-06 0.00013530864164246906 9510.665659538463 1.6989700043360187 -1.8795690084788297 -5.857779923118372 -3.8686744657986005 75.0 0.019793484282735016 2.081188109360536e-06 0.0002029629624637036 9510.665659538457 1.8750612633917 -1.7034777494231483 -5.6816886640626905 -3.6925832067429196 100.0 0.026391312376980027 2.7749174791473802e-06 0.0002706172832849383 9510.665659538463 2.0 -1.5785390128148484 -5.556749927454391 -3.5676444701346193 250.0 0.06597828094245005 6.93729369786845e-06 0.0006765432082123454 9510.665659538461 2.3979400086720375 -1.180599004142811 -5.158809918782353 -3.169704461462582 500.0 0.1319565618849001 1.38745873957369e-05 0.0013530864164246904 9510.665659538461 2.6989700043360187 -0.8795690084788297 -4.857779923118372 -2.8686744657986005 1000.0 0.2416961548820222 3.632358677808586e-05 0.002962983505824293 6653.97270260321 3.0 -0.616730258681316 -4.439811273559008 -2.528270766120162 2500.0 0.2416961548820222 3.632358677808586e-05 0.002962983505824293 6653.97270260321 3.3979400086720375 -0.616730258681316 -4.439811273559008 -2.528270766120162 5000.0 0.2416961548820222 3.632358677808586e-05 0.002962983505824293 6653.97270260321 3.6989700043360187 -0.616730258681316 -4.439811273559008 -2.528270766120162 10000.0 0.2416961548820222 3.632358677808586e-05 0.002962983505824293 6653.97270260321 4.0 -0.616730258681316 -4.439811273559008 -2.528270766120162 ==> furosemide_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 2.584762128639262e-10 6.928345875315589e-13 1.3382124656656615e-11 373.07059652554153 -6.0 -9.587579418130106 -12.159370439698634 -10.873474928914371 5e-06 1.2923810643196313e-09 3.4641729376577963e-12 6.691062328328307e-11 373.0705965255414 -5.301029995663981 -8.888609413794088 -11.460400435362613 -10.174504924578352 1e-05 2.5847621286392625e-09 6.9283458753155925e-12 1.3382124656656616e-10 373.0705965255414 -5.0 -8.587579418130106 -11.159370439698632 -9.873474928914371 5e-05 1.2923810643196313e-08 3.464172937657795e-11 6.69106232832832e-10 373.0705965255416 -4.301029995663981 -7.888609413794088 -10.460400435362615 -9.17450492457835 0.0001 2.5847621286392625e-08 6.92834587531559e-11 1.3382124656656643e-09 373.0705965255416 -4.0 -7.587579418130106 -10.159370439698634 -8.87347492891437 0.001 2.584762128639262e-07 6.92834587531559e-10 1.338212465665667e-08 373.07059652554153 -3.0 -6.587579418130106 -9.159370439698634 -7.873474928914369 0.01 2.584762128639262e-06 6.928345875315589e-09 1.3382124656656643e-07 373.07059652554153 -2.0 -5.587579418130106 -8.159370439698634 -6.87347492891437 0.1 2.5847621286392628e-05 6.92834587531559e-08 1.3382124656656643e-06 373.07059652554165 -1.0 -4.587579418130106 -7.159370439698633 -5.87347492891437 1.0 0.00025847621286392624 6.928345875315591e-07 1.3382124656656643e-05 373.0705965255415 0.0 -3.5875794181301064 -6.159370439698633 -4.87347492891437 10.0 0.0025847621286392624 6.928345875315591e-06 0.00013382124656656643 373.0705965255415 1.0 -2.5875794181301064 -5.159370439698633 -3.8734749289143697 25.0 0.006461905321598156 1.7320864688288975e-05 0.00033455311641641635 373.07059652554153 1.3979400086720377 -2.189639409458069 -4.761430431026596 -3.475534920242332 50.0 0.012923810643196311 3.464172937657795e-05 0.000669106232832832 373.07059652554153 1.6989700043360187 -1.8886094137940876 -4.460400435362614 -3.1745049245783514 75.0 0.019385715964794464 5.1962594064866914e-05 0.0010036593492492483 373.07059652554153 1.8750612633917 -1.7125181547384065 -4.284309176306933 -2.99841366552267 100.0 0.025847621286392623 6.92834587531559e-05 0.0013382124656656643 373.07059652554153 2.0 -1.5875794181301064 -4.159370439698633 -2.8734749289143697 250.0 0.06461905321598156 0.00017320864688288973 0.0033455311641641615 373.0705965255416 2.3979400086720375 -1.189639409458069 -3.7614304310265956 -2.4755349202423322 500.0 0.12923810643196312 0.00034641729376577946 0.006691062328328324 373.0705965255416 2.6989700043360187 -0.8886094137940876 -3.4604004353626143 -2.174504924578351 1000.0 0.23493316479408077 0.0008061626242135481 0.013762061496926619 291.4215540856534 3.0 -0.6290556708750933 -3.0935773407328164 -1.861316505803955 2500.0 0.23493316479408077 0.0008061626242135481 0.013762061496926619 291.4215540856534 3.3979400086720375 -0.6290556708750933 -3.0935773407328164 -1.861316505803955 5000.0 0.23493316479408077 0.0008061626242135481 0.013762061496926619 291.4215540856534 3.6989700043360187 -0.6290556708750933 -3.0935773407328164 -1.861316505803955 10000.0 0.23493316479408077 0.0008061626242135481 0.013762061496926619 291.4215540856534 4.0 -0.6290556708750933 -3.0935773407328164 -1.861316505803955 ==> furosemide_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 2.6806478532085025e-10 5.119948103102442e-13 1.1715279719716677e-11 523.5693407876847 -6.0 -9.571760233929544 -12.290734441104338 -10.931247337516941 5e-06 1.3403239266042516e-09 2.5599740515512213e-12 5.857639859858338e-11 523.5693407876848 -5.301029995663981 -8.872790229593525 -11.591764436768319 -10.232277333180923 1e-05 2.6806478532085033e-09 5.1199481031024426e-12 1.1715279719716678e-10 523.5693407876848 -5.0 -8.571760233929544 -11.290734441104338 -9.931247337516941 5e-05 1.3403239266042513e-08 2.5599740515512215e-11 5.85763985985835e-10 523.5693407876847 -4.301029995663981 -7.872790229593525 -10.591764436768319 -9.232277333180921 0.0001 2.6806478532085026e-08 5.119948103102443e-11 1.17152797197167e-09 523.5693407876847 -4.0 -7.571760233929544 -10.290734441104338 -8.93124733751694 0.001 2.680647853208503e-07 5.119948103102441e-10 1.1715279719716676e-08 523.5693407876848 -3.0 -6.571760233929544 -9.290734441104338 -7.931247337516941 0.01 2.680647853208503e-06 5.119948103102442e-09 1.1715279719716678e-07 523.5693407876848 -2.0 -5.571760233929544 -8.290734441104338 -6.931247337516941 0.1 2.6806478532085028e-05 5.119948103102442e-08 1.1715279719716678e-06 523.5693407876848 -1.0 -4.571760233929544 -7.290734441104338 -5.931247337516941 1.0 0.0002680647853208503 5.119948103102442e-07 1.1715279719716677e-05 523.5693407876848 0.0 -3.5717602339295436 -6.290734441104338 -4.931247337516941 10.0 0.002680647853208503 5.119948103102442e-06 0.00011715279719716689 523.5693407876848 1.0 -2.5717602339295436 -5.290734441104338 -3.931247337516941 25.0 0.006701619633021258 1.2799870257756106e-05 0.0002928819929929173 523.5693407876848 1.3979400086720377 -2.173820225257506 -4.8927944324323 -3.533307328844903 50.0 0.013403239266042515 2.559974051551221e-05 0.0005857639859858341 523.5693407876848 1.6989700043360187 -1.8727902295935248 -4.59176443676832 -3.2322773331809223 75.0 0.02010485889906377 3.839961077326832e-05 0.0008786459789787513 523.5693407876847 1.8750612633917 -1.6966989705378437 -4.415673177712638 -3.056186074125241 100.0 0.02680647853208503 5.119948103102442e-05 0.0011715279719716684 523.5693407876848 2.0 -1.5717602339295436 -4.290734441104338 -2.931247337516941 250.0 0.06701619633021258 0.00012799870257756106 0.002928819929929171 523.5693407876848 2.3979400086720375 -1.173820225257506 -3.8927944324323005 -2.5333073288449035 500.0 0.13403239266042516 0.0002559974051551221 0.005857639859858344 523.5693407876848 2.6989700043360187 -0.8727902295935248 -3.5917644367683192 -2.232277333180922 1000.0 0.2374168765760312 0.0005957431783130652 0.011892833330899981 398.5221908009289 3.0 -0.6244884128315734 -3.2249409219365295 -1.9247146673840514 2500.0 0.2374168765760312 0.0005957431783130652 0.011892833330899981 398.5221908009289 3.3979400086720375 -0.6244884128315734 -3.2249409219365295 -1.9247146673840514 5000.0 0.2374168765760312 0.0005957431783130652 0.011892833330899981 398.5221908009289 3.6989700043360187 -0.6244884128315734 -3.2249409219365295 -1.9247146673840514 10000.0 0.2374168765760312 0.0005957431783130652 0.011892833330899981 398.5221908009289 4.0 -0.6244884128315734 -3.2249409219365295 -1.9247146673840514 ==> furosemide_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 2.57342318746242e-10 2.2553599564998772e-13 7.618395899486345e-12 1141.0254846663809 -6.0 -9.589488790211195 -12.646784134652531 -11.118136462431863 5e-06 1.28671159373121e-09 1.1276799782499388e-12 3.809197949743172e-11 1141.0254846663806 -5.301029995663981 -8.890518785875177 -11.947814130316512 -10.419166458095845 1e-05 2.57342318746242e-09 2.2553599564998776e-12 7.618395899486343e-11 1141.0254846663806 -5.0 -8.589488790211195 -11.646784134652531 -10.118136462431863 5e-05 1.2867115937312098e-08 1.1276799782499388e-11 3.8091979497431716e-10 1141.0254846663804 -4.301029995663981 -7.890518785875177 -10.947814130316512 -9.419166458095845 0.0001 2.5734231874624197e-08 2.2553599564998776e-11 7.618395899486344e-10 1141.0254846663804 -4.0 -7.589488790211195 -10.646784134652531 -9.118136462431863 0.001 2.5734231874624195e-07 2.2553599564998772e-10 7.618395899486344e-09 1141.0254846663806 -3.0 -6.589488790211195 -9.646784134652531 -8.118136462431863 0.01 2.5734231874624196e-06 2.2553599564998777e-09 7.618395899486329e-08 1141.0254846663804 -2.0 -5.589488790211195 -8.646784134652531 -7.118136462431864 0.1 2.57342318746242e-05 2.255359956499877e-08 7.618395899486328e-07 1141.0254846663809 -1.0 -4.589488790211195 -7.646784134652532 -6.118136462431864 1.0 0.00025734231874624194 2.2553599564998775e-07 7.618395899486328e-06 1141.0254846663804 0.0 -3.5894887902111954 -6.646784134652532 -5.118136462431864 10.0 0.0025734231874624197 2.255359956499877e-06 7.618395899486335e-05 1141.0254846663809 1.0 -2.5894887902111954 -5.646784134652532 -4.118136462431863 25.0 0.00643355796865605 5.6383998912496916e-06 0.00019045989748715835 1141.025484666381 1.3979400086720377 -2.191548781539158 -5.2488441259804945 -3.720196453759826 50.0 0.0128671159373121 1.1276799782499383e-05 0.00038091979497431675 1141.025484666381 1.6989700043360187 -1.8905187858751766 -4.947814130316513 -3.4191664580958445 75.0 0.01930067390596815 1.6915199673749076e-05 0.000571379692461475 1141.025484666381 1.8750612633917 -1.7144275268194953 -4.771722871260832 -3.2430751990401636 100.0 0.0257342318746242 2.2553599564998766e-05 0.0007618395899486332 1141.025484666381 2.0 -1.5894887902111954 -4.646784134652532 -3.1181364624318637 250.0 0.06433557968656049 5.638399891249693e-05 0.001904598974871583 1141.0254846663809 2.3979400086720375 -1.1915487815391579 -4.2488441259804945 -2.720196453759826 500.0 0.12867115937312099 0.00011276799782499385 0.0038091979497431663 1141.0254846663809 2.6989700043360187 -0.8905187858751766 -3.947814130316513 -2.419166458095845 1000.0 0.238249358694765 0.00027523180838733176 0.008097765237439415 865.6316291737559 3.0 -0.6229682596957204 -3.560301376363795 -2.091634818029758 2500.0 0.238249358694765 0.00027523180838733176 0.008097765237439415 865.6316291737559 3.3979400086720375 -0.6229682596957204 -3.560301376363795 -2.091634818029758 5000.0 0.238249358694765 0.00027523180838733176 0.008097765237439415 865.6316291737559 3.6989700043360187 -0.6229682596957204 -3.560301376363795 -2.091634818029758 10000.0 0.238249358694765 0.00027523180838733176 0.008097765237439415 865.6316291737559 4.0 -0.6229682596957204 -3.560301376363795 -2.091634818029758 ==> haloperidol_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.28693711071411e-09 1.754000338354265e-10 4.751092640259933e-10 7.337154289956473 -6.0 -8.890442675424413 -9.755970327192683 -9.32320650130855 5e-06 6.434685553570552e-09 8.770001691771327e-10 2.3755463201299665e-09 7.337154289956473 -5.301029995663981 -8.191472671088395 -9.057000322856664 -8.62423649697253 1e-05 1.2869371107141103e-08 1.7540003383542654e-09 4.751092640259934e-09 7.337154289956473 -5.0 -7.890442675424414 -8.755970327192683 -8.32320650130855 5e-05 6.434685553570551e-08 8.770001691771325e-09 2.375546320129966e-08 7.337154289956474 -4.301029995663981 -7.191472671088396 -8.057000322856664 -7.62423649697253 0.0001 1.2869371107141103e-07 1.754000338354265e-08 4.7510926402599336e-08 7.337154289956474 -4.0 -6.890442675424414 -7.755970327192683 -7.323206501308548 0.001 1.2869371107141102e-06 1.754000338354265e-07 4.751092640259934e-07 7.337154289956475 -3.0 -5.890442675424414 -6.755970327192683 -6.323206501308548 0.01 1.2869371107141099e-05 1.7540003383542646e-06 4.751092640259933e-06 7.337154289956474 -2.0 -4.890442675424414 -5.755970327192683 -5.323206501308548 0.1 0.00012869371107141102 1.7540003383542654e-05 4.751092640259934e-05 7.337154289956472 -1.0 -3.8904426754244144 -4.755970327192683 -4.323206501308548 1.0 0.00128693711071411 0.0001754000338354265 0.0004751092640259934 7.337154289956472 0.0 -2.8904426754244144 -3.7559703271926828 -3.3232065013085483 10.0 0.012869371107141104 0.001754000338354265 0.004751092640259934 7.337154289956475 1.0 -1.8904426754244141 -2.7559703271926828 -2.3232065013085483 25.0 0.032256980546275946 0.007413111673091724 0.01546365412916012 4.351341510659154 1.3979400086720377 -1.4913762877053716 -2.1299994575010546 -1.8106878726032132 50.0 0.03814882120241931 0.011842742080149734 0.021255273467118686 3.2212827860502538 1.6989700043360187 -1.4185188771899406 -1.9265477289982607 -1.6725333030941005 75.0 0.043824755800076276 0.01630237189669529 0.026729150142395058 2.688244144949248 1.8750612633917 -1.3582804951993661 -1.787749203773589 -1.5730148494864773 100.0 0.04955784225298925 0.02079220407861814 0.032100105448738286 2.383481908200032 2.0 -1.3048876110534482 -1.6820994708203003 -1.4934935409368744 250.0 0.08325563112203871 0.048374062789150206 0.06346190296112958 1.7210799821575473 2.3979400086720375 -1.0795863826562166 -1.3153874360183722 -1.1974869093372946 500.0 0.10751933973587945 0.06808547893455039 0.08555995407107221 1.579181661323647 2.6989700043360187 -0.9685134112354192 -1.1669455032275273 -1.0677294572314733 1000.0 0.10751933973587945 0.06808547893455039 0.08555995407107221 1.579181661323647 3.0 -0.9685134112354192 -1.1669455032275273 -1.0677294572314733 2500.0 0.10751933973587945 0.06808547893455039 0.08555995407107221 1.579181661323647 3.3979400086720375 -0.9685134112354192 -1.1669455032275273 -1.0677294572314733 5000.0 0.10751933973587945 0.06808547893455039 0.08555995407107221 1.579181661323647 3.6989700043360187 -0.9685134112354192 -1.1669455032275273 -1.0677294572314733 10000.0 0.10751933973587945 0.06808547893455039 0.08555995407107221 1.579181661323647 4.0 -0.9685134112354192 -1.1669455032275273 -1.0677294572314733 ==> haloperidol_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 3.078238993078748e-10 1.7583572909262962e-10 2.326508967679604e-10 1.7506333945685992 -6.0 -9.511697664769006 -9.75489287345351 -9.63329526911126 5e-06 1.5391194965393741e-09 8.79178645463148e-10 1.1632544838398018e-09 1.7506333945685997 -5.301029995663981 -8.812727660432987 -9.055922869117492 -8.934325264775241 1e-05 3.0782389930787482e-09 1.758357290926296e-09 2.326508967679608e-09 1.7506333945685997 -5.0 -8.511697664769006 -8.75489287345351 -8.633295269111258 5e-05 1.539119496539374e-08 8.791786454631481e-09 1.163254483839804e-08 1.7506333945685992 -4.301029995663981 -7.812727660432987 -8.055922869117492 -7.934325264775239 0.0001 3.078238993078748e-08 1.7583572909262962e-08 2.3265089676796082e-08 1.7506333945685992 -4.0 -7.511697664769006 -7.75489287345351 -7.633295269111258 0.001 3.0782389930787474e-07 1.758357290926296e-07 2.3265089676796086e-07 1.7506333945685992 -3.0 -6.511697664769006 -6.75489287345351 -6.633295269111258 0.01 3.0782389930787473e-06 1.7583572909262958e-06 2.3265089676796085e-06 1.7506333945685992 -2.0 -5.511697664769006 -5.75489287345351 -5.633295269111258 0.1 3.0782389930787486e-05 1.7583572909262963e-05 2.3265089676796084e-05 1.7506333945685995 -1.0 -4.511697664769006 -4.75489287345351 -4.633295269111258 1.0 0.00030782389930787473 0.0001758357290926296 0.00023265089676796082 1.750633394568599 0.0 -3.5116976647690064 -3.7548928734535103 -3.633295269111258 10.0 0.003078238993078748 0.001758357290926296 0.002326508967679609 1.7506333945685997 1.0 -2.511697664769006 -2.7548928734535103 -2.633295269111258 25.0 0.012952785723867778 0.007433510815781999 0.009812475364192148 1.7424856228591032 1.3979400086720377 -1.887636818887937 -2.128806022335909 -2.008221420611923 50.0 0.020446321959812313 0.011880360853402046 0.015585560080003823 1.7210185963297004 1.6989700043360187 -1.689384804831265 -1.9251703679186964 -1.8072775863749808 75.0 0.027833284292654345 0.016361936120253336 0.021340253503959624 1.7010996796523 1.8750612633917 -1.555435544437798 -1.7861653072300154 -1.6708004258339066 100.0 0.03515339964458783 0.02087889900897197 0.02709177515411975 1.6836807165685268 2.0 -1.4540326684965075 -1.6802924063850508 -1.5671625374407792 250.0 0.07575257700648426 0.04876399766907535 0.06077827316213131 1.5534529699669035 2.3979400086720375 -1.1206025884275161 -1.3119006981633237 -1.2162516432954198 500.0 0.10233960208248162 0.06888045669012062 0.08395950529229287 1.485756729849905 2.6989700043360187 -0.9899562759872985 -1.1619039820924124 -1.0759301290398555 1000.0 0.10233960208248162 0.06888045669012062 0.08395950529229287 1.485756729849905 3.0 -0.9899562759872985 -1.1619039820924124 -1.0759301290398555 2500.0 0.10233960208248162 0.06888045669012062 0.08395950529229287 1.485756729849905 3.3979400086720375 -0.9899562759872985 -1.1619039820924124 -1.0759301290398555 5000.0 0.10233960208248162 0.06888045669012062 0.08395950529229287 1.485756729849905 3.6989700043360187 -0.9899562759872985 -1.1619039820924124 -1.0759301290398555 10000.0 0.10233960208248162 0.06888045669012062 0.08395950529229287 1.485756729849905 