# Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry
# This journal is © The Royal Society of Chemistry 2013

#######################################################################
#
#                 Cambridge Crystallographic Data Centre
#                                CCDC 
# 
#######################################################################
# 
#  This CIF contains data from an original supplementary publication
#  deposited with the CCDC, and may include chemical, crystal,
#  experimental, refinement, atomic coordinates,
#  anisotropic displacement parameters and molecular geometry data,
#  as required by the journal to which it was submitted.
#
#  This CIF is provided on the understanding that it is used for bona
#  fide research purposes only. It may contain copyright material
#  of the CCDC or of third parties, and may not be copied or further
#  disseminated in any form, whether machine-readable or not,
#  except for the purpose of generating routine backup copies
#  on your local computer system.
# 
#  For further information on the CCDC, data deposition and
#  data retrieval see:
#                         www.ccdc.cam.ac.uk
#
#  Bona fide researchers may freely download Mercury and enCIFer
#  from this site to visualise CIF-encoded structures and 
#  to carry out CIF format checking respectively.
#
data_str1407

_audit_creation_method           SHELXL-97
_chemical_name_systematic        ?
_chemical_name_common            ?
_chemical_formula_moiety         'C26 H41 N O5 Si'
_chemical_formula_sum            'C26 H41 N O5 Si'
_chemical_compound_source        Synthesis

_symmetry_cell_setting           monoclinic
_symmetry_space_group_name_H-M   'P 21'
_symmetry_int_tables_number      4
_chemical_absolute_configuration syn
_exptl_crystal_recrystallization_method MeCN
_chemical_melting_point          ?

_exptl_crystal_description       Prism
_exptl_crystal_colour            Colorless

_diffrn_ambient_temperature      150.00(14)
_chemical_formula_weight         475.69

loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0181 0.0091 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
N N 0.0311 0.0180 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0492 0.0322 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
Si Si 0.2541 0.3302 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'

loop_
_symmetry_equiv_pos_as_xyz
'x, y, z'
'-x, y+1/2, -z'

_cell_length_a                   8.6842(5)
_cell_length_b                   8.7472(6)
_cell_length_c                   18.5924(13)
_cell_angle_alpha                90.00
_cell_angle_beta                 93.142(6)
_cell_angle_gamma                90.00
_cell_volume                     1410.19(16)
_cell_formula_units_Z            2
_cell_measurement_temperature    150.00(14)
_cell_measurement_reflns_used    3833
_cell_measurement_theta_min      4.76
_cell_measurement_theta_max      72.39
_exptl_crystal_size_max          0.5511
_exptl_crystal_size_mid          0.3504
_exptl_crystal_size_min          0.0747
_exptl_crystal_density_meas      ?
_exptl_crystal_density_diffrn    1.120
_exptl_crystal_density_method    'not measured'
_exptl_crystal_F_000             516
_exptl_absorpt_coefficient_mu    0.997
_exptl_absorpt_correction_type   multi-scan
_exptl_absorpt_correction_T_min  0.3651
_exptl_absorpt_correction_T_max  1.0000
_exptl_absorpt_process_details   ?

_exptl_special_details           
;
?
;
_diffrn_radiation_probe          ?
_diffrn_radiation_type           CuK\a
_diffrn_radiation_wavelength     1.54184
_diffrn_source                   'fine-focus sealed tube'
_diffrn_radiation_monochromator  graphite
_diffrn_measurement_device_type  ?
_diffrn_measurement_method       ?
_diffrn_detector_area_resol_mean ?
_diffrn_standards_number         ?
_diffrn_standards_interval_count ?
_diffrn_standards_interval_time  ?
_diffrn_standards_decay_%        ?
_diffrn_reflns_number            5207
_diffrn_reflns_av_R_equivalents  0.0397
_diffrn_reflns_av_sigmaI/netI    0.0539
_diffrn_reflns_limit_h_min       -2
_diffrn_reflns_limit_h_max       10
_diffrn_reflns_limit_k_min       -9
_diffrn_reflns_limit_k_max       10
_diffrn_reflns_limit_l_min       -22
_diffrn_reflns_limit_l_max       22
_diffrn_reflns_theta_min         4.76
_diffrn_reflns_theta_max         72.39
_reflns_number_total             3833
_reflns_number_gt                3441
_reflns_threshold_expression     >2sigma(I)

