# Electronic Supplementary Material (ESI) for Chemical Communications
# This journal is © The Royal Society of Chemistry 2014

#######################################################################
#
#                 Cambridge Crystallographic Data Centre
#                                CCDC 
# 
#######################################################################
# 
#  This CIF contains data from an original supplementary publication
#  deposited with the CCDC, and may include chemical, crystal,
#  experimental, refinement, atomic coordinates,
#  anisotropic displacement parameters and molecular geometry data,
#  as required by the journal to which it was submitted.
#
#  This CIF is provided on the understanding that it is used for bona
#  fide research purposes only. It may contain copyright material
#  of the CCDC or of third parties, and may not be copied or further
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#  except for the purpose of generating routine backup copies
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#  data retrieval see:
#                         www.ccdc.cam.ac.uk
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#  from this site to visualise CIF-encoded structures and 
#  to carry out CIF format checking respectively.
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data_ef08
_audit_creation_date             2013-09-27
_audit_creation_method           
;
  Olex2 1.2
  (compiled 2013.04.25 svn.r2679, GUI svn.r4466)
;
_chemical_name_common            ?
_chemical_name_systematic        
;
 ? 
;
_chemical_formula_moiety         'C17 H20 O'
_chemical_formula_sum            'C17 H20 O'
_chemical_formula_weight         240.33
_chemical_absolute_configuration unk
_chemical_melting_point          ?
loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'

_space_group_crystal_system      monoclinic
_space_group_IT_number           9
_space_group_name_H-M_alt        'C 1 c 1'
_space_group_name_Hall           'C -2yc'
loop_
_space_group_symop_id
_space_group_symop_operation_xyz
1 'x, y, z'
2 'x, -y, z+1/2'
3 'x+1/2, y+1/2, z'
4 'x+1/2, -y+1/2, z+1/2'

