Pictet-Spengler reaction

Definition: A condensation-cyclisation of a beta-phenethylamine with an aldehyde to give a tetrahydroisoquinoline.

ID: RXNO:0000059


More about the RSC Name Reaction Ontology (RXNO)

Articles referencing this term

Diversity-oriented synthesis of novel polycyclic scaffolds using polymer-bound reagents
Domingo García-Cuadrado, Sofia Barluenga and Nicolas Winssinger, Chem. Commun., 2008 , 4619
DOI: 10.1039/b807869f

Metal-catalyzed reaction of N-(2-indolyl)methyl, N-bis(trimethylsilyl)methyl diazoamides: an entry into the β-carboline ring system
Bao Zhang and Andrew G. H. Wee, Chem. Commun., 2008 , 4837
DOI: 10.1039/b809890e

A critical look at reactions in class I and II gas-expanded liquids using CO2 and other gases
Geoffrey R. Akien and Martyn Poliakoff, Green Chem., 2009 , 11 , 1083
DOI: 10.1039/b904097h