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["Table S2. Differentially expressed proteins identified by iTRAQ from worms at different developmental stages in response to artesunate"]
["KEGG name","No.a","Accessionb","Description","ART1/CON1",null,"ART2/CON2",null,"ART3/CON3"]
[{"$nulls":4},"fold change ","p-value","fold change","p-value","fold change","p-value"]
["Signal transduction","Cell adhesion"]
[null,24,"G4V7C2","Discoidin domain receptor, putative",0.551,1.77e-20,1.265,0.00214,0.799,0.157]
[null,25,"G4VIZ6","Leucine-rich repeat-containing protein, putative ",0.294,3.27e-81,0.856,0.0369,0.514,5.18e-05]
[null,"Glutamatergic synapse"]
[null,26,"G4VQN4","Sh3 and multiple ankyrin repeat domains protein 1,2 (Shank1,2), putative ",0.52,2.18e-24,0.245,1.74e-81,0.877,0.392]
[null,27,"C1L4V2","Uncharacterized protein ",1.144,0.0221,1.328,0.000222,0.647,0.00742]
[null,"Endocytosis and exocytosis"]
[null,4,"G4VG60","Beta-arrestin 1, putative",1.041,0.495,1.413,7e-06,2.795,1.45e-16]
[null,5,"G4V8Q1","Calcium-dependent activator protein for secretion, putative ",1.235,0.000326,1.321,0.000284,1.712,1.92e-05]
[null,"Notch signal pathway"]
[null,12,"C1LEX3","Notchless protein homolog 1 ",0.775,7.01e-05,0.771,0.00044,1.279,0.0563]
[null,"Water reabsorption"]
[null,30,"C1LP58","Aquaporin-3 (AQP-3)",0.636,1.82e-12,1.338,0.00015,1.883,4.45e-07]
[null,31,"G4V9T4","Dynactin subunit P25, putative",0.867,0.0268,1.247,0.00398,0.445,8.99e-07]
[null,"Biological regulation"]
[null,63,"C4QLY6","GTP-binding protein alpha subunit, gna,putative ",0.802,0.000578,1.091,0.247,0.529,0.000104]
[null,64,"C1LGF3","Protein phosphatase inhibitor 2 ",0.772,5.8e-05,1.403,1.06e-05,2.2,2.71e-10]
[null,57,"G4LWI4","Protein kinase ",1.055,0.363,1.698,6.35e-12,0.427,2.42e-07]
[null,65,"C1M0Q3","Serine/threonine kinase ",1.897,1.68e-27,0.82,0.00625,0.787,0.133]
[null,45,"C1L984","Serine/threonine-protein phosphatase 1 regulatory subunit 10 ",0.936,0.302,1.476,4.13e-07,0.462,2.71e-06]
["Stress/defense/detoxification","Porphyrin metabolism"]
[null,34,"Q5BVH5","SJCHGC06865 protein (Fragment) ",0.884,0.0554,1.385,2.29e-05,0.601,0.00183]
[null,"Glutathione metabolism"]
[null,35,"Q5C216","SJCHGC06612 protein (Fragment) ",1.225,0.000551,0.821,0.00776,0.894,0.458]
[null,36,"Q5C2Y3","SJCHGC05326 protein (Fragment) ",0.691,8.67e-09,1.758,2.38e-13,0.969,0.797]
[null,"Metabolism of xenobiotics"]
[null,3,"C1LRC9","Carbonyl reductase 1 ",0.803,0.000654,1.266,0.00208,0.725,0.0462]
[null,"Chaperones"]
[null,37,"C1L8Z6","Stress-induced-phosphoprotein 1, putative",1.273,4.03e-05,1.421,4.94e-06,2.305,2.15e-11]
[null,53,"C1LXK5","Peptidyl-prolyl cis-trans isomerase",0.613,2.65e-14,1.888,1.65e-16,1.403,0.00791]
[null,"Innate immune responses"]
[null,60,"G4M0G8","Trim56 protein, putative",0.824,0.00254,0.653,7.22e-09,0.54,0.000173]
[null,56,"Q95VB7","Albumin ",1.152,0.0158,1.559,8.1e-09,1.776,4.77e-06]
[null,"Mitochondrial biogenesis"]
[null,9,"G4VCR1","Leucine zipper-ef-hand containing transmembrane protein, putative",1.321,2.22e-06,1.324,0.000259,1.103,0.481]
[null,32,"G4VC91","AAA family ATPase, putative ",1.353,2.83e-07,1.018,0.799,2.208,2.22e-10]
[null,"Oxidative phosphorylation"]
[null,59,"C7TZP2","NADH:ubiquinone oxidoreductase complex I intermediate associated protein 30",0.988,0.852,1.456,1.04e-06,0.494,1.78e-05]
