# Electronic Supplementary Material (ESI) for Chemical Communications
# This journal is © The Royal Society of Chemistry 2014

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#                                CCDC 
# 
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# 
#  This CIF contains data from an original supplementary publication
#  deposited with the CCDC, and may include chemical, crystal,
#  experimental, refinement, atomic coordinates,
#  anisotropic displacement parameters and molecular geometry data,
#  as required by the journal to which it was submitted.
#
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#  fide research purposes only. It may contain copyright material
#  of the CCDC or of third parties, and may not be copied or further
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#  except for the purpose of generating routine backup copies
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#  data retrieval see:
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data_i1009

_audit_creation_method           SHELXL-97
_chemical_name_systematic        
; 
 ? 
;
_chemical_name_common            ?
_chemical_melting_point          ?
_chemical_formula_moiety         ?
_chemical_formula_sum            'C16 H30 Cl4 N2 O'
_chemical_formula_weight         408.22

loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
Cl Cl 0.1484 0.1585 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
N N 0.0061 0.0033 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'

_symmetry_cell_setting           triclinic
_symmetry_space_group_name_H-M   'P -1'
_symmetry_Int_Tables_number      2

loop_
_symmetry_equiv_pos_as_xyz
'x, y, z'
'-x, -y, -z'

_cell_length_a                   7.0484(6)
_cell_length_b                   10.8646(9)
_cell_length_c                   14.7271(14)
_cell_angle_alpha                90.854(7)
_cell_angle_beta                 99.683(7)
_cell_angle_gamma                105.453(7)
_cell_volume                     1069.40(16)
_cell_formula_units_Z            2
_cell_measurement_temperature    120(2)
_cell_measurement_reflns_used    11192
_cell_measurement_theta_min      2.33
_cell_measurement_theta_max      25.69

_exptl_crystal_description       plate
_exptl_crystal_colour            colorless
_exptl_crystal_size_max          0.60
_exptl_crystal_size_mid          0.19
_exptl_crystal_size_min          0.02
_exptl_crystal_density_meas      ?
_exptl_crystal_density_diffrn    1.268
_exptl_crystal_density_method    'not measured'
_exptl_crystal_F_000             432
_exptl_absorpt_coefficient_mu    0.559
_exptl_absorpt_correction_type   integration
_exptl_absorpt_correction_T_min  0.7787
_exptl_absorpt_correction_T_max  0.9859
_exptl_absorpt_process_details   'X-red ver. 1.31 (Stoe & Cie. 2005)'

_exptl_special_details           
; 
 ? 
;

_diffrn_ambient_temperature      120(2)
_diffrn_measurement_device       '2-circle goniometer'
_diffrn_measurement_device_type  'STOE IPDS 2'
_diffrn_detector                 'image plate (34 cm diameter)'
_diffrn_detector_type            STOE
_diffrn_detector_area_resol_mean 6.67
_diffrn_source                   
'sealed X-ray tube, 12 x 0.4 mm long-fine focus'
_diffrn_source_voltage           50
_diffrn_source_current           30
_diffrn_source_power             1.50
_diffrn_radiation_type           'Mo K\a'
_diffrn_radiation_wavelength     0.71073
_diffrn_radiation_monochromator  'plane graphite'
_diffrn_radiation_polarisn_norm  0
_diffrn_radiation_collimation    '0.5 mm diameter, multiple pinhole'
_diffrn_measurement_method       'rotation method'
_diffrn_measurement_details      
; 212 frames, detector distance = 135 mm
;

_diffrn_standards_decay_%        0
_diffrn_reflns_number            8101
_diffrn_reflns_av_R_equivalents  0.0728
_diffrn_reflns_av_sigmaI/netI    0.0496
_diffrn_reflns_limit_h_min       -8
_diffrn_reflns_limit_h_max       8
_diffrn_reflns_limit_k_min       -12
_diffrn_reflns_limit_k_max       13
_diffrn_reflns_limit_l_min       -16
_diffrn_reflns_limit_l_max       17
_diffrn_reflns_theta_min         1.41
_diffrn_reflns_theta_max         25.18
_reflns_number_total             3779
_reflns_number_gt                3262
_reflns_threshold_expression     >2sigma(I)