_cell_length_a                   16.9694(6)
_cell_length_b                   10.1758(6)
_cell_length_c                   7.7382(3)
_cell_angle_alpha                90.00
_cell_angle_beta                 92.801(3)
_cell_angle_gamma                90.00
_cell_volume                     1334.61(11)
_cell_formula_units_Z            4
_cell_measurement_reflns_used    9783
_cell_measurement_temperature    100(2)
_cell_measurement_theta_max      39.30
_cell_measurement_theta_min      2.33
_exptl_absorpt_coefficient_mu    0.072
_exptl_absorpt_correction_T_max  0.9742
_exptl_absorpt_correction_T_min  0.9602
_exptl_absorpt_correction_type   multi-scan
_exptl_absorpt_process_details   'SCALE (Bruker, 2009)'
_exptl_crystal_colour            colourless
_exptl_crystal_density_diffrn    1.196
_exptl_crystal_density_meas      'not measured'
_exptl_crystal_density_method    'not measured'
_exptl_crystal_description       block
_exptl_crystal_F_000             520
_exptl_crystal_size_max          0.57
_exptl_crystal_size_mid          0.47
_exptl_crystal_size_min          0.37
_exptl_special_details           
;
 ? 
;
_diffrn_reflns_av_R_equivalents  0.0359
_diffrn_reflns_av_unetI/netI     0.0294
_diffrn_reflns_limit_h_max       30
_diffrn_reflns_limit_h_min       -30
_diffrn_reflns_limit_k_max       17
_diffrn_reflns_limit_k_min       -18
_diffrn_reflns_limit_l_max       13
_diffrn_reflns_limit_l_min       -13
_diffrn_reflns_number            28192
_diffrn_reflns_theta_full        39.38
_diffrn_reflns_theta_max         39.38
_diffrn_reflns_theta_min         2.33
_diffrn_ambient_temperature      100(2)
_diffrn_detector_area_resol_mean ?
_diffrn_measured_fraction_theta_full 0.993
_diffrn_measured_fraction_theta_max 0.993
_diffrn_measurement_device_type  'Bruker APEX-II CCD'
_diffrn_measurement_method       '\f and \w scans'
_diffrn_radiation_monochromator  graphite
_diffrn_radiation_type           MoK\a
_diffrn_radiation_wavelength     0.71073
_diffrn_source                   'fine-focus sealed tube'
_reflns_number_gt                7385
_reflns_number_total             7745
_reflns_threshold_expression     >2sigma(I)
_computing_cell_refinement       'Bruker APEX2 (Bruker, 2009)'
_computing_data_collection       'Bruker APEX2 (Bruker, 2009)'
_computing_data_reduction        'Bruker APEX2 (Bruker, 2009)'
_computing_molecular_graphics    
;
O. V. Dolomanov, L. J. Bourhis, R. J. Gildea, J. A. K. Howard and H. Puschmann,
OLEX2: a complete structure solution, refinement and analysis program.
J. Appl. Cryst. (2009). 42, 339-341.
;
_computing_publication_material  
;
O. V. Dolomanov, L. J. Bourhis, R. J. Gildea, J. A. K. Howard and H. Puschmann,
OLEX2: a complete structure solution, refinement and analysis program.
J. Appl. Cryst. (2009). 42, 339-341.
;
_computing_structure_refinement  
;
SHELXL, G.M. Sheldrick, Acta Cryst.
(2008). A64, 112-122
;
_computing_structure_solution    
;
SHELXS, G.M. Sheldrick, Acta Cryst.
(2008). A64, 112-122
;
_refine_diff_density_max         0.441
_refine_diff_density_min         -0.207
_refine_diff_density_rms         0.047
_refine_ls_abs_structure_details 'Flack H D (1983), Acta Cryst. A39, 876-881'
_refine_ls_abs_structure_Flack   0.3(5)
_refine_ls_extinction_coef       ?
_refine_ls_extinction_method     none
_refine_ls_goodness_of_fit_ref   1.064
_refine_ls_hydrogen_treatment    constr
_refine_ls_matrix_type           full
_refine_ls_number_parameters     164
_refine_ls_number_reflns         7745
_refine_ls_number_restraints     2
_refine_ls_R_factor_all          0.0344
_refine_ls_R_factor_gt           0.0323
_refine_ls_restrained_S_all      1.064
_refine_ls_shift/su_max          0.001
_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details     
'calc w=1/[\s^2^(Fo^2^)+(0.0551P)^2^+0.0964P] where P=(Fo^2^+2Fc^2^)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.0884
_refine_ls_wR_factor_ref         0.0898
_refine_special_details          
;
 Refinement of F^2^ against ALL reflections.  The weighted R-factor wR and 
 goodness of fit S are based on F^2^, conventional R-factors R are based 
 on F, with F set to zero for negative F^2^. The threshold expression of 
 F^2^ > 2sigma(F^2^) is used only for calculating R-factors(gt) etc. and is 
 not relevant to the choice of reflections for refinement.  R-factors based 
 on F^2^ are statistically about twice as large as those based on F, and R- 
 factors based on ALL data will be even larger. 
;
_olex2_refinement_description    
;
1. Others
 Fixed Uiso: H2A(0.023) H2B(0.023) H3A(0.027) H3B(0.027) H4A(0.029) H4B(0.029)
 H5A(0.02) H5B(0.02) H8(0.017) H9A(0.02) H9B(0.02) H10(0.018) H11A(0.031)
 H11B(0.031) H11C(0.031) H13(0.019) H14(0.023) H15(0.026) H16(0.027) H17(0.022)
 Fixed X: H2A(0.1657) H2B(0.1362) H3A(0.1401) H3B(0.1824) H4A(0.2648)
 H4B(0.265) H5A(0.3417) H5B(0.3817) H8(0.4329) H9A(0.2998) H9B(0.3207)
 H10(0.3255) H11A(0.4946) H11B(0.4482) H11C(0.4317) H13(0.4757) H14(0.5968)
 H15(0.6685) H16(0.6192) H17(0.4987)
 Fixed Y: H2A(0.3092) H2B(0.2481) H3A(0.0929) H3B(0.0424) H4A(0.1596)
 H4B(0.0053) H5A(0.0309) H5B(0.1256) H8(0.4565) H9A(0.5456) H9B(0.5253)
 H10(0.2567) H11A(0.2888) H11B(0.1617) H11C(0.302) H13(0.0499) H14(-0.0199)
 H15(0.1162) H16(0.3244) H17(0.3957)
 Fixed Z: H2A(0.5045) H2B(0.6808) H3A(0.4388) H3B(0.6164) H4A(0.339)
 H4B(0.3797) H5A(0.6288) H5B(0.4934) H8(0.8964) H9A(0.9097) H9B(0.712)
 H10(1.0223) H11A(1.0872) H11B(1.1493) H11C(1.2338) H13(0.8581) H14(0.7613)
 H15(0.5815) H16(0.5054) H17(0.606)
;
_atom_sites_solution_hydrogens   geom
_atom_sites_solution_primary     direct
_atom_sites_solution_secondary   difmap
loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_symmetry_multiplicity
_atom_site_calc_flag
_atom_site_refinement_flags
_atom_site_disorder_assembly
_atom_site_disorder_group
O1 O 0.24338(3) 0.39525(5) 0.79486(6) 0.01752(8) Uani 1 1 d . . .
C1 C 0.25476(3) 0.28727(5) 0.69043(7) 0.01409(8) Uani 1 1 d . . .
C2 C 0.17917(3) 0.24605(6) 0.59867(8) 0.01935(9) Uani 1 1 d . . .
H2A H 0.1657 0.3092 0.5045 0.023 Uiso 1 1 calc R . .
H2B H 0.1362 0.2481 0.6808 0.023 Uiso 1 1 calc R . .
C3 C 0.18502(4) 0.10844(7) 0.52294(9) 0.02248(11) Uani 1 1 d . . .
H3A H 0.1401 0.0929 0.4388 0.027 Uiso 1 1 calc R . .
H3B H 0.1824 0.0424 0.6164 0.027 Uiso 1 1 calc R . .
C4 C 0.26268(4) 0.09366(7) 0.43272(9) 0.02385(11) Uani 1 1 d . . .
H4A H 0.2648 0.1596 0.3390 0.029 Uiso 1 1 calc R . .
H4B H 0.2650 0.0053 0.3797 0.029 Uiso 1 1 calc R . .
C5 C 0.33388(3) 0.11211(6) 0.55970(7) 0.01695(9) Uani 1 1 d . . .
H5A H 0.3417 0.0309 0.6288 0.020 Uiso 1 1 calc R . .
H5B H 0.3817 0.1256 0.4934 0.020 Uiso 1 1 calc R . .
C6 C 0.32490(3) 0.22685(5) 0.68091(6) 0.01215(7) Uani 1 1 d . . .
C7 C 0.39420(3) 0.27000(5) 0.79542(6) 0.01192(7) Uani 1 1 d . . .
C8 C 0.38371(3) 0.40303(5) 0.87891(7) 0.01449(8) Uani 1 1 d . . .
H8 H 0.4329 0.4565 0.8964 0.017 Uiso 1 1 calc R . .
C9 C 0.31092(4) 0.47874(5) 0.82124(7) 0.01649(9) Uani 1 1 d . . .
H9A H 0.2998 0.5456 0.9097 0.020 Uiso 1 1 calc R . .
H9B H 0.3207 0.5253 0.7120 0.020 Uiso 1 1 calc R . .
C10 C 0.37977(3) 0.28176(5) 0.98949(7) 0.01476(8) Uani 1 1 d . . .
H10 H 0.3255 0.2567 1.0223 0.018 Uiso 1 1 calc R . .
C11 C 0.44423(4) 0.25630(7) 1.12705(8) 0.02096(10) Uani 1 1 d . . .
H11A H 0.4946 0.2888 1.0872 0.031 Uiso 1 1 calc R . .
H11B H 0.4482 0.1617 1.1493 0.031 Uiso 1 1 calc R . .
H11C H 0.4317 0.3020 1.2338 0.031 Uiso 1 1 calc R . .
C12 C 0.47409(3) 0.22939(5) 0.74064(6) 0.01297(8) Uani 1 1 d . . .
C13 C 0.50466(3) 0.10600(5) 0.78633(7) 0.01581(8) Uani 1 1 d . . .
H13 H 0.4757 0.0499 0.8581 0.019 Uiso 1 1 calc R . .
C14 C 0.57675(3) 0.06411(6) 0.72849(8) 0.01955(10) Uani 1 1 d . . .
H14 H 0.5968 -0.0199 0.7613 0.023 Uiso 1 1 calc R . .
C15 C 0.61958(3) 0.14508(7) 0.62250(8) 0.02197(11) Uani 1 1 d . . .
H15 H 0.6685 0.1162 0.5815 0.026 Uiso 1 1 calc R . .
C16 C 0.59014(4) 0.26851(7) 0.57715(9) 0.02263(11) Uani 1 1 d . . .
H16 H 0.6192 0.3244 0.5054 0.027 Uiso 1 1 calc R . .
C17 C 0.51801(3) 0.31077(6) 0.63663(7) 0.01819(9) Uani 1 1 d . . .
H17 H 0.4987 0.3957 0.6060 0.022 Uiso 1 1 calc R . .