[null,28,"G4LZA6","Mitochondrial carrier protein-related ",0.344,3.58e-62,1.079,0.313,0.586,0.00108]
[null,29,"C1LA19","Solute carrier family 31 (Copper transporters), member 1 ",0.903,0.115,0.791,0.00157,0.611,0.00258]
["Cellular iron ion homeostasis",33,"Q5DFU0","Probable cytosolic iron-sulfur protein assembly protein ",0.953,0.456,1.268,0.00197,0.521,7.14e-05]
[null,66,"Q5C2D3","SJCHGC09008 protein (Fragment) ",0.815,0.00142,2.028,4.63e-20,1.163,0.258]
["Matter metablism","Glycolysis"]
[null,1,"Q5C2V0","SJCHGC06560 protein (Fragment) ",0.831,0.00405,0.749,9.26e-05,0.971,0.808]
[null,13,"G4V7H6","Putative glycogen synthase kinase 3-related (Gsk3) ",0.833502,0.00461347,1.04409,0.559143,0.803229,0.167568]
[null,"Citrate cycle (TCA cycle)"]
[null,2,"C1L595","2-oxoglutarate dehydrogenase E2 component ",1.362,1.55e-07,1.363,5.6e-05,1.237,0.103]
[null,"Amino acid metabolism"]
[null,38,"Q5BWI3","SJCHGC08216 protein (Fragment) ",0.733,1.28e-06,1.061,0.431,0.59,0.00127]
[null,39,"Q5BZ92","SJCHGC08924 protein (Fragment) ",0.775,7.46e-05,1.374,3.57e-05,0.664,0.0119]
[null,"Ether lipid metabolism"]
[null,40,"Q5DGC5","SJCHGC04899 protein ",1.044,0.457,1.234,0.00604,0.632,0.00494]
["Protein synthesis/degradation","Ribosome biogenisis "]
[null,10,"C1LIX8","Ribosomal protein L35A ",1.236,0.000319,1.335,0.00017,1.316,0.0327]
[null,11,"C1LWB3","Ribosomal protein, large P2",1.244,0.00021,1.264,0.00222,0.972,0.81]
[null,54,"C1LEG1","39S ribosomal protein L51, mitochondrial ",0.963,0.557,1.294,0.000771,0.636,0.00551]
[null,55,"G4VQW2","60s ribosomal protein L13a, putative",1.238,0.00028,1.552,1.14e-08,1.455,0.00313]
[null,"Ubiquitin mediated proteolysis"]
[null,58,"G4V8L7","SPFH domain / Band 7 family protein, putative ",0.791,0.000271,1.095,0.23,0.605,0.00208]
[null,"Lysosome"]
[null,61,"F6LHS0","CD63 antigen",1.321,2.27e-06,0.804,0.00314,4.771,1.95e-36]
[null,62,"C1L7A5","Cysteine PRotease related protein ",1.691,4.94e-19,1.231,0.00661,2.069,5.99e-09]
["Regulation of gene expression","DNA replication, transcription"]
[null,6,"C1L929","Histone H2A ",1.283,2.34e-05,1.271,0.00179,1.373,0.0131]
[null,7,"C1L511","Nucleolar protein 5A",1.284,2.1e-05,1.274,0.00157,0.973,0.818]
[null,8,"G4VTE7","Nucleotide-binding protein 1 (Nbp 1)/nbp35, putative ",0.738,2.19e-06,0.78,0.000788,0.763,0.091]
[null,41,"Q5DAM4","SJCHGC05077 protein ",0.825,0.00271,1.291,0.000884,1.069,0.655]
[null,42,"Q5BYG3","SJCHGC08144 protein (Fragment) ",1.031,0.597,1.414,6.5e-06,1.52,0.000935]
[null,43,"C7TXT1","Origin recognition complex,subunit 3 isoform 1, putative ",1.081,0.186,1.236,0.00575,0.442,7.25e-07]
[null,44,"Q5C1V9","SJCHGC03611 protein (Fragment) ",0.882,0.0513,1.751,3.55e-13,1.833,1.35e-06]
[null,46,"C1LG30","Regulator of nonsense transcripts 1",0.697,1.86e-08,1.307,0.000493,0.582,0.000924]
[null,"Mismatch repair"]
[null,47,"Q5BXL4","SJCHGC07751 protein (Fragment) ",0.913,0.159,1.286,0.00102,0.585,0.00105]
[null,"Spliceosome"]
[null,48,"C1LHF7","Snurportin-1",0.595,6.6e-16,5.059,6.96e-98,0.289,6.94e-14]
[null,49,"G4V8V3","RNA recognition motif protein split ends, putative",0.733,1.28e-06,1.175,0.035,0.543,0.000201]
[null,50,"Q5C0I0","SJCHGC04461 protein (Fragment) ",0.64,3.39e-12,1.318,0.000324,0.72,0.0415]
[null,51,"Q5C6T1","SJCHGC07823 protein (Fragment) ",1.245,0.000195,1.415,6.24e-06,0.393,1.52e-08]
[null,52,"C1L8F4","Uncharacterized protein ",0.95,0.427,1.329,0.000213,0.493,1.66e-05]
