{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["Community_Sig_Matched_GWAS"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":0,"defined_names":0,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Community_Sig_Matched_GWAS","index":0,"n_rows":1836,"n_cols":35,"rows_kept":1836,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["Supplementary Table S8."]
["List of Genome-Wide Association Studies (GWAS)  disease/trais gene mapping results for each cluster signature."]
["A Published GWAS Catalog available at: www.genome.gov/gwastudies (accessed in July 15, 2013) was used as a reference of disease/trait related genes."]
[]
["Community Signature","Date Added to Catalog","PUBMEDID","First Author","Date","Journal","Link","Study","Disease/Trait","Initial Sample Size","Replication Sample Size","Region","Chr_id","Chr_pos","Reported Gene(s)","Mapped_gene"," (up-regulated)stream_gene_id"," (down-regulated)stream_gene_id","Snp_gene_ids"," (up-regulated)stream_gene_distance"," (down-regulated)stream_gene_distance","Strongest SNP-Risk Allele","SNPs","Merged","Snp_id_current","Context","Intergenic","Risk Allele Frequency","p-Value","Pvalue_mlog","p-Value (text)","OR or beta",95,"Platform [SNPs passing QC]","CNV"]
["V1 (up-regulated)","06/27/2013",23541324,"Li X","03/27/2013","J Allergy Clin Immunol","http://www.ncbi.nlm.nih.gov/pubmed/23541324","Genome-wide association study identifies T<sub>H</sub>1 pathway genes associated with lung function in asthmatic patients.","Pulmonary function in asthmatics","1,544 European ancestry individuals",null,"18p11.32",18,849178,"YES1",null,7525,116,null,36.85,55.77,"rs1291183-T","rs1291183",0,1291183,null,1,0.3,4e-06,5.39794000867203,"(ppFEV1)",0.18,"[NR] unit decrease","Illumina [369,771]","N"]
["V1 (up-regulated)","06/26/2013",23508266,"Duan QL","03/19/2013","Pharmacogenomics J","http://www.ncbi.nlm.nih.gov/pubmed/23508266","A genome-wide association study of bronchodilator response in asthmatics.","Asthma (bronchodilator response)"," (up-regulated) to 403 European ancestry asthmatic children and their parents","764 European ancestry cases, 592 Costa Rican ancestry cases","10p15.1",10,4240870,"PRKCQ,IL15RA,IL2RA,KLF6",null,1316,338588,null,413.4,457.48,"rs11252394-A","rs11252394",0,11252394,null,1,0.08,2e-07,6.69897000433601,"(Additive Model)","NR","NR","Illumina [534,290]","N"]
["V1 (up-regulated)","04/11/2013",23314186,"Crosslin DR","03/03/2013","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23314186 ","Genetic variation associated with circulating monocyte count in the eMERGE Network.","Monocyte count","9,849 European ancestry individuals, 894 African ancestry individuals, 271 other ancestry individuals","NR","3q21.3",3,128338600,"RPN1","- ",null,null,6184,null,null,"rs2712381-A","rs2712381",0,2712381,"nearGene-3",0,0.4,2e-16,15.698970004336,null,0.23,"unit decrease","Illumina [NR]","N"]
["V1 (up-regulated)","05/31/2013",23449627,"Cousminer DL","02/27/2013","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23449627","Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.","Pubertal anthropometrics"," (up-regulated) to 5,043 European ancestry males,  (up-regulated) to 5,756 European ancestry females",null,"6p21.33",6,31360255,"MICA,VARS2",null,267015,100507436,null,9.99,7.31,"rs7751505-C","rs7751505",0,7751505,null,1,0.28,4e-06,5.39794000867203,"(Pubertal growth)",0.07,"[0.041-0.099] unit decrease","Illumina & Affymetrix [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","06/06/2013",23419831,"Ramanan VK","02/19/2013","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23419831","APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.","Alzheimer's disease biomarkers","555 European ancestry individuals","NR","19q13.32",19,45392254,"PVRL2","- ",null,null,5819,null,null,"rs6857-T","rs6857",0,6857,"UTR-3",0,0.28,1e-10,10,"(Cortical Ab)","NR","NR","Illumina [6,108,668] (imputed)","N"]
["V1 (up-regulated)","06/06/2013",23417110,"Tin A","02/16/2013","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23417110","Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin.","Beta-2 microglubulin plasma levels","6,728 European ancestry individuals",null,"6p21.33",6,31405617,"MICA",null,100507436,267016,null,22.53,24.01,"rs2596466-C","rs2596466",0,2596466,null,1,0.07,2e-12,11.698970004336,null,0.05,"[0.034-0.066] unit decrease","Affymetrix [2.5 million] (Imputed)","N"]
["V1 (up-regulated)","05/14/2013",23408906,"Porcu E","02/07/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23408906","A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.","Thyroid hormone levels"," (up-regulated) to 12,289 European ancestry females,  (up-regulated) to 9,019 European ancestry males,  (up-regulated) to 433 Old Order Amish females,  (up-regulated) to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males","NR","6p21.1",6,43811762,"VEGFA",null,7422,221416,null,57.54,156.58,"rs9472138-T ","rs9472138",0,9472138,null,1,0.285,7e-16,15.1549019599857,"(TSH)",0.08,"[0.059-0.099] unit decrease","Illumina, Affymetrix [~2.5 Million] (Imputed)","N"]
["V1 (up-regulated)","05/14/2013",23408906,"Porcu E","02/07/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23408906","A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.","Thyroid hormone levels"," (up-regulated) to 12,289 European ancestry females,  (up-regulated) to 9,019 European ancestry males,  (up-regulated) to 433 Old Order Amish females,  (up-regulated) to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males","NR","6p21.1",6,43904780,"VEGFA","- ",null,null,100132354,null,null,"rs11755845-T","rs11755845 ",0,11755845,"ncRNA",0,0.266,2e-10,9.69897000433601,"(TSH)",0.07,"[0.045-0.085] unit decrease","Illumina, Affymetrix [~2.5 Million] (Imputed)","N"]
["V1 (up-regulated)","05/14/2013",23408906,"Porcu E","02/07/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23408906","A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.","Thyroid hormone levels"," (up-regulated) to 12,289 European ancestry females,  (up-regulated) to 9,019 European ancestry males,  (up-regulated) to 433 Old Order Amish females,  (up-regulated) to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males","NR","6p21.1",6,43811762,"VEGFA",null,7422,221416,null,57.54,156.58,"rs9472138-T ","rs9472138",0,9472138,null,1,0.285,6e-12,11.2218487496163,"(TSH - Females)",0.09,"[0.065-0.115] unit decrease","Illumina, Affymetrix [~2.5 Million] (Imputed)","N"]
["V1 (up-regulated)","05/14/2013",23408906,"Porcu E","02/07/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23408906","A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.","Thyroid hormone levels"," (up-regulated) to 12,289 European ancestry females,  (up-regulated) to 9,019 European ancestry males,  (up-regulated) to 433 Old Order Amish females,  (up-regulated) to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males","NR","6p21.1",6,43811762,"VEGFA",null,7422,221416,null,57.54,156.58,"rs9472138-T ","rs9472138",0,9472138,null,1,0.285,5e-06,5.30102999566398,"(TSH - Males)",0.07,"[0.038-0.092] unit decrease","Illumina, Affymetrix [~2.5 Million] (Imputed)","N"]
["V1 (up-regulated)","05/14/2013",23408906,"Porcu E","02/07/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23408906","A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.","Thyroid hormone levels"," (up-regulated) to 12,289 European ancestry females,  (up-regulated) to 9,019 European ancestry males,  (up-regulated) to 433 Old Order Amish females,  (up-regulated) to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males","NR","6p21.1",6,43904780,"VEGFA","- ",null,null,100132354,null,null,"rs11755845-T","rs11755845 ",0,11755845,"ncRNA",0,0.266,3e-07,6.52287874528033,"(TSH - Males)",0.08,"[0.047-0.105] unit decrease","Illumina, Affymetrix [~2.5 Million] (Imputed)","N"]
["V1 (up-regulated)","05/09/2013",23377640,"GENDEP Investigators","02/01/2013","Am J Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23377640 ","Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.","Major depressive disorder"," (up-regulated) to 2,256 European ancestry cases","NR","5q14.3",5,87034352,"RASA1,CCNH",null,902,153396,null,325.5,456.67,"rs1673101-A","rs1673101",0,1673101,null,1,0.3312154,4e-06,5.39794000867203,"(% improvement - SSRI treated - 2 weeks)",0.19,"[0.11-0.27] unit decrease","Illumina & Affymetrix [1.2 million] (Imputed)","N"]
["V1 (up-regulated)","05/09/2013",23377640,"GENDEP Investigators","02/01/2013","Am J Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23377640 ","Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.","Major depressive disorder"," (up-regulated) to 2,256 European ancestry cases","NR","15q23",15,68597127,"PIAS1,CALML4,CLN6,FEM1B,ITGA11","- ",null,null,22801,null,null,"rs7174755-C","rs7174755",0,7174755,"intron",0,0.3690476,3e-07,6.52287874528033,"(% improvement - SSRI treated - 2 weeks)",0.2,"[0.13-0.28] unit decrease","Illumina & Affymetrix [1.2 million] (Imputed)","N"]
["V1 (up-regulated)","06/06/2013",23362303,"Wu JH","01/29/2013","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/23362303 ","Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.","Palmitic acid (16:0) plasma levels","8,961 European ancestry individuals",null,"20q13.13",20,48344311,"B4GALT5 ",null,9334,170550,null,13.89,1.82,"rs1980946-C ","rs1980946 ",0,1980946,null,1,"NR ",4e-06,5.39794000867203,null,0.3,"unit decrease ","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","06/06/2013",23362303,"Wu JH","01/29/2013","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/23362303 ","Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.","Palmitic acid (16:0) plasma levels","8,961 European ancestry individuals",null,"10q24.31",10,102075479,"PKD2L1, SCD ","- ",null,null,9033,null,null,"rs603424-A ","rs603424 ",0,603424,"intron",0,"NR ",2e-07,6.69897000433601,null,0.19,"unit increase ","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","06/06/2013",23362303,"Wu JH","01/29/2013","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/23362303 ","Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.","Palmitoleic acid (16:1n-7) plasma levels","8,961 European ancestry individuals",null,"10q24.31",10,102302457,"HIF1AN, SEC31B, NDUFB8, WNT8B, SCD ","- ",null,null,55662,null,null,"rs11190604-A ","rs11190604 ",0,11190604,"intron",0,0.782,6e-09,8.22184874961635,null,0.02,"unit decrease ","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","04/19/2013",23326517,"Holliday EG","01/11/2013","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23326517","Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.","Age-related macular degeneration","3,772 European ancestry cases, 16,033 European ancestry controls","264 Asian ancestry cases, 3,926 Asian ancestry controls","11q14.1",11,82821382,"PCF11, RAB30",null,1333,100127960,null,3.36,21.7,"rs4293143-?","rs4293143",0,4293143,null,1,0.31,8e-06,5.09691001300805,"(EA)",1.18,"[1.1-1.27] ","Illumina & Affymetrix [~2.5 million] Imputed","N"]
["V1 (up-regulated)","04/19/2013",23326517,"Holliday EG","01/11/2013","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23326517","Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.","Age-related macular degeneration","3,772 European ancestry cases, 16,033 European ancestry controls","264 Asian ancestry cases, 3,926 Asian ancestry controls","19q13.32",19,45392254,"PVRL2","- ",null,null,5819,null,null,"rs6857-?","rs6857",0,6857,"UTR-3",0,0.85,1e-06,5.99999999999999,"(EA)",1.23,"[1.14-1.35] ","Illumina & Affymetrix [~2.5 million] Imputed","N"]
["V1 (up-regulated)","04/19/2013",23326517,"Holliday EG","01/11/2013","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23326517","Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.","Age-related macular degeneration","3,772 European ancestry cases, 16,033 European ancestry controls","264 Asian ancestry cases, 3,926 Asian ancestry controls","19q13.32",19,45392254,"PVRL2,APOE,TOMM40","- ",null,null,5819,null,null,"rs6857-?","rs6857",0,6857,"UTR-3",0,0.85,1e-06,5.99999999999999,null,1.23,"[1.14-1.35] ","Illumina & Affymetrix [~2.5 million] Imputed","N"]
["V1 (up-regulated)","04/17/2013",23297363,"Cordell HJ","01/07/2013","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23297363 ","Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot.","Tetralogy of Fallot","835 European ancestry cases, 5,159 European ancestry controls","798 European ancestry cases and 2,931 European ancestry controls","12q24.12",12,112072424,"PTPN11",null,6311,8315,null,34.94,7.53,"rs11065987-G","rs11065987",0,11065987,null,1,0.418,8e-11,10.096910013008,null,1.34,"[1.208-1.496] ","Illumina [516,131]","N"]
["V1 (up-regulated)","03/28/2013",23291589,"Lu Y","01/06/2013","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23291589 ","Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.","Corneal structure","13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals","NR","9q31.3",9,113662681,"LPAR1","- ",null,null,1902,null,null,"rs1007000-T","rs1007000",0,1007000,"intron",0,0.22,5e-12,11.3010299956639,null,0.07,"[0.031-0.109] unit increase","Illumina & Affymetrix [~1 Million] (Imputed)","N"]
["V1 (up-regulated)","03/28/2013",23291589,"Lu Y","01/06/2013","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23291589 ","Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.","Corneal structure","13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals","NR","3q26.31",3,171995605,"FNDC3B","- ",null,null,64778,null,null,"rs4894535 -T","rs4894535",0,4894535,"intron",0,0.17,5e-12,11.3010299956639,null,0.1,"[0.061-0.139] unit decrease","Illumina & Affymetrix [~1 Million] (Imputed)","N"]