_computing_data_collection       ?
_computing_cell_refinement       ?
_computing_data_reduction        ?
_computing_structure_solution    'SHELXS-97 (Sheldrick, 1990)'
_computing_structure_refinement  'SHELXL-97 (Sheldrick, 1997)'
_computing_molecular_graphics    ?
_computing_publication_material  ?

_refine_special_details          
;
Refinement of F^2^ against ALL reflections. The weighted R-factor wR and
goodness of fit S are based on F^2^, conventional R-factors R are based
on F, with F set to zero for negative F^2^. The threshold expression of
F^2^ > 2sigma(F^2^) is used only for calculating R-factors(gt) etc. and is
not relevant to the choice of reflections for refinement. R-factors based
on F^2^ are statistically about twice as large as those based on F, and R-
factors based on ALL data will be even larger.
;

_refine_ls_structure_factor_coef Fsqd
_refine_ls_matrix_type           full
_refine_ls_weighting_scheme      calc
_refine_ls_weighting_details     
'calc w=1/[\s^2^(Fo^2^)+(0.0668P)^2^+4.4512P] where P=(Fo^2^+2Fc^2^)/3'
_atom_sites_solution_primary     direct
_atom_sites_solution_secondary   difmap
_atom_sites_solution_hydrogens   geom
_refine_ls_hydrogen_treatment    mixed
_refine_ls_extinction_method     none
_refine_ls_extinction_coef       ?
_refine_ls_abs_structure_details 'Flack H D (1983), Acta Cryst. A39, 876-881'
_refine_ls_abs_structure_Flack   0.03(9)
_refine_ls_number_reflns         3833
_refine_ls_number_parameters     306
_refine_ls_number_restraints     1
_refine_ls_R_factor_all          0.0862
_refine_ls_R_factor_gt           0.0757
_refine_ls_wR_factor_ref         0.2405
_refine_ls_wR_factor_gt          0.2339
_refine_ls_goodness_of_fit_ref   1.147
_refine_ls_restrained_S_all      1.147
_refine_ls_shift/su_max          0.005
_refine_ls_shift/su_mean         0.001

loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_symmetry_multiplicity
_atom_site_calc_flag
_atom_site_refinement_flags
_atom_site_disorder_assembly
_atom_site_disorder_group
Si1 Si -0.3769(3) -0.0650(3) -0.13427(11) 0.0495(6) Uani 1 1 d . . .
O26 O -0.7373(5) 0.3760(6) -0.2521(2) 0.0365(11) Uani 1 1 d . . .
O20 O -0.5582(4) 0.3697(6) -0.4575(2) 0.0313(10) Uani 1 1 d . . .
N21 N -0.7223(5) 0.3055(7) -0.3728(3) 0.0235(10) Uani 1 1 d . . .
O14 O -0.3123(5) 0.1829(6) -0.3531(2) 0.0347(11) Uani 1 1 d . . .
O27 O -0.9174(5) 0.2306(6) -0.3092(2) 0.0360(11) Uani 1 1 d . . .
C18 C -0.5837(7) 0.3667(8) -0.3935(3) 0.0268(12) Uani 1 1 d . . .
C28 C -1.0237(7) 0.3046(7) -0.5308(3) 0.0279(12) Uani 1 1 d . . .
O2 O -0.3503(6) 0.1100(7) -0.1619(3) 0.0414(12) Uani 1 1 d . . .
C22 C -0.8353(6) 0.2383(7) -0.4268(3) 0.0254(12) Uani 1 1 d . . .
H22 H -0.7841 0.1708 -0.4601 0.031 Uiso 1 1 calc R . .
C23 C -0.7851(6) 0.3104(8) -0.3057(3) 0.0249(12) Uiso 1 1 d . . .
C15 C -0.4655(6) 0.4143(8) -0.3348(3) 0.0285(13) Uani 1 1 d . . .
H15 H -0.5188 0.4686 -0.2974 0.034 Uiso 1 1 calc R . .
C12 C -0.3893(7) 0.2692(8) -0.3009(3) 0.0286(13) Uani 1 1 d . . .
H12 H -0.4702 0.2052 -0.2818 0.034 Uiso 1 1 calc R . .
C29 C -0.9573(7) 0.2611(7) -0.5940(3) 0.0303(14) Uani 1 1 d . . .
H29 H -0.8509 0.2672 -0.5968 0.036 Uiso 1 1 calc R . .
C30 C -1.1826(7) 0.2949(8) -0.5276(4) 0.0351(14) Uani 1 1 d . . .
H30 H -1.2289 0.3227 -0.4856 0.042 Uiso 1 1 calc R . .
C24 C -0.9248(7) 0.3660(8) -0.4677(3) 0.0295(13) Uani 1 1 d . . .
H24A H -0.9900 0.4184 -0.4349 0.035 Uiso 1 1 calc R . .
H24B H -0.8523 0.4398 -0.4851 0.035 Uiso 1 1 calc R . .
C19 C -0.3465(7) 0.5227(9) -0.3651(4) 0.0358(16) Uani 1 1 d . . .
H19A H -0.2745 0.4648 -0.3915 0.054 Uiso 1 1 calc R . .
H19B H -0.2923 0.5755 -0.3262 0.054 Uiso 1 1 calc R . .
H19C H -0.3981 0.5955 -0.3966 0.054 Uiso 1 1 calc R . .
C10 C -0.2740(7) 0.3099(9) -0.2397(3) 0.0345(14) Uani 1 1 d . . .
H10A H -0.1852 0.3586 -0.2594 0.041 Uiso 1 1 calc R . .
H10B H -0.3207 0.3829 -0.2083 0.041 Uiso 1 1 calc R . .
C31 C -1.0468(9) 0.2091(8) -0.6528(4) 0.0395(16) Uani 1 1 d . . .
H31 H -1.0009 0.1792 -0.6946 0.047 Uiso 1 1 calc R . .
C33 C -1.2075(8) 0.2018(9) -0.6489(4) 0.0407(16) Uani 1 1 d . . .
H33 H -1.2690 0.1686 -0.6884 0.049 Uiso 1 1 calc R . .
C25 C -0.9325(7) 0.1471(8) -0.3763(4) 0.0324(15) Uani 1 1 d . . .
