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[null,"         Supplementary Table 1   Informaion on the proeins identified  based on WGGE combined with CapLC-MS/MS"]
["IPI","Gene_Symbol  Protein name","Mass","pI ","GRAVY","TMD","Subcellular location","Molecular_Function","Score","Unique pep.","Peptide sequence"]
["IPI00555161 ","Apob Apolipoprotein B-100",537740,7.05,-0.239,1,"Extracellular space; intracellular membrane-bounded organelle; very-low-density lipoprotein particle \n","A protein that exhibits lipid binding; cholesterol transporter activity (ortholog); heparin binding (ortholog); ",108,7,"R.YIAELLK.K,K.FGNNPVSK.G,R.SPSSSDINK.I,K.LLLNGAQTFR.G,K.VASNFPVDLSR.Y,K.SVSIPLFDPVSAK.I,K.IAQDGVSTSATTNLK.Y"," "]
["IPI00369995 ","Lrp1 similar to low density lipoprotein receptor-related protein 1",523489,5.14,-0.507,1,"Endoplasmic reticulum By similarity; Cytoplasm By similarity; Cell surface","Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.\n",78,6,"R.SGFSLGSDGK.S,R.TVLVSSGLREPR.A,R.TTLLAGDIEHPR.A,R.YVVISQGLDKPR.A,K.LYFSDATLDKIER.C,R.IFFSDIHFGNIQQINDDGSGR.T"," "]
["IPI00767694","Sptbn5 similar to Spectrin beta chain, brain 4",408187,5.82,-0.548,1,"Protein complex; apical cortex (ortholog); cortical cytoskeleton (ortholog)","A protein that exhibits actin filament binding (ortholog); dynactin binding (ortholog); dynein intermediate chain binding (ortholog); INVOLVED IN Golgi organization (ortholog); lysosomal transport (ortholog); protein homooligomerization (ortholog); ",41,1,"K.VLHLQR.M"]
["IPI00190024","Acacb Acetyl-Coenzyme A carboxylase 2",276100,5.84,-0.216,1,"Mitochondrion; nucleus","Acetyl-CoA carboxylase activity; ATP binding; biotin binding",42,1,"R.MGLSEEIK.Q"]
["IPI00200661","Fasn Fatty acid synthase",275101,5.96,-0.063,0,"Cytoplasm (By similarity); Melanosome (By similarity)","Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.",55,5,"R.TGTVPLEVR.L,R.VAAAVDLITR.S,K.AGSDTELAAPK.S,K.LDPGSSELQK.V,R.VTAIYIDPATHLQK.V"," "]
["IPI00194766","Myo7a Myosin VIIA",252779,8.8,-0.437,0,"Apical plasma membrane;cytoplasm;lysosomal membrane;melanosome","ADP binding,ATP binding,actin binding,actin-dependent ATPase activity,calmodulin binding,microfilament motor activity,motor activity,protein complex binding,Inferred from direct assay,protein homodimerization activity.",51,1,"R.GETVSTPLSR.E "]
["IPI00367479","Myh14 myosin, heavy chain 14",228914,5.49,-0.783,0,"Actomyosin (ortholog); axon (ortholog); cytoplasm (ortholog)","A protein that exhibits actin filament binding (ortholog); actin-dependent ATPase activity (ortholog); ATP binding (ortholog); INVOLVED IN actin filament-based movement (ortholog); actomyosin structure organization (ortholog); ATP catabolic process (ortholog); PARTICIPATES IN myocarditis pathway; ",64,1,"K.EQADFALEALAK.A"," "]
["IPI00764167","Myh11 similar to Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC) isoform 3",228762,5.41,-0.835,0,"Melanosome By similarity; Cytoplasm › myofibril ","Muscle contraction.",105,4,"R.VLGQAK.Q,K.RQQQLTAMK.V,K.EQADFAIEALAK.A,R.NTDQASMPDNTAAQK.V"," "]
["IPI00209113 ","Myh9 Myosin-9",227566,5.49,-0.832,0,"Cytoplasm › cytoskeleton; Cytoplasm › cell cortex ","A protein that exhibits follicle-stimulating hormone receptor binding; protein kinase binding; actin filament binding (ortholog); ",262,14,"R.NCAAYLR.L,R.VVFQEFR.Q,R.HEDELLAK.E,K.RQQQLTAMK.V,K.VVQEQGTHPK.F,K.ALELDSNLYR.I,K.EQADFAIEALAK.A,R.TVGQLYKEQLAK.L,K.VIQYLAHVASSHK.S,K.VSHLLGINVTDFTR.G,R.NTDQASMPDNTAAQK.V,K.QFRTEMEDLMSSK.D + 2 Oxidation (M),K.NLPIYSEEIVDMYK.G,K.ANLQIDQINTDLNLER.S\n"," "]
["IPI00768002","LOC683404 similar to Retinitis pigmentosa 1-like 1 protein  ",203187,5.85,-0.781,0,"Axoneme (ortholog); extracellular vesicular exosome (ortholog); photoreceptor connecting cilium (ortholog)","INVOLVED IN photoreceptor cell development (ortholog); photoreceptor cell maintenance (ortholog); ASSOCIATED WITH OCCULT MACULAR DYSTROPHY (ortholog);",44,2,"R.GDPVLR.L,R.GDPVLR.L"," "]
["IPI00480639","C3 Complement C3 (Fragment)",187825,6.12,-0.275,1,"Extracellular space; blood microparticle (ortholog); extracellular vesicular exosome (ortholog);","A protein that exhibits cofactor binding; lipid binding; C5L2 anaphylatoxin chemotactic receptor binding (ortholog); ",263,18,"R.VGLVAVDK.G,K.WLILEK.Q,R.IEGNQGAR.V,R.NEQVEIR.A,K.LSVNTPNNR.Q,R.LITQGESCLK.A,R.VTIKPAPETAK.K,R.LLWESGSLLR.S,K.SSMILDICTR.Y + Oxidation (M),K.SGSDEVQAGQER.R,K.SSVAVPYVIVPLK.I,R.IFTVDNNLLPVGK.T,R.VLIEDGSGEAVLSR.K,R.DNRQPAPGHQTTLR.I,R.SEETKQNEGFSLTAK.G,R.SDVDEDIIPEEDIISR.S,R.RVPVVTQGSDAQALTQDDGVAK.L\n"," "]
["IPI00205519","Ugcgl1 UDP-glucose:glycoprotein glucosyltransferase 1",177219,5.43,-0.317,1,"Endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum (ortholog) ","Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. ",87,5,"K.TAVSAQLR.A,R.TDLKELR.D,R.ISMINNPSR.E + Oxidation (M),R.EISDSSTPVSR.A,K.ILETTTFFQR.A"," "]
["IPI00869708","Mrc1 mannose receptor, C type 1",168717,6.5,-0.486,2,"Cell surface (ortholog); endosome membrane (ortholog); plasma membrane (ortholog) ","Mannose binding,transmembrane signaling receptor activity.",152,6,"K.AIGGELASIK.S,R.GVHYTNWGK.G,K.GTELYFNYGNR.Q,K.YFWTGLSDVQNK.G,R.YLNWLPGSPSSEPGK.S,R.RSSLSYEDVDCVVVIGGNSR.E"," "]
["IPI00326140","Pzp Alpha-1-macroglobulin",168388,6.46,-0.183,0,"Extracellular space (inferred)"," A protein that exhibits protein complex binding; INVOLVED IN embryo implantation (inferred); negative regulation of endopeptidase activity (inferred);",42,4,"K.NVEENVR.E,R.LADLPGNYITK.V,K.AISYLISGYQR.Q,R.GSIFNSGSHVLPLEQGK.V"," "]
["IPI00212666","Mug2;Mug1;LOC297568 Isoform 1 of Murinoglobulin-1",166590,5.68,-0.222,0,"Extracellular space (inferred)","A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective.",62,3,"K.YGAATFSK.S,K.VLIVEPEGIKK.E,R.LTAQPAPSPEDLALSMGTIK.W"," "," "]
["IPI00368704 ","RGD1566313 similar to Murinoglobulin 1 homolog   ",166177,6.63,-0.224,0,"Unknown","Unknown",60,1,"K.YGAATFSK.S"]
["IPI00210644","Cps1 Carbamoyl-phosphate synthase [ammonia], mitochondrial",165673,6.33,-0.117,0,"Cytoplasm; mitochondrial inner membrane; mitochondrion","INVOLVED IN anion homeostasis; cellular response to cAMP; cellular response to fibroblast growth factor stimulus;",1237,43,"R.TSINVVR.H, R.DELGLNK.Y, K.EIGFSDK.Q, R.DKGTMLGK.I +Oxidation(M), R.FLEEATR.V, K.LFAEAVQK.A, K.VVAVDCGIK.N, K.APMFSWPR.L, R.GVLKEYGVK.V, R.EVEMDAVGK.E +Oxidation(M), K.ELSEPSSTR.I, K.APMFSWPR.L + Oxidation (M), R.TFEESFQK.A, K.SVGEVMAIGR.T + Oxidation(M), R.LRDADPILR.C, K.VPAIYGVDTR.M, K.VMIGESVDEK.H + Oxidation(M), K.CLGLTEAQTR.E, K.IALGIPLPEIK.N, R.SIFSAVLDELK.V, K.ATGYPLAFIAAK.I, K.IMGTSPLQIDR.A, R.VSQEHPVVLTK.F, K.IMGTSPLQIDR.A + Oxidation (M),K.TLGVDFIDVATK.V, K.AADTIGYPVMIR.S, K.AMLSTGFKIPQK.G + Oxidation(M), R.GQNQPVLNITNR.Q, K.AQTAHIVLEDGTK.M, K.AFAMTNQILVER.S, R.MCHPSVDGFTPR.L + Oxidation(M), K.GLNSESVTEETLR.Q, K.ALENNMSLDEIVK.L, R.SAYALGGLGSGICPNK.E, R.FLGVAEQLHNEGFK.L, K.IAPSFAVESMEDALK.A, K.AFAISGPFNVQFLVK.G, R.DGSIDLVINLPNNNTK.F, R.TAVDSGIALLTNFQVTK.L, K.TVLMNPNIASVQTNEVGLK.Q, K.HLPTLEQPIIPSDYVAIK.A, K.TVLMNPNIASVQTNEVGLK.Q + Oxidation (M), K.QADAVYFLPITPQFVTEVIK.A\n"," "]
["IPI00201262","Mug2;Mug1;LOC297568 Alpha-1-inhibitor 3",165038,5.7,-0.216,0,"Blood microparticle (ortholog); extracellular vesicular exosome (ortholog) ","Protease inhibitor with a wide spectrum of protein targets, which attaches through its thioester function.",65,5,"K.YGAATFSK.S,K.VLIVEPEGIKK.E,K.ISLCHGNPTFSSETK.S,R.LVDIKGDPIPNEQVLIK.A,R.LTAQPAPSPEDLALSMGTIK.W\n"," "]
["IPI00365744","Nomo1 nodal modulator 1",134442,5.73,-0.151,0,"Endoplasmic reticulum membrane (ortholog)","A protein that exhibits carbohydrate binding (inferred); ",60,3,"K.ITVTPSSK.E,K.IQSTVTQPGGK.F,K.VQVVVPEAETR.A"," "," "]
["IPI00363547","Fhod1 similar to FH1/FH2 domain-containing protein",129290,5.8,-0.302,0,"Cytoplasm (ortholog); membrane (ortholog); nucleus (ortholog) ","A protein that exhibits identical protein binding (ortholog); ",40,1,"M.AGEEERGDGDPVSVVTVR.V"," "]
["IPI00454251","Hsd11b1 LRRGT00065",128542,9.7,-0.537,0,"Apical part of cell; cytoplasm; intracellular membrane-bounded organelle","A protein that exhibits 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity; NADP binding; oxidoreductase activity;",358,11,"R.GLISK.I,R.IMEFLSLR.S,R.KDEVYYDK.S,K.EECALEIIK.G,K.FALDGFFSTIR.K,K.ETSGIILSQAAPK.E,-.MTQPLIASYSASK.F,\nK.SSWTPLLLGNPGR.R,K.FALDGFFSTIRK.E,-.MTQPLIASYSASK.F + Oxidation (M),K.SSWTPLLLGNPGRR.I\n "," "]
["IPI00325847","Cp GPI-anchored ceruloplasmin",124469,5.39,-0.482,0,"Anchored component of plasma membrane; extracellular space; blood microparticle (ortholog)","A protein that exhibits copper ion binding; chaperone binding (ortholog); ferroxidase activity (ortholog); ",49,1,"R.VFFEQGATR.I"]
["IPI00476292","Cp 121 kDa protein",121458,5.35,-0.49,0,"Anchored component of plasma membrane;extracellular space","Copper ion binding,ferroxidase activity",47,2,"R.VFFEQGATR.I,K.SSTVAPTLPGEVR.T"," "]
["IPI00365705","Atp4a similar to Potassium-transporting ATPase alpha chain 1",115745,5.58,0.061,8,"Cell membrane; Multi-pass membrane protein\n","Catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. Responsible for acid production in the stomach.\n",41,2,"K.KAGGGGGK.K,K.TGTLTQNR.M"," "]
["IPI00188119","Atp12a Isoform Long of Potassium-transporting ATPase alpha chain 2",115643,6.16,0.034,8,"Membrane; Multi-pass membrane protein\n","Catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. Responsible for potassium absorption in various tissues.\n",46,1,"K.TGTLTQNR.M"]
["IPI00390795","Atp1a4 ATPase, Na+/K+ transporting, alpha 4 polypeptide",115260,5.55,0.034,10,"Membrane;integral component of membrane","ATP binding,metal ion binding,sodium:potassium-exchanging ATPase activity",46,1,"K.TGTLTQNR.M"]
["IPI00555265","Nnt Nicotinamide nucleotide transhydrogenase",114537,8.02,0.274,12,"Integral component of membrane;mitochondrial inner membrane","NAD(P)+ transhydrogenase (AB-specific) activity,NADP binding",308,16,"K.SMGAVVR.G + Oxidation (M),R.AAALEQFK.S,K.TCDALQAK.V,K.SAPLLLPGR.H,R.AAGAQIQGTK.E,K.TVAELEAEK.A,\nK.EIFQNEKR.V,K.EVLASDLVVK.V,K.ESGEGQGGYAK.E,K.AQYPIADLVK.M,R.FFTGQITAAGK.V,K.TTVLAMDQVPR.V + Oxidation (M),R.VALSPAGVQALVK.Q,K.DGNVIFPAPTPK.N,K.GITHIGYTDLPSR.M,K.ILIVGGGVAGLASAGAAK.S\n"," "]
["IPI00326305","Atp1a1 Sodium/potassium-transporting ATPase subunit alpha-1",114293,5.3,0.002,10,"Cell membrane; Multi-pass membrane protein; Melanosome (By similarity) ","This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. ",70,3,"K.TGTLTQNR.M,R.SPDFTNENPLETR.N,R.QGAIVAVTGDGVNDSPALK.K"," "]
["IPI00359123","RGD1310427 hypothetical protein LOC362643",111940,5.3,0.002,10,"ER membrane protein complex (ortholog); integral component of membrane (ortholog)","INTERACTS WITH furan; 2,3,7,8-tetrachlorodibenzodioxine (ortholog); 5-fluorouracil (ortholog)",43,4,"K.LVVATEK.N,R.TGEILWR.H,K.NVIAALNSR.T,R.SQIKNEINIDTLAR.D"," "]
["IPI00210975","Hyou1 Hypoxia up-regulated protein 1",111448,5.3,0.002,10,"Endoplasmic reticulum lumen","Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding (By similarity). ",44,6,"R.AVLQAAR.M,K.LFNEQR.K,R.EVEEEPGLR.S,K.EAGTQPQLQIR.G,K.VAIVKPGVPMEIVLNK.E,R.SRFPEHELNVDPQR.Q\n"," "]
["IPI00201333 ","Ganab 109 kDa protein    ",109819,5.69,-0.337,1,"Extracellular vesicular exosome (ortholog);  membrane (ortholog)","INVOLVED IN carbohydrate metabolic process (inferred); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; N-linked glycan biosynthetic pathway; ",124,13,"R.GGTIVPR.W,R.AFFSGSQR.F,R.SLLLSVNAR.G,K.VTEGGEPYR.L,K.NPEPELLVR.W,R.LKVTEGGEPYR.L,R.SGGIERPFVLSR.A,\nK.DAVHYGGWEHR.D,R.VVIMGAGKPAAVVLQTK.G + Oxidation (M),R.LSFQHDPETSVLTLR.K,R.REPWLLASQYQDAIR.D,\nR.DIHNIYGLYVHMATADGLIQR.S + Oxidation (M)\n"," "]
["IPI00471608","Snd1 Staphylococcal nuclease domain-containing protein 1",102573,6.76,-0.429,0,"Cytoplasm; Nucleus; Melanosome","Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Plays a role in cell viability. Functions as a transcriptional coactivator for STAT5. Plays a role in cell viability.",78,4,"K.LNSGDYK.T,R.VADISGDTQK.A,R.SDISSHPPVEGAYAPR.R,K.VSVTVDYIRPASPATETVPAFSER.T\n"," "]
["IPI00368742","RGD1309926 similar to neutrophil cytosolic factor 1  ",101551,8.95,-0.822,0,"Cytoplasm (ortholog); podosome (ortholog)","A protein that exhibits phosphatidylinositol-3,5-bisphosphate binding (ortholog); phosphatidylinositol-3-phosphate binding (ortholog); phosphatidylinositol-4-phosphate binding (ortholog); ",48,1,"R.QDGLSPK.E"]
["IPI00192076","100 kDa protein  ",101087,6.45,-0.027,0,"Nucleus","RNA binding,ubiquitin-protein transferase activity,zinc ion binding",48,2,"R.IFHELTQTDK.A,K.YVVVTGITPTPLGEGK.S"," "]
["IPI00196725","Aldh1l1 10-formyltetrahydrofolate dehydrogenase",99976,5.79,-0.147,0,"Cytoplasm","Aldehyde dehydrogenase (NADP+) activity,aldehyde dehydrogenase [NAD(P)+] activity,formyltetrahydrofolate dehydrogenase activity,hydroxymethyl-, formyl- and related transferase activity,methyltransferase activity,protein complex binding",150,6,"R.LIAEGTAPR.C,R.EFIQLLVR.K,K.EESFGPIMIISR.F,R.ANATEFGLASGVFTR.D,R.ILPNVPEVEDSTDFFK.S,\nK.GSASSDLELTEAELATAEAVR.S\n"," "]
["IPI00212316","Mttp microsomal triglyceride transfer protein",99752,7.54,-0.143,0,"Golgi apparatus;basolateral plasma membrane;brush border membrane;membrane-bounded vesicle;microvillus membrane;\nrough endoplasmic reticulum","Apolipoprotein binding,lipid transporter activity,protein heterodimerization activity",376,16,"K.TTEAGPR.M,K.LQDSVGYR.I,K.VTYQAQQDK.V,K.IVGKDNLEALR.R,R.SNLNIFQYIGK.A,K.MLSASGDPVSVVK.G + Oxidation (M),\nK.SGSSSAYTGYVER.S,R.AFALNFLQTVAGK.I,K.NALLPEGIPLLLK.Y,K.VTYQAQQDKVVK.I,R.YDASFITDEVKK.T,\nK.LTYSTEVFLDGGK.G,R.SGFTTANQVLGVTSK.A,K.IEDSFVTAVVAEETR.A,K.EFYSYENEPVGIENLKR.G,\nR.NPDGDDDQLIQVTITAVNVENAGQQR.G\n"," "]
["IPI00202370","Maoa similar to Amine oxidase [flavin-containing] A",98754,8.12,-0.237,0,"Mitochondrial outer membrane; mitochondrion (ortholog)","Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.\n",48,3,"R.EVLNALGK.V,K.INVLVLEAR.D,K.WVDVGGAYVGPTQNR.I"," "]
["IPI00206780 ","Plg Plasminogen",93214,6.79,-0.697,0,"Extracellular space;extrinsic component of external side of plasma membrane;intracellular membrane-bounded organelle;\nplasma membrane","Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. ",58,2,"R.IFTPQTNPR.A,R.ILGSDVQQIAVTK.L"," "]
["IPI00365985","Tra1 Isoform 1 of Endoplasmin",92998,4.72,-0.732,0,"Endoplasmic reticulum lumen;Melanosome ","Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. ",924,28,"K.SDYIK.L,K.AVVSQR.L,R.FQNVAK.E,K.YLNFVK.G,K.AQAYQTGK.D,K.TFEINPR.H,R.ETLQQHK.L,K.NKEIFLR.E,K.LIINSLYK.N,\nK.AYGDRIER.M,K.SGTSEFLNK.M,R.SGYLLPDTK.A,K.FAFQAEVNR.M,K.LGVIEDHSNR.T,K.EAESSPFVER.L,K.SILFVPTSAPR.G,\nR.KEAESSPFVER.L,K.DISTNYYASQKK.T,K.GVVDSDDLPLNVSR.E,K.EEASDYLELDTIK.N,K.NLLHVTDTGVGMTR.E + Oxidation (M),\nR.ELISNASDALDKIR.L,K.EVEEDEYKAFYK.S,K.YSQFINFPIYVWSSK.T,R.KYSQFINFPIYVWSSK.T,R.LISLTDENALAGNEELTVK.I,\nK.AQAYQTGKDISTNYYASQK.K,R.TDDEVVQREEEAIQLDGLNASQIR.E\n"," "]
["IPI00199641","Gcs1 Mannosyl-oligosaccharide glucosidase",91986,9.07,-0.27,1,"Endoplasmic reticulum membrane; Single-pass type II membrane protein","Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner.",138,4,"R.ANVVSNVR.Q,R.LGPLLDVLADSR.H,R.LTLLPPTTPGDTVPK.H,R.GFLWDEGFHQLVVQR.W\n"," "]
["IPI00191681","Itgb1 Integrin beta-1",91687,5.77,-0.374,1,"Cell membrane; Single-pass type I membrane protein; Melanosome ","A protein that exhibits actin binding; alpha-actinin binding; collagen binding;",42,3,"R.IGFGSFVEK.T,K.SAVTTVVNPK.Y,K.TVMPYISTTPAK.L"," "]
["IPI00359647","H6pd hexose-6-phosphate dehydrogenase",90410,6.77,-0.184,0,"Cytoplasm;intracellular membrane-bounded organelle;mitochondrion","6-phosphogluconolactonase activity,NADP binding,carbohydrate binding,glucose-6-phosphate dehydrogenase activity",42,1,"R.EITTLVSR.V"]
["IPI00212014","Vcp Transitional endoplasmic reticulum ATPase",90162,5.14,-0.351,0,"Cytoplasm; cytosol;Nucleus; Endoplasmic reticulum (By similarity)","Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168- dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. ",71,3,"R.GILLYGPPGTGK.T,K.NAPAIIFIDELDAIAPK.R,R.LIVDEAINEDNSVVSLSQPK.M"," "]
["IPI00205606","Sel1l Protein sel-1 homolog 1",89140,5.4,-0.382,2,"Endoplasmic reticulum membrane (inferred); integral component of membrane (inferred) ","May play a role in Notch signaling. May be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin- dependent degradation of misfolded endoplasmic reticulum proteins. ",66,1,"R.AASQGYTVAR.I"]
["IPI00213538","Cpt1a Carnitine O-palmitoyltransferase 1, liver isoform",88810,8.77,-0.245,1," Integral component of membrane; integral component of mitochondrial outer membrane; intracellular membrane-bounded organelle "," A protein that exhibits carnitine O-palmitoyltransferase activity; identical protein binding;",122,8,"R.LPVPAVK.D,K.QSLDAVEK.A,K.EVLSEPWR.L,K.YLAVDSPFLK.E,R.LPVPAVKDTVSR.Y,K.LAALTAADRVPWAK.C,\nR.MTALAQDFAVNLGPK.L,R.LLGSTIPLCSAQWER.L\n"," "]
["IPI00208422","Dpp4 Dipeptidyl peptidase 4",88774,5.93,-0.354,1,"Cell membrane; Single-pass type II membrane protein; Apical cell membrane","Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones (By similarity). Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N- termini provided that the penultimate residue is proline. ",161,11,"K.AGAVNPTVK.F,R.ISLQWLR.R,R.STDQKELR.V,R.VLEDNSALDK.M,K.MLQDVQMPSK.K + Oxidation (M),\nK.MLQDVQMPSK.K + 2 Oxidation (M),R.GPGLPLYTLHR.S,R.LFVLLEYNYVK.Q,R.LGTLEVEDQIEAAR.Q,\nR.YMGLPTPEDNLDHYR.N + Oxidation (M),R.LNWATYLASTENIIVASFDGR.G\n"," "]
["IPI00557975","Acad11 Acyl-CoA dehydrogenase family member 11",88057,8.4,-0.21,0,"Peroxisome; Mitochondrion ","Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA. ",415,19,"R.SVGLAER.I,R.IAIEEIR.L,R.QVSTWTK.Q,R.TESPSVSR.H,R.GFEISQGR.L,K.GSQAYVLR.K,R.RGQEVLTR.V,K.MELQDQAR.Q,\nR.AVLTVTQYR.S,K.LAGIAQGVYSR.Y,R.DTVEVLPQHK.F,K.QQWLEPLLR.G,R.VPASNLILGEGR.G,R.TLSTVPPQADAK.S,\nR.DFSIPGVSPAER.A,K.AAHSIDTLGSAAAR.K,R.SGQSNPTFFLQK.G,R.LADGPDEVHLSAIAK.M,R.IFRDFSIPGVSPAER.A\n"," "]
["IPI00373136","Ankrd5 ankyrin repeat domain 5",87540,8.21,-0.414,0,"Unknown","Calcium ion binding",48,1,"R.IIDMIK.E + Oxidation (M)"," "]
["IPI00210566","Hsp90aa1 Heat shock protein HSP 90-alpha",85161,4.93,-0.745,0,"Cytoplasm (By similarity); Melanosome ","Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function",129,5,"K.YIDQEELNK.T,K.DQVANSAFVER.L,K.ADLINNLGTIAK.S,R.TLTIVDTGIGMTK.A,R.GVVDSEDLPLNISR.E\n"," "]
["IPI00782735","Atp1a1 83 kDa protein",84009,5.6,0.071,7,"Membrane;integral to membrane","ATP binding;monovalent inorganic cation transporter activity;ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism;hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;",89,3,"K.TGTLTQNR.M,R.AVAGDASESALLK.C,R.QGAIVAVTGDGVNDSPALKK.A"," "]
["IPI00768456","Cyp2c37 similar to cytochrome P450-like",83925,6.64,-0.074,0,"Endoplasmic reticulum (inferred); intracellular membrane-bounded organelle (inferred); membrane (inferred) ","a protein that exhibits aromatase activity (inferred); heme binding (inferred); iron ion binding (inferred); ",336,16,"R.QSSGR.G,R.NLGMGKR.N,R.FTLTTLR.N,K.VQEEIDR.V,R.SPCMQDR.S,R.YALLLLLK.Y,R.MCAGEGLAR.M,\nR.MCAGEGLAR.M + Oxidation (M),R.DFIDYYLIK.W,K.VQEEIDRVVGK.H,K.EHQESLDVTNPR.D,K.EALIDHGEEFAER.G,\nR.MPYTDAMIHEVQR.F,K.IKEHQESLDVTNPR.D,R.FDYKDQDFLNLMEK.L,R.FIDLIPTNLPHAVTCDIK.F\n"," "]
["IPI00471584","Hsp90ab1 Heat shock protein HSP 90-beta",83571,4.96,-0.678,0,"Cytoplasm; Melanosome ","Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function",171,8,"K.FYEAFSK.N,R.ADHGEPIGR.G,K.LGIHEDSTNR.R,K.YIDQEELNK.T,K.ADLINNLGTIAK.S,R.TLTLVDTGIGMTK.A,\nR.GVVDSEDLPLNISR.E,R.NPDDITQEEYGEFYK.S\n"," "]
["IPI00212622","Hadha Trifunctional enzyme subunit alpha, mitochondrial",83297,9.16,-0.081,0,"Mitochondrion matrix; mitochondrial fatty acid beta-oxidation multienzyme complex;mitochondrial inner membrane;\nmitochondrial nucleoid,mitochondrion;nucleolus\n","Lyase,Oxidoreductase",673,26,"R.INSPNSK.V,R.ISQEGQK.M,R.GQQQVFK.G,R.DLANNSSK.K,K.FGELALTK.E,K.DTTVTGLGR.G,R.THINYGVK.G,R.ILQEGVDPK.K,\nR.FGGGSVELLK.L,K.DGPGFYTTR.C,R.FVDLYGAQK.V,K.DTTASAVAVGLK.Q,K.GFYIYQSGSK.N,K.MQLLEIITTDK.T,\nK.TLLKDTTVTGLGR.G,K.LTSYAMTIPFVR.Q,K.LTSYAMTIPFVR.Q + Oxidation (M),K.MVGVPAAFDMMLTGR.N,\nK.NLNSEIDNILVNLR.L,K.ADMVIEAVFEDLAVK.H,K.MGLVDQLVDPLGPGIK.S,K.ADMVIEAVFEDLAVK.H + Oxidation (M),\nR.LPAKPEVSSDEDIQYR.V,K.TVLGVPEVLLGILPGAGGTQR.L,K.EVQSEFVEVMNEIWANDQIR.S,K.TGLEQGNDAGYLAESEKFGELALTK.E\n"," "]
["IPI00187918","Faah 80 kDa protein   ",81815,8.71,0.128,1,"Membrane","Catalytical activity",54,1,"R.LQNPDLDSEALLTLPLLQLVQK.L"," "]