["V1 (up-regulated)","03/15/2013",23263486,"Kottgen A","12/23/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263486","Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.","Urate levels","49,825 European ancestry men, 60,522 European ancestry women"," (up-regulated) to 32,813 European ancestry individuals","6p21.1",6,43804571,"VEGFA",null,7422,221416,null,50.35,163.77,"rs729761-T","rs729761",0,729761,null,1,0.3,8e-16,15.096910013008,null,0.05,"[0.036-0.058] mg/dl decrease","Affymetrix, Illumina, Perlegen [2,450,547] (imputed)","N"]
["V1 (up-regulated)","03/15/2013",23263486,"Kottgen A","12/23/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263486","Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.","Urate levels","49,825 European ancestry men, 60,522 European ancestry women"," (up-regulated) to 32,813 European ancestry individuals","12q24.12",12,112007756,"ATXN2, PTPN11","- ",null,null,6311,null,null,"rs653178-T","rs653178",0,653178,"intron",0,0.51,7e-12,11.1549019599857,null,0.04,"[0.025-0.045] mg/dl decrease","Affymetrix, Illumina, Perlegen [2,450,547] (imputed)","N"]
["V1 (up-regulated)","02/19/2013",23266556,"Peters U","12/21/2012","Gastroenterology","http://www.ncbi.nlm.nih.gov/pubmed/23266556","Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.","Colorectal cancer","12,696 European ancestry colorectal tumor cases, and 15,113 European ancestry controls","958 European ancestry colorectal tumor cases,  (up-regulated) to 2,098 East Asian ancestry colorectal tumor cases, 909 European ancestry controls,  (up-regulated) to 5,749 East Asian ancestry controls","8q24.21",8,128413305,"MYC",null,401475,5462,null,312.53,14.55,"rs6983267-G","rs6983267",0,6983267,null,1,0.5,1e-11,11,null,1.13,"[1.09-1.18] ","Illumina & Affymetrix [2,708,280] imputed","N"]
["V1 (up-regulated)","02/27/2013",23284291,"Hancock DB","12/20/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23284291 ","Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.","Pulmonary function (interaction)","50,047 European ancestry individuals","NR","16q21",16,58075282,"MMP15","- ",null,null,4324,null,null,"rs12447804-?","rs12447804",0,12447804,"intron",0,"NR",4e-08,7.39794000867203,"(FEV1/FVC, Ever-smoking)","NR","NR","NR [~2.5 Million] (imputed)","N"]
["V1 (up-regulated)","12/16/2012",23001997,"Hou S","12/06/2012","Arthritis Rheum","http://www.ncbi.nlm.nih.gov/pubmed/23001997","Identification of a susceptibility locus in STAT4 for Beh&#x000e7;et's disease in Han Chinese in a genome-wide association study.","Behcet's disease","147 Han Chinese cases, 951 Han Chinese controls","554 Han Chinese cases, 1,159 Han Chinese controls","6p21.33",6,31336418,"MICA, MICB, DHFRP2",null,729816,100462812,null,1.68,9.08,"rs9266406-?","rs9266406",0,9266406,null,1,0.4,2e-10,9.69897000433601,null,2.29,"[1.77-2.95] ","Affyemtrix [661,736]","N"]
["V1 (up-regulated)","03/19/2013",23222517,"van der Harst P","12/05/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23222517","Seventy-five genetic loci influencing the human red blood cell.","Red blood cell traits","62,553 European ancestry individuals, 9,308 South Asian ancestry individuals","63,506 European ancestry individuals","22q12.3",22,32880585,"FBXO7","- ",null,null,25793,null,null,"rs5749446-T","rs5749446",0,5749446,"intron",0,0.62,3e-13,12.5228787452803,"(EA, MCH)",0.01,"[-0.00084-0.01484] unit increase","Illumina, Affymetrix & Perlegen [2,711,806] imputed","N"]
["V1 (up-regulated)","03/19/2013",23222517,"van der Harst P","12/05/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23222517","Seventy-five genetic loci influencing the human red blood cell.","Red blood cell traits","62,553 European ancestry individuals, 9,308 South Asian ancestry individuals","63,506 European ancestry individuals","3q29",3,195834357,"TFRC",null,100147766,131540,null,34.61,89.97,"rs11717368-C","rs11717368",0,11717368,null,1,0.52,7e-19,18.1549019599857,"(EA, MCH)",0.01,"[0.00016-0.01584] unit increase","Illumina, Affymetrix & Perlegen [2,711,806] imputed","N"]
["V1 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","1q23.1",1,159002222,"IFI16, MNDA, AIM2","- ",null,null,3428,null,null,"rs861318-A","rs861318",0,861318,"intron",0,0.12,1e-06,5.99999999999999,"(Diet carbohydrate )",0.04,"[NR]  g/d increase","Illumina [899,892]","N"]
["V1 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","11q14.1",11,82876270,"PCF11","- ",null,null,51585,null,null,"rs1943345-C","rs1943345",0,1943345,"intron",0,0.239,7e-06,5.15490195998574,"(Moderate activity )",0.03,"[NR]  %awake time increase","Illumina [899,892]","N"]
["V1 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","17q22",17,53519844,"MMD",null,23531,55273,null,20.5,277.14,"rs11653011-G","rs11653011",0,11653011,null,1,0.473,3e-06,5.52287874528033,"(Urinary free dopamine: creatinine)",0.04,"[NR]  unit increase","Illumina [899,892]","N"]
["V1 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","11q23.3",11,116647607,"ZNF259, APOA5",null,84811,8882,null,3.89,1.67,"rs2160669-G","rs2160669",0,2160669,null,1,0.168,9e-06,5.04575749056067,"(TG/HDLC )",0.03,"[NR] mmol/L increase","Illumina [899,892]","N"]
["V1 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","11q23.3",11,116657561,"ZNF259, APOA5","- ",null,null,8882,null,null,"rs3741298-G","rs3741298",0,3741298,"intron",0,0.48,3e-08,7.52287874528033,"(TG )",0.04,"[NR]  mg/dL increase","Illumina [899,892]","N"]
["V1 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","8q24.13",8,126534671,"TRIB1",null,10221,100130231,null,84.03,400.1,"rs921720-A","rs921720",0,921720,null,1,0.414,3e-06,5.52287874528033,"(Gestational age )",0.05,"[NR]  wk increase","Illumina [899,892]","N"]
["V1 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","2q37.1",2,231035745,"SP110","- ",null,null,3431,null,null,"rs13010639-A","rs13010639",0,13010639,"intron",0,0.085,6e-06,5.22184874961635,"(BMR RQ)",0.04,"[NR]  unit increase","Illumina [899,892]","N"]
["V1 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","4p15.33",4,12500221,"RAB28",null,9957,9364,null,1069.68,869.13,"rs62295889-G","rs62295889",0,62295889,null,1,0.026,6e-06,5.22184874961635,"(Urinary free epinephrine )",0.03,"[NR]  nmol/d increase","Illumina [899,892]","N"]
["V1 (up-regulated)","02/14/2013",23192594,"Velez Edwards DR","11/29/2012","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23192594 ","Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.","Body mass index (interaction)","8,203 African American women, 3,484 Hispanic ancestry women","NR","14q32.13",14,95410529,"RPL15P2, DICER1",null,326279,23405,null,142.67,142.04,"rs10133840-C","rs10133840",0,10133840,null,1,0.14,1e-06,5.99999999999999,"(Hispanic, Dietary energy)",0.01,"[0.005-0.01] unit decrease","Affymetrix [706,791]","N"]
["V1 (up-regulated)","02/14/2013",23192594,"Velez Edwards DR","11/29/2012","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23192594 ","Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.","Body mass index (interaction)","8,203 African American women, 3,484 Hispanic ancestry women","NR","14q32.13",14,95410529,"RPL15P2, DICER1",null,326279,23405,null,142.67,142.04,"rs10133840-C","rs10133840",0,10133840,null,1,"NR",4e-07,6.39794000867203,"(Dietary energy)",0.01,"[NR] unit decrease","Affymetrix [706,791]","N"]
["V1 (up-regulated)","02/14/2013",23192594,"Velez Edwards DR","11/29/2012","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23192594 ","Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.","Waist-to-hip circumference ratio (interaction)","8,203 African American women, 3,484 Hispanic ancestry women","NR","19q13.32",19,45326768,"BCAM, PVRL2",null,4059,5819,null,2.09,22.63,"rs1871045-T","rs1871045",0,1871045,null,1,0.39,4e-06,5.39794000867203,"(Hispanic, Smoking, Years)",0.52,"[0.30-0.74] unit increase","Affymetrix [706,791]","N"]
["V1 (up-regulated)","01/29/2013",23149075,"Aslibekyan S","11/10/2012","Nutr Metab Cardiovasc Dis","http://www.ncbi.nlm.nih.gov/pubmed/23149075","Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network.","Response to fenofibrate (adiponectin levels)","793 European ancestry individuals","NA","12q24.13",12,113607502,"DDX54, TPCN1, SLC24A6, OAS1, OAS2, OAS3","- ",null,null,79039,null,null,"rs2384207-?","rs2384207",0,2384207,"intron",0,"NR",5e-08,7.30102999566398,"(Response)",0.06,"[0.040-0.080] ng/dL increase","Affymterix [2,543,887] (imputed)","N"]
["V1 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","14q24.3",14,75701221,"FOS,MLH3",null,10972,2353,null,57.87,44.26,"rs4899554-C","rs4899554",0,4899554,null,1,0.819,3e-08,7.52287874528033,null,1.08,"[1.042-1.125] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V1 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","22q12.2",22,30486826,"LIF,OSM,MTMR3","- ",null,null,150280,null,null,"rs2412970-G","rs2412970",0,2412970,"intron",0,0.457,3e-14,13.5228787452803,null,1.08,"[1.049-1.111] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V1 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","22q13.1",22,39659773,"ATF4,TAB1,APOBEC3G",null,5155,116938,null,18.82,50.05,"rs2413583-C","rs2413583",0,2413583,null,1,0.833,4e-33,32.397940008672,null,1.21,"[1.163-1.257] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V1 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","4q13.3",4,74857708,"CXCL5,CXCL1,CXCL3,IL8,CXCL6,PF4,CXCL2,PF4V1",null,5473,6374,null,3.8,3.65,"rs2472649-G","rs2472649",0,2472649,null,1,0.824,3e-08,7.52287874528033,null,1.1,"[1.046-1.146] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V1 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","8q24.13",8,126534671,"TRIB1",null,10221,100130231,null,84.03,400.1,"rs921720-G","rs921720",0,921720,null,1,0.609,8e-20,19.096910013008,null,1.08,"[1.049-1.113] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V1 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","9q22.31",9,93928416,"NFIL3",null,6850,549,null,267.57,47.68,"rs4743820-T","rs4743820",0,4743820,null,1,0.702,4e-09,8.39794000867203,null,1.06,"[1.023-1.089] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V1 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","10p15.1",10,6081230,"IL2RA,IL15RA","- ",null,null,3559,null,null,"rs12722515-C","rs12722515",0,12722515,"intron",0,0.849,4e-10,9.39794000867203,null,1.1,"[1.06-1.147] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V1 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","1q32.1",1,206939904,"IL10,IL20,IL19,IL24,PIGR,MAPKAPK2,FAIM3,RASSF5",null,9261,3586,null,32.27,1.04,"rs3024505-A","rs3024505",0,3024505,null,1,0.16,7e-42,41.1549019599857,null,1.21,"[1.163-1.254] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V1 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","11q13.1",11,65656564,"RELA,FOSL1,CTSW,SNX32","- ",null,null,"9158;11007",null,null,"rs2231884-T","rs2231884",0,2231884,"nearGene-5;nearGene-5",0,0.157,3e-10,9.52287874528033,null,1.08,"[1.044-1.122] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V1 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","19q13.11",19,33731551,"CEBPG",null,56301,1050,null,14.8,59.29,"rs17694108-A","rs17694108",0,17694108,null,1,0.282,6e-15,14.2218487496163,null,1.1,"[1.065-1.135] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V1 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","20q13.13",20,48955424,"CEBPB",null,1051,170504,null,146.2,140.83,"rs913678-T","rs913678",0,913678,null,1,0.662,5e-08,7.30102999566398,null,1.06,"[1.024-1.088] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V1 (up-regulated)","12/11/2012",23028342,"Sandholm N","09/20/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23028342","New susceptibility loci associated with kidney disease in type 1 diabetes.","Type 1 diabetes nephropathy"," (up-regulated) to 2,916 European ancestry Type 1 Diabetes cases with nephropathy, 3,315 European ancestry Type 1 Diabetes cases without nephropathy"," (up-regulated) to 1,493 European ancestry Type 1 Diabetes cases with nephropathy, 3,191 European ancestry Type 1 Diabetes cases without nephropathy","12q24.31",12,120974510,"RNF10, COQ5","- ",null,null,9921,null,null,"rs614226-C","rs614226",0,614226,"intron",0,0.83,2e-06,5.69897000433601,"(ESRD)",1.35,"[1.19-1.54] ","Affymetrix & Illumina [~2.5 Million] (imputed)","N"]
["V1 (up-regulated)","11/28/2012",22990020,"Huang J","09/18/2012","Blood","http://www.ncbi.nlm.nih.gov/pubmed/22990020","Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.","Plasminogen activator inhibitor type 1 levels (PAI-1)","19,599 European ancestry individuals","10,764 European ancestry individuals","7q22.1",7,100512119,"ACHE, SLC12A9, TRIP6, SRRT, UFSP1, EPHB4, MUC3",null,43,100271241,null,18.58,13.84,"rs6976053-?","rs6976053",0,6976053,null,1,"NR",6e-13,12.2218487496163,null,0.05,"[NR] unit increase","Affymetrix & Illumina [2,445,683] (imputed)","N"]
["V1 (up-regulated)","11/30/2012",22976474,"Siddiq A","09/13/2012","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/22976474","A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11.","Breast cancer","3,666 European ancestry cases, 28,864 European ancestry controls, 1,004 African American cases, 2,744 African American controls","562 European ancestry cases, 6,410 European ancestry controls, 84 Japanese ancestry cases, 830 Japanese ancestry controls, 300 Hispanic/Latin American cases, 1,164 Hispanic/Latin American controls","20q11.22",20,32588095,"RALY, EIF2S2, ASIP","- ",null,null,22913,null,null,"rs2284378-T","rs2284378",0,2284378,"intron",0,0.31,1e-08,8,null,1.16,"[1.10-1.22] ","Illumina [2,608,509] (imputed)","N"]