H25A H -1.0393 0.1429 -0.3943 0.039 Uiso 1 1 calc R . .
H25B H -0.8935 0.0437 -0.3703 0.039 Uiso 1 1 calc R . .
C32 C -1.2730(8) 0.2439(9) -0.5866(4) 0.0413(17) Uani 1 1 d . . .
H32 H -1.3795 0.2384 -0.5838 0.050 Uiso 1 1 calc R . .
C17 C -0.3960(9) 0.0559(9) -0.3824(4) 0.0434(18) Uani 1 1 d . . .
H17A H -0.3403 0.0112 -0.4204 0.065 Uiso 1 1 calc R . .
H17B H -0.4953 0.0894 -0.4014 0.065 Uiso 1 1 calc R . .
H17C H -0.4089 -0.0187 -0.3454 0.065 Uiso 1 1 calc R . .
C3 C -0.5933(11) -0.0816(12) -0.1258(5) 0.058(2) Uani 1 1 d . . .
C6 C -0.2204(8) 0.1720(10) -0.1958(4) 0.0415(17) Uani 1 1 d . . .
H6 H -0.1828 0.0949 -0.2289 0.050 Uiso 1 1 calc R . .
C11 C -0.0868(9) 0.2147(13) -0.1413(4) 0.054(2) Uani 1 1 d . . .
H11A H -0.0563 0.1246 -0.1137 0.065 Uiso 1 1 calc R . .
H11B H 0.0010 0.2472 -0.1675 0.065 Uiso 1 1 calc R . .
C7 C -0.6775(13) -0.0371(15) -0.1974(5) 0.076(3) Uani 1 1 d . . .
H7A H -0.6595 0.0690 -0.2071 0.113 Uiso 1 1 calc R . .
H7B H -0.7861 -0.0543 -0.1944 0.113 Uiso 1 1 calc R . .
H7C H -0.6396 -0.0982 -0.2355 0.113 Uiso 1 1 calc R . .
C4 C -0.2746(13) -0.0983(15) -0.0450(5) 0.078(3) Uani 1 1 d . . .
H4A H -0.1668 -0.1145 -0.0513 0.117 Uiso 1 1 calc R . .
H4B H -0.3170 -0.1868 -0.0228 0.117 Uiso 1 1 calc R . .
H4C H -0.2872 -0.0108 -0.0147 0.117 Uiso 1 1 calc R . .
C13 C -0.1269(10) 0.3368(15) -0.0915(4) 0.064(3) Uani 1 1 d . . .
H13 H -0.2101 0.3223 -0.0628 0.077 Uiso 1 1 calc R . .
C16 C -0.0475(15) 0.4693(18) -0.0857(7) 0.087(4) Uani 1 1 d . . .
H16A H -0.078(15) 0.55(2) -0.044(7) 0.130 Uiso 1 1 d . . .
H16B H 0.030(16) 0.48(2) -0.124(7) 0.130 Uiso 1 1 d . . .
C1 C -0.6445(13) 0.0264(17) -0.0683(6) 0.085(4) Uani 1 1 d . . .
H1A H -0.5993 -0.0043 -0.0223 0.127 Uiso 1 1 calc R . .
H1B H -0.7548 0.0238 -0.0672 0.127 Uiso 1 1 calc R . .
H1C H -0.6118 0.1284 -0.0790 0.127 Uiso 1 1 calc R . .
C5 C -0.3069(18) -0.2036(14) -0.2006(6) 0.096(4) Uani 1 1 d . . .
H5A H -0.3588 -0.1858 -0.2467 0.144 Uiso 1 1 calc R . .
H5B H -0.3279 -0.3057 -0.1850 0.144 Uiso 1 1 calc R . .
H5C H -0.1978 -0.1910 -0.2043 0.144 Uiso 1 1 calc R . .
C9 C -0.6360(16) -0.2452(16) -0.1072(8) 0.107(5) Uani 1 1 d . . .
H9A H -0.5964 -0.3136 -0.1421 0.161 Uiso 1 1 calc R . .
H9B H -0.7461 -0.2546 -0.1077 0.161 Uiso 1 1 calc R . .
H9C H -0.5922 -0.2704 -0.0602 0.161 Uiso 1 1 calc R . .