["IPI00326948","Hsd17b4 Hsd17b4 protein",81551,8.69,-0.08,0,"Peroxisome; intracellular membrane-bounded organelle (ortholog); membrane (ortholog) ","Oxidoreductase activity,sterol binding",524,14,"R.GSFQVTR.A,R.AYALAFAER.G,R.VVLVTGAGGGLGR.A,R.NQPMTPEAVR.D + Oxidation (M),K.LNPQNAFFSGR.L, K.ICDFSNASKPK.S,R.IDVVVNNAGILR.D,K.AVANYDSVEAGEK.L,R.DTTSLNQAALYR.L,R.ISDEDWDIIQR.V,R.GALVVVNDLGGDFK.G,R.HVLQQFADNDVSR.F,K.LGLLGLANTLVIEGR.K,K.SLMSGGLAEVPGLSINFAK.V + Oxidation (M)\n"," "]
["IPI00369217","Trap1 Heat shock protein 75 kDa, mitochondrial",80639,5.62,-0.621,0,"Mitochondrion; Mitochondrion inner membrane; Mitochondrion matrix","Chaperone that expresses an ATPase activity By similarity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I By similarity. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis By similarity. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.",43,1,"R.GVVDSEDIPLNLSR.E"," "]
["IPI00358033","Ndufs1 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial",80331,5.65,-0.101,0,"Mitochondrion inner membrane","Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. ",113,2,"R.DDGAAILAAVSSIAQK.I,R.FASEIAGVDDLGTTGR.G"," "]
["IPI00561647","Hsd17b4 Peroxisomal multifunctional enzyme type 2",79891,8.77,-0.104,0,"Peroxisome;mitochondrion;peroxisomal membrane","Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids.\n",246,9,"R.AYALAFAER.G,R.VVLVTGAGGGLGR.A,K.LNPQNAFFSGR.L,R.IDVVVNNAGILR.D,R.DTTSLNQAALYR.L,K.AVANYDSVEAGEK.L,\nR.ISDEDWDIIQR.V,R.GALVVVNDLGGDFK.G,K.FVYEGSADFSCLPTFGVIVAQK.S\n"," "]
["IPI00232011","Ehhadh Peroxisomal bifunctional enzyme",79179,9.28,-0.107,0,"Peroxisome;cytosol;mitochondrion;nucleus","Isomerase,Lyase,Oxidoreductase",1143,26,"R.SIQASVK.H,R.GTQLLPR.V,R.GIAISFAR.V,R.LLEVIPSR.Y,R.LGILDAVVK.S,K.IITFTLEK.E,K.SDPVEEAIK.F,R.LVAQGSPPLK.E,\nK.YLSADEALR.L,R.EVHHIEQR.T,K.IIDKPIEPR.R,K.ALQYAFFAEK.S,R.TISKEEILER.C,R.VSDLAGLDVGWK.I,K.GWYQYDKPLGR.I,\nR.CLYSLINEAFR.I,R.VVGVPVALDLITSGK.Y,R.YSPLGDMLCEAGR.F,R.VGLPEVTLGILPGAR.G,R.YSSPTTIATVMSLSK.K,\nK.IGVVVGNCYGFVGNR.M,R.LCNPPVNAVSPTVIR.E,R.KGQGLTGPSLPPGTPVR.K,R.QNPDIPQLEPSDYLR.R,\nK.GGPMFYAASVGLPTVLEK.L,K.TASAQPVSSVGVLGLGTMGR.G\n"," "]
["IPI00324041","Acsl6 Isoform 1 of Long-chain-fatty-acid--CoA ligase 6",79156,6.69,-0.177,1,"Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity); Peroxisome membrane","Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. ",219,2,"K.GEGEICVK.G,K.ALRPTIFPVVPR.L"," "]
["IPI00188989","Acsl1 Long-chain-fatty-acid--CoA ligase 1",79155,6.6,-0.08,1,"Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity); Peroxisome membrane","Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses oleate, arachidonate, eicosapentaenoate and docosahexaenoate as substrates. ",1631,38,"K.ALEDLGR.V,K.IQSSLGGK.V,R.LLMDDLK.V,R.LLMDDLK.V + Oxidation (M),K.GEGEVCVK.G,K.AILEDMVK.L,K.GYLKDPAR.T,\nK.AILEDMVK.L + Oxidation (M),R.WLLDFASK.R,R.MPELIDIR.Q,K.CGVEIIGLK.A,R.MPELIDIR.Q + Oxidation (M),K.LLLEGVENK.L,\nR.TMYDGFQR.G,R.TMYDGFQR.G + Oxidation (M),K.IGFFQGDIR.L,R.IFGQANTSVK.R,K.LAQGEYIAPEK.I,R.IFGQANTSVKR.W,\nK.NAGLKPFEQVK.G,R.GFQGSFEELCR.N,K.VLQPTIFPVVPR.L,R.SQIDELYSTIKI.-,K.AELSVIFADKPEK.A ,R.GIQVSNDGPCLGSR.K ,\nK.LVDVEDMNYQAAK.G ,R.NNSLWDKLIFHK.I ,R.KPNQPYEWISYK.Q ,K.LLLEGVENKLTPCLK.I ,K.QVAEMAECIGSALIQK.G ,\nK.QVAEMAECIGSALIQK.G + Oxidation (M) ,K.IIVIMDSYDNDLVER.G ,K.IIVIMDSYDNDLVER.G + Oxidation (M) ,\nR.LMITGAAPVSATVLTFLR.A ,R.LMITGAAPVSATVLTFLR.A + Oxidation (M) ,R.TAEALDKDGWLHTGDIGK.W ,\nK.LAQGEYIAPEKIENIYLR.S ,K.ALKPPCDLSMQSVEVTGTTEGVR.R + Oxidation (M)\n"," "]
["IPI00339123","Acox3 Peroxisomal acyl-coenzyme A oxidase 3",79080,8.44,-0.179,0,"Peroxisome","Acyl-CoA dehydrogenase activity,fatty acid binding,flavin adenine dinucleotide binding,pristanoyl-CoA oxidase activity",69,4,"R.GGYISGEQTGK.A,R.DSVLWSDIPK.G,K.TVNFLEAYPGILGQK.F,R.EIHALASAGKPLASWTAQR.G\n"," "]
["IPI00476177","Srprb 77 kDa protein",78906,7.14,-0.252,0,"Secreted","Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.",359,17,"K.DSAFGLLR.V,K.VAQEHFGK.G,K.TVLPADGPR.L,R.VSTVLTAQK.D,R.IPSHAVVAR.N,R.DGGGDVAFVK.H,K.GYYAVAVVK.A,\nK.TSYQDCIK.A,K.DLLFRDDTK.C,K.ASDSSINWNNLK.G,K.GTDFQLNQLQGK.K,K.WCAVSEHENTK.C,R.LYLGHSYVTAIR.N,\nK.KGTDFQLNQLQGK.K,R.TAGWNIPMGLLFSR.I,R.NGDGKEDLIWEILK.V,R.SAGWIIPIGLLFCNLPEPR.K\n"," "]
["IPI00205561","Acox2 Peroxisomal acyl-coenzyme A oxidase 2",77548,7.64,-0.243,0,"Peroxisome","Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids.",205,9,"R.TQTLMK.S + Oxidation (M),R.LRPSDPEAK.I,K.LSGLPTLVAR.A,R.SLGSDEQIAK.W,K.ILEYQTQQQK.L,R.EAFLDLLPLIR.K,\nR.FAEVLPDGTYQR.L,R.LTNILDGGLPNTVLR.R,R.SLEDHTPLPGITVGDIGPK.M\n"," "]
["IPI00231200","Por NADPH--cytochrome P450 reductase",77313,5.3,-0.433,1,"Endoplasmic reticulum membrane; Peripheral membrane protein","This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.",424,17,"K.ESSFVEK.M,K.GVATSWLR.A,K.VYTGEMGR.L,K.VYTGEMGR.L + Oxidation (M),R.KLNQGTER.H,R.ALVPMFVR.K + Oxidation (M),K.FAVFGLGNK.T,K.IQTTAPPVK.E,R.YYSIASSSK.V,K.NPFLAAVTANR.K,K.TYEHFNAMGK.Y + Oxidation (M),\nK.DGALTQLNVAFSR.E,K.SYENQKPPFDAK.N,K.YVDQRLEQLGAQR.I,R.TALTYYLDITNPPR.T,R.SDEDYLYREELAR.F,\nR.IFELGLGDDDGNLEEDFITWR.E\n"," "]
["IPI00213231","Acsl5 Long-chain-fatty-acid--CoA ligase 5",77211,7.05,-0.06,1,"Mitochondrion; Endoplasmic reticulum; Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity)","Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL at the villus tip of the crypt-villus axis of the small intestine (By similarity). May have a role in the survival of glioma cells (By similarity). May activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage. It was suggested that it may also stimulate fatty acid oxidation. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids.",370,15,"K.IQSSLGGK.V,K.IENVYSR.S,K.FFQTQIK.S,K.AILEDLQK.V,K.IGFFQGDIR.L,R.VYDKVQNEAK.T,K.LAQGEYIAPEK.I,\nR.LVQGVIFSCGGK.I,R.NSLWDKLVFSK.I,K.NNDLILYYFSDAK.T,K.TVILMDPFDDDLMK.R + Oxidation (M), K.ATMLIENVEKDLTPGLK.T,R.LMITGAAPISTPVLTFFR.A,R.LMITGAAPISTPVLTFFR.A + Oxidation (M),\nK.GAMLTHQNIVSNMAAFLK.F + Oxidation (M)\n"," "]
["IPI00191416","Slc27a5 Bile acyl-CoA synthetase",77129,8.54,0.081,1,"Intracellular membrane-bounded organelle; protein complex; basal plasma membrane (ortholog)","a protein that exhibits cholate-CoA ligase activity; protein complex binding; fatty acid transporter activity (ortholog)",486,18,"K.LAPGK.T,R.LGDTFR.W,K.LYQHVR.S,K.LLAENIR.C,R.FALGNGLR.A,K.ACQAAWALK.A,K.GATAILVLPSK.S,R.WKGENVSTR.E,\nK.LLFYGLNLR.R,R.ADVWENFQQR.F,K.SISALSVFLGLAK.L,R.YLCNVPGQPEDK.K,R.IQDSLEITNTYK.L,K.LGCPVAWINPHSR.G,\nR.YLCNVPGQPEDKK.H,R.SWLPAYATPHFIR.I,K.EATIQEDKGATAILVLPSK.S,R.SLMPDVYQAVCEGTWKL.-\n"," "]
["IPI00207298","Slc26a1 Sulfate anion transporter 1",76482,8.33,0.475,9,"Membrane; Multi-pass membrane protein \n\n","High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate. Mediates sulfate and oxalate transport.\n",59,3,"R.GTEVGVSNR.S,R.RQPPVSQGLLETLK.A,R.SLYSLTGLDAGYSATR.K"," "]
["IPI00367535","RGD1560471 Probable guanine nucleotide exchange factor FLJ41603 homolog",76407,5.86,-0.425,0,"Cytoplasm (inferred)","A protein that exhibits Rho guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN positive regulation of Rho GTPase activity (inferred); ",43,1,"R.LSQLLK.Q"]
["IPI00831745","Anxa6 annexin A6",76108,5.38,-0.432,0,"Cytoplasm; Melanosome","May associate with CD21. May regulate the release of Ca2+ from intracellular stores.\n",378,18,"R.TNAEIR.A,K.SEISGDLAR.L,R.GELSGDFEK.L,K.ALIEILATR.T,K.AMEGAGTDEK.A + Oxidation (M),R.LVFDEYLK.T,\nK.NDTSGEYKK.A,K.CLIEILASR.T,R.SELDMLDIR.E,R.STPEYFAER.L,K.TTGKPIEASIR.G,R.SEIDLLNIRR.E,R.AANDFNPDADAK.A,\nR.TNEQIHQLVAAYK.D,R.SELDMLDIREIFR.T,K.GIGTDEATIIDIITQR.S,K.SLHQAIEGDTSGDFMK.A,K.GFGSDKESILELITSR.S\n"," "]
["IPI00231860","Abcd3 ATP-binding cassette sub-family D member 3",75780,9.32,-0.149,3,"Peroxisome membrane; Multi-pass membrane protein","A protein that exhibits ATP binding; protein self-association; ATPase activity (ortholog); ",270,13,"R.LSQILK.I,R.MSQALGR.I,K.YGLNELK.L,K.GISDQVLK.G,R.TMVSQQDK.G,R.TMVSQQDK.G + Oxidation (M),R.ITELMQVLK.D,\nK.DLNHGKYER.T,R.AVVDKVFLSR.L,K.SGKPPLQNNEK.E,R.DQVIYPDGKEDQK.K,R.IANPDQLLTQDVEK.F,R.YLYEEYLQAFTYYK.M\n"," "]
["IPI00357921","Tmem87b similar to CG17660-PA  ",75289,5.68,0.286,6,"Integral component of membrane (inferred) ","INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine (ortholog); all-trans-retinoic acid (ortholog); benzo[a]pyrene (ortholog).",56,1,"R.LGTVMHR.V + Oxidation (M) "," "]
["IPI00211510","Acox1 Isoform 1 of Peroxisomal acyl-coenzyme A oxidase 1",75030,8.64,-0.284,0,"Peroxisome","Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs.",118,7,"R.LVEIAAK.N,K.VFSDKLPK.I, K.TEVHESYHK.H ,R.ASEAHCHYVVVK.V ,K.EVAWNLTSVDLVR.A ,K.SKEVAWNLTSVDLVR.A ,\nR.YDGNVYENLFEWAK.K \n "," "]
["IPI00358163","Slc25a13 similar to Calcium-binding mitochondrial carrier protein Aralar2",74751,9,0.046,1,"mitochondrial inner membrane (ortholog); mitochondrion (ortholog)","A protein that exhibits calcium ion binding (ortholog); L-aspartate transmembrane transporter activity (ortholog); L-glutamate transmembrane transporter activity (ortholog); ",678,22,"K.YASIEK.N,K.QAFVQR.D,K.VTAIDFR.D,R.VSALSVVR.D,K.RADPAELK.A,K.ILREEGPK.A,R.MTLADIER.I,K.LTVNDFVR.D,\nK.IYSTLAGSR.K,R.DLGFFGIYK.G,R.KIYSTLAGSR.K,R.YEGFFGLYR.G,R.LQVAGEITTGPR.V,R.STGSFVGELMYK.N,\nR.GLLPQLLGVAPEK.A,K.TVELLSGVVDQTK.D,R.YLNIFGESQPNPK.T,R.AGQTTYSGVTDCFR.K,K.FGLYLPLFKPSASTSK.V,\nR.IAPLEEGMLPFNLAEAQR.Q + Oxidation (M),K.ASGDAARPFLLQLAESAYR.F,R.WFYVDFGGVKPVGSELVPK.S\n"," "]
["IPI00767446","Zscan10 zinc finger and SCAN domain containing 10",74629,8.57,0.741,0,"Nucleus","Metal ion binding,nucleic acid binding,sequence-specific DNA binding transcription factor activity",42,1,"R.MPGSEELK.V + Oxidation (M)"," "]
["IPI00392304","Abcg3 74 kDa protein",74574,7.58,0.021,5,"Membrane","ATPase activity",78,2,"R.GGGAK.G,R.SLLLDVLAAR.R"," "]
["IPI00363708","RGD1564709 ATP-binding cassette, sub-family G (WHITE), member 3 family member",74535,7.62,0.123,5,"Membrane","ATP binding,ATPase activity",56,1,"R.SLLLDVLAAR.R"]
["IPI00212220","Pdia4 Protein disulfide-isomerase A4",73017,4.98,-0.539,0,"Endoplasmic reticulum lumen; Melanosome "," A protein that exhibits protein disulfide isomerase activity; poly(A) RNA binding (ortholog)",215,8,"R.TQEEIVAK.V,K.LVLMQPEK.F + Oxidation (M),K.FDVSGYPTIK.I,K.VDATEQTDLAK.R,K.IDATSASMLASK.F, K.KGQAVDYDGSR.T,K.IASTLKDNDPPIAVAK.I,R.EVSQPDWTPPPEVTLTLTK.E\n"," "]
["IPI00870881","Ilvbl ilvB (bacterial acetolactate synthase)-like",72965,8.61,0.204,1,"Membrane (ortholog) ","A protein that exhibits catalytic activity (inferred); magnesium ion binding (inferred); thiamine pyrophosphate binding (inferred); ",70,3,"R.DNEDQVVK.V,R.LGSDVACSLAYTDYHK.A,K.NAQVAQSPVLLLGGAASTLLQK.R\n"," "]
["IPI00200659","Sdha Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",72596,6.75,-0.254,0,"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side ","Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). Can act as a tumor suppressor. ",270,8,"R.AFGGQSLK.F,K.HTLSYVDTK.T,K.NTIIATGGYGR.T,R.VGSVLQEGCEK.V,K.VTLDYRPVIDK.T,R.TGHSLLHTLYGR.S,\nR.LGANSLLDLVVFGR.A,R.AAFGLSEAGFNTACLTK.L\n"," "]
["IPI00206624","Hspa5 78 kDa glucose-regulated protein",72473,5.07,-0.481,0,"Endoplasmic reticulum lumen; Melanosome","Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. ",1892,35,"R.MVNDAEK.F,R.MVNDAEK.F + Oxidation (M),K.FAEEDKK.L,R.NTVVPTKK.S,R.VMEHFIK.L,K.VLEDSDLK.K,R.STMKPVQK.V,\nR.LTPEEIER.M,R.ALSSQHQAR.I,K.VLEDSDLKK.S,K.ITITNDQNR.L,R.VTAEDKGTGNK.N,K.RALSSQHQAR.I,K.VYEGERPLTK.D,\nR.VEIIANDQGNR.I,K.DAGTIAGLNVMR.I + Oxidation (M),K.MKETAEAYLGK.K,K.MKETAEAYLGK.K + Oxidation (M),\nK.NKITITNDQNR.L,K.ELEEIVQPIISK.L,R.TWNDPSVQQDIK.F,R.AKFEELNMDLFR.S,R.AKFEELNMDLFR.S + Oxidation (M),\nK.TFAPEEISAMVLTK.M + Oxidation (M),R.ITPSYVAFTPEGER.L,K.TKPYIQVDIGGGQTK.T,R.IINEPTAAAIAYGLDK.R,\nK.NQLTSNPENTVFDAK.R,R.IDTRNELESYAYSLK.N,R.IINEPTAAAIAYGLDKR.E,K.SQIFSTASDNQPTVTIK.V,\nK.VTHAVVTVPAYFNDAQR.Q,K.DNHLLGTFDLTGIPPAPR.G,K.KSQIFSTASDNQPTVTIK.V ,R.IEIESFFEGEDFSETLTR.A \n"," "]
["IPI00205417","Slc27a2 Very long-chain acyl-CoA synthetase",71447,8.82,-0.17,2,"Endoplasmic reticulum membrane; Multi-pass membrane protein; Peroxisome membrane","Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes.",259,10,"K.IALGNGLR.G,K.AATINHHR.L,K.GEVGLLICK.I,R.ALHDHLGLR.Q,R.LWYGTSLALR.S,R.FFLQLANMAR.Q,K.YDVEKDEPVR.D,\nR.TILHVFLEQAR.K,K.ITELTPFFGYAGGK.T,K.YNATVIQYIGELLR.Y\n"," "]
["IPI00367819","Slc27a6 solute carrier family 27 (fatty acid transporter), member 6",71380,8.54,-0.096,0,"Unknown","Very long-chain fatty acid-CoA ligase activity",42,1,"R.IGDTFR.W"]
["IPI00208205","Hspa8 Heat shock cognate 71 kDa protein",71055,5.37,-0.452,0,"Cytoplasm (By similarity); Melanosome (By similarity); Nucleus; nucleolus (By similarity)","Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. ",116,2,"K.VEIIANDQGNR.T,R.IINEPTAAAIAYGLDK.K"," "]
["IPI00191737","Alb Serum albumin",70682,6.09,-0.38,0,"Secreted","Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. ",146,7,"K.QTALAELVK.H,K.TNCELYEK.L,K.CCSGSLVER.R,R.FPNAEFAEITK.L,K.TVMGDFAQFVDK.C,K.APQVSTPTLVEAAR.N,\nK.DVFLGTFLYEYSR.R\n"," "]
["IPI00196751","Hspa1b;Hspa1a Heat shock 70 kDa protein 1A/1B",70427,5.6,-0.395,0,"Cytoplasm (By similarity)","In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. ",56,1,"K.ITITNDKGR.L"]
["IPI00395267","Pck1 Phosphoenolpyruvate carboxykinase, cytosolic [GTP]",70112,6.09,-0.308,0,"Cytoplasm","Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.",47,1,"K.SGQSQLGR.W"]
["IPI00207355","Hspa2 Heat shock-related 70 kDa protein 2",69884,5.5,-0.486,0,"CatSper complex;cell surface;male germ cell nucleus;mitochondrion;synaptonemal complex","In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.\n",125,4,"R.DRVAAK.N,K.ITITNDKGR.L,K.STAGDTHLGGEDFDNR.M,R.IINEPTAAAIAYGLDKK.G\n"," "]
["IPI00551558 ","Krt2 Keratin, type II cytoskeletal 2 epidermal",69647,7.58,-0.564,0,"Cytoplasm (ortholog); extracellular space (ortholog); extracellular vesicular exosome (ortholog); ","A protein that exhibits structural molecule activity (inferred); ",78,1,"R.GFSSGSAVVSGGSR.R"," "]
["IPI00561262","69 kDa protein",69344,5.53,-0.439,0,"Unknown","Unknown",44,2,"K.DISENKR.A,K.VQVEYKGETK.S"," "]
["IPI00188059","Rpn2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2",69149,5.63,0.09,3,"Endoplasmic reticulum membrane; Multi-pass membrane protein ","Essential subunit of N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. ",208,8,"R.MLAQQAVK.R,K.FELDTSER.K,R.YIANTVELR.V,K.LPSGYYDFSVR.V,K.TGQEVVFVAEPDNK.N,R.VEGDNRYIANTVELR.V,\nK.TGQEVVFVAEPDNKNVYK.F,R.YHVPVVVVPEGSASDTQEQAILR.L\n"," "]
["IPI00395281","Etfdh Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial",69010,7.33,-0.311,0,"Mitochondrion inner membrane","Accepts electrons from ETF and reduces ubiquinone. ",233,10,"R.FAILTEK.H,K.SGSLAAEAIFK.Q,K.GIATNDVGIQK.D,K.QLTSENLQSK.T,K.GSDSEQLKPAK.D,R.ALNEGGLQSIPK.L,\nK.GAPLNTPVTEDR.F,R.NLSIYDGPEQR.F,K.TAGLHVTEYEDNLK.Q,R.FCPAGVYEFVPLEQGDGFR.L\n"," "]
["IPI00454288","Atp5c1 ATP synthase gamma chain",68590,8.03,-0.231,0,"Proton-transporting ATP synthase complex; catalytic core F(1)","Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F1 domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha3beta3. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. ",261,7,"R.ELKPAR.V,K.AEIKGPEDK.K, K.NDMAALTAAGK.E + Oxidation (M),  K.ESTTSEQSAR.M ,K.HLIIGVSSDR.G ,R.VYGTGSLALYEK.A ,K.NASDMIDKLTLTFNR.T + Oxidation (M) \n "," "]
["IPI00204365","Rpn1 Ribophorin1",68473,6.05,-0.226,1,"Endoplasmic reticulum membrane; Single-pass type I membrane protein; Melanosome","Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.\n",274,18,"K.HTGAVLK.G,K.DPAAEAR.M,R.YDYQR.Q,K.SAVEAER.L,K.SLETEHK.A,R.FPLFGGWK.T,K.LPVALDPGSK.I,R.HFDETVNR.Y,\nR.QPDSGISSIR.S,R.DISTLNSGKK.S,R.TVDLSSHLAK.V,K.AVTSEIAVLQSR.L,R.SEDILDYGPFK.D,K.GEDEEDNNLEVR.E,\nK.TILPAAAQDVYYR.D,K.VTAEVVLAHPGGGSTAR.A,R.YDYQRQPDSGISSIR.S,K.VHYENNSPFLTITSMTR.V\n"," "]
["IPI00206948","Retsat All-trans-retinol 13,14-reductase",68001,8.98,-0.049,1,"Endoplasmic reticulum membrane; Peripheral membrane protein ","Retinol saturase carrying out the saturation of the 13- 14 double bond of all-trans-retinol to produce all-trans-13,14- dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A.",287,8,"R.ACGVSVK.K,R.AGGAVLTR.A,R.VLVLEQHTK.A,R.ASTQSLAEVLK.Q,R.GATYGADHDLAR.L,R.ATVQSVLLDSAGR.A,\nK.FLPLPLTQLLNK.F,K.RPPEPLVTDKEAR.K\n"," "]
["IPI00199636","Canx Calnexin",67612,4.48,-0.896,1,"Endoplasmic reticulum membrane; Single-pass type I membrane protein; Melanosome (By similarity)","Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at the synapse.",155,5,"K.TGVYEEK.H,K.SDTSTPPSPK.V,R.GSLSGWILSK.A,K.LPGDKGLVLMSR.A,K.APVPTGEVYFADSFDR.G\n"," "]
["IPI00191385","Sacm1l Phosphatidylinositide phosphatase SAC1",67509,6.83,-0.136,2,"Golgi apparatus;alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex;\nendoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane","Phosphoinositide phosphatase that hydrolyzes PtdIns3P and PtdIns4P. Has low activity towards PtdIns(3,5)P2.",65,3,"R.SLQAQLQR.L,K.YKPDPQINK.V,K.VVTNQEGVFR.S"," "]
["IPI00358005","Chdh Choline dehydrogenase",67088,8.75,-0.387,0,"Mitochondrion inner membrane","Choline dehydrogenase activity,flavin adenine dinucleotide binding",172,11,"R.VLFEGTR.A,R.VIGVENLR.V,R.VLLLEAGPK.D,R.GHAEDYNR.W,R.AEVQTLVSR.V,R.EIFAQEAFAPFR.G,R.AVGVEYIKDGQSHK.A,\nK.MGQPSDPTAVVDQQTR.V,R.KPTQQEAYQVHVGTMR.A,K.GCPALGDENVPVYKPQTLDTQR.-, R.EVILSGGAINSPQLLMLSGVGNADDLKK.L\n"," "]
["IPI00204118","Aifm1 Apoptosis-inducing factor 1, mitochondrial",66966,9.06,-0.231,0,"Mitochondrion intermembrane space;Mitochondrion inner membrane (By similarity);Cytoplasm (By similarity)","Probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis,and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase- independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner. ",112,2,"R.VNAELQAR.S,K.SATEQSGTGIR.S"," "]
["IPI00454476","Kb23 Type II keratin Kb23",64294,7.76,-0.405,0,"Intermediate filament;keratin filament","Structural constituent of cytoskeleton",47,4,"R.FLEQQNK.L,R.LLEGEEQR.L, R.LTAEIENAK.C, R.FAAFIDKVR.F \n "," "]
["IPI00193172","Sgpl1 Sphingosine-1-phosphate lyase 1",64287,9.26,-0.125,1,"Endoplasmic reticulum (ortholog)"," A protein that exhibits sphinganine-1-phosphate aldolase activity (ortholog); ",43,2,"K.IQQQLTK.A,K.ASGAVYSGEPK.L"," "]
["IPI00608161","LOC679149 LOC679149 protein",63170,5.51,-0.126,1,"Unknown","Hydrolase activity",62,2,"K.YWANFAR.H,R.GNWGYLDQVAALR.W"," "]
["IPI00204774","Cesl1 Liver carboxylesterase B-1",62968,6.25,-0.178,0,"Endoplasmic reticulum lumen","Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. ",245,10,"K.FWANFAR.N,R.MNDLLTNRK.E,K.RQPQPHHNEL.-,R.DGASEEEIKLSK.M,K.NFNTVPYIVGINK.Q,R.FAPPQPAEPWSFVK.N,\nR.AISESGVVLITELFTK.D,R.LGIWGFFSTGDEHSR.G,R.LKAEEVAFWTQLLAK.R,K.FASIYGIPEDIIPVAIEK.Y\n"," "]
["IPI00679256","Es22;LOC100125372 Liver carboxylesterase 4",62668,6.29,-0.164,0,"Endoplasmic reticulum lumen","Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes omicron- nitrophenyl acetate and alpha-naphthyl acetate. It also hydrolyzes acetanilide and, distinctively, palmitoyl-CoA. ",313,13,"K.GSDDSIK.I,K.FWANFAR.N,K.MAITLLEK.F,R.MNDLLTNRK.E,K.RQPQPHHNEL.-,R.DGASEEEIKLSK.M,K.NFNTVPYIVGINK.Q,\nR.FAPPQPAEPWSFVK.N,R.AISESGVVFLPGLLTK.D,R.LGIWGFFSTGDEHSR.G,R.LKAEEVAFWTQLLAK.R,K.FASLYGIPEDIIPVAIEK.Y,\nK.HVVGDHADDLYSVFGAPILR.D\n"," "]
["IPI00326972","Ces3 Carboxylesterase 3",62393,6.1,-0.105,0,"Endoplasmic reticulum lumen; Cytoplasm, cytosol (By similarity); Lipid droplet ","Major lipase in white adipose tissue (By similarity). Involved in the metabolism of xenobiotics and of natural substrates. Hydrolyzes triacylglycerols and monoacylglycerols, with a preference for monoacylglycerols. The susceptibility of the substrate increases with decreasing acyl chain length of the fatty acid moiety. Catalyzes the synthesis of fatty acid ethyl esters. ",290,9,"K.LDLLGNPK.E,K.YWANFAR.N,K.IGASTQAAQR.L,K.TPEEILAEK.S,K.YFGGTDDPAK.R,K.DGASEEETNLSK.M,K.SFNTVPYIVGINK.Q,R.FAPPQPAEPWNFVK.N,K.ESYPFLPTVIDGVVLPK.T\n"," "]
["IPI00475676","LOC641316 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial",62286,8.41,-0.177,0,"Intermediate filament (inferred); mitochondrial matrix (inferred); mitochondrion (inferred)","A protein that exhibits 1-pyrroline-5-carboxylate dehydrogenase activity (inferred); identical protein binding (inferred); oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor (inferred); ",53,2,"K.TIVQEATR.M,R.LYVPQSLWPQIK.G"," "]
["IPI00202513","Ces6 Carboxylesterase isoenzyme",62162,6.19,-0.103,0,"Intracellular membrane-bounded organelle","Carboxylic ester hydrolase activity",90,5,"R.ETLPTVLK.S,K.YWANFAR.T,R.GNWGYLDQVAALR.W,R.LGVLGFFSTGDQNAR.G,R.FAPPEDPEPWSGVR.D\n"," "]
["IPI00205749","Es22 Liver carboxylesterase 3",61961,5.71,-0.09,0,"Endoplasmic reticulum lumen","A protein that exhibits palmitoyl-CoA hydrolase activity; ",72,3,"K.LNLFSLDLHGDSR.Q,R.QSYPFVPTVLDGVVLPK.M,K.SSFLLNLPEEAIPVAVEK.Y"," "]