["V1 (up-regulated)","11/20/2012",22959728,"Ahmeti KB","09/05/2012","Neurobiol Aging","http://www.ncbi.nlm.nih.gov/pubmed/22959728","Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.","Amyotrophic lateral sclerosis (age of onset)","4,243 European ancestry cases","NR","7q31.1",7,112094743,"IFRD1","- ",null,null,3475,null,null,"rs6956741-G","rs6956741",0,6956741,"intron",0,0.06,2e-06,5.69897000433601,"(Meta)","NR","NR","Illumina [254,145]","N"]
["V1 (up-regulated)","11/05/2012",22952603,"Hart AB","08/28/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/22952603","Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).","Response to amphetamines","1 American Indian ancestry individual, 18 African American/Afro-Caribbean ancestry individuals, 10 East Asian and South Asian ancestry individuals, 325 European ancestry individuals, 17 Latin American ancestry individuals, 6 other ancestry individuals, 4 individuals","NR","17p12",17,12047544,"MAP2K4","- ",null,null,6416,null,null,"rs1870584-?","rs1870584",0,1870584,"nearGene-3",0,"NR",5e-06,5.30102999566398,"(SF2)","NR","NR","Affymetrix [5,476,100] (imputed)","N"]
["V1 (up-regulated)","11/02/2012",22939635,"Reiner AP","08/28/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/22939635","Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.","C-reactive protein","8,280 African American women, 3,548 Hispanic/Latin American ancestry women","3,787 African American women, 3,548 Hispanic/Latin American ancestry women, 5,656 European ancestry individuals","1q23.2",1,159649700,"CRP, APCS, DARC, FCER1A, DUSP23, OR10J1, OR10J5, OR10J3, OLFML2B, IFI16, FCRL6",null,401973,171422,null,80.69,25.04,"rs16827466-T","rs16827466",1,10494326,null,1,0.178,4e-73,72.397940008672,"(AA Women)",0.42,"[0.37-0.46] unit increase","Affymetrix [ (up-regulated) to 2,203,609] (imputed)","N"]
["V1 (up-regulated)","11/02/2012",22939635,"Reiner AP","08/28/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/22939635","Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.","C-reactive protein","8,280 African American women, 3,548 Hispanic/Latin American ancestry women","3,787 African American women, 3,548 Hispanic/Latin American ancestry women, 5,656 European ancestry individuals","1q23.2",1,159698549,"CRP, APCS, DARC, FCER1A, DUSP23, OR10J1, OR10J5, OR10J3, OLFML2B, IFI16, FCRL6",null,1401,646446,null,14.17,30.39,"rs7553007-T","rs7553007",0,7553007,null,1,0.228,1e-37,37,"(AA women)",0.27,"[0.23-0.31] (unit decrease)","Affymetrix [ (up-regulated) to 2,203,609] (imputed)","N"]
["V1 (up-regulated)","11/02/2012",22939635,"Reiner AP","08/28/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/22939635","Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.","C-reactive protein","8,280 African American women, 3,548 Hispanic/Latin American ancestry women","3,787 African American women, 3,548 Hispanic/Latin American ancestry women, 5,656 European ancestry individuals","1q23.2",1,159692573,"CRP, APCS, DARC, FCER1A, DUSP23, OR10J1, OR10J5, OR10J3, OLFML2B, IFI16, FCRL6",null,1401,646446,null,8.19,36.36,"rs2808634-T","rs2808634",0,2808634,null,1,0.156,3e-10,9.52287874528033,"(AA women)",0.15,"[0.11-0.20] (unit decrease)","Affymetrix [ (up-regulated) to 2,203,609] (imputed)","N"]
["V1 (up-regulated)","11/21/2012",22916037,"Inouye M","08/16/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22916037","Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.","Metabolite levels","6,608 European ancestry individuals","NR","15q22.2",15,59487930,"MYO1E, CCNB2, RNF111","- ",null,null,4643,null,null,"rs2306786-?","rs2306786",0,2306786,"intron",0,0.17,1e-10,10,null,"NR","NR","Illumina [~2 million] (imputed)","N"]
["V1 (up-regulated)","09/26/2012",22837378,"Wilk JB","07/26/2012","Am J Respir Crit Care Med","http://www.ncbi.nlm.nih.gov/pubmed/22837378","Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.","Airflow obstruction "," (up-regulated) to 3,368 European ancestry cases,  (up-regulated) to 29,507 European ancestry controls","331 European ancestry cases, 2,550 European ancestry controls","1p32.2",1,56359813,"PPAP2B",null,645538,127406,null,525.37,313.33,"rs6684428-A","rs6684428",0,6684428,null,1,0.16,5e-07,6.30102999566398,"(Smoker)",1.23,"[NR] ","Affymetrix & Illumina [ (up-regulated) to ~2,500,000] (imputed)","N"]
["V1 (up-regulated)","09/27/2012",22808956,"Lyons PA","07/19/2012","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/22808956","Genetically distinct subsets within ANCA-associated vasculitis.","Antineutrophil cytoplasmic antibody-associated vasculitis ","914 European ancestry cases, 5,259 European ancestry controls","1,454 European ancestry cases, 1,666 European ancestry controls","Xq27.3",23,147042774,"FMR1, FMR1NB",null,2332,158521,null,10.13,20.08,"rs5904818-?","rs5904818",0,5904818,null,1,"NR",2e-08,7.69897000433601,null,"NR","NR","Affymetrix [NR]","N"]
["V1 (up-regulated)","09/14/2012",22780124,"Lind PA","07/11/2012","Addict Biol","http://www.ncbi.nlm.nih.gov/pubmed/22780124","Genome-wide association study of a quantitative disordered gambling trait.","Gambling","1,312 twins from 894 families","NR","16q13",16,56725173,"MT1X, MT11P, MT1H, MT1G, MT1F, MT1B, N (up-regulated)93",null,100131777,9688,null,2.96,38.84,"rs8064100-A","rs8064100",0,8064100,null,1,0.582,3e-06,5.52287874528033,null,0.15,"[0.087-0.209] unit decrease","Illumina [2,373,249] (imputed)","N"]
["V1 (up-regulated)","11/22/2012",22699663,"Divaris K","07/01/2012","J Dent Res","http://www.ncbi.nlm.nih.gov/pubmed/22699663","Genome-wide association study of periodontal pathogen colonization.","Periodontal microbiota","1,020 European ancestry individuals","NR","14q24.3",14,75814028,"FOS, JDP2",null,2353,122953,null,65.09,80.48,"rs11621969-T","rs11621969",0,11621969,null,1,0.789,9e-07,6.04575749056067,"(A. actino)",2.46,"[1.68-3.62] ","Affymetrix [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","08/14/2012",22726844,"Kim JW","06/20/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/22726844","A common variant in SLC8A1 is associated with the duration of the electrocardiographic QT interval.","QT interval","6,805 Korean ancestry individuals","4,686 Korean ancestry individuals, 2,687 Japanese ancestry individuals","16q21",16,58566304,"NDRG4, CNOT1","- ",null,null,23019,null,null,"rs37060-?","rs37060",0,37060,"intron",0,"NR",1e-07,7,null,1.52,"[0.957-2.084] ms increase","Affymetrix [352,228]","N"]
["V1 (up-regulated)","08/07/2012",22610502,"Kennedy RB","05/19/2012","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/22610502","Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.","Immune reponse to smallpox (secreted IFN-alpha)"," (up-regulated) to 512 European ancestry individuals,  (up-regulated) to 199 African American individuals","NR","9q33.2",9,123951917,"RAB14","- ",null,null,51552,null,null,"rs9408928-G","rs9408928",0,9408928,"intron",0,"NR",4e-09,8.39794000867203,"(AA)","NR","NR","Illumina [NR]","N"]
["V1 (up-regulated)","08/07/2012",22610502,"Kennedy RB","05/19/2012","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/22610502","Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.","Immune reponse to smallpox (secreted IL-12p40)"," (up-regulated) to 512 European ancestry individuals,  (up-regulated) to 199 African American individuals","NR","17p12",17,15826021,"ADORA2B",null,4213,136,null,133,22.21,"rs859267-C","rs859267",0,859267,null,1,"NR",3e-07,6.52287874528033,"(AA)","NR","NR","Illumina [NR]","N"]
["V1 (up-regulated)","08/17/2012",22589738,"Fox CS","05/10/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22589738","Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.","Visceral fat","5,560 European ancestry women and 4,997 European ancestry men","NR","2p14",2,65027624,"SERTAD2",null,730187,100133170,null,134.37,159.52,"rs11683197-T","rs11683197",0,11683197,null,1,0.72,5e-06,5.30102999566398,"(overall)","NR","NR","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V1 (up-regulated)","08/14/2012",22566634,"Benjamin DJ","05/07/2012","Proc Natl Acad Sci U S A","http://www.ncbi.nlm.nih.gov/pubmed/22566634","The genetic architecture of economic and political preferences.","Economic and political preferences (immigration/crime)","9,617 individuals","NR","6q16.3",6,100957344,"ASCC3","- ",null,null,10973,null,null,"rs240768-T","rs240768",0,240768,"missense",0,"NR",2e-06,5.69897000433601,null,0.27,"[0.16-0.38] unit increase","Illumina [628,922]","N"]
["V1 (up-regulated)","07/04/2012",22542470,"Ovsyannikova IG","04/25/2012","Vaccine","http://www.ncbi.nlm.nih.gov/pubmed/22542470","Genome-wide association study of antibody response to smallpox vaccine.","Immune response to smallpox vaccine (IL-6)","217 African American ancestry individuals, 580 European ancestry individuals, 217 Hispanic ancestry individuals","NR","12q24.33",12,133345809,"ANKLE2, GOLGA3","- ",null,null,2802,null,null,"rs12282-?","rs12282",0,12282,"UTR-3",0,"NR",3e-07,6.52287874528033,"(Hispanic)","NR","NR","Illumina [NR]","N"]
["V1 (up-regulated)","04/11/2013",22504420,"Estrada K","04/15/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22504420","Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.","Bone mineral density"," (up-regulated) to 32,961 European and East Asian ancestry individuals"," (up-regulated) to 50,933 European and East Asian ancestry individuals","9q34.11",9,133478827,"FUBP3","- ",null,null,8939,null,null,"rs7851693-C","rs7851693",0,7851693,"intron",0,0.64,3e-22,21.5228787452803,"(FNBMD)",0.05,"[NR] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","04/11/2013",22504420,"Estrada K","04/15/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22504420","Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.","Bone mineral density"," (up-regulated) to 32,961 European and East Asian ancestry individuals"," (up-regulated) to 50,933 European and East Asian ancestry individuals","2q14.2",2,119038598,"INSIG2",null,51141,2019,null,171,561.15,"rs1878526-A","rs1878526",0,1878526,null,1,0.22,1e-10,10,"(LSBMD)",0.04,"[NR] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","04/11/2013",22504420,"Estrada K","04/15/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22504420","Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.","Bone mineral density"," (up-regulated) to 32,961 European and East Asian ancestry individuals"," (up-regulated) to 50,933 European and East Asian ancestry individuals","20p12.2",20,10639988,"JAG1","- ",null,null,182,null,null,"rs3790160-T","rs3790160",0,3790160,"intron",0,0.5,3e-19,18.5228787452803,"(LSBMD)",0.05,"[NR] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","05/25/2012",22493691,"Eriksson N","04/06/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/22493691","Novel associations for hypothyroidism include known autoimmune risk loci.","Hypothyroidism","3,736 European ancestry cases, 35,546 European ancestry controls","NR","12q24.12",12,111884608,"SH2B3, ATXN2, LOC100101246, BRAP, NAA25, C12orf51, PTPN11","- ",null,null,10019,null,null,"rs3184504-T","rs3184504",0,3184504,"missense",0,0.502,3e-12,11.5228787452803,null,1.2,"[1.14-1.27] ","Illumina [870,065]","N"]
["V1 (up-regulated)","05/11/2012",22472876,"Major Depressive Disorder Working Gro (up-regulated) of the Psychiatric GWAS Consortium","04/03/2012","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22472876","A mega-analysis of genome-wide association studies for major depressive disorder.","Major depressive disorder","9,240 European ancestry cases, 9,519 European ancestry controls","6,783 European ancestry cases, 50,695 European ancestry controls","16q24.2",16,87461969,"FBXO31,MAP1LC3B,ZCCHC14","- ",null,null,23174,null,null,"rs9646303-?","rs9646303",0,9646303,"intron",0,"NR",5e-06,5.30102999566398,null,"NR","NR","Affymetrix, Illumina & Perlegen [~1.2 million](imputed)","N"]
["V1 (up-regulated)","05/10/2012",22479202,"Dastani Z","03/29/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22479202","Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.","Adiponectin levels","29,347 European ancestry individuals","10,536 European ancestry individuals","6p21.1",6,43757896,"VEGFA",null,7422,221416,null,3.67,210.44,"rs998584-C","rs998584",0,998584,null,1,0.5,3e-08,7.52287874528033,null,0.03,"[0.020-0.040] unit increase","Affymetrix & Illumina [NR](imputed)","N"]
["V1 (up-regulated)","05/10/2012",22479202,"Dastani Z","03/29/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22479202","Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.","Adiponectin levels","29,347 European ancestry individuals","10,536 European ancestry individuals","8q24.13",8,126481475,"TRIB1",null,10221,100130231,null,30.83,453.29,"rs2980879-T","rs2980879",0,2980879,null,1,0.7,7e-09,8.15490195998574,null,0.03,"[0.020-0.040] unit increase","Affymetrix & Illumina [NR](imputed)","N"]
["V1 (up-regulated)","05/10/2012",22479202,"Dastani Z","03/29/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22479202","Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.","Adiponectin levels","29,347 European ancestry individuals, 4,232 African American ancestry individuals, 1,776 Filipino  individuals",null,"8q24.13",8,126481475,"TRIB1",null,10221,100130231,null,30.83,453.29,"rs2980879-T","rs2980879",0,2980879,null,1,0.69,1e-09,8.99999999999999,null,0.03,"[0.022-0.038] unit increase","Affymetrix & Illumina [NR] (imputed)","N"]
["V1 (up-regulated)","06/18/2012",22437554,"Major JM","03/21/2012","J Nutr","http://www.ncbi.nlm.nih.gov/pubmed/22437554","Genome-wide association study identifies three common variants associated with serologic response to vitamin E s (up-regulated)plementation in men.","Response to Vitamin E s (up-regulated)plementation","2,112 European ancestry individuals","NR","11q23.3",11,116648917,"BUD13,ZNF259","- ",null,null,8882,null,null,"rs964184-G","rs964184",0,964184,"nearGene-3",0,0.15,4e-07,6.39794000867203,"(change in alpha-TOH)",0.88,"[0.55-1.21] unit increase","Illumina [549,989]","N"]
