Additions and corrections
Pathophysiology of photoaging of human skin: focus on neutrophils
Feiko Rijken, Rebecca C. M. Kiekens, Edwin van den Worm, Peter L. Lee, Huib van Weelden and Piet L. B. Bruijnzeel
Photochem. Photobiol. Sci., 2006, 5, 184–189 (DOI: 10.1039/b502522b). Amendment published 21st February 2006.
The abstract for this paper should read as follows.
UV-induced skin damage is the result of a complex cascade of events. Many studies have focused on the skin effects induced by UV-B or UV-A separately. Recently a UV-source that emits UV-B and UV-A together in a ratio comparable to daily sunlight has been introduced i.e. solar simulated radiation (SSR). By exposing human skin type I–III to erythemogenic doses of UV (≥1 MED) emitted by a SSR source we have noticed that: (a) neutrophils are initially the main infiltrating cell type in the dermis and (b) these infiltrating cells are a key source of in vivo enzymatically active enzymes such as elastase, matrix metallo proteinase -1 and -9 (MMPs -1 and -9). These enzymes are relevant to the process of photoaging as they break down the extracellular matrix. Keratinocytes and fibroblasts also produce matrix degrading enzymes, but to a lesser extent. Our results indicate a primary role for infiltrating neutrophils in the initial steps of photoaging. This is further supported by the observation that after exposure of skin type VI to physical doses of SSR equivalent to those used for skin types I–III, no neutrophils and neutrophil-derived enzymatic activity were observed, explaining why skin type VI is less susceptible to photoaging than skin types I–III. Statement: Although most of the data referred to have been published, the current perspective in which they are put together is completely novel and has not been published elsewhere.
‘Summary of results’ and ‘Discussion’ are actually subheadings under the heading ‘The ‘neutrophil point of view’: supportive data’.
The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.