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["Supplementary Table S6."]
["Analysis results of Kyoto Encyclopedia of Genes and Genomes (KEGG) annotations of cluster signatures. "]
["The analysis results are downloaded from DAVID website and KEGG pathways with a p<0.1 are considered as most enriched terms."]
[]
["Cluster No.","Regulation Orientation","Category","Term","Count","%","P Value","Genes","List Total","Pop Hits","Pop Total","Fold Enrichment","Bonferroni","Benjamini","FDR"]
["V1","up","KEGG_PATHWAY","hsa00970:Aminoacyl-tRNA biosynthesis",6,2.51046025104602,0.000402625522236534,"204744_S_AT, 201475_X_AT, 200079_S_AT, 200629_AT, 201000_AT, 212048_S_AT, 200628_S_AT",89,31,4190,9.11199710039869,0.0425600856627236,0.0425600856627236,0.452421234270938]
["V1","up","KEGG_PATHWAY","hsa05120:Epithelial cell signaling in Helicobacter pylori infection",6,2.51046025104602,0.00984187354178074,"203510_AT, 201464_X_AT, 204470_AT, 202625_AT, 209896_S_AT, 203266_S_AT",89,63,4190,4.48368111289459,0.656369212648521,0.41379970372621,10.5390946463781]
["V1","up","KEGG_PATHWAY","hsa04010:MAPK signaling pathway",11,4.60251046025104,0.0320431363058551,"201464_X_AT, 209383_AT, 203097_S_AT, 203617_X_AT, 200779_AT, 209189_AT, 210621_S_AT, 201461_S_AT, 202431_S_AT, 204421_S_AT, 203266_S_AT",89,246,4190,2.10514296154197,0.97032105893659,0.690389177017984,30.6991506944264]
["V1","up","KEGG_PATHWAY","hsa04920:Adipocytokine signaling pathway",5,2.09205020920502,0.0466226583732447,"206359_AT, 201963_AT, 209185_S_AT, 201660_AT, 209896_S_AT",89,65,4190,3.62143474503025,0.994237628985299,0.724481792493182,41.5853369283471]
["V1","up","KEGG_PATHWAY","hsa04310:Wnt signaling pathway",7,2.92887029288702,0.0612081072726667,"203460_S_AT, 201464_X_AT, 203230_AT, 204420_AT, 201375_S_AT, 209455_AT, 202431_S_AT",89,134,4190,2.45933255072949,0.998909846415125,0.744437258995566,50.894450652478]
["V1","up","KEGG_PATHWAY","hsa05210:Colorectal cancer",5,2.09205020920502,0.089369179177046,"203510_AT, 201464_X_AT, 203230_AT, 209189_AT, 202431_S_AT",89,81,4190,2.90608961020946,0.999959358167835,0.814577593607067,65.1506503452871]
["V1","up","KEGG_PATHWAY","hsa04120:Ubiquitin mediated proteolysis",6,2.51046025104602,0.0981670358121295,"206359_AT, 202346_AT, 209455_AT, 218340_S_AT, 209416_S_AT, 200667_AT",89,117,4190,2.41428983002016,0.999985756411305,0.796923384049844,68.7593681490429]
["V1","down","KEGG_PATHWAY","hsa04512:ECM-receptor interaction",5,2.12765957446808,0.0326181178386864,"217430_X_AT, 213870_AT, 216654_AT, 215775_AT, 207389_AT",64,81,4190,4.04128086419753,0.947734213331993,0.947734213331993,30.2311803435005]
["V1","down","KEGG_PATHWAY","hsa04510:Focal adhesion",7,2.97872340425531,0.0641765001379497,"221244_S_AT, 220566_AT, 217430_X_AT, 213870_AT, 216654_AT, 215775_AT, 206330_S_AT",64,190,4190,2.41200657894736,0.997269380040092,0.947744665727722,51.3254928857273]