["V1 (up-regulated)","06/18/2012",22437554,"Major JM","03/21/2012","J Nutr","http://www.ncbi.nlm.nih.gov/pubmed/22437554","Genome-wide association study identifies three common variants associated with serologic response to vitamin E s (up-regulated)plementation in men.","Response to Vitamin E s (up-regulated)plementation","2,112 European ancestry individuals","NR","11q23.3",11,116648917,"BUD13, ZNF259, APOA5, LOC100128347, SIK3","- ",null,null,8882,null,null,"rs964184-G","rs964184",0,964184,"nearGene-3",0,0.15,3e-12,11.5228787452803,"(alpha-TOH)",0.07,"[0.050-0.090] mg/L increase","Illumina [549,989]","N"]
["V1 (up-regulated)","04/03/2012",22399527,"Kristiansson K","03/07/2012","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/22399527","Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.","Metabolic syndrome","2,637 European ancestry cases, 7,927 European ancestry controls","NR","11q23.3",11,116648917,"ZNF259","- ",null,null,8882,null,null,"rs964184-G","rs964184",0,964184,"nearGene-3",0,0.15,3e-31,30.5228787452803,"(TG)",0.23,"[NR] mmol/l increase","Illumina [1,257,079] (imputed)","N"]
["V1 (up-regulated)","03/27/2012",22359512,"Demirkan A","02/16/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22359512","Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.","Phospholipid levels (plasma)","4,034 European ancestry individuals","NR","12q23.1",12,96858362,"CDK17",null,5128,390352,null,64,436.51,"rs12423247-?","rs12423247",0,12423247,null,1,"NR",3e-08,7.52287874528033,"(levels)",0.8,"[NR] % increase","Illumina [NR] (imputed)","N"]
["V1 (up-regulated)","03/08/2012",22319020,"Davies RW","02/07/2012","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/22319020","A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.","Coronary heart disease","7,123 European ancestry cases, 6,826 European ancestry controls","5,211 European ancestry cases, 5,821 European ancestry controls","6p21.1",6,43758873,"VEGFA",null,7422,221416,null,4.65,209.46,"rs6905288-T","rs6905288",0,6905288,null,1,"NR",7e-08,7.15490195998574,null,1.23,"[NR] ","Affymetrix [~5 million] (imputed)","N"]
["V1 (up-regulated)","01/18/2012",22158540,"Wu C","12/11/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22158540","Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.","Pancreatic cancer","981 Chinese ancestry cases, 1,991 Chinese ancestry contorls.","2,603 Chinese ancestry cases, 2,877 Chinese ancestry controls.","3q29",3,195751630,"TFRC",null,255812,7037,null,34.48,24.53,"rs4927850-A","rs4927850",0,4927850,null,1,"NR",2e-07,6.69897000433601,null,1.24,"[1.14-1.35] ","Affymetrix [666,141]","N"]
["V1 (up-regulated)","01/06/2012",22159054,"Logue MW","12/01/2011","Arch Neurol","http://www.ncbi.nlm.nih.gov/pubmed/22159054","A comprehensive genetic association study of Alzheimer disease in African Americans.","Alzheimer's disease","513 African American ancestry cases, 496 African American ancestry controls",null,"19q13.32",19,45382034,"PVRL2","- ",null,null,5819,null,null,"rs6859-A","rs6859",0,6859,"intron",0,"NR",5e-07,6.30102999566398,null,1.58,"[NR] ","Illumina [2,505,093] (imputed)","N"]
["V1 (up-regulated)","11/16/2012",22139419,"Gieger C","11/30/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/22139419","New gene functions in megakaryopoiesis and platelet formation.","Mean platelet volume","18,600 European ancestry individuals"," (up-regulated) to 18,838 European ancestry individuals","12q13.3",12,57055291,"PTGES3,BAZ2A",null,26789,10728,null,16.41,1.83,"rs2950390-C","rs2950390",0,2950390,null,1,"NR",7e-14,13.1549019599857,null,0.01,"[0.006-0.01] ln(fl) increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","11/16/2012",22139419,"Gieger C","11/30/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/22139419","New gene functions in megakaryopoiesis and platelet formation.","Platelet counts","48,666 individuals of European ancestry"," (up-regulated) to 18,838 individuals of European ancestry","12q24.13",12,113100994,"RPH3A,PTPN11",null,5781,100302227,null,153.28,31.85,"rs17824620-C","rs17824620",0,17824620,null,1,"NR",1e-08,8,null,2.46,"[1.62-3.3] 10^9/l increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","11/16/2012",22139419,"Gieger C","11/30/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/22139419","New gene functions in megakaryopoiesis and platelet formation.","Platelet counts","48,666 individuals of European ancestry"," (up-regulated) to 18,838 individuals of European ancestry","12q13.3",12,57023284,"PTGES3,BAZ2A","- ",null,null,11176,null,null,"rs941207-G","rs941207",0,941207,"intron",0,"NR",2e-10,9.69897000433601,null,2.75,"[1.91-3.6] 10^9/l increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","12/14/2011",22087292,"Sun L","11/07/2011","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/22087292","Bivariate genome-wide association analyses of femoral neck bone geometry and appendicular lean mass.","Femoral neck bone geometry","1,627 Han Chinese individuals","2,286 European ancestry individuals","2p12",2,75074967,"HK2","- ",null,null,3099,null,null,"rs681900-?","rs681900",0,681900,"intron",0,"NR",3e-06,5.52287874528033,"(ALM-BR)","NR","NR","Affymetrix [689,368]","N"]
["V1 (up-regulated)","11/19/2011",22005931,"Kamboh MI","10/18/2011","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22005931","Genome-wide association analysis of age-at-onset in Alzheimer's disease.","Alzheimer's disease (age of onset)","2,222 cases","NR","19q13.32",19,45392254,"PVRL2","- ",null,null,5819,null,null,"rs6857-?","rs6857",0,6857,"UTR-3",0,"NR",2e-10,9.69897000433601,null,"NR","NR","Illumina [2,543,888] (imputed)","N"]
["V1 (up-regulated)","11/18/2011",22001757,"Chambers JC","10/16/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22001757","Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.","Liver enzyme levels (alanine transaminase)"," (up-regulated) to 52,350 European ancestry individuals,  (up-regulated) to 8,739 Indian Asian individuals","NR","8q24.13",8,126482077,"TRIB1",null,10221,100130231,null,31.43,452.69,"rs2954021-A","rs2954021",0,2954021,null,1,0.5,5e-09,8.30102999566398,null,1.6,"[0.60-2.60] % increase","Affymetrix, Illumina, and Perlegen [~2.6 million] (imputed)","N"]
["V1 (up-regulated)","11/18/2011",22001757,"Chambers JC","10/16/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22001757","Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.","Liver enzyme levels (alkaline phosphatase)"," (up-regulated) to 52,350 European ancestry individuals,  (up-regulated) to 8,739 Indian Asian individuals","NR","8q24.13",8,126482077,"TRIB1",null,10221,100130231,null,31.43,452.69,"rs2954021-A","rs2954021",0,2954021,null,1,0.5,2e-13,12.698970004336,null,1.4,"[0.50-2.30] % increase","Affymetrix, Illumina, and Perlegen [~2.6 million] (imputed)","N"]
["V1 (up-regulated)","11/18/2011",22001757,"Chambers JC","10/16/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22001757","Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.","Liver enzyme levels (gamma-glutamyl transferase)"," (up-regulated) to 52,350 European ancestry individuals,  (up-regulated) to 8,739 Indian Asian individuals","NR","1p36.13",1,16505320,"RSG1, EPHA2",null,1969,128272,null,22.74,19.28,"rs1497406-G","rs1497406",0,1497406,null,1,0.56,3e-19,18.5228787452803,null,3.8,"[2.70-4.80] % increase","Affymetrix, Illumina, and Perlegen [~2.6 million] (imputed)","N"]
["V1 (up-regulated)","11/16/2011",22003152,"Grallert H","10/14/2011","Eur Heart J","http://www.ncbi.nlm.nih.gov/pubmed/22003152","Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies.","Lipoprotein-associated phospholipase A2 activity and mass","13,664 European ancestry individuals","NR","11q23.3",11,116648917,"ZNF259","- ",null,null,8882,null,null,"rs964184-C","rs964184",0,964184,"nearGene-3",0,0.86,8e-11,10.096910013008,"(Activity concentrations)",0.03,"[0.022-0.042] unit decrease","Affymetrix & Illumina [2,661,766] (imputed)","N"]
["V1 (up-regulated)","10/22/2011",21980494,"Germain M","09/27/2011","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/21980494","Genetics of venous thrombosis: insights from a new genome wide association study.","Venous thromboembolism","1,542 European ancestry cases, 1,110 European ancestry controls","NR","1q24.2",1,169514006,"F5, SLC19A2, NME7","- ",null,null,2153,null,null,"rs1018827-A","rs1018827",0,1018827,"intron",0,0.12,2e-26,25.698970004336,null,2.52,"[NR] ","Illumina [481,002]","N"]
["V1 (up-regulated)","10/16/2011",21946350,"Soler Artigas M","09/25/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21946350","Genome-wide association and large-scale follow  (up-regulated) identifies 16 new loci influencing lung function.","Pulmonary function","48,201 European ancestry individuals","46,411 European ancestry individuals","16q21",16,58075282,"MMP15","- ",null,null,4324,null,null,"rs12447804-T","rs12447804",0,12447804,"intron",0,0.21,4e-08,7.39794000867203,"(FEV1/FVC)",0.04,"[0.024-0.052] unit decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","10/21/2011",21909115,"Ehret GB","09/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21909115","Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.","Diastolic blood pressure","69,395 European ancestry individuals"," (up-regulated) to 133,361 European ancestry individuals","20p12.2",20,10969030,"JAG1",null,170513,128718,null,99.29,357,"rs1327235-G","rs1327235",0,1327235,null,1,0.46,1e-15,15,null,0.3,"[NR] mmHg increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","10/21/2011",21909115,"Ehret GB","09/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21909115","Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.","Diastolic blood pressure","69,395 European ancestry individuals"," (up-regulated) to 133,361 European ancestry individuals","15q26.1",15,91437388,"FURIN, FES","- ",null,null,2242,null,null,"rs2521501-T","rs2521501",0,2521501,"intron",0,0.31,2e-15,14.698970004336,null,0.36,"[NR] mmHg increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","10/21/2011",21909115,"Ehret GB","09/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21909115","Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.","Hypertension","69,395 European ancestry individuals"," (up-regulated) to 133,361 European ancestry individuals","15q26.1",15,91437388,"FURIN, FES","- ",null,null,2242,null,null,"rs2521501-T","rs2521501",0,2521501,"intron",0,0.31,7e-07,6.15490195998574,null,0.06,"[NR] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","10/21/2011",21909115,"Ehret GB","09/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21909115","Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.","Systolic blood pressure","69,395 European ancestry individuals"," (up-regulated) to 133,361 European ancestry individuals","20p12.2",20,10969030,"JAG1",null,170513,128718,null,99.29,357,"rs1327235-G","rs1327235",0,1327235,null,1,0.46,2e-08,7.69897000433601,null,0.34,"[NR] mmHg increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","10/21/2011",21909115,"Ehret GB","09/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21909115","Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.","Systolic blood pressure","69,395 European ancestry individuals"," (up-regulated) to 133,361 European ancestry individuals","15q26.1",15,91437388,"FURIN, FES","- ",null,null,2242,null,null,"rs2521501-T","rs2521501",0,2521501,"intron",0,0.31,5e-19,18.3010299956639,null,0.65,"[NR] mmHg increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","10/11/2011",21909109,"Kim YJ","09/11/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21909109","Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.","HDL cholesterol","12,545 Korean ancestry individuals"," (up-regulated) to 30,395 East Asian ancestry individuals","19q13.32",19,45376284,"PVRL2, TOMM40, APOE","- ",null,null,5819,null,null,"rs519113-C","rs519113",0,519113,"intron",0,0.15,8e-11,10.096910013008,null,0.02,"[0.012-0.023] mg/dL decrease","Affymetrix [~2.2 million] (imputed)","N"]
["V1 (up-regulated)","10/11/2011",21909109,"Kim YJ","09/11/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21909109","Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.","Triglycerides","12,545 Korean ancestry individuals"," (up-regulated) to 30,395 East Asian ancestry individuals","11q23.3",11,116654435,"ZNF259, APOA1, APOC3, APOA4, APOA5, BUD13","- ",null,null,8882,null,null,"rs603446-T","rs603446",0,603446,"intron",0,0.23,2e-86,85.698970004336,null,0.09,"[0.079-0.096] mg/dL decrease","Affymetrix [~2.2 million] (imputed)","N"]
["V1 (up-regulated)","10/11/2011",21909110,"Wain LV","09/11/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21909110","Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.","Blood pressure","74,064 European ancestry individuals","48,607 European ancestry individuals","20p12.2",20,10969030,"JAG1",null,170513,128718,null,99.29,357,"rs1327235-G","rs1327235",0,1327235,null,1,0.58,4e-08,7.39794000867203,"(Mean Arterial Pressure)",0.26,"[0.17-0.35] mmHg increase","Affymetrix, Illumina, and Perlegen [NR] (imputed)","N"]
["V1 (up-regulated)","02/24/2012",21886157,"Suhre K","08/31/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21886157","Human metabolic individuality in biomedical and pharmaceutical research.","Metabolic traits","2,820 European ancestry individuals","NR","6q14.3",6,86117129,"NT5E",null,643858,100873911,null,121.75,19.24,"rs494562-G","rs494562",0,494562,null,1,0.106,7e-13,12.1549019599857,"(inosine + 1 other trait)",0.3,"[NR] unit increase","Affmyetrix & Illumina [534,665] ","N"]