_computing_data_collection       ?
_computing_cell_refinement       ?
_computing_data_reduction        ?
_computing_structure_solution    'SHELXS-97 (Sheldrick, 1990)'
_computing_structure_refinement  'SHELXL-97 (Sheldrick, 1997)'
_computing_molecular_graphics    ?
_computing_publication_material  ?

_refine_special_details          
; 
 Refinement of F^2^ against ALL reflections.  The weighted R-factor wR and 
 goodness of fit S are based on F^2^, conventional R-factors R are based 
 on F, with F set to zero for negative F^2^. The threshold expression of 
 F^2^ > 2sigma(F^2^) is used only for calculating R-factors(gt) etc. and is 
 not relevant to the choice of reflections for refinement.  R-factors based 
 on F^2^ are statistically about twice as large as those based on F, and R- 
 factors based on ALL data will be even larger. 
;

_refine_ls_structure_factor_coef Fsqd
_refine_ls_matrix_type           full
_refine_ls_weighting_scheme      calc
_refine_ls_weighting_details     
'calc w=1/[\s^2^(Fo^2^)+(0.1139P)^2^+0.0298P] where P=(Fo^2^+2Fc^2^)/3'
_atom_sites_solution_primary     direct
_atom_sites_solution_secondary   difmap
_atom_sites_solution_hydrogens   geom
_refine_ls_hydrogen_treatment    constr
_refine_ls_extinction_method     none
_refine_ls_extinction_coef       ?
_refine_ls_number_reflns         3779
_refine_ls_number_parameters     208
_refine_ls_number_restraints     0
_refine_ls_R_factor_all          0.0572
_refine_ls_R_factor_gt           0.0522
_refine_ls_wR_factor_ref         0.1574
_refine_ls_wR_factor_gt          0.1532
_refine_ls_goodness_of_fit_ref   1.058
_refine_ls_restrained_S_all      1.058
_refine_ls_shift/su_max          0.000
_refine_ls_shift/su_mean         0.000

loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_symmetry_multiplicity
_atom_site_calc_flag
_atom_site_refinement_flags
_atom_site_disorder_assembly
_atom_site_disorder_group
C1 C 0.2176(3) 0.3706(2) 0.27538(15) 0.0337(5) Uani 1 1 d . . .
C2 C 0.2511(3) 0.2395(2) 0.30221(15) 0.0325(5) Uani 1 1 d . . .
H2A H 0.1262 0.1858 0.3205 0.039 Uiso 1 1 calc R . .
C3 C 0.2398(3) 0.2111(2) 0.19551(15) 0.0343(5) Uani 1 1 d . . .
C4 C 0.0502(3) 0.1122(2) 0.14717(16) 0.0391(5) Uani 1 1 d . . .
H4A H -0.0574 0.1050 0.1838 0.047 Uiso 1 1 calc R . .
H4B H 0.0768 0.0275 0.1429 0.047 Uiso 1 1 calc R . .
C5 C -0.0190(4) 0.1513(2) 0.04906(16) 0.0397(5) Uani 1 1 d . . .
H5A H -0.1409 0.0858 0.0187 0.048 Uiso 1 1 calc R . .
H5B H 0.0867 0.1553 0.0118 0.048 Uiso 1 1 calc R . .
C6 C -0.0640(3) 0.2831(2) 0.05279(17) 0.0417(5) Uani 1 1 d . . .
H6B H -0.1065 0.3057 -0.0109 0.050 Uiso 1 1 calc R . .
H6A H -0.1762 0.2770 0.0864 0.050 Uiso 1 1 calc R . .
C7 C 0.1183(3) 0.3903(2) 0.10059(16) 0.0378(5) Uani 1 1 d . . .
H7A H 0.0695 0.4635 0.1194 0.045 Uiso 1 1 calc R . .
C8 C 0.2727(4) 0.4398(2) 0.03780(18) 0.0435(5) Uani 1 1 d . . .
H8A H 0.3306 0.3712 0.0226 0.052 Uiso 1 1 calc R . .
H8B H 0.3790 0.5123 0.0699 0.052 Uiso 1 1 calc R . .
H8C H 0.2067 0.4676 -0.0191 0.052 Uiso 1 1 calc R . .
C9 C 0.4277(3) 0.1941(2) 0.16401(16) 0.0413(5) Uani 1 1 d . . .
H9A H 0.5462 0.2539 0.2006 0.050 Uiso 1 1 calc R . .
H9B H 0.4218 0.2113 0.0986 0.050 Uiso 1 1 calc R . .
H9C H 0.4354 0.1062 0.1726 0.050 Uiso 1 1 calc R . .
C10 C 0.5647(3) 0.3629(2) 0.41580(16) 0.0383(5) Uani 1 1 d . . .
H10A H 0.4791 0.4143 0.4360 0.046 Uiso 1 1 calc R . .
C11 C 0.7170(3) 0.3485(3) 0.49998(18) 0.0452(6) Uani 1 1 d . . .
H11A H 0.7996 0.2962 0.4816 0.054 Uiso 1 1 calc R . .
H11B H 0.6459 0.3070 0.5479 0.054 Uiso 1 1 calc R . .
H11C H 0.8028 0.4332 0.5242 0.054 Uiso 1 1 calc R . .
C12 C 0.6763(4) 0.4349(2) 0.34368(19) 0.0445(6) Uani 1 1 d . . .
H12A H 0.5795 0.4476 0.2911 0.053 Uiso 1 1 calc R . .
H12B H 0.7597 0.3851 0.3227 0.053 Uiso 1 1 calc R . .
H12C H 0.7613 0.5183 0.3711 0.053 Uiso 1 1 calc R . .
C13 C 0.3564(3) 0.1374(2) 0.44628(15) 0.0373(5) Uani 1 1 d . . .
H13A H 0.4783 0.1278 0.4881 0.045 Uiso 1 1 calc R . .
C14 C 0.2338(4) 0.1903(3) 0.50591(17) 0.0440(6) Uani 1 1 d . . .
H14C H 0.1917 0.1290 0.5516 0.053 Uiso 1 1 calc R . .
H14B H 0.1154 0.2040 0.4665 0.053 Uiso 1 1 calc R . .
H14A H 0.3159 0.2717 0.5377 0.053 Uiso 1 1 calc R . .
C15 C 0.2444(3) 0.0056(2) 0.39942(18) 0.0407(5) Uani 1 1 d . . .
H15C H 0.1995 -0.0533 0.4461 0.049 Uiso 1 1 calc R . .
H15B H 0.3337 -0.0270 0.3672 0.049 Uiso 1 1 calc R . .
H15A H 0.1281 0.0125 0.3549 0.049 Uiso 1 1 calc R . .
C16 C 0.6287(4) 0.8149(2) 0.20857(18) 0.0476(6) Uani 1 1 d . . .
H16A H 0.6701 0.8925 0.2523 0.057 Uiso 1 1 calc R . .
Cl1 Cl 0.74511(7) 0.09225(5) 0.34067(4) 0.0374(2) Uani 1 1 d . . .
Cl2 Cl 0.42887(11) 0.70156(7) 0.24466(5) 0.0578(2) Uani 1 1 d . . .
Cl3 Cl 0.55231(10) 0.86082(7) 0.09590(5) 0.0544(2) Uani 1 1 d . . .
Cl4 Cl 0.83640(12) 0.75103(7) 0.21090(6) 0.0639(3) Uani 1 1 d . . .
N1 N 0.2119(3) 0.34242(17) 0.18433(13) 0.0329(4) Uani 1 1 d . . .
N2 N 0.4279(3) 0.23097(17) 0.37359(12) 0.0331(4) Uani 1 1 d . . .
H2 H 0.5059 0.1942 0.3427 0.040 Uiso 1 1 calc R . .
O1 O 0.1894(2) 0.46014(15) 0.31672(12) 0.0418(4) Uani 1 1 d . . .