["V1","down","KEGG_PATHWAY","hsa03040:Spliceosome",5,2.12765957446808,0.0823349413523878,"214941_S_AT, 212384_AT, 206108_S_AT, 213649_AT, 212027_AT",64,110,4190,2.97585227272727,0.999522587908812,0.921843613604306,60.6517306451368]
["V2","up","KEGG_PATHWAY","hsa04010:MAPK signaling pathway",13,5.5793991416309,0.00441011757382157,"205463_S_AT, 214284_S_AT, 201044_X_AT, 202340_X_AT, 205027_S_AT, 221401_AT, 203725_AT, 216061_X_AT, 204121_AT, 220780_AT, 206814_AT, 215499_AT, 32541_AT",88,246,4190,2.51616777531411,0.379572206554649,0.379572206554649,4.85496358643878]
["V2","up","KEGG_PATHWAY","hsa04610:Complement and coagulation cascades",5,2.14592274678111,0.049410230843086,"212067_S_AT, 204363_AT, 210845_S_AT, 211920_AT, 211668_S_AT",88,67,4190,3.55325644504748,0.995799909289123,0.935191893170093,43.4799366660376]
["V2","down","KEGG_PATHWAY","hsa03010:Ribosome",15,7.3170731707317,3.40944318223223e-11,"214042_S_AT, 200936_AT, 200026_AT, 200088_X_AT, 221476_S_AT, 200002_AT, 200082_S_AT, 211666_X_AT, 211073_X_AT, 201132_AT, 201217_X_AT, 213687_S_AT, 208692_AT, 216247_AT, 217092_X_AT, 212433_X_AT, 214167_S_AT",69,85,4190,10.7161125319693,3.92085530709351e-09,3.92085530709351e-09,3.88362897396632e-08]
["V2","down","KEGG_PATHWAY","hsa04720:Long-term potentiation",5,2.4390243902439,0.0194322334476781,"202429_S_AT, 213093_AT, 202432_AT, 201408_AT, 214352_S_AT",69,64,4190,4.74411231884058,0.895305109865044,0.676434102330057,20.0307401526745]
["V2","down","KEGG_PATHWAY","hsa04360:Axon guidance",6,2.92682926829268,0.0365610652450915,"203510_AT, 202429_S_AT, 208877_AT, 202432_AT, 213044_AT, 214352_S_AT",69,114,4190,3.19603356216628,0.986203077864687,0.760156803030144,34.5748995981821]
["V2","down","KEGG_PATHWAY","hsa04530:Tight junction",6,2.92682926829268,0.0454278457693118,"211983_X_AT, 213093_AT, 202545_AT, 201375_S_AT, 211995_X_AT, 214352_S_AT, 221607_X_AT, 213214_X_AT, 205079_S_AT",69,121,4190,3.01113905856988,0.995235607140293,0.737274703233098,41.1149072992471]
["V2","down","KEGG_PATHWAY","hsa05130:Pathogenic Escherichia coli infection",4,1.95121951219512,0.05385034481194,"211983_X_AT, 213093_AT, 214848_AT, 200639_S_AT, 213044_AT, 211995_X_AT, 221607_X_AT, 200638_S_AT, 213214_X_AT",69,53,4190,4.58299152310637,0.998280583561102,0.72005274402845,46.769203575758]
["V2","down","KEGG_PATHWAY","hsa04114:Oocyte meiosis",5,2.4390243902439,0.0611486691467723,"202429_S_AT, 214848_AT, 200639_S_AT, 201375_S_AT, 202432_AT, 201408_AT, 200638_S_AT",69,92,4190,3.30025204788909,0.999294275788467,0.701618080905519,51.2633635876512]
["V2","down","KEGG_PATHWAY","hsa04660:T cell receptor signaling pathway",5,2.4390243902439,0.0849442418723865,"202429_S_AT, 208877_AT, 202432_AT, 214352_S_AT, 202515_AT",69,103,4190,2.94779794568735,0.99996314730979,0.767384603543151,63.6205341615204]