["Unknown",14,"C1LGT8","Hypotheticial protein ",0.797,0.000412,0.722,1.02e-05,0.774,0.109]
[null,15,"Q5DF01","SJCHGC01792 protein ",1.18,0.00479,1.353,8.34e-05,1.534,0.000717]
[null,16,"Q5BXE0","SJCHGC03473 protein (Fragment) ",0.586,9.08e-17,0.795,0.00195,0.437,5.07e-07]
[null,17,"Q5C382","SJCHGC03927 protein (Fragment) ",1.255,0.000115,1.226,0.00769,1.035,0.85]
[null,18,"Q5BWX4","SJCHGC06578 protein (Fragment) ",0.582,3.61e-17,0.887,0.108,1.56,0.00043]
[null,19,"Q5DGF9","SJCHGC06635 protein ",1.441,5.55e-10,1.206,0.0143,1.825,1.63e-06]
[null,20,"Q5C378","SJCHGC07860 protein (Fragment) ",0.808,0.000931,1.117,0.145,0.607,0.00223]
[null,21,"C1L8Y4","Uncharacterized protein ",0.894,0.0817,0.783,0.000968,1.609,0.000161]
[null,22,"C1LCL8","Uncharacterized protein ",0.78,0.000108,0.949,0.491,0.617,0.00313]
[null,23,"Q5C6R9","UPF0506 protein SJCHGC02381",1.064,0.292,0.741,4.94e-05,1.939,1.23e-07]
[null,67,"Q5D9N0","SJCHGC02807 protein ",1.383,3.53e-08,1.258,0.00278,0.657,0.00982]
[null,68,"Q5DF68","SJCHGC03008 protein ",1.025,0.676,0.815,0.00576,1.455,0.00312]
[null,69,"Q5C4P2","SJCHGC03368 protein (Fragment) ",0.615,3.94e-14,1.236,0.00572,0.649,0.008]
[null,70,"Q5BWF1","SJCHGC03443 protein (Fragment) ",1.232,0.0004,1.328,0.000223,0.794,0.146]
[null,71,"Q5BYT3","SJCHGC04132 protein (Fragment) ",0.993,0.919,1.336,0.000159,0.623,0.00368]
[null,72,"Q5BWA1","SJCHGC04178 protein (Fragment) ",0.842,0.00764,1.335,0.000168,0.528,0.000102]
[null,73,"Q5BSG0","SJCHGC04452 protein ",0.714,1.62e-07,0.947,0.473,0.559,0.000387]
[null,74,"Q5D8G7","SJCHGC04498 protein ",0.963,0.56,1.269,0.00187,1.435,0.00452]
[null,75,"Q5BXC2","SJCHGC04719 protein (Fragment) ",0.963,0.564,1.343,0.000125,0.556,0.000341]
[null,76,"Q5DAR6","SJCHGC06344 protein ",0.901,0.104,1.258,0.00278,0.565,0.0005]
[null,77,"Q3KTI9","SJCHGC06411 protein (Fragment) ",0.934,0.287,1.478,3.79e-07,0.519,6.5e-05]
[null,78,"Q5C416","SJCHGC07311 protein (Fragment) ",1.605,9.56e-16,3.463,2.81e-58,0.579,0.000831]
[null,79,"Q5C4G3","SJCHGC07675 protein (Fragment) ",1.074,0.225,1.269,0.00189,0.502,2.73e-05]
[null,80,"Q5C460","SJCHGC07701 protein (Fragment) ",0.963,0.563,1.281,0.00123,0.611,0.00259]
[null,81,"Q5C052","SJCHGC08296 protein (Fragment) ",0.803,0.000647,1.118,0.141,0.507,3.53e-05]
[null,82,"Q5C5M9","SJCHGC08925 protein (Fragment) ",0.932,0.272,1.431,3.19e-06,0.629,0.00445]
[null,83,"C1L467","Uncharacterized protein ",1.032,0.589,1.269,0.00189,0.656,0.00956]
[null,84,"C1LC06","Uncharacterized protein ",0.827,0.00319,0.677,1.28e-07,1.294,0.0452]
[null,85,"G4VGL8","Uncharacterized protein ",0.796,0.000371,1.401,1.14e-05,1.675,4.17e-05]
[null,86,"G4LZV7","Uncharacterized protein, putative",0.827,0.00313,1.028,0.705,0.465,3.38e-06]
[null,87,"G4M1B4","Uncharacterized protein, putative",0.737,2e-06,1.241,0.00475,0.966,0.781]
[null,88,"G4V9Q7","Uncharacterized protein, putative",0.517,7.73e-25,0.675,9.43e-08,2.936,4.77e-18]
[null,89,"G4VHN0","Uncharacterized protein, putative",1.201,0.00187,0.728,1.64e-05,0.838,0.261]
[null,90,"C4QM44","Uncharacterized protein, putative ",2.627,2.19e-60,0.885,0.101,0.328,1.64e-11]
[]
["a  The numbers 1–23 represent 23 drug-related only proteins (DROPs) and 24–90 represent 67 aging and drug-related proteins (ADRPs);  "]
["b Accession means the protein IDs in the UniProt database (http://www.uniprot.org/)."]