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Caption : figure s1. schematic diagram of the dynamic, multi-compartmental tno in vitro model of the stomach and small intestine (tim-1). a. stomach compartment; b. pyloric sphincter; c. duodenum compartment; d. peristaltic valve; e. jejunum compartment; f. peristaltic valve; g. ileum compartment; h. ileocecal sphincter; i. stomach secretion; j. duodenum secretion; k. jejunum/ileum secretion; l. pre-filter; m. semi-permeable membrane; n. water absorption; p. ph electrodes; q. level sensors; r. temperature sensor; s. pressure sensor. reprinted from keller et al. (2017) with permission43.

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Caption : figure s2. gastric delivery (♦), ileal delivery (▲) [both expressed as percentage of the ingested meal], and the gastric ph (■) curves as mimicked in tim-1 over time, representing adults.