loop_
_atom_site_aniso_label
_atom_site_aniso_U_11
_atom_site_aniso_U_22
_atom_site_aniso_U_33
_atom_site_aniso_U_23
_atom_site_aniso_U_13
_atom_site_aniso_U_12
Si1 0.0701(15) 0.0365(12) 0.0418(11) 0.0025(10) 0.0024(9) 0.0083(11)
O26 0.027(2) 0.046(3) 0.038(2) -0.007(2) 0.0116(17) -0.002(2)
O20 0.0188(18) 0.043(3) 0.033(2) 0.003(2) 0.0083(15) 0.0014(19)
N21 0.0081(19) 0.031(3) 0.032(2) -0.004(2) 0.0067(16) -0.0021(19)
O14 0.025(2) 0.038(3) 0.042(2) -0.007(2) 0.0072(18) 0.004(2)
O27 0.030(2) 0.039(3) 0.040(2) -0.002(2) 0.0092(18) -0.009(2)
C18 0.026(3) 0.021(3) 0.033(3) 0.004(3) 0.003(2) -0.002(3)
C28 0.026(3) 0.019(3) 0.038(3) 0.002(3) -0.003(2) -0.003(2)
O2 0.042(3) 0.042(3) 0.040(3) 0.002(2) 0.003(2) 0.006(2)
C22 0.015(2) 0.024(3) 0.038(3) -0.004(3) 0.003(2) 0.000(2)
C15 0.017(2) 0.029(3) 0.039(3) -0.001(3) 0.004(2) -0.002(2)
C12 0.023(3) 0.030(4) 0.033(3) -0.001(3) 0.003(2) -0.001(2)
C29 0.027(3) 0.023(3) 0.042(3) 0.000(3) 0.005(2) 0.001(2)
C30 0.026(3) 0.030(3) 0.050(4) -0.003(3) 0.003(3) -0.002(3)
C24 0.026(3) 0.022(3) 0.040(3) -0.005(3) -0.003(2) 0.000(3)
C19 0.023(3) 0.033(4) 0.051(4) 0.001(3) 0.003(3) -0.006(3)
C10 0.021(3) 0.044(4) 0.039(3) 0.000(3) 0.001(2) -0.004(3)
C31 0.057(4) 0.026(4) 0.035(3) -0.001(3) 0.002(3) 0.005(3)
C33 0.043(4) 0.028(4) 0.049(4) 0.001(3) -0.015(3) -0.006(3)
C25 0.016(3) 0.035(4) 0.048(4) -0.005(3) 0.011(2) -0.008(2)
C32 0.027(3) 0.034(4) 0.061(5) 0.003(4) -0.010(3) -0.008(3)
C17 0.050(4) 0.036(4) 0.044(4) -0.010(3) -0.001(3) 0.006(3)
C3 0.071(6) 0.052(5) 0.050(4) 0.008(4) 0.001(4) -0.018(5)
C6 0.035(4) 0.049(5) 0.040(4) 0.004(4) 0.002(3) 0.001(3)
C11 0.037(4) 0.077(7) 0.049(4) 0.010(5) -0.004(3) 0.004(4)
C7 0.083(7) 0.076(8) 0.066(6) 0.013(6) -0.014(5) -0.021(6)
C4 0.089(7) 0.081(9) 0.062(5) 0.031(6) -0.011(5) 0.006(6)
C13 0.046(4) 0.101(9) 0.043(4) -0.003(5) -0.003(3) -0.001(5)
C16 0.083(8) 0.099(11) 0.076(7) -0.015(7) -0.022(6) -0.015(7)
C1 0.074(7) 0.110(11) 0.073(7) -0.018(7) 0.025(6) -0.010(7)
C5 0.159(13) 0.048(6) 0.084(8) -0.001(6) 0.034(8) 0.027(8)
C9 0.111(10) 0.076(9) 0.133(12) 0.048(9) -0.015(9) -0.035(8)