["V2","down","KEGG_PATHWAY","hsa04510:Focal adhesion",7,3.41463414634146,0.0861359886695845,"203510_AT, 201656_AT, 211983_X_AT, 213093_AT, 208877_AT, 213044_AT, 211995_X_AT, 201408_AT, 221607_X_AT, 213214_X_AT",69,190,4190,2.2372234935164,0.999968276499482,0.726049159057774,64.1565911288292]
["V3","up","KEGG_PATHWAY","hsa04730:Long-term depression",6,2.54237288135593,0.00428085632772147,"206927_S_AT, 220231_AT, 206917_AT, 211555_S_AT, 209685_S_AT, 204763_S_AT",71,65,4190,5.4474539544962,0.337572632455008,0.337572632455008,4.61514961531357]
["V3","up","KEGG_PATHWAY","hsa04920:Adipocytokine signaling pathway",4,1.69491525423728,0.0937695301338505,"218292_S_AT, 209239_AT, 221453_AT, 206870_AT",71,65,4190,3.63163596966413,0.999921492457865,0.991139551809626,66.1913374199757]
["V3","down","KEGG_PATHWAY","hsa03050:Proteasome",7,2.90456431535269,0.000487757321309003,"200830_AT, 200039_S_AT, 202659_AT, 201762_S_AT, 200876_S_AT, 201068_S_AT, 208827_AT",104,42,4190,6.71474358974358,0.051326553064134,0.051326553064134,0.547842721876201]
["V3","down","KEGG_PATHWAY","hsa05016:Huntington's disease",12,4.97925311203319,0.00145574558470172,"213373_S_AT, 208972_S_AT, 203606_AT, 201568_AT, 203189_S_AT, 211300_S_AT, 200613_AT, 213758_AT, 202839_S_AT, 211730_S_AT, 212955_S_AT, 203190_AT, 202298_AT",104,157,4190,3.07937285644292,0.145582279640985,0.0756528139497506,1.62698354520446]
["V3","down","KEGG_PATHWAY","hsa05010:Alzheimer's disease",11,4.56431535269709,0.00256882375836088,"202839_S_AT, 213373_S_AT, 202535_AT, 208972_S_AT, 203606_AT, 203190_AT, 201568_AT, 202298_AT, 204247_S_AT, 203189_S_AT, 213758_AT, 218302_AT",104,144,4190,3.07759081196581,0.242544065467399,0.0884388851985614,2.85467948623623]
["V3","down","KEGG_PATHWAY","hsa00190:Oxidative phosphorylation",9,3.73443983402489,0.00350393761243236,"202839_S_AT, 208972_S_AT, 202961_S_AT, 203606_AT, 203190_AT, 201568_AT, 202298_AT, 203189_S_AT, 203880_AT, 213758_AT",104,103,4190,3.52035100821508,0.315515859640566,0.0904201151292669,3.87527637123881]
["V3","down","KEGG_PATHWAY","hsa05012:Parkinson's disease",8,3.31950207468879,0.0114753485440918,"211152_S_AT, 202839_S_AT, 208972_S_AT, 203606_AT, 203190_AT, 201568_AT, 202298_AT, 203189_S_AT, 213758_AT",104,101,4190,3.19116527037319,0.712491665949142,0.220654400342092,12.1869059002675]
["V3","down","KEGG_PATHWAY","hsa00563:Glycosylphosphatidylinositol(GPI)-anchor biosynthesis",3,1.24481327800829,0.0780335888515131,"51146_AT, 217770_AT, 209391_AT",104,19,4190,6.36133603238866,0.999845392443226,0.768328939771012,59.9417561756774]
["V3","down","KEGG_PATHWAY","hsa00480:Glutathione metabolism",4,1.65975103734439,0.078524583690548,"205439_AT, 203815_AT, 215333_X_AT, 201193_AT",104,41,4190,3.93058161350844,0.999854036133192,0.716837947647742,60.1813116430937]
