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["Supplementary Table S7."]
["List of functional annotation clustering results for each cluster signature."]
["The enriched annotation terms including GO BPs (p < 0.001) and KEGG pathways (p < 0.1) are used for functional annotation clustering."]
[]
["Cluster No.","Category code","Cluster examplar","Cluster Member"]
["V1","Ⅰ.1.1","hsa04510:Focal adhesion","hsa04510:Focal adhesion"]
[null,null,null,"hsa04512:ECM-receptor interaction"]
[null,"Ⅲ.1.1","GO:0016071~mRNA metabolic process","GO:0016071~mRNA metabolic process"]
[null,"Ⅲ.3.1","hsa03040:Spliceosome","hsa03040:Spliceosome"]
[null,"Ⅲ.4.2","GO:0043038~amino acid activation","GO:0006418~tRNA aminoacylation for protein translation"]
[null,null,null,"GO:0043038~amino acid activation"]
[null,null,null,"GO:0043039~tRNA aminoacylation"]
[null,null,null,"hsa00970:Aminoacyl-tRNA biosynthesis"]
[null,"Ⅳ.2.1","GO:0010033~response to organic substance","GO:0009615~response to virus"]
[null,null,null,"GO:0009991~response to extracellular stimulus"]
[null,null,null,"GO:0010033~response to organic substance"]
[null,null,null,"GO:0031668~cellular response to extracellular stimulus"]
[null,null,null,"GO:0051789~response to protein stimulus"]
[null,null,null,"hsa04010:MAPK signaling pathway"]
[null,null,null,"hsa04120:Ubiquitin mediated proteolysis"]
[null,null,null,"hsa04310:Wnt signaling pathway"]
[null,null,null,"hsa04920:Adipocytokine signaling pathway"]
[null,null,null,"hsa05120:Epithelial cell signaling in Helicobacter pylori infection"]
[null,null,null,"hsa05210:Colorectal cancer"]
["V2","Ⅰ.2.1","GO:0008104~protein localization","GO:0006606~protein import into nucleus"]
[null,null,null,"GO:0006886~intracellular protein transport"]
[null,null,null,"GO:0006913~nucleocytoplasmic transport"]
[null,null,null,"GO:0008104~protein localization"]
[null,null,null,"GO:0015031~protein transport"]
[null,null,null,"GO:0017038~protein import"]
[null,null,null,"GO:0033365~protein localization in organelle"]
[null,null,null,"GO:0034504~protein localization in nucleus"]
[null,null,null,"GO:0034613~cellular protein localization"]
[null,null,null,"GO:0045184~establishment of protein localization"]
[null,null,null,"GO:0046907~intracellular transport"]
[null,null,null,"GO:0051169~nuclear transport"]
[null,null,null,"GO:0051170~nuclear import"]
[null,null,null,"GO:0070727~cellular macromolecule localization"]
[null,null,null,"hsa05130:Pathogenic Escherichia coli infection"]
[null,"Ⅱ.2.1","hsa04720:Long-term potentiation","hsa04114:Oocyte meiosis"]
[null,null,null,"hsa04360:Axon guidance"]
[null,null,null,"hsa04510:Focal adhesion"]
[null,null,null,"hsa04530:Tight junction"]
[null,null,null,"hsa04660:T cell receptor signaling pathway"]
[null,null,null,"hsa04720:Long-term potentiation"]
[null,"Ⅲ.2.1","GO:0006412~translation","GO:0006412~translation"]
[null,null,null,"GO:0006414~translational elongation"]
[null,null,null,"hsa03010:Ribosome"]
[null,"Ⅳ.2.2","GO:0007610~behavior","GO:0006955~immune response"]
[null,null,null,"GO:0007610~behavior"]
[null,null,null,"GO:0007626~locomotory behavior"]
[null,null,null,"GO:0009611~response to wounding"]
[null,null,null,"hsa04010:MAPK signaling pathway"]
[null,null,null,"hsa04610:Complement and coagulation cascades"]
["V3","Ⅰ.1.1","GO:0007049~cell cycle","GO:0007049~cell cycle"]
[null,null,null,"GO:0010498~proteasomal protein catabolic process"]
[null,null,null,"GO:0022402~cell cycle process"]
[null,null,null,"GO:0031396~regulation of protein ubiquitination"]
[null,null,null,"GO:0031397~negative regulation of protein ubiquitination"]
[null,null,null,"GO:0031398~positive regulation of protein ubiquitination"]
[null,null,null,"GO:0043161~proteasomal ubiquitin-dependent protein catabolic process"]
[null,null,null,"hsa03050:Proteasome"]
[null,"Ⅱ.2.2","hsa04730:Long-term depression","hsa04730:Long-term depression"]
[null,"Ⅱ.3.1","hsa04920:Adipocytokine signaling pathway","hsa04920:Adipocytokine signaling pathway"]