_geom_special_details            
;
All esds (except the esd in the dihedral angle between two l.s. planes)
are estimated using the full covariance matrix. The cell esds are taken
into account individually in the estimation of esds in distances, angles
and torsion angles; correlations between esds in cell parameters are only
used when they are defined by crystal symmetry. An approximate (isotropic)
treatment of cell esds is used for estimating esds involving l.s. planes.
;

loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
_geom_bond_site_symmetry_2
_geom_bond_publ_flag
Si1 O2 1.636(6) . ?
Si1 C5 1.854(11) . ?
Si1 C4 1.863(9) . ?
Si1 C3 1.900(10) . ?
O26 C23 1.204(7) . ?
O20 C18 1.222(7) . ?
N21 C23 1.388(7) . ?
N21 C18 1.391(7) . ?
N21 C22 1.486(7) . ?
O14 C17 1.420(9) . ?
O14 C12 1.424(7) . ?
O27 C23 1.343(7) . ?
O27 C25 1.445(8) . ?
C18 C15 1.515(8) . ?
C28 C30 1.387(9) . ?
C28 C29 1.391(8) . ?
C28 C24 1.513(8) . ?
O2 C6 1.428(9) . ?
C22 C25 1.523(8) . ?
C22 C24 1.537(9) . ?
C15 C19 1.532(9) . ?
C15 C12 1.549(9) . ?
C12 C10 1.517(8) . ?
C29 C31 1.383(9) . ?
C30 C32 1.388(10) . ?
C10 C6 1.515(11) . ?
C31 C33 1.403(10) . ?
C33 C32 1.369(11) . ?
C3 C1 1.511(15) . ?
C3 C9 1.522(15) . ?
C3 C7 1.533(13) . ?
C6 C11 1.544(10) . ?
C11 C13 1.469(15) . ?
C13 C16 1.350(18) . ?

loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
_geom_angle_site_symmetry_1
_geom_angle_site_symmetry_3
_geom_angle_publ_flag
O2 Si1 C5 110.2(4) . . ?
O2 Si1 C4 111.0(5) . . ?
C5 Si1 C4 109.4(6) . . ?
O2 Si1 C3 104.8(4) . . ?
C5 Si1 C3 111.5(6) . . ?
C4 Si1 C3 109.9(4) . . ?
C23 N21 C18 128.7(5) . . ?
C23 N21 C22 110.0(4) . . ?
C18 N21 C22 120.9(5) . . ?
C17 O14 C12 115.2(5) . . ?
C23 O27 C25 110.0(4) . . ?
O20 C18 N21 118.9(5) . . ?
O20 C18 C15 122.9(5) . . ?
N21 C18 C15 118.0(5) . . ?
C30 C28 C29 118.6(6) . . ?
C30 C28 C24 120.8(6) . . ?
C29 C28 C24 120.5(5) . . ?
C6 O2 Si1 128.5(5) . . ?
N21 C22 C25 99.0(5) . . ?
N21 C22 C24 110.1(5) . . ?
C25 C22 C24 113.8(5) . . ?
O26 C23 O27 122.9(5) . . ?
O26 C23 N21 128.6(5) . . ?
O27 C23 N21 108.5(5) . . ?
C18 C15 C19 110.5(5) . . ?
C18 C15 C12 109.0(5) . . ?
C19 C15 C12 112.0(5) . . ?
O14 C12 C10 108.6(5) . . ?
O14 C12 C15 111.3(5) . . ?
C10 C12 C15 111.3(6) . . ?
C31 C29 C28 121.1(6) . . ?
C28 C30 C32 120.5(7) . . ?
C28 C24 C22 112.0(5) . . ?
C6 C10 C12 112.8(6) . . ?
C29 C31 C33 119.5(6) . . ?
C32 C33 C31 119.5(6) . . ?
O27 C25 C22 103.9(5) . . ?
C33 C32 C30 120.8(6) . . ?
C1 C3 C9 110.1(10) . . ?
C1 C3 C7 108.1(10) . . ?
C9 C3 C7 108.9(9) . . ?
C1 C3 Si1 110.0(7) . . ?
C9 C3 Si1 110.1(9) . . ?
C7 C3 Si1 109.6(6) . . ?
O2 C6 C10 108.2(5) . . ?
O2 C6 C11 112.7(6) . . ?
C10 C6 C11 111.0(7) . . ?
C13 C11 C6 113.3(7) . . ?
C16 C13 C11 122.4(10) . . ?

_diffrn_measured_fraction_theta_max 0.977
_diffrn_reflns_theta_full        72.39
_diffrn_measured_fraction_theta_full 0.976
_refine_diff_density_max         0.408
_refine_diff_density_min         -0.469
_refine_diff_density_rms         0.074



_database_code_depnum_ccdc_archive 'CCDC 917056'