loop_
_atom_site_aniso_label
_atom_site_aniso_U_11
_atom_site_aniso_U_22
_atom_site_aniso_U_33
_atom_site_aniso_U_23
_atom_site_aniso_U_13
_atom_site_aniso_U_12
C1 0.0300(10) 0.0362(11) 0.0371(11) 0.0018(9) 0.0116(8) 0.0093(9)
C2 0.0320(10) 0.0347(11) 0.0332(11) 0.0007(9) 0.0103(8) 0.0106(9)
C3 0.0384(11) 0.0351(11) 0.0344(11) 0.0017(9) 0.0138(9) 0.0140(9)
C4 0.0457(12) 0.0351(11) 0.0387(12) 0.0026(9) 0.0147(10) 0.0102(10)
C5 0.0422(12) 0.0404(12) 0.0365(12) 0.0021(10) 0.0102(9) 0.0093(10)
C6 0.0378(11) 0.0457(13) 0.0435(12) 0.0023(10) 0.0089(10) 0.0135(10)
C7 0.0388(11) 0.0371(12) 0.0408(12) 0.0036(10) 0.0116(9) 0.0134(9)
C8 0.0470(13) 0.0438(13) 0.0421(13) 0.0096(11) 0.0153(10) 0.0115(11)
C9 0.0421(12) 0.0534(14) 0.0368(12) 0.0019(10) 0.0149(10) 0.0227(11)
C10 0.0340(10) 0.0387(12) 0.0425(12) -0.0054(10) 0.0093(9) 0.0093(9)
C11 0.0384(12) 0.0504(14) 0.0453(13) -0.0082(11) 0.0078(10) 0.0097(11)
C12 0.0380(11) 0.0396(13) 0.0562(15) 0.0013(11) 0.0152(11) 0.0072(10)
C13 0.0340(10) 0.0451(13) 0.0364(11) 0.0089(10) 0.0124(9) 0.0128(10)
C14 0.0399(12) 0.0581(15) 0.0380(12) 0.0049(11) 0.0154(10) 0.0149(11)
C15 0.0367(11) 0.0381(12) 0.0500(13) 0.0107(10) 0.0124(10) 0.0112(9)
C16 0.0544(14) 0.0421(13) 0.0437(13) -0.0017(11) 0.0145(11) 0.0056(11)
Cl1 0.0334(3) 0.0416(3) 0.0410(3) -0.0004(2) 0.0112(2) 0.0141(2)
Cl2 0.0646(4) 0.0508(4) 0.0536(4) 0.0010(3) 0.0238(3) 0.0003(3)
Cl3 0.0570(4) 0.0579(4) 0.0451(4) 0.0037(3) 0.0128(3) 0.0079(3)
Cl4 0.0629(4) 0.0594(5) 0.0725(5) 0.0053(4) 0.0163(4) 0.0191(4)
N1 0.0332(9) 0.0322(9) 0.0366(9) 0.0027(7) 0.0122(7) 0.0106(7)
N2 0.0310(9) 0.0347(9) 0.0361(10) 0.0000(8) 0.0121(7) 0.0094(7)
O1 0.0459(9) 0.0399(9) 0.0452(9) -0.0029(7) 0.0152(7) 0.0173(7)