["V1 (up-regulated)","02/24/2012",21886157,"Suhre K","08/31/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21886157","Human metabolic individuality in biomedical and pharmaceutical research.","Metabolic traits","2,820 European ancestry individuals","NR","10q24.31",10,102075479,"SCD","- ",null,null,9033,null,null,"rs603424-A","rs603424",0,603424,"intron",0,0.189,3e-57,56.5228787452803,"(SM-6 + 94 other traits)",0.12,"[NR] unit increase","Affmyetrix & Illumina [534,665] ","N"]
["V1 (up-regulated)","10/24/2012",21833088,"Sawcer S","08/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21833088","Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.","Multiple sclerosis","9,772 European ancestry cases, 16,849 European ancestry controls","4,218 European ancestry cases, 7,296 European ancestry controls","8q24.21",8,128815029,"MYC",null,100302185,100302161,null,6.76,157.85,"rs4410871-G","rs4410871",0,4410871,null,1,"NR",8e-09,8.09691001300805,null,1.11,"[1.09-1.12] ","Illumina [465,434]","N"]
["V1 (up-regulated)","09/06/2011",21846871,"Mehta NN","08/01/2011","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/21846871","A genome-wide association study in europeans and South asians identifies 5 new Loci for coronary artery disease.","Coronary heart disease","8,424 European ancestry cases, 6,996 South Asian cases, 15,062 controls","21,408 cases, 19,185 controls","1p32.2",1,56966350,"PPAP2B","- ",null,null,8613,null,null,"rs17114046-?","rs17114046",0,17114046,"intron",0,"NR",3e-07,6.52287874528033,null,"NR","NR","Illumina [~575,00]","N"]
["V1 (up-regulated)","08/03/2011",21729881,"Major JM","07/05/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21729881","Genome-wide association study identifies common variants associated with circulating vitamin E levels.","Vitamin E levels","2,402 European ancestry cases, 1612 European ancestry controls","1891 European ancestry cases, 1876 European ancestry controls","11q23.3",11,116648917,"BUD13, ZNF259, APOA5","- ",null,null,8882,null,null,"rs964184-G","rs964184",0,964184,"nearGene-3",0,0.15,8e-12,11.096910013008,null,0.04,"[0.02-0.06] unit increase","Illumina [NR] (imputed)","N"]
["V1 (up-regulated)","06/29/2011",21653640,"Eleftherohorinou H","06/13/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21653640","Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways.","Rheumatoid arthritis","2768 European ancestry cases, 4198 European ancestry controls","NR","6p21.33",6,31379931,"MICA","- ",null,null,100507436,null,null,"rs1063635-?","rs1063635",0,1063635,"missense",0,"NR",1e-17,17,null,1.35,"[1.27-1.45] ","Affymetrix & Illumina [NR]","N"]
["V1 (up-regulated)","06/29/2011",21665990,"Yu Y","06/10/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21665990","Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.","Age-related macular degeneration","2,594 European ancestry cases, 4,134 European ancestry controls","5,640 cases, 52,174 controls","6p21.1",6,43828582,"VEGFA",null,7422,221416,null,74.36,139.76,"rs4711751-T","rs4711751",0,4711751,null,1,0.5,9e-09,8.04575749056067,null,1.15,"[NR] ","Affymetrix [6,036,699] (imputed)","N"]
["V1 (up-regulated)","07/13/2011",21572416,"Kato N","05/15/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21572416","Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.","Blood pressure","17,089 East Asian ancestry individuals, 2,519 Malay ancestry individuals","30,765 East Asian ancestry individuals","12q24.13",12,112817783,"RPL6, PTPN11, ALDH2","- ",null,null,283450,null,null,"rs11066280-T","rs11066280",0,11066280,"intron",0,0.75,8e-31,30.096910013008,"(Systolic)",1.56,"[1.31-1.81] mm Hg increase","Affymetrix & Illumina [1.7 million] (imputed)","N"]
["V1 (up-regulated)","07/13/2011",21572416,"Kato N","05/15/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21572416","Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.","Blood pressure","17,089 East Asian ancestry individuals, 2,519 Malay ancestry individuals","30,765 East Asian ancestry individuals","12q24.13",12,112817783,"RPL6, PTPN11, ALDH2","- ",null,null,283450,null,null,"rs11066280-T","rs11066280",0,11066280,"intron",0,0.75,1e-35,35,"(Diastolic)",1.01,"[0.85-1.17] mm Hg increase","Affymetrix & Illumina [1.7 million] (imputed)","N"]
["V1 (up-regulated)","05/26/2011",21502949,"Stein JL","04/19/2011","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/21502949","Discovery and replication of dopamine-related gene effects on caudate volume in young and elderly populations (N=1198) using genome-wide search.","Caudate nucleus volume","734 European acnestry individuals","464 European acnestry individuals ","5q13.3",5,76781471,"WDR41,PDE8B","- ",null,null,55255,null,null,"rs163030-A","rs163030",0,163030,"intron",0,0.5,2e-07,6.69897000433601,"(Right caudate)",117.5,"[73.01-161.99] mm3 increase","Illumina [520,459]","N"]
["V1 (up-regulated)","05/11/2011",21499248,"Kumar V","04/17/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21499248","Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.","Hepatocellular carcinoma","721 Japanese ancestry cases, 2,890 Japanese ancestry controls","673 Japanese ancestry cases, 2,596 Japanese ancestry controls","6p21.33",6,31366595,"MICA","- ",null,null,100507436,null,null,"rs2596542-A","rs2596542",0,2596542,"nearGene-5",0,0.33,4e-13,12.397940008672,null,1.39,"[1.27-1.52] ","Illumina [432,703]","N"]
["V1 (up-regulated)","05/24/2011",21490949,"Sim X","04/07/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21490949","Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.","Type 2 diabetes","2,010 Chinese ancestry cases, 1,945 Chinese ancestry controls, 794 Malaysian ancestry cases, 1,240 Malyasian ancestry controls, 977 Asian Indian ancestry cases, 1,169 Asian Indian ancestry controls","NR","7q22.1",7,100490077,"ACHE","- ",null,null,43,null,null,"rs7636-A","rs7636",0,7636,"cds-synon",0,0.06,5e-06,5.30102999566398,"(Indian)",1.85,"[1.42-2.41] ","Illumina [~2,000,000] (imputed)","N"]
["V1 (up-regulated)","04/12/2011",21399633,"Gharavi AG","03/13/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21399633","Genome-wide association study identifies susceptibility loci for IgA nephropathy.","Nephropathy","1,194 Chinese ancestry cases, 902 Chinese ancestry controls","712 Chinese ancestry cases, 748 Chinese ancestry controls, 1,238 European ancestry cases, 1,172 European ancestry controls","22q12.2",22,30494371,"HORMAD2, MTMR3, LIF, OSM","- ",null,null,150280,null,null,"rs2412971-?","rs2412971",0,2412971,"intron",0,"0.49 (EA)",2e-09,8.69897000433601,null,1.25,"[NR] ","Illumina [498,322]","N"]
["V1 (up-regulated)","04/11/2011",21386085,"Kraja AT","03/08/2011","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/21386085","A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.","HDL Cholesterol - Triglycerides (HDLC-TG)","22,161 European ancestry individuals","NR","8q24.13",8,126484526,"TRIB1",null,10221,100130231,null,33.88,450.24,"rs2954026-G","rs2954026",0,2954026,null,1,"NR",8e-09,8.09691001300805,null,0.16,"[0.10-0.22] unit decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","04/11/2011",21386085,"Kraja AT","03/08/2011","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/21386085","A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.","HDL Cholesterol - Triglycerides (HDLC-TG)","22,161 European ancestry individuals","NR","11q23.3",11,116653296,"ZNF259","- ",null,null,8882,null,null,"rs2075290-C","rs2075290",0,2075290,"intron",0,"NR",2e-14,13.698970004336,null,0.39,"[0.29-0.49] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","04/11/2011",21386085,"Kraja AT","03/08/2011","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/21386085","A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.","Metabolic syndrome","22,161 European ancestry individuals","NR","11q23.3",11,116653296,"ZNF259","- ",null,null,8882,null,null,"rs2075290-C","rs2075290",0,2075290,"intron",0,"NR",2e-09,8.69897000433601,null,0.26,"[0.18-0.34] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","04/11/2011",21386085,"Kraja AT","03/08/2011","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/21386085","A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.","Metabolic syndrome (bivariate traits)","22,161 European ancestry individuals","NR","11q23.3",11,116652207,"ZNF259","- ",null,null,8882,null,null,"rs12286037-C","rs12286037",0,12286037,"intron",0,"NR",1e-08,8,"(TG-GLUC)",0.32,"[0.20-0.44] unit decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","04/11/2011",21386085,"Kraja AT","03/08/2011","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/21386085","A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.","Triglycerides-Blood Pressure (TG-BP)","22,161 European ancestry individuals","NR","8q24.13",8,126493746,"TRIB1",null,10221,100130231,null,43.1,441.02,"rs2954033-A","rs2954033",0,2954033,null,1,"NR",9e-09,8.04575749056067,null,0.17,"[0.11-0.23] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","04/11/2011",21386085,"Kraja AT","03/08/2011","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/21386085","A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.","Triglycerides-Blood Pressure (TG-BP)","22,161 European ancestry individuals","NR","11q23.3",11,116649135,"ZNF259","- ",null,null,8882,null,null,"rs11823543-A","rs11823543",0,11823543,"nearGene-3",0,"NR",3e-09,8.52287874528033,null,0.35,"[0.23-0.47] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","04/11/2011",21386085,"Kraja AT","03/08/2011","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/21386085","A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.","Waist Circumference - Triglycerides (WC-TG)","22,161 European ancestry individuals","NR","11q23.3",11,116653296,"ZNF259","- ",null,null,8882,null,null,"rs2075290-C","rs2075290",0,2075290,"intron",0,"NR",1e-16,16,null,0.41,"[0.31-0.51] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","04/11/2011",21378990,"Schunkert H","03/06/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21378990","Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.","Coronary heart disease","22,233 European ancestry cases, 64,762 European ancestry controls","28,834 cases, 27,674 controls, 2,115 individuals.","11q23.3",11,116648917,"ZNF259, APOA5, APOA4, APOC3, APOA1","- ",null,null,8882,null,null,"rs964184-G","rs964184",0,964184,"nearGene-3",0,0.13,1e-17,17,null,1.13,"[1.10-1.16] ","Affymetrix & Illumina {~2.3 million] (imputed)","N"]
["V1 (up-regulated)","04/11/2011",21378990,"Schunkert H","03/06/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21378990","Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.","Coronary heart disease","22,233 European ancestry cases, 64,762 European ancestry controls","28,834 cases, 27,674 controls, 2,115 individuals.","1p32.2",1,56962821,"PPAP2B","- ",null,null,8613,null,null,"rs17114036-A","rs17114036",0,17114036,"intron",0,0.91,4e-19,18.397940008672,null,1.17,"[1.13-1.22] ","Affymetrix & Illumina {~2.3 million] (imputed)","N"]
["V1 (up-regulated)","04/11/2011",21378988,"The Coronary Artery Disease (C4D) Genetics Consortium","03/06/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21378988","A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.","Coronary heart disease","8,424 European ancestry cases, 7,268 European ancestry controls, 6,996 South Asian cases, 7,794 South Asian controls","18,049 European ancestry cases, 16,357 European ancestry controls, 3,359 South Asian cases, 2,828 South Asian controls","1p32.2",1,56966350,"PPAP2B","- ",null,null,8613,null,null,"rs17114046-?","rs17114046",0,17114046,"intron",0,"NR",2e-07,6.69897000433601,null,"NR","NR","Illumina [574,919]","N"]
["V1 (up-regulated)","04/06/2011",21364930,"Bol SM","02/25/2011","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/21364930","Genome-wide association study identifies single nucleotide polymorphism in DYRK1A associated with replication of HIV-1 in monocyte-derived macrophages.","HIV-1 replication","191 European ancestry individuals","31 individuals","21q22.13",21,38740824,"DYRK1A","- ",null,null,1859,null,null,"rs12483205-?","rs12483205",0,12483205,"intron",0,"NR",5e-06,5.30102999566398,null,"NR","NR","Illumina [494,656]","N"]
["V1 (up-regulated)","04/06/2011",21383967,"Zhernakova A","02/24/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21383967","Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.","Celiac disease and Rheumatoid arthritis","4,533 European ancestry celiac disease cases, 5,539 European ancestry rheumatoid arthritis cases, 27,981 European ancestry controls","2,169 celiac disease cases, 2,845 rheumatoid arthritis cases, 7,199 controls","1q23.1",1,159005649,"IFI16","- ",null,null,3428,null,null,"rs1772408-?","rs1772408",0,1772408,"intron",0,"NR",8e-07,6.09691001300805,null,"NR","NR","Illumina [472,854]","N"]
["V1 (up-regulated)","04/07/2011",21347282,"Lettre G","02/10/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21347282","Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.","Coronary heart disease","8,090 African American individuals","8,849 African American or African-Caribbean individuals","1q32.3",1,211700658,"SLC30A1",null,343035,7779,null,34.4,47.72,"rs7526425-?","rs7526425",1,1614866,null,1,0.84,1e-06,5.99999999999999,"(hypertension)",1.16,"[1.09-1.24] ","Affymetrix [~2.74 million] (imputed)","N"]
["V1 (up-regulated)","03/28/2011",21348951,"Parsa A","02/01/2011","Clin Transl Sci","http://www.ncbi.nlm.nih.gov/pubmed/21348951","Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.","Cardiac hypertrophy","851 Old Order Amish individuals",null,"20p12.2",20,11174903,"C20orf94,BTBD3,SNAP25,MKK5,JAG1",null,170513,128718,null,305.17,151.13,"rs2207418-?","rs2207418",0,2207418,null,1,"NR",9e-06,5.04575749056067,"(dominant)","NR","NR","Affymetrix [361,034]","N"]
