Reaction Details

Sharpless Epoxidation

Titanium-catalyzed asymmetric epoxidation of allylic alcohols employing titanium alkoxide, an optically active tartrate ester and an alkyl hydroperoxide. A high degree of enantiomeric purity is attainable having predictable absolute stereochemistry:

Sharpless Epoxidation

Note: The asterisk at a chiral center denotes a preponderance of either the R or S configuration.

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