["IPI00324633","Glud1 Glutamate dehydrogenase 1, mitochondrial",61719,8.05,-0.306,0,"Mitochondrion matrix","May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. ",193,7,"K.NLNHVSYGR.L,R.TAAYVNAIEK.V,K.NYTDNELEK.I,R.YSTDVSVDEVK.A,R.DDGSWEVIEGYR.A,K.HGGTIPVVPTAEFQDR.I,\nR.DSNYHLLMSVQESLER.K\n"," "]
["IPI00203473","Ugt2b36 UDP-glucuronosyltransferase 2B4",61590,7.62,-0.025,1,"Microsome membrane; Single-pass membrane protein (Potential); Endoplasmic reticulum membrane","UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Catalyzes the transfer of glucuronic acid from UDP-glucuronic acid to various aglycone molecules. Catalyzes the glucuronidation of monoterpenoid alcohols, such as (-)- borneol, (+)-menthol, and (-)- nopol. In addition, a number of simple phenolic compounds, such as hydroxybiphenyls, 7- hydroxylated coumarins, p-nitrophenol, and food-derived substances (e.g. naringenin and eugenol), and 4-methylumbelliferone are also substrates.",94,6,"K.AEMWLIR.S,K.WLPQNDLLGHPK.T,R.FVNVWTYELPR.D,K.TLGRPTTLAEIMGK.A,K.ANIIAWALAQIPQK.V,\nK.SDLLNALEEVIDNPFYK.K \n"," "]
["IPI00554004","Ugt2b34 similar to UDP glucuronosyltransferase 2 family, polypeptide B34     ",61568,6.97,-0.028,1,"Mitochondrial inner membrane (ortholog)","A protein that exhibits transferase activity, transferring hexosyl groups (inferred); ",131,7,"R.MTFVER.M,K.ADIWLIR.T,R.VILDELLK.K,K.IPLVYSLR.F,K.WIPQNDLLGHPK.T,R.FEGKKPETLGSNTR.L, R.LDFLTMSSTDLFTALK.T\n"," "]
["IPI00471524","Ugt2b36 UDP glucuronosyltransferase 2 family, polypeptide B36",61557,8.18,-0.042,1,"Membrane","Transferase activity, transferring hexosyl groups",115,7,"K.AEMWLIR.S,R.FSPGYTIEK.Y, K.KPPTLGPNTR.L ,K.WLPQNDLLGHPK.T,R.FVNVWTYELPR.D, K.TLGRPTTLAEIMGK.A ,\nK.FVTFPTSFSSHDLENFFTR.F \n"," "]
["IPI00212110","Ugt2b UDP-glucuronosyltransferase 2B2",61459,8.7,0.008,1,"Microsome membrane; Single-pass membrane protein (Potential); Endoplasmic reticulum membrane","UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 2B2 acts on various endogenous steroids, especially etiocholanolone and androsterone. ",433,8,"K.VEIWLIR.S,K.TPATLGPNTR.V, K.IILDELVQR.G ,K.LLDVWTYELPR.D ,K.WLPQNDLLGHPK.T ,K.FDGKTPATLGPNTR.V ,\nK.ANAIAWALAQIPQK.V ,K.FILPPSYVPVILSGLAGK.M \n "," "]
["IPI00554206","Ugt2b UDP glycosyltransferase 2 family, polypeptide B",61416,8.6,0.026,1,"Membrane","Transferase activity, transferring hexosyl groups",433,8,"K.VEIWLIR.S,K.TPATLGPNTR.V,K.IILDELVQR.G,K.LLDVWTYELPR.D,K.WLPQNDILGHPK.T,K.FDGKTPATLGPNTR.V,\nK.ANAIAWALAQIPQK.V,K.FILPPSYVPVILSGLAGK.M\n\n "," "]
["IPI00207299","Aspg 60 kDa lysophospholipase",61269,5.46,0.005,0,"Unknown","Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities. ",46,1,"K.LLAKDLR.G"]
["IPI00190402","Ugt2b17 UDP-glucuronosyltransferase 2B1",61072,8.67,-0.002,1,"Microsome membrane; Single-pass membrane protein; Endoplasmic reticulum membrane","UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.",130,5,"K.WIPQNDLLGHPK.T,R.FDGKKPDTLGSNTR.L, R.VDFSILSTTGLLTALK.I ,K.FSGGLPLPPSYVPVVLSELSDR.M, \nK.SWSQFYSDVLGRPTTLTEMMGK.A \n"," "]
["IPI00195423","Ugt2b37 UDP-glucuronosyltransferase 2B5",61066,8.85,-0.032,1,"Microsome membrane; Single-pass membrane protein (Potential); Endoplasmic reticulum membrane","UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 2B37 is about 30-fold less active than 2B5 toward testosterone and dihydrotestosterone.",164,9,"K.SDLFNALK.E,K.GAAVTLNIR.T, K.AEMWLIR.S,K.IPATLGPNTR.V,K.TILDELVQR.G,K.AIFWIEYVMR.H, K.WLPQNDLLGHPK.T,\nK.ANAIAWALAQIPQK.V,K.NWDPFYTEILGRPTTLAETMGK.A\n"," "]
["IPI00327626","Ugt2b5 UDP-glucuronosyltransferase 2B3",61055,8.47,-0.046,1,"Microsome membrane; Single-pass membrane protein (Potential); Endoplasmic reticulum membrane","UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 2B17 is active on testosterone. ",368,12,"K.GAAVTLNIR.T,K.AEMWLIR.S, K.TPATLGPNTR.V,K.TPATLGPNTR.V,K.TILDELVQR.G ,K.WLPQNDLLGHPK.T,\nK.LVDVWTYELQR.D ,K.FDGKTPATLGPNTR.V,K.ANAIAWALAQIPQK.V,K.VLVWPMEFSHWMNIK.T ,R.GHEVTVLKPSAYYVLDPK.K ,R.DTCLSYSPLLQNMIDGFSDYYLSLCK.D + Oxidation (M) \n "," "]
["IPI00831724","Cyp4v3 Cytochrome P450 4V3",60997,8.57,-0.246,1,"Endoplasmic reticulum membrane;Single-pass membrane protein","Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12).",111,4,"R.VFPSVPLFAR.S,K.LWIGPVPLVALYK.A,K.NIGAQSNGDSEYVR.T,K.FLQPWLGLGLLTSTGSK.W\n"," "]
["IPI00565768","RGD1559459 similar to UDP glucuronosyltransferase 2 family, polypeptide B34  wu",60841,8.18,0.016,2,"Membrane","Unknown",103,7,"R.MTFVER.V,K.ADIWLIR.T,K.IPLVYSLR.F,K.WIPQNDLLGHPK.T,K.QSFWGYFLMLQK.L,R.FEGKKPETLGSNTR.L,\nR.LDFLTMSSTDLLTALR.T\n"," "]
["IPI00475707","Ugt1a6;Ugt1a1 UDP glycosyltransferase 1 family, polypeptide A6",60823,8.91,-0.041,1,"Microsome; Endoplasmic reticulum membrane;Single-pass membrane protein (Potential) ","UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.",110,6,"K.NTILVK.W,K.DSATLSFLR.E,R.IPQTVLWR.Y, R.YTGTRPSNLAK.N, K.WLPQNDLLGHPK.A,R.GAGVTLNVLEMTADDLENALK.T\n "," "]
["IPI00476793","Ugt1a8;Ugt1a1 UDP glycosyltransferase 1 family, polypeptide A8",60751,8.6,0.005,1,"Membrane","Transferase activity, transferring hexosyl groups",106,5,"K.NTILVK.W,R.IPQTVLWR.Y,R.YTGTRPSNLAK.N,K.WLPQNDLLGHPK.A,R.GAGVTLNVLEMTADDLENALK.T\n"," "]
["IPI00206330","Cyp4f4 Cytochrome P450 4F4",60638,6.97,-0.147,2," Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane","Aromatase activity,heme binding,iron ion binding",41,1,"R.SPLAFIPFSAGPR.N"]
["IPI00208281","LOC286989 UDP-glucuronosyltransferase 2B8",60620,8.51,0.011,1,"Microsome membrane; Single-pass membrane protein (Potential);Endoplasmic reticulum membrane","UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Plays a role in steroid metabolism and is active with Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro).",110,3,"K.ELIAK.L,K.IILDELVQR.G, K.WIPQNDLLGHPK.T"," "]
["IPI00565267","Fmo3 Dimethylaniline monooxygenase [N-oxide-forming] 3",60606,8.44,-0.125,0,"Microsome membrane (By similarity); Endoplasmic reticulum membrane (By similarity) ","Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Acts on TMA to produce TMA-N-oxide. Has activities of methimazole S-oxidation and NADPH oxidation associated with the N- or S- oxidation of trimethylamine and thioacetamide.",143,8,"K.DSFPGLNR.F,R.SDDVGGLWK.F,K.FSDHTEEGR.A,R.NAILTQWDR.S,K.YIQFETLVTR.I,K.EPVFNDELPAR.I,R.ASIYQSVFTNSSK.E,\nK.NNLPTAISDWWYMK.Q + Oxidation (M)\n"," "]
["IPI00203106","Fmo5 Dimethylaniline monooxygenase [N-oxide-forming] 5",60530,9.01,-0.211,1,"Microsome membrane;Endoplasmic reticulum membrane","In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme. ",138,8,"R.GAWILNR.V,R.ITNYLSK.I,K.QVFLSTR.R,K.SVIINTSK.E,R.WATQVFK.G,K.TILTTEDR.I,R.SDDIGGLWR.Y,\nR.IAVIGSGASGLTCIK.C\n"," "]
["IPI00195148","Es1 Liver carboxylesterase 1",60479,5.51,-0.106,0,"Endoplasmic reticulum lumen. Note=Microsomal membrane, lumen of endoplasmic reticulum. ","Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant. ",54,2,"K.FWANFAR.N,R.FAPPEPAEPWSFVK.N"," "]
["IPI00201564","Fmo1 Dimethylaniline monooxygenase [N-oxide-forming] 1",60471,8.57,-0.009,1,"Microsome membrane; Endoplasmic reticulum membrane.","This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.",66,3,"K.VCSITK.R,R.FTEHVEEGR.A,K.VEDGQASLYK.Y"," "]
["IPI00742454","Ugt1a5 UDP glycosyltransferase 1 family, polypeptide A5 precursor ",60453,8.9,0.069,1,"Membrane","Catalytical activity",66,5,"R.IPQTVLWR.Y,K.AMEIAEALGR.I,R.YTGTRPSNLAK.N,K.YLGIPTVFFLR.Y,K.WLPQNDLLGHPK.A\n"," "]
["IPI00213569","Ugt1a1 UDP-glucuronosyltransferase 1-1",60422,8.77,0.077,2,"Microsome; Endoplasmic reticulum membrane; Single-pass membrane protein (Potential)","UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Glucuronates opioids and bilirubin. ",726,21,"K.NTILVK.W,R.MNFLQR.V,K.SCAYGCR.K,K.SLSSNTDR.M,K.EGSFYTMR.K + Oxidation (M),R.IPQTVLWR.Y,\nK.SYKENIMR.L + Oxidation (M),K.AMEIAEALGR.I,K.AMEIAEALGR.I + Oxidation (M),R.YTGTRPSNLAK.N,R.SVFDQDPFLLR.V,\nK.DLLSPASIWLMR.N,K.DLLSPASIWLMR.N + Oxidation (M),K.WLPQNDLLGHPK.A,K.DLLSPASIWLMR.N + Oxidation (M),\nK.WLPQNDLLGHPK.A,R.VVYSPYGSLATEILQK.E,R.VKNMIIALTENFLCR.V,K.EVTVKDLLSPASIWLMR.N,\nR.GAGVTLNVLEMTADDLENALK.T,R.GAGVTLNVLEMTADDLENALK.T + Oxidation (M)\n"," "]
["IPI00780674","Ugt1a7c UDP-glucuronosyltransferase 1-7",60216,8.6,0.001,1,"Microsome; Endoplasmic reticulum membrane; Single-pass membrane protein","UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.\n",200,10,"K.NTILVK.W,K.SCAYGCR.K,K.SYKENIMR.L + Oxidation (M),K.AMEIAEALGR.I,K.AMEIAEALGR.I + Oxidation (M),\nR.YTGTRPSNLAK.N,K.WLPQNDLLGHPK.A,K.TYSVSHTQEDLNR.E,R.GAGVTLNVLEMTADDLENALK.T,\nR.GAGVTLNVLEMTADDLENALK.T + Oxidation (M)\n"," "]
["IPI00214436","Ugt1a1;Ugt1a7c UGT1A7",60111,8.98,0.035,1," Single-pass membrane protein","Transferase activity, transferring hexosyl groups\n",127,8,"K.NTILVK.W,K.SCAYGCR.K,R.IPQTVLWR.Y,K.AMEIAEALGR.I,K.AMEIAEALGR.I + Oxidation (M),R.YTGTRPSNLAK.N,\nK.WLPQNDLLGHPK.A,K.TYSVSHTQEDLNR.E\n"," "]
["IPI00231742","Cat Catalase",60062,7.07,-0.639,0,"Peroxisome. ","Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells. ",551,28,"R.VANYQR.D,K.RTPIAVR.F,K.VFEHIGK.R,K.VLNEEER.K,K.NLPVEEAGR.L,K.VFEHIGKR.T,K.DAQLFIQR.K,K.DYPLIPVGK.L,\nR.LFAYPDTHR.H,R.LCENIANHLK.D,R.LAQEDPDYGLR.D,K.LVNANGEAVYCK.F,K.NFTDVHPDYGAR.V,R.FSTVAGESGSADTVR.D,\nR.FNSANEDNVTQVR.T,R.DAMLFPSFIHSQK.R,R.DAMLFPSFIHSQK.R + Oxidation (M),R.VQALLDQYNSQKPK.N,\nK.VWPHKDYPLIPVGK.L,K.RFNSANEDNVTQVR.T,K.EAETFPFNPFDLTK.V,K.NAIHTYVQAGSHIAAK.G,K.GAGAFGYFEVTHDITR.Y,\nR.LGPNYLQIPVNCPYR.A,R.FSTVAGESGSADTVRDPR.G,R.APQKPDVLTTGGGNPIGDK.L,R.LCENIANHLKDAQLFIQR.K,\nR.APQKPDVLTTGGGNPIGDKLNIMTAGPR.G + Oxidation (M)\n"," "]
["IPI00396910","Atp5a1 ATP synthase subunit alpha, mitochondrial",59831,9.22,-0.09,0,"Mitochondrion inner membrane (By similarity); Cell membrane; Peripheral membrane protein; Extracellular side (By similarity)","Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites. ",943,31,"R.LTELLK.Q,K.APGIIPR.I, K.QVAGTMK.L ,R.VGSAAQTR.A, R.ELIIGDR.Q, R.STVAQLVK.R ,R.QMSLLLR.R, R.LTDADAMK.Y, \nK.ISEQSDAK.L ,R.LTDADAMK.Y + Oxidation (M) ,K.LELAQYR.E ,R.FNDGTDEK.K ,R.VLSIGDGIAR.V ,R.STVAQLVKR.L ,\nK.RLTDADAMK.Y ,K.AVDSLVPIGR.G ,R.FNDGTDEKK.K ,R.VGLKAPGIIPR.I ,R.VVDALGNAIDGK.G ,R.SDGKISEQSDAK.L ,\nK.HALIIYDDLSK.Q ,K.TSIAIDTIINQK.R ,R.ISVREPMQTGIK.A ,K.GIRPAINVGLSVSR.V, R.EAYPGDVFYLHSR.L, \nR.ILGADTSVDLEETGR.V ,K.LKEIVTNFLAGFEP.-, R.TGAIVDVPVGDELLGR.V ,R.VVDALGNAIDGKGPVGSK.I , K.QGQYSPMAIEEQVAVIYAGVR.G ,R.EVAAFAQFGSDLDAATQQLLSR.G \n "," "]
["IPI00765011","LOC295810 similar to Actin, cytoplasmic 2",59163,5.67,-0.162,0,"Cytoplasm › cytoskeleton\n","Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.\n",858,20,"K.IIAPPER.K,K.RGILTLK.Y,K.CDVDIRK.D,K.AGFAGDDAPR.A,R.DLTDYLMK.I,R.DLTDYLMK.I + Oxidation (M), R.GYSFTTTAER.E,K.EITALAPSTMK.I,R.HQGVMVGMGQK.D,K.EITALAPSTMK.I + Oxidation (M),R.HQGVMVGMGQK.D + Oxidation (M),K.DSYVGDEAQSK.R,R.AVFPSIVGRPR.H,R.HQGVMVGMGQK.D + 2 Oxidation (M),K.DSYVGDEAQSKR.G,\nK.IWHHTFYNELR.V,K.QEYDESGPSIVHR.K,R.LDLAGRDLTDYLMK.I,K.SYELPDGQVITIGNER.F\n"," "]
["IPI00231774","Maob Amine oxidase [flavin-containing] B",59049,8.46,-0.166,1,"Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side","Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. ",132,10,"R.NQLITR.V,R.VPLGSVIK.C,R.IKDILGDR.V,K.ELGLETYK.V,R.IISTTNGGQER.K,K.TLNHEIYEAK.Y,R.KFIGGSGQVSER.I,\nK.YVDLGGSYVGPTQNR.I,K.ELGLETYKVNEVER.L,K.VLNSQEALQPVHYEEK.N\n"," "]
["IPI00781400","Cyp2c6 58 kDa protein",58706,7.21,-0.154,0,"Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane","Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. ",547,23,"R.QSSGR.G,R.VQEEAR.C,R.NLGMGKR.N,K.NVYHIR.N,K.CPEVTAK.V,R.GSFPVAEK.I,R.FTLTTLR.N,K.VQEEIDR.V,R.SPCMQDR.S,\nR.YALLLLLK.C,R.MCAGEGLAR.M,R.MCAGEGLAR.M + Oxidation (M),K.NITQSLTSFSK.V,K.VQEEIDRVVGK.H,R.NIEDRVQEEAR.C,\nK.EHQESLDVTNPR.D,K.EALIDHGEEFAER.G,K.INKDLGIVFSHGNR.W,R.MPYTDAMIHEVQR.F,K.IKEHQESLDVTNPR.D,\nR.FDYKDQDFLNLMEK.L,R.FIDLIPTNLPHAVTCDIK.F,K.LPPGPIPLPIIGNIFQLNVK.N\n"," "]
["IPI00203318","Cyp4a3 Cytochrome P450 4A14",58537,9.17,-0.238,2,"Endoplasmic reticulum membrane; Peripheral membrane protein;Microsome membrane","Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.",111,7,"K.VFDPSR.F,R.LYPPVPSVSR.E,R.VLLYDPDYVK.V,R.ELSSPVTFPDGR.S,K.AQLQNEEELQK.A,R.KAQLQNEEELQK.A,\nK.DREFQQVLTWVEK.F\n"," "]
["IPI00203317","Cyp4a2 Cytochrome P450 4A2",58274,9.18,-0.253,1,"Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane","Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.",111,6,"K.VFDPSR.F,R.VLLYDPDYVK.V, R.ELSSPVTFPDGR.S,K.AQLQNEEELQK.A,R.KAQLQNEEELQK.A,K.DREFQQVLTWVEK.F \n"," "]
["IPI00210116","Lman1 Protein ERGIC-53",58194,6.1,-0.544,1,"Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein By similarity. Golgi apparatus membrane","Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. ",68,8,"K.DISEKEK.E,R.TQQEILR.Q,R.DIDSLAQR.S,K.NSMSETLR.L,R.QVFEGQNR.I,R.SMSSNEKPK.C,R.YVSSLTEEISR.R,\nK.GHPDLQGQPADDIFESIGDRELR.Q\n"," "]
["IPI00192118","Cyp2c79 similar to cytochrome P450, family 2, subfamily c, polypeptide 66  ",58085,7.53,-0.096,1,"Membrane","Caffeine oxidase activity (ortholog); monooxygenase activity (ortholog); ",45,2,"R.VQEEAR.C,R.SPCMQDR.H"," "]
["IPI00196764","Cyp3a2 Cytochrome P450 3A2",58036,8.88,-0.084,3,"Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane","Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. ",90,4,"R.ALLSPTFTSGR.L,K.DIELDGLFIPK.G, K.YLKQEAETGKPVTMK.K, K.GSIDPYVYLPFGNGPR.N\n "," "]
["IPI00780253","Protein ",57861,6.32,-0.08,0,"Unknown","Unknown",240,16,"R.QSSGR.G,R.VQEEAR.C,R.NLGMGKR.N,K.NVYHIR.N,R.GSFPVAEK.I,R.FTLTTLR.N,K.VQEEIDR.V,R.SPCMQDR.S,R.YALLLLLK.Y,\nK.NITQSLTSFSK.V,R.NIEDRVQEEAR.C,K.EALIDHGEEFAER.G,R.MPYTDAMIHEVQR.F,R.FDYKDQDFLNLMEK.L,\nR.FIDLIPTNLPHAVTCDIK.F,K.LPPGPIPLPIIGNIFQLNVK.N\n"," "]
["IPI00766868","Cyp2b2 similar to Cytochrome P450 2B2  ",57767,6.51,-0.126,1,"Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane","Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.\n",200,9,"R.FDYTDR.Q,R.ATLDPSAPR.D,R.DFIDTYLLR.M,R.GGLLNSFMQFR.E,R.FADLAPIGLPHR.V,K.EALVGQAEDFSGR.G,\nK.MPYTDAVIHEIQR.F,K.EIDQVIGSHRPPSLDDR.T,R.GNFPPGPRPLPLLGNLLQLDR.G\n"," "]
["IPI00327781","Cyp2c Cytochrome P450 2C11",57658,7.59,-0.159,0,"Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane","Metabolizes testosterone mainly in positions 2 alpha and 16 alpha. ",108,16,"K.HVDVTAK.V,R.FNENFR.L，R.GSFPVSER.V，K.DIGQSIKK.F，R.SPCMKDR.S，K.VQEEIER.V，R.YGLLLLLK.H，R.ICAGEALAR.T，R.DFIDCFLNK.M，K.EALVDLGEEFSGR.G，R.YIDLVPTNLPHLVTR.D，R.SQMPYTDAVVHEIQR.Y，\nR.FDYKDPTFLNLMHR.F，K.LPPGPTPLPIIGNTLQIYMK.D，R.GKLPPGPTPLPIIGNTLQIYMK.D，\nK.GAPFDPTFILGCAPCNVICSIIFQNR.F \n "," "]
["IPI00231473","Cyp2d2 Cytochrome P450 2D26",57620,6.96,-0.029,1,"Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane","Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. ",60,3,"R.FSVSTLR.D,R.ACLGEPLAR.M,K.AVSNVIASLVYAR.R"," "]
["IPI00324443","Cyp2d1 Cytochrome P450 2D1",57595,6.87,-0.03,2,"Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane","Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.",150,8,"K.VFQGQK.T,R.FSVSTLR.T，R.ACLGEPLAR.M，R.FGDIAPLNLPR.F，R.NLTDAFLAEVEK.A ，R.IPGLADKVFQGQK.T， \nK.ALCNVIASLIFAR.R ，K.TFMALLDNLLAENR.T\n "," "]
["IPI00213641","Cyp3a18 Cytochrome P450 3A18",57555,9.06,-0.173,2,"Endoplasmic reticulum membrane; Peripheral membrane protein;Microsome membrane","Catalyzes 16-beta- and 6-alpha-hydroxylations of testosterone.\n",48,2,"K.LQNEIDR.A,K.GSIDPYVYLPFGNGPR.N"," "]
["IPI00324741","Pdia3 Protein disulfide-isomerase A3",57499,5.88,-0.455,0,"Endoplasmic reticulum lumen;Melanosome "," A protein that exhibits poly(A) RNA binding (ortholog); ",592,24,"K.YKELGEK.L,K.DPNIVIAK.M，K.LNFAVASR.K，K.TFLDAGHK.L，R.LKGIVPLAK.V，K.YGVSGYPTLK.I，R.TADGIVSHLKK.Q，\nK.FVMQEEFSR.D，R.LAPEYEAAATR.L，K.LSKDPNIVIAK.M，R.DGEEAGAYDGPR.T，R.FAHTNVESLVK.E，K.GFPTIYFSPANK.K，\nR.FLQEYFDGNLK.R，R.DLFSDGHSEFLK.A，K.SEPIPETNEGPVK.V，K.VDCTANTNTCNK.Y，R.ELNDFISYLQR.E，\nK.GFPTIYFSPANKK.L，R.FLQEYFDGNLKR.Y，R.EATNPPIIQEEKPK.K，K.DLLTAYYDVDYEK.N，K.MDATANDVPSPYEVK.G，\nK.IFRDGEEAGAYDGPR.T\n"," "]
["IPI00210444","Hmgcs2 Hydroxymethylglutaryl-CoA synthase, mitochondrial",57332,8.86,-0.36,0,"Mitochondrion","This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.",58,1,"K.LVSSVSDLPK.R "]
["IPI00200792","Krt85 Type II keratin Kb25",57325,6.34,-0.392,0,"Extracellular space (ortholog)","A protein that exhibits structural molecule activity (inferred); ",44,4,"R.FLEQQNK.L,R.LTAEIENAK.C，K.AQYDDVASR.S，K.FAAFIDKVR.F\n"," "]
["IPI00198887","P4hb Protein disulfide-isomerase",57315,4.82,-0.382,0,"Endoplasmic reticulum lumen (By similarity); Melanosome (By similarity); Cell membrane; Peripheral membrane protein (Potential)","This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.",638,25,"K.LSNFKK.A,K.LLDFIK.H，K.KFDEGR.N，K.IFGGEIK.T，K.EECPAVR.L，K.ALAPEYAK.A，K.SVSDYDGK.L，R.ILEFFGLK.K，\nK.QLAPIWDK.L，K.LKAEGSEIR.L，R.NNFEGEITK.E，R.TVIDYNGER.T，K.THILLFLPK.S，R.ILEFFGLKK.E，R.EADDIVNWLK.K，\nR.LITLEEEMTK.Y，K.MDSTANEVEAVK.V，R.NNFEGEITKEK.L，K.NFEEVAFDEKK.N，K.YKPESDELTAEK.I，K.YQLDKDGVVLFK.K，K.ITQFCHHFLEGK.I，K.VDATEESDLAQQYGVR.G，K.ILFIFIDSDHTDNQR.I，K.HNQLPLVIEFTEQTAPK.I\n"," "]
["IPI00198484","Ces5 57 kDa protein   ",57274,6,-0.187,0,"Extracellular region (inferred) ","A protein that exhibits hydrolase activity (inferred); ",62,2,"K.YWANFAR.H,R.GNWGYLDQVAALR.W"," "]
["IPI00763231","Cyp2b1 Cytochrome P450 2B1",57212,7,-0.1,1,"Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane","Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.\n",76,3,"R.ATLDPSAPR.D ,R.DFIDTYLLR.M ,K.MPYTDAVIHEIQR.F"," "]
["IPI00363783","Cyp2w1 similar to cytochrome P450, family 2, subfamily W, polypeptide 1",57197,8.76,0.077,2,"Membrane","A protein that exhibits heme binding (inferred); iron ion binding (inferred); monooxygenase activity (inferred); INVOLVED IN oxidation-reduction process (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine (ortholog); all-trans-retinoic acid (ortholog); benzo[a]pyrene (ortholog)",49,1,"R.VQEELDR.V"]
["IPI00198325","Cyp2d4v1 Cytochrome P450 2D4",57174,6.87,-0.03,1,"Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane","Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. ",51,1,"R.ACLGEPLAR.M"]
["IPI00192326","Cyp2g1 Cytochrome P450 2G1",57143,8.84,-0.121,1,"Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane","Cytochromes P450 are a group of heme-thiolate monooxygenases. This isozyme seems to be implicated in olfaction.\n",56,1,"K.MPYTDAVIHEIQR.L"," "]
["IPI00327991","Cyp2c23 Cytochrome P450 2C23",57024,8.68,-0.143,1,"Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane","Predominant enzyme isoform responsible for arachidonic acid epoxidation in the rat kidney. Catalyzes the NADPH-dependent metabolism of arachidonic acid to a mixture of 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids (EETS) as the only oxygenation products. Low rate of lauric acid hydroxylation at the (omega-1)- position. ",44,1,"R.VQEEAR.C"]
["IPI00324912","Cyp2e1 Cytochrome P450 2E1",56990,8.6,-0.139,1,"Endoplasmic reticulum membrane; Peripheral membrane protein;Microsome membrane","Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. ",135,13,"K.AFSAGKR.V,R.FSLSILR.D，K.YPEIEEK.L，K.LHEEIDR.V，R.YGLLILMK.Y，R.VCVGEGLAR.M，R.GDIPVFQEYK.N，\nK.GIIFNNGPTWK.D，R.DTVFQGYVIPK.G，K.EVLLNHKNEFSGR.G，K.AKEHLQSLDINCAR.D，R.FINLVPSNLPHEATR.D，\nK.GTVVIPTLDSLLYDSHEFPDPEK.F\n"," "]
["IPI00198324","Cyp2b3 Cytochrome P450 2B3",56861,6.39,-0.04,1,"Endoplasmic reticulum membrane; Peripheral membrane protein;Microsome membrane","Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.",95,7,"R.VPTLDDR.S ,R.LFVATMR.D， K.SFIQLQEK.H ，K.EIDQVIGSQR.V ，R.FSDVSPMGLPCR.I， R.EALVDHAEAFSGR.G ，\nK.QSVEDQIKEEAK.C \n"," "]
["IPI00371670","LOC293989 Cytochrome P450-like",56789,7.17,-0.128,0,"Endoplasmic reticulum membrane (inferred) ","Heme binding,iron ion binding,monooxygenase activity,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen.",534,20,"R.QSSGR.G,R.NLGMGKR.N,K.CPEVTAK.V,R.FTLTTLR.N,K.VQEEIDR.V,R.SPCMQDR.S,R.YALLLLLK.C,R.MCAGEGLAR.M,\nR.MCAGEGLAR.M + Oxidation (M),R.DFIDYYLIK.W,K.NITQSLTSFSK.V,K.VQEEIDRVVGK.H,K.EHQESLDVTNPR.D,\nK.EALIDHGEEFAER.G,K.INKDLGIVFSHGNR.W,R.MPYTDAMIHEVQR.F,K.IKEHQESLDVTNPR.D,R.FDYKDQDFLNLMEK.L,\nR.FIDLIPTNLPHAVTCDIK.F,K.LPPGPIPLPIIGNIFQLNVK.N\n"," "]
["IPI00196748","Cyp2c7 Cytochrome P450 2C7",56778,8.69,-0.264,0,"Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane","Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.",131,2,"K.VQEEIDR.V,R.SPCMQDR.K"," "]
["IPI00390958","Cyp2c6 Cytochrome P450 2C6",56708,7.21,-0.154,0,"Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane","Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.",544,23,"R.QSSGR.G,R.VQEEAR.C,R.NLGMGKR.N,K.NVYHIR.N,K.CPEVTAK.V,R.GSFPVAEK.I,R.FTLTTLR.N,K.VQEEIDR.V,R.SPCMQDR.S,\nR.YALLLLLK.C,R.MCAGEGLAR.M,R.MCAGEGLAR.M + Oxidation (M),R.DFIDYYLIK.W ,K.NITQSLTSFSK.V,K.VQEEIDRVVGK.H,\nR.NIEDRVQEEAR.C,K.EHQESLDVTNPR.D,K.EALIDHGEEFAER.G,K.INKDLGIVFSHGNR.W,K.IKEHQESLDVTNPR.D,\nR.FDYKDQDFLNLMEK.L,R.FIDLIPTNLPHAVTCDIK.F,K.LPPGPIPLPIIGNIFQLNVK.N\n"," "]