["V1 (up-regulated)","01/15/2011",21173776,"de Moor MH","12/21/2010","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/21173776","Meta-analysis of genome-wide association studies for personality.","Personality dimensions","17,375 European ancestry adults","3,294 European ancestry adults","5q14.3",5,86432617,"RASA1",null,100422887,5921,null,21.85,131.45,"rs2032794-C","rs2032794",0,2032794,null,1,"NR",2e-06,5.69897000433601,"(openness to experience)",0.48,"[0.30-0.66] unit increase","Affymetrix, Illumina & Perlegen [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","01/09/2011",21182207,"Salyakina D","12/01/2010","Autism Res","http://www.ncbi.nlm.nih.gov/pubmed/21182207","Variants in several genomic regions associated with asperger disorder.","Asperger disorder","843 family members","NR","15q22.1",15,59174539,"SLTM,RNF111","- ",null,null,79811,null,null,"rs7179456-?","rs7179456",0,7179456,"intron",0,0.39,7e-06,5.15490195998574,null,"NR","NR","Illumina [439,282]","N"]
["V1 (up-regulated)","01/08/2011",21107309,"McClay JL","11/24/2010","Neuropsychopharmacology","http://www.ncbi.nlm.nih.gov/pubmed/21107309","Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.","Working memory","738 schizophrenia cases","NR","1q42.3",1,236313127,"GPR137B","- ",null,null,7107,null,null,"rs7520258-?","rs7520258",0,7520258,"intron",0,0.07,5e-07,6.30102999566398,"(olanzapine)","NR","NR","Affymetrix [492,900]","N"]
["V1 (up-regulated)","01/08/2011",21107309,"McClay JL","11/24/2010","Neuropsychopharmacology","http://www.ncbi.nlm.nih.gov/pubmed/21107309","Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.","Working memory","738 schizophrenia cases","NR","2p23.3",2,24521766,"ITSN2","- ",null,null,50618,null,null,"rs6707600-?","rs6707600",0,6707600,"intron",0,0.02,3e-06,5.52287874528033,"(olanzapine)","NR","NR","Affymetrix [492,900]","N"]
["V1 (up-regulated)","01/13/2011",21051598,"Pereyra F","11/04/2010","Science","http://www.ncbi.nlm.nih.gov/pubmed/21051598","The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.","HIV-1 control","516 European cases, 1,196 European controls, 341 African American cases, 892 African American controls, 117 Hispanic controls, 560 Hispanic controls","NR","6p21.33",6,31391401,"MICA",null,100507436,267016,null,8.31,38.22,"rs4418214-C","rs4418214",0,4418214,null,1,0.075,1e-34,34,"(European)",4.4,"[NR] ","Illumina [1,384,048] (imputed)","N"]
["V1 (up-regulated)","12/16/2010",21060863,"Ikram MK","10/28/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21060863","Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.","Retinal vascular caliber","15,358 Caucasian individuals","6,673 individuals","12q24.12",12,111910219,"ATXN2,PTPN11,SH2B3","- ",null,null,6311,null,null,"rs10774625-A","rs10774625",0,10774625,"intron",0,0.48,2e-13,12.698970004336,null,1.5,"[1.11-1.89] um increase","Affymetrix & Illumina [2.2 million] (imputed)","N"]
["V1 (up-regulated)","12/08/2010",20972438,"Rothman N","10/24/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20972438","A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.","Bladder cancer","3,532 European descent cases, 5,120 European descent controls","8,382 cases, 48,275 controls","8q24.21",8,128718068,"MYC",null,5462,4609,null,288.61,30.25,"rs9642880-T","rs9642880",0,9642880,null,1,0.45,2e-18,17.698970004336,null,1.21,"[1.16-1.27] ","Illumina [591,637]","N"]
["V1 (up-regulated)","11/17/2010",20935629,"Heid IM","10/10/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20935629","Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.","Waist-hip ratio"," (up-regulated) to 77,167 European descent individuals"," (up-regulated) to 113,636 European descent individuals","6p21.1",6,43758873,"VEGFA",null,7422,221416,null,4.65,209.46,"rs6905288-A","rs6905288",0,6905288,null,1,0.56,2e-26,25.698970004336,"(women)",0.05,"[NR] unit increase","Affymetrix, Illumina & Perlegen [ (up-regulated) to 2,850,269](imputed)","N"]
["V1 (up-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","5q35.1",5,171015623,"FBXW11",null,8817,23291,null,130.99,272.93,"rs6892884-?","rs6892884",0,6892884,null,1,"NR",4e-08,7.39794000867203,"(Conditioned on rs12153391)","NR","NR","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V1 (up-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","6p21.33",6,31139452,"MICA","- ",null,null,5460,null,null,"rs879882-?","rs879882",0,879882,"nearGene-5",0,"NR",2e-07,6.69897000433601,"(Conditioned on rs2256183)","NR","NR","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V1 (up-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","5q35.1",5,171203438,"FBXW11","- ",null,null,644994,null,null,"rs12153391-A","rs12153391",0,12153391,"intron",0,0.25,4e-12,11.397940008672,null,0.03,"[NR] unit decrease","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V1 (up-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","1p36.11",1,25044111,"CLIC4",null,10250,25932,null,44.34,27.65,"rs4601530-T","rs4601530",0,4601530,null,1,0.26,2e-12,11.698970004336,null,0.03,"[NR] unit decrease","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V1 (up-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","9q31.3",9,113807082,"LPAR1",null,1902,100379298,null,6.72,52.53,"rs1468758-T","rs1468758",0,1468758,null,1,0.25,1e-09,8.99999999999999,null,0.03,"[NR] unit decrease","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V1 (up-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","9q34.11",9,133464084,"FUBP3","- ",null,null,8939,null,null,"rs7466269-A","rs7466269",0,7466269,"intron",0,0.64,3e-17,16.5228787452803,null,0.03,"[NR] unit increase","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V1 (up-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","6p21.33",6,31380529,"MICA","- ",null,null,100507436,null,null,"rs2256183-A","rs2256183",0,2256183,"intron",0,0.45,8e-29,28.096910013008,null,0.04,"[NR] unit increase","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V1 (up-regulated)","10/14/2010",20885792,"Naj AC","09/23/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20885792","Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.","Alzheimer's disease (late onset)","931 cases, 1,104 controls","1,338 cases, 2,003 controls","19q13.32",19,45382034,"PVRL2","- ",null,null,5819,null,null,"rs6859-A","rs6859",0,6859,"intron",0,0.46,1e-07,7,null,1.41,"[1.24-1.60] ","Illumina [483,399]","N"]
["V1 (up-regulated)","10/17/2010",20864672,"Waterworth DM","09/23/2010","Arterioscler Thromb Vasc Biol","http://www.ncbi.nlm.nih.gov/pubmed/20864672","Genetic variants influencing circulating lipid levels and risk of coronary artery disease.","HDL cholesterol"," (up-regulated) to 17,243 white European descent individuals"," (up-regulated) to 37,774 white European descent individuals,  (up-regulated) to 9,665 Indian Asian individuals","11q23.3",11,116648917,"ZNF259, APOA5,APOA4,APOC3,APOA1","- ",null,null,8882,null,null,"rs964184-G","rs964184",0,964184,"nearGene-3",0,0.12,2e-11,10.698970004336,null,0.03,"[0.02-0.04] unit decrease","Affymetrix, Illumina & Perlegen [2,155,369] (imputed)","N"]
["V1 (up-regulated)","10/17/2010",20864672,"Waterworth DM","09/23/2010","Arterioscler Thromb Vasc Biol","http://www.ncbi.nlm.nih.gov/pubmed/20864672","Genetic variants influencing circulating lipid levels and risk of coronary artery disease.","LDL cholesterol"," (up-regulated) to 17,243 white European descent individuals"," (up-regulated) to 37,774 white European descent individuals,  (up-regulated) to 9,665 Indian Asian individuals","8q24.13",8,126482077,"TRIB1",null,10221,100130231,null,31.43,452.69,"rs2954021-G","rs2954021",0,2954021,null,1,0.5,1e-07,7,null,0.02,"[0.01-0.03] unit decrease","Affymetrix, Illumina & Perlegen [2,155,369] (imputed)","N"]
["V1 (up-regulated)","10/17/2010",20864672,"Waterworth DM","09/23/2010","Arterioscler Thromb Vasc Biol","http://www.ncbi.nlm.nih.gov/pubmed/20864672","Genetic variants influencing circulating lipid levels and risk of coronary artery disease.","LDL cholesterol"," (up-regulated) to 17,243 white European descent individuals"," (up-regulated) to 37,774 white European descent individuals,  (up-regulated) to 9,665 Indian Asian individuals","11q23.3",11,116607437,"BUD13, ZNF259, APOA5,APOA4,APOC3,APOA1",null,100128347,84811,null,785.92,11.45,"rs1558861-T","rs1558861",0,1558861,null,1,0.94,2e-06,5.69897000433601,null,0.03,"[0.02-0.04] unit decrease","Affymetrix, Illumina & Perlegen [2,155,369] (imputed)","N"]
["V1 (up-regulated)","10/17/2010",20864672,"Waterworth DM","09/23/2010","Arterioscler Thromb Vasc Biol","http://www.ncbi.nlm.nih.gov/pubmed/20864672","Genetic variants influencing circulating lipid levels and risk of coronary artery disease.","Triglycerides"," (up-regulated) to 17,243 white European descent individuals"," (up-regulated) to 37,774 white European descent individuals,  (up-regulated) to 9,665 Indian Asian individuals","11q23.3",11,116584987,"BUD13,ZNF259,APOA5,APOA4,APOC3,APOA1",null,100128347,84811,null,763.47,33.9,"rs4938303-T","rs4938303",0,4938303,null,1,0.75,4e-21,20.397940008672,null,0.07,"[0.06-0.08] unit decrease","Affymetrix, Illumina & Perlegen [2,155,369] (imputed)","N"]
["V1 (up-regulated)","10/17/2010",20864672,"Waterworth DM","09/23/2010","Arterioscler Thromb Vasc Biol","http://www.ncbi.nlm.nih.gov/pubmed/20864672","Genetic variants influencing circulating lipid levels and risk of coronary artery disease.","Triglycerides"," (up-regulated) to 17,243 white European descent individuals"," (up-regulated) to 37,774 white European descent individuals,  (up-regulated) to 9,665 Indian Asian individuals","8q24.13",8,126490972,"TRIB1",null,10221,100130231,null,40.33,443.8,"rs2954029-T","rs2954029",0,2954029,null,1,0.46,2e-11,10.698970004336,null,0.04,"[0.03-0.05] unit decrease","Affymetrix, Illumina & Perlegen [2,155,369] (imputed)","N"]
["V1 (up-regulated)","10/12/2010",20852632,"Goode EL","09/19/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20852632","A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.","Ovarian cancer","1,768 European ancestry cases, 2,354 European ancestry controls","8,709 European ancestry cases, 51,764 European ancestry controls","3q25.31",3,156397749,"TIPARP","- ",null,null,25976,null,null,"rs2665390T-C","rs2665390",0,2665390,"intron",0,"NR",3e-07,6.52287874528033,null,1.19,"[1.11-1.27] ","Illumina [2,056,878] (imputed)","N"]
["V1 (up-regulated)","10/12/2010",20852632,"Goode EL","09/19/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20852632","A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.","Ovarian cancer","1,768 European ancestry cases, 2,354 European ancestry controls","8,709 European ancestry cases, 51,764 European ancestry controls","8q24.21",8,129543949,"MYC,THEM75",null,100302281,100500839,null,381.52,952.35,"rs10088218-G","rs10088218",0,10088218,null,1,"NR",3e-09,8.52287874528033,null,1.19,"[1.12-1.25] ","Illumina [2,056,878] (imputed)","N"]
["V1 (up-regulated)","09/24/2010",20708005,"Chalasani N","08/10/2010","Gastroenterology","http://www.ncbi.nlm.nih.gov/pubmed/20708005","Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.","Non-alcoholic fatty liver disease histology (lobular)","236 non-Hispanic Caucasian women","NR","10q22.1",10,71588504,"COL13A1","- ",null,null,1305,null,null,"rs1227756-G","rs1227756",0,1227756,"intron",0,0.46,2e-07,6.69897000433601,null,0.57,"[NR] unit increase","Illumina [324,623]","N"]
["V1 (up-regulated)","09/24/2010",20708005,"Chalasani N","08/10/2010","Gastroenterology","http://www.ncbi.nlm.nih.gov/pubmed/20708005","Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.","Non-alcoholic fatty liver disease histology (lobular)","236 non-Hispanic Caucasian women","NR","10q22.1",10,71583198,"COL13A1","- ",null,null,1305,null,null,"rs7077164-A","rs7077164",0,7077164,"intron",0,0.3,7e-06,5.15490195998574,null,0.67,"[NR] unit increase","Illumina [324,623]","N"]
["V1 (up-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","Cholesterol, total"," (up-regulated) to 100,184 European descent individuals",null,"8q24.13",8,126490972,"TRIB1",null,10221,100130231,null,40.33,443.8,"rs2954029-A ","rs2954029",0,2954029,null,1,0.46,5e-36,35.3010299956639,null,2.3,"[1.93-2.67] mg/dL decrease","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V1 (up-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","HDL cholesterol","99,900 European descent individuals",null,"8q24.13",8,126490972,"TRIB1",null,10221,100130231,null,40.33,443.8,"rs2954029-T ","rs2954029",0,2954029,null,1,0.44,6e-19,18.2218487496163,null,0.61,"[0.47-0.75] mg/dL increase","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V1 (up-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","LDL cholesterol"," (up-regulated) to 95,454 European descent individuals",null,"8q24.13",8,126490972,"TRIB1",null,10221,100130231,null,40.33,443.8,"rs2954029-A ","rs2954029",0,2954029,null,1,0.46,3e-29,28.5228787452803,null,1.84,"[1.51-2.17] mg/dL decrease","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V1 (up-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","Triglycerides"," (up-regulated) to 96,598 European descent individuals",null,"8q24.13",8,126490972,"TRIB1",null,10221,100130231,null,40.33,443.8,"rs2954029-T","rs2954029",0,2954029,null,1,0.47,3e-55,54.5228787452803,null,5.64,"[4.88-6.4] mg/dL decrease","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V1 (up-regulated)","09/13/2010",20694148,"Zabaneh D","08/04/2010","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/20694148","A genome-wide association study of the metabolic syndrome in Indian Asian men.","Metabolic syndrome","2,554 Indian Asian men","2,240 Indian Asian men","21q22.13",21,38932778,"DYRK1A",null,1859,3763,null,45.1,64,"rs2835810-?","rs2835810",0,2835810,null,1,0.37,6e-06,5.22184874961635,"(WHR)","NR","NR","Illumina [308,011]","N"]