4.0 -0.9899562759872985 -1.1619039820924124 -1.0759301290398555 ==> haloperidol_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 3.6071858141755908e-09 9.14755869804229e-11 5.744296647102811e-10 39.43331694551007 -6.0 -8.442831485629346 -10.03869479505217 -9.240763140340759 5e-06 1.8035929070877954e-08 4.573779349021147e-10 2.872148323551411e-09 39.43331694551006 -5.301029995663981 -7.743861481293327 -9.33972479071615 -8.541793136004738 1e-05 3.607185814175591e-08 9.147558698042294e-10 5.7442966471028225e-09 39.43331694551006 -5.0 -7.442831485629346 -9.03869479505217 -8.240763140340757 5e-05 1.8035929070877952e-07 4.573779349021146e-09 2.8721483235514108e-08 39.43331694551006 -4.301029995663981 -6.743861481293327 -8.33972479071615 -7.541793136004738 0.0001 3.6071858141755903e-07 9.147558698042292e-09 5.744296647102822e-08 39.43331694551006 -4.0 -6.442831485629346 -8.03869479505217 -7.240763140340757 0.001 3.60718581417559e-06 9.147558698042291e-08 5.744296647102812e-07 39.43331694551006 -3.0 -5.442831485629346 -7.038694795052169 -6.240763140340758 0.01 3.6071858141755905e-05 9.147558698042293e-07 5.744296647102811e-06 39.43331694551006 -2.0 -4.442831485629346 -6.038694795052169 -5.240763140340758 0.1 0.00036071858141755906 9.147558698042292e-06 5.744296647102817e-05 39.433316945510064 -1.0 -3.4428314856293456 -5.038694795052169 -4.240763140340758 1.0 0.00360718581417559 9.14755869804229e-05 0.0005744296647102823 39.433316945510064 0.0 -2.442831485629346 -4.038694795052169 -3.240763140340757 10.0 0.036071858141755904 0.0009147558698042292 0.0057442966471028195 39.43331694551006 1.0 -1.4428314856293458 -3.038694795052169 -2.2407631403407575 25.0 0.13218340130734746 0.0038626414727938605 0.0225959529098623 34.22098639968746 1.3979400086720377 -0.878823077174266 -2.4131156008412744 -1.6459693390077703 50.0 0.13535501275119954 0.006162302390335742 0.028880763816433966 21.96500661237836 1.6989700043360187 -0.8685256558899815 -2.210256994231999 -1.5393913250609905 75.0 0.1380830198846831 0.008470516158330915 0.03419991887599059 16.301606337044266 1.8750612633917 -0.8598597234762566 -2.072090124747814 -1.4659749241120352 100.0 0.14082879011613014 0.01078731447980429 0.03897646016242432 13.055037041868566 2.0 -0.8513085517959939 -1.9670866602074502 -1.409197606001722 250.0 0.1571182234531271 0.02486871252728367 0.06250862285999696 6.317907422056988 2.3979400086720375 -0.8037734401278084 -1.6043466979134042 -1.2040600690206065 500.0 0.16872831697602703 0.03478013025457287 0.07660543611298797 4.851284792236876 2.6989700043360187 -0.7728120254463129 -1.4586687958601519 -1.1157404106532323 1000.0 0.16872831697602703 0.03478013025457287 0.07660543611298797 4.851284792236876 3.0 -0.7728120254463129 -1.4586687958601519 -1.1157404106532323 2500.0 0.16872831697602703 0.03478013025457287 0.07660543611298797 4.851284792236876 3.3979400086720375 -0.7728120254463129 -1.4586687958601519 -1.1157404106532323 5000.0 0.16872831697602703 0.03478013025457287 0.07660543611298797 4.851284792236876 3.6989700043360187 -0.7728120254463129 -1.4586687958601519 -1.1157404106532323 10000.0 0.16872831697602703 0.03478013025457287 0.07660543611298797 4.851284792236876 4.0 -0.7728120254463129 -1.4586687958601519 -1.1157404106532323 ==> haloperidol_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 2.9434739155386434e-10 1.5544543702581193e-10 2.1390408812712767e-10 1.8935737013945773 -6.0 -9.53113980846327 -9.808422021794453 -9.669780915128863 5e-06 1.471736957769322e-09 7.772271851290598e-10 1.0695204406356427e-09 1.893573701394577 -5.301029995663981 -8.83216980412725 -9.109452017458434 -8.970810910792842 1e-05 2.943473915538644e-09 1.5544543702581196e-09 2.1390408812712855e-09 1.893573701394577 -5.0 -8.53113980846327 -8.808422021794453 -8.669780915128861 5e-05 1.471736957769322e-08 7.772271851290598e-09 1.0695204406356428e-08 1.893573701394577 -4.301029995663981 -7.8321698041272505 -8.109452017458434 -7.970810910792841 0.0001 2.943473915538644e-08 1.5544543702581197e-08 2.1390408812712856e-08 1.893573701394577 -4.0 -7.531139808463269 -7.808422021794452 -7.66978091512886 0.001 2.9434739155386436e-07 1.5544543702581192e-07 2.1390408812712856e-07 1.8935737013945773 -3.0 -6.531139808463269 -6.808422021794452 -6.66978091512886 0.01 2.9434739155386433e-06 1.5544543702581193e-06 2.1390408812712857e-06 1.893573701394577 -2.0 -5.53113980846327 -5.808422021794452 -5.66978091512886 0.1 2.9434739155386437e-05 1.5544543702581193e-05 2.139040881271281e-05 1.8935737013945773 -1.0 -4.531139808463269 -4.808422021794452 -4.669780915128861 1.0 0.0002943473915538644 0.00015544543702581196 0.00021390408812712813 1.8935737013945773 0.0 -3.5311398084632697 -3.808422021794452 -3.669780915128861 10.0 0.002943473915538644 0.0015544543702581193 0.002139040881271282 1.8935737013945773 1.0 -2.5311398084632697 -2.808422021794452 -2.669780915128861 25.0 0.012394916321943802 0.006583009479693042 0.009033042214412488 1.882864723221052 1.3979400086720377 -1.9067564008074733 -2.1815755195129016 -2.0441659601601874 50.0 0.01967051783574236 0.010549061360944632 0.01440505118528921 1.864669960928252 1.6989700043360187 -1.7061842069212731 -1.9767861814940184 -1.8414851942076458 75.0 0.02684200338076246 0.014569698779330988 0.019775740286813365 1.8423169749289074 1.8750612633917 -1.5711850732742576 -1.8365494269415183 -1.703867250107888 100.0 0.03393867427007579 0.018646018728252806 0.025155936795355185 1.8201566116980918 2.0 -1.4693051263211037 -1.729413883905116 -1.5993595051131098 250.0 0.07429105741518621 0.04433492453832775 0.057390664958465634 1.675677994014882 2.3979400086720375 -1.1290634601152667 -1.3532540264033874 -1.241158743259327 500.0 0.10119295884291028 0.06339834341512404 0.08009660389751452 1.5961451576157448 2.6989700043360187 -0.9948497053030939 -1.1979220899900311 -1.0963858976465626 1000.0 0.10119295884291028 0.06339834341512404 0.08009660389751452 1.5961451576157448 3.0 -0.9948497053030939 -1.1979220899900311 -1.0963858976465626 2500.0 0.10119295884291028 0.06339834341512404 0.08009660389751452 1.5961451576157448 3.3979400086720375 -0.9948497053030939 -1.1979220899900311 -1.0963858976465626 5000.0 0.10119295884291028 0.06339834341512404 0.08009660389751452 1.5961451576157448 3.6989700043360187 -0.9948497053030939 -1.1979220899900311 -1.0963858976465626 10000.0 0.10119295884291028 0.06339834341512404 0.08009660389751452 1.5961451576157448 4.0 -0.9948497053030939 -1.1979220899900311 -1.0963858976465626 ==> haloperidol_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 3.926087583060779e-10 1.3187474955121553e-10 2.2754160426881888e-10 2.977133679056599 -6.0 -9.40604001639782 -9.87983835214404 -9.642939184270931 5e-06 1.9630437915303896e-09 6.593737477560779e-10 1.1377080213440943e-09 2.9771336790565983 -5.301029995663981 -8.707070012061802 -9.18086834780802 -8.943969179934912 1e-05 3.926087583060779e-09 1.3187474955121558e-09 2.275416042688189e-09 2.9771336790565983 -5.0 -8.40604001639782 -8.87983835214404 -8.642939184270931 5e-05 1.9630437915303894e-08 6.593737477560776e-09 1.1377080213440943e-08 2.977133679056599 -4.301029995663981 -7.707070012061802 -8.18086834780802 -7.9439691799349115 0.0001 3.926087583060779e-08 1.3187474955121553e-08 2.275416042688189e-08 2.977133679056599 -4.0 -7.406040016397822 -7.87983835214404 -7.64293918427093 0.001 3.9260875830607786e-07 1.3187474955121556e-07 2.2754160426881888e-07 2.9771336790565983 -3.0 -6.406040016397822 -6.87983835214404 -6.64293918427093 0.01 3.926087583060779e-06 1.3187474955121555e-06 2.2754160426881887e-06 2.9771336790565988 -2.0 -5.406040016397822 -5.87983835214404 -5.64293918427093 0.1 3.926087583060779e-05 1.3187474955121555e-05 2.275416042688189e-05 2.9771336790565988 -1.0 -4.406040016397822 -4.87983835214404 -4.64293918427093 1.0 0.0003926087583060779 0.00013187474955121556 0.0002275416042688189 2.9771336790565983 0.0 -3.4060400163978213 -3.8798383521440396 -3.64293918427093 10.0 0.003926087583060779 0.0013187474955121555 0.0022754160426881873 2.977133679056599 1.0 -2.4060400163978213 -2.8798383521440396 -2.6429391842709307 25.0 0.016490806437765702 0.00558154072468584 0.009593962044708157 2.9545258650233883 1.3979400086720377 -1.7827581058528768 -2.2532459021613738 -2.0180020040071254 50.0 0.025868871860721614 0.008937007027252709 0.015204942933347988 2.8945788877458076 1.6989700043360187 -1.5872225104155202 -2.0488079005753224 -1.8180152054954215 75.0 0.03507600897010335 0.012333822167477195 0.020799549441804975 2.843888009233226 1.8750612633917 -1.4549898275313657 -1.908902317644766 -1.6819460725880657 100.0 0.04399734864929482 0.01577400272998288 0.026344151109989954 2.789231712611893 2.0 -1.3565734940064211 -1.8020580883472959 -1.5793157911768585 250.0 0.090866535215889 0.03745526253125031 0.05833892295728663 2.4260018239112777 2.3979400086720375 -1.0415960314864736 -1.426487154527459 -1.2340415930069661 500.0 0.11957862791029343 0.05368721967972751 0.08012392941949564 2.2273201820403963 2.6989700043360187 -0.9223464341438915 -1.270129086426365 -1.0962377602851283 1000.0 0.11957862791029343 0.05368721967972751 0.08012392941949564 2.2273201820403963 3.0 -0.9223464341438915 -1.270129086426365 -1.0962377602851283 2500.0 0.11957862791029343 0.05368721967972751 0.08012392941949564 2.2273201820403963 3.3979400086720375 -0.9223464341438915 -1.270129086426365 -1.0962377602851283 5000.0 0.11957862791029343 0.05368721967972751 0.08012392941949564 2.2273201820403963 3.6989700043360187 -0.9223464341438915 -1.270129086426365 -1.0962377602851283 10000.0 0.11957862791029343 0.05368721967972751 0.08012392941949564 2.2273201820403963 4.0 -0.9223464341438915 -1.270129086426365 -1.0962377602851283 ==> imipramine_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 4.697701798155064e-10 4.345965125320647e-11 1.4288473740724737e-10 10.809340762504313 -6.0 -9.328114554933064 -10.361913763045768 -9.845014158989416 5e-06 2.348850899077532e-09 2.1729825626603244e-10 7.144236870362367e-10 10.80934076250431 -5.301029995663981 -8.629144550597045 -9.66294375870975 -9.146044154653397 1e-05 4.697701798155064e-09 4.345965125320649e-10 1.4288473740724736e-09 10.80934076250431 -5.0 -8.328114554933064 -9.361913763045768 -8.845014158989416 5e-05 2.3488508990775317e-08 2.1729825626603244e-09 7.144236870362367e-09 10.809340762504307 -4.301029995663981 -7.629144550597046 -8.66294375870975 -8.146044154653397 0.0001 4.697701798155063e-08 4.345965125320649e-09 1.4288473740724736e-08 10.809340762504307 -4.0 -7.328114554933065 -8.361913763045768 -7.845014158989416 0.001 4.697701798155064e-07 4.345965125320648e-08 1.4288473740724738e-07 10.809340762504311 -3.0 -6.328114554933065 -7.361913763045768 -6.845014158989416 0.01 4.697701798155064e-06 4.3459651253206495e-07 1.4288473740724737e-06 10.809340762504307 -2.0 -5.328114554933065 -6.361913763045768 -5.845014158989416 0.1 4.6977017981550643e-05 4.345965125320648e-06 1.4288473740724737e-05 10.809340762504313 -1.0 -4.328114554933064 -5.361913763045768 -4.845014158989416 1.0 0.0004697701798155064 4.345965125320648e-05 0.00014288473740724738 10.809340762504313 0.0 -3.3281145549330646 -4.361913763045768 -3.8450141589894162 10.0 0.004697701798155063 0.0004345965125320648 0.0014288473740724722 10.809340762504311 1.0 -2.3281145549330646 -3.3619137630457683 -2.8450141589894167 25.0 0.011744254495387659 0.0010864912813301616 0.0035721184351811814 10.809340762504315 1.3979400086720377 -1.9301745462610271 -2.963973754373731 -2.4470741503173787 50.0 0.023488508990775318 0.0021729825626603232 0.00714423687036236 10.809340762504315 1.6989700043360187 -1.6291445505970459 -2.6629437587097495 -2.146044154653398 75.0 0.03523276348616298 0.0032594738439904853 0.010716355305543544 10.809340762504313 1.8750612633917 -1.4530532915413645 -2.486852499654068 -1.9699528955977164 100.0 0.046977017981550635 0.0043459651253206465 0.014288473740724722 10.809340762504315 2.0 -1.3281145549330646 -2.3619137630457683 -1.8450141589894165 250.0 0.11744254495387658 0.010864912813301618 0.03572118435181181 10.809340762504313 2.3979400086720375 -0.9301745462610271 -1.9639737543737306 -1.4470741503173787 500.0 0.23488508990775317 0.021729825626603236 0.07144236870362361 10.809340762504313 2.6989700043360187 -0.6291445505970459 -1.6629437587097495 -1.1460441546533977 1000.0 0.46977017981550634 0.04345965125320647 0.14288473740724725 10.809340762504313 3.0 -0.3281145549330647 -1.3619137630457683 -0.8450141589894165 2500.0 1.0800055331921983 0.1851404133273269 0.4471606767270615 5.833440218601848 3.3979400086720375 0.03342598051350829 -0.7324987710400448 -0.3495363952632683 5000.0 1.243993296663766 0.2960115185600246 0.6068248057091374 4.20251651934116 3.6989700043360187 0.09481804013793457 -0.5286913891108995 -0.21693667448648252 10000.0 1.6878049682711662 0.5222919981721843 0.9388967085911462 3.2315351837244624 4.0 0.22732226095243288 -0.28208662776493254 -0.02738218340624981 ==> imipramine_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.290341622824279e-10 4.310875666792191e-11 7.45821848948013e-11 2.9932239353691403 -6.0 -9.889295293370784 -10.365434502779317 -10.12736489807505 5e-06 6.451708114121395e-10 2.155437833396096e-10 3.7291092447400644e-10 2.99322393536914 -5.301029995663981 -9.190325289034766 -9.666464498443299 -9.428394893739032 1e-05 1.290341622824279e-09 4.310875666792192e-10 7.45821848948013e-10 2.99322393536914 -5.0 -8.889295293370784 -9.365434502779317 -9.12736489807505 5e-05 6.451708114121395e-09 2.155437833396096e-09 3.729109244740064e-09 2.99322393536914 -4.301029995663981 -8.190325289034766 -8.666464498443299 -8.428394893739032 0.0001 1.290341622824279e-08 4.310875666792192e-09 7.45821848948013e-09 2.99322393536914 -4.0 -7.889295293370783 -8.365434502779317 -8.12736489807505 0.001 1.290341622824279e-07 4.3108756667921915e-08 7.45821848948013e-08 2.9932239353691403 -3.0 -6.889295293370783 -7.365434502779317 -7.127364898075051 0.01 1.290341622824279e-06 4.3108756667921914e-07 7.45821848948013e-07 2.9932239353691403 -2.0 -5.889295293370783 -6.365434502779317 -6.127364898075051 0.1 1.2903416228242792e-05 4.310875666792192e-06 7.45821848948013e-06 2.9932239353691403 -1.0 -4.889295293370783 -5.365434502779317 -5.127364898075051 1.0 0.0001290341622824279 4.310875666792192e-05 7.45821848948013e-05 2.9932239353691403 0.0 -3.8892952933707834 -4.365434502779317 -4.127364898075051 10.0 0.001290341622824279 0.0004310875666792193 0.000745821848948013 2.9932239353691394 1.0 -2.8892952933707834 -3.3654345027793173 -3.127364898075051 25.0 0.003225854057060698 0.001077718916698048 0.0018645546223700338 2.9932239353691403 1.3979400086720377 -2.491355284698746 -2.96749449410728 -2.729424889403013 50.0 0.006451708114121396 0.002155437833396096 0.003729109244740068 2.9932239353691403 1.6989700043360187 -2.1903252890347646 -2.6664644984432986 -2.4283948937390316 75.0 0.009677562171182095 0.003233156750094145 0.0055936638671101 2.99322393536914 1.8750612633917 -2.0142340299790833 -2.4903732393876172 -2.2523036346833503 100.0 0.012903416228242792 0.004310875666792192 0.0074582184894801335 2.9932239353691403 2.0 -1.8892952933707836 -2.3654345027793173 -2.1273648980750504 250.0 0.032258540570606974 0.01077718916698048 0.018645546223700335 2.99322393536914 2.3979400086720375 -1.4913552846987461 -1.9674944941072796 -1.7294248894030129 500.0 0.06451708114121395 0.02155437833396096 0.03729109244740067 2.99322393536914 2.6989700043360187 -1.1903252890347649 -1.6664644984432984 -1.4283948937390316 1000.0 0.1290341622824279 0.04310875666792192 0.07458218489480134 2.99322393536914 3.0 -0.8892952933707836 -1.3654345027793173 -1.1273648980750504 2500.0 0.5447727702271608 0.1836470190317174 0.31630032453645823 2.9664122679447025 3.3979400086720375 -0.2637846082091294 -0.7360161167528446 -0.499900362480987 5000.0 0.8489484436737054 0.2936276443807837 0.49927420493817076 2.891241543227339 3.6989700043360187 -0.07111868349914567 -0.5322030589846706 -0.3016608712419081 10000.0 1.4213024730844417 0.518103124944733 0.8581265948545859 2.7432810277607467 4.0 0.1526865117153844 -0.28558378825300434 -0.06644863826880994 ==> imipramine_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.2481719984760956e-09 2.804539294279154e-11 1.8709749906786987e-10 44.50542023148623 -6.0 -8.90372556461984 -10.552138470730572 -9.727932017675206 5e-06 6.24085999238048e-09 1.4022696471395775e-10 9.354874953393493e-10 44.50542023148622 -5.301029995663981 -8.204755560283822 -9.853168466394553 -9.028962013339187 1e-05 1.248171998476096e-08 2.804539294279155e-10 1.870974990678699e-09 44.50542023148622 -5.0 -7.90372556461984 -9.552138470730572 -8.727932017675206 5e-05 6.240859992380479e-08 1.4022696471395779e-09 9.354874953393494e-09 44.5054202314862 -4.301029995663981 -7.204755560283822 -8.853168466394553 -8.028962013339187 0.0001 1.2481719984760957e-07 2.8045392942791557e-09 1.870974990678699e-08 44.5054202314862 -4.0 -6.90372556461984 -8.552138470730572 -7.727932017675206 0.001 1.2481719984760959e-06 2.8045392942791554e-08 1.8709749906786987e-07 44.50542023148621 -3.0 -5.90372556461984 -7.552138470730572 -6.727932017675206 0.01 1.2481719984760958e-05 2.8045392942791555e-07 1.8709749906786988e-06 44.50542023148621 -2.0 -4.90372556461984 -6.552138470730572 -5.727932017675206 0.1 0.0001248171998476096 2.8045392942791554e-06 1.8709749906786987e-05 44.50542023148621 -1.0 -3.9037255646198408 -5.552138470730572 -4.727932017675206 1.0 0.0012481719984760958 