Reaction Details

Schöllkopf Bis-Lactim Amino Acid Synthesis

Asymmetric amino acid synthesis via diastereoselective alkylation of the lithiated bis-lactim ether (derived from L-Val and Gly or Ala) by an electrophile. Subsequent acid hydrolysis liberates L-Val-OCH3 and the (R)-α-substituted amino acid ester. When the bis-lactim is generated from D-Val, the (S)-enantiomer forms:

Schöllkopf Bis-Lactim Amino Acid Synthesis

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