["IPI00200856","Cyp2b21 Cytochrome P450 CYP2B21",56696,6.73,-0.066,1,"Membrane","Heme binding,iron ion binding,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen,oxygen binding",64,2,"R.DFIDTYLLR.M,K.MPYTDAVIHEIQR.F"," "]
["IPI00203312","Cyp2a3a Cytochrome P450 2A3",56645,9.19,-0.203,1,"Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane","Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.",107,2,"R.YGPVFTIHLGPR.R,K.EALVDQAEEFSGR.G"," "]
["IPI00203090","Fmo4 Flavin-containing monooxygenase 4 shortened form ",56498,9.5,-0.099,3,"Microsome membrane;Endoplasmic reticulum membrane\n","Monooxygenase, Oxidoreductase",41,1,"R.NAILTQWDR.T"]
["IPI00206174","Cyp2a2 Cytochrome P450 2A2",56480,7.71,-0.085,1,"Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane","Highly active in the 15-alpha-hydroxylation of testosterone.",254,8,"R.NFIDSFLIR.M,R.FSNLAPLGIPR.R，K.YLPGPQQQIIK.V，R.YGPVFTIHLGPR.R，R.QNHSTLDPNSPR.N，K.EALVDQAEEFSGR.G，\nK.MPYTQAVINEIQR.F,K.VRQNHSTLDPNSPR.N\n"," "]
["IPI00324707","Cyp2c12 Cytochrome P450 2C12, female-specific",56453,8.38,-0.122,1,"Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane","This P450 is active in 15-beta-hydroxylation of steroid sulfates. ",412,13,"R.SLGMGKR.T,K.GLGISFSR.G，R.QSISNFSK.T，R.HFTVNTLR.S， K.VQEEIGQVIGR.H， R.DFIDYFLIQR.C，K.EALIDYGEEFSGR.G，K.SLSDPKDIDINSIR.S，K.IKEHEESLDVSNPR.D， R.SEFSSIPPTFQLCFIPV.- ，K.FIIGCAPCNVICSIIFQNR.F，R.GKLPPGPTPLPIFGNFLQIDMK.D，K.TYGPVFTLYFGSQPTVVLHGYEAVK.E\n "," "]
["IPI00325874","Cyp2c13 Cytochrome P450 2C13, male-specific",56337,6.76,-0.143,1,"Endoplasmic reticulum membrane; Peripheral membrane protein;Microsome membrane","Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. ",208,5,"R.SPCMQDR.S,R.QSLTNFSK.T，K.GTIEDKVQEEAK.W，K.IKEHEESLDVSNPR.D，K.LPPGPTPLPIIGNFFQVDMK.D \n"," "]
["IPI00551812","Atp5b ATP synthase subunit beta, mitochondrial",56318,5.18,0.034,0,"Mitochondrion;Mitochondrion inner membrane","Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. ",1062,16,"K.ILQDYK.S ,K.VLDSGAPIK.I，K.IGLFGGAGVGK.T， K.ADKLAEEHGS.-，  K.VVDLLAPYAK.G ，R.IMNVIGEPIDER.G ，\nR.FTQAGSEVSALLGR.I，K.TVLIMELINNVAK.A ，R.LVLEVAQHLGESTVR.T ，R.IMDPNIVGSEHYDVAR.G ，\nK.VLDSGAPIKIPVGPETLGR.I，R.DQEGQDVLLFIDNIFR.F ，R.AIAELGIYPAVDPLDSTSR.I ，R.FLSQPFQVAEVFTGHMGK.L + Oxidation (M) ，R.IPSAVGYQPTLATDMGTMQER.I ，R.TREGNDLYHEMIESGVINLK.D \n"," "]
["IPI00193234","Cyp2b2 Isoform 1 of Cytochrome P450 2B2",56239,6.8,-0.142,1,"Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane","Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. ",76,4,"R.ATLDPSAPR.D,R.DFIDTYLLR.M，R.FADLAPIGLPHR.V，K.MPYTDAVIHEIQR.F\n"," "]
["IPI00858382","Krt83 LOC681126 protein",56146,6.06,-0.414,0,"Keratin filament","Structural molecule activity",41,3,"R.FLEQQNK.L,R.LTAEIENAK.C,R.FAAFIDKVR.F"," "]
["IPI00196696","Cyp2a1 Cytochrome P450 2A1",56073,9.08,-0.157,1,"Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane","Highly active in the 7-alpha-hydroxylation of testosterone, progesterone and androstenedione. ",393,13,"R.NFIDSFLIR.M,R.ILEEAGYLIK.M，R.FSNLAPLGIPR.R，R.GEQATYNTLFK.G，K.YLPGPQQQIIK.V， K.VHEEIEQVIGR.N， \nR.YGPVFTIHLGPR.R，R.QNHSTLDPNSPR.N，K.EALVDQAEEFSGR.G， K.MPYTQAVINEIQR.F， K.VRQNHSTLDPNSPR.N， \nK.GTDVFPILGSLMTDPK.F，K.LEDINESPKPLGFTR.I\n "," "]
["IPI00189751","Cyp2b15;Cyp2b12 Cytochrome P450 2B12",56046,8.15,-0.093,0,"Intracellular membrane-bounded organelle","Heme binding,iron ion binding,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen.",76,3,"R.ATLDPSAPR.D,R.DFIDTYLLR.M,K.MPYTDAVIHEIQR.F"," "]
["IPI00475946","Tf Isoform 2 of Serotransferrin",55971,7.14,-0.252,0,"Basement membrane;extracellular space\n","Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.\n",73,5,"K.VAQEHFGK.G,K.TVLPADGPR.L，R.VSTVLTAQK.D，K.ASDSSINWNNLK.G，R.NGDGKEDLIWEILK.V\n"," "]
["IPI00208128","Cyp2t1 Cytochrome P450 monooxygenase CYP2T1",55878,6.19,-0.076,1,"Membrane","Heme binding,iron ion binding,monooxygenase activity,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen.",44,1,"R.YGLLIMLK.Y"]
["IPI00471781","LOC687052;Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1",55684,9.12,-0.088,2,"Intracellular membrane-bounded organelle","Heme binding,iron ion binding,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen.",59,2,"R.DLGMGK.R + Oxidation (M),R.YALLLLLK.Y "," "]
["IPI00210431","Dhcr7 7-dehydrocholesterol reductase",54861,8.64,0.242,6,"Endoplasmic reticulum membrane; Multi-pass membrane protein","Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC). ",197,8,"R.LLPGIF.-,K.TPPVTAK.A，R.YVAAVPYR.L，R.ASLADIWAK.T，K.AESQGQWGR.A， K.LLVSGFWGVAR.H， \nK.AIECSYTSADGLK.H ，R.FLPGYVGGVQEGAITPAGIVNK.Y\n "," "]
["IPI00364948","Aldh3a2 Fatty aldehyde dehydrogenase",54503,7.56,-0.101,1,"Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side \n","Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.",790,17,"K.SLLEGQK.I,K.IVMEAAAK.H，K.ASPDYER.I，K.IVMEAAAK.H + Oxidation (M)，R.YPPNSESK.V，K.GLKGESVNK.L，R.LQQLEALR.R，R.LQQLEALRR.M，K.LRYPPNSESK.V，K.HLTPVTLELGGK.S，K.IAFGGETDEATR.Y，K.NVEEAINFINDR.E，\nR.EKDILAAIAADLSK.S，R.FDHILYTGNTAVGK.I，R.YIAPTILTDVDPNSK.V，K.VMQEEIFGPILPIVSVK.N，\nK.VMQEEIFGPILPIVSVK.N + Oxidation (M)\n"," "]
["IPI00777611","54 kDa protein ",54454,5.36,-0.616,0,"Unknown","Unknown",41,3,"R.FQNVAK.E,K.YLNFVK.G，K.NLLHVTDTGVGMTR.D + Oxidation (M)\n"," "]
["IPI00214787","Slc16a1 Monocarboxylate transporter 1",53831,4.91,-0.009,2,"Cell membrane; Multi-pass membrane protein","Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.",67,1,"K.SDANTDLIGGSPK.G "," "]
["IPI00471577","Uqcrc1 Cytochrome b-c1 complex subunit 1, mitochondrial",53500,5.57,-0.159,0,"Mitochondrion inner membrane ","This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. ",97,4,"R.MVLAAAGGVK.H ,K.NRPGNALEK.E,R.TDLTDYLSR.H ,R.LCTSATESEVTR.G"," "]
["IPI00205022","Nucb1 Nucleobindin-1",53474,5.04,-1.022,0,"Golgi apparatus › cis-Golgi network membrane; Peripheral membrane protein; Lumenal side; Cytoplasm","Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis.\n",41,1,"K.LDELKR.Q"]
["IPI00209690","Ephx1 Epoxide hydrolase 1",52719,8.59,-0.312,1,"Intracellular membrane-bounded organelle","A protein that exhibits enzyme binding; epoxide hydrolase activity;",316,19,"R.LGFQK.F,K.FSTWTK.S，K.VVSYWR.N ，K.LLAQDIR.K ，K.GLNSVATAR.I ，R.ASPPLEGSR.F， K.VFYSIMR.E，K.IIPLLTDPK.S，K.KGLNSVATAR.I ，R.ELEDGGLER.K，K.LISYSYMER.G ，R.GGHFAAFEEPK.L， R.FHYGFNSNYMK.K， \nR.SFYTMTPLLGQR.F，K.QVEILNQYPHFK.T，K.SEYRELEDGGLER.K，K.VETSDEEIKDLHQR.I，K.VFVPTGFSAFPSELLHAPEK.W， \nR.DKEETLPLGDGWWGPGSKPSAK.E\n "," "]
["IPI00205639","Smad1 Mothers against decapentaplegic homolog 1",52713,6.9,-0.587,0,"Cytoplasm; Nucleus","Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) By similarity. Has been shown to be also activated by TGF-beta (transforming growth factor) type I receptor kinase in rat intestinal epithelial cells (IEC 4-1). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. ",42,1,"K.GAMEELEK.A"]
["IPI00231341","Sec61a1 Protein transport protein Sec61 subunit alpha isoform 1",52687,8.3,0.563,10,"Endoplasmic reticulum membrane; Multi-pass membrane protein ","Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane- bound ribosomes, either directly or through adaptor proteins. ",106,3,"R.VILASNR.G ,K.IIEVGDTPK.D,R.GQYNTYPIK.L "," "]
["IPI00382258","Steap4 Ab1-219",52516,9.3,0.15,4,"Endosome (ortholog); extracellular vesicular exosome (ortholog); plasma membrane (ortholog) ","A protein that exhibits cupric reductase activity (ortholog); ferric-chelate reductase (NADPH) activity (ortholog);",51,2,"R.VLIDVSNNQK.M,R.TLGLTPLDQGSLVAAK.E "," "," "]
["IPI00198467","Hadhb Trifunctional enzyme subunit beta, mitochondrial",51667,9.5,-0.073,0,"Mitochondrion (By similarity);Mitochondrion inner membrane (By similarity); Mitochondrion outer membrane (By similarity);Endoplasmic reticulum"," A protein that exhibits 3-hydroxyacyl-CoA dehydrogenase activity; acetyl-CoA C-acyltransferase activity; enoyl-CoA hydratase activity; ",74,3,"R.LVMAAANR.L,R.LAAAFAVSR.M , K.NIVVVEGVR.I "," "]
["IPI00555278","Gulo L-gulonolactone oxidase",51267,6.83,-0.199,1,"Microsome membrane; Single-pass membrane protein; Endoplasmic reticulum membrane","Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L- ascorbate. ",96,8,"R.VLQVDK.E ,K.FCDIR.E，K.EALLELK.A，R.VLQVDKEK.K，R.NADVFQAAR.V，K.GVQFQNWAK.T，K.VVAHYPVEVR.F， \nR.GDDILLSPCFQR.D \n"," "]
["IPI00388687","RGD1561141 similar to solute carrier family 25 (mitochondrial carrier, Aralar), member 12",51130,7.21,-0.01,0,"Mitochondrial inner membrane (ortholog); mitochondrion (ortholog)","Binding;calcium ion binding",63,2,"R.LQVAGEITTGPR.V,R.WFYIDFGGLKPSGSEPTPK.S"," "," "]
["IPI00189795","Tuba1a Tubulin alpha-1A chain",50788,4.94,-0.229,0,"Cytoplasm › cytoskeleton \n","Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.\n",47,1,"R.AVFVDLEPTVIDEVR.T"," "]
["IPI00214892","LOC493574 Isoform 1 of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein",50016,5.69,0.002,1,"Membrane","Nucleotidyltransferase, Transferase",41,1,"R.ISLAEAGATR.H"]
["IPI00769119","Ugt2b37 similar to UDP-glucuronosyltransferase 2B5 precursor",49897,6.64,-0.008,1,"Microsome membrane; Single-pass membrane protein Reviewed prediction; Endoplasmic reticulum membrane","Glucuronosyltransferase activity",214,9,"K.SDLFNALK.E ,K.GAAVTLNIR.T，K.AEMWLIR.S，K.IPATLGPNTR.V，K.TILDELVQR.G，K.LVDAWTYELQR.D， \nK.WLPQNDLLGHPK.T，K.ANAVAWALAQIPQK.V，K.NWDPFYTEILGRPTTLAETMGK.A\n"," "]
["IPI00358278","Naf1 H/ACA ribonucleoprotein complex non-core subunit NAF1",49847,4.67,-0.872,0,"Cytoplasm; Nucleus","RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. ",51,2,"R.GRYSR.G,K.NFPLKTK.D  "," "]
["IPI00365929","Pdia6 protein disulfide isomerase A6",49129,5.05,-0.296,1,"Endoplasmic reticulum lumen (By similarity);Cell membrane (By similarity); Melanosome ","May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.",342,10,"K.LADKYK.K,R.QLVKDR.L，K.AASALKDVVK.V，K.GESPVDYDGGR.T，K.NKPEDYQGGR.T，R.TGEAIVDAALSALR.Q，\nK.GSFSEQGINEFLR.E，K.LAAVDATVNQVLASR.Y，K.IFQKGESPVDYDGGR.T，K.VGAVNADKHQSLGGQYGVQGFPTIK.I\n"," "]
["IPI00471645","Ddost Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit",49093,5.62,-0.003,2,"Endoplasmic reticulum membrane; Single-pass type I membrane protein ","Essential subunit of N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.",280,8,"K.YSVQFK.L,R.GFELTFK.T，R.VGPVSHHR.V，K.SSLNPILFR.G，K.TADDPSLSLIK.Y，R.NTLLIAGLQAR.N，R.TLVLLDNLNVR.D，\nK.LPDVYGVFQFK.V\n"," "]
["IPI00188924","Uqcrc2 Cytochrome b-c1 complex subunit 2, mitochondrial",48423,9.16,-0.067,0,"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side ","This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex. ",233,8,"R.GGLGLAGAK.A,R.LASTLTTK.G，K.AVAFQNPQTR.I，K.EVAEQFLNIR.G， R.GNNTTSLLSQSVAK.G，R.MALVGLGVSHSILK.E， \nK.AVAQGNLSSADVQAAK.N ，R.YENYNYLGTSHLLR.L \n "," "]
["IPI00191728","Calr Calreticulin",48137,4.33,-1.099,0,"Endoplasmic reticulum lumen; Sarcoplasmic reticulum lumen ","Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. ",321,15,"K.NVLINK.D,K.FVLSSGK.F，K.HKSDFGK.F，R.FYALSAR.F，K.GKNVLINK.D，K.FYGDQEK.D，K.LFPGGLDQK.D，K.GLQTSQDAR.F，R.QIDNPDYK.G，K.FYGDQEKDK.G，K.KVHVIFNYK.G，K.DKGLQTSQDAR.F，K.EQFLDGDAWTNR.W，\nK.HEQNIDCGGGYVK.L，K.IDNSQVESGSLEDDWDFLPPK.K\n"," "]
["IPI00476295","Ahcy Adenosylhomocysteinase",48020,6.07,-0.052,0,"Cytoplasm;Melanosome ","Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. ",40,1,"K.VPAINVNDSVTK.S "]
["IPI00210920","Got2 Aspartate aminotransferase, mitochondrial",47683,9.13,-0.23,0,"Mitochondrion matrix; Cell membrane","Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. ",74,3,"R.VGASFLQR.F,R.KAEAQIAGK.N , R.IAATILTSPDLR.K "," "]
["IPI00202512","Rpl4 60S ribosomal protein L4",47569,10.92,-0.634,0,"Cytosolic large ribosomal subunit;nucleolus","Structural constituent of ribosome",110,6,"K.VYASQR.M,K.SPEIQR.A，K.KLEAAAAALAAK.S，R.NIPGITLLNVSK.L，R.FCIWTESAFR.K ，R.FCIWTESAFR.K \n "," "]
["IPI00372804","Sccpdh Probable saccharopine dehydrogenase",47514,9.02,-0.038,1,"Unknown","Oxidoreductase activity",41,2,"R.LPWAVAGR.S,K.GGGVFTPGAAFSR.T  "," "]
["IPI00464668","Irgm Immunity-related GTPase family M protein",46935,8.39,-0.134,0," late endosome (ortholog); lysosome (ortholog) ","A protein that exhibits GTP binding (inferred); hydrolase activity, acting on acid anhydrides (inferred); ",86,3,"R.NTLQTDLSNIR.C,R.DDDDMGECLKR.Y , R.IIGHEEDASAPTGVVR.T"," "," "]
["IPI00207010","Baat Bile acid-CoA:amino acid N-acyltransferase",46777,6.97,-0.044,0,"Peroxisome","Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs. ",168,5,"R.WYVAPGVTR.I,R.TFEETADKDSK.Y，K.LCHPYFPVEGK.V，K.VISSSLDSLILER.W，K.LTAVPLSALVDEPVHIR.V\n "," "]
["IPI00211127","Ass1 Argininosuccinate synthase",46752,7.63,-0.357,0,"Cell body fiber;cytoplasm;endoplasmic reticulum;lysosome;mitochondrial outer membrane;neuron projection;neuronal cell body;\nnucleus;perikaryon","Is indirectly involved in the control of blood pressure.",86,6,"K.VQVSVFK.G,R.IDIVENR.F，K.GQVYILGR.E，K.YVSHGATGK.G， K.NQAPPGLYTK.T ，K.APNTPDVLEIEFKK.G \n "," "]
["IPI00206080","Tm7sf2 Transmembrane 7 superfamily member 2",46700,8.83,0.474,7,"Integral component of membrane","Oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor.",56,3,"K.VAEGLELKDK.S ,R.QLLVSGWWGMVR.H , K.NPSDPSVAGLETIPTATGR.Q"," "]
["IPI00421933","Slc37a4 Solute carrier family 37 (Glucose-6-phosphate transporter), member 4",46593,9.07,0.54,11,"Integral component of membrane;intracellular membrane-bounded organelle","Glucose-6-phosphate transmembrane transporter activity",55,1,"K.FVSGVLSDQMSAR.W + Oxidation (M) "," "]
["IPI00395285","Rpl3 60S ribosomal protein L3",46392,10.22,-0.645,0,"Nucleus › nucleolus; Cytoplasm","The L3 protein is a component of the large subunit of cytoplasmic ribosomes.\n",111,8,"R.VAFSVAR.A,K.SLLVQTK.R，K.FIDTTSK.F，R.EVDRPGSK.V，K.IGQGYLIK.D ，R.HGSLGFLPR.K，K.NNASTDYDLSDK.S， \nK.TVFAEHISDECK.R \n "," "]
["IPI00567379","RGD1308874 Isoform 1 of Adipocyte plasma membrane-associated protein",46361,5.64,-0.108,0,"Cell surface (ortholog); extracellular vesicular exosome (ortholog); membrane (ortholog)","A protein that exhibits arylesterase activity (ortholog); ",92,6,"R.SPFICR.L,K.MSFVNDLTITR.D， K.MSFVNDLTITR.D + Oxidation (M)， R.VVKLENGEIETIAR.F ，K.EPPFMFGVLQPNTK.L ，\nR.LFENQLNGPESIVNIGDVLFTGTADGR.V \n "," "]
["IPI00214480","Fah Fumarylacetoacetase",46231,6.67,-0.185,0,"Extracellular vesicular exosome (ortholog)","Fumarylacetoacetase activity,metal ion binding",57,3,"R.FGEPIPISK.A,K.AIDVGQGQTR.T , R.ASSVVVSGTPIR.R"," "]
["IPI00215009","Aadac Arylacetamide deacetylase",45835,7.26,-0.109,3,"Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity); Microsome membrane","Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Displays cellular triglyceride lipase activity in liver; Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores.",47,1,"K.IILGNTLLK.L "]
["IPI00212730","Lamp2 Lysosome-associated membrane glycoprotein 2",45591,8.02,0.048,1,"Cell membrane; Single-pass type I membrane protein;Endosome membrane","Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. ",68,2,"K.EQVVSVSR.T,R.TFQINTFNLK.V"," "]
["IPI00332027","Bhmt Betaine--homocysteine S-methyltransferase 1",45404,8.02,-0.355,0,"Cytoplasm","Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. ",75,4,"K.EATTEQQLR.A ,R.AIAEELAPER.G ,K.AGPWTPEAAVEHPEAVR.Q ,K.QGFIDLPEFPFGLEPR.V "," "]
["IPI00211507","Hpd 4-hydroxyphenylpyruvate dioxygenase",45312,6.29,-0.497,0,"Cytoplasm;Endoplasmic reticulum membrane; Peripheral membrane protein; Golgi apparatus membrane","Key enzyme in the degradation of tyrosine",51,2,"K.INYTGR.F,K.FAVLQTYGDTTHTLVEK.I  "," "]
["IPI00650097","Acaa1 acetyl-Coenzyme A acyltransferase 1",45269,8.53,0.047,0,"Peroxisome\n","Acetyl-CoA C-acyltransferase activity,palmitoyl-CoA oxidase activity \n",180,7,"R.GNPGNISSR.L,R.LLESDKAR.D，R.QVVTLLNELK.R， K.AEELGLPILGVLR.S， R.QKQDAFALASQQK.A ，\nK.DGGSTTAGNSSQVSDGAAAVLLAR.R ，K.TITVSQDEGVRPSTTMEGLAK.L + Oxidation (M) \n "," "]
["IPI00776466","Lass2 LAG1 homolog, ceramide synthase 2",45093,8.85,0.04,6,"Integral component of membrane","Unknown",48,2,"R.QSGLSGR.Q,K.QVEVDLLSR.Q  "," "]
["IPI00373541","RGD1560797 similar to glyceraldehyde-3-phosphate dehydrogenase",44994,8.84,-0.116,0,"Cytoplasm","NAD binding,NADP binding,glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity",60,2,"K.LTGMGFR.V + Oxidation (M) ,K.LISWYDNEYGYSNR.V"," "]
["IPI00393875","Cyp4a3 44 kDa protein",44641,6.5,-0.2,1,"Intracellular membrane-bounded organelle","A protein that exhibits alkane 1-monooxygenase activity; arachidonic acid monooxygenase activity; ",111,5,"K.VFDPSR.F ,R.LYPPVPSVSR.E ,R.ELSSPVTFPDGR.S,K.AQLQNEEELQK.A , R.KAQLQNEEELQK.A"," "," "]
["IPI00208970","Upb1 Beta-ureidopropionase",44584,6.47,-0.338,0,"Extracellular vesicular exosome (ortholog)","Beta-ureidopropionase activity",51,2,"R.VGLVQNR.I,R.ELAEAVKPNYSPNIVK.E "," "]
["IPI00206336","Lamp1 Lysosome-associated membrane glycoprotein 1",44397,8.31,-0.051,1,"Cell membrane; Single-pass type I membrane protein; Endosome membrane","Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. ",49,1,"K.GPDTVDSTTDIK.A"," "]
["IPI00422053","Gna13 Guanine nucleotide binding protein alpha 13",44326,8.41,-0.395,0,"Membrane; Lipid-anchor; Melanosome; Cytoplasm; Nucleus","Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.",47,1,"K.ILLLGAGESGK.S"]
["IPI00194550","Cth Cystathionine gamma-lyase",44262,8.2,-0.053,0,"Cytoplasm","Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. ",57,3,"R.ATLGISDTLIR.L,K.LLEAAITPQTK.L , K.LVWIETPTNPTLK.L"," "," "]
["IPI00562827","43 kDa protein",43787,8.3,-0.079,0,"Mitochondria","Binding",60,3,"K.TVDGPSGK.L,K.LISWYDNEYGYSNR.V,K.VIHDNFGIVEGLMTTVHAITATQK.T + Oxidation (M)"," "]
["IPI00208203","Peci Peroxisomal 3,2-trans-enoyl-CoA isomerase",43336,9.11,-0.242,0,"Peroxisome matrix; Mitochondrion ","Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates.",133,4,"K.DPGNEVK.L ,K.KDPGNEVK.L,K.AAEMLLFGK.K ,K.GILVTSEGGITK.I "," "]
["IPI00382202","Hp Isoform 2 of Haptoglobin",43075,6.11,-0.196,0,"Secreted","Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes.Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.  ",126,5,"R.IIGGSMDAK.G ,K.GSFPWQAK.M，R.SVVDIGLIK.L，K.DIAPTLTLYVGK.N ，K.GAVSPVGVQPILNK.H \n"," "]
["IPI00191176","Cyp2c6 Cytochrome P450PB-1",42587,7.21,-0.154,0,"Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane","Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. ",77,5,"R.VQEEAR.C ,K.VQEEIDR.V，K.VQEEIDRVVGK.H ，R.MPYTDAMIHEVQR.F，K.IKEHQESLDVTNPR.D\n"," "]
["IPI00208111","Hsd17b2 Estradiol 17-beta-dehydrogenase 2",42567,8.22,0.209,2,"Membrane; Single-pass type II membrane protein (Potential) ","Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Favors the oxidation of estradiol and testosterone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH.",40,6,"K.VFLPLLR.K,R.EMSNPDITPVLR.D，R.EMSNPDITPVLR.D + Oxidation (M) ，K.AVLVTGADSGFGHALAK.H，\nK.EIQENYGQEYVHTQK.L，R.LVNVSSMGAMIPFQMVAAYASTK.A \n "," "]
["IPI00189813","Acta1 Actin, alpha skeletal muscle",42366,5.23,-0.232,0,"Cytoplasm; cytoskeleton","Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. ",649,19,"K.IIAPPER.K,K.RGILTLK.Y，K.AGFAGDDAPR.A，R.DLTDYLMK.I，R.DLTDYLMK.I + Oxidation (M)，K.EITALAPSTMK.I，\nR.HQGVMVGMGQK.D，K.EITALAPSTMK.I + Oxidation (M)，R.HQGVMVGMGQK.D + Oxidation (M)，\nK.DSYVGDEAQSK.R，R.AVFPSIVGRPR.H，R.HQGVMVGMGQK.D + 2 Oxidation (M)，K.DSYVGDEAQSKR.G，\nK.QEYDEAGPSIVHR.K， K.IWHHTFYNELR.V，R.LDLAGRDLTDYLMK.I，K.SYELPDGQVITIGNER.F,R.VAPEEHPTLLTEAPLNPK.A, K.LCYVALDFENEMATAASSSSLEK.S + Oxidation (M)\n"," "]
["IPI00360356","Actbl2 actin, beta-like 2",42278,5.3,-0.203,0,"Cytoskeleton","Traffic",394,11,"K.IIAPPER.K,K.RGILTLK.Y，K.CDVDIRK.D，R.DLTDYLMK.I，R.DLTDYLMK.I + Oxidation (M)，R.HQGVMVGMGQK.D，\nR.HQGVMVGMGQK.D + Oxidation (M)，R.HQGVMVGMGQK.D + 2 Oxidation (M)，R.LDLAGRDLTDYLMK.I，\nR.SYELPDGQVITIGNER.F,K.DLYANTVLSGGSTMYPGIADR.M + Oxidation (M) \n"," "]
["IPI00896224","Actg1 Actin, cytoplasmic 2",42108,5.31,-0.199,0,"Cytoplasm; cytoskeleton","Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. ",858,23,"K.IIAPPER.K,K.RGILTLK.Y, K.CDVDIRK.D ,K.AGFAGDDAPR.A, R.DLTDYLMK.I, R.DLTDYLMK.I + Oxidation (M), \nR.GYSFTTTAER.E ,K.EITALAPSTMK.I ,R.HQGVMVGMGQK.D ,K.EITALAPSTMK.I + Oxidation (M) ,\nR.HQGVMVGMGQK.D + Oxidation (M), K.DSYVGDEAQSK.R ,R.AVFPSIVGRPR.H ,R.HQGVMVGMGQK.D + 2 Oxidation (M), \nK.DSYVGDEAQSKR.G ,K.IWHHTFYNELR.V ,K.QEYDESGPSIVHR.K ,R.LDLAGRDLTDYLMK.I ,K.SYELPDGQVITIGNER.F ,\nM.EEEIAALVIDNGSGMCK.A ,M.EEEIAALVIDNGSGMCK.A + Oxidation (M), R.VAPEEHPVLLTEAPLNPK.A, \nK.DLYANTVLSGGTTMYPGIADR.M \n "," "]