_geom_special_details            
; 
 All esds (except the esd in the dihedral angle between two l.s. planes) 
 are estimated using the full covariance matrix.  The cell esds are taken 
 into account individually in the estimation of esds in distances, angles 
 and torsion angles; correlations between esds in cell parameters are only 
 used when they are defined by crystal symmetry.  An approximate (isotropic) 
 treatment of cell esds is used for estimating esds involving l.s. planes. 
;

loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
_geom_bond_site_symmetry_2
_geom_bond_publ_flag
C1 O1 1.218(3) . ?
C1 N1 1.362(3) . ?
C1 C2 1.550(3) . ?
C2 N2 1.514(3) . ?
C2 C3 1.582(3) . ?
C2 H2A 1.0000 . ?
C3 N1 1.499(3) . ?
C3 C9 1.528(3) . ?
C3 C4 1.530(3) . ?
C4 C5 1.549(3) . ?
C4 H4A 0.9900 . ?
C4 H4B 0.9900 . ?
C5 C6 1.549(3) . ?
C5 H5A 0.9900 . ?
C5 H5B 0.9900 . ?
C6 C7 1.542(3) . ?
C6 H6B 0.9900 . ?
C6 H6A 0.9900 . ?
C7 N1 1.468(3) . ?
C7 C8 1.539(3) . ?
C7 H7A 1.0000 . ?
C8 H8A 0.9800 . ?
C8 H8B 0.9800 . ?
C8 H8C 0.9800 . ?
C9 H9A 0.9800 . ?
C9 H9B 0.9800 . ?
C9 H9C 0.9800 . ?
C10 C12 1.529(3) . ?
C10 C11 1.537(3) . ?
C10 N2 1.551(3) . ?
C10 H10A 1.0000 . ?
C11 H11A 0.9800 . ?
C11 H11B 0.9800 . ?
C11 H11C 0.9800 . ?
C12 H12A 0.9800 . ?
C12 H12B 0.9800 . ?
C12 H12C 0.9800 . ?
C13 C15 1.528(3) . ?
C13 C14 1.534(3) . ?
C13 N2 1.541(3) . ?
C13 H13A 1.0000 . ?
C14 H14C 0.9800 . ?
C14 H14B 0.9800 . ?
C14 H14A 0.9800 . ?
C15 H15C 0.9800 . ?
C15 H15B 0.9800 . ?
C15 H15A 0.9800 . ?
C16 Cl2 1.769(3) . ?
C16 Cl4 1.775(3) . ?
C16 Cl3 1.778(3) . ?
C16 H16A 1.0000 . ?
N2 H2 0.9300 . ?

loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
_geom_angle_site_symmetry_1
_geom_angle_site_symmetry_3
_geom_angle_publ_flag
O1 C1 N1 132.9(2) . . ?
O1 C1 C2 134.9(2) . . ?
N1 C1 C2 91.92(16) . . ?
N2 C2 C1 121.30(17) . . ?
N2 C2 C3 122.18(16) . . ?
C1 C2 C3 85.93(16) . . ?
N2 C2 H2A 108.4 . . ?
C1 C2 H2A 108.4 . . ?
C3 C2 H2A 108.4 . . ?
N1 C3 C9 113.95(18) . . ?
N1 C3 C4 109.07(17) . . ?
C9 C3 C4 112.18(18) . . ?
N1 C3 C2 85.78(14) . . ?
C9 C3 C2 117.69(18) . . ?
C4 C3 C2 115.27(17) . . ?
C3 C4 C5 110.59(19) . . ?
C3 C4 H4A 109.5 . . ?
C5 C4 H4A 109.5 . . ?
C3 C4 H4B 109.5 . . ?
C5 C4 H4B 109.5 . . ?
H4A C4 H4B 108.1 . . ?
C4 C5 C6 111.13(19) . . ?
C4 C5 H5A 109.4 . . ?
C6 C5 H5A 109.4 . . ?
C4 C5 H5B 109.4 . . ?
C6 C5 H5B 109.4 . . ?
H5A C5 H5B 108.0 . . ?
C7 C6 C5 112.55(19) . . ?
C7 C6 H6B 109.1 . . ?
C5 C6 H6B 109.1 . . ?
C7 C6 H6A 109.1 . . ?
C5 C6 H6A 109.1 . . ?
H6B C6 H6A 107.8 . . ?
N1 C7 C8 110.40(18) . . ?
N1 C7 C6 108.65(19) . . ?
C8 C7 C6 113.2(2) . . ?
N1 C7 H7A 108.2 . . ?
C8 C7 H7A 108.2 . . ?
C6 C7 H7A 108.2 . . ?
C7 C8 H8A 109.5 . . ?
C7 C8 H8B 109.5 . . ?
H8A C8 H8B 109.5 . . ?
C7 C8 H8C 109.5 . . ?
H8A C8 H8C 109.5 . . ?
H8B C8 H8C 109.5 . . ?
C3 C9 H9A 109.5 . . ?
C3 C9 H9B 109.5 . . ?
H9A C9 H9B 109.5 . . ?
C3 C9 H9C 109.5 . . ?
H9A C9 H9C 109.5 . . ?
H9B C9 H9C 109.5 . . ?
C12 C10 C11 109.27(19) . . ?
C12 C10 N2 110.33(18) . . ?
C11 C10 N2 111.50(19) . . ?
C12 C10 H10A 108.6 . . ?
C11 C10 H10A 108.6 . . ?
N2 C10 H10A 108.6 . . ?
C10 C11 H11A 109.5 . . ?
C10 C11 H11B 109.5 . . ?
H11A C11 H11B 109.5 . . ?
C10 C11 H11C 109.5 . . ?
H11A C11 H11C 109.5 . . ?
H11B C11 H11C 109.5 . . ?
C10 C12 H12A 109.5 . . ?
C10 C12 H12B 109.5 . . ?
H12A C12 H12B 109.5 . . ?
C10 C12 H12C 109.5 . . ?
H12A C12 H12C 109.5 . . ?
H12B C12 H12C 109.5 . . ?
C15 C13 C14 112.97(19) . . ?
C15 C13 N2 109.99(18) . . ?
C14 C13 N2 111.54(18) . . ?
C15 C13 H13A 107.4 . . ?
C14 C13 H13A 107.4 . . ?
N2 C13 H13A 107.4 . . ?
C13 C14 H14C 109.5 . . ?
C13 C14 H14B 109.5 . . ?
H14C C14 H14B 109.5 . . ?
C13 C14 H14A 109.5 . . ?
H14C C14 H14A 109.5 . . ?
H14B C14 H14A 109.5 . . ?
C13 C15 H15C 109.5 . . ?
C13 C15 H15B 109.5 . . ?
H15C C15 H15B 109.5 . . ?
C13 C15 H15A 109.5 . . ?
H15C C15 H15A 109.5 . . ?
H15B C15 H15A 109.5 . . ?
Cl2 C16 Cl4 110.23(15) . . ?
Cl2 C16 Cl3 110.59(15) . . ?
Cl4 C16 Cl3 110.24(14) . . ?
Cl2 C16 H16A 108.6 . . ?
Cl4 C16 H16A 108.6 . . ?
Cl3 C16 H16A 108.6 . . ?
C1 N1 C7 131.34(17) . . ?
C1 N1 C3 96.36(17) . . ?
C7 N1 C3 126.90(18) . . ?
C2 N2 C13 110.03(16) . . ?
C2 N2 C10 113.79(16) . . ?
C13 N2 C10 113.65(17) . . ?
C2 N2 H2 106.2 . . ?
C13 N2 H2 106.2 . . ?
C10 N2 H2 106.2 . . ?

_diffrn_measured_fraction_theta_max 0.982
_diffrn_reflns_theta_full        25.18
_diffrn_measured_fraction_theta_full 0.982
_refine_diff_density_max         0.429
_refine_diff_density_min         -0.599
_refine_diff_density_rms         0.122
_database_code_depnum_ccdc_archive 'CCDC 951678'