2.804539294279155e-05 0.00018709749906786988 44.50542023148622 0.0 -2.9037255646198408 -4.552138470730572 -3.727932017675206 10.0 0.012481719984760956 0.0002804539294279155 0.0018709749906786971 44.505420231486205 1.0 -1.9037255646198408 -3.552138470730572 -2.7279320176752067 25.0 0.031204299961902392 0.0007011348235697887 0.004677437476696743 44.50542023148621 1.3979400086720377 -1.505785555947803 -3.1541984620585346 -2.3299920090031687 50.0 0.062408599923804785 0.0014022696471395774 0.009354874953393488 44.50542023148621 1.6989700043360187 -1.204755560283822 -2.8531684663945533 -2.0289620133391875 75.0 0.09361289988570717 0.0021034044707093666 0.014032312430090232 44.505420231486205 1.8750612633917 -1.0286643012281407 -2.677077207338872 -1.8528707542835063 100.0 0.12481719984760957 0.002804539294279155 0.018709749906786973 44.50542023148621 2.0 -0.9037255646198408 -2.552138470730572 -1.7279320176752064 250.0 0.3120429996190239 0.007011348235697886 0.046774374766967435 44.50542023148621 2.3979400086720375 -0.5057855559478033 -2.1541984620585346 -1.3299920090031687 500.0 0.6240859992380478 0.014022696471395773 0.09354874953393487 44.50542023148621 2.6989700043360187 -0.20475556028382202 -1.8531684663945533 -1.0289620133391877 1000.0 1.2481719984760955 0.028045392942791545 0.18709749906786974 44.50542023148621 3.0 0.09627443538015916 -1.552138470730572 -0.7279320176752064 2500.0 4.654963691267379 0.11926053448876979 0.7450862083318709 39.03188687877057 3.3979400086720375 0.6679162978321369 -0.9235032486125905 -0.12779347539022687 5000.0 4.761607939971774 0.19015892805104556 0.9515578078416359 25.0401492518594 3.6989700043360187 0.6777536337155549 -0.7208832794436748 -0.02156482286405999 10000.0 4.971438066728407 0.33354376927239704 1.2877081157936652 14.904904617385776 4.0 0.6964820334227462 -0.4768471677258046 0.10981743284847081 ==> imipramine_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.2816575788584965e-10 3.31626012755399e-11 6.519440103218845e-11 3.864767930023097 -6.0 -9.892227990009209 -10.47935141071211 -10.18578970036066 5e-06 6.408287894292482e-10 1.658130063776995e-10 3.259720051609422e-10 3.864767930023097 -5.301029995663981 -9.19325798567319 -9.780381406376092 -9.486819696024641 1e-05 1.2816575788584964e-09 3.31626012755399e-10 6.519440103218845e-10 3.864767930023097 -5.0 -8.892227990009209 -9.47935141071211 -9.18578970036066 5e-05 6.408287894292482e-09 1.658130063776995e-09 3.259720051609422e-09 3.864767930023097 -4.301029995663981 -8.19325798567319 -8.780381406376092 -8.486819696024641 0.0001 1.2816575788584964e-08 3.31626012755399e-09 6.519440103218845e-09 3.864767930023097 -4.0 -7.892227990009209 -8.47935141071211 -8.18578970036066 0.001 1.2816575788584966e-07 3.3162601275539896e-08 6.519440103218845e-08 3.8647679300230977 -3.0 -6.892227990009209 -7.479351410712111 -7.18578970036066 0.01 1.2816575788584965e-06 3.3162601275539896e-07 6.519440103218845e-07 3.8647679300230973 -2.0 -5.892227990009209 -6.479351410712111 -6.18578970036066 0.1 1.2816575788584965e-05 3.3162601275539894e-06 6.519440103218846e-06 3.8647679300230977 -1.0 -4.892227990009209 -5.479351410712111 -5.18578970036066 1.0 0.00012816575788584966 3.31626012755399e-05 6.519440103218845e-05 3.864767930023097 0.0 -3.892227990009209 -4.479351410712111 -4.18578970036066 10.0 0.0012816575788584966 0.000331626012755399 0.0006519440103218845 3.864767930023097 1.0 -2.892227990009209 -3.4793514107121104 -3.18578970036066 25.0 0.0032041439471462412 0.0008290650318884975 0.001629860025804711 3.864767930023097 1.3979400086720377 -2.4942879813371714 -3.081411402040073 -2.7878496916886224 50.0 0.0064082878942924824 0.001658130063776995 0.0032597200516094223 3.864767930023097 1.6989700043360187 -2.19325798567319 -2.7803814063760917 -2.486819696024641 75.0 0.009612431841438724 0.0024871950956654927 0.004889580077414134 3.8647679300230964 1.8750612633917 -2.017166726617509 -2.6042901473204108 -2.31072843696896 100.0 0.012816575788584965 0.00331626012755399 0.006519440103218845 3.864767930023097 2.0 -1.892227990009209 -2.4793514107121104 -2.18578970036066 250.0 0.032041439471462416 0.008290650318884974 0.016298600258047115 3.8647679300230977 2.3979400086720375 -1.4942879813371712 -2.081411402040073 -1.7878496916886222 500.0 0.06408287894292483 0.016581300637769948 0.03259720051609422 3.8647679300230977 2.6989700043360187 -1.19325798567319 -1.7803814063760919 -1.4868196960246411 1000.0 0.12816575788584966 0.033162601275539896 0.06519440103218846 3.8647679300230977 3.0 -0.8922279900092088 -1.4793514107121106 -1.1857897003606597 2500.0 0.5399930863844141 0.14152481449543944 0.27644605509823067 3.815536436557669 3.3979400086720375 -0.26761180048132754 -0.84916740569728 -0.5583896030893039 5000.0 0.8550421597237501 0.2269062084567607 0.44047062845733104 3.7682625148914206 3.6989700043360187 -0.06801247090460509 -0.6441536210757304 -0.35608304599016766 10000.0 1.4571497627507524 0.4028976208437979 0.7662128768334444 3.616675024536034 4.0 0.16350418992629565 -0.3948052971622822 -0.11565055361799312 ==> imipramine_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 2.0036887761120892e-10 3.3114463469179455e-11 8.14561715158333e-11 6.050796438169616 -6.0 -9.698169734558148 -10.479982277134152 -10.08907600584615 5e-06 1.0018443880560445e-09 1.6557231734589727e-10 4.072808575791664e-10 6.050796438169616 -5.301029995663981 -8.999199730222129 -9.781012272798133 -9.390106001510132 1e-05 2.003688776112089e-09 3.3114463469179455e-10 8.145617151583329e-10 6.050796438169616 -5.0 -8.698169734558148 -9.479982277134152 -9.08907600584615 5e-05 1.0018443880560445e-08 1.6557231734589726e-09 4.072808575791664e-09 6.050796438169616 -4.301029995663981 -7.99919973022213 -8.781012272798133 -8.390106001510132 0.0001 2.003688776112089e-08 3.311446346917945e-09 8.145617151583328e-09 6.050796438169616 -4.0 -7.698169734558149 -8.479982277134152 -8.08907600584615 0.001 2.0036887761120888e-07 3.311446346917945e-08 8.145617151583328e-08 6.050796438169616 -3.0 -6.698169734558149 -7.479982277134152 -7.089076005846151 0.01 2.0036887761120886e-06 3.311446346917946e-07 8.145617151583329e-07 6.0507964381696135 -2.0 -5.698169734558149 -6.479982277134152 -6.089076005846151 0.1 2.0036887761120888e-05 3.3114463469179452e-06 8.14561715158333e-06 6.050796438169615 -1.0 -4.698169734558149 -5.479982277134152 -5.089076005846151 1.0 0.0002003688776112089 3.311446346917945e-05 8.145617151583337e-05 6.050796438169615 0.0 -3.6981697345581486 -4.479982277134152 -4.08907600584615 10.0 0.002003688776112089 0.0003311446346917945 0.0008145617151583338 6.050796438169616 1.0 -2.6981697345581486 -3.4799822771341518 -3.08907600584615 25.0 0.005009221940280222 0.0008278615867294863 0.002036404287895834 6.050796438169615 1.3979400086720377 -2.3002297258861106 -3.082042268462114 -2.6911359971741127 50.0 0.010018443880560444 0.0016557231734589727 0.0040728085757916685 6.050796438169615 1.6989700043360187 -1.9991997302221296 -2.7810122727981326 -2.3901060015101314 75.0 0.015027665820840665 0.0024835847601884587 0.006109212863687504 6.050796438169616 1.8750612633917 -1.8231084711664485 -2.6049210137424517 -2.21401474245445 100.0 0.02003688776112089 0.0033114463469179453 0.008145617151583339 6.050796438169615 2.0 -1.6981697345581483 -2.4799822771341518 -2.08907600584615 250.0 0.050092219402802216 0.008278615867294864 0.02036404287895835 6.050796438169614 2.3979400086720375 -1.3002297258861109 -2.082042268462114 -1.6911359971741122 500.0 0.10018443880560443 0.016557231734589728 0.04072808575791669 6.050796438169614 2.6989700043360187 -0.9991997302221296 -1.7810122727981328 -1.3901060015101312 1000.0 0.20036887761120886 0.033114463469179456 0.08145617151583337 6.050796438169614 3.0 -0.6981697345581485 -1.4799822771341515 -1.0890760058461502 2500.0 0.8463817533169458 0.14093070441314434 0.34537107101983705 6.005658999870899 3.3979400086720375 -0.07243370792607065 -0.8509943773343701 -0.4617140426302204 5000.0 1.300121262813484 0.2249940430134653 0.5408507551332233 5.778469711465539 3.6989700043360187 0.11398386101044801 -0.6478289802025424 -0.2669225595960471 10000.0 2.1429285619903404 0.3957519054426359 0.9209061090225894 5.414828160065441 4.0 0.3310076933700955 -0.40257698544544174 -0.03578464603767302 ==> ketoprofen_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.2234239774110023e-09 3.6876697811568516e-13 2.1240488768013905e-11 3317.6071883182676 -6.0 -8.912423012186062 -12.433247975536592 -10.672835493861328 5e-06 6.117119887055013e-09 1.843834890578426e-12 1.0620244384006994e-10 3317.6071883182676 -5.301029995663981 -8.213453007850044 -11.734277971200571 -9.973865489525307 1e-05 1.2234239774110025e-08 3.687669781156852e-12 2.124048876801395e-10 3317.6071883182676 -5.0 -7.912423012186062 -11.433247975536592 -9.672835493861326 5e-05 6.117119887055013e-08 1.8438348905784264e-11 1.0620244384006994e-09 3317.607188318267 -4.301029995663981 -7.213453007850044 -10.734277971200571 -8.973865489525307 0.0001 1.2234239774110026e-07 3.687669781156853e-11 2.124048876801399e-09 3317.607188318267 -4.0 -6.912423012186062 -10.43324797553659 -8.672835493861326 0.001 1.2234239774110025e-06 3.6876697811568525e-10 2.1240488768013992e-08 3317.607188318267 -3.0 -5.912423012186062 -9.43324797553659 -7.672835493861326 0.01 1.2234239774110025e-05 3.687669781156852e-09 2.124048876801399e-07 3317.6071883182676 -2.0 -4.912423012186062 -8.433247975536592 -6.672835493861326 0.1 0.00012234239774110026 3.6876697811568524e-08 2.124048876801397e-06 3317.6071883182676 -1.0 -3.9124230121860624 -7.433247975536591 -5.672835493861326 1.0 0.0012234239774110024 3.687669781156852e-07 2.124048876801397e-05 3317.607188318267 0.0 -2.9124230121860624 -6.433247975536591 -4.672835493861326 10.0 0.012234239774110027 3.687669781156852e-06 0.0002124048876801397 3317.607188318268 1.0 -1.9124230121860621 -5.433247975536591 -3.6728354938613266 25.0 0.03058559943527506 9.21917445289213e-06 0.0005310122192003491 3317.607188318267 1.3979400086720377 -1.5144830035140247 -5.035307966864553 -3.274895485189289 50.0 0.06117119887055012 1.843834890578426e-05 0.0010620244384006983 3317.607188318267 1.6989700043360187 -1.2134530078500434 -4.734277971200572 -2.973865489525308 75.0 0.09175679830582519 2.7657523358676397e-05 0.0015930366576010478 3317.6071883182667 1.8750612633917 -1.0373617487943623 -4.558186712144891 -2.7977742304696265 100.0 0.12234239774110024 3.687669781156852e-05 0.002124048876801397 3317.607188318267 2.0 -0.9124230121860623 -4.433247975536591 -2.6728354938613266 250.0 0.3058559943527506 9.21917445289213e-05 0.0053101221920034926 3317.6071883182676 2.3979400086720375 -0.5144830035140247 -4.035307966864553 -2.274895485189289 500.0 0.6117119887055013 0.0001843834890578426 0.010620244384006985 3317.6071883182676 2.6989700043360187 -0.21345300785004342 -3.734277971200572 -1.9738654895253078 1000.0 1.2234239774110025 0.0003687669781156852 0.02124048876801397 3317.6071883182676 3.0 0.08757698781393776 -3.433247975536591 -1.6728354938613266 2500.0 4.426407922257004 0.001523351844377662 0.08211562989064934 2905.70293303799 3.3979400086720375 0.646051434494507 -2.8171997772785464 -1.0855741713920197 5000.0 6.4670147383088326 0.0026857562715853233 0.13179083955968895 2407.89337689661 3.6989700043360187 0.8107038507041764 -2.5709334014619025 -0.880114775378863 10000.0 9.433843007468749 0.005622784672428299 0.23031384644543224 1677.7884192735014 4.0 0.9746886446935146 -2.250048547713571 -0.6376799515100284 ==> ketoprofen_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.162066541808413e-09 3.64293798295177e-13 2.0575073131999522e-11 3189.9157966637226 -6.0 -8.93476900282968 -12.438548222085311 -10.686658612457496 5e-06 5.8103327090420665e-09 1.8214689914758854e-12 1.028753656599976e-10 3189.9157966637226 -5.301029995663981 -8.235798998493662 -11.739578217749292 -9.987688608121477 1e-05 1.1620665418084133e-08 3.642937982951771e-12 2.057507313199952e-10 3189.9157966637226 -5.0 -7.934769002829682 -11.438548222085311 -9.686658612457496 5e-05 5.810332709042065e-08 1.8214689914758854e-11 1.028753656599976e-09 3189.9157966637217 -4.301029995663981 -7.235798998493663 -10.739578217749292 -8.987688608121477 0.0001 1.162066541808413e-07 3.642937982951771e-11 2.057507313199952e-09 3189.9157966637217 -4.0 -6.934769002829682 -10.438548222085311 -8.686658612457496 0.001 1.162066541808413e-06 3.6429379829517715e-10 2.0575073131999524e-08 3189.9157966637213 -3.0 -5.934769002829682 -9.438548222085311 -7.686658612457496 0.01 1.162066541808413e-05 3.6429379829517708e-09 2.0575073131999523e-07 3189.915796663722 -2.0 -4.934769002829682 -8.438548222085311 -6.686658612457496 0.1 0.00011620665418084131 3.6429379829517715e-08 2.05750731319995e-06 3189.9157966637217 -1.0 -3.9347690028296816 -7.438548222085311 -5.686658612457496 1.0 0.0011620665418084132 3.6429379829517706e-07 2.0575073131999502e-05 3189.9157966637226 0.0 -2.9347690028296816 -6.438548222085311 -4.686658612457496 10.0 0.011620665418084132 3.6429379829517713e-06 0.00020575073131999514 3189.915796663722 1.0 -1.9347690028296816 -5.438548222085311 -3.686658612457496 25.0 0.02905166354521033 9.107344957379428e-06 0.0005143768282999877 3189.915796663722 1.3979400086720377 -1.5368289941576438 -5.0406082134132735 -3.2887186037854583 50.0 0.05810332709042066 1.8214689914758856e-05 0.0010287536565999754 3189.915796663722 1.6989700043360187 -1.2357989984936626 -4.739578217749292 -2.987688608121477 75.0 0.08715499063563098 2.7322034872138282e-05 0.0015431304848999628 3189.9157966637217 1.8750612633917 -1.0597077394379815 -4.563486958693611 -2.811597349065796 100.0 0.11620665418084132 3.642937982951771e-05 0.0020575073131999513 3189.915796663722 2.0 -0.9347690028296815 -4.438548222085311 -2.686658612457496 250.0 0.29051663545210327 9.107344957379428e-05 0.005143768282999878 3189.9157966637217 2.3979400086720375 -0.536828994157644 -4.0406082134132735 -2.2887186037854583 500.0 0.5810332709042065 0.00018214689914758855 0.010287536565999752 3189.9157966637217 2.6989700043360187 -0.23579899849366276 -3.7395782177492918 -1.9876886081214773 1000.0 1.162066541808413 0.0003642937982951771 0.020575073131999508 3189.9157966637217 3.0 0.06523099717031845 -3.4385482220853105 -1.686658612457496 2500.0 4.321552426628079 0.0015048734362413814 0.08064359522092923 2871.70490391652 3.3979400086720375 0.6356397859828999 -2.822500023826484 -1.093430118921792 5000.0 6.605426226327591 0.002653177783087018 0.13238342083324744 2489.628199223824 3.6989700043360187 0.8199008464425658 -2.5762336480098402 -0.8781664007836372 10000.0 9.830281266133085 0.0055545797397182186 0.23367302188441516 1769.7614809346082 4.0 0.9925659441375276 -2.255348794261509 -0.6313914250619908 ==> ketoprofen_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 2.0346526477255563e-09 3.629909343364086e-12 8.593954070437802e-11 560.5243699667452 -6.0 -8.691509722090863 -11.440104221291262 -10.065806971691064 5e-06 1.0173263238627785e-08 1.814954671682043e-11 4.2969770352189177e-10 560.5243699667454 -5.301029995663981 -7.992539717754844 -10.741134216955244 -9.366836967355043 1e-05 2.034652647725557e-08 3.629909343364086e-11 8.593954070437837e-10 560.5243699667454 -5.0 -7.691509722090863 -10.440104221291262 -9.065806971691062 5e-05 1.0173263238627784e-07 1.814954671682043e-10 4.296977035218909e-09 560.5243699667454 -4.301029995663981 -6.992539717754844 -9.741134216955244 -8.366836967355043 0.0001 2.0346526477255568e-07 3.629909343364086e-10 8.593954070437802e-09 560.5243699667454 -4.0 -6.691509722090863 -9.440104221291262 -8.065806971691064 0.001 2.034652647725556e-06 3.629909343364086e-09 8.59395407043782e-08 560.5243699667452 -3.0 -5.6915097220908635 -8.440104221291262 -7.065806971691063 0.01 2.0346526477255564e-05 3.6299093433640866e-08 8.593954070437819e-07 560.5243699667452 -2.0 -4.6915097220908635 -7.440104221291263 -6.065806971691063 0.1 0.00020346526477255566 3.6299093433640855e-07 8.59395407043782e-06 560.5243699667454 -1.0 -3.691509722090863 -6.440104221291263 -5.065806971691063 1.0 0.0020346526477255564 3.629909343364087e-06 8.59395407043782e-05 560.5243699667452 0.0 -2.691509722090863 -5.4401042212912625 -4.065806971691063 10.0 0.020346526477255565 3.6299093433640876e-05 0.0008593954070437819 560.5243699667451 1.0 -1.691509722090863 -4.4401042212912625 -3.065806971691063 25.0 0.05086631619313892 9.074773358410216e-05 0.002148488517609455 560.5243699667453 1.3979400086720377 -1.2935697134188253 -4.042164212619225 -2.6678669630190255 50.0 0.10173263238627785 0.00018149546716820432 0.00429697703521891 560.5243699667453 1.6989700043360187 -0.9925397177548442 -3.741134216955244 -2.3668369673550442 75.0 0.15259894857941678 0.00027224320075230636 0.006445465552828363 560.5243699667457 1.8750612633917 -0.8164484586991629 -3.5650429578995633 -2.190745708299363 100.0 0.2034652647725557 0.00036299093433640864 0.00859395407043782 560.5243699667453 2.0 -0.6915097220908629 -3.440104221291263 -2.065806971691063 250.0 0.5086631619313892 0.0009074773358410215 0.021484885176094544 560.5243699667453 2.3979400086720375 -0.29356971341882543 -3.0421642126192254 -1.6678669630190255 500.0 1.0173263238627783 0.001814954671682043 0.042969770352189095 560.5243699667453 2.6989700043360187 0.0074602822451557815 -2.741134216955244 -1.3668369673550442 1000.0 2.0346526477255567 0.003629909343364086 0.0859395407043782 560.5243699667453 3.0 0.30849027790913697 -2.440104221291263 -1.065806971691063 