["IPI00189819","Actb Actin, cytoplasmic 1",42052,5.29,-0.2,0,"Cytoplasm; cytoskeleton","Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. ",64,3,"R.GYSFTTTAER.E ,K.EITALAPSTMK.I ,R.VAPEEHPVLLTEAPLNPK.A "," "]
["IPI00199635","RT1-A3 MHC class I protein",42033,7.02,-0.613,1,"MHC class I protein complex;integral component of membrane","Involved in the presentation of foreign antigens to the immune system. ",66,1,"R.YFDIAVSRPGLGEPR.F "," "]
["IPI00855220","RT1-EC2 MHC class Ia protein",42000,5.9,-0.544,1,"MHC class I protein complex;integral component of membrane","Involved in the presentation of foreign antigens to the immune system. ",66,1,"R.YFDIAVSRPGLGEPR.Y"," "]
["IPI00189068","Slc25a27 Uncoupling protein UCP-4, isoform c",41516,9.19,0.081,1,"Apical part of cell;integral component of membrane;mitochondrion;neuronal cell body","Transport",48,1,"K.ILAEGGIR.G"]
["IPI00207601","Hao1 Hydroxyacid oxidase 1",41227,6.92,-0.089,0,"Peroxisome","FMN binding,glycolate oxidase activity",132,5,"R.GDDAQEAVK.H,R.LTSLPIVVK.G, K.HGVDGILVSNHGAR.Q, K.SGANDQETLADNIR.A, K.GVQDVLEILKEEFR.L\n "," "]
["IPI00231726","Gnai3 Guanine nucleotide-binding protein G(k) subunit alpha",41066,5.5,-0.36,0,"Cytoplasm (By similarity); Cell membrane; Cytoplasm; cytoskeleton;centrosome","Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. ",49,4,"K.MFDVGGQR.S,R.NLREDGEK.A,K.LLLLGAGESGK.S,R.DGGVQACFSR.S\n"," "]
["IPI00231925","Gnai2 Guanine nucleotide-binding protein G(i), alpha-2 subunit",41043,5.28,-0.372,0,"Cytoplasm (By similarity); Cell membrane; Cytoplasm; cytoskeleton; centrosome","Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. ",136,5,"K.FEDLNK.R,K.MFDVGGQR.S, K.NLREDGEK.A, K.LLLLGAGESGK.S, R.AVVYSNTIQSIMAIVK.A \n "," "]
["IPI00231733","Gnai1 Guanine nucleotide-binding protein G(i), alpha-1 subunit",40889,5.69,-0.32,0,"Nucleus; Cytoplasm; Cell membrane;Cytoplasm › cytoskeleton › microtubule organizing center › centrosome","Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.",49,3,"K.MFDVGGQR.S,R.NLREDGEK.A,K.LLLLGAGESGK.S"," "]
["IPI00421326","Dnajb11 DnaJ homolog subfamily B member 11",40755,5.92,-0.556,1,"Endoplasmic reticulum lumen ","Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. ",69,2,"K.LVNEER.T,K.FQDLGAAYEVLSDSEK.R  "," "]
["IPI00561513","Ndufa10 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial",40753,7.64,-0.436,0,"Mitochondrion matrix","Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. ",87,5,"K.FYDNPK.S ,R.IYDSFR.E, K.SNDGNSYR.L, R.LQSWLYASR.L, R.VITVDGNICSGK.N\n"," "]
["IPI00476086","Atp6v0d1 RCG51062, isoform CRA_a",40731,4.89,-0.093,0,"Apical plasma membrane;axon terminus;centrosome;early endosome;lysosomal membrane;neuron projection;protein complex;\nproton-transporting V-type ATPase, V0 domain;synaptic vesicle","Hydrogen-exporting ATPase activity, phosphorylative mechanism,protein complex binding",202,7,"K.LKEQECR.N,R.ADDYEQVK.N, R.LYPEGLAQLAR.A, K.NVADYYPEYK.L, K.LLFEGAGSNPGDK.T, R.NIVWIAECIAQR.H, \nR.AFIITINSFGTELSKEDR.A \n "," "]
["IPI00210524","Lman2 RCG24303, isoform CRA_a",40709,6.46,-0.381,1,"Endoplasmic reticulum-Golgi intermediate compartment;membrane","Unknown",73,3,"K.LFQLTVER.T,K.DNVDDPTGNFR.G, R.NRDHDTFLAVR.Y "," "]
["IPI00360954","Nsdhl Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating",40671,8.99,-0.129,1,"Endoplasmic reticulum membrane; Single-pass membrane protein; Lipid droplet","Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis. ",284,13,"R.QGFDNPR.V,K.TVIETCK.E,R.AVLDANDPK.K, R.AVLDANDPKK.N, R.GYAVNVFDVR.Q, R.ILTGLNYEAPK.Y, R.DPQLVPVLIDAAR.K, K.TVIETCKEAGVQK.L, K.KGQVTGTDLINEVSK.A, K.NFLTAAIRPHGIFGPR.D, .GVSTVFHCASPPSNSNNK.E, \nK.AFHITNDEPIPFWTFLSR.I, R.VQFFIGDLCNQQDLYPALK.G \n "," "]
["IPI00331983","Adh1 Alcohol dehydrogenase 1",40532,8.52,0.214,0,"Cytoplasm","NAD binding;alcohol dehydrogenase (NAD) activity;drug binding;ethanol binding;retinol dehydrogenase activity;zinc ion binding",164,11,"R.TVLTF.- ,K.NLTQPK.G, K.IIAVDINK.D, K.GALLDGTSR.F, K.MVATGVCR.S, K.LVADFMAK.K, K.LVADFMAK.K + Oxidation (M), \nK.IDAAAPLDK.V ,K.INEAFDLLR.A, K.IIAVDINKDK.F, K.KFPLEPLITHVLPFEK.I \n"," "]
["IPI00209115","Slc25a3 Solute carrier family 25 (Mitochondrial carrier",40052,9.38,0.045,2,"Mitochondrion inner membrane; Multi-pass membrane protein","Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H+. May play a role regulation of the mitochondrial permeability transition pore (mPTP). ",103,8,"R.TVEALYK.F,K.FACFER.T, K.FVVPKPR.S, R.MQVDPQK.Y + Oxidation (M) ,K.GVAPLWMR.Q + Oxidation (M) ,K.FGFYEVFK.A ,\nK.GSTASQVLQR.L ,R.IQTQPGYANTLR.E \n "," "]
["IPI00471911","Aldob Fructose-bisphosphate aldolase B",40049,8.66,-0.264,0,"Cytoplasm › cytoskeleton › microtubule organizing center › centrosome › centriolar satellite","Fructose-bisphosphate aldolase activity,phosphatidylcholine binding",478,14,"K.GIVVGIK.L ,K.VLAAVYK.A, K.LSFSYGR.A, K.ATQEAFMK.R, K.ELSEIAQR.I, K.VENTEENRR.Q, R.FPALTSEQKK.E, \nK.LDQGGAPLAGTNK.E, R.ALQASALAAWGGK.A, K.ETTIQGLDGLSER.C, K.GILAADESVGTMGNR.L, K.GILAADESVGTMGNR.L + Oxidation (M), K.YTPEQVAMATVTALHR.T, R.ISDQCPSSLAIQENANALAR.Y \n"," "]
["IPI00231745","Fbp1 Fructose-1,6-bisphosphatase 1",40040,5.54,-0.126,0,"Cytoplasm","AMP binding;fructose 1,6-bisphosphate 1-phosphatase activity;metal ion binding",103,4,"K.DALQPGR.N,K.TSANEPSEK.D, K.DFDPAINEYIQR.K, K.TSANEPSEKDALQPGR.N\n "," "]
["IPI00210139","Otc Ornithine carbamoyltransferase, mitochondrial",39918,9.12,-0.257,0," Mitochondrion matrix\n ","Amino acid binding;ornithine carbamoyltransferase activity;phosphate ion binding;phospholipid binding",80,1,"R.KPEEVDDEVFYSPR.S"," "]
["IPI00193374","Slc10a1 Sodium/bile acid cotransporter",39725,9.12,0.645,7,"Membrane; Multi-pass membrane protein","The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. ",55,1,"K.AAATEDATPAALEK.G"," "]
["IPI00231264","Pon1 Serum paraoxonase/arylesterase 1",39699,5.06,0.051,0,"Secreted; extracellular space","Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification. ",46,3,"R.SSYQTR.L,K.IHVYEK.H,K.FQEEER.S  "," "]
["IPI00470304","Pon3 Serum paraoxonase/lactonase 3",39604,5.49,-0.105,0,"Secreted; extracellular space ","Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. ",107,4,"R.IFLMDLNEPYPK.A,R.IFLMDLNEPYPK.A + Oxidation (M), K.YPGMPSFAPDKPGR.I, K.LLIYNPEDPPGSEVLR.I \n "," "]
["IPI00555299","Pon1 paraoxonase 1",39561,5.06,0.051,0,"Secreted; extracellular space","Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification. ",252,12,"R.SLLHLK.T,R.SSYQTR.L,K.IHVYEK.H, K.FQEEER.S, K.SFDPSKPGK.I, K.LLIGTVFHR.A, K.ILLMDLNEK.E, \nK.ILLMDLNEK.E + Oxidation (M), R.IQSILSEDPK.V, K.YVYIAELLAHK.I, R.IFFYDSENPPGSEVLR.I, \nK.GIEAGAEDLEILPNGLTFFSTGLK.Y \n "," "]
["IPI00765365","Erlin1 SPFH domain family, member 1",39412,6.53,-0.33,1,"Endoplasmic reticulum membrane;protein complex","Involved in ER-associated ubiquitin-dependent protein catabolic process",150,3,"K.YQAIASNSK.I,R.ISEIEDAAFLAR.E,R.SVQTTLQTDEVK.N"," "]
["IPI00192572","Phyh Phytanoyl-CoA dioxygenase, peroxisomal",39077,8.75,-0.459,0,"Peroxisome","Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. ",50,2,"K.GTSQENIAR.E,K.GPLKPHDYPK.W  "," "]
["IPI00325146","Anxa2 Isoform Short of Annexin A2",38939,7.55,-0.526,0,"Secreted; extracellular space; extracellular matrix; basement membrane; Melanosome (By similarity)","Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. ",118,4,"R.KGTDVPK.W,K.TPAQYDASELK.A, K.GVDEVTIVNILTNR.S, K.GLGTDEDSLIEIICSR.T\n "," "]
["IPI00214398","Mosc2 MOSC domain-containing protein 2, mitochondrial",38851,8.95,-0.21,1,"Mitochondrion outer membrane; Peripheral membrane protein (By similarity); Peroxisome ","As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively. ",80,8,"R.LFGLDIK.G,R.VGDPVYR.M, R.LFGLDIK.G, R.LCDPSVK.S, R.LGLPGQPR.S, R.LVQFDTK.M, K.VWIYPIK.S, R.WFTSYLK.T \n "," "]
["IPI00209179","Cdc123 Cell division cycle protein 123 homolog",38812,4.5,-0.512,0,"Cytoplasm ","Required for S phase entry of the cell cycle.\n",48,1,"K.LIDFLK.L,K.LIDFLK.L"," "]
["IPI00480620","Bdh1 3-hydroxybutyrate dehydrogenase, type 1",38708,9.01,-0.235,0,"Mitochondrion matrix","Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase. ",655,14,"K.YFDEK.I,K.SFLPLLR.R, R.YEMHPLGVK.V + Oxidation (M), R.VVNISSMLGR.M + Oxidation (M), K.GFLVFAGCLLK.D, \nK.MWDELPEVVR.K + Oxidation (M), K.FGVEAFSDCLR.Y, R.MQVMTHFPGAISDK.I + 2 Oxidation (M) ,\nR.YHPMDYYWWLR.M + Oxidation (M), R.TIQLNVCNSEEVEK.A, K.AVLVTGCDSGFGFSLAK.H ,K.VSVVEPGNFIAATSLYSPER.I ,\nR.TIQLNVCNSEEVEKAVETVR.S ,K.METYCNSGSTDTSSVINAVTHALTAATPYTR.Y + Oxidation (M) \n "," "]
["IPI00393599","LOC690745 similar to MOCO sulphurase C-terminal domain containing 1",38508,8.78,-0.164,1,"Mitochondrial inner membrane (ortholog); mitochondrion (ortholog)"," A protein that exhibits molybdenum ion binding (ortholog); molybdopterin cofactor binding (ortholog); nitrate reductase activity (ortholog); ",90,2,"K.LPTFGQYFALENPGTIK.V,K.DLLLPITPPATNPLLQCR.V  "," "]
["IPI00203528","Stoml2 Stomatin-like protein 2",38504,8.74,-0.192,0,"Mitochondrion inner membrane; Mitochondrion intermembrane space;Cell membrane; Peripheral membrane protein; Membrane raft; Peripheral membrane protein","Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation.",105,2,"K.APVPGAQNSSEAR.R,R.DVQTTDTSIEELGR.V "," "]
["IPI00212655","Gnb1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1",38151,5.6,-0.231,0,"GTPase activity,protein binding,signal transducer activity;spectrin binding","Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. ",100,5,"K.VHAIPLR.S,R.AGVLAGHDNR.V, R.LLVSASQDGK.L,  K.LIIWDSYTTNK.V, R.KACADATLSQITNNIDPVGR.I\n "," "]
["IPI00204239","Gnb3 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3",38125,5.51,-0.077,0,"Cell body;neuron projection","Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.\n",59,2,"K.VHAIPLR.S,K.LLVSASQDGK.L"," "]
["IPI00212658","Gnb2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2",38048,5.6,-0.177,0,"Cytoplasm; perinuclear region ","Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. ",100,4,"K.VHAIPLR.S,R.AGVLAGHDNR.V,R.LLVSASQDGK.L,K.LIIWDSYTTNK.V \n"," "]
["IPI00201494","Erlin2 Erlin-2",37915,5.54,-0.172,1,"Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity)","Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway. ",150,3,"K.YKAIASNSK.I,K.ISEIEDAAFLAR.E , K.SVQTTLQTDEVK.N "," "]
["IPI00382270","Slc25a15 Ab1-114",37524,9.18,0.201,0,"Mitochondrial inner membrane (ortholog); mitochondrion (ortholog) ","INVOLVED IN transport (inferred); ",114,4,"R.TFLSIVK.N,K.MQTFPDLYR.G, K.IAASQNTVWSVVK.E, K.DGPLGFYHGLSSTLLR.E \n "," "]
["IPI00203823","RGD1562690 similar to L-lactate dehydrogenase A chain",36774,8.2,0.05,0,"Cytoplasm","L-lactate dehydrogenase activity,NAD binding,identical protein binding,kinase binding,lactate dehydrogenase activity,protein binding",67,3,"K.YSPQCK.L,K.DYSVTANSK.L,R.VIGSGCNLDSAR.F"," "]
["IPI00197711","Ldha L-lactate dehydrogenase A chain",36712,8.45,0.064,0,"Cytoplasm","L-lactate dehydrogenase activity,NAD binding,identical protein binding,kinase binding,lactate dehydrogenase activity,protein binding",81,3,"K.YSPQCK.L,K.LVIITAGAR.Q ,K.DYSVTANSK.L "," "]
["IPI00327518","Arg1 Arginase-1",36652,6.76,-0.203,0,"Cytoplasm","Arginase activity,manganese ion binding",105,3,"K.TLGIK.Y,K.TPEEVTR.T , K.TGLLSGLDIMEVNPTLGK.T "," "]
["IPI00198717","Mdh1 Malate dehydrogenase, cytoplasmic",36631,6.16,-0.059,0,"Cytoplasm","L-malate dehydrogenase activity,NAD binding,malate dehydrogenase activity",63,3,"K.LGVTADDVK.N,K.FVEGLPINDFSR.E , K.ELTEEKETAFEFLSSA.- "," "]
["IPI00207390","Anxa3 Annexin A3",36569,5.96,-0.487,0,"Unknown","Calcium ion binding,calcium-dependent phospholipid binding,phospholipase inhibitor activity",251,9,"R.LHQALK.G,K.LTFDEYR.N, K.TLINILTER.S, K.GAGTDEFTLNR.I, R.SEIDLLDIRR.E, R.GMGTDEDTLIEILTTR.T, \nR.GMGTDEDTLIEILTTR.T + Oxidation (M), R.GTINNYPGFNPSVDAEAIR.K ,K.HYGCSLYSAIQSDTSGDYR.T\n "," "]
["IPI00210874","Gpsn2 Synaptic glycoprotein SC2",36498,9.6,0.006,4,"Endoplasmic reticulum membrane; Multi-pass membrane protein ","Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids",81,2,"R.MPIIPFLL.- + Oxidation (M),K.LPVGTTATLYFR.D  "," "]
["IPI00566040","36 kDa protein",36397,8.98,-0.073,1,"Membrane","Oxidoreductase activity",41,2,"R.RKPAQAV.-,R.VLAACLTEK.G "," "]
["IPI00213659","Decr1 2,4-dienoyl-CoA reductase, mitochondrial",36395,9.08,-0.003,0,"Mitochondrion","Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA.",60,3,"K.SGVEAMNK.S + Oxidation (M) ,K.SLAAEWGR.Y ,K.ATAEEITSK.T "," "]
["IPI00362452","RGD1564958 similar to Glyceraldehyde-3-phosphate dehydrogenase",36271,8.05999999999987,-0.0844,0,"Cytoplasm","NAD binding,NADP binding,glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity\n\n",60,4,"K.TVDGPSGK.L,K.LTGMAFR.V + Oxidation (M),R.GAAQNIIPASTGAAK.A,K.LISWYDNEYGYSNR.V"," "]
["IPI00231968","Anxa4 Annexin A4",36213,5.41,-0.431,0,"Cell surface (ortholog); cytoplasm (ortholog); extracellular vesicular exosome (ortholog)","Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. ",84,3,"K.FLSILCSR.N,K.GDTSGDYRK.V ,K.SETSGSFEDALLAIVK.C  "," "]
["IPI00197696","Mdh2 Malate dehydrogenase, mitochondrial",36117,8.93,0.119,0,"Mitochondrion matrix","L-malate dehydrogenase activity,malate dehydrogenase (NADP+) activity,malate dehydrogenase activity,protein binding,\nprotein self-association",140,4,"K.HGVYNPNK.I,K.AGAGSATLSMAYAGAR.F + Oxidation (M), K.VDFPQDQLATLTGR.I, K.VAVLGASGGIGQPLSLLLK.N \n "," "]
["IPI00213401","Rdh7 Retinol dehydrogenase 7",36056,9.22,-0.038,0,"Microsome; Endoplasmic reticulum (Potential) ","Acts on retinol bound on cellular retinol-binding protein (CRBP). ",168,8,"R.LSDNLKK.L,K.TNVTNMER.L + Oxidation (M),R.VLAACLTEK.G,K.VAIIEPGGFK.T,R.VVNIASTMGR.M + Oxidation (M),\nK.TESIVAATQWVK.E,K.YGVEAFSDSLRR.E,K.TSDRLETVILDVTK.T\n"," "]
["IPI00554039","RGD1565368 similar to glyceraldehyde-3-phosphate dehydrogenase",36045,8.44,-0.125,0,"Cytoplasm","NAD binding,NADP binding,glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity\n\n",141,6,"K.TVDGPSGK.L,K.LTGMAFR.V + Oxidation (M), R.GAAQNIIPASTGAAK.A, R.VPTPNVSVVDLTCR.L, K.LISWYDNEYGYSNR.V, \nK.VIHDNFGIVEGLMTTVHAITATQK.T + Oxidation (M) \n "," "]
["IPI00195585","Rdh7 Retinol dehydrogenase 3",35982,9.14,-0.059,0,"Microsome;Endoplasmic reticulum (Potential) ","Acts on retinol bound on cellular retinol-binding protein (CRBP). Has higher activity with NADP rather than NAD. ",195,9,"R.LSDNLKK.L,K.TNVTNMER.L + Oxidation (M), R.VLAACLTEK.G, K.VAIIEPGGFK.T, R.VVNIASTMGR.M + Oxidation (M) ,\nK.TESIVAATQWVK.E ,K.YGVEAFSDSLRR.E ,K.TSDRLETVILDVTK.T ,R.GLWGLVNNAGISVPVGPNEWMR.K + Oxidation (M)\n "," "]
["IPI00231134","Gnb2l1 Guanine nucleotide-binding protein subunit beta-2-like 1",35853,7.6,-0.251,0,"Cell membrane; Peripheral membrane protein (By similarity); Cytoplasm (By similarity)","Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand- independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. ",108,3,"K.IWDLEGK.I,R.DETNYGIPQR.A , K.IIVDELKQEVISTSSK.A "," "]
["IPI00213735","Sfxn1 Sideroflexin-1",35808,9.21,0.018,2,"Mitochondrion membrane; Multi-pass membrane protein","Might be involved in the transport of a component required for iron utilization into or out of the mitochondria. ",44,2,"K.HVSPLIGR.F,R.LGESTNAAK.Q "," "]
["IPI00190701","Apoe Apolipoprotein E",35788,5.23,-0.707,0,"Secreted.","Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues. ",84,3,"R.AQALSDR.I,K.EVQAAQAR.L , K.AGAQEGAER.G"," "]
["IPI00471889","Anxa5 Annexin A5",35779,4.91,-0.322,0,"Z disc;cell projection;cytoplasm;extracellular space;intercalated disc;nucleus;plasma membrane;sarcolemma","This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. ",127,4,"R.TPEELR.A,K.VLTEIIASR.T, R.LYDAYELK.H, K.GLGTDEDSILNLLTAR.S\n "," "]
["IPI00364884","Ssr1 Translocon-associated protein subunit alpha",35778,4.35,-0.176,1,"Endoplasmic reticulum membrane; Single-pass type I membrane protein ","TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. ",55,2,"K.FLVGFTNK.G,K.GEDFPANNIVK.F "," "]
["IPI00566322","35 kDa protein",35372,5.6,0.011,0,"Unknown","Unknown",60,2,"K.TVDGPSGK.V,K.LISWYDNEYGYSNR.V"," "]
["IPI00365813","RGD1565338 similar to Voltage-dependent anion-selective channel protein 1",35360,5.92,-0.372,0," Mitochondrion outer membrane By similarity;Cell membrane By similarity\n "," Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis By similarity.\n",66,2,"R.VTQSNFAVGYK.T,K.VNNSSLIGLGYTQTLKPGIK.L"," "]
["IPI00206020","Lrrc59 Leucine-rich repeat-containing protein 59",35304,9.57,-0.781,1,"Microsome membrane; Single-pass type II membrane protein; Endoplasmic reticulum membrane","A protein that exhibits poly(A) RNA binding (ortholog); ",105,4,"K.AVQADQERER.Q,R.LVTLPVSFAQLK.N, R.LVNLQHLDLLNNR.L, K.WLDLKDNPLDPVLAK.V \n "," "]
["IPI00231365","Uox Uricase",35140,8.19,-0.45,0,"Peroxisome","Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin. ",621,22,"R.DIVLKK.F,K.VLHIQR.D, K.FAGPYDR.G, K.NTVHVLAK.F, R.DGKYHSIK.E, R.GEYSPSVQK.T, R.TGYGKDMVK.V, \nR.TGYGKDMVK.V + Oxidation (M) ,R.NGPPIIHSGIK.D ,R.CFATQVYCK.W ,K.TTQSGFEGFIK.D ,K.EVATSVQLTLR.S, \nR.AHVYVEEVPWK.R, R.DVDFEATWGAVR.D, K.DQFTTLPEVKDR.C, K.EEVLLPLDNPYGK.I, R.AHVYVEEVPWKR.F, \nK.FAGPYDRGEYSPSVQK.T, K.DYLHGDNSDIIPTDTIK.N,K.MGLINKEEVLLPLDNPYGK.I, K.MGLINKEEVLLPLDNPYGK.I + Oxidation (M), K.TTQSGFEGFIKDQFTTLPEVK.D \n "," "]
["IPI00764690","Mtch2 mitochondrial carrier homolog 2",35075,8.58,0.231,0,"Extracellular vesicular exosome (ortholog); membrane (ortholog); mitochondrial inner membrane (ortholog)","INVOLVED IN hepatocyte apoptotic process (ortholog); protein localization to mitochondrion (ortholog); regulation of mitochondrial membrane permeability involved in apoptotic process (ortholog); ",41,1,"R.GLFTGLTPR.L"]
["IPI00366247","Ttc35 Tetratricopeptide repeat protein 35",35018,7.02,-0.086,0,"Cytoplasm (ortholog); endoplasmic reticulum (ortholog); ER membrane protein complex (ortholog) ","INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; toluene",48,1,"R.ILQEDPTNTAAR.K"]
["IPI00764911","LOC687215 similar to Cytochrome P450 2B12",35004,6.19,-0.212,0," Endoplasmic reticulum membrane; Peripheral membrane protein;Microsome membrane","Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. This isozyme seems responsible for metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.\n",41,2,"R.FADLAPIGLPHR.V,K.MPYTDAVIHEIQR.F"," "]
["IPI00208645","Hsd17b12 Estradiol 17-beta-dehydrogenase 12",34990,9.69,0.093,1,"Endoplasmic reticulum membrane; Multi-pass membrane protein ","Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in females. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation. ",88,1,"K.GIFVQSVLPFFVATK.L "," "]
["IPI00569825","35 kDa protein",34876,9.42,0.012,2,"Mitochondrial inner membrane;membrane","Catalytic activity,binding ",222,13,"R.MMMQSGR.K,R.GNLANVIR.Y,K.TAVAPIER.V,R.GNLANVIR.Y,K.TAVAPIER.V,R.GNLANVIR.Y,K.GLGDCLVK.I,K.GAWSNVLR.G,\nK.QIFLGGVDK.R,K.EQGVLSFWR.G,K.QIFLGGVDKR.T,R.AAYFGIYDTAK.G,R.YFPTQALNFAFK.D\n"," "]
["IPI00361473","RGD1564051 similar to 60S ribosomal protein L5",34696,9.71,-0.729,0,"Cytoplasm (By similarity);Nucleus; nucleolus ","Required for rRNA maturation and formation of the 60S ribosomal subunits (By similarity). This protein binds 5S RNA. ",56,2,"K.NKYNTPK.Y,R.VTNRDIICQIAYAR.I"," "]
["IPI00230914","Rpl5 60S ribosomal protein L5",34665,9.75,-0.765,0,"Cytoplasm (By similarity); Nucleus; nucleolus ","Required for rRNA maturation and formation of the 60S ribosomal subunits (By similarity). This protein binds 5S RNA. ",92,5,"K.TDYYAR.K,K.NKYNTPK.Y, K.GAVDGGLSIPHSTK.R, R.VTNRDIICQIAYAR.I, R.IEGDMIVCAAYAHELPK.Y\n "," "]
["IPI00205157","Hadh Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial",34540,8.83,-0.142,0,"Mitochondrion matrix","Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA. ",59,2,"R.LLVPYLIEAIR.L,K.LGAGYPMGPFELLDYVGLDTTK.F + Oxidation (M) "," "]
["IPI00202971","Dhrs1 Dehydrogenase/reductase (SDR family) member 1",34507,8.5,0.025,0,"Endoplasmic reticulum;mitochondrial inner membrane","Oxidoreductase activity",45,1,"R.ATAQEAQSLGGR.C "," "]
["IPI00231261","Slc25a11 Mitochondrial 2-oxoglutarate/malate carrier protein",34393,9.89,0.101,1,"Mitochondrial inner membrane (ortholog); mitochondrion (ortholog); nucleus (ortholog) ","A protein that exhibits transporter activity; poly(A) RNA binding (ortholog); ",93,4,"R.MQLSGEGAK.T + Oxidation (M) ,R.LGIYTVLFER.L, R.LTGADGTPPGFLLK.A, R.AVVVNAAQLASYSQSK.Q \n"," "]
["IPI00231662","Cyb5r3 Isoform 1 of NADH-cytochrome b5 reductase 3",34381,8.56,-0.213,0,"Isoform 1: Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side; Mitochondrion outer membrane","Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.",254,6,"K.VYFKDTHPK.F,R.GPNGLLVYQGK.G, R.SSPAITLENPDIKYPLR.L, K.SVGMIAGGTGITPMLQVIR.A + 2 Oxidation (M), \nK.MSQYLENMNIGDTIEFR.G + 2 Oxidation (M), .IDGNLVIRPYTPVSSDDDKGFVDLVVK.V \n "," "]
