{"text_format":"2","workbook":"xls","n_sheets":4,"sheets":["general","Laccase-TEMPO","Hydrogenation","DIAD"],"not_rendered":{"charts":2,"images":0,"macros":0,"external_links":1,"defined_names":0,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"general","index":0,"n_rows":10,"n_cols":11,"rows_kept":10,"cut":false,"hidden":false,"merged":[[5,3,5,5]],"flags":["formulas_cached_only"]}
["Environmental assessment of chemoselective N-debenzylation of compound trans-13a"]
[]
["General remarks:"]
["The E-factor was calculated for non-volatiles, gases and volatile compounds constituting final products. Solvents were treated separately"]
[]
[null,null,null,"E-factor",null,null,null,"Waste classification"]
["method","yield [%]","by-products [%]","overall","reaction","isolation","solvent demand [L/g product]","inorg. salts","organics","by-products","others"]
["Laccase/TEMPO",95,"<3",21.5,3.7,17.8,0.56,17.8,2.8,0.6,0.3]
["Hydrogenation",27,"<3",1106.1,4.5,1101.6,14.02,1101.7,0,4.4,0]
["DIAD",80,"<3",381.09999999999997,7.7,373.4,9.53,378.8,0.234,2.14,0]

{"sheet":"Laccase-TEMPO","index":1,"n_rows":24,"n_cols":8,"rows_kept":24,"cut":false,"hidden":false,"merged":[[0,0,0,8]],"flags":["formulas_cached_only"]}
["Laccase/TEMPO"]
[]
[]
["dibenzylcompound"]
["yield:",0.95]
[]
[]
["Material","(Non)volatile [mg]","(Non)volatile [E]","Solvent [mL]",null,null,"E factor:"]
["Starting Materials",{"$nulls":5},"reaction",3.6874]
["substrate 1a",100,{"$nulls":4},"work-up",17.797]
["O2",12.8,0.112,null,null,null,"purification","na"]
["laccase from T. versicolor",11.6,0.176,null,null,null,"total",21.4844]
["TEMPO",10.6,0.1606]
["tris buffer",17.44,2.642]
["water",null,null,7.2]
[]
["By-Products"]
["Benzaldehyde",null,0.517]
["Remaining diBenzylcompound + other",null,0.0798]
[]
["Auxiliaries (work-up)"]
["Na2SO4",375,5.68]
["NaOH",800,12.117]
["Dichloromethane",null,null,30]

{"sheet":"Hydrogenation","index":2,"n_rows":24,"n_cols":8,"rows_kept":24,"cut":false,"hidden":false,"merged":[[0,0,0,8]],"flags":["formulas_cached_only"]}
["Hydrogenation"]
[]
[]
["dibenzylcompound"]
["yield:",0.27]
[]
[]
["Material","(Non)volatile [mg]","(Non)volatile [E]","Solvent [mL]",null,null,"E factor:"]
["Starting Materials",{"$nulls":5},"reaction",4.547]
["dibenzylcompound",100,{"$nulls":4},"work-up",1101.589]
["H2",0.7,0.001,null,null,null,"purification","na"]
["Pd/C",3.39,0.18,null,null,null,"total",1106.136]
["MeOH",null,null,3.39]
[]
["By-Products"]
["Toluene",null,0.4488]
["remaining dibenzylcompound + others",null,3.9172]
[]
["Auxiliaries (work-up)"]
["Celite",10700,569.42]
["Silica gel",10000,532.169]
["MeOH",null,null,10]
["n-Hexane",null,null,25]
["EtOAc",null,null,225]

{"sheet":"DIAD","index":3,"n_rows":27,"n_cols":8,"rows_kept":27,"cut":false,"hidden":false,"merged":[[0,0,0,8]],"flags":["formulas_cached_only"]}
["DIAD"]
[]
[]
["dibenzylcompound"]
["yield:",0.8]
[]
[]
["Material","(Non)volatile [mg]","(Non)volatile [E]","Solvent [mL]",null,null,"E factor:"]
["Starting Materials",{"$nulls":5},"reaction",7.7135]
["dibenzylcompound",50,{"$nulls":4},"work-up",373.4265]
["DIAD",40,0.2339,null,null,null,"purification","na"]
["water",36,0.02,2.375,null,null,"total",381.14]
["HCl conc (37% aq)",null,5.32,0.125]
["THF",null,null,2]
[]
["By-Products"]
["Benzaldehyde",null,0.5169]
["DIHD",null,0.9948]
["remaining dibenzylcompound + other",null,0.6279]
[]
["Auxiliaries (work-up)"]
["NaOH",240,8.646]
["Na2SO4",125,4.5035]
["Silica gel",100,360.277]
["CH2Cl2",null,null,10]
["n-Hexane",null,null,25]
["EtOAC",null,null,225]