loop_
_atom_site_aniso_label
_atom_site_aniso_U_11
_atom_site_aniso_U_22
_atom_site_aniso_U_33
_atom_site_aniso_U_23
_atom_site_aniso_U_13
_atom_site_aniso_U_12
O1 0.01484(16) 0.01822(18) 0.01961(17) -0.00234(13) 0.00196(13) 0.00573(13)
C1 0.01234(17) 0.01617(19) 0.01370(18) 0.00070(15) 0.00004(14) 0.00279(15)
C2 0.01257(18) 0.0247(2) 0.0203(2) 0.00157(19) -0.00327(16) 0.00221(18)
C3 0.0178(2) 0.0252(3) 0.0237(2) -0.0011(2) -0.00712(19) -0.0019(2)
C4 0.0231(2) 0.0293(3) 0.0186(2) -0.0077(2) -0.00511(19) 0.0013(2)
C5 0.01623(19) 0.0181(2) 0.0163(2) -0.00530(16) -0.00091(16) 0.00176(16)
C6 0.01137(16) 0.01334(17) 0.01173(17) -0.00035(14) 0.00027(13) 0.00177(13)
C7 0.01148(16) 0.01208(17) 0.01216(16) -0.00098(13) 0.00032(13) 0.00206(13)
C8 0.01638(19) 0.01238(18) 0.01458(18) -0.00200(14) -0.00054(15) 0.00279(15)
C9 0.0201(2) 0.01396(18) 0.0154(2) -0.00088(15) 0.00022(16) 0.00540(16)
C10 0.01580(18) 0.01697(19) 0.01142(17) -0.00003(15) -0.00025(14) 0.00390(15)
C11 0.0232(2) 0.0236(2) 0.0154(2) -0.00089(18) -0.00502(18) 0.0063(2)
C12 0.01134(16) 0.01365(18) 0.01390(18) -0.00138(14) 0.00053(13) 0.00099(14)
C13 0.01353(18) 0.01478(19) 0.0191(2) -0.00092(16) 0.00110(15) 0.00291(15)
C14 0.01502(19) 0.0211(2) 0.0225(2) -0.00500(19) 0.00028(17) 0.00570(17)
C15 0.01324(19) 0.0311(3) 0.0219(2) -0.0078(2) 0.00317(17) 0.00179(19)
C16 0.0190(2) 0.0282(3) 0.0213(3) -0.0020(2) 0.00713(19) -0.0032(2)
C17 0.0181(2) 0.0183(2) 0.0185(2) 0.00132(17) 0.00385(17) 0.00002(17)

