File Name : suplementary figures s1_ s2_ s3_ s4.pdf Caption : figure s1: lung in vivo micro computed tomography. panel a represents the transversal section of experimental mice with nodular metastatic lesions (*) and the normal black alveolar space (#). in panel b the voxel density displacement to the right comparing week 1 and week 4 is presented. in panel c the macroscopic aspect of the metastatic lungs is presented (black arrow indicates the metastatic lung nodules). figure s2: comparison of the primary and metastatic percentage growth in panel a. in panel b the ratio between these two data is presented. the dotted lines (red, blue, and black) are guide to the eye and represent the normal gaussian distribution of the data. figure s3: ratio between left and right dir fluorescence. the dotted lines (red and blue) are guide to the eye and represent the linear correlation between the data. figure s4: typical dir fluorescence signals detected in an experimental mouse. yellow circle highlights the nedir fluorescent signal in the primary tumor.