["V4","up","KEGG_PATHWAY","hsa04623:Cytosolic DNA-sensing pathway",7,3.34928229665071,0.000168617238223513,"34689_AT, 204533_AT, 205875_S_AT, 204655_AT, 211366_X_AT, 211368_S_AT, 208436_S_AT, 209970_X_AT, 201786_S_AT, 221666_S_AT",75,48,4190,8.14722222222222,0.0160582882865635,0.0160582882865635,0.185557766490318]
["V4","up","KEGG_PATHWAY","hsa04612:Antigen processing and presentation",8,3.82775119617224,0.000390360539477937,"210514_X_AT, 211911_X_AT, 200904_AT, 200814_AT, 216526_X_AT, 208729_X_AT, 217456_X_AT, 202902_S_AT, 201762_S_AT, 216231_S_AT, 202307_S_AT, 209140_X_AT, 200905_X_AT, 211529_X_AT",75,78,4190,5.72991452991453,0.0367881752711723,0.0185664440580668,0.429102482752774]
["V4","up","KEGG_PATHWAY","hsa03050:Proteasome",6,2.87081339712918,0.000766498133257476,"210460_S_AT, 202659_AT, 209040_S_AT, 201762_S_AT, 204279_AT, 200814_AT",75,42,4190,7.98095238095238,0.0709679452068262,0.0242387519373783,0.840986028551904]
["V4","up","KEGG_PATHWAY","hsa04620:Toll-like receptor signaling pathway",7,3.34928229665071,0.00686666215698918,"210163_AT, 204533_AT, 211122_S_AT, 204655_AT, 209969_S_AT, 208641_S_AT, 208436_S_AT, 202743_AT, 200887_S_AT",75,97,4190,4.03161512027491,0.483909546681284,0.152418524388428,7.30818835497798]
["V4","up","KEGG_PATHWAY","hsa04650:Natural killer cell mediated cytotoxicity",7,3.34928229665071,0.0171279400245324,"210514_X_AT, 202688_AT, 211911_X_AT, 200904_AT, 208641_S_AT, 202743_AT, 216526_X_AT, 208729_X_AT, 217456_X_AT, 206247_AT, 209140_X_AT, 200905_X_AT, 211529_X_AT",75,118,4190,3.31412429378531,0.809580684108966,0.28230123301219,17.3273065991844]
["V4","up","KEGG_PATHWAY","hsa04062:Chemokine signaling pathway",7,3.34928229665071,0.0747373260384385,"210163_AT, 204533_AT, 211122_S_AT, 205842_S_AT, 204655_AT, 209969_S_AT, 208641_S_AT, 202743_AT, 200887_S_AT",75,168,4190,2.32777777777777,0.999422643455054,0.711436974871482,57.4945836853258]
["V4","down","KEGG_PATHWAY","hsa00640:Propanoate metabolism",3,1.26582278481012,0.0636731030415929,"49452_AT, 43427_AT, 201425_AT, 209459_S_AT",63,28,4190,7.12585034013605,0.99928050976594,0.99928050976594,52.4466891252916]
["V4","down","KEGG_PATHWAY","hsa00650:Butanoate metabolism",3,1.26582278481012,0.0848957915838267,"201425_AT, 209459_S_AT, 210377_AT",63,33,4190,6.04617604617604,0.999942222228554,0.992398830915884,63.298425568166]
["V5","up","KEGG_PATHWAY","hsa03040:Spliceosome",9,3.78151260504201,0.000282899799856862,"204658_AT, 218053_AT, 209161_AT, 203053_AT, 200058_S_AT, 216457_S_AT, 217822_AT, 219913_S_AT, 202230_S_AT",67,110,4190,5.11668928086838,0.0265212503655014,0.0265212503655014,0.310525681158113]
["V5","up","KEGG_PATHWAY","hsa04662:B cell receptor signaling pathway",5,2.10084033613445,0.0225782804980238,"203927_AT, 212983_AT, 204369_AT, 209666_S_AT, 209239_AT",67,69,4190,4.531689379191,0.885767782247807,0.662017429810067,22.1998011905284]
