Jeremy Knowles Award 2013 Winner


Professor Ronald T Raines
Professor Ronald T Raines
University of Wisconsin-Madison

For his work illuminating the catalytic mechanism of ribonuclease A, the subsequent transformation of this enzyme into a potent anti-cancer agent and for identifying n to pi star interactions as previously unrecognized forces that stabilize proteins.


About the Winner


Ronald T Raines, Henry Lardy Professor of Biochemistry and Professor of Chemistry, University of Wisconsin-Madison is an expert on the chemical basis for protein structure and function.  His efforts have led to an RNA-cleaving enzyme that is in a multi-site human clinical trial as an anti-cancer agent, revealed that an unappreciated force-the n-to-pi* interaction-stabilizes all proteins, created hyperstable and human-scale synthetic collagens, and established chemical processes to synthesize proteins and convert crude biomass into useful fuels and chemicals.

Dr Raines received ScB degrees in chemistry and biology from the Massachusetts Institute of Technology, and AM and PhD degrees in chemistry from Harvard University under the direction of Jeremy Knowles. After studying biochemistry and biophysics as a Helen Hay Whitney postdoctoral fellow with William Rutter at the University of California, San Francisco, he joined the faculty at Wisconsin.

Dr Raines has received the Pfizer Award in Enzyme Chemistry, Arthur C Cope Scholar Award, and Repligen Corporation Award in the Chemistry of Biological Processes from the American Chemical Society; the Emil Thomas Kaiser Award from the Protein Society; and the Rao Makineni Lectureship from the American Peptide Society. 

Dr Raines is a fellow of the J S Guggenheim Memorial Foundation, American Association for the Advancement of Science, and Royal Society of Chemistry. He has published over 400 papers and abstracts, delivered over 250 invited lectures, and supervised nearly 50 doctoral theses. He also holds over 30 US patents, and founded both Quintessence Biosciences, Inc. and Hyrax Energy, Inc.


Related Links

Link icon Professor Raines' Webpage
University of Wisconsin-Madison


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