2500.0 7.387677540897284 0.014654575476623782 0.3290338555833389 504.1208837937151 3.3979400086720375 0.8685079309932712 -1.8340267579713767 -0.48275941348905294 5000.0 10.06997806986047 0.024960706576343708 0.5013519400899962 403.4332136817074 3.6989700043360187 1.0030285247592827 -1.602743125004685 -0.2998573001227012 10000.0 12.077412435044563 0.0483838201236095 0.764428774194065 249.6167604002652 4.0 1.0819738974013795 -1.3152998450872655 -0.116662973842943 ==> ketoprofen_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.3378815982711545e-09 2.7249581418483094e-12 6.037939511156126e-11 490.9732658732453 -6.0 -8.873582319671927 -11.564640164544741 -10.219111242108333 5e-06 6.689407991355774e-09 1.3624790709241551e-11 3.018969755578063e-10 490.9732658732452 -5.301029995663981 -8.174612315335908 -10.865670160208722 -9.520141237772314 1e-05 1.3378815982711547e-08 2.7249581418483102e-11 6.037939511156127e-10 490.9732658732452 -5.0 -7.873582319671926 -10.564640164544741 -9.219111242108333 5e-05 6.689407991355772e-08 1.3624790709241547e-10 3.0189697555780568e-09 490.9732658732453 -4.301029995663981 -7.174612315335907 -9.865670160208722 -8.520141237772314 0.0001 1.3378815982711544e-07 2.7249581418483094e-10 6.037939511156102e-09 490.9732658732453 -4.0 -6.873582319671927 -9.564640164544741 -8.219111242108335 0.001 1.3378815982711544e-06 2.7249581418483103e-09 6.037939511156114e-08 490.9732658732451 -3.0 -5.873582319671927 -8.564640164544741 -7.219111242108334 0.01 1.3378815982711546e-05 2.72495814184831e-08 6.037939511156114e-07 490.9732658732452 -2.0 -4.873582319671926 -7.564640164544742 -6.219111242108334 0.1 0.00013378815982711546 2.72495814184831e-07 6.037939511156114e-06 490.9732658732452 -1.0 -3.8735823196719266 -6.564640164544742 -5.219111242108334 1.0 0.0013378815982711548 2.724958141848309e-06 6.0379395111561144e-05 490.9732658732455 0.0 -2.8735823196719266 -5.564640164544742 -4.219111242108334 10.0 0.013378815982711546 2.72495814184831e-05 0.0006037939511156114 490.9732658732452 1.0 -1.8735823196719266 -4.564640164544742 -3.219111242108334 25.0 0.03344703995677886 6.812395354620776e-05 0.0015094848777890283 490.9732658732451 1.3979400086720377 -1.475642310999889 -4.166700155872704 -2.8211712334362966 50.0 0.06689407991355772 0.00013624790709241552 0.0030189697555780565 490.9732658732451 1.6989700043360187 -1.1746123153359078 -3.865670160208723 -2.5201412377723154 75.0 0.10034111987033659 0.0002043718606386233 0.004528454633367086 490.9732658732451 1.8750612633917 -0.9985210562802265 -3.6895789011530415 -2.344049978716634 100.0 0.13378815982711545 0.00027249581418483103 0.006037939511156114 490.9732658732451 2.0 -0.8735823196719266 -3.5646401645447416 -2.219111242108334 250.0 0.3344703995677886 0.0006812395354620774 0.015094848777890283 490.9732658732453 2.3979400086720375 -0.47564231099988896 -3.166700155872704 -1.8211712334362966 500.0 0.6689407991355772 0.0013624790709241548 0.030189697555780565 490.9732658732453 2.6989700043360187 -0.1746123153359078 -2.865670160208723 -1.5201412377723154 1000.0 1.3378815982711545 0.0027249581418483096 0.06037939511156113 490.9732658732453 3.0 0.1264176803280734 -2.5646401645447416 -1.219111242108334 2500.0 4.89496558959098 0.011001144755806082 0.23205651256920165 444.95056634970285 3.3979400086720375 0.6897496431660648 -1.9585621207270436 -0.6344062387804894 5000.0 7.6667413101492805 0.018737968945220524 0.3790239577924019 409.1554070007587 3.6989700043360187 0.8846108096146437 -1.7272774851497685 -0.4213333377675626 10000.0 11.27019978024925 0.03632191108188833 0.6398087169563499 310.2865307621178 4.0 1.0519316145989757 -1.439831309091381 -0.19394984724620268 ==> ketoprofen_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.5209559397974446e-09 1.6776749881705271e-12 5.051405485909397e-11 906.5855726060613 -6.0 -8.817883366735956 -11.77529217015548 -10.296587768445718 5e-06 7.604779698987223e-09 8.388374940852636e-12 2.5257027429547034e-10 906.5855726060614 -5.301029995663981 -8.118913362399937 -11.07632216581946 -9.5976177641097 1e-05 1.5209559397974447e-08 1.6776749881705273e-11 5.051405485909408e-10 906.5855726060614 -5.0 -7.8178833667359555 -10.77529217015548 -9.296587768445717 5e-05 7.604779698987224e-08 8.388374940852637e-11 2.5257027429547035e-09 906.5855726060613 -4.301029995663981 -7.118913362399937 -10.07632216581946 -8.597617764109698 0.0001 1.5209559397974447e-07 1.6776749881705274e-10 5.051405485909418e-09 906.5855726060613 -4.0 -6.8178833667359555 -9.77529217015548 -8.296587768445717 0.001 1.5209559397974445e-06 1.6776749881705273e-09 5.0514054859094176e-08 906.5855726060613 -3.0 -5.8178833667359555 -8.77529217015548 -7.2965877684457165 0.01 1.5209559397974446e-05 1.677674988170527e-08 5.051405485909418e-07 906.5855726060615 -2.0 -4.8178833667359555 -7.7752921701554785 -6.2965877684457165 0.1 0.00015209559397974447 1.6776749881705272e-07 5.0514054859094135e-06 906.5855726060614 -1.0 -3.8178833667359555 -6.7752921701554785 -5.2965877684457165 1.0 0.0015209559397974443 1.6776749881705274e-06 5.051405485909413e-05 906.5855726060611 0.0 -2.8178833667359555 -5.7752921701554785 -4.2965877684457165 10.0 0.015209559397974446 1.6776749881705274e-05 0.0005051405485909413 906.5855726060612 1.0 -1.8178833667359553 -4.7752921701554785 -3.296587768445717 25.0 0.03802389849493611 4.194187470426319e-05 0.001262851371477353 906.5855726060612 1.3979400086720377 -1.4199433580639178 -4.377352161483441 -2.8986477597736795 50.0 0.07604779698987223 8.388374940852637e-05 0.0025257027429547068 906.5855726060612 1.6989700043360187 -1.1189133623999366 -4.07632216581946 -2.5976177641096982 75.0 0.11407169548480833 0.00012582562411278956 0.00378855411443206 906.5855726060611 1.8750612633917 -0.9428221033442554 -3.9002309067637784 -2.421526505054017 100.0 0.15209559397974445 0.00016776749881705275 0.005051405485909414 906.5855726060612 2.0 -0.8178833667359554 -3.7752921701554785 -2.296587768445717 250.0 0.3802389849493612 0.0004194187470426318 0.012628513714773533 906.5855726060614 2.3979400086720375 -0.41994335806391775 -3.377352161483441 -1.8986477597736793 500.0 0.7604779698987224 0.0008388374940852636 0.025257027429547066 906.5855726060614 2.6989700043360187 -0.11891336239993654 -3.0763221658194597 -1.5976177641096982 1000.0 1.5209559397974448 0.0016776749881705273 0.05051405485909412 906.5855726060614 3.0 0.18211663326404468 -2.7752921701554785 -1.296587768445717 2500.0 5.6824119005721165 0.006828044010926631 0.19697654313475915 832.2166482053707 3.3979400086720375 0.7545327112000028 -2.16570368825429 -0.7055854885271438 5000.0 8.32950045964025 0.011771144518646262 0.3131257793260655 707.6202697576075 3.6989700043360187 0.9206189564935782 -1.9291813082723661 -0.5042811758893939 10000.0 11.081840352187127 0.023434198537704575 0.5096018514255017 472.89180102988985 4.0 1.0446118893121001 -1.6301498949965294 -0.2927690028422145 ==> nifedipine_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 4.808755353066676e-10 9.386111667022706e-13 2.1245120551147038e-11 512.3266719659667 -6.0 -9.317967317231835 -12.027514283270413 -10.672740800251125 5e-06 2.404377676533338e-09 4.6930558335113535e-12 1.0622560275573517e-10 512.3266719659669 -5.301029995663981 -8.618997312895816 -11.328544278934395 -9.973770795915106 1e-05 4.808755353066676e-09 9.386111667022707e-12 2.1245120551147037e-10 512.3266719659669 -5.0 -8.317967317231835 -11.027514283270413 -9.672740800251125 5e-05 2.4043776765333385e-08 4.693055833511353e-11 1.0622560275573517e-09 512.326671965967 -4.301029995663981 -7.618997312895816 -10.328544278934395 -8.973770795915106 0.0001 4.808755353066677e-08 9.386111667022706e-11 2.1245120551147038e-09 512.326671965967 -4.0 -7.317967317231835 -10.027514283270415 -8.672740800251125 0.001 4.808755353066676e-07 9.386111667022703e-10 2.1245120551147035e-08 512.3266719659671 -3.0 -6.317967317231835 -9.027514283270415 -7.672740800251124 0.01 4.8087553530666765e-06 9.386111667022703e-09 2.1245120551147037e-07 512.3266719659671 -2.0 -5.317967317231835 -8.027514283270415 -6.672740800251124 0.1 4.808755353066675e-05 9.386111667022705e-08 2.1245120551147035e-06 512.3266719659667 -1.0 -4.317967317231835 -7.027514283270414 -5.672740800251124 1.0 0.0004808755353066676 9.386111667022704e-07 2.1245120551147035e-05 512.326671965967 0.0 -3.3179673172318345 -6.027514283270414 -4.672740800251124 10.0 0.0036241754311604583 1.3228231905903825e-05 0.00021895532208893555 273.9727770831543 1.0 -2.440790788108657 -4.878498200016914 -3.6596444940627855 25.0 0.006320001993769556 4.4892987723782237e-05 0.0005326572743524451 140.7792689730363 1.3979400086720377 -2.1992827847108143 -4.347821490415373 -3.273552137563094 50.0 0.007941838807060753 0.00012624258363301492 0.0010012982821318982 62.90934943273615 1.6989700043360187 -2.1000789319176243 -3.8987941259369383 -2.9994365289272813 75.0 0.007941838807060753 0.00012624258363301492 0.0010012982821318982 62.90934943273615 1.8750612633917 -2.1000789319176243 -3.8987941259369383 -2.9994365289272813 100.0 0.007941838807060753 0.00012624258363301492 0.0010012982821318982 62.90934943273615 2.0 -2.1000789319176243 -3.8987941259369383 -2.9994365289272813 250.0 0.007941838807060753 0.00012624258363301492 0.0010012982821318982 62.90934943273615 2.3979400086720375 -2.1000789319176243 -3.8987941259369383 -2.9994365289272813 500.0 0.007941838807060753 0.00012624258363301492 0.0010012982821318982 62.90934943273615 2.6989700043360187 -2.1000789319176243 -3.8987941259369383 -2.9994365289272813 1000.0 0.007941838807060753 0.00012624258363301492 0.0010012982821318982 62.90934943273615 3.0 -2.1000789319176243 -3.8987941259369383 -2.9994365289272813 2500.0 0.007941838807060753 0.00012624258363301492 0.0010012982821318982 62.90934943273615 3.3979400086720375 -2.1000789319176243 -3.8987941259369383 -2.9994365289272813 5000.0 0.007941838807060753 0.00012624258363301492 0.0010012982821318982 62.90934943273615 3.6989700043360187 -2.1000789319176243 -3.8987941259369383 -2.9994365289272813 10000.0 0.007941838807060753 0.00012624258363301492 0.0010012982821318982 62.90934943273615 4.0 -2.1000789319176243 -3.8987941259369383 -2.9994365289272813 ==> nifedipine_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 4.5446446690174953e-10 9.304839632579492e-13 2.056384930703998e-11 488.41730201400867 -6.0 -9.342500067187364 -12.031291107464538 -10.686895587325953 5e-06 2.2723223345087482e-09 4.652419816289747e-12 1.0281924653519988e-10 488.4173020140087 -5.301029995663981 -8.643530062851346 -11.33232110312852 -9.987925582989934 1e-05 4.5446446690174964e-09 9.304839632579494e-12 2.056384930703998e-10 488.4173020140087 -5.0 -8.342500067187364 -11.031291107464538 -9.686895587325953 5e-05 2.2723223345087482e-08 4.652419816289748e-11 1.028192465352001e-09 488.4173020140086 -4.301029995663981 -7.643530062851345 -10.33232110312852 -8.987925582989932 0.0001 4.5446446690174964e-08 9.304839632579495e-11 2.0563849307040024e-09 488.4173020140086 -4.0 -7.3425000671873635 -10.031291107464538 -8.686895587325951 0.001 4.544644669017496e-07 9.304839632579493e-10 2.0563849307040063e-08 488.41730201400867 -3.0 -6.3425000671873635 -9.031291107464538 -7.68689558732595 0.01 4.544644669017496e-06 9.304839632579493e-09 2.0563849307040063e-07 488.4173020140087 -2.0 -5.3425000671873635 -8.031291107464538 -6.68689558732595 0.1 4.544644669017496e-05 9.304839632579495e-08 2.0563849307040064e-06 488.41730201400856 -1.0 -4.3425000671873635 -7.031291107464539 -5.68689558732595 1.0 0.00045446446690174954 9.304839632579495e-07 2.0563849307040043e-05 488.41730201400856 0.0 -3.342500067187364 -6.031291107464539 -4.686895587325951 10.0 0.0038956958811236 1.3113691896446342e-05 0.00022602423654845052 297.0708715658699 1.0 -2.40941495382244 -4.882275024211145 -3.6458449890167928 25.0 0.006420641963056672 4.450427037477966e-05 0.0005345521358142068 144.27024438300234 1.3979400086720377 -2.1924215471531436 -4.351598314609603 -3.2720099308813735 50.0 0.007951140091860273 0.0001251494801233317 0.0009975374924703797 63.533145195845975 1.6989700043360187 -2.099570594600885 -3.9025709501311656 -3.0010707723660253 75.0 0.007951140091860273 0.0001251494801233317 0.0009975374924703797 63.533145195845975 1.8750612633917 -2.099570594600885 -3.9025709501311656 -3.0010707723660253 100.0 0.007951140091860273 0.0001251494801233317 0.0009975374924703797 63.533145195845975 2.0 -2.099570594600885 -3.9025709501311656 -3.0010707723660253 250.0 0.007951140091860273 0.0001251494801233317 0.0009975374924703797 63.533145195845975 2.3979400086720375 -2.099570594600885 -3.9025709501311656 -3.0010707723660253 500.0 0.007951140091860273 0.0001251494801233317 0.0009975374924703797 63.533145195845975 2.6989700043360187 -2.099570594600885 -3.9025709501311656 -3.0010707723660253 1000.0 0.007951140091860273 0.0001251494801233317 0.0009975374924703797 63.533145195845975 3.0 -2.099570594600885 -3.9025709501311656 -3.0010707723660253 2500.0 0.007951140091860273 0.0001251494801233317 0.0009975374924703797 63.533145195845975 3.3979400086720375 -2.099570594600885 -3.9025709501311656 -3.0010707723660253 5000.0 0.007951140091860273 0.0001251494801233317 0.0009975374924703797 63.533145195845975 3.6989700043360187 -2.099570594600885 -3.9025709501311656 -3.0010707723660253 10000.0 0.007951140091860273 0.0001251494801233317 0.0009975374924703797 63.533145195845975 4.0 -2.099570594600885 -3.9025709501311656 -3.0010707723660253 ==> nifedipine_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.6601583255003624e-09 4.272070570528785e-12 8.421587454149272e-11 388.6074207090808 -6.0 -8.779850492313974 -11.369361581789871 -10.074606037051923 5e-06 8.300791627501812e-09 2.1360352852643924e-11 4.2107937270746357e-10 388.6074207090808 -5.301029995663981 -8.080880487977955 -10.670391577453852 -9.375636032715905 1e-05 1.6601583255003624e-08 4.272070570528785e-11 8.421587454149272e-10 388.6074207090808 -5.0 -7.779850492313974 -10.369361581789871 -9.074606037051923 5e-05 8.300791627501814e-08 2.1360352852643926e-10 4.210793727074636e-09 388.6074207090809 -4.301029995663981 -7.080880487977955 -9.670391577453852 -8.375636032715905 0.0001 1.6601583255003627e-07 4.272070570528785e-10 8.421587454149273e-09 388.6074207090809 -4.0 -6.779850492313974 -9.369361581789871 -8.074606037051923 0.001 1.6601583255003626e-06 4.272070570528784e-09 8.421587454149273e-08 388.60742070908094 -3.0 -5.779850492313974 -8.369361581789871 -7.074606037051923 0.01 1.6601583255003623e-05 4.272070570528784e-08 8.421587454149274e-07 388.6074207090809 -2.0 -4.779850492313974 -7.369361581789871 -6.074606037051923 0.1 0.00016601583255003625 4.272070570528786e-07 8.421587454149273e-06 388.6074207090807 -1.0 -3.779850492313974 -6.369361581789871 -5.074606037051923 1.0 0.0016601583255003622 4.272070570528785e-06 8.421587454149272e-05 388.60742070908077 0.0 -2.7798504923139746 -5.369361581789871 -4.074606037051923 10.0 0.005466902635800192 5.469351517242896e-05 0.0005468126939431176 99.95522537845696 1.0 -2.2622586607181465 -4.262064163461536 -3.2621614120898417 25.0 0.006567888330873408 0.00015429890456677576 0.0010066866318625054 42.56600751193947 1.3979400086720377 -2.182574239825546 -3.8116371571662317 -2.997105698495889 50.0 0.007660659657343405 0.00033624844646805305 0.0016049563572577935 22.782736211306908 1.6989700043360187 -2.115733831776112 -3.4733397135082287 -2.7945367726421706 75.0 0.007660659657343405 0.00033624844646805305 0.0016049563572577935 22.782736211306908 1.8750612633917 -2.115733831776112 -3.4733397135082287 -2.7945367726421706 100.0 0.007660659657343405 0.00033624844646805305 0.0016049563572577935 22.782736211306908 2.0 -2.115733831776112 -3.4733397135082287 -2.7945367726421706 250.0 0.007660659657343405 0.00033624844646805305 0.0016049563572577935 22.782736211306908 2.3979400086720375 -2.115733831776112 -3.4733397135082287 -2.7945367726421706 500.0 0.007660659657343405 0.00033624844646805305 0.0016049563572577935 22.782736211306908 2.6989700043360187 -2.115733831776112 -3.4733397135082287 -2.7945367726421706 1000.0 0.007660659657343405 0.00033624844646805305 0.0016049563572577935 22.782736211306908 3.0 -2.115733831776112 -3.4733397135082287 -2.7945367726421706 2500.0 0.007660659657343405 0.00033624844646805305 0.0016049563572577935 22.782736211306908 3.3979400086720375 -2.115733831776112 -3.4733397135082287 -2.7945367726421706 5000.0 0.007660659657343405 0.00033624844646805305 0.0016049563572577935 22.782736211306908 3.6989700043360187 -2.115733831776112 -3.4733397135082287 -2.7945367726421706 10000.0 0.007660659657343405 0.00033624844646805305 0.0016049563572577935 22.782736211306908 4.0 -2.115733831776112 -3.4733397135082287 -2.7945367726421706 ==> nifedipine_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 5.852836242755544e-10 3.3889178808805587e-12 4.453625646250481e-11 172.70516573375255 -6.0 -9.232633626895995 -11.469938954713086 -10.351286290804541 5e-06 2.926418121377772e-09 1.69445894044028e-11 2.2268128231252404e-10 172.7051657337525 -5.301029995663981 -8.533663622559976 -10.770968950377068 -9.652316286468523 1e-05 5.852836242755544e-09 3.38891788088056e-11 4.453625646250482e-10 172.7051657337525 -5.0 -8.232633626895995 -10.469938954713086 -9.351286290804541 5e-05 2.9264181213777723e-08 1.694458940440279e-10 2.2268128231252404e-09 172.70516573375264 -4.301029995663981 -7.533663622559975 -9.770968950377068 -8.652316286468523 0.0001 5.852836242755545e-08 3.388917880880558e-10 