["IPI00200147","Arbp 60S acidic ribosomal protein P0",34365,5.9,0.05,0,"Nucleus (By similarity); Cytoplasm (By similarity)","Ribosomal protein P0 is the functional equivalent of E.coli protein L10. ",263,7,"R.FLEGVR.N,K.SNYFLK.I, K.IIQLLDDYPK.C, R.GHLENNPALEK.L, K.CFIVGADNVGSK.Q, K.TSFFQALGITTK.I, \nR.AGAIAPCEVTVPAQNTGLGPEK.T \n "," "]
["IPI00563746","34 kDa protein",34266,9.23,-0.194,1,"Membrane","Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor \n",60,2,"K.TVDGPSGK.N,K.LISWYDNEYGYSNR.V"," "]
["IPI00327694","Slc25a1 Tricarboxylate transport protein, mitochondrial",34156,9.88,-0.069,1,"extracellular vesicular exosome (ortholog); mitochondrial inner membrane (ortholog); mitochondrion (ortholog)","A protein that exhibits citrate transmembrane transporter activity (inferred); ",94,6,"K.QGSNQAIR.F,R.ALTAAAPGSGK.A, R.GLSSLLYGSIPK.A, K.GTYQGLTATVLK.Q, R.NTLDCGVQILK.N, K.FIHDQTSSNPK.Y \n "," "]
["IPI00564294","34 kDa protein",34003,9.27,-0.156,2,"Membrane","Unknown",102,5,"K.TAVAPIER.V,R.GNLANVIR.Y,K.EQGVLSFWR.G,R.AAYFGIYDTAK.G,R.YFPTQALNFAFK.D\n"," "]
["IPI00382300","Rab1 Ac2-048",33985,9.72,-0.522,0,"Early endosome; endoplasmic reticulum membrane; Golgi membrane"," A protein that exhibits GTP binding; GTPase activity (ortholog); ",195,7,"K.SCLLLR.F,R.YASENVNK.L, R.TITSSYYR.G, R.MGPGATAGGAEK.S, R.MGPGATAGGAEK.S + Oxidation (M), K.LLLIGDSGVGK.S,\nK.LQIWDTAGQER.F\n "," "]
["IPI00389611","Rgn Regucalcin",33939,5.27,-0.31,0,"Cytoplasm","Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities. ",112,3,"R.QSGGYVATIGTK.F,R.VGVDAPVSSVALR.Q, R.YFAGTMAEETAPAVLER.H + Oxidation (M) "," "]
["IPI00363696","Hsd17b13 17-beta hydroxysteroid dehydrogenase 13",33815,9.45,0.236,0,"Secreted (Potential) ","Oxidoreductase activity",111,5,"K.SVDQVKK.E,K.HGVEETAAK.C, R.LVLWDISK.H, R.ALTAELDTLGK.T, R.LWPVLEPDEVAR.S \n "," "]
["IPI00189925","Napa Alpha-soluble NSF attachment protein",33627,5.3,-0.355,0,"Membrane; Peripheral membrane protein ","Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.",113,3,"K.VAGYAAQLEQYQK.A,K.NSQSFFSGLFGGSSK.I, K.HDAATCFVDAGNAFK.K"," "]
["IPI00390343","Rpl6 60S ribosomal protein L6",33598,10.78,-0.803,0,"Ribosome","Structural constituent of ribosome",76,1,"R.SSITPGTVLIILTGR.H"," "]
["IPI00231609","Rpl6-ps1 similar to 60S ribosomal protein L6",33582,10.74,-0.784,0,"Ribosome","Structural constituent of ribosome",364,8,"K.AGGDATAPR.A,K.KAGGDATAPR.A,K.AVDSQILPK.I, K.KPFSQHVR.R, R.YYPTEDVPR.K, K.AVPQLQGYLR.S, \nR.SSITPGTVLIILTGR.H, K.QLGSGLLLVTGPLALNR.V\n "," "]
["IPI00205413","Slc25a20 Mitochondrial carnitine/acylcarnitine carrier protein",33474,9.55,0.084,3,"Mitochondrion inner membrane; Multi-pass membrane protein ","Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. ",50,3,"R.EGITGLYR.G,K.SVHDLSVPR.V,R.EEGVTSLYK.G   "," "]
["IPI00231818","Sult2al1 Alcohol sulfotransferase A",33401,7.63,-0.246,0,"Cytoplasm","Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze sulfonation of hydroxysteroids and xenobiotics. ",41,3,"K.ICDFLGK.K,K.ETLQNVCNK.F,K.ITQSNAILR.Y "," "]
["IPI00231738","Asgr1 Asialoglycoprotein receptor 1",33398,5.77,-0.625,1,"Membrane; Single-pass type II membrane protein ","Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. ",100,6,"R.LLLHVK.Q ,K.QLVSDVR.S, K.ALTTQGER.V ,K.LVESQLEK.H ,R.WVCETELGK.A ,K.WVDGTDYETGFK.N\n"," "]
["IPI00363182","RGD1560896 similar to solute carrier family 25, member 5",33326,9.74,0.021,2," Mitochondrion inner membrane; Multi-pass membrane protein\n ","Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation By similarity.\n",234,11,"R.TQFWR.Y,R.MMMQSGR.K,K.GLGDCLVK.I,K.GAWSNVLR.G,R.TRLAADVGK.A,K.EQGVLSFWR.G,R.AAYFGIYDTAK.G,\nK.DFLAGGVAAAISK.T,R.AAYFGIYDTAK.G, K.DFLAGGVAAAISK.T ,R.YFPTQALNFAFK.D\n"," "]
["IPI00193277","Hsd17b11 Estradiol 17-beta-dehydrogenase 11",33316,8.87,0.261,0,"Cytoplasm (ortholog); lipid particle (ortholog)","A protein that exhibits steroid dehydrogenase activity (ortholog); ",201,2,"R.LTAYEFAK.L,K.MIFVPGSIALLTVLER.V + Oxidation (M)  "," "]
["IPI00190557","Phb2 Prohibitin-2",33292,9.83,-0.266,0,"Mitochondrion inner membrane; Cytoplasm; Nucleus","Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging. ",350,16,"R.AAQNISK.T,R.AQFLVEK.A ,K.MLGEALSK.N + Oxidation (M) ,K.TIATSQNR.I ,R.AQVSLLIR.R ,R.KISSPTGSK.D , R.EYTAAVEAK.Q ,R.LGLDYEER.V ,K.QVAQQEAQR.A ,R.VLPSIVNEVLK.S  ,K.IVQAEGEAEAAK.M ,R.ESVFTVEGGHR.A ,\nK.LLLGAGAVAYGVR.E ,R.IPWFQYPIIYDIR.A ,R.IGGVQQDTILAEGLHFR.I ,R.VLSRPNAQELPSMYQR.L \n "," "]
["IPI00231927","Slc25a4 ADP/ATP translocase 1",33196,9.81,0.035,4,"Mitochondrion inner membrane; Multi-pass membrane protein ","Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. ",170,11,"R.MMMQSGR.K,R.GNLANVIR.Y,K.TAVAPIER.V,R.GNLANVIR.Y,K.TAVAPIER.V,R.GNLANVIR.Y,K.GAWSNVLR.G,R.TRLAADVGK.G, K.LLLQVQHASK.Q,R.YFPTQALNFAFK.D,K.GLYQGFSVSVQGIIIYR.A \n"," "]
["IPI00326195","Pecr Peroxisomal trans-2-enoyl-CoA reductase",33116,8.89,0.007,0,"Peroxisome","Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity ",225,8,"R.AGVYNLTK.T,R.LTAAVDELR.A ,R.KEEEVNNLVK.S ,K.TMALTWASSGVR.I + Oxidation (M) ,R.ELLHLGCNVVIASR.K ,\nR.ASQPPSSSTQVTAIQCNIR.K ,K.INFLVNNAGGQFMAPAEDITAK.G + Oxidation (M) ,K.SGQSYLAAGLLQNQVAVVTGGATGIGK.A \n "," "]
["IPI00200466","Slc25a5 ADP/ATP translocase 2",33108,9.74,0.021,2,"Mitochondrion inner membrane; Multi-pass membrane protein ","Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. ",297,14,"R.TQFWR.Y,R.MMMQSGR.K ,R.GNLANVIR.Y ,K.TAVAPIER.V ,R.GNLANVIR.Y ,K.GAWSNVLR.G ,R.TRLAADVGK.A , K.QIFLGGVDK.R ,K.EQGVLSFWR.G ,K.QIFLGGVDKR.T ,K.LLLQVQHASK.Q ,R.AAYFGIYDTAK.G ,K.DFLAGGVAAAISK.T ,\nR.YFPTQALNFAFK.D \n "," "]
["IPI00208495","33 kDa protein",32980,10.63,-0.762,0,"Ribosome","Structural constituent of ribosome",312,8,"R.ARPAGAVK.K,K.AGGDATAPR.A,K.KAGGDATAPR.A,K.AVDSQILPK.I,K.KPFSQHVR.R,R.YYPTEDVPR.K,K.AVPQLQGYLR.S,\nR.SSITPGTVLIILTGR.H\n "," "]
["IPI00215107","Rpsa 40S ribosomal protein SA",32917,4.8,-0.308,0,"Cell membrane; Cytoplasm; Nucleus (By similarity)","Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA. ",151,3,"R.LLVVTDPR.A,K.FAAATGATPIAGR.F , R.AIVAIENPADVSVISSR.N "," "]
["IPI00785564","Sdhb Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial",32607,8.96,-0.37,0,"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side ","Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). ",52,1,"K.DLVPDLSNFYAQYK.S "," "]
["IPI00371173","Mlec Malectin",32569,5.38,-0.22,1,"Endoplasmic reticulum membrane; Single-pass type I membrane protein","Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation. ",41,1,"R.STPEDQILYQTER.Y "," "]
["IPI00208061","Atp1b3 Sodium/potassium-transporting ATPase subunit beta-3",32151,8.08,-0.261,1,"Cell membrane; Single-pass type II membrane protein; Melanosome","This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-3 subunit is not known.\n",40,1,"K.LFIYNPTSGEFLGR.T"," "]
["IPI00211096","Hsd11b1 Isoform 11-HSD1A of Corticosteroid 11-beta-dehydrogenase isozyme 1",32091,8.55,0.149,0,"Apical part of cell; cytoplasm; intracellular membrane-bounded organelle ","A protein that exhibits 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity; NADP binding; oxidoreductase activity;",377,16,"R.DLFVSN.- ,R.FVVEAGK.L ,K.VIVTGASK.G ,R.SEEGLQK.V ,K.KVIVTGASK.G ,R.IMEFLSLR.S ,K.MGAHVVLTAR.S , R.KDEVYYDK.S ,K.EECALEIIK.G ,K.FALDGFFSTIR.K ,K.ETSGIILSQAAPK.E ,K.MTQPLIASYSASK.F ,K.SSWTPLLLGNPGR.R ,\nK.FALDGFFSTIRK.E ,K.MTQPLIASYSASK.F + Oxidation (M) ,K.SSWTPLLLGNPGRR.I \n"," "]
["IPI00209363","Slc25a10 Solute carrier family 25 (Mitochondrial carrier",31890,9.42,0.091,0,"Mitochondrial inner membrane (ortholog); mitochondrion (ortholog); nucleus (ortholog)","A protein that exhibits antiporter activity; malate transmembrane transporter activity; phosphate ion transmembrane transporter activity; ",306,8,"K.LPLSQR.R,K.LGPQAFFK.G ,K.LFSGATMASSR.G ,K.VHLQTQQEVK.L ,K.DSQGPLPFYSK.V ,R.NYSHALDGLYR.V ,\nR.GALVTVGQLSCYDQAK.Q ,K.VLLGGISGLTGGFVGTPADLVNVR.M \n "," "]
["IPI00764430","LOC681117 similar to ribosomal protein L6",31839,10.61,-0.535,0,"Ribosome","Structural constituent of ribosome",84,3,"R.ARPAGAVK.K,K.KPFSQHVR.R,K.QLGSGLLLVTGPLALNR.S"," "]
["IPI00768666","similar to Ras-related protein Rab-1B",31680,5.75,-0.287,0,"Membrane; Lipid-anchor; Cytoplasmic side;Cytoplasm","Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. ",138,6,"K.SCLLLR.F,R.YASENVNK.L,R.TITSSYYR.G,K.LLLIGDSGVGK.S,K.LQIWDTAGQER.F,K.VVDNTTAKEFADSLGVPFLETSAK.N \n"," "]
["IPI00207891","Vdac3 31 kDa protein",31292,8.91,-0.296,0,"Mitochondrion outer membrane ","Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.",50,1,"K.ASGNLETK.Y "]
["IPI00208209","Prdx4 Peroxiredoxin 4",31216,6.18,-0.249,0,"Cytoplasm (By similarity); Secreted","Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.",58,6,"R.SVDETLR.L ,R.LVQAFQYTDK.H ,R.VSVADHSLHLSK.A ,R.GLFIIDDKGVLR.Q ,R.IPLLSDLNHQISK.D ,\nK.SINTEVVACSVDSQFTHLAWINTPR.R\n"," "]
["IPI00367843","Peg12 similar to GSK-3 binding protein FRAT1",31055,8.29,-0.559,0,"Unknown","Unknown",43,1,"R.GSHLETR.T"]
["IPI00421874","Vdac1 Voltage-dependent anion-selective channel protein 1",30851,8.62,-0.423,0,"Mitochondrion outer membrane (By similarity); Cell membrane","Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. ",86,4,"K.VNGSLETK.Y ,R.VTQSNFAVGYK.T ,R.WTEYGLTFTEK.W ,K.VNNSSLIGLGYTQTLKPGIK.L\n"," "]
["IPI00370387","RGD1560058 hypothetical protein LOC287559",30530,5.5,0.106,0,"Membrane (inferred) ","INTERACTS WITH (Z)-3-butylidenephthalide (ortholog); 17beta-estradiol (ortholog); 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ortholog)",172,2,"K.DLQNVNITLR.I,K.AAELIANSLATAGDGLIELR.K"," "]
["IPI00766422","LOC684016 similar to esterase 2",30505,5.27,-0.429,0,"Endoplasmic reticulum lumen","Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant By similarity.\n",41,1,"K.FWANFAR.N"]
["IPI00202616","Ndufs3 NADH dehydrogenase (ubiquinone) Fe-S protein 3",30379,7.06,-0.325,0,"Mitochondrial respiratory chain complex I","NADH dehydrogenase (ubiquinone) activity",61,1,"R.VVAEPVELAQEFR.K "," "]
["IPI00199543","Rpl7 60S ribosomal protein L7",30367,10.87,-0.557,0,"Ribosome","Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs ",163,3,"K.LSSPR.G ,R.IALTDNSLVAR.S,R.IVEPYIAWGYPNLK.S "," "]
["IPI00889339","Rpl7 Rpl7 protein",30351,10.87,-0.578,0,"Ribosome","RNA binding",83,2,"K.ASVNMLR.I + Oxidation (M) ,K.VAAAPGTLK.K "," "]
["IPI00231693","Rps3a 40S ribosomal protein S3a",30154,9.75,-0.626,0,"Cytoplasm (By similarity); Nucleus (By similarity)","May play a role during erythropoiesis through regulation of transcription factor DDIT3 ",76,6,"K.IASDGLK.G,K.MMEIMTR.E + 3 Oxidation (M), K.TSYAQHQQVR.Q ,K.LMELHGEGGSSGK.T + Oxidation (M), \nR.EVQTNDLKEVVNK.L ,R.VFEVSLADLQNDEVAFRK.F \n "," "]
["IPI00210851","Srd5a1 Isoform Long of 3-oxo-5-alpha-steroid 4-dehydrogenase 1",29989,9.01,0.359,3,"Microsome membrane; Multi-pass membrane protein; Endoplasmic reticulum membrane","Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. ",77,8,"R.LGNLPNR.V,K.FEDYPK.S ,R.SVGSPYGR.Y ,R.KPGETGYK.I ,R.KILIPFVL.- ,R.TLVFPVLIR.G ,R.YSPQWPGIR.V ,R.KPGETGYKIPR.G \n "," "]
["IPI00764736","LOC684838 similar to 60S ribosomal protein L7a",29975,10.52,-0.427,0,"Ribosome","Involved in ribosome biogenesis",66,1,"K.NFGIGQDIQPK.R"]
["IPI00211756","Phb Prohibitin",29859,5.57,0.009,0,"Mitochondrion inner membrane","Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging. ",650,12,"K.VFESIGK.F,K.QVAQQEAER.A ,K.AAIISAEGDSK.A ,R.FDAGELITQR.E ,K.DLQNVNITLR.I ,R.VLPSITTEILK.S ,R.ILFRPVASQLPR.I , R.IYTSIGEDYDER.V ,R.KLEAAEDIAYQLSR.S ,R.NITYLPAGQSVLLQLPQ.- ,K.AAELIANSLATAGDGLIELR.K ,\nR.IYTSIGEDYDERVLPSITTEILK.S \n "," "]
["IPI00193425","Bsg Isoform 2 of Basigin",29852,5.12,-0.22,1,"Cell membrane; Single-pass type I membrane protein (By similarity); Melanosome (By similarity)","Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. ",83,1,"R.GNINVEGPPR.I "]
["IPI00475474","Rps4x 40S ribosomal protein S4, X isoform",29807,10.16,-0.33,0,"Cytoplasm (By similarity)","A protein that exhibits poly(A) RNA binding (ortholog); structural constituent of ribosome (ortholog); ",80,5,"R.IGVITNR.E,R.LTIAEER.D ,R.LSNIFVIGK.G ,R.ECLPLIIFLR.N ,R.TDITYPAGFMDVISIDK.T + Oxidation (M) \n "," "]
["IPI00362949","Uqcrfs1 Cytochrome b-c1 complex subunit Rieske, mitochondrial",29712,9.04,-0.108,0,"Mitochondrion inner membrane ","Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex.  ",105,6,"R.GKPLFVR.H,K.LSDIPEGK.N ,R.AEVLDSTK.S ,R.RAEVLDSTK.S,K.EIDQEAAVEVSQLR.D ,K.EIDQEAAVEVSQLRDPQHDLER.V \n "," "]
["IPI00366343","RGD1559149 similar to 60S ribosomal protein L7a",29654,10.43,-0.544,0,"Ribosome","Involved in ribosome biogenesis",66,1,"K.NFGIGQDIQPK.R"]
["IPI00206222","29 kDa protein",29278,6.36,-0.084,0,"Unknown","Unknown",82,2,"R.VLPSITTEILK.L,K.AAELIANSLATAGDGLIELR.K"," "]
["IPI00777232","RT1-CE7 29 kDa protein",29191,6.2,-0.48,1,"Membrane","INTERACTS WITH ammonium chloride; bis(2-ethylhexyl) phthalate; bisphenol A",64,1,"R.FDSDAENPR.Y"]
["IPI00779472","RT1-CE1 29 kDa protein",28965,6.01,-0.391,1,"Membrane","INTERACTS WITH 17alpha-ethynylestradiol; ammonium chloride; 17beta-estradiol (ortholog)",64,1,"R.FDSDAENPR.Y"]
["IPI00196107","Atp5f1 ATP synthase subunit b, mitochondrial",28965,9.39,-0.137,0,"Mitochondrion; Mitochondrion inner membrane ","Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. ",236,9,"K.AQQALVQK.R,K.KAQAQPIM.- + Oxidation (M) ,K.IAQLEEIK.Q ,K.QIQDAINR.E ,K.AQQALVQKR.H ,R.HYLFDVQR.N ,\nK.HVIQSISAQQEK.E ,R.LGLIPEEFFQFLYPK.T ,K.HVIQSISAQQEKETIAK.C \n "," "]
["IPI00366256","Derl1 RCG59470, isoform CRA_a",28930,9.54,0.396,5,"Early endosome (ortholog); endoplasmic reticulum (ortholog); Hrd1p ubiquitin ligase complex (ortholog)","A protein that exhibits MHC class I protein binding (ortholog); ",44,1,"R.NFLSTPQFLYR.W "]
["IPI00654464","Mettl7a Methyltransferase like 7A",28694,8.8,0.146,1,"Membrane","Methyltransferase activity",48,1,"R.VTCIDPNPNFEK.F "]
["IPI00454263","Anxa3 LRRGT00047",28539,5.73,-0.372,0,"Axon; dendrite; neuronal cell body ","Calcium ion binding,calcium-dependent phospholipid binding,phospholipase inhibitor activity",73,2,"K.GAGTDEFTLNR.I,R.SEIDLLDIRR.E"," "]
["IPI00369550","28 kDa protein",28458,6.93,-0.352,0,"Unknown","Unknown",52,1,"K.NLNQALLDLHALGSAR.T"," "]
["IPI00777725","28 kDa protein",28443,10.52,-0.677,0,"Ribosome","Structural constituent of ribosome",80,5,"R.HLYLR.G,R.KLTPQGQR.D ,R.IAGQVAAANK.K ,K.DVNQQEFVR.A ,K.LKVPEWVDTVK.L \n "," "]
["IPI00368250","RGD1561333 similar to 60S ribosomal protein L8",28367,10.79,-0.551,0,"Cytoplasm","rRNA binding,structural constituent of ribosome",157,7,"K.VISSANR.A ,R.KVGLIAAR.R, K.KVISSANR.A, K.DIIHDPGR.S ,R.AVVGVVAGGGR.I ,R.ASGNYATVISHNPETK.K ,\nR.ASGNYATVISHNPETKK.T\n"," "]
["IPI00369774","Mettl7b Methyltransferase-like protein 7B",28342,8.57,-0.078,1,"Endoplasmic reticulum membrane; Peripheral membrane protein; Lipid droplet","Probable methyltransferase ",100,6,"R.HLQYER.F ,K.VLQEVQR.V ,R.KVLQEVQR.V ,R.ETWKDIEK.A  ,K.VTCVDPNPNFEK.F ,K.AQFSEVQLEWQPPPFK.W \n"," "]
["IPI00208175","Tmem33 Transmembrane protein 33",28307,9.72,0.413,3,"Extracellular vesicular exosome (ortholog); melanosome (ortholog)","INTERACTS WITH ammonium chloride; bis(2-ethylhexyl) phthalate; bisphenol A",106,4,"K.GSNSLPLLR.S,K.LSTNQQNILK.F ,R.ALLANALTSALR.L ,R.SVLDKLSTNQQNILK.F \n "," "]
["IPI00371634","Bcap31 B-cell receptor-associated protein 31",27951,8.91,-0.226,3,"Golgi cisterna membrane;clathrin-coated vesicle;endoplasmic reticulum membrane;integral component of plasma membrane;lipid particle","Protein binding",96,6,"R.LLEEHAK.L,K.YDDVTEK.V ,K.QAESASEAAK.K ,R.KYDDVTEK.V ,K.LKDELASTK.K ,K.QAESASEAAKK.Y ,\nK.YMEENDQLKK.G + Oxidation (M) ,K.GTAEDGGKLDVGSPEMK.L + Oxidation (M) \n "," "]
["IPI00367152","Ndufv2 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial",27703,6.23,-0.316,0,"Mitochondrion inner membrane","Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.",51,2,"R.DSDSILETLQR.K,R.AAAVLPVLDLAQR.Q  "," "]
["IPI00558425","Slc25a5 27 kDa protein",27561,9.9,0.028,5,"Membrane","Binding",282,15,"R.TQFWR.Y,R.MMMQSGR.K,R.GNLANVIR.Y,K.TAVAPIER.V,R.GNLANVIR.Y,K.TAVAPIER.V,R.GNLANVIR.Y,K.GLGDCLVK.I,\nR.TRLAADVGK.A,K.QIFLGGVDK.R,K.EQGVLSFWR.G,K.QIFLGGVDKR.T,R.AAYFGIYDTAK.G,K.DFLAGGVAAAISK.T,\nR.YFPTQALNFAFK.D\n"," "]
["IPI00199324","Cisd2 similar to CG1458-PA",27441,9.68,-0.096,1,"Endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); membrane (ortholog)","A protein that exhibits 2 iron, 2 sulfur cluster binding (ortholog); poly(A) RNA binding (ortholog); protein homodimerization activity (ortholog);",105,1,"K.VVNEINIEDLNLTK.A "," "]
["IPI00231767","Tpi1 Triosephosphate isomerase",27345,6.89,-0.1,0,"Cytosol;nucleus","Protein binding,triose-phosphate isomerase activity",85,1,"K.VVLAYEPVWAIGTGK.T"," "]
["IPI00558343","Atp1a1 Na,K-ATPase alpha-1 subunit (Fragment)",27339,6.98,-0.159,0,"Caveola; endoplasmic reticulum; endosome "," Aprotein that exhibits ADP binding; ankyrin binding; ATP binding; ",95,2,"K.TGTLTQNR.M,R.AVAGDASESALLK.C"," "]
["IPI00568876","27 kDa protein",27324,5.5,0.085,0,"Unknown","Unknown",58,3,"K.VFESIGK.F,K.AAIISAEGDSK.A,R.RASDDLTER.A "," "]
["IPI00364707","Tmed9 Transmembrane emp24 protein transport domain containing 9",27182,8.4,-0.302,1,"Endoplasmic reticulum membrane; Single-pass type I membrane protein; Golgi apparatus › cis-Golgi network membrane","Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2.",62,3,"K.LSELQLR.V ,R.QTSESTNQR.V ,K.DKLSELQLR.V "," "]
["IPI00568028","RGD1305679 Isoform 1 of Uncharacterized protein C6orf105 homolog",27057,9.53,0.287,6,"Cell membrane; Multi-pass membrane protein By similarity","Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro).",56,2,"K.WGATVKPR.M,K.LKEFHDGGR.S  "," "]
["IPI00201003","Ebp 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase",26948,7.15,0.503,5,"Endoplasmic reticulum membrane; Multi-pass membrane protein","Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers ",42,2,"R.VSVVPLGTGR.R ,K.HLTNAQSMLDNK.V + Oxidation (M) "," "]
["IPI00212776","Rps3 40S ribosomal protein S3",26828,9.68,-0.153,0,"Cytoplasm","DNA-(apurinic or apyrimidinic site) lyase activity,RNA binding,structural constituent of ribosome",94,7,"R.ACYGVLR.F,R.TQNVLGEK.G ,R.FIMESGAK.G + Oxidation (M) ,K.GCEVVVSGK.L ,K.IMLPWDPSGK.I + Oxidation (M) ,\nR.ELAEDGYSGVEVR.V ,K.DEILPTTPISEQK.G \n "," "]
["IPI00869949","Chchd3 coiled-coil-helix-coiled-coil-helix domain containing 3",26653,8.25,-1.035,0,"Mitochondrial inner membrane;nucleus","RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription.",58,2,"R.LSENVIDR.M,K.AVANEQLTR.A  "," "]
["IPI00230857","Ak2 Isoform 1 of Adenylate kinase 2, mitochondrial",26648,6.33,-0.384,0,"Mitochondrion intermembrane space","Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. ",48,1,"R.AMVASGSELGKK.L + Oxidation (M) "," "]
["IPI00208154","Cd81 CD81 antigen",26555,5.3,0.674,4,"Membrane; Multi-pass membrane protein","May play an important role in the regulation of lymphoma cell growth.",76,3,"R.NSSVY.- ,R.NSLCPSSSNSFTQLLK.E ,K.QFYDQALQQAVMDDDANNAK.A"," "]
["IPI00765773","- 26 kDa protein",26532,5.02,-0.282,0,"Unknown","Unknown",57,1,"K.SDAAVAIAR.L"]
["IPI00372499","Tmem109 Transmembrane protein 109",26282,9.79,0.434,5,"Nucleus outer membrane; Multi-pass membrane protein By similarity; Endoplasmic reticulum membrane","INVOLVED IN cellular response to gamma radiation (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); negative regulation of cell death (ortholog); ",73,2,"R.SSGTHLEAK.V,R.ESSADILTEIGR.S  "," "]
["IPI00358826","RGD1561928 similar to ribosomal protein L9",26253,9.34,-0.218,0,"Ribosome","rRNA binding,structural constituent of ribosome",62,2,"K.FLDGIYVSEK.G,K.TILSNQTVDIPENVDITLKGR.T "," "]
["IPI00209908","Mt-co2 Cytochrome c oxidase subunit 2",26096,4.6,0.269,2,"Mitochondrion inner membrane; Multi-pass membrane protein","Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.",118,6,"K.TDAIPGR.L,R.LLEVDNR.V ,R.VVLPMELPIR.M ,R.LLEVDNRVVLPMELPIR.M ,R.LLEVDNRVVLPMELPIR.M + Oxidation (M) ,\nR.MLISSEDVLHSWAIPSLGLK.T + Oxidation (M) \n "," "]
["IPI00231639","Gstm1 Glutathione S-transferase Mu 1",26068,8.27,-0.518,0,"Cytoplasm","Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. The olfactory GST may be crucial for the acuity of the olfactory process.",88,8,"R.GLTHPIR.L,K.LAQWSNK.- ,K.LYSEFLGK.R ,R.YLSTPIFSK.L,R.KITQSNAIMR.Y ,M.PMILGYWNVR.G ,R.LLLEYTDSSYEEKR.Y ,\nK.LGLDFPNLPYLIDGSR.K \n "," "]
["IPI00231150","Gsta3;Gsta2;Gsta1 Glutathione S-transferase (Fragment)",26029,8.78,-0.324,0,"Cytoplasm","Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has substantial activity toward aflatoxin B1-8,9-epoxide.",101,5,"R.VSNLPTVK.K ,K.FLQPGSQR.K ,R.VSNLPTVKK.F ,R.AILNYIATK.Y ,K.SHGQDYLVGNR.L\n"," "]