[null,"Ⅲ.4.3","hsa00480:Glutathione metabolism","hsa00480:Glutathione metabolism"]
[null,"Ⅲ.5.1","hsa00563:Glycosylphosphatidylinositol(GPI)-anchor biosynthesis","hsa00563:Glycosylphosphatidylinositol(GPI)-anchor biosynthesis"]
[null,"Ⅴ.1.1","hsa05010:Alzheimer's disease","GO:0022900~electron transport chain"]
[null,null,null,"hsa00190:Oxidative phosphorylation"]
[null,null,null,"hsa05010:Alzheimer's disease"]
[null,null,null,"hsa05012:Parkinson's disease"]
[null,null,null,"hsa05016:Huntington's disease"]
["V4","Ⅱ.1.1","hsa04620:Toll-like receptor signaling pathway","hsa04062:Chemokine signaling pathway"]
[null,null,null,"hsa04620:Toll-like receptor signaling pathway"]
[null,null,null,"hsa04623:Cytosolic DNA-sensing pathway"]
[null,"Ⅱ.1.4","GO:0006955~immune response","GO:0002474~antigen processing and presentation of peptide antigen via MHC class I"]
[null,null,null,"GO:0006952~defense response"]
[null,null,null,"GO:0006955~immune response"]
[null,null,null,"GO:0006974~response to DNA damage stimulus"]
[null,null,null,"GO:0009615~response to virus"]
[null,null,null,"GO:0019882~antigen processing and presentation"]
[null,null,null,"GO:0048002~antigen processing and presentation of peptide antigen"]
[null,null,null,"hsa03050:Proteasome"]
[null,null,null,"hsa04612:Antigen processing and presentation"]
[null,null,null,"hsa04650:Natural killer cell mediated cytotoxicity"]
[null,"Ⅲ.6.1","hsa00640:Propanoate metabolism","hsa00640:Propanoate metabolism"]
[null,null,null,"hsa00650:Butanoate metabolism"]
["V5","Ⅰ.1.1","GO:0007049~cell cycle","GO:0000075~cell cycle checkpoint"]
[null,null,null,"GO:0000087~M phase of mitotic cell cycle"]
[null,null,null,"GO:0000278~mitotic cell cycle"]
[null,null,null,"GO:0000279~M phase"]
[null,null,null,"GO:0000280~nuclear division"]
[null,null,null,"GO:0006974~response to DNA damage stimulus"]
[null,null,null,"GO:0007049~cell cycle"]
[null,null,null,"GO:0007051~spindle organization"]
[null,null,null,"GO:0007059~chromosome segregation"]
[null,null,null,"GO:0007067~mitosis"]
[null,null,null,"GO:0022402~cell cycle process"]
[null,null,null,"GO:0022403~cell cycle phase"]
[null,null,null,"GO:0048285~organelle fission"]
[null,null,null,"GO:0051301~cell division"]
[null,null,"GO:0006403~RNA localization","GO:0006403~RNA localization"]
[null,null,null,"GO:0015931~nucleobase, nucleoside, nucleotide and nucleic acid transport"]
[null,null,null,"GO:0050657~nucleic acid transport"]
[null,null,null,"GO:0050658~RNA transport"]
[null,null,null,"GO:0051028~mRNA transport"]
[null,null,null,"GO:0051236~establishment of RNA localization"]
[null,"Ⅱ.1.2","hsa04662:B cell receptor signaling pathway","hsa04660:T cell receptor signaling pathway"]
[null,null,null,"hsa04662:B cell receptor signaling pathway"]
[null,null,null,"hsa04920:Adipocytokine signaling pathway"]
[null,null,null,"hsa05221:Acute myeloid leukemia"]
[null,"Ⅱ.1.3","hsa04664:Fc epsilon RI signaling pathway","hsa00590:Arachidonic acid metabolism"]
[null,null,null,"hsa04270:Vascular smooth muscle contraction"]
[null,null,null,"hsa04664:Fc epsilon RI signaling pathway"]
[null,null,null,"hsa04666:Fc gamma R-mediated phagocytosis"]
[null,"Ⅲ.1.2","GO:0045935~positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process","GO:0010628~positive regulation of gene expression"]
[null,null,null,"GO:0045935~positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"]
[null,null,null,"GO:0051173~positive regulation of nitrogen compound metabolic process"]
[null,"Ⅲ.1.3","GO:0006396~RNA processing","GO:0006396~RNA processing"]
[null,null,null,"GO:0006397~mRNA processing"]
[null,null,null,"GO:0008380~RNA splicing"]
[null,null,null,"GO:0016071~mRNA metabolic process"]
[null,null,null,"hsa03040:Spliceosome"]
[null,"Ⅲ.4.1","hsa00360:Phenylalanine metabolism","hsa00360:Phenylalanine metabolism"]
[null,null,null,"hsa00561:Glycerolipid metabolism"]
[null,"Ⅳ.1.1","hsa04512:ECM-receptor interaction","hsa04512:ECM-receptor interaction"]
[null,null,null,"hsa05412:Arrhythmogenic right ventricular cardiomyopathy (ARVC)"]