4.453625646250482e-09 172.70516573375264 -4.0 -7.232633626895994 -9.469938954713086 -8.351286290804541 0.001 5.852836242755544e-07 3.3889178808805586e-09 4.453625646250481e-08 172.70516573375255 -3.0 -6.232633626895994 -8.469938954713086 -7.35128629080454 0.01 5.852836242755543e-06 3.388917880880558e-08 4.4536256462504816e-07 172.70516573375258 -2.0 -5.232633626895994 -7.469938954713087 -6.35128629080454 0.1 5.852836242755543e-05 3.388917880880559e-07 4.453625646250486e-06 172.7051657337525 -1.0 -4.2326336268959945 -6.469938954713086 -5.35128629080454 1.0 0.0005852836242755543 3.388917880880559e-06 4.453625646250486e-05 172.70516573375252 0.0 -3.232633626895994 -5.469938954713087 -4.35128629080454 10.0 0.004981010324489057 4.3386967677592435e-05 0.00046487733215372086 114.80429702999369 1.0 -2.3026825580740855 -4.3626407017239295 -3.3326616298990075 25.0 0.007017798419318405 0.0001224026787803784 0.000926821086113861 57.33369963177133 1.3979400086720377 -2.153799110705252 -3.912209077559688 -3.0330040941324703 50.0 0.007929677453141685 0.00026675886798825904 0.001454411145760406 29.726012533126724 1.6989700043360187 -2.1007444776470408 -3.573881134211458 -2.8373128059292494 75.0 0.007929677453141685 0.00026675886798825904 0.001454411145760406 29.726012533126724 1.8750612633917 -2.1007444776470408 -3.573881134211458 -2.8373128059292494 100.0 0.007929677453141685 0.00026675886798825904 0.001454411145760406 29.726012533126724 2.0 -2.1007444776470408 -3.573881134211458 -2.8373128059292494 250.0 0.007929677453141685 0.00026675886798825904 0.001454411145760406 29.726012533126724 2.3979400086720375 -2.1007444776470408 -3.573881134211458 -2.8373128059292494 500.0 0.007929677453141685 0.00026675886798825904 0.001454411145760406 29.726012533126724 2.6989700043360187 -2.1007444776470408 -3.573881134211458 -2.8373128059292494 1000.0 0.007929677453141685 0.00026675886798825904 0.001454411145760406 29.726012533126724 3.0 -2.1007444776470408 -3.573881134211458 -2.8373128059292494 2500.0 0.007929677453141685 0.00026675886798825904 0.001454411145760406 29.726012533126724 3.3979400086720375 -2.1007444776470408 -3.573881134211458 -2.8373128059292494 5000.0 0.007929677453141685 0.00026675886798825904 0.001454411145760406 29.726012533126724 3.6989700043360187 -2.1007444776470408 -3.573881134211458 -2.8373128059292494 10000.0 0.007929677453141685 0.00026675886798825904 0.001454411145760406 29.726012533126724 4.0 -2.1007444776470408 -3.573881134211458 -2.8373128059292494 ==> nifedipine_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 7.27214532950989e-10 2.5808836953124312e-12 4.332269764323836e-11 281.7695870107604 -6.0 -9.138337450581808 -11.588231566018747 -10.363284508300278 5e-06 3.636072664754946e-09 1.2904418476562157e-11 2.1661348821619178e-10 281.7695870107605 -5.301029995663981 -8.43936744624579 -10.889261561682728 -9.66431450396426 1e-05 7.272145329509892e-09 2.5808836953124314e-11 4.332269764323836e-10 281.7695870107605 -5.0 -8.138337450581808 -10.588231566018747 -9.363284508300278 5e-05 3.6360726647549464e-08 1.2904418476562159e-10 2.1661348821619177e-09 281.7695870107605 -4.301029995663981 -7.439367446245789 -9.889261561682728 -8.66431450396426 0.0001 7.272145329509893e-08 2.5808836953124317e-10 4.332269764323835e-09 281.7695870107605 -4.0 -7.138337450581807 -9.588231566018747 -8.363284508300278 0.001 7.272145329509893e-07 2.580883695312432e-09 4.332269764323836e-08 281.76958701076046 -3.0 -6.138337450581807 -8.588231566018747 -7.363284508300278 0.01 7.2721453295098925e-06 2.5808836953124317e-08 4.3322697643238354e-07 281.76958701076046 -2.0 -5.138337450581807 -7.588231566018748 -6.363284508300278 0.1 7.272145329509891e-05 2.5808836953124315e-07 4.33226976432384e-06 281.76958701076046 -1.0 -4.138337450581807 -6.588231566018748 -5.363284508300278 1.0 0.0007272145329509892 2.5808836953124315e-06 4.33226976432384e-05 281.7695870107605 0.0 -3.138337450581808 -5.588231566018748 -4.363284508300278 10.0 0.0048293247754733724 3.4171310920155604e-05 0.00040623190228871895 141.32688051557437 1.0 -2.3161135870094607 -4.4663383599642135 -3.3912259734868373 25.0 0.006569202772167307 0.00010271450774684643 0.0008214331555472932 63.95593880815728 1.3979400086720377 -2.1824873325188743 -3.988368210838771 -3.0854277716788228 50.0 0.007751719591107842 0.00024398428608661692 0.0013752446220146029 31.771388704745938 1.6989700043360187 -2.1106019457402034 -3.6126381436843564 -2.86162004471228 75.0 0.007751719591107842 0.00024398428608661692 0.0013752446220146029 31.771388704745938 1.8750612633917 -2.1106019457402034 -3.6126381436843564 -2.86162004471228 100.0 0.007751719591107842 0.00024398428608661692 0.0013752446220146029 31.771388704745938 2.0 -2.1106019457402034 -3.6126381436843564 -2.86162004471228 250.0 0.007751719591107842 0.00024398428608661692 0.0013752446220146029 31.771388704745938 2.3979400086720375 -2.1106019457402034 -3.6126381436843564 -2.86162004471228 500.0 0.007751719591107842 0.00024398428608661692 0.0013752446220146029 31.771388704745938 2.6989700043360187 -2.1106019457402034 -3.6126381436843564 -2.86162004471228 1000.0 0.007751719591107842 0.00024398428608661692 0.0013752446220146029 31.771388704745938 3.0 -2.1106019457402034 -3.6126381436843564 -2.86162004471228 2500.0 0.007751719591107842 0.00024398428608661692 0.0013752446220146029 31.771388704745938 3.3979400086720375 -2.1106019457402034 -3.6126381436843564 -2.86162004471228 5000.0 0.007751719591107842 0.00024398428608661692 0.0013752446220146029 31.771388704745938 3.6989700043360187 -2.1106019457402034 -3.6126381436843564 -2.86162004471228 10000.0 0.007751719591107842 0.00024398428608661692 0.0013752446220146029 31.771388704745938 4.0 -2.1106019457402034 -3.6126381436843564 -2.86162004471228 ==> phenytoin_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.386156166252151e-08 3.3286258702773002e-09 6.792639601238472e-09 4.164349555261594 -6.0 -7.85818783875671 -8.47773501577907 -8.167961427267889 5e-06 6.930780831260756e-08 1.6643129351386503e-08 3.3963198006192355e-08 4.164349555261594 -5.301029995663981 -7.159217834420692 -7.77876501144305 -7.468991422931871 1e-05 1.3861561662521512e-07 3.3286258702773006e-08 6.792639601238472e-08 4.164349555261594 -5.0 -6.85818783875671 -7.477735015779069 -7.1679614272678895 5e-05 6.930780831260754e-07 1.6643129351386505e-07 3.396319800619236e-07 4.164349555261592 -4.301029995663981 -6.159217834420692 -6.77876501144305 -6.468991422931871 0.0001 1.3861561662521509e-06 3.328625870277301e-07 6.792639601238473e-07 4.164349555261592 -4.0 -5.85818783875671 -6.477735015779069 -6.1679614272678895 0.001 1.386156166252151e-05 3.3286258702773e-06 6.792639601238472e-06 4.164349555261594 -3.0 -4.85818783875671 -5.477735015779069 -5.1679614272678895 0.01 0.00013861561662521508 3.3286258702773e-05 6.792639601238472e-05 4.164349555261593 -2.0 -3.8581878387567103 -4.477735015779069 -4.1679614272678895 0.1 0.001386156166252151 0.0003328625870277301 0.0006792639601238472 4.164349555261593 -1.0 -2.8581878387567103 -3.4777350157790687 -3.1679614272678895 1.0 0.013861561662521511 0.0033286258702773016 0.006792639601238472 4.164349555261592 0.0 -1.8581878387567101 -2.4777350157790687 -2.1679614272678895 10.0 0.10271414749205424 0.03842695852861028 0.06282509280517401 2.6729710449391875 1.0 -0.9883697340602332 -1.4153639883307085 -1.2018668611954708 25.0 0.16776443640520625 0.09006036024696319 0.12291836957624203 1.8627999704327545 1.3979400086720377 -0.7753000977976888 -1.0454663201650545 -0.9103832089813716 50.0 0.2509681767727462 0.16096446858804755 0.20098994802411455 1.5591526438983434 1.6989700043360187 -0.6003813443683552 -0.7932699798635259 -0.6968256621159405 75.0 0.2509681767727462 0.16096446858804755 0.20098994802411455 1.5591526438983434 1.8750612633917 -0.6003813443683552 -0.7932699798635259 -0.6968256621159405 100.0 0.2509681767727462 0.16096446858804755 0.20098994802411455 1.5591526438983434 2.0 -0.6003813443683552 -0.7932699798635259 -0.6968256621159405 250.0 0.2509681767727462 0.16096446858804755 0.20098994802411455 1.5591526438983434 2.3979400086720375 -0.6003813443683552 -0.7932699798635259 -0.6968256621159405 500.0 0.2509681767727462 0.16096446858804755 0.20098994802411455 1.5591526438983434 2.6989700043360187 -0.6003813443683552 -0.7932699798635259 -0.6968256621159405 1000.0 0.2509681767727462 0.16096446858804755 0.20098994802411455 1.5591526438983434 3.0 -0.6003813443683552 -0.7932699798635259 -0.6968256621159405 2500.0 0.2509681767727462 0.16096446858804755 0.20098994802411455 1.5591526438983434 3.3979400086720375 -0.6003813443683552 -0.7932699798635259 -0.6968256621159405 5000.0 0.2509681767727462 0.16096446858804755 0.20098994802411455 1.5591526438983434 3.6989700043360187 -0.6003813443683552 -0.7932699798635259 -0.6968256621159405 10000.0 0.2509681767727462 0.16096446858804755 0.20098994802411455 1.5591526438983434 4.0 -0.6003813443683552 -0.7932699798635259 -0.6968256621159405 ==> phenytoin_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 5.629161542018578e-09 3.3558697629323487e-09 4.346347088017917e-09 1.6774076289241433 -6.0 -8.249556288060246 -8.474194901936706 -8.361875594998475 5e-06 2.8145807710092893e-08 1.6779348814661746e-08 2.1731735440089584e-08 1.6774076289241433 -5.301029995663981 -7.550586283724227 -7.775224897600686 -7.662905590662456 1e-05 5.6291615420185786e-08 3.355869762932349e-08 4.3463470880179174e-08 1.6774076289241433 -5.0 -7.249556288060246 -7.474194901936705 -7.361875594998475 5e-05 2.8145807710092894e-07 1.6779348814661745e-07 2.1731735440089582e-07 1.6774076289241433 -4.301029995663981 -6.550586283724227 -6.775224897600686 -6.662905590662456 0.0001 5.629161542018579e-07 3.355869762932349e-07 4.346347088017917e-07 1.6774076289241433 -4.0 -6.249556288060246 -6.474194901936705 -6.361875594998475 0.001 5.629161542018578e-06 3.355869762932349e-06 4.346347088017917e-06 1.677407628924143 -3.0 -5.249556288060246 -5.474194901936705 -5.361875594998475 0.01 5.629161542018578e-05 3.35586976293235e-05 4.346347088017913e-05 1.6774076289241429 -2.0 -4.249556288060246 -4.474194901936705 -4.361875594998475 0.1 0.0005629161542018578 0.00033558697629323486 0.0004346347088017913 1.6774076289241433 -1.0 -3.249556288060246 -3.4741949019367047 -3.3618755949984753 1.0 0.005629161542018577 0.003355869762932348 0.004346347088017913 1.6774076289241435 0.0 -2.249556288060246 -2.4741949019367047 -2.3618755949984753 10.0 0.06323096725911106 0.038807942820546566 0.049536489196141405 1.6293305613106066 1.0 -1.1990701746302186 -1.411079378269114 -1.3050747764496662 25.0 0.14059678526436595 0.09127394354160706 0.11328205083044353 1.5403824991989654 1.3979400086720377 -0.8520246093155396 -1.0396531851293245 -0.945838897222432 50.0 0.23568007068509164 0.16414379671508164 0.19668609918428337 1.4358146661745712 1.6989700043360187 -0.6276771402479623 -0.7847755253824973 -0.7062263328152297 75.0 0.23568007068509164 0.16414379671508164 0.19668609918428337 1.4358146661745712 1.8750612633917 -0.6276771402479623 -0.7847755253824973 -0.7062263328152297 100.0 0.23568007068509164 0.16414379671508164 0.19668609918428337 1.4358146661745712 2.0 -0.6276771402479623 -0.7847755253824973 -0.7062263328152297 250.0 0.23568007068509164 0.16414379671508164 0.19668609918428337 1.4358146661745712 2.3979400086720375 -0.6276771402479623 -0.7847755253824973 -0.7062263328152297 500.0 0.23568007068509164 0.16414379671508164 0.19668609918428337 1.4358146661745712 2.6989700043360187 -0.6276771402479623 -0.7847755253824973 -0.7062263328152297 1000.0 0.23568007068509164 0.16414379671508164 0.19668609918428337 1.4358146661745712 3.0 -0.6276771402479623 -0.7847755253824973 -0.7062263328152297 2500.0 0.23568007068509164 0.16414379671508164 0.19668609918428337 1.4358146661745712 3.3979400086720375 -0.6276771402479623 -0.7847755253824973 -0.7062263328152297 5000.0 0.23568007068509164 0.16414379671508164 0.19668609918428337 1.4358146661745712 3.6989700043360187 -0.6276771402479623 -0.7847755253824973 -0.7062263328152297 10000.0 0.23568007068509164 0.16414379671508164 0.19668609918428337 1.4358146661745712 4.0 -0.6276771402479623 -0.7847755253824973 -0.7062263328152297 ==> phenytoin_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 2.981722780648137e-08 1.6662293149800611e-09 7.048570001255416e-09 17.8950325374861 -6.0 -7.525532736614529 -8.778265228993405 -8.151898982803967 5e-06 1.4908613903240686e-07 8.331146574900307e-09 3.524285000627715e-08 17.8950325374861 -5.301029995663981 -6.826562732278509 -8.079295224657386 -7.4529289784679476 1e-05 2.981722780648137e-07 1.6662293149800614e-08 7.048570001255431e-08 17.8950325374861 -5.0 -6.525532736614528 -7.778265228993405 -7.151898982803966 5e-05 1.4908613903240686e-06 8.331146574900307e-08 3.524285000627715e-07 17.8950325374861 -4.301029995663981 -5.826562732278509 -7.079295224657386 -6.4529289784679476 0.0001 2.981722780648137e-06 1.6662293149800615e-07 7.048570001255417e-07 17.8950325374861 -4.0 -5.525532736614528 -6.778265228993405 -6.151898982803967 0.001 2.9817227806481367e-05 1.6662293149800614e-06 7.048570001255431e-06 17.895032537486095 -3.0 -4.525532736614529 -5.778265228993405 -5.151898982803966 0.01 0.0002981722780648137 1.6662293149800618e-05 7.048570001255431e-05 17.895032537486095 -2.0 -3.525532736614528 -4.778265228993405 -4.151898982803966 0.1 0.002981722780648137 0.00016662293149800615 0.0007048570001255423 17.895032537486095 -1.0 -2.525532736614528 -3.7782652289934053 -3.1518989828039667 1.0 0.029817227806481366 0.001666229314980061 0.007048570001255424 17.8950325374861 0.0 -1.5255327366145282 -2.7782652289934053 -2.1518989828039667 10.0 0.2380345140971167 0.019163071803343208 0.0675386739973251 12.421521796708447 1.0 -0.6233600673334933 -1.7175348731117783 -1.1704474702226357 25.0 0.34795525090973617 0.04462195152298138 0.12460514571341375 7.797849243113691 1.3979400086720377 -0.4584766052850274 -1.3504514399435181 -0.9044640226142728 50.0 0.397094336585999 0.07906221446029513 0.17718678731816 5.0225552028449565 1.6989700043360187 -0.40110630685953375 -1.1020310256315773 -0.7515686662455556 75.0 0.397094336585999 0.07906221446029513 0.17718678731816 5.0225552028449565 1.8750612633917 -0.40110630685953375 -1.1020310256315773 -0.7515686662455556 100.0 0.397094336585999 0.07906221446029513 0.17718678731816 5.0225552028449565 2.0 -0.40110630685953375 -1.1020310256315773 -0.7515686662455556 250.0 0.397094336585999 0.07906221446029513 0.17718678731816 5.0225552028449565 2.3979400086720375 -0.40110630685953375 -1.1020310256315773 -0.7515686662455556 500.0 0.397094336585999 0.07906221446029513 0.17718678731816 5.0225552028449565 2.6989700043360187 -0.40110630685953375 -1.1020310256315773 -0.7515686662455556 1000.0 0.397094336585999 0.07906221446029513 0.17718678731816 5.0225552028449565 3.0 -0.40110630685953375 -1.1020310256315773 -0.7515686662455556 2500.0 0.397094336585999 0.07906221446029513 0.17718678731816 5.0225552028449565 3.3979400086720375 -0.40110630685953375 -1.1020310256315773 -0.7515686662455556 5000.0 0.397094336585999 0.07906221446029513 0.17718678731816 5.0225552028449565 3.6989700043360187 -0.40110630685953375 -1.1020310256315773 -0.7515686662455556 10000.0 0.397094336585999 0.07906221446029513 0.17718678731816 5.0225552028449565 4.0 -0.40110630685953375 -1.1020310256315773 -0.7515686662455556 ==> phenytoin_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 5.370762914336054e-09 3.0217097726322826e-09 4.028509250919047e-09 1.777392045715051 -6.0 -8.269964018592326 -8.519747250849809 -8.394855634721067 5e-06 2.6853814571680275e-08 1.5108548863161412e-08 2.0142546254595232e-08 1.7773920457150514 -5.301029995663981 -7.570994014256306 -7.82077724651379 -7.695885630385048 1e-05 5.370762914336055e-08 3.0217097726322824e-08 4.028509250919048e-08 1.7773920457150514 -5.0 -7.269964018592325 -7.519747250849809 -7.3948556347210666 5e-05 2.685381457168028e-07 1.5108548863161415e-07 2.0142546254595236e-07 1.7773920457150512 -4.301029995663981 -6.570994014256306 -6.82077724651379 -6.695885630385048 0.0001 5.370762914336056e-07 3.021709772632283e-07 4.0285092509190477e-07 1.7773920457150512 -4.0 -6.269964018592325 -6.519747250849809 -6.3948556347210666 0.001 5.370762914336054e-06 3.0217097726322835e-06 4.028509250919048e-06 1.7773920457150503 -3.0 -5.269964018592325 -5.519747250849809 -5.3948556347210666 0.01 5.370762914336054e-05 3.0217097726322825e-05 4.028509250919039e-05 1.777392045715051 -2.0 -4.269964018592325 -4.519747250849809 -4.394855634721067 0.1 0.0005370762914336055 0.0003021709772632284 0.0004028509250919039 1.7773920457150503 -1.0 -3.269964018592325 -3.519747250849809 -3.3948556347210674 1.0 0.005370762914336054 0.003021709772632283 0.004028509250919042 1.7773920457150507 0.0 -2.2699640185923253 -2.519747250849809 -2.394855634721067 10.0 0.060594876243574854 0.03518776458763188 0.046175732159605215 1.7220439250316375 1.0 -1.217564097173961 -1.4536083221984262 -1.3355862096861937 25.0 0.13628437582457556 0.08374381837326722 0.106831521641168 1.6273962481280932 1.3979400086720377 -0.8655539305344683 -1.0770472409533454 -0.9713005857439068 50.0 0.23109426231526678 0.1529301020256214 0.1879927368634476 1.5111103651559064 1.6989700043360187 -0.6362108371939865 -0.8155070217367335 -0.7258589294653601 75.0 0.23109426231526678 0.1529301020256214 0.1879927368634476 1.5111103651559064 1.8750612633917 -0.6362108371939865 -0.8155070217367335 -0.7258589294653601 100.0 0.23109426231526678 