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Ugi Reaction (Four-Component Condensation, 4CC)

The α-addition of an iminium ion and the conjugate base of a carboxylic acid to an isocyanide, followed by spontaneous rearrangement of the α-adduct to yield an α-aminocarboxamide derivative. Carbonyl compounds and amines, or their condensation products, serve as precursors to the iminium ion. The nature of the product depends primarily on the acid component:

Ugi Reaction (Four-Component Condensation, 4CC)

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