["IPI00364616","RGD1309676 Uncharacterized protein C10orf58 homolog",25861,9.19,-0.131,1,"Cytoplasm","Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. ",117,5,"K.NGAVIMAVR.R + Oxidation (M) ,R.LGVWYNSFR.A  ,R.VNLLSVLEAVK.K ,K.AALEYLEDIDLK.T ,K.LDELGVPLYAVVK.E \n"," "]
["IPI00411230","Gstm2 Glutathione S-transferase Mu 2",25857,6.91,-0.502,0,"Cytoplasm","Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. The olfactory GST may be crucial for the acuity of the olfactory process.",44,7,"R.GLAHAIR.L,K.LYSEFLGK.Q,K.ITQSNAILR.Y,R.FLSKPIFAK.M ,R.KKPEYLEGLPEK.M ,K.CLDAFPNLKDFVAR.F ,\nK.LGLDFPNLPYLIDGSHK.I\n "," "]
["IPI00230942","Gstm7 Glutathione S-transferase Yb-3",25835,6.84,-0.399,0,"Cytoplasm","Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.",44,5,"R.GLAHAIR.L,R.LYSEFLGK.R,K.ITQSNAILR.Y,R.LLLEYTDSSYEEKR.Y,K.LGLDFPNLPYLIDGSHK.I,\n"," "]
["IPI00192216","Rab33b RAB33B, member of RAS oncogene family",25753,7.62,-0.232,0,"Golgi lumen","GTP binding",86,1,"K.IQLWDTAGQER.F"]
["IPI00188225","Crp C-reactive protein",25737,4.89,0.1,0,"Secreted ","Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. ",59,1,"R.VFSPNVLNWR.A "]
["IPI00199482","Gstm4 RCG29014, isoform CRA_a",25708,5.65,-0.312,0,"Unknown","Glutathione transferase activity",41,5,"R.GLAHAIR.L,K.ITQSNAILR.Y,K.CLDAFPNLKDFVAR.F,R.LLLEYTDSSYEEKR.Y,K.LGLDFPNLPYLIDGSHK.I \n"," "]
["IPI00231638","Gsta3;Gsta2;Gsta1 Glutathione S-transferase alpha-1",25705,8.87,-0.261,0,"Cytoplasm","Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.",101,5,"R.ISSLPNVK.K,K.FLQPGSQR.K,R.ISSLPNVKK.F,R.AILNYIATK.Y,K.SHGQDYLVGNR.L\n "," "]
["IPI00565741","Cml2 similar to camello-like 2",25675,9.68,0.275,2,"Integral component of membrane ","N-acetyltransferase activity, May play a role in regulation of gastrulation. ",59,2,"R.VLDLFSR.G ,R.LSVSSQHR.G "," "]
["IPI00555178","Gsta2 Glutathione S-transferase alpha-2",25657,8.89,-0.269,0,"Cytoplasm \n"," Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.\n ",85,4,"K.TALAKDR.T,K.FLQPGSQR.K ,R.AILNYIATK.Y ,K.LIQSPEDLEK.L\n "," "]
["IPI00327079","Gstk1 Glutathione S-transferase kappa 1",25590,9.13,-0.116,0," Mitochondrion matrix\n ","Might confer protection against genotoxic and cytotoxic electrophiles in the mitochondrial compartment.\n",99,2,"K.YGAFGLPTTVAHVDGK.T ,R.IWSRDEDITESQNILSAAEK.A "," "]
["IPI00211897","Gsta3;Gsta2;Gsta1 Glutathione S-transferase alpha-5",25388,8.42,-0.364,0,"Cytoplasm","Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has substantial activity toward aflatoxin B1-8,9-epoxide. ",79,5,"R.VSNLPTVK.K,K.FLQPGSQR.K,R.VSNLPTVKK.F,K.AILNYIATK.Y,M.PGKPVLHYFDGR.G\n"," "]
["IPI00231659","Tmed10 Transmembrane emp24 domain-containing protein 10",25013,6,-0.127,2,"Golgi apparatus; cis-Golgi network membrane; Single-pass type I membrane protein; Melanosome (By similarity); Endoplasmic reticulum membrane","Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus. ",93,7,"K.NYEEIAK.V ,R.DTNESTNTR.V ,K.LKPLEVELR.R ,K.NYEEIAKVEK.L ,R.IPDQLVILDMK.H ,K.ITDSAGHILYAK.E ,\nR.IPDQLVILDMK.H + Oxidation (M) \n"," "]
["IPI00339012","Rpl10a 60S ribosomal protein L10a",24987,9.94,-0.408,0,"Cytosolic large ribosomal subunit","RNA binding,structural constituent of ribosome",89,4,"K.STMGKPQR.L,R.EVLHGNQR.K ,R.DTLYEAVR.E ,K.KYDAFLASESLIK.Q \n "," "]
["IPI00203760","Rab39 RAB39, member RAS oncogene family",24912,8.13,-0.314,0,"Phagocytic vesicle","GTP binding",86,1,"K.LQLWDTAGQER.F"]
["IPI00193522","Sec22b Vesicle-trafficking protein SEC22b",24896,8.67,-0.182,1,"Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type IV membrane protein;Golgi apparatus membrane","SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. ",90,4,"M.VLLTMIAR.V,K.ANNLSSLSK.K ,K.LNEQSPTR.C ,R.NLGSINTELQDVQR.I \n "," "]
["IPI00569843","25 kDa protein",24825,11.44,-0.879,0,"Unknown","Unknown",64,3,"K.LILFPR.K,K.EAAEQDVEK.K,R.VDTWFNQPAR.K"," "]
["IPI00196795","Rab15 Ras-related protein Rab-15",24610,5.36,-0.534,0,"Cell membrane; Lipid-anchor; Cytoplasmic side (Potential) ","May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.",129,2,"R.LLLIGDSGVGK.T,R.IQIWDTAGQER.Y"," "]
["IPI00781252","24 kDa protein",24595,9.39,-0.524,0,"Ribosome","Structural constituent of ribosome",47,1,"K.MLSCAGADR.L + Oxidation (M) "," "]
["IPI00210381","Rab11b Ras-related protein Rab-11B",24588,5.64,-0.435,0,"Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)","GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis. ",95,3,"K.VVLIGDSGVGK.S,K.HLTYENVER.W , K.AQIWDTAGQER.Y"," "]
["IPI00231202","Rps8 40S ribosomal protein S8",24475,10.32,-1.02,0,"Cytoplasm (By similarity)","A protein that exhibits poly(A) RNA binding (ortholog); ",356,8,"R.ADGYVLEGK.E,K.LTPEEEEILNK.K ,R.KYELGRPAANTK.I ,K.NCIVLIDSTPYR.Q ,K.ISSLLEEQFQQGK.L ,K.LLACIASRPGQCGR.A ,\nR.QWYESHYALPLGR.K ,R.IIDVVYNASNNELVR.T \n "," "]
["IPI00230916","Rpl13 60S ribosomal protein L13",24351,11.54,-0.894,0,"Cytosolic large ribosomal subunit;large ribosomal subunit","Structural constituent of ribosome",126,7,"K.LILFPR.K,R.GFSLEELR.V ,K.EAAEQDVEK.K ,R.AITEEEKNFK.A ,K.STESLQANVQR.L ,R.VDTWFNQPAR.K ,R.NKSTESLQANVQR.L \n "," "]
["IPI00231445","Rpl15 60S ribosomal protein L15",24245,11.62,-0.93,0,"Cytosolic large ribosomal subunit","Structural constituent of ribosome",69,4,"R.GLTSAGRK.S,R.NTLQLHR.Y ,K.YIQELWR.K ,R.SLQSVAEER.A \n "," "]
["IPI00372393","Krtcap2 Keratinocyte-associated protein 2",24212,9.84,0.419,3,"Membrane; Multi-pass membrane protein (Potential)","INTERACTS WITH clofibric acid; N-nitrosodiethylamine; 17alpha-ethynylestradiol (ortholog)",53,1,"K.ISSTLYQATAPALTPAK.V "," "]
["IPI00476506","24 kDa protein",24168,11.36,-0.835,0,"Unknown","Unknown",120,5,"R.GFSLEELR.V,R.TIGISVDPR.R ,R.AKEAAEQDVEK.K ,K.STESLQANVQR.L ,K.LATQLTGPVMPIR.N\n "," "]
["IPI00363792","24 kDa protein",24135,10.36,-0.881,0,"Unknown","Unknown",107,2,"R.ADGYVLEGK.E,K.ISSLLEEQFQQGK.L"," "]
["IPI00558685","24 kDa protein",24113,5.55,-0.036,0,"Unknown","Unknown",59,2,"K.VFESIGK.F,K.QVAQQEAER.A"," "]
["IPI00390829","RGD1563145 similar to 60S ribosomal protein L13",24078,11.47,-0.842,0,"Cytosolic large ribosomal subunit;large ribosomal subunit","Structural constituent of ribosome",104,6,"K.LILFPR.K,R.GFSLEELR.V,K.EAAEQDVEK.K,R.AITEEEKNFK.A,K.STESLQANVQR.L,R.NKSTESLQANVQR.L\n"," "]
["IPI00189554","Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase",23939,8.56,0.604,3,"Endoplasmic reticulum membrane; Multi-pass membrane protein; Golgi apparatus membrane","Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. ",57,2,"K.MIDLSGNPVLR.I,K.SIISVIHLVTAAR.N  "," "]
["IPI00196794","Rab14 Ras-related protein Rab-14",23927,5.85,-0.411,0,"Recycling endosome; Early endosome membrane; Lipid-anchor; Golgi apparatus membrane","Regulates, together with its guanine nucleotide exchange factor, DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion. Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes.",86,1,"K.LQIWDTAGQER.F"]
["IPI00475722","Rpl14 Rpl14 protein",23879,11.12,-0.51,0,"Ribosome","Structural constituent of ribosome",76,4,"K.AAIAAAAAAK.A,R.ALVDGPCTR.V ,R.VAYISFGPHAGK.L ,K.CMQLTDFILK.F \n "," "]
["IPI00194388","Sdf2l1 stromal cell-derived factor 2-like 1",23872,6.92,-0.353,0,"Endoplasmic reticulum; membrane ","A protein that exhibits ATPase binding; chaperone binding; misfolded protein binding;",70,1,"K.YGSGSGQQSVTGVEASDDANSYWR.I "," "]
["IPI00213644","Ppib Peptidyl-prolyl cis-trans isomerase B",23845,9.5,-0.202,1,"Endoplasmic reticulum lumen (By similarity); Melanosome ","PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. ",355,10,"R.VTFGLFGK.T ,K.VLEGMDVVR.K ,K.VLEGMDVVR.K + Oxidation (M) ,.TVDNFVALATGEK.G ,K.IEVEKPFAIAKE.- ,\nK.DTNGSQFFITTVK.T ,K.TSWLDGKHVVFGK.V ,K.HYGPGWVSMANAGK.D + Oxidation (M) ,R.DKPLKDVIIVDCGK.I, \nR.VIKDFMIQGGDFTR.G + Oxidation (M) \n"," "]
["IPI00782551","24 kDa protein",23791,9.81,-0.134,0,"Unknown","Unknown",186,5,"K.DLQNVNITLR.I,R.VLPSITTEILK.S,R.ILFRPVASQLPR.I,R.IYTSIGEDYDER.V,R.IYTSIGEDYDERVLPSITTEILK.S\n"," "]
["IPI00215564","Rab7a Ras-related protein Rab-7a",23774,6.4,-0.377,0,"Late endosome; Lysosome; Cytoplasmic vesicle; phagosome (By similarity); Melanosome (By similarity)","Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. ",63,6,"K.IDLENR.Q,K.FSNQYK.A ,K.NNIPYFETSAK.E ,R.DPENFPFVVLGNK.I ,K.EAINVEQAFQTIAR.N ,K.TLDSWRDEFLIQASPR.D \n "," "]
["IPI00191761","Rab5c Rab5c protein",23639,8.64,-0.309,0,"Endocytic vesicle;lipid particle;lysosomal membrane","GDP binding,GTP binding",74,1,"R.GVDLQESNPASR.S "]
["IPI00189690","Rab8b Ras-related protein Rab-8B",23603,9.15,-0.372,0,"Cell membrane; Lipid-anchor; Cytoplasmic side Potential; Cytoplasmic vesicle › phagosome membrane; Lipid-anchor; Cytoplasmic side ","The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells.",129,2,"K.LLLIGDSGVGK.T,K.LQIWDTAGQER.F"," "]
["IPI00559336","LOC688815 similar to prohibitin",23579,6.76,0.048,0,"Mitochondrion inner membrane\n","Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.\n",235,7,"K.VFESIGK.F,R.FDAGELITQR.E,K.DLQNVNITLR.I,R.VLPSITTEILK.S,R.ILFRPVASQLPR.I,R.IYTSIGEDYDER.V,\nR.IYTSIGEDYDERVLPSITTEILK.S\n"," "]
["IPI00655314","Rpl13a 60S ribosomal protein L13a",23575,11.02,-0.443,0,"GAIT complex;large ribosomal subunit;ribosome","Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. ",61,9,"K.FAYLGR.L,K.FTEVLK.T ,R.GQAALER.L ,R.GPYHFR.A ,R.MNTNPSR.G ,R.MVVPAALK.V ,R.MVVPAALK.V + Oxidation (M) ,\nK.RGQAALER.L ,K.YQAVTATLEEK.R \n "," "]
["IPI00202214","Rpl19 60S ribosomal protein L19",23565,11.48,-1.111,0,"Ribosome","Structural constituent of ribosome",178,5,"R.LASSVLR.C,R.KPVTVHSR.A ,K.LLADQAEAR.R ,K.TLSKEEETK.K ,K.VWLDPNETNEIANANSR.Q\n "," "]
["IPI00876581","Rbp4 Retinol-binding protein 4",23547,5.69,-0.515,0,"Secreted","Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli. ",78,1,"R.FSGLWYAIAK.K "]
["IPI00373197","Pgrmc2 Membrane-associated progesterone receptor component 2",23503,5.11,-0.459,1,"Membrane; Single-pass membrane protein (Potential) ","Receptor for steroids (Potential). ",140,4,"K.VFDVTK.G,R.GLATFCLDK.D,R.GGDGSPGGAGATAAR.S ,K.FYGPAGPYGIFAGR.D \n"," "]
["IPI00365960","Reep6 Receptor expression-enhancing protein 6",23469,8.39,0.278,3,"Membrane; Multi-pass membrane protein (By similarity);Cytoplasm","May enhance the cell surface expression of odorant receptors. ",105,1,"K.NVATDALGALEAR.T "," "]
["IPI00195123","Atp5o ATP synthase subunit O, mitochondrial",23440,10.03,-0.022,0,"Mitochondrion (By similarity); Mitochondrion inner membrane ","Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. ",369,12,"K.YVDMSAK.S ,K.YVDMSAK.S + Oxidation (M) ,K.SLKDITTK.E ,R.VGQLLKDPK.V ,K.TVLNSFLSK.G ,K.GQILNLEVK.T ,\nR.YATALYSAASK.Q ,K.VSLAVLNPYIK.R ,R.LDQVEKELLR.V ,K.LVRPPVQVYGIEGR.Y ,K.FSPLTANLMNLLAENGR.L ,\nR.LGNTQGVISAFSTIMSVHR.G \n"," "]
["IPI00371187","Rab35 Ras-related protein Rab-35",23296,8.53,-0.473,0,"Cell membrane; Lipid-anchor; Cytoplasmic side (Potential); Membrane;clathrin-coated pit (By similarity); Cytoplasmic vesicle; clathrin-coated vesicle (By similarity); Endosome (By similarity);Melanosome ","In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, Endosome (By similarity). Melanosome (By similarity). namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. ",129,2,"K.LLIIGDSGVGK.S,K.LQIWDTAGQER.F"," "]
["IPI00196790","Rab10 Ras-related protein Rab-10",23072,9.1,-0.402,0,"Cytoplasmic vesicle membrane (By similarity); Lipid-anchor (Probable); Cytoplasmic side (Probable); Golgi apparatus, trans-Golgi network membrane (By similarity); Endosome membrane (By similarity);Recycling endosome membrane (By similarity); Cytoplasmic vesicle; phagosome membrane (By similarity); Cell projection, cilium","The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the basolateral membrane. Moreover, it may play a role in the basolateral recycling pathway. Finally, it may also play a role in phagosome maturation. ",129,3,"K.GKGEQIAR.E,K.LLLIGDSGVGK.T,K.LQIWDTAGQER.F"," "]
["IPI00886474","Rps5 Rps5 protein",23063,9.73,-0.393,0,"Cytosolic small ribosomal subunit","mRNA binding,structural constituent of ribosome",298,5,"K.YLPHSAGR.Y ,K.GSSNSYAIK.K ,K.AQCPIVER.L ,R.VNQAIWLLCTGAR.E ,K.TIAECLADELINAAK.G \n"," "]
["IPI00210964","Rps5 40S ribosomal protein S5",23035,9.68,-0.401,0,"Cytosolic small ribosomal subunit","RNA binding,structural constituent of ribosome",70,2,"K.YLPHSAGR.Y,R.VNQAIWLLCTGAR.E  "," "]
["IPI00210008","Tmed2 Transmembrane emp24 domain-containing protein 2",22832,5.08,0.019,2,"COPI-coated vesicle; integral component of membrane; zymogen granule membrane","INVOLVED IN embryonic placenta development (ortholog); Golgi organization (ortholog); heart looping (ortholog); INTERACTS WITH 2-ethoxyethanol; 2-methoxyethanol; 5-methoxy-2-\\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\\}-1H-benzimidazole",58,2," R.MSTMTPK.I + Oxidation (M) ,R.AINDNTNSR.V \n"," "]
["IPI00555185","Rab10 RAB10, member RAS oncogene family",22755,8.58,-0.33,0,"Golgi apparatus;endoplasmic reticulum membrane;endoplasmic reticulum tubular network;insulin-responsive compartment;\nplasma membrane;primary cilium;recycling endosome","GDP binding,GTP binding,GTPase activity",197,5,"K.GKGEQIAR.E ,K.LLLIGDSGVGK.T ,K.AFLTLAEDILR.K ,K.LQIWDTAGQER.F ,R.NIDEHANEDVER.M \n"," "]
["IPI00188359","Abhd14b Abhydrolase domain-containing protein 14B",22718,5.65,0.082,0,"Cytoplasm (By similarity); Nucleus (By similarity)","Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription. ",50,1,"R.AVAIDLPGLGR.S "]
["IPI00421626","Rps9 40S ribosomal protein S9",22635,10.66,-0.644,0,"Cytoplasm (By similarity)","A protein that exhibits rRNA binding (inferred); structural constituent of ribosome (inferred); ",198,6,"K.LIGEYGLR.N,R.SPYGGGRPGR.V ,R.RLQTQVFK.L ,R.LFEGNALLR.R ,K.QVVNIPSFIVR.L ,K.KGQGGAGAGDDEEED.- \n "," "]
["IPI00373755","RGD1564883 similar to 60S ribosomal protein L12",22630,10.22,-0.455,0,"Ribosome","Binds directly to 26S ribosomal RNA",86,3,"K.LTIQNR.Q,K.KVGDDIAK.A,K.IGPLGLSPK.K"," "]
["IPI00198310","Fkbp11 FK506 binding protein 11",22342,9.32,0.017,1,"Membrane","FK506 binding,peptidyl-prolyl cis-trans isomerase activity",67,1,"R.IIDTSLTRDPLVIELGQK.Q "," "]
["IPI00211779","Prdx1 Peroxiredoxin-1",22323,8.27,-0.222,0,"Cytoplasm;Melanosome ","Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. ",51,3,"K.ADEGISFR.G,R.TIAQDYGVLK.A , R.QITINDLPVGR.S"," "]
["IPI00421451","Rps16 similar to 40S ribosomal protein S16",22231,10.21,-0.445,0,"Cytosolic small ribosomal subunit;small ribosomal subunit","RNA binding,structural constituent of ribosome",84,6,"R.TLLVADPR.R,K.YVDEASKK.E ,K.TATAVAHCK.R ,K.LLEPVLLLGK.E ,K.LLEPVLLLGKER.F ,K.EIKDILIQYDR.T \n "," "]
["IPI00214582","LOC497813;Rps7 40S ribosomal protein S7",22113,10.09,-0.459,0,"Cytoplasm;cytoskeleton;centrosome (By similarity)","Required for rRNA maturation ",129,5,"R.ILPKPTR.K,K.HVVFIAQR.R ,K.VETFSGVYK.K ,K.AIIIFVPVPQLK.S ,K.LTGKDVNFEFPEFQL.- \n "," "]
["IPI00189880","22 kDa protein",22110,10.09,-0.316,0,"Ribosome ","rRNA binding; structural constituent of ribosome",65,1,"K.FLDGIYVSEK.G "]
["IPI00230917","Rpl18 60S ribosomal protein L18",21702,11.79,-0.718,0,"Ribosome","Structural constituent of ribosome",169,7,"K.SQDIYLR.L,R.GTVLLSGPR.K ,R.TNRPPLSLSR.M ,R.TNSTFNQVVLK.R ,K.TAVVVGTITDDVR.I ,R.TNSTFNQVVLKR.L ,\nK.ILTFDQLALESPK.G \n "," "]
["IPI00480820","Pgrmc1 Membrane-associated progesterone receptor component 1",21699,4.43,-0.598,1,"Microsome membrane; Single-pass membrane protein, Endoplasmic reticulum membrane; Single-pass membrane protein","Receptor for progesterone, May be implicated in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) immunotoxicity.\n",727,13,"K.VFDVTK.G,R.ILMAINGK.V ,R.ILMAINGK.V + Oxidation (M) ,R.DFTPAELR.R ,R.YDGVQDPR.I ,R.GLATFCLDK.E , R.DFTPAELRR.Y ,R.RYDGVQDPR.I ,K.FYGPEGPYGVFAGR.D ,R.KFYGPEGPYGVFAGR.D ,R.GDQPGASGDNDDDEPPPLPR.L ,\nK.EGEEPTVYSDDEEPKDEAAR.K ,K.IVRGDQPGASGDNDDDEPPPLPR.L \n "," "]
["IPI00210946","Rpl17 60S ribosomal protein L17",21611,10.2,-0.903,0,"Large ribosomal subunit;ribosome","Structural constituent of ribosome",82,4,"R.ETAQAIK.G,K.QCVPFR.R,K.NAESNAELK.G ,R.YSLDPENPTK.S \n "," "]
["IPI00766280","LOC680782 similar to signal peptidase complex subunit 3 homolog",21388,8.66,0.134,1,"Endoplasmic reticulum (ortholog) ","A protein that exhibits peptidase activity (inferred); ",52,1,"K.NVEDFTGPR.E"]
["IPI00187747","Rap1a Ras-related protein Rap-1A",21316,6.39,-0.375,0,"Cell membrane; Lipid-anchor ","Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. ",58,2,"R.VVGKEQGQNLAR.Q,K.INVNEIFYDLVR.Q  "," "]
["IPI00202238","Ndufb10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10",21131,7.57,-0.937,0,"Extracellular vesicular exosome (ortholog); mitochondrial inner membrane (ortholog); mitochondrial respiratory chain complex I (ortholog)","PARTICIPATES IN Alzheimer disease pathway; Huntington disease pathway; oxidative phosphorylation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; dibutyl phthalate; benzo[a]pyrene (ortholog);",113,5,"R.EGESALQNCAK.E ,K.ELEQFTQVSK.A ,R.YQDLGAYYSAR.K ,K.AYQDRYQDLGAYYSAR.K ,R.TPAPSPQTSIPNPITYLTK.A \n"," "]
["IPI00554102","LOC259246;LOC685482 similar to alpha2u globulin",21084,5.62,-0.293,0,"Cytoplasm › cytosol; Secreted \n","Major urinary proteins (Mups) bind and release pheromones. They may also protect pheromones from oxidation. In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup-suckling, territory establishment and dominance. Acts as a kairomone, detected by the prey vomeronasal organ and inducing fear reactions in mice.\n",54,3,"R.DNIIDLTK.T,K.LCEAHGITR.D,K.LNGDWFSIVVASDKR.E"," "]
["IPI00196589","Ssr3 Translocon-associated protein subunit gamma",21051,9.61,0.066,4,"Endoplasmic reticulum membrane; Multi-pass membrane protein ","TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.",100,5,"K.LSEADNR.K ,R.KLSEADNR.K ,K.LSEADNRK.M ,R.EDAVSKEVTR.K ,K.QQSEEDLLLQDFSR.N \n"," "]
["IPI00191711","LOC259246 Major urinary protein",21009,5.85,-0.248,0,"Cytoplasm; cytosol","Major urinary proteins (Mups) bind and release pheromones. They may also protect pheromones from oxidation. In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup-suckling, territory establishment and dominance. Acts as a kairomone, detected by the prey vomeronasal organ and inducing fear reactions in mice. ",66,5,"R.GNLDVAK.L,R.DNIIDLTK.T ,K.LCEAHGITR.D,R.VFMQHIDVLENSLGFK.F ,R.VFMQHIDVLENSLGFK.F + Oxidation (M) \n "," "]
["IPI00464895","LOC298116 Rat alpha-2u-globulin",21007,5.41,-0.269,0,"Extracellular region","Pheromone binding,small molecule binding,transporter activity",54,5,"R.DNIIDLTK.T,K.LCEAHGITR.D,K.LNGDWFSIVVASDKR.E ,R.VFMQHIDVLENSLGFK.F,R.VFMQHIDVLENSLGFK.F + Oxidation (M)\n"," "]
["IPI00359103","Rpl11 60S ribosomal protein L11",20468,9.64,-0.534,0,"Nucleus; nucleolus ","Required for rRNA maturation and formation of the 60S ribosomal subunits (By similarity). Binds to 5S ribosomal RNA. Promotes nucleolar location of PML. ",229,4,"R.TGCIGAK.H ,K.YDGIILPGK.- ,R.GAKAEEILEK.G ,K.VLEQLTGQTPVFSK.A \n"," "]
["IPI00209886","RGD1311378 Similar to RIKEN cDNA 2010011I20 (Predicted), isoform CRA_a",20258,10.69,0.345,0,"Unknown","INTERACTS WITH dibutyl phthalate; fipronil; thioacetamide",60,1,"R.TTDPGSGATSTEK.K "," "]
["IPI00421625","Mrlc2 Myosin regulatory light chain 12B",19883,4.76,-0.795,0,"Z disc;apical part of cell;myosin II complex;protein complex;stress fiber","Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. ",79,1,"K.GNFNYIEFTR.I "]
["IPI00194222","Cox4i1 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial",19559,9.45,-0.37,1,"Mitochondrion inner membrane","This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. ",69,4,"K.LLSASQK.A,K.VNPIQGFSAK.W ,R.DYPLPDVAHVK.L ,K.SEDYALPSYVDRR.D\n "," "]
["IPI00198900","Mal2 MAL2 proteolipid protein",19468,6,0.833,4,"Extracellular vesicular exosome (ortholog); membrane raft (ortholog)","INTERACTS WITH diuron; fipronil; genistein",48,1,"R.ITLPAGPDILR.T "]
["IPI00201932","Ssr4 Translocon-associated protein subunit delta",19323,5.77,0.153,1,"Endoplasmic reticulum membrane; Single-pass type I membrane protein\n","TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.\n",193,4,"K.SAHAGTYEVR.F,R.YQVSWSLEHK.S ,R.FFDEESYSLLR.K ,K.NRVQNMALYADVSGK.Q + Oxidation (M)\n "," "]
["IPI00361431","RGD1564698 similar to ribosomal protein S10",18881,10.64,-0.651,0,"Unknown","INTERACTS WITH cadmium dichloride (ortholog); cobalt dichloride (ortholog); cocaine (ortholog)",87,3,"K.GPEGERPAR.F ,R.IAIYELLFK.E ,R.DYLHLPPEIVPATLR.R"," "]
["IPI00369350","Skp1 S-phase kinase-associated protein 1",18831,4.4,-0.716,0,"Cul7-RING ubiquitin ligase complex;SCF ubiquitin ligase complex;cytosol","Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) direct ubiquitination of TTI1 and TELO2 By similarity. SCF(FBXO10) direct ubiquitination of BCL2 By similarity.\n",49,1,"K.TPEEIR.K"]