["V5","up","KEGG_PATHWAY","hsa05221:Acute myeloid leukemia",4,1.68067226890756,0.0572889499126474,"212983_AT, 204369_AT, 209666_S_AT, 209239_AT",67,56,4190,4.46695095948827,0.996318991796648,0.845597049482882,47.7160589694838]
["V5","up","KEGG_PATHWAY","hsa04660:T cell receptor signaling pathway",5,2.10084033613445,0.0779632279888567,"203927_AT, 212983_AT, 204369_AT, 209666_S_AT, 209239_AT",67,103,4190,3.03579191421533,0.999552201170554,0.854530904494283,59.0257531713587]
["V5","up","KEGG_PATHWAY","hsa04920:Adipocytokine signaling pathway",4,1.68067226890756,0.0818161170292783,"210069_AT, 203927_AT, 210070_S_AT, 209666_S_AT, 209239_AT",67,65,4190,3.84845005740528,0.999699172039524,0.802456092580248,60.8689861190448]
["V5","down","KEGG_PATHWAY","hsa04270:Vascular smooth muscle contraction",7,3.04347826086956,0.0225826651252404,"32625_AT, 202545_AT, 222256_S_AT, 206923_AT, 201408_AT, 220423_AT, 215195_AT, 206248_AT",92,102,4190,3.12553282182438,0.941125856034538,0.941125856034538,23.1843273798731]
["V5","down","KEGG_PATHWAY","hsa04666:Fc gamma R-mediated phagocytosis",6,2.60869565217391,0.0448392293305497,"209355_S_AT, 202545_AT, 222256_S_AT, 206923_AT, 222236_S_AT, 215195_AT, 206248_AT",92,90,4190,3.03623188405797,0.996615588340995,0.941824303536578,41.1245358225717]
["V5","down","KEGG_PATHWAY","hsa00561:Glycerolipid metabolism",4,1.7391304347826,0.0483966863327346,"209355_S_AT, 201900_S_AT, 211026_S_AT, 220675_S_AT",92,38,4190,4.79405034324942,0.997869226619694,0.871319594485044,43.6074991435274]
["V5","down","KEGG_PATHWAY","hsa00360:Phenylalanine metabolism",3,1.30434782608695,0.0569817806608391,"200844_S_AT, 220675_S_AT, 204041_AT",92,18,4190,7.59057971014492,0.999307387455672,0.837773204983551,49.210699919027]
["V5","down","KEGG_PATHWAY","hsa05412:Arrhythmogenic right ventricular cardiomyopathy (ARVC)",5,2.17391304347826,0.0591887124313394,"206891_AT, 209663_S_AT, 201125_S_AT, 62987_R_AT, 212762_S_AT",92,68,4190,3.3487851662404,0.999482020713805,0.779777099377892,50.5664308760007]
["V5","down","KEGG_PATHWAY","hsa04664:Fc epsilon RI signaling pathway",5,2.17391304347826,0.0759384362457109,"202545_AT, 222256_S_AT, 206923_AT, 220423_AT, 215195_AT, 206248_AT",92,74,4190,3.07726204465334,0.999944164248335,0.804497614415312,59.8270874617889]
["V5","down","KEGG_PATHWAY","hsa00590:Arachidonic acid metabolism",4,1.7391304347826,0.0936307761807625,"209160_AT, 222256_S_AT, 216661_X_AT, 220423_AT",92,50,4190,3.64347826086956,0.999994920293097,0.824736598443743,67.8645900147795]
["V5","down","KEGG_PATHWAY","hsa04512:ECM-receptor interaction",5,2.17391304347826,0.0981750167262654,"201287_S_AT, 204534_AT, 213290_AT, 209663_S_AT, 201125_S_AT",92,81,4190,2.81132581857219,0.999997276292051,0.798444308002346,69.6766569299596]