Organic Stereochemistry Award 2009 winner
University of Bristol Awarded for his work on the complementary reactivity of boronic esters and boranes towards secondary carbamates to give enantioenriched tertiary alcohols
About the winner
Varinder K. Aggarwal was born in India in 1961 and emigrated to the United Kingdom in 1963. He received his BA (1983) and PhD (1986) from Cambridge University, studying with Dr Stuart Warren.
He then carried out postdoctoral work with Professor Gilbert Stork at Columbia University, NY (1986-1988) before returning to a lectureship at Bath University and in 1991 moved to Sheffield University, where in 1997, he was promoted to Professor of Organic Chemistry. In 2000, he moved to the University of Bristol to take up the Chair of Synthetic Chemistry.
His research interests lie predominantly in the area of asymmetric methodology development and their application in the synthesis of biologically important targets. The novel methodology developed includes catalytic cycles for the asymmetric synthesis of epoxides, aziridines, and cyclopropanes, improved conditions for the Baylis Hillman reaction which enhance substrate scope, and reactions lithiated carbamates with boranes and borate esters which furnish versatile homologated intermediates for further transformations.
These novel processes are underpinned by detailed mechanistic studies in order to establish firmer foundations for further developments. The limits of this methodology are then probed and extended in the exacting and challenging arena of total synthesis of biologically diverse targets.
Varinder Aggarwal's webpage
School of Chemistry at the University of Bristol
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