["IPI00230838","Atp5h ATP synthase subunit d, mitochondrial",18809,6.16,-0.702,0,"Mitochondrion; Mitochondrion inner membrane. ","Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. ",93,6,"R.VREYEK.Q,K.SWNETFHTR.L ,R.ANVDKPGLVDDFK.N ,R.KYPYWPHQPIENL.- ,R.LASLSEKPPAIDWAYYR.A ,\nK.IKNMIPFDQMTIDDLNEVFPETK.L + 2 Oxidation (M) \n "," "]
["IPI00369443","RGD1562469 similar to ribosomal protein L21",18617,10.4,-0.899,0,"Ribosome","Structural constituent of ribosome",91,2,"R.DSFLKR.V,R.VYNVTQHAVGIIVNK.Q  "," "]
["IPI00197713","Rps11 40S ribosomal protein S11",18590,10.31,-0.607,0,"Cytosolic small ribosomal subunit;membrane","rRNA binding,structural constituent of ribosome",68,4,"R.VLLGETGKEK.L,K.CPFTGNVSIR.G ,K.EAIEGTYIDKK.C ,R.DVQIGDIVTVGECRPLSK.T  \n "," "]
["IPI00371518","Sdhc Succinate dehydrogenase complex, subunit C, integral membrane protein",18419,10.24,0.547,3,"Mitochondrion;succinate dehydrogenase complex","Electron carrier activity,succinate dehydrogenase activity",40,1,"K.NTSSNRPVSPHLTIYR.W "," "]
["IPI00359900","Vkorc1 Vitamin K epoxide reductase complex subunit 1",18171,9.5,0.629,3,"Endoplasmic reticulum membrane; Multi-pass membrane protein","Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development. ",91,1,"R.ALCDVGTAISCSR.V "," "]
["IPI00210164","Rpl12 similar to 60S ribosomal protein L12",18007,9.35,-0.401,0,"Ribosome","Binds directly to 26S ribosomal RNA.",138,4,"K.LTIQNR.Q,K.KVGDDIAK.A ,K.IGPLGLSPK.K ,R.QAQIEVVPSASALIIK.A \n "," "]
["IPI00230939","Rpl24 60S ribosomal protein L24",17882,11.26,-0.926,0,"Cytosolic large ribosomal subunit","Structural constituent of ribosome",106,5,"R.NQKPEVR.K,K.GQSEEIQK.K ,R.QINWTVLYR.R ,R.AITGASLADIMAK.R ,R.TDGKVFQFLNAK.C \n "," "]
["IPI00563665","similar to ribosomal protein L31",17869,9.93,-0.708,0,"Ribosome","Structural constituent of ribosome",58,2,"M.SPDCR.K ,K.LYTLVTYVPVTTFK.N "," "]
["IPI00188058","Rps18 40S ribosomal protein S18",17708,10.99,-0.71,0,"Cytoplasm","Located at the top of the head of the 40S subunit, it contacts several helices of the 18S Rrna. ",128,5,"R.YAHVVLR.K ,K.IAFAITAIK.G ,R.VLNTNIDGR.R ,K.IPDWFLNR.Q , R.AGELTEDEVER.V \n"," "]
["IPI00203523","Rpl23a 60S ribosomal protein L23a",17684,10.44,-0.726,0,"Nucleus;ribosome","This protein binds to a specific region on the 26S rRNA. ",47,2,"K.VNTLIRPDGEK.K,R.LAPDYDALDVANK.I  "," "]
["IPI00214217","RGD1562404 similar to ribosomal protein S18",17660,10.33,-0.666,0,"Ribosome","RNA binding,structural constituent of ribosome",112,4,"R.YAHVVLR.K,K.IAFAITAIK.G,R.VLNTNIDGR.W,R.AGELTEDEVER.V\n"," "]
["IPI00198620","Atp5d ATP synthase subunit delta, mitochondrial",17584,5.11,0.197,0,"Mitochondrion; Mitochondrion inner membrane","Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. ",140,3,"R.AEIQIR.I,R.IEANEALVK.A , K.AQSELSGAADEAAR.A "," "]
["IPI00230889","Mgst1 Microsomal glutathione S-transferase 1",17517,9.62,0.193,2,"Microsome; Mitochondrion outer membrane; Peripheral membrane protein;Endoplasmic reticulum membrane; Multi-pass membrane protein. ","Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. ",733,8,"R.TDEKVER.V,K.MMFLSSATAFQR.L ,K.MMFLSSATAFQR.L + Oxidation (M) ,K.VFANPEDCAGFGK.G ,\nK.MMFLSSATAFQR.L + 2 Oxidation (M) ,R.LTNKVFANPEDCAGFGK.G ,R.IYHTIAYLTPLPQPNR.G ,K.VFANPEDCAGFGKGENAK.K \n "," "]
["IPI00200552","Rpl26 60S ribosomal protein L26",17267,10.63,-1.116,0,"Large ribosomal subunit","Structural constituent of ribosome",43,1,"K.DDEVQVVR.G "]
["IPI00366014","Rps13;LOC684988 40S ribosomal protein S13",17212,10.53,-0.454,0,"Cytosolic small ribosomal subunit","Structural constituent of ribosome",111,6,"R.LILIESR.I,R.DSHGVAQVR.F ,K.YESSTASALVA.- ,K.GLTPSQIGVILR.D ,K.KGLTPSQIGVILR.D ,K.LTSDDVKEQIYK.L \n "," "]
["IPI00195706","17 kDa protein",17186,11.32,-0.699,0,"Ribosome ","Structural constituent of ribosome ",68,2,"R.IAGQVAAANK.K"]
["IPI00365944","Myl6l Myosin light polypeptide 6",17135,4.46,-0.406,0,"Myosin complex;unconventional myosin complex","Regulatory light chain of myosin. Does not bind calcium.",59,2,"R.ALGQNPTNAEVLK.V ,K.NKDQGTYEDYVEGLR.V "," "]
["IPI00371036","Fis1 Mitochondrial fission 1 protein",17041,8.55,-0.286,1,"Mitochondrion outer membrane; Single-pass membrane protein;Peroxisome membrane","Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.",44,1,"R.GIVLLEELLPK.G "]
["IPI00204128","RGD1561381 similar to microsomal glutathione S-transferase 3",16924,9.4,0.247,4,"Membrane","Transferase activity",66,2,"R.IASGLGVAWIIGR.V,R.VLYAYGYYTGDPSKR.Y  "," "]
["IPI00373430","Ostc Oligosaccharyltransferase complex subunit OSTC",16918,9.23,0.633,3,"Oligosaccharyltransferase complex (ortholog) ","INTERACTS WITH 2-methoxyethanol; 5-methoxy-2-\\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\\}-1H-benzimidazole; 6-propyl-2-thiouracil",105,1,"R.VPFLVLECPNLK.L "]
["IPI00780783","17 kDa protein",16677,9.2,-0.009,0,"Unknown","Unknown",40,1,"R.LGVWYNSFR.A"]
["IPI00201500","Rps14 40S ribosomal protein S14",16420,10.07,-0.503,0,"Cytosolic small ribosomal subunit","RNA binding,structural constituent of ribosome",135,5,"K.TPGPGAQSALR.A,R.TKTPGPGAQSALR.A ,R.IEDVTPIPSDSTR.R ,R.IEDVTPIPSDSTRR.K ,K.IGRIEDVTPIPSDSTR.R\n "," "]
["IPI00210868","16 kDa protein",16387,9.67,-0.536,0,"Ribosome","Structural constituent of ribosome",53,4,"K.LQEEER.E ,K.LQEEERER.R ,R.LGNDFHTNKR.V ,R.VCEEIAIIPSK.N \n"," "]
["IPI00362291","16 kDa protein",16376,5.57,-0.208,0,"Unknown","Unknown",98,4,"K.IIDAALR.A,R.ILEVVKDK.A,R.LNDFASAVR.I,R.RLNDFASAVR.I\n"," "]
["IPI00192246","Cox5a Cytochrome c oxidase subunit 5A, mitochondrial",16347,6.08,-0.142,0,"Mitochondrion inner membrane","This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.",134,6,"K.IIDAALR.A,R.ILEVVKDK.A ,R.LNDFASAVR.I ,R.RLNDFASAVR.I ,K.GMNTLVGYDLVPEPK.I ,R.WVTYFNKPDIDAWELRK.G \n "," "]
["IPI00193233","Cyb5b Cytochrome b5 type B",16312,4.92,-0.626,1,"Mitochondrion outer membrane","Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. ",64,4,"R.LEEVAKR.N,R.NGQGSDPAVTYYR.L ,R.NTAEETWMVIHGR.V ,K.QYYIGDVHPNDLKPK.D\n "," "]
["IPI00198880","Rab26 16 kDa protein",16216,10.11,-0.416,0,"Intrinsic component of plasma membrane; Golgi membrane (ortholog); secretory granule membrane (ortholog)","A protein that exhibits GTP binding; GMP binding (ortholog);",86,1,"K.LQIWDTAGQER.F"]
["IPI00212478","Hbe1 RCG39817, isoform CRA_a",16151,7.9,0.056,0,"Hemoglobin complex","Heme binding,hemoglobin alpha binding,iron ion binding,oxygen binding,oxygen transporter activity",77,1,"R.LLVVYPWTQR.F"]
["IPI00231192","LOC100134871;LOC689064;MGC72973 Hemoglobin subunit beta-2",16086,8.91,-0.003,0,"Hemoglobin complex","Involved in oxygen transport from the lung to the various peripheral tissues. ",115,5,"M.VHLTDAEK.A,K.VINAFNDGLK.H,R.LLVVYPWTQR.Y,K.VVAGVASALAHKYH.-,K.FGDLSSASAIMGNPQVK.A \n"," "]
["IPI00567617","RGD1562153 similar to 40S ribosomal protein S19",16084,10.44,-0.645,0,"Cytosolic small ribosomal subunit;nucleolus","Required for pre-rRNA processing and maturation of 40S ribosomal subunits. ",68,3,"K.LTPQGQR.D,R.KLTPQGQR.D ,R.IAGQVAAANK.K  "," "]
["IPI00230897","Hbb Hemoglobin subunit beta-1",16083,7.87,-0.042,0,"Hemoglobin complex","Involved in oxygen transport from the lung to the various peripheral tissues. ",414,7,"M.VHLTDAEK.A ,K.VINAFNDGLK.H,R.LLVVYPWTQR.Y ,K.VNPDDVGGEALGR.L ,K.VVAGVASALAHKYH.- ,\nR.YFDSFGDLSSASAIMGNPK.V ,R.YFDSFGDLSSASAIMGNPK.V + Oxidation (M) \n"," "]
["IPI00231643","Sod1 Superoxide dismutase [Cu-Zn]",16073,5.88,-0.404,0,"Cytoplasm","Destroys radicals which are normally produced within the cells and which are toxic to biological systems. ",159,5,"K.HGGPADEER.H ,R.LACGVIGIAQ.- ,K.KHGGPADEER.H ,R.HVGDLGNVAAGK.D ,K.DGVANVSIEDR.V \n"," "]
["IPI00210238","Rps23 40S ribosomal protein S23",15969,10.5,-0.519,0,"Ribosome;small ribosomal subunit","Structural constituent of ribosome,translation regulator activity",87,3,"K.QPNSAIRK.C,K.VANVSLLALYK.G , R.KGHAVGDIPGVR.F"," "]
["IPI00324380","Ttr Transthyretin",15824,5.77,0.001,0,"Secreted","Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. ",92,2,"R.GSPAVDVAVK.V,K.TADGSWEPFASGK.T "," "]
["IPI00188985","LOC688784 similar to ribosomal protein L27",15732,10.42,-0.611,0,"Ribosome","Structural constituent of ribosome",41,1,"R.YSVDIPLDK.T "]
["IPI00287835","Hba-a2 Hemoglobin subunit alpha-1/2",15490,7.81,-0.115,0,"Hemoglobin complex","Involved in oxygen transport from the lung to the various peripheral tissues. ",204,6,"K.KVADALAK.A ,R.VDPVNFK.F ,R.MFAAFPTTK.T ,M.VLSADDKTNIK.N ,K.IGGHGGEYGEEALQR.M ,K.TYFSHIDVSPGSAQVK.A \n"," "]
["IPI00214654","Rps24 Isoform 1 of 40S ribosomal protein S24",15413,10.79,-0.995,0,"Cytosolic small ribosomal subunit;nucleolus;ribosome;small ribosomal subunit","Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. ",47,1,"K.TTGFGMIYDSLDYAK.K "," "]
["IPI00286154","Cyb5a Isoform Long of Cytochrome b5",15346,4.87,-0.579,1,"Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side; Microsome membrane","Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. It is also involved in several steps of the sterol biosynthesis pathway, particularly in the C-6 double bond introduction during the C-6 desaturation.",396,8,"K.VYDLTK.F,R.LYMAED.- ,K.STWVILHHK.V ,K.YYTLEEIQK.H ,K.TYIIGELHPDDR.S ,K.FLEEHPGGEEVLR.E ,\nK.TYIIGELHPDDRSK.I ,R.EQAGGDATENFEDVGHSTDAR.E \n "," "]
["IPI00207980","Rpl23 60S ribosomal protein L23",14970,10.51,-0.194,0,"Cytosolic large ribosomal subunit;nucleolus","Structural constituent of ribosome",118,2,"K.GSAITGPVAK.E,R.ISLGLPVGAVINCADNTGAK.N  "," "]
["IPI00213396","RGD1561102 hypothetical protein LOC299713",14955,8.64,-0.183,0,"Ribosome","Structural constituent of ribosome",40,1,"K.LGEWVGLCK.I"]
["IPI00231474","Rps15a 40S ribosomal protein S15a",14944,10.14,-0.12,0,"Cytosolic small ribosomal subunit","Structural constituent of ribosome",75,3,"K.ILGFFF.-,K.SINNAEK.R , R.MNVLADALK.S "," "]
["IPI00768953","LOC687571 similar to cytochrome c oxidase, subunit VIb polypeptide 1",14849,8.36,-0.502,0,"Mitochondrion","This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. This protein may be one of the heme-binding subunits of the oxidase.\n",68,3,"R.FPNQNQTK.N,K.SLCPVSWVSAWDDR.I,K.TAPFDSRFPNQNQTK.N  "," "]
["IPI00361509","RGD1561453 similar to ribosomal protein S12",14838,5.93,-0.204,0,"Cytosolic small ribosomal subunit","Structural constituent of ribosome",40,2,"K.LGEWVGLCK.I,K.TALIHDGLAR.G  "," "]
["IPI00421718","Rpl22 60S ribosomal protein L22",14837,9.06,-0.834,0,"Ribosome","RNA binding,heparin binding,structural constituent of ribosome",118,4,"K.NNLRDWLR.V,K.AGNLGGGVVTIER.S,R.VVANSKESYELR.Y,R.YFQINQDEEEEEDED.-\n "," "]
["IPI00551563","15 kDa protein",14794,9.21,-0.752,0,"Ribosome","Structural constituent of ribosome",118,4,"K.AGNLGGGVVTIER.S,K.ITVTSEVPFSKR.Y ,R.VVANSKESYELR.Y ,R.YFQINQDEEEEEDED.- \n "," "]
["IPI00569434","LOC680996 similar to ribosomal protein S15a",14734,9.88,-0.183,0,"Cytosolic small ribosomal subunit","Structural constituent of ribosome",75,2,"K.SINNAEK.R,-.MNVLADAIK.S"," "]
["IPI00231292","Hrsp12 Ribonuclease UK114",14533,7.8,0.216,0,"Mitochondrion; Cytoplasm; Nucleus; Peroxisome ","Endoribonuclease responsible for the inhibition of the translation by cleaving mRNA. Inhibits cell-free protein synthesis. Cleaves phosphodiester bonds only in single-stranded RNA.",188,4,"K.APAAIGAYSQAVLVDR.T, K.TYFQGNLPAR.A ,K.AAGCDFTNVVK.T ,R.IEIEAIAVQGPFTTAGL.- \n"," "]
["IPI00190790","Fabp1 Fatty acid-binding protein, liver",14320,7.79,-0.432,0,"Cytoplasm","Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.",294,9,"K.MVTTFK.G,K.LTITYGSK.V ,K.GVSEIVHEGK.K ,K.GVSEIVHEGKK.V ,K.AMGLPEDLIQK.G ,K.AMGLPEDLIQK.G + Oxidation (M) ,\nK.YQVQSQENFEPFMK.A ,K.YQVQSQENFEPFMK.A + Oxidation (M) ,K.SVTEFNGDTITNTMTLGDIVYKR.V + Oxidation (M) \n "," "]
["IPI00207486","14 kDa protein   ",14311,10.22,-0.723,0,"Unknown","Unknown",58,1,"K.LYTLVTYVPVTTFK.N"," "]
["IPI00188688","RGD1564767 Histone H2A",14180,10.74,-0.476,0,"Nucleus","DNA binding",52,2,"R.AGLQFPVGR.V,R.VTIAQGGVLPNIQAVLLPK.K  "," "]
["IPI00208707","LOC680988 similar to ribosomal protein S12",14001,8.17,-0.258,0,"Cytosolic small ribosomal subunit","Structural constituent of ribosome",40,2,"K.LGEWVGLCK.I,K.TAIIHDGLAR.G"," "]
["IPI00204359","B2m Beta-2-microglobulin",13825,7.8,-0.142,0,"Extracellular space; cytoplasm (ortholog); external side of plasma membrane (ortholog)","Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. ",59,3,"K.HVTLKEPK.T,K.TVTWDRDM.- + Oxidation (M) ,K.TPQIQVYSR.H "," "]
["IPI00215184","Rps25 40S ribosomal protein S25",13791,10.12,-0.861,0,"Cytosolic small ribosomal subunit;nucleolus","Structural constituent of ribosome",85,3,"R.AQVIYTR.N,R.AALQELLSK.G ,K.LITPAVVSER.L  "," "]
["IPI00192280","14 kDa protein",13745,11.48,-0.541,0,"Ribosome","Structural constituent of ribosome",54,2,"R.LSYNTASNK.T,R.RLSYNTASNK.T  "," "]
["IPI00394551","LOC688948 similar to ribosomal protein S26",13315,10.15,-0.488,0,"Cytosolic small ribosomal subunit","mRNA binding,structural constituent of ribosome",58,1,"R.NIVEAAAVR.D"]
["IPI00213366","13 kDa protein",13283,11.01,-0.663,0,"Unknown","Unknown",110,2,"R.NIVEAAAVR.D,R.DISEASVFDAYVLPK.L "," "]
["IPI00231963","Ddt D-dopachrome decarboxylase",13239,6.09,0.044,0,"Cytoplasm","Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). ",78,2,"R.IPAGLENR.L,R.FFPLEPWQIGK.K  "," "]
["IPI00231346","Rpl30 60S ribosomal protein L30",12947,9.65,-0.295,0,"Cytosolic large ribosomal subunit","Structural constituent of ribosome",111,1,"R.VCTLAIIDPGDSDIIR.S "," "]
["IPI00188509","Dad1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1",12660,6.52,0.825,3,"Membrane; Multi-pass membrane protein (Potential) ","Component of the N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER) (By similarity). Loss of the DAD1 protein triggers apoptosis. ",68,2,"K.ADFQGISPER.A,R.FLEEYLSSTPQR.L  "," "]
["IPI00394133","13 kDa protein",12648,5.66,-0.755,0,"Unknown","Unknown",42,1,"-.FLQEELK.R"]
["IPI00203604","Brp44l Brain protein 44-like protein",12617,9.67,-0.024,0,"Intracellular (ortholog); mitochondrial inner membrane (ortholog) ","A protein that exhibits pyruvate transmembrane transporter activity (ortholog); ",40,2,"R.KAADYVR.S,K.SPEIISGR.M  "," "]
["IPI00193854","Pcbd1 Pterin-4-alpha-carbinolamine dehydratase",12049,6.28,-0.362,0,"Cytoplasm; Nucleus","Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity. ",51,1,"R.LSAEERDQLLPNLR.A "," "]
["IPI00231864","Cycs Cytochrome c, somatic",11712,9.61,-0.757,0,"Mitochondrion intermembrane space","Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.Plays a role in apoptosis. Suppression of the anti- apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.  ",237,5,"R.ADLIAYLK.K ,K.TGPNLHGLFGR.K ,K.TGQAAGFSYTDANK.N ,R.KTGQAAGFSYTDANK.N ,K.TGQAAGFSYTDANKNK.G \n"," "]
["IPI00200145","Rplp1 60S acidic ribosomal protein P1",11605,4.23,0.132,0,"Ribosome","Plays an important role in the elongation step of protein synthesis. ",66,1,"K.AAGVNVEPFWPGLFAK.A"," "]
["IPI00421711","Atp5l ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G",11453,9.57,0.217,0,"Mitochondrion;Mitochondrion inner membrane ","Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. ",212,4,"K.NIIHSAQTGNFK.H,R.VELVPPTLGEIPTAIQSMK.N ,R.VELVPPTLGEIPTAIQSMK.N + Oxidation (M) ,\nR.NLADKAPSMVAAAVTYSKPR.L \n "," "]
["IPI00191103","Ndufa2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2",10952,9.75,-0.301,0,"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side ","Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. ",128,3,"R.SPGSQGVR.D,R.ECSEVQPK.L , K.NVSLNNLSAAEVTK.A "," "]
["IPI00208891","RGD1560186 similar to ribosomal protein L37",10678,11.28,-1.001,0,"Ribosome","Metal ion binding,rRNA binding,structural constituent of ribosome",55,2,"K.RAAVAASSSS.-,M.TKGTSSFGK.R "," "]
["IPI00390086","Atp5j2 similar to ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2",10503,10.09,-0.386,1,"Mitochondrion (By similarity); Mitochondrion inner membrane; Single-pass membrane protein (Potential) ","Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. ",120,5,"K.LMEVK.L + Oxidation (M),R.ELPSWILMR.D ,R.DFTPSGIAGAFR.R ,K.LRELPSWILMR.D ,K.LRELPSWILMR.D + Oxidation (M) \n "," "]
["IPI00389152","Cox6b1-ps1;Cox6b1 similar to cytochrome c oxidase, subunit VIb polypeptide 1",10293,8.96,-0.764,0,"Mitochondrion \n ","This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. This protein may be one of the heme-binding subunits of the oxidase.\n",64,4,"R.FPNQNQTK.N,R.IAEGTFPGKI.- ,K.SLCPVSWVSAWDDR.I,K.TAPFDSRFPNQNQTK.N\n"," "]
["IPI00198200","Dpm3-ps1;Dpm3 dolichyl-phosphate mannosyltransferase polypeptide 3",10255,6.92,0.392,0,"Unknown","Transferase activity, transferring glycosyl groups \n",44,1,"R.ELQSQILEAR.A "]
["IPI00364983","Sec61b Sec61 beta subunit",10039,11.57,-0.118,1,"Membrane","Ribosome binding",97,2,"R.FYTEDSPGLK.V,M.PGPTPSATNVGSSGR.S  "," "]
["IPI00210965","Rps27l 40S ribosomal protein S27-like protein",9813,9.57,-0.446,0,"Nucleus;ribosome","Cysteine-type endopeptidase activator activity involved in apoptotic process,metal ion binding,structural constituent of ribosome,\ntranslation activator activity",50,1,"R.LTEGCSFR.R "]
["IPI00382171","Pxmp2 Liver regeneration-related protein LRRG01",9789,10.28,0.065,0,"Peroxisomal membrane; peroxisome; cytoplasm (ortholog)","INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; dibutyl phthalate",111,4,"K.FYPVVTK.A,R.SLEVSGLLR.Y ,R.LRVESELR.S ,R.ALAQYLLFLK.F \n "," "]
["IPI00870032","RGD1563438 hypothetical protein LOC287442",9437,9.06,0.507,0,"Mitochondrial inner membrane (inferred)","INTERACTS WITH 17beta-estradiol (ortholog); aflatoxin B1 (ortholog); benzo[a]pyrene (ortholog)",58,1,"R.LGALSGAGALSLATYGAHGAQFPDAYGK.E "," "]
["IPI00213436","Ndufa4 RCG28086, isoform CRA_a",9321,9.52,-0.406,1,"Mitochondrial respiratory chain complex I;mitochondrial respiratory chain complex IV","Cytochrome-c oxidase activity",135,7,"R.QILGQAK.K,K.LGPNEQYK.F, K.NNPEPWNK.L,R.KNNPEPWNK.L, K.FYSVNVDYSK.L, PDVSWDR.K,K.LGPNEQYKFYSVNVDYSK.L "," "]
["IPI00190131","Hdhd2 Immediate early response 3-interacting protein 1",9050,7.96,0.804,1,"Endoplasmic reticulum membrane; Multi-pass membrane protein","May be implicated in the regulation of apoptosis By similarity. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus. ",47,1,"K.SQLLNLIR.S "]
["IPI00393196","9 kDa protein",8923,11.76,-0.244,0,"Unknown","Unknown",43,1,"R.ERPGAGAR.R"]
["IPI00230832","Cox6c Cytochrome c oxidase subunit 6C-2",8449,10.07,-0.108,1,"Mitochondrion inner membrane","This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. ",52,4,"K.FGVAEPR.K,K.AYADFYR.N, R.QAGVFQSAK.-, R.NYDSMKDFEEMR.Q  "," "]
["IPI00212270","Gng12 similar to guanine nucleotide binding protein (G protein), gamma 12",8252,9.14,-0.465,0,"Cell membrane; Lipid-anchor; Cytoplasmic side ","Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. ",43,2,"R.LEASIER.I,K.TASTNSTAQAR.R "," "]
["IPI00231978","Atp5i ATP synthase subunit e, mitochondrial",8249,9.34,-0.494,0,"Mitochondrion; Mitochondrion inner membrane ","Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. ",280,4,"R.LDELKR.I,M.VPPVQVSPLIK.F, R.ELAEAEDVSIFK.-, R.IERELAEAEDVSIFK.-  "," "]
["IPI00359978","Rps28 40S ribosomal protein S28",7893,10.7,-0.594,0,"Cytosolic small ribosomal subunit","RNA binding,structural constituent of ribosome",40,2,"R.NVKGPVR.E,R.EGDVLTLLESER.E "," "]
["IPI00195772","Mt-atp8 ATP synthase protein 8",7637,9.3,-0.093,1,"Mitochondrion membrane; Single-pass membrane protein ","Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.",103,2,"K.TNNPWESK.W,K.IYLPLSLPPQ.- "," "]
["IPI00359269","LOC685322 similar to ubiquinol-cytochrome c reductase complex 7.2kDa protein isoform b",7086,9.1,-0.273,0,"Mitochondrial respiratory chain complex III (inferred)","INVOLVED IN mitochondrial electron transport, ubiquinol to cytochrome c (inferred); INTERACTS WITH cobalt dichloride (ortholog); copper(2+) sulfate (ortholog); elemental selenium (ortholog)",45,1,"M.ASPTVTSR.L "]
["IPI00231608","Rps29 40S ribosomal protein S29",6900,10.16,-0.773,0,"Cytosolic small ribosomal subunit","Metal ion binding,structural constituent of ribosome",75,1,"K.DIGFIKLD.- "]
["IPI00202111","Usmg5 Up-regulated during skeletal muscle growth protein 5",6460,9.84,-0.012,1,"Mitochondrion membrane; Single-pass membrane protein","Plays a critical role in maintaining the ATP synthase population in mitochondria. ",60,2,"K.YFNSYTLTGR.M,M.AGPESDGQFQFTGIKK.Y"," "," "]
["IPI00475928","Cytochrome c oxidase subunit 7C, mitochondrial (Fragment)",1116,5.38,-2.21,0,"Mitochondrion inner membrane","Cytochrome-c oxidase activity",45,1,"-.SHYEEGPGK.N "]

{"sheet":"Sheet2","index":1,"n_rows":0,"n_cols":0,"rows_kept":0,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}

{"sheet":"Sheet3","index":2,"n_rows":0,"n_cols":0,"rows_kept":0,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}