0.1529301020256214 0.1879927368634476 1.5111103651559064 2.0 -0.6362108371939865 -0.8155070217367335 -0.7258589294653601 250.0 0.23109426231526678 0.1529301020256214 0.1879927368634476 1.5111103651559064 2.3979400086720375 -0.6362108371939865 -0.8155070217367335 -0.7258589294653601 500.0 0.23109426231526678 0.1529301020256214 0.1879927368634476 1.5111103651559064 2.6989700043360187 -0.6362108371939865 -0.8155070217367335 -0.7258589294653601 1000.0 0.23109426231526678 0.1529301020256214 0.1879927368634476 1.5111103651559064 3.0 -0.6362108371939865 -0.8155070217367335 -0.7258589294653601 2500.0 0.23109426231526678 0.1529301020256214 0.1879927368634476 1.5111103651559064 3.3979400086720375 -0.6362108371939865 -0.8155070217367335 -0.7258589294653601 5000.0 0.23109426231526678 0.1529301020256214 0.1879927368634476 1.5111103651559064 3.6989700043360187 -0.6362108371939865 -0.8155070217367335 -0.7258589294653601 10000.0 0.23109426231526678 0.1529301020256214 0.1879927368634476 1.5111103651559064 4.0 -0.6362108371939865 -0.8155070217367335 -0.7258589294653601 ==> phenytoin_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 6.8471336196890315e-09 2.580032070533545e-09 4.203073200650458e-09 2.653894770491384 -6.0 -8.164491196927862 -8.5883748955991 -8.376433046263482 5e-06 3.423566809844517e-08 1.290016035266773e-08 2.1015366003252336e-08 2.6538947704913833 -5.301029995663981 -7.465521192591844 -7.889404891263082 -7.677463041927463 1e-05 6.847133619689034e-08 2.580032070533546e-08 4.203073200650459e-08 2.6538947704913833 -5.0 -7.164491196927862 -7.588374895599101 -7.376433046263482 5e-05 3.4235668098445163e-07 1.290016035266773e-07 2.1015366003252334e-07 2.653894770491383 -4.301029995663981 -6.465521192591844 -6.889404891263082 -6.677463041927463 0.0001 6.847133619689033e-07 2.580032070533546e-07 4.2030732006504673e-07 2.653894770491383 -4.0 -6.164491196927862 -6.588374895599101 -6.3764330462634815 0.001 6.8471336196890335e-06 2.5800320705335464e-06 4.203073200650468e-06 2.653894770491383 -3.0 -5.164491196927862 -5.588374895599101 -5.3764330462634815 0.01 6.847133619689034e-05 2.580032070533546e-05 4.2030732006504676e-05 2.6538947704913833 -2.0 -4.164491196927862 -4.588374895599101 -4.3764330462634815 0.1 0.0006847133619689032 0.0002580032070533546 0.00042030732006504676 2.653894770491383 -1.0 -3.1644911969278624 -3.588374895599101 -3.3764330462634815 1.0 0.006847133619689034 0.0025800320705335455 0.0042030732006504675 2.653894770491384 0.0 -2.1644911969278624 -2.588374895599101 -2.3764330462634815 10.0 0.07603953567621594 0.030053806803512845 0.04780457629392626 2.530113278938362 1.0 -1.1189605437512673 -1.5221005097162204 -1.3205305267337437 25.0 0.16465711561933966 0.07170582474965369 0.10865944172681835 2.2962864759481745 1.3979400086720377 -0.7834194966104954 -1.144445564640613 -0.9639325306255543 50.0 0.26659801049272047 0.13199669969324418 0.18759013174957787 2.0197323956756885 1.6989700043360187 -0.5741430958646095 -0.8794369273012026 -0.726790011582906 75.0 0.26659801049272047 0.13199669969324418 0.18759013174957787 2.0197323956756885 1.8750612633917 -0.5741430958646095 -0.8794369273012026 -0.726790011582906 100.0 0.26659801049272047 0.13199669969324418 0.18759013174957787 2.0197323956756885 2.0 -0.5741430958646095 -0.8794369273012026 -0.726790011582906 250.0 0.26659801049272047 0.13199669969324418 0.18759013174957787 2.0197323956756885 2.3979400086720375 -0.5741430958646095 -0.8794369273012026 -0.726790011582906 500.0 0.26659801049272047 0.13199669969324418 0.18759013174957787 2.0197323956756885 2.6989700043360187 -0.5741430958646095 -0.8794369273012026 -0.726790011582906 1000.0 0.26659801049272047 0.13199669969324418 0.18759013174957787 2.0197323956756885 3.0 -0.5741430958646095 -0.8794369273012026 -0.726790011582906 2500.0 0.26659801049272047 0.13199669969324418 0.18759013174957787 2.0197323956756885 3.3979400086720375 -0.5741430958646095 -0.8794369273012026 -0.726790011582906 5000.0 0.26659801049272047 0.13199669969324418 0.18759013174957787 2.0197323956756885 3.6989700043360187 -0.5741430958646095 -0.8794369273012026 -0.726790011582906 10000.0 0.26659801049272047 0.13199669969324418 0.18759013174957787 2.0197323956756885 4.0 -0.5741430958646095 -0.8794369273012026 -0.726790011582906 ==> prazosin_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 4.926487348042641e-10 8.420535026936754e-12 6.440780952179173e-11 58.50563333901139 -6.0 -9.307462628206096 -11.074660313267062 -10.191061470736578 5e-06 2.4632436740213206e-09 4.210267513468378e-11 3.220390476089586e-10 58.505633339011375 -5.301029995663981 -8.608492623870077 -10.375690308931043 -9.49209146640056 1e-05 4.926487348042641e-09 8.420535026936756e-11 6.440780952179159e-10 58.505633339011375 -5.0 -8.307462628206096 -10.074660313267062 -9.19106147073658 5e-05 2.4632436740213204e-08 4.2102675134683775e-10 3.2203904760895727e-09 58.505633339011375 -4.301029995663981 -7.608492623870077 -9.375690308931043 -8.492091466400561 0.0001 4.926487348042641e-08 8.420535026936755e-10 6.440780952179146e-09 58.505633339011375 -4.0 -7.307462628206096 -9.074660313267062 -8.19106147073658 0.001 4.926487348042642e-07 8.420535026936753e-09 6.440780952179147e-08 58.505633339011396 -3.0 -6.307462628206096 -8.074660313267064 -7.19106147073658 0.01 4.926487348042642e-06 8.420535026936753e-08 6.440780952179146e-07 58.5056333390114 -2.0 -5.307462628206096 -7.074660313267063 -6.19106147073658 0.1 4.926487348042642e-05 8.420535026936756e-07 6.440780952179153e-06 58.50563333901138 -1.0 -4.307462628206096 -6.074660313267063 -5.19106147073658 1.0 0.0008534898086361221 1.5807370957925124e-05 0.00011615261518329971 53.99315363116848 0.0 -3.0688016603483343 -4.801140354824869 -3.9349710075866016 10.0 0.003124585995353331 0.00016807565398856117 0.0007246839549848683 18.590354529074048 1.0 -2.5052075181101983 -3.7744951902141235 -3.139851354162161 25.0 0.0031989966444040626 0.0001703327883912275 0.0007381693697895656 18.780862302661735 1.3979400086720377 -2.494986215469992 -3.768701744011925 -3.1318439797409585 50.0 0.0031989966444040626 0.0001703327883912275 0.0007381693697895656 18.780862302661735 1.6989700043360187 -2.494986215469992 -3.768701744011925 -3.1318439797409585 75.0 0.0031989966444040626 0.0001703327883912275 0.0007381693697895656 18.780862302661735 1.8750612633917 -2.494986215469992 -3.768701744011925 -3.1318439797409585 100.0 0.0031989966444040626 0.0001703327883912275 0.0007381693697895656 18.780862302661735 2.0 -2.494986215469992 -3.768701744011925 -3.1318439797409585 250.0 0.0031989966444040626 0.0001703327883912275 0.0007381693697895656 18.780862302661735 2.3979400086720375 -2.494986215469992 -3.768701744011925 -3.1318439797409585 500.0 0.0031989966444040626 0.0001703327883912275 0.0007381693697895656 18.780862302661735 2.6989700043360187 -2.494986215469992 -3.768701744011925 -3.1318439797409585 1000.0 0.0031989966444040626 0.0001703327883912275 0.0007381693697895656 18.780862302661735 3.0 -2.494986215469992 -3.768701744011925 -3.1318439797409585 2500.0 0.0031989966444040626 0.0001703327883912275 0.0007381693697895656 18.780862302661735 3.3979400086720375 -2.494986215469992 -3.768701744011925 -3.1318439797409585 5000.0 0.0031989966444040626 0.0001703327883912275 0.0007381693697895656 18.780862302661735 3.6989700043360187 -2.494986215469992 -3.768701744011925 -3.1318439797409585 10000.0 0.0031989966444040626 0.0001703327883912275 0.0007381693697895656 18.780862302661735 4.0 -2.494986215469992 -3.768701744011925 -3.1318439797409585 ==> prazosin_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 5.284210622400106e-10 8.347284313669164e-12 6.64144626105522e-11 63.304548207935156 -6.0 -9.277019880246927 -11.078454793908032 -10.17773733707748 5e-06 2.6421053112000526e-09 4.173642156834583e-11 3.3207231305276095e-10 63.30454820793514 -5.301029995663981 -8.578049875910908 -10.379484789572013 -9.47876733274146 1e-05 5.284210622400105e-09 8.347284313669166e-11 6.64144626105522e-10 63.30454820793514 -5.0 -8.277019880246927 -10.078454793908032 -9.17773733707748 5e-05 2.642105311200052e-08 4.1736421568345814e-10 3.3207231305276095e-09 63.30454820793515 -4.301029995663981 -7.578049875910908 -9.379484789572013 -8.47876733274146 0.0001 5.284210622400104e-08 8.347284313669163e-10 6.64144626105522e-09 63.30454820793515 -4.0 -7.277019880246928 -9.078454793908032 -8.17773733707748 0.001 5.284210622400105e-07 8.347284313669166e-09 6.64144626105522e-08 63.30454820793514 -3.0 -6.277019880246927 -8.078454793908032 -7.177737337077479 0.01 5.284210622400105e-06 8.347284313669166e-08 6.641446261055221e-07 63.30454820793514 -2.0 -5.277019880246927 -7.078454793908032 -6.177737337077479 0.1 5.284210622400106e-05 8.347284313669167e-07 6.64144626105522e-06 63.30454820793514 -1.0 -4.277019880246927 -6.078454793908032 -5.177737337077479 1.0 0.0009284889796991385 1.566986173863569e-05 0.00012062045406038072 59.25316988661435 0.0 -3.032223246565295 -4.804934835465838 -3.9185790410155663 10.0 0.003160604542808088 0.0001666135543122123 0.0007256717967873496 18.96967240063508 1.0 -2.5002298400099146 -3.7782896708550893 -3.139259755432502 25.0 0.00320651558788887 0.00016885105377429518 0.0007358148788647448 18.99020181523445 1.3979400086720377 -2.4939666444984447 -3.77249622465289 -3.1332314345756673 50.0 0.00320651558788887 0.00016885105377429518 0.0007358148788647448 18.99020181523445 1.6989700043360187 -2.4939666444984447 -3.77249622465289 -3.1332314345756673 75.0 0.00320651558788887 0.00016885105377429518 0.0007358148788647448 18.99020181523445 1.8750612633917 -2.4939666444984447 -3.77249622465289 -3.1332314345756673 100.0 0.00320651558788887 0.00016885105377429518 0.0007358148788647448 18.99020181523445 2.0 -2.4939666444984447 -3.77249622465289 -3.1332314345756673 250.0 0.00320651558788887 0.00016885105377429518 0.0007358148788647448 18.99020181523445 2.3979400086720375 -2.4939666444984447 -3.77249622465289 -3.1332314345756673 500.0 0.00320651558788887 0.00016885105377429518 0.0007358148788647448 18.99020181523445 2.6989700043360187 -2.4939666444984447 -3.77249622465289 -3.1332314345756673 1000.0 0.00320651558788887 0.00016885105377429518 0.0007358148788647448 18.99020181523445 3.0 -2.4939666444984447 -3.77249622465289 -3.1332314345756673 2500.0 0.00320651558788887 0.00016885105377429518 0.0007358148788647448 18.99020181523445 3.3979400086720375 -2.4939666444984447 -3.77249622465289 -3.1332314345756673 5000.0 0.00320651558788887 0.00016885105377429518 0.0007358148788647448 18.99020181523445 3.6989700043360187 -2.4939666444984447 -3.77249622465289 -3.1332314345756673 10000.0 0.00320651558788887 0.00016885105377429518 0.0007358148788647448 18.99020181523445 4.0 -2.4939666444984447 -3.77249622465289 -3.1332314345756673 ==> prazosin_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.6721444035956879e-09 1.7314404838433415e-11 1.7015341651632062e-10 96.57533245866864 -6.0 -8.776726220331948 -10.761592432201528 -9.769159326266738 5e-06 8.360722017978438e-09 8.65720241921671e-11 8.507670825816031e-10 96.5753324586686 -5.301029995663981 -8.07775621599593 -10.06262242786551 -9.07018932193072 1e-05 1.6721444035956877e-08 1.731440483843342e-10 1.7015341651632063e-09 96.5753324586686 -5.0 -7.776726220331947 -9.761592432201528 -8.769159326266738 5e-05 8.360722017978439e-08 8.657202419216709e-10 8.50767082581603e-09 96.57533245866863 -4.301029995663981 -7.077756215995929 -9.06262242786551 -8.07018932193072 0.0001 1.6721444035956878e-07 1.7314404838433417e-09 1.701534165163206e-08 96.57533245866863 -4.0 -6.776726220331947 -8.761592432201528 -7.769159326266738 0.001 1.6721444035956874e-06 1.7314404838433417e-08 1.7015341651632063e-07 96.5753324586686 -3.0 -5.776726220331947 -7.761592432201528 -6.769159326266738 0.01 1.6721444035956876e-05 1.731440483843342e-07 1.7015341651632064e-06 96.5753324586686 -2.0 -4.776726220331947 -6.761592432201528 -5.769159326266738 0.1 0.0001672144403595688 1.7314404838433416e-06 1.701534165163208e-05 96.57533245866864 -1.0 -3.7767262203319474 -5.761592432201528 -4.769159326266738 1.0 0.0021252152269360313 3.193748221452181e-05 0.00026052643534255857 66.54297958308395 0.0 -2.67259708107841 -4.495699324372866 -3.584148202725638 10.0 0.0032186881716648507 0.0002520742562955008 0.0009007488146645226 12.768809552260098 1.0 -2.4923210959720707 -3.5984715054528627 -3.0453963007124667 25.0 0.0032571216421545058 0.0002546973792204846 0.0009108130137734494 12.788202423295859 1.3979400086720377 -2.4871660217452356 -3.5939755238072433 -3.0405707727762397 50.0 0.0032571216421545058 0.0002546973792204846 0.0009108130137734494 12.788202423295859 1.6989700043360187 -2.4871660217452356 -3.5939755238072433 -3.0405707727762397 75.0 0.0032571216421545058 0.0002546973792204846 0.0009108130137734494 12.788202423295859 1.8750612633917 -2.4871660217452356 -3.5939755238072433 -3.0405707727762397 100.0 0.0032571216421545058 0.0002546973792204846 0.0009108130137734494 12.788202423295859 2.0 -2.4871660217452356 -3.5939755238072433 -3.0405707727762397 250.0 0.0032571216421545058 0.0002546973792204846 0.0009108130137734494 12.788202423295859 2.3979400086720375 -2.4871660217452356 -3.5939755238072433 -3.0405707727762397 500.0 0.0032571216421545058 0.0002546973792204846 0.0009108130137734494 12.788202423295859 2.6989700043360187 -2.4871660217452356 -3.5939755238072433 -3.0405707727762397 1000.0 0.0032571216421545058 0.0002546973792204846 0.0009108130137734494 12.788202423295859 3.0 -2.4871660217452356 -3.5939755238072433 -3.0405707727762397 2500.0 0.0032571216421545058 0.0002546973792204846 0.0009108130137734494 12.788202423295859 3.3979400086720375 -2.4871660217452356 -3.5939755238072433 -3.0405707727762397 5000.0 0.0032571216421545058 0.0002546973792204846 0.0009108130137734494 12.788202423295859 3.6989700043360187 -2.4871660217452356 -3.5939755238072433 -3.0405707727762397 10000.0 0.0032571216421545058 0.0002546973792204846 0.0009108130137734494 12.788202423295859 4.0 -2.4871660217452356 -3.5939755238072433 -3.0405707727762397 ==> prazosin_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 6.939343872279039e-10 1.3729015538259817e-11 9.760653658841054e-11 50.54509446027341 -6.0 -9.158681590945665 -10.862360603450062 -10.010521097197863 5e-06 3.469671936139521e-09 6.864507769129907e-11 4.880326829420517e-10 50.54509446027345 -5.301029995663981 -8.459711586609647 -10.163390599114043 -9.311551092861846 1e-05 6.939343872279042e-09 1.3729015538259814e-10 9.760653658841035e-10 50.54509446027345 -5.0 -8.158681590945665 -9.862360603450062 -9.010521097197865 5e-05 3.46967193613952e-08 6.864507769129906e-10 4.880326829420516e-09 50.54509446027344 -4.301029995663981 -7.459711586609647 -9.163390599114043 -8.311551092861846 0.0001 6.93934387227904e-08 1.3729015538259812e-09 9.760653658841034e-09 50.54509446027344 -4.0 -7.158681590945665 -8.862360603450062 -8.010521097197865 0.001 6.93934387227904e-07 1.3729015538259815e-08 9.760653658841033e-08 50.54509446027343 -3.0 -6.158681590945665 -7.862360603450062 -7.010521097197864 0.01 6.93934387227904e-06 1.3729015538259815e-07 9.760653658841034e-07 50.54509446027343 -2.0 -5.158681590945665 -6.862360603450062 -6.010521097197864 0.1 6.93934387227904e-05 1.3729015538259815e-06 9.760653658841035e-06 50.54509446027343 -1.0 -4.158681590945665 -5.862360603450062 -5.010521097197864 1.0 0.0012170867300317616 2.532479798410096e-05 0.0001755633092852388 48.059089387242295 0.0 -2.9146784726884905 -4.596454010320699 -3.755566241504594 10.0 0.0033526153737312866 0.0002002614169488496 0.0008193897151099253 16.74119470845253 1.0 -2.4746162678200796 -3.6984027153109134 -3.0865094915654967 25.0 0.0033904011560412783 0.00020235440578442597 0.0008282889660629096 16.754768164786938 1.3979400086720377 -2.4697489125497913 -3.6938873354432347 -3.081818123996513 50.0 0.0033904011560412783 0.00020235440578442597 0.0008282889660629096 16.754768164786938 1.6989700043360187 -2.4697489125497913 -3.6938873354432347 -3.081818123996513 75.0 0.0033904011560412783 0.00020235440578442597 0.0008282889660629096 16.754768164786938 1.8750612633917 -2.4697489125497913 -3.6938873354432347 -3.081818123996513 100.0 0.0033904011560412783 0.00020235440578442597 0.0008282889660629096 16.754768164786938 2.0 -2.4697489125497913 -3.6938873354432347 -3.081818123996513 250.0 0.0033904011560412783 0.00020235440578442597 0.0008282889660629096 16.754768164786938 2.3979400086720375 -2.4697489125497913 -3.6938873354432347 -3.081818123996513 500.0 0.0033904011560412783 0.00020235440578442597 0.0008282889660629096 16.754768164786938 2.6989700043360187 -2.4697489125497913 -3.6938873354432347 -3.081818123996513 1000.0 0.0033904011560412783 0.00020235440578442597 0.0008282889660629096 16.754768164786938 3.0 -2.4697489125497913 -3.6938873354432347 -3.081818123996513 2500.0 0.0033904011560412783 0.00020235440578442597 0.0008282889660629096 16.754768164786938 3.3979400086720375 -2.4697489125497913 -3.6938873354432347 -3.081818123996513 5000.0 0.0033904011560412783 0.00020235440578442597 0.0008282889660629096 16.754768164786938 3.6989700043360187 -2.4697489125497913 -3.6938873354432347 -3.081818123996513 10000.0 0.0033904011560412783 0.00020235440578442597 0.0008282889660629096 16.754768164786938 4.0 -2.4697489125497913 -3.6938873354432347 -3.081818123996513 ==> prazosin_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 8.266926667461832e-10 1.3727018869274388e-11 1.0652711314738428e-10 60.22375831336511 -6.0 -9.08265591480454 -10.86242376933274 -9.97253984206864 5e-06 4.133463333730916e-09 6.863509434637195e-11 5.326355657369214e-10 60.2237583133651 -5.301029995663981 -8.383685910468522 -10.16345376499672 -9.273569837732621 1e-05 8.266926667461832e-09 1.372701886927439e-10 1.065271131473843e-09 60.2237583133651 -5.0 -8.08265591480454 -9.86242376933274 -8.97253984206864 5e-05 4.133463333730916e-08 6.863509434637196e-10 5.326355657369214e-09 60.22375831336509 -4.301029995663981 -7.383685910468522 -9.16345376499672 -8.273569837732621 0.0001 8.266926667461831e-08 1.3727018869274392e-09 1.065271131473843e-08 60.22375831336509 -4.0 -7.0826559148045405 -8.86242376933274 -7.97253984206864 0.001 8.266926667461833e-07 1.372701886927439e-08 1.0652711314738429e-07 60.22375831336512 -3.0 -6.0826559148045405 -7.8624237693327395 -6.97253984206864 0.01 8.266926667461832e-06 1.372701886927439e-07 1.0652711314738427e-06 60.22375831336511 -2.0 -5.0826559148045405 -6.8624237693327395 -5.97253984206864 0.1 8.266926667461832e-05 1.372701886927439e-06 1.065271131473843e-05 60.223758313365096 -1.0 -4.0826559148045405 -5.8624237693327395 -4.97253984206864 1.0 0.001447379427755615 2.5477410206113967e-05 0.00019202989195648773 56.81030434593696 0.0 -2.8394176044857775 -4.593844720385232 -3.7166311624355046 10.0 0.00317623947074559 0.00022280352493901992 0.0008412356091681829 14.255786445097351 1.0 -2.4980867616282074 -3.6520779425402496 -3.0750823520842285 25.0 0.0032273042271360685 0.00022535070468964507 0.0008528043631648375 14.321251986235142 1.3979400086720377 -2.491160093183392 -3.6471410795173624 -3.0691505863503767 50.0 0.0032273042271360685 0.00022535070468964507 0.0008528043631648375 14.321251986235142 1.6989700043360187 -2.491160093183392 -3.6471410795173624 -3.0691505863503767 75.0 0.0032273042271360685 0.00022535070468964507 0.0008528043631648375 14.321251986235142 1.8750612633917 -2.491160093183392 -3.6471410795173624 -3.0691505863503767 100.0 0.0032273042271360685 0.00022535070468964507 0.0008528043631648375 14.321251986235142 2.0 -2.491160093183392 -3.6471410795173624 -3.0691505863503767 250.0 0.0032273042271360685 0.00022535070468964507 0.0008528043631648375 14.321251986235142 2.3979400086720375 -2.491160093183392 -3.6471410795173624 -3.0691505863503767 500.0 0.0032273042271360685 0.00022535070468964507 0.0008528043631648375 14.321251986235142 2.6989700043360187 -2.491160093183392 -3.6471410795173624 -3.0691505863503767 1000.0 0.0032273042271360685 0.00022535070468964507 0.0008528043631648375 14.321251986235142 3.0 -2.491160093183392 -3.6471410795173624 -3.0691505863503767 2500.0 0.0032273042271360685 0.00022535070468964507 0.0008528043631648375 14.321251986235142 3.3979400086720375 -2.491160093183392 -3.6471410795173624 -3.0691505863503767 5000.0 0.0032273042271360685 0.00022535070468964507 0.0008528043631648375 14.321251986235142 3.6989700043360187 -2.491160093183392 -3.6471410795173624 -3.0691505863503767 10000.0 0.0032273042271360685 0.00022535070468964507 0.0008528043631648375 14.321251986235142 4.0 -2.491160093183392 -3.6471410795173624 -3.0691505863503767 ==> trimethoprim_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.2412586086442873e-08 1.611839930349824e-09 4.4729299003039704e-09 7.700880126321799 -6.0 -7.906137726473403 -8.79267808958894 -8.349407908031171 5e-06 6.206293043221437e-08 8.059199651749118e-09 2.236464950151985e-08 7.700880126321802 -5.301029995663981 -7.207167722137385 -8.09370808525292 -7.650437903695153 1e-05 1.2412586086442873e-07 1.6118399303498235e-08 4.4729299003039706e-08 7.700880126321802 -5.0 -6.906137726473403 -7.79267808958894 -7.349407908031171 5e-05 6.206293043221436e-07 8.05919965174912e-08 2.236464950151985e-07 7.700880126321799 -4.301029995663981 -6.207167722137385 -7.0937080852529215 -6.650437903695153 0.0001 1.2412586086442872e-06 1.611839930349824e-07 4.4729299003039707e-07 7.700880126321799 -4.0 -5.906137726473403 -6.79267808958894 -6.349407908031171 0.001 1.2412586086442872e-05 1.6118399303498233e-06 4.472929900303971e-06 7.7008801263218025 -3.0 -4.906137726473403 -5.79267808958894 -5.349407908031171 0.01 0.00012412586086442873 1.611839930349824e-05 4.4729299003039665e-05 7.7008801263218 -2.0 -3.9061377264734034 -4.79267808958894 -4.349407908031172 0.1 0.0012412586086442872 0.00016118399303498241 0.0004472929900303971 7.700880126321798 -1.0 -2.9061377264734034 -3.7926780895889403 -3.349407908031172 1.0 0.012412586086442872 0.001611839930349824 0.004472929900303969 7.700880126321799 0.0 -1.9061377264734036 -2.7926780895889403 -2.349407908031172 10.0 0.12412586086442873 0.016118399303498235 0.04472929900303969 7.700880126321802 1.0 -0.9061377264734035 -1.7926780895889403 -1.3494079080311718 25.0 0.31031465216107174 0.0402959982587456 0.11182324750759921 7.700880126321797 1.3979400086720377 -0.5081977178013661 -1.3947380809169025 -0.9514678993591343 50.0 0.6206293043221435 0.0805919965174912 0.2236464950151984 7.700880126321797 1.6989700043360187 -0.20716772213738488 -1.0937080852529213 -0.6504379036951531 75.0 0.9309439564832153 0.1208879947762368 0.33546974252279765 7.700880126321798 1.8750612633917 -0.0310764630817036 -0.91761682619724 -0.47434664463947185 100.0 1.241258608644287 0.1611839930349824 0.44729299003039685 7.700880126321797 2.0 0.09386227352659632 -0.7926780895889401 -0.3494079080311719 250.0 4.136414582470037 0.7233722368934589 1.7297882729513672 5.718237957588721 2.3979400086720375 0.6166240605152152 -0.14063816352484118 0.237992948495187 500.0 7.6896346721196185 1.13301790368661 2.9516933709856854 6.786860690461387 2.6989700043360187 0.8859057073370133 0.05423677253847843 0.4700712399377458 1000.0 9.685467851858204 1.9659108035769426 4.3635726059807 4.926707678820247 3.0 0.9861206039475301 0.2935638093287126 0.6398422066381213 2500.0 14.672374775073463 4.577058528383515 8.194895856317462 3.2056340735182434 3.3979400086720375 1.1665004116102715 0.6605864659321011 0.9135434387711862 5000.0 23.439024961882023 9.329538995505121 14.787673833246938 2.512345462425819 3.6989700043360187 1.369939541540517 0.9698601842979736 1.1698998629192452 10000.0 29.450095064144328 13.012614738563371 19.5760757324796 2.263195803136157 4.0 1.4690867010167257 1.1143645719214932 1.2917256364691094 ==> trimethoprim_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 6.195093800031772e-09 1.598283942235051e-09 3.146667910859153e-09 3.876090872419397 -6.0 -8.207952113577216 -8.79634606382583 -8.502149088701522 5e-06 3.097546900015886e-08 7.991419711175256e-09 1.573333955429576e-08 3.876090872419396 -5.301029995663981 -7.508982109241197 -8.097376059489811 -7.803179084365503 1e-05 6.195093800031771e-08 1.5982839422350513e-08 3.146667910859153e-08 3.876090872419396 -5.0 -7.207952113577216 -7.796346063825829 -7.502149088701522 5e-05 3.0975469000158866e-07 7.991419711175257e-08 1.5733339554295765e-07 3.8760908724193968 -4.301029995663981 -6.508982109241196 -7.09737605948981 -6.803179084365503 0.0001 6.195093800031773e-07 1.5982839422350515e-07 3.146667910859153e-07 3.8760908724193968 -4.0 -6.207952113577216 -6.796346063825829 -6.502149088701522 0.001 6.195093800031772e-06 1.5982839422350512e-06 3.146667910859153e-06 3.8760908724193963 -3.0 -5.207952113577216 -5.796346063825829 -5.502149088701522 0.01 6.195093800031773e-05 1.5982839422350515e-05 3.146667910859153e-05 3.8760908724193968 -2.0 -4.207952113577216 -4.796346063825829 -4.502149088701522 0.1 0.0006195093800031773 0.00015982839422350512 0.00031466679108591527 3.876090872419397 -1.0 -3.2079521135772153 -3.796346063825829 -3.5021490887015223 1.0 0.006195093800031771 0.001598283942235051 0.0031466679108591526 3.8760908724193963 0.0 -2.2079521135772153 -2.796346063825829 -2.5021490887015223 10.0 0.06195093800031772 0.01598283942235051 0.03146667910859153 3.8760908724193968 1.0 -1.2079521135772153 -1.796346063825829 -1.5021490887015223 25.0 0.1548773450007943 0.03995709855587628 0.07866669777147882 3.8760908724193968 1.3979400086720377 -0.8100121049051778 -1.3984060551537913 -1.1042090800294846 50.0 0.3097546900015886 0.07991419711175256 0.15733339554295764 3.8760908724193968 1.6989700043360187 -0.5089821092411966 -1.09737605948981 -0.8031790843655033 75.0 0.46463203500238287 0.11987129566762883 0.23600009331443644 3.8760908724193968 1.8750612633917 -0.3328908501855154 -0.921284800434129 -0.6270878253098222 100.0 0.6195093800031772 0.15982839422350512 0.3146667910859153 3.8760908724193968 2.0 -0.2079521135772154 -0.796346063825829 -0.5021490887015222 250.0 2.776956534844201 0.7172891190976293 1.4113400393423277 3.871460560195997 2.3979400086720375 0.44356908218992364 -0.14430575713570368 0.14963166252711008 500.0 4.268369218164178 1.1234915778695724 2.189857727763424 3.7992000138159456 2.6989700043360187 0.6302619792800634 0.050569821126771886 0.3404159002034177 1000.0 7.082357309495726 1.949388742722066 3.7156786205303485 3.6331169634262594 3.0 0.8501778334116229 0.2898984537837181 0.5700381435976706 2500.0 14.294993034524595 4.538667487706923 8.054825890284265 3.1496013032994563 3.3979400086720375 1.15518394807678 0.6569283665842801 0.90605615733053 5000.0 23.715238248938043 9.251869518360255 14.812504510581629 2.5632914733476686 3.6989700043360187 1.3750274920357235 0.9662294991682179 1.1706284956019708 10000.0 29.57946932777114 12.905626734749143 19.538208468438846 2.2919823992837727 4.0 1.4709903782447802 1.110779099994491 1.2908847391196356 ==> trimethoprim_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 3.643864577495725e-08 1.1013661586130087e-09 6.335005234585439e-09 33.08495134882825 -6.0 -7.438437771748217 -8.958068272101537 -8.198253021924875 5e-06 1.8219322887478628e-07 5.506830793065044e-09 3.167502617292719e-08 33.08495134882825 -5.301029995663981 -6.739467767412198 -8.259098267765518 -7.499283017588857 1e-05 3.6438645774957255e-07 1.1013661586130088e-08 6.335005234585439e-08 33.08495134882825 -5.0 -6.438437771748217 -7.958068272101536 -7.1982530219248755 5e-05 1.8219322887478626e-06 5.5068307930650434e-08 3.167502617292719e-07 33.084951348828255 -4.301029995663981 -5.739467767412198 -7.259098267765517 -6.499283017588857 0.0001 3.6438645774957253e-06 1.1013661586130087e-07 6.335005234585439e-07 33.084951348828255 -4.0 -5.438437771748217 -6.958068272101536 -6.1982530219248755 0.001 3.643864577495726e-05 1.1013661586130088e-06 6.3350052345854264e-06 33.084951348828255 -3.0 -4.438437771748217 -5.958068272101536 -5.198253021924876 0.01 0.00036438645774957253 1.1013661586130087e-05 6.335005234585425e-05 33.084951348828255 -2.0 -3.4384377717482164 -4.958068272101536 -4.198253021924876 0.1 0.0036438645774957254 0.00011013661586130088 0.0006335005234585433 33.08495134882825 -1.0 -2.4384377717482164 -3.958068272101536 -3.1982530219248764 1.0 0.03643864577495725 0.0011013661586130085 0.006335005234585429 33.084951348828255 0.0 -1.4384377717482166 -2.9580682721015363 -2.1982530219248764 10.0 0.3643864577495725 0.011013661586130085 0.06335005234585431 33.084951348828255 1.0 -0.4384377717482166 -1.9580682721015361 -1.1982530219248764 25.0 0.9109661443739313 0.02753415396532521 0.15837513086463573 33.08495134882826 1.3979400086720377 -0.040497763076178965 -1.5601282634294986 -0.8003130132528389 50.0 1.8219322887478626 0.05506830793065042 0.3167502617292715 33.08495134882826 1.6989700043360187 0.2605322325878022 -1.2590982677655174 -0.49928301758885757 75.0 2.732898433121794 0.08260246189597566 0.4751253925939074 33.08495134882825 1.8750612633917 0.43662349164348346 -1.083007008709836 -0.3231917585331762 100.0 3.6438645774957252 0.11013661586130084 0.6335005234585431 33.08495134882826 2.0 0.5615622282517834 -0.9580682721015362 -0.1982530219248763 250.0 17.984391773151877 0.49359514523751596 2.979430896879014 36.435511869748765 2.3979400086720375 1.2548957546910566 -0.3066291204637254 0.4741333171136656 500.0 24.922073514753695 0.7714396062639394 4.384731984911112 32.30592947573771 2.6989700043360187 1.396584172760535 -0.11269806790668957 0.6419430524269227 1000.0 31.2162945771393 1.3321815754708601 6.448703163438051 23.432462324894328 3.0 1.494381350353315 0.12456342292039746 0.8094723866368564 2500.0 34.70821335225712 3.055571885666167 10.2982251345006 11.358990935567576 3.3979400086720375 1.5404322584070358 0.48509250542809357 1.0127623819175646 5000.0 38.96487172859531 6.070168978765441 15.379315837464738 6.419075295086767 3.6989700043360187 1.5906732508907426 0.783200780947404 1.1869370159190733 10000.0 41.92912360468382 8.311012488936624 18.66744411880466 5.045007892900971 4.0 1.6225157849500143 0.9196539349240311 1.2710848599370228 ==> trimethoprim_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 6.260287661953558e-09 1.1768588987255246e-09 2.714309349273159e-09 5.319488741371727 -6.0 -8.203405710379226 -8.929275604427888 -8.566340657403556 5e-06 3.130143830976779e-08 5.884294493627624e-09 1.3571546746365766e-08 5.319488741371726 -5.301029995663981 -7.504435706043207 -8.230305600091869 -7.867370653067538 1e-05 6.260287661953558e-08 1.1768588987255249e-08 2.7143093492731533e-08 5.319488741371726 -5.0 -7.203405710379226 -7.929275604427888 -7.566340657403557 5e-05 3.1301438309767797e-07 5.884294493627625e-08 1.3571546746365765e-07 5.319488741371727 -4.301029995663981 -6.504435706043207 -7.230305600091869 -6.867370653067538 0.0001 6.260287661953559e-07 1.176858898725525e-07 2.7143093492731535e-07 5.319488741371727 -4.0 -6.203405710379226 -6.929275604427888 -6.566340657403557 0.001 6.260287661953559e-06 1.176858898725525e-06 2.7143093492731537e-06 5.319488741371727 -3.0 -5.203405710379226 -5.929275604427888 -5.566340657403557 0.01 6.26028766195356e-05 1.1768588987255247e-05 2.7143093492731536e-05 5.319488741371728 -2.0 -4.203405710379226 -4.929275604427888 -4.566340657403557 0.1 0.0006260287661953559 0.00011768588987255247 0.00027143093492731533 5.319488741371727 -1.0 -3.2034057103792257 -3.929275604427888 -3.566340657403557 1.0 0.0062602876619535595 0.0011768588987255248 0.0027143093492731536 5.319488741371727 0.0 -2.2034057103792257 -2.929275604427888 -2.566340657403557 10.0 0.06260287661953558 0.011768588987255248 0.027143093492731536 5.3194887413717264 1.0 -1.203405710379226 -1.9292756044278878 -1.566340657403557 25.0 0.15650719154883894 0.029421472468138123 0.06785773373182888 5.319488741371726 1.3979400086720377 -0.8054657017071883 -1.5313355957558503 -1.1684006487315193 50.0 0.3130143830976779 0.058842944936276245 0.1357154674636577 5.319488741371726 1.6989700043360187 -0.5044357060432072 -1.230305600091869 -0.8673706530675382 75.0 0.46952157464651684 0.08826441740441435 0.20357320119548655 5.319488741371727 1.8750612633917 -0.3283444469875259 -1.054214341036188 -0.6912793940118569 100.0 0.6260287661953557 0.11768588987255249 0.27143093492731546 5.319488741371726 2.0 -0.20340571037922597 -0.9292756044278878 -0.5663406574035569 250.0 2.7917095623339674 0.5285225641212731 1.214693992809146 5.282100995963137 2.3979400086720375 0.44587023413852744 -0.2769364667024938 0.08446688371801685 500.0 4.331446111394512 0.828754567029575 1.894651880072087 5.226452177415198 2.6989700043360187 0.6366329156022559 -0.0815740653078003 0.2775294251472277 1000.0 7.306369895566385 1.441739859078076 3.2455946610145534 5.067744953821601 3.0 0.8637016552201198 0.15888690534950542 0.5112942802848126 2500.0 15.384591899618865 3.3890624483036826 7.220757764215286 4.539483156269153 3.3979400086720375 1.1870859803953526 0.5300795714056347 0.8585827759004938 5000.0 26.503892711072698 7.059965703902074 13.679056018602791 3.754110688728117 3.6989700043360187 1.4233096648342338 0.8488025913291043 1.136056128081669 10000.0 33.15784827214247 10.046974447390486 18.252015075620175 3.3002819352003634 4.0 1.5205863399163733 1.0020352977137523 1.2613108188150628 ==> trimethoprim_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 9.864673063303425e-09 1.2681716451530135e-09 3.5369617848636857e-09 7.778657645442928 -6.0 -8.005917303635925 -8.896821961361365 -8.451369632498645 5e-06 4.932336531651712e-08 6.340858225765067e-09 1.7684808924318428e-08 7.778657645442928 -5.301029995663981 -7.306947299299908 -8.197851957025346 -7.752399628162626 1e-05 9.864673063303424e-08 1.2681716451530134e-08 3.536961784863686e-08 7.778657645442928 -5.0 -7.005917303635926 -7.896821961361364 -7.451369632498645 5e-05 4.932336531651711e-07 6.340858225765066e-08 1.7684808924318427e-07 7.778657645442928 -4.301029995663981 -6.306947299299908 -7.197851957025346 -6.752399628162626 0.0001 9.864673063303422e-07 1.268171645153013e-07 3.5369617848636855e-07 7.778657645442928 -4.0 -6.005917303635926 -6.896821961361365 -6.451369632498645 0.001 9.864673063303424e-06 1.2681716451530135e-06 3.536961784863686e-06 7.778657645442928 -3.0 -5.005917303635926 -5.896821961361364 -5.451369632498645 0.01 9.864673063303423e-05 1.2681716451530135e-05 3.536961784863686e-05 7.7786576454429275 -2.0 -4.005917303635926 -4.896821961361364 -4.451369632498645 0.1 0.0009864673063303424 0.00012681716451530135 0.00035369617848636856 7.7786576454429275 -1.0 -3.0059173036359264 -3.8968219613613644 -3.4513696324986456 1.0 0.009864673063303424 0.0012681716451530133 0.003536961784863688 7.778657645442929 0.0 -2.0059173036359264 -2.8968219613613644 -2.451369632498645 10.0 0.09864673063303425 0.012681716451530135 0.03536961784863688 7.778657645442928 1.0 -1.0059173036359261 -1.8968219613613644 -1.4513696324986451 25.0 0.24661682658258557 0.031704291128825335 0.08842404462159217 7.7786576454429275 1.3979400086720377 -0.6079772949638887 -1.4988819526893267 -1.0534296238266077 50.0 0.49323365316517115 0.06340858225765067 0.17684808924318435 7.7786576454429275 1.6989700043360187 -0.3069472992999075 -1.1978519570253456 -0.7523996281626265 75.0 0.7398504797477566 0.095112873386476 0.2652721338647765 7.778657645442927 1.8750612633917 -0.1308560402442263 -1.0217606979696643 -0.5763083691069453 100.0 0.9864673063303423 0.12681716451530134 0.3536961784863687 7.7786576454429275 2.0 -0.005917303635926313 -0.8968219613613644 -0.4513696324986453 250.0 4.415633765312497 0.5686535402543891 1.5846027177534974 7.765068627440793 2.3979400086720375 0.644993045631542 -0.24515225273144314 0.1999203964500495 500.0 6.744547181115759 0.8894925564713334 2.449331442327106 7.582466128633784 2.6989700043360187 0.8289527970999615 -0.0508576818655556 0.38904755761720294 1000.0 11.083960090821622 1.5388806878243853 4.1299990470194565 7.202611728458123 3.0 1.044694953381653 0.18720494950778857 0.6159499514447209 2500.0 21.095871630559795 3.5507119068446147 8.65478841936036 5.941307598032337 3.3979400086720375 1.3241974740896467 0.5503154364966807 0.9372564552931637 5000.0 31.53004763009398 7.1321893178718625 14.995941747664505 4.420809126741194 3.6989700043360187 1.4987246268047192 0.8532228626322906 1.1759737447185048 10000.0 36.87942003384914 9.854669560809455 19.063958089228997 3.7423294415180663 4.0 1.5667840827156616 0.9936420664314914 1.2802130745735767 ==> warfarin_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 4.045063943291943e-09 2.0780563151889537e-09 2.8992879596033494e-09 1.9465612715717635 -6.0 -8.393074608786108 -8.682342687267576 -8.537708648026841 5e-06 2.0225319716459718e-08 1.0390281575944768e-08 1.4496439798016744e-08 1.9465612715717637 -5.301029995663981 -7.69410460445009 -7.983372682931557 -7.8387386436908235 1e-05 4.0450639432919436e-08 2.0780563151889537e-08 2.8992879596033495e-08 1.9465612715717637 -5.0 -7.393074608786109 -7.6823426872675755 -7.537708648026842 5e-05 2.0225319716459722e-07 1.039028157594477e-07 1.4496439798016743e-07 1.946561271571764 -4.301029995663981 -6.69410460445009 -6.983372682931557 -6.8387386436908235 0.0001 4.0450639432919444e-07 2.078056315188954e-07 2.899287959603349e-07 1.946561271571764 -4.0 -6.393074608786109 -6.6823426872675755 -6.537708648026842 0.001 4.045063943291943e-06 2.0780563151889537e-06 2.899287959603349e-06 1.9465612715717635 -3.0 -5.393074608786109 -5.6823426872675755 -5.537708648026842 0.01 4.0450639432919436e-05 2.0780563151889532e-05 2.8992879596033494e-05 1.9465612715717642 -2.0 -4.393074608786109 -4.6823426872675755 -4.537708648026842 0.1 0.0004045063943291944 0.0002078056315188954 0.0002899287959603349 1.9465612715717637 -1.0 -3.3930746087861086 -3.6823426872675755 -3.5377086480268423 1.0 0.0040450639432919435 0.002078056315188954 0.00289928795960335 1.9465612715717635 0.0 -2.393074608786109 -2.6823426872675755 -2.5377086480268423 10.0 0.04045063943291943 0.020780563151889534 0.028992879596033493 1.946561271571764 1.0 -1.3930746087861088 -1.6823426872675755 -1.5377086480268423 25.0 0.1431820546359043 0.07431095410450528 0.10315035186870404 1.9267960741634933 1.3979400086720377 -0.8441114098282754 -1.1289471625989318 -0.9865292862136035 50.0 0.239800570160256 0.1268239256875783 0.17439165602127654 1.890814914143153 1.6989700043360187 -0.6201497886385103 -0.8967988078588349 -0.7584742982486725 75.0 0.33211123981222795 0.17971751604258288 0.2443076074723752 1.8479625532635138 1.8750612633917 -0.4787164261004235 -0.7454095926188218 -0.6120630093596227 100.0 0.42028569355612666 0.2329973646687409 0.31293043796753234 1.8038216619044554 2.0 -0.3764553930432826 -0.6326489910610896 -0.504552192052186 250.0 0.8948320068087756 0.561172550162361 0.7086290702672193 1.5945755125582652 2.3979400086720375 -0.04825849023048877 -0.25090358070244 -0.14958103546646442 500.0 1.0964320909176788 0.7179604119271917 0.8872400101694298 1.527148395236126 2.6989700043360187 0.039981738199555764 -0.14389950193536774 -0.0519588818679057 1000.0 1.0964320909176788 0.7179604119271917 0.8872400101694298 1.527148395236126 3.0 0.039981738199555764 -0.14389950193536774 -0.0519588818679057 2500.0 1.0964320909176788 0.7179604119271917 0.8872400101694298 1.527148395236126 3.3979400086720375 0.039981738199555764 -0.14389950193536774 -0.0519588818679057 5000.0 1.0964320909176788 0.7179604119271917 0.8872400101694298 1.527148395236126 3.6989700043360187 0.039981738199555764 -0.14389950193536774 -0.0519588818679057 10000.0 1.0964320909176788 0.7179604119271917 0.8872400101694298 1.527148395236126 4.0 0.039981738199555764 -0.14389950193536774 -0.0519588818679057 ==> warfarin_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 3.285089172619601e-09 2.1500452191223343e-09 2.6576475067211835e-09 1.5279163170161605 -6.0 -8.483452837169343 -8.667552406033794 -8.575502621601569 5e-06 1.642544586309801e-08 1.0750226095611672e-08 1.3288237533605916e-08 1.5279163170161607 -5.301029995663981 -7.784482832833324 -7.968582401697776 -7.87653261726555 1e-05 3.285089172619602e-08 2.1500452191223345e-08 2.6576475067211838e-08 1.5279163170161607 -5.0 -7.4834528371693425 -7.667552406033795 -7.575502621601569 5e-05 1.642544586309801e-07 1.0750226095611673e-07 1.3288237533605915e-07 1.5279163170161607 -4.301029995663981 -6.784482832833324 -6.968582401697776 -6.87653261726555 0.0001 3.285089172619602e-07 2.1500452191223346e-07 2.6576475067211836e-07 1.5279163170161607 -4.0 -6.4834528371693425 -6.667552406033795 -6.575502621601569 0.001 3.285089172619602e-06 2.1500452191223344e-06 2.6576475067211833e-06 1.527916317016161 -3.0 -5.4834528371693425 -5.667552406033795 -5.575502621601569 0.01 3.2850891726196016e-05 2.1500452191223347e-05 2.6576475067211834e-05 1.5279163170161607 -2.0 -4.4834528371693425 -4.667552406033795 -4.575502621601569 0.1 0.0003285089172619602 0.00021500452191223343 0.00026576475067211836 1.5279163170161612 -1.0 -3.483452837169343 -3.6675524060337947 -3.5755026216015686 1.0 0.0032850891726196015 0.002150045219122335 0.0026576475067211828 1.5279163170161603 0.0 -2.483452837169343 -2.6675524060337943 -2.5755026216015686 10.0 0.03285089172619601 0.021500452191223346 0.02657647506721183 1.5279163170161605 1.0 -1.483452837169343 -1.6675524060337945 -1.5755026216015686 25.0 0.11694373077141923 0.0769302177785755 0.0948499165844883 1.520127384898515 1.3979400086720377 -0.9320230552943956 -1.1139030381342043 -1.0229630467142998 50.0 0.1978178533613444 0.13139939098258285 0.16122389852984745 1.5054700929897413 1.6989700043360187 -0.7037345152342036 -0.8814066476644922 -0.7925705814493478 75.0 0.2779951543264267 0.18635759112123068 0.2276104288112643 1.4917297044561135 1.8750612633917 -0.5559627741093878 -0.7296529119258904 -0.6428078430176392 100.0 0.3575411748547819 0.24181361990740846 0.29403796652402303 1.4785816241106933 2.0 -0.44667393712855424 -0.6165192415891891 -0.5315965893588717 250.0 0.8133172207224675 0.5855250996208843 0.6900852459565434 1.389039037351386 2.3979400086720375 -0.08974003209482949 -0.232454483353007 -0.16109725772391847 500.0 1.0177514525212779 0.7509458420582368 0.8742289296972415 1.3552927461876139 2.6989700043360187 0.007641730871162657 -0.12439138302696796 -0.05837482607790268 1000.0 1.0177514525212779 0.7509458420582368 0.8742289296972415 1.3552927461876139 3.0 0.007641730871162657 -0.12439138302696796 -0.05837482607790268 2500.0 1.0177514525212779 0.7509458420582368 0.8742289296972415 1.3552927461876139 3.3979400086720375 0.007641730871162657 -0.12439138302696796 -0.05837482607790268 5000.0 1.0177514525212779 0.7509458420582368 0.8742289296972415 1.3552927461876139 3.6989700043360187 0.007641730871162657 -0.12439138302696796 -0.05837482607790268 10000.0 1.0177514525212779 0.7509458420582368 0.8742289296972415 1.3552927461876139 4.0 0.007641730871162657 -0.12439138302696796 -0.05837482607790268 ==> warfarin_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 3.787482719171971e-09 1.6508086959690711e-09 2.5004818352952853e-09 2.2943195831353504 -6.0 -8.42164934000393 -8.782303252054474 -8.601976296029202 5e-06 1.8937413595859857e-08 8.254043479845357e-09 1.2502409176476426e-08 2.2943195831353504 -5.301029995663981 -7.722679335667911 -8.083333247718455 -7.903006291693183 1e-05 3.7874827191719715e-08 1.6508086959690714e-08 2.5004818352952855e-08 2.2943195831353504 -5.0 -7.421649340003929 -7.782303252054474 -7.601976296029202 5e-05 1.8937413595859857e-07 8.254043479845358e-08 1.2502409176476427e-07 2.29431958313535 -4.301029995663981 -6.722679335667911 -7.083333247718455 -6.903006291693183 0.0001 3.7874827191719713e-07 1.6508086959690716e-07 2.5004818352952854e-07 2.29431958313535 -4.0 -6.421649340003929 -6.782303252054474 -6.601976296029202 0.001 3.7874827191719704e-06 1.6508086959690714e-06 2.5004818352952857e-06 2.29431958313535 -3.0 -5.421649340003929 -5.782303252054474 -5.601976296029202 0.01 3.787482719171972e-05 1.6508086959690718e-05 2.5004818352952853e-05 2.2943195831353504 -2.0 -4.421649340003929 -4.782303252054474 -4.601976296029202 0.1 0.00037874827191719713 0.0001650808695969072 0.00025004818352952854 2.2943195831353496 -1.0 -3.4216493400039294 -3.782303252054474 -3.6019762960292017 1.0 0.003787482719171971 0.0016508086959690718 0.002500481835295285 2.2943195831353496 0.0 -2.4216493400039294 -2.782303252054474 -2.6019762960292017 10.0 0.03787482719171971 0.016508086959690717 0.025004818352952846 2.2943195831353496 1.0 -1.4216493400039294 -1.7823032520544742 -1.6019762960292019 25.0 0.1346231852312433 0.059246936107595495 0.08930851725337549 2.272238770065015 1.3979400086720377 -0.8708801380996755 -1.2273341038152412 -1.0491071209574583 50.0 0.22652587340476835 0.10161877462144063 0.15172106536484684 2.2291734401309484 1.6989700043360187 -0.6448821864318234 -0.9930260463707654 -0.8189541164012946 75.0 0.31709455273985043 0.1447535334466993 0.2142441526525149 2.190582469315749 1.8750612633917 -0.49881121850695176 -0.8393708263039865 -0.6690910224054691 100.0 0.40663870388203016 0.18867546522153866 0.27698871210218223 2.155228309120975 2.0 -0.39079128757099146 -0.7242845704851106 -0.5575379290280509 250.0 0.8981290612146866 0.4701941343152789 0.6498423012094807 1.910123916204503 2.3979400086720375 -0.046661250698021496 -0.32772279301285856 -0.18719202185544015 500.0 1.1118551676746835 0.6116323201203749 0.8246493532664018 1.8178489446990964 2.6989700043360187 0.04604821892208538 -0.21350957349015096 -0.08373067728403294 1000.0 1.1118551676746835 0.6116323201203749 0.8246493532664018 1.8178489446990964 3.0 0.04604821892208538 -0.21350957349015096 -0.08373067728403294 2500.0 1.1118551676746835 0.6116323201203749 0.8246493532664018 1.8178489446990964 3.3979400086720375 0.04604821892208538 -0.21350957349015096 -0.08373067728403294 5000.0 1.1118551676746835 0.6116323201203749 0.8246493532664018 1.8178489446990964 3.6989700043360187 0.04604821892208538 -0.21350957349015096 -0.08373067728403294 10000.0 1.1118551676746835 0.6116323201203749 0.8246493532664018 1.8178489446990964 4.0 0.04604821892208538 -0.21350957349015096 -0.08373067728403294 ==> warfarin_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 3.1986435535331088e-09 2.052831524435008e-09 2.5624746480938255e-09 1.5581617465726798 -6.0 -8.49503415358851 -8.687646691647709 -8.59134042261811 5e-06 1.5993217767665546e-08 1.0264157622175042e-08 1.2812373240469126e-08 1.5581617465726796 -5.301029995663981 -7.796064149252491 -7.988676687311691 -7.892370418282091 1e-05 3.198643553533109e-08 2.0528315244350084e-08 2.5624746480938255e-08 1.5581617465726796 -5.0 -7.495034153588509 -7.68764669164771 -7.59134042261811 5e-05 1.5993217767665549e-07 1.0264157622175042e-07 1.2812373240469124e-07 1.55816174657268 -4.301029995663981 -6.796064149252491 -6.988676687311691 -6.892370418282091 0.0001 3.1986435535331097e-07 2.0528315244350083e-07 2.5624746480938254e-07 1.55816174657268 -4.0 -6.495034153588509 -6.68764669164771 -6.59134042261811 0.001 3.1986435535331086e-06 2.052831524435008e-06 2.5624746480938254e-06 1.5581617465726798 -3.0 -5.49503415358851 -5.68764669164771 -5.59134042261811 0.01 3.198643553533109e-05 2.052831524435008e-05 2.5624746480938255e-05 1.5581617465726796 -2.0 -4.49503415358851 -4.68764669164771 -4.59134042261811 0.1 0.00031986435535331096 0.0002052831524435008 0.0002562474648093828 1.55816174657268 -1.0 -3.49503415358851 -3.6876466916477098 -3.5913404226181096 1.0 0.003198643553533109 0.0020528315244350078 0.0025624746480938272 1.55816174657268 0.0 -2.49503415358851 -2.6876466916477098 -2.5913404226181096 10.0 0.03198643553533109 0.02052831524435008 0.02562474648093827 1.55816174657268 1.0 -1.4950341535885099 -1.6876466916477095 -1.5913404226181098 25.0 0.1139149962821453 0.07351003339183736 0.09150898961594722 1.5496523539165548 1.3979400086720377 -0.9434190996796472 -1.1336533799726483 -1.0385362398261475 50.0 0.19297682022020157 0.12569087253482347 0.1557415323941334 1.5353288295992702 1.6989700043360187 -0.7144948539716743 -0.9006962589225254 -0.8075955564470998 75.0 0.27136748803501753 0.1784546181138152 0.22006085850462906 1.5206526505351863 1.8750612633917 -0.5664421854632518 -0.7484722087316023 -0.657457197097427 100.0 0.3490220001373532 0.23180920360096546 0.28444070013107464 1.5056434115452848 2.0 -0.45714719700323136 -0.6348693250861273 -0.5460082610446793 250.0 0.7970434873072636 0.5647891647602274 0.6709407764280303 1.411223049304843 2.3979400086720375 -0.09851798251562847 -0.24811364363114877 -0.1733158130733887 500.0 0.9990091492569073 0.726253133552603 0.851782557402738 1.3755660431646846 2.6989700043360187 -0.0004305343429935468 -0.13891198075422098 -0.06967125754860737 1000.0 0.9990091492569073 0.726253133552603 0.851782557402738 1.3755660431646846 3.0 -0.0004305343429935468 -0.13891198075422098 -0.06967125754860737 2500.0 0.9990091492569073 0.726253133552603 0.851782557402738 1.3755660431646846 3.3979400086720375 -0.0004305343429935468 -0.13891198075422098 -0.06967125754860737 5000.0 0.9990091492569073 0.726253133552603 0.851782557402738 1.3755660431646846 3.6989700043360187 -0.0004305343429935468 -0.13891198075422098 -0.06967125754860737 10000.0 0.9990091492569073 0.726253133552603 0.851782557402738 1.3755660431646846 4.0 -0.0004305343429935468 -0.13891198075422098 -0.06967125754860737 ==> warfarin_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 3.421857854615637e-09 1.9315291686755363e-09 2.5708788880948086e-09 1.771579694528781 -6.0 -8.465738035191833 -8.71409872904172 -8.589918382116776 5e-06 1.710928927307819e-08 9.657645843377685e-09 1.2854394440474042e-08 1.7715796945287807 -5.301029995663981 -7.766768030855816 -8.0151287247057 -7.890948377780758 1e-05 3.421857854615638e-08 1.931529168675537e-08 2.570878888094809e-08 1.7715796945287807 -5.0 -7.465738035191834 -7.7140987290417184 -7.589918382116776 5e-05 1.7109289273078187e-07 9.657645843377682e-08 1.2854394440474042e-07 1.7715796945287812 -4.301029995663981 -6.766768030855816 -7.0151287247057 -6.890948377780758 0.0001 3.4218578546156374e-07 1.9315291686755364e-07 2.570878888094809e-07 1.7715796945287812 -4.0 -6.465738035191834 -6.714098729041719 -6.589918382116776 0.001 3.4218578546156375e-06 1.9315291686755363e-06 2.5708788880948087e-06 1.7715796945287814 -3.0 -5.465738035191834 -5.714098729041719 -5.589918382116776 0.01 3.421857854615637e-05 1.9315291686755367e-05 2.570878888094809e-05 1.7715796945287807 -2.0 -4.465738035191834 -4.7140987290417184 -4.589918382116776 0.1 0.00034218578546156374 0.0001931529168675537 0.0002570878888094809 1.7715796945287805 -1.0 -3.4657380351918343 -3.714098729041719 -3.5899183821167764 1.0 0.0034218578546156377 0.0019315291686755364 0.0025708788880948086 1.7715796945287814 0.0 -2.465738035191834 -2.714098729041719 -2.5899183821167764 10.0 0.03421857854615637 0.019315291686755363 0.025708788880948075 1.771579694528781 1.0 -1.4657380351918343 -1.714098729041719 -1.5899183821167766 25.0 0.12175648068765431 0.06920459780357091 0.09179383571878544 1.7593698186534616 1.3979400086720377 -0.9145079134646055 -1.1598650510000819 -1.0371864822323436 50.0 0.20576948354828462 0.11842105384311256 0.15610073379244851 1.7376089544085094 1.6989700043360187 -0.6866190324369725 -0.9265710783983176 -0.8065950554176451 75.0 0.2888630998202095 0.16827304762849768 0.2204719350714771 1.716633197598838 1.8750612633917 -0.5393079326036901 -0.7739854396010423 -0.6566466861023661 100.0 0.37107751955097223 0.21877467234155498 0.2849251879934116 1.6961630685093168 2.0 -0.43053535508449736 -0.6600029579281679 -0.5452691565063326 250.0 0.8370750223510922 0.5362506942679671 0.6699866132171203 1.560977041705799 2.3979400086720375 -0.07723561687771585 -0.2706321325385911 -0.17393387470815355 500.0 1.0444586443868074 0.6917755074950321 0.8500181814398194 1.5098231045630188 2.6989700043360187 0.01889124865316201 -0.16003481836683742 -0.07057178485683745 1000.0 1.0444586443868074 0.6917755074950321 0.8500181814398194 1.5098231045630188 3.0 0.01889124865316201 -0.16003481836683742 -0.07057178485683745 2500.0 1.0444586443868074 0.6917755074950321 0.8500181814398194 1.5098231045630188 3.3979400086720375 0.01889124865316201 -0.16003481836683742 -0.07057178485683745 5000.0 1.0444586443868074 0.6917755074950321 0.8500181814398194 1.5098231045630188 3.6989700043360187 0.01889124865316201 -0.16003481836683742 -0.07057178485683745 10000.0 1.0444586443868074 0.6917755074950321 0.8500181814398194 1.5098231045630188 4.0 0.01889124865316201 -0.16003481836683742 -0.07057178485683745