["V1 (up-regulated)","09/13/2010",20694148,"Zabaneh D","08/04/2010","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/20694148","A genome-wide association study of the metabolic syndrome in Indian Asian men.","Metabolic syndrome","2,554 Indian Asian men","2,240 Indian Asian men","18q21.32",18,57751014,"PMAIP1",null,728115,400652,null,66.21,65.76,"rs12957347-?","rs12957347",0,12957347,null,1,0.36,7e-06,5.15490195998574,"(Metabolic syndrome)","NR","NR","Illumina [308,011]","N"]
["V1 (up-regulated)","07/04/2010",20548944,"Hsu YH","06/10/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20548944","An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.","Osteoporosis","2,038 European ancestry women, 1,531 European ancestry  men","5,595 European ancestry women, 2,126 European ancestry men","18q11.2",18,21938658,"OSBPL1A","- ",null,null,114876,null,null,"rs7227401-T","rs7227401",0,7227401,"intron",0,0.39,4e-07,6.39794000867203,"(NW, men)",0.17,"[NR] cm increase","Affymetrix [433,510]","N"]
["V1 (up-regulated)","05/26/2010",20442857,"Suchindran S","04/29/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20442857","Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.","Lipoprotein-associated phospholipase A2 activity and mass","6,668 Caucasian individuals","NR","11q23.3",11,116652207,"ZNF259","- ",null,null,8882,null,null,"rs12286037-T","rs12286037",0,12286037,"intron",0,0.07,4e-08,7.39794000867203,"(activity)",6.4,"[NR] nmol/ml/min increase","Affymetrix [360,811]","N"]
["V1 (up-regulated)","05/23/2010",20400778,"Morrison AC","04/17/2010","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/20400778","Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium.","Mortality among heart failure patients","2,526 European ancestry individuals, 466 African ancestry individuals","NR","7q31.1",7,112086333,"IFRD1","- ",null,null,3475,null,null,"rs17159640-T","rs17159640",0,17159640,"intron",0,0.048,9e-06,5.04575749056067,"(EA)",1.59,"[0.94-2.68] ","Affymetrix [~2.4 million] (imputed)","N"]
["V1 (up-regulated)","05/05/2010",20383146,"Kottgen A","04/11/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20383146","New loci associated with kidney function and chronic kidney disease.","Chronic kidney disease"," (up-regulated) to 67,093 European ancestry individuals"," (up-regulated) to 22,982 European ancestry individuals","6p21.1",6,43806609,"VEGFA",null,7422,221416,null,52.39,161.73,"rs881858-G","rs881858",0,881858,null,1,0.28,9e-14,13.0457574905606,"(eGFRcrea)",1.08,"[0.007-0.015] ml/min/1.73 m2 increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","04/14/2010",20348956,"Kiemeney LA","03/28/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20348956","A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.","Urinary bladder cancer","611 Icelandic cases, 37,478 Icelandic controls, 1,278 Dutch cases, 1,832 Dutch controls","771 English cases, 574 English controls, 515 Italian cases, 584 English controls, 201 Belgian cases, 385 Belgian controls, 214 Eastern European cases, 533 Eastern European controls, 352 Swedish cases, 1,350 Swedish controls, 246 Spanish cases, 890 Spanish controls, 217 German cases, 202 German controls, 334 Dutch cases, 1,721 Dutch controls","8q24.21",8,128718068,"MYC",null,5462,4609,null,288.61,30.25,"rs9642880-T","rs9642880",0,9642880,null,1,0.44,7e-12,11.1549019599857,null,1.21,"[1.15-1.28] ","Illumina [304,703]","N"]
["V1 (up-regulated)","04/14/2010",20339536,"Barber MJ","03/22/2010","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/20339536","Genome-wide association of lipid-lowering response to statins in combined study populations.","Response to statin therapy","3,928 Caucasian individuals","NR","8q24.13",8,126507389,"TRIB1, NSMCE2, KIAA0196",null,10221,100130231,null,56.74,427.38,"rs2954038-C","rs2954038",0,2954038,null,1,0.32,7e-06,5.15490195998574,"(Triglyceride, sum)","NR","NR","Illumina [~2.5 million](imputed)","N"]
["V1 (up-regulated)","04/14/2010",20339536,"Barber MJ","03/22/2010","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/20339536","Genome-wide association of lipid-lowering response to statins in combined study populations.","Response to statin therapy","3,928 Caucasian individuals","NR","14q32.13",14,95720678,"CLMN, FLJ45244, DICER1","- ",null,null,79789,null,null,"rs8014194-A","rs8014194",0,8014194,"intron",0,0.24,2e-08,7.69897000433601,"(chol, diff)","NR","NR","Illumina [~2.5 million](imputed)","N"]
["V1 (up-regulated)","02/10/2010",20096396,"Kung AW","01/20/2010","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/20096396?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=4","Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow- (up-regulated) replication studies.","Bone mineral density","785 Hong Kong Southern Chinese (HSKC) extreme BMD females","720 HKSC extreme BMD individuals, 17,378 individuals of European or Asian descent","20p12.2",20,10639543,"JAG1","- ",null,null,182,null,null,"rs2273061-A","rs2273061",0,2273061,"intron",0,0.31,5e-08,7.30102999566398,"(lumbar spine)",0.07,"[NR] s.d. increase","Illumina [488,853]","N"]
["V1 (up-regulated)","01/21/2010",20062064,"Crowther-Swanepoel D","01/10/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20062064?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk.","Chronic lymphocytic leukemia","505 European cases, 1,438 European controls","1,998 European cases, 4,351 European controls","18q21.1",18,47843534,"CXXC1, MBD1",null,30827,220134,null,28.84,57.86,"rs1036935-T","rs1036935",0,1036935,null,1,"NR",2e-06,5.69897000433601,null,1.22,"[1.12-1.32] ","Illumina [299,983]","N"]
["V1 (up-regulated)","12/10/2009",19915574,"Imielinski M","11/15/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19915574?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Common variants at five new loci associated with early-onset inflammatory bowel disease.","Inflammatory bowel disease (early onset)","2,413 European ancestry cases, 6,158 European ancestry controls","1,013 European ancestry cases, 5,805 European ancestry controls","22q12.2",22,30529631,"HORMAD2, MTMR3, LIF","- ",null,null,150280,null,null,"rs2412973-?","rs2412973",0,2412973,"intron",0,0.46,2e-09,8.69897000433601,null,1.15,"[1.01-1.31] ","Illumina [~500,000]","N"]
["V1 (up-regulated)","11/03/2009",19862010,"Ganesh SK","10/11/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19862010?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.","Mean corpuscular hemoglobin","24,167 European ancestry individuals","9,456 European ancestry individuals","3q29",3,195809139,"TFRC","- ",null,null,7037,null,null,"rs11915082-A","rs11915082",0,11915082,"nearGene-5",0,"NR",8e-13,12.096910013008,null,0,"[0.003-0.005] pg increase","Affymetrix & Illumina [~2.5 million](imputed)","N"]
["V1 (up-regulated)","11/03/2009",19862010,"Ganesh SK","10/11/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19862010?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.","Mean corpuscular volume","24,167 European ancestry individuals","9,456 European ancestry individuals","3q29",3,195800547,"TFRC","- ",null,null,7037,null,null,"rs9859260-C","rs9859260",0,9859260,"intron",0,"NR",8e-14,13.096910013008,null,0,"[0.002-0.004] fl increase","Affymetrix & Illumina [~2.5 million](imputed)","N"]
["V1 (up-regulated)","10/30/2009",19820697,"Soranzo N","10/11/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19820697?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.","Hematological parameters","4,627 European individuals","9,316 European individuals","12q24.13",12,112871372,"PTPN11","- ",null,null,5781,null,null,"rs11066301-G","rs11066301",0,11066301,"intron",0,"NR",8e-12,11.096910013008,"(PLT)",4.65,"[3.32-5.98] 10^9/l increase","Affymetrix and Illumina [~2.11 million] (imputed)","N"]
["V1 (up-regulated)","11/08/2012",19734545,"Need AC","09/04/2009","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19734545?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.","Cognitive performance"," (up-regulated) to 1,295 individuals","NR","2q31.1",2,171822466,"GORASP2","- ",null,null,26003,null,null,"rs4668356-?","rs4668356",0,4668356,"cds-synon",0,0.06041,1e-06,5.99999999999999,"(PAL8)","NR","NR","Illumina [475,971]","N"]
["V1 (up-regulated)","11/08/2012",19734545,"Need AC","09/04/2009","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19734545?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.","Cognitive performance"," (up-regulated) to 1,295 individuals","NR","1p32.1",1,59325626,"JUN","- ",null,null,100131060,null,null,"rs4601609-?","rs4601609",0,4601609,"intron",0,0.04517,5e-06,5.30102999566398,"(PRM)","NR","NR","Illumina [475,971]","N"]
["V1 (up-regulated)","09/09/2009",19714205,"Hancock DB","08/28/2009","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/19714205?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children.","Asthma (childhood onset)","492 Mexican trios","177 Mexican trios","9q21.31",9,82039362,"TLE4, CHCHD9",null,645345,7091,null,32.41,147.52,"rs2378383-?","rs2378383",0,2378383,null,1,0.78,7e-07,6.15490195998574,null,1.64,"[1.32-2.04] ","Illumina [520,767]","N"]
["V1 (up-regulated)","08/07/2009",19584346,"Vasan RS","07/08/2009","JAMA","http://www.ncbi.nlm.nih.gov/pubmed/19584346?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.","Cardiac structure and function","12,612 European ancestry individuals","4,094 European ancestry individuals","5q22.1",5,110008214,"SLC25A46","- ",null,null,642987,null,null,"rs17132261-T","rs17132261",0,17132261,"intron",0,0.02,9e-07,6.04575749056067,"(LV wall thickness)",0.06,"[0.04-0.08] cm increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (up-regulated)","05/21/2009",19421330,"Yang HC","05/07/2009","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/19421330","Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan.","Hypertension (young onset)","175 Han Chinese cases, 175 Han Chinese controls","833 Han Chinese cases, 833 Han Chinese controls","2p22.3[rs9308945]; 2p22.3[rs6711736]",null,null,"LOC344371, MYADML, FAM98A, RASGRP3","- ",{"$nulls":5},"4-SNP-haplotype","rs9308945,rs6711736,rs6729869,rs10495809",{"$nulls":4},"NR",3e-10,null,null,"NR","NR","Affymetrix [91,713]","N"]
["V1 (up-regulated)","03/31/2009",19305408,"Newton-Cheh C","03/22/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19305408?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Common variants at ten loci influence QT interval duration in the QTGEN Study.","QT interval","13,685 individuals","15,854 individuals","16q21",16,58567238,"CNOT1,GINS3, NDRG4, SLC38A7, GOT2","- ",null,null,23019,null,null,"rs37062-G","rs37062",0,37062,"intron",0,0.24,3e-25,24.5228787452803,null,1.75,"[1.41-2.09] msec decrease","Affymetrix and Illumina [ (up-regulated) to 2,543,686] (imputed)","N"]
["V1 (up-regulated)","10/15/2009",19197348,"Lowe JK","02/06/2009","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/19197348","Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.","Quantitative traits"," (up-regulated) to 2,906 Micronesian individuals","NR","12p13.33",12,2882544,"ENSG00000118975, FKBP4","- ",null,null,283440,null,null,"rs10848704-C","rs10848704",0,10848704,"nearGene-5",0,0.35,2e-06,5.69897000433601,"(TSH)",0.29,"[NR] mIU/L decrease","Affymetrix [408,775]","N"]
["V1 (up-regulated)","01/14/2009",19084217,"Benyamin B","12/17/2008","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/19084217?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.","Iron status biomarkers","459 twin pairs","NR","6q25.3",6,160137687,"WTAP",null,6648,9589,null,23.33,10.34,"rs4516970-?","rs4516970",0,4516970,null,1,"NR",1e-06,5.99999999999999,"(serum ferritin)","NR","NR","Illumina [315,887]","N"]
["V1 (up-regulated)","01/12/2009",19060911,"Aulchenko YS","12/07/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19060911?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.","Cholesterol, total","22,562 individuals","NR","8q24.13",8,126504726,"TRIB1",null,10221,100130231,null,54.08,430.04,"rs6987702-G","rs6987702",0,6987702,null,1,0.29,3e-09,8.52287874528033,null,0.07,"[NR] s.d. increase","Illumina and Affymetrix [ (up-regulated) to ~600,000]","N"]
["V1 (up-regulated)","01/12/2009",19060911,"Aulchenko YS","12/07/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19060911?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.","LDL cholesterol","17,797 individuals","NR","8q24.13",8,126504726,"TRIB1",null,10221,100130231,null,54.08,430.04,"rs6987702-G","rs6987702",0,6987702,null,1,0.29,3e-06,5.52287874528033,null,0.07,"[NR] s.d. increase","Illumina and Affymetrix [ (up-regulated) to 600,000]","N"]
["V1 (up-regulated)","01/12/2009",19060906,"Kathiresan S","12/07/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19060906?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Common variants at 30 loci contribute to polygenic dyslipidemia.","Triglycerides","19,840 individuals"," (up-regulated) to 20,623 individuals","8q24.13",8,126490972,"TRIB1",null,10221,100130231,null,40.33,443.8,"rs2954029-T","rs2954029",0,2954029,null,1,0.44,3e-19,18.5228787452803,null,0.11,"[0.07-0.15] s.d. decrease","Affymetrix and Illumina [~2,600,000] (imputed)","N"]
["V1 (up-regulated)","01/16/2009",19010793,"Baranzini SE","11/14/2008","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19010793?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.","Multiple sclerosis (severity)","794 cases, 883 controls","NR","7q31.2",7,116346603,"MET","- ",null,null,4233,null,null,"rs10243024-?","rs10243024",0,10243024,"intron",0,0.23,6e-06,5.22184874961635,null,"NR","NR","Illumina[551,642]","N"]