_geom_special_details            
;
 All esds (except the esd in the dihedral angle between two l.s. planes) 
 are estimated using the full covariance matrix.  The cell esds are taken 
 into account individually in the estimation of esds in distances, angles 
 and torsion angles; correlations between esds in cell parameters are only 
 used when they are defined by crystal symmetry.  An approximate (isotropic) 
 treatment of cell esds is used for estimating esds involving l.s. planes. 
;
loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
_geom_bond_site_symmetry_2
_geom_bond_publ_flag
O1 C1 1.3830(7) . ?
O1 C9 1.4332(8) . ?
C1 C2 1.4955(8) . ?
C1 C6 1.3449(7) . ?
C2 C3 1.5230(10) . ?
C3 C4 1.5285(10) . ?
C4 C5 1.5313(8) . ?
C5 C6 1.5100(7) . ?
C6 C7 1.5030(7) . ?
C7 C8 1.5142(7) . ?
C7 C10 1.5380(7) . ?
C7 C12 1.4982(7) . ?
C8 C9 1.5048(8) . ?
C8 C10 1.5051(8) . ?
C10 C11 1.5109(8) . ?
C12 C13 1.3974(7) . ?
C12 C17 1.3956(8) . ?
C13 C14 1.3899(7) . ?
C14 C15 1.3922(10) . ?
C15 C16 1.3903(10) . ?
C16 C17 1.3965(8) . ?

loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
_geom_angle_site_symmetry_1
_geom_angle_site_symmetry_3
_geom_angle_publ_flag
C1 O1 C9 114.88(4) . . ?
O1 C1 C2 111.06(4) . . ?
C6 C1 O1 122.98(5) . . ?
C6 C1 C2 125.92(5) . . ?
C1 C2 C3 111.72(5) . . ?
C2 C3 C4 109.88(5) . . ?
C3 C4 C5 111.45(5) . . ?
C6 C5 C4 113.14(5) . . ?
C1 C6 C5 120.26(5) . . ?
C1 C6 C7 120.21(4) . . ?
C7 C6 C5 119.49(4) . . ?
C6 C7 C8 114.07(4) . . ?
C6 C7 C10 116.18(4) . . ?
C8 C7 C10 59.08(3) . . ?
C12 C7 C6 116.44(4) . . ?
C12 C7 C8 119.61(4) . . ?
C12 C7 C10 119.15(4) . . ?
C9 C8 C7 116.30(4) . . ?
C9 C8 C10 121.98(5) . . ?
C10 C8 C7 61.25(3) . . ?
O1 C9 C8 112.20(4) . . ?
C8 C10 C7 59.67(3) . . ?
C8 C10 C11 119.36(5) . . ?
C11 C10 C7 122.02(5) . . ?
C13 C12 C7 120.41(5) . . ?
C17 C12 C7 121.04(5) . . ?
C17 C12 C13 118.49(5) . . ?
C14 C13 C12 121.05(5) . . ?
C13 C14 C15 120.08(6) . . ?
C16 C15 C14 119.46(5) . . ?
C15 C16 C17 120.32(6) . . ?
C12 C17 C16 120.58(6) . . ?

_database_code_depnum_ccdc_archive 'CCDC 963880'