Additions and corrections

Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin

Richard Amewu, Andrew V. Stachulski, Stephen A. Ward, Neil G. Berry, Patrick G. Bray, Jill Davies, Gael Labat, Livia Vivas and Paul M. O'Neill

Org. Biomol. Chem., 2006, 4, 4431–4436   Amendment published 16th January 2007

The authors regret the following error:

In Fig. 1, the structure of the steroidal tetraoxane was incorrect and the corrected structure is given below:

In addition, the reference to this structure should be as follows:

B. A. Solaja, N. Terzic, G. Pocsfalvi, L. Gerena, B. Tinant, D. Opsenica and W. K. Milhous, J. Med. Chem., 2002, 45, 33313336.

In Scheme 2, the reagents should read as follows: 30% H2O2 (3.2 equiv.), formic acid (16.67 equiv.), CH3CN, 0 C, 4 minutes, 76% yield.

The elaboration of 5a also proceeds if the reaction is run at room temperature with 2 equivalents of 30% hydrogen peroxide in the presence of formic acid.

We note that Opsenica et al. has also produced analogues of (1922) in Scheme 3 by a similar approach and that we inadvertently omitted the reference as follows:

I. Opsenica, N. Terzic, D. Opsenica, W. K. Milhous and B. Solaja, J. Serb. Chem. Soc., 2004, 69, 919922.

The Royal Society of Chemistry apologises for this error and any consequent inconvenience to authors and readers.