["V1 (up-regulated)","12/09/2008",18951430,"Anney RJ","10/24/2008","Am J Med Genet B Neuropsychiatr Genet","http://www.ncbi.nlm.nih.gov/pubmed/18951430?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.","Attention deficit hyperactivity disorder and conduct disorder","938 affected trios","NR","12q21.2",12,80062230,"PAWR","- ",null,null,5074,null,null,"rs7297018-A","rs7297018",0,7297018,"intron",0,0.19,4e-06,5.39794000867203,null,"NR","NR","Perlegen[378,332]","N"]
["V1 (up-regulated)","11/25/2008",18823527,"Abraham R","09/29/2008","BMC Med Genomics","http://www.ncbi.nlm.nih.gov/pubmed/18823527?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","A genome-wide association study for late-onset Alzheimer's disease using DNA pooling.","Alzheimer's disease","1,082 cases,1,239 controls","1,400 additional controls","19q13.32",19,45382034,"PVRL2, TOMM40, APOE","- ",null,null,5819,null,null,"rs6859-A","rs6859",0,6859,"intron",0,"NR",6e-14,13.2218487496163,null,"NR","NR","Illumina[561,494](pooled)","N"]
["V1 (up-regulated)","11/25/2008",18794855,"Kiemeney LA","09/14/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18794855?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Sequence variant on 8q24 confers susceptibility to urinary bladder cancer.","Urinary bladder cancer","1,803 cases,34,336 controls","2,165 cases,3,800 controls","8q24.21",8,128718068,"MYC, BC042052",null,5462,4609,null,288.61,30.25,"rs9642880-T","rs9642880",0,9642880,null,1,0.45,9e-12,11.0457574905606,null,1.22,"[1.15-1.29] ","Illumina[302,140]","N"]
["V1 (up-regulated)","11/25/2008",18758461,"Di Bernardo MC","08/31/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18758461?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.","Chronic lymphocytic leukemia","505 cases, 1,438 controls","1,024 cases,1,677 controls","2q37.1",2,231091223,"SP140, SP110","- ",null,null,"3431;11262",null,null,"rs13397985-G","rs13397985",0,13397985,"nearGene-5;intron",0,0.19,6e-10,9.22184874961635,null,1.41,"[1.26-1.57] ","Illumina[345,665]","N"]
["V1 (up-regulated)","11/25/2008",18615156,"Liu C","07/10/2008","Mol Med","http://www.ncbi.nlm.nih.gov/pubmed/18615156?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.","Response to TNF antagonist treatment","89 cases","NR","6q26",6,164186677,"QKI",null,9444,168090,null,187.05,1506.48,"rs10945919-G","rs10945919",0,10945919,null,1,0.32,3e-07,6.52287874528033,null,"NR","NR","Illumina[283,348]","N"]
["V1 (up-regulated)","11/25/2008",18464913,"Melzer D","05/09/2008","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/18464913?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association study identifies protein quantitative trait loci (pQTLs).","Protein quantitative trait loci","1,200 individuals","NR","18q11.2",18,21749615,"OSBPL1A","- ",null,null,114876,null,null,"rs9635963-?","rs9635963",0,9635963,"intron",0,0.18,2e-07,6.69897000433601,"(SHBG)","NR","NR","Illumina[496,032]","N"]
["V1 (up-regulated)","11/25/2008",18471798,"Valdes AM","05/08/2008","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/18471798?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis.","Knee osteoarthritis","357 cases,285 controls","1,177 cases,2,372 controls","1q31.1",1,186725003,"PTGS2, PLA2G4A",null,5743,5321,null,75.44,73.03,"rs4140564-?","rs4140564",0,4140564,null,1,0.05,3e-06,5.52287874528033,null,1.59,"[1.31-1.94] ","Illumina[413,461]","N"]
["V1 (up-regulated)","11/25/2008",18391951,"Gudbjartsson DF","04/06/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18391951?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Many sequence variants affecting diversity of adult human height.","Height","30,968 individuals","8,541 individuals","8q12.1",8,57095808,"PLAG1, MOS, CHCHD7,RDHE2, RPS20,LYN, TGS1, PENK","- ",null,null,5324,null,null,"rs10958476-C","rs10958476",0,10958476,"intron",0,0.23,7e-08,7.15490195998574,null,5.4,"[3.44-7.36] % s.d. taller","Illumina and Affymetrix[ (up-regulated) to 304,226]","N"]
["V1 (up-regulated)","11/25/2008",18391950,"Lettre G","04/06/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18391950?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Identification of ten loci associated with height highlights new biological pathways in human growth.","Height","15,821 individuals","13,671 individuals","9q34.11",9,133464084,"FUBP3","- ",null,null,8939,null,null,"rs7466269-G","rs7466269",0,7466269,"intron",0,0.33,8e-07,6.09691001300805,null,0.27,"[0.38-0.69] cm shorter","Affymetrix and Illumina[2,260,683](imputed)","N"]
["V1 (up-regulated)","11/25/2008",18372903,"Zeggini E","03/30/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18372903?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.","Type 2 diabetes","4,549 cases,5,579 controls","24,194 cases,55,598 controls","6p21.1",6,43811762,"VEGFA",null,7422,221416,null,57.54,156.58,"rs9472138-T","rs9472138",0,9472138,null,1,0.28,4e-06,5.39794000867203,null,1.06,"[1.04-1.09] ","Affymetrix and Illumina[2,202,892](imputed)","N"]
["V1 (up-regulated)","11/25/2008",18204098,"Hom G","01/20/2008","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/18204098?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Association of systemic l (up-regulated)us erythematosus with C8orf13-BLK and ITGAM-ITGAX.","Systemic l (up-regulated)us erythematosus","1,311 cases,3,340 controls","793 cases,857 controls","18q22.3",18,68842243,"SOCS6",null,342808,147381,null,743.85,1361.67,"rs17083844-A","rs17083844",0,17083844,null,1,0.03,6e-06,5.22184874961635,null,"NR","NR","Illumina[502,033]","N"]
["V1 (up-regulated)","11/25/2008",18193044,"Kathiresan S","01/13/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18193044?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.","Triglycerides","2,758 individuals","18,544 individuals","11q23.3",11,116619073,"APOA1, APOC3, APOA4, APOA5, ZNF259, BUD13","- ",null,null,84811,null,null,"rs28927680-G","rs28927680",0,28927680,"UTR-3",0,0.07,2e-17,16.698970004336,null,0.26,"[0.20-0.32] % SD higher","Affymetrix[389,878]","N"]
["V1 (up-regulated)","11/25/2008",18193044,"Kathiresan S","01/13/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18193044?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.","Triglycerides","2,758 individuals","18,544 individuals","8q24.13",8,126486409,"TRIB1",null,10221,100130231,null,35.76,448.36,"rs17321515-G","rs17321515",0,17321515,null,1,0.49,4e-17,16.397940008672,null,0.08,"[0.06-0.10] % SD lower","Affymetrix[389,878]","N"]
["V1 (up-regulated)","11/25/2008",18193043,"Willer CJ","01/13/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18193043?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Newly identified loci that influence lipid concentrations and risk of coronary artery disease.","Triglycerides","8,684 individuals","5,312-9,707 individuals","8q24.13",8,126486409,"TRIB1",null,10221,100130231,null,35.76,448.36,"rs17321515-A","rs17321515",0,17321515,null,1,0.56,7e-13,12.1549019599857,null,6.42,"[NR] mg/dl higher","Illumina and Affymetrix[~2,261,000]] (imputed)","N"]
["V1 (up-regulated)","11/25/2008",17903297,"Seshadri S","09/19/2007","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/17903297?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.","Cognitive test performance","705 individuals(Framingham)","NR","1q42.2",1,234583618,"TARBP1","- ",null,null,6894,null,null,"rs10489896-?","rs10489896",0,10489896,"intron",0,"NR",6e-06,5.22184874961635,"(F2)","NR","NR","Affymetrix[70,897]","N"]
["V1 (up-regulated)","11/25/2008",17554300,"WTCCC","06/07/2007","Nature","http://www.ncbi.nlm.nih.gov/pubmed/17554300?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.","Type 1 diabetes","1,963 cases,2,938 controls","(see Todd 2007)","12q24.13",12,112486818,"SH2B3,LNK,TRAFD1,PTPN11","- ",null,null,80018,null,null,"rs17696736-G","rs17696736",0,17696736,"intron",0,0.42,2e-14,13.698970004336,null,1.34,"[1.16-1.53] ","Affymetrix[469,557]","N"]
["V1 (down-regulated)","06/26/2013",23535033,"Sherva R","03/24/2013","Alzheimers Dement","http://www.ncbi.nlm.nih.gov/pubmed/23535033","Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.","Alzheimer's disease (cognitive decline)","303 European ancestry cases",null,"4q21.3",4,87931404,"AFF1","- ",null,null,4299,null,null,"rs340635-?","rs340635",0,340635,"intron",0,0.03,2e-07,6.69897000433601,null,0.23,"unit decrease","Illumina [NR] (Imputed)","N"]
["V1 (down-regulated)","06/26/2013",23535033,"Sherva R","03/24/2013","Alzheimers Dement","http://www.ncbi.nlm.nih.gov/pubmed/23535033","Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.","Alzheimer's disease (cognitive decline)","303 European ancestry cases",null,"5q11.2",5,55510656,"ANKRD55","- ",null,null,79722,null,null,"rs4700060-?","rs4700060",0,4700060,"intron",0,0.1,1e-08,8,null,0.21,"unit decrease","Illumina [NR] (Imputed)","N"]
["V1 (down-regulated)","06/06/2013",23453885,"Smoller JW","02/27/2013","Lancet","http://www.ncbi.nlm.nih.gov/pubmed/23453885","Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.","Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined)","6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls","NR","1p36.23",1,8422676,"SLC45A1, RERE, ENO1","- ",null,null,473,null,null,"rs2252865-T","rs2252865",0,2252865,"intron",0,"NR",5e-07,6.30102999566398,"(5 degree of freedom test)",1.03,"[1.00-1.06] ","NR [1,252,901] (imputed)","N"]
["V1 (down-regulated)","06/28/2013",23446634,"Chen Z","02/26/2013","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23446634","Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.","Red blood cell traits"," (up-regulated) to 16,485 African American individuals","9,692 African American individuals, 21,020 European ancestry individuals, 14,088 Japanese ancestry individuals","16p13.3",16,310380,"ITFG3, LUCL7, NPRL3, POLR3K, RPL2B, MPG, NME4, DECR, RHOT2, LMF1,WDR90","- ",null,null,83986,null,null,"rs13335629-A","rs13335629",0,13335629,"intron",0,0.134,4e-22,21.397940008672,"(MCV, AA)",0.65,"[0.52-0.78] fL decrease","Affymetrix & Illumina [NR]","N"]
["V1 (down-regulated)","06/06/2013",23417110,"Tin A","02/16/2013","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23417110","Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin.","Beta-2 microglubulin plasma levels","6,728 European ancestry individuals",null,"12q24.12",12,111884608,"SH2B3, ATXN2","- ",null,null,10019,null,null,"rs3184504-C","rs3184504",0,3184504,"missense",0,0.49,3e-08,7.52287874528033,null,0.02,"[0.012-0.028] unit decrease","Affymetrix [2.5 million] (Imputed)","N"]
["V1 (down-regulated)","05/14/2013",23393555,"Jensen RA","02/05/2013","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23393555","Genome-wide association study of retinopathy in individuals without diabetes.","Retinopathy in non-diabetics","19,411 European ancestry individuals","NR","22q11.21",22,20797289,"KLHL22","- ",null,null,84861,null,null,"rs5763911-T","rs5763911",0,5763911,"intron",0,0.96,6e-06,5.22184874961635,null,0.52,"[0.3-0.74] unit decrease","Illumina [2,675,979] (Imputed)","N"]
["V1 (down-regulated)","05/09/2013",23377640,"GENDEP Investigators","02/01/2013","Am J Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23377640 ","Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.","Major depressive disorder"," (up-regulated) to 2,256 European ancestry cases","NR","15q23",15,68597127,"PIAS1,CALML4,CLN6,FEM1B,ITGA11","- ",null,null,22801,null,null,"rs7174755-C","rs7174755",0,7174755,"intron",0,0.3690476,3e-07,6.52287874528033,"(% improvement - SSRI treated - 2 weeks)",0.2,"[0.13-0.28] unit decrease","Illumina & Affymetrix [1.2 million] (Imputed)","N"]
["V1 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"5q11.2",5,55322895,"IL6ST,ANKRD55",null,3572,727984,null,32.07,109.88,"rs17348299-C","rs17348299",0,17348299,null,1,0.836731980863373,2e-07,6.69897000433601,"(IGP17)",0.23,"[0.14-0.32] unit increase","Illumina [~2.5 Million] (Imputed)","N"]
["V1 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"5q11.2",5,55322895,"IL6ST,ANKRD55",null,3572,727984,null,32.07,109.88,"rs17348299-C","rs17348299",0,17348299,null,1,0.836657880517164,4e-06,5.39794000867203,"(IGP75)",0.21,"[0.12-0.29] unit decrease","Illumina [~2.5 Million] (Imputed)","N"]
["V1 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"5q11.2",5,55322895,"IL6ST,ANKRD55",null,3572,727984,null,32.07,109.88,"rs17348299-C","rs17348299",0,17348299,null,1,0.836659126892253,2e-09,8.69897000433601,"(IGP3)",0.27,"[0.18-0.35] unit decrease","Illumina [~2.5 Million] (Imputed)","N"]
["V1 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"5q11.2",5,55322895,"IL6ST,ANKRD55",null,3572,727984,null,32.07,109.88,"rs17348299-C","rs17348299",0,17348299,null,1,0.836731980863373,1e-10,10,"(IGP55)",0.29,"[0.2-0.37] unit decrease","Illumina [~2.5 Million] (Imputed)","N"]
["V1 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"5q11.2",5,55322895,"IL6ST,ANKRD55",null,3572,727984,null,32.07,109.88,"rs17348299-C","rs17348299",0,17348299,null,1,0.836660240071397,8e-06,5.09691001300805,"(IGP56)",0.2,"[0.11-0.29] unit increase","Illumina [~2.5 Million] (Imputed)","N"]
["V1 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"5q11.2",5,55322895,"IL6ST,ANKRD55",null,3572,727984,null,32.07,109.88,"rs17348299-C","rs17348299",0,17348299,null,1,0.836731980863373,1e-10,10,"(IGP57)",0.29,"[0.2-0.37] unit increase","Illumina [~2.5 Million] (Imputed)","N"]
["V1 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"5q11.2",5,55322895,"IL6ST,ANKRD55",null,3572,727984,null,32.07,109.88,"rs17348299-C","rs17348299",0,17348299,null,1,0.836731980863373,7e-11,10.1549019599857,"(IGP53)",0.29,"[0.2-0.38] unit increase","Illumina [~2.5 Million] (Imputed)","N"]
["V1 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"5q11.2",5,55322895,"IL6ST,ANKRD55",null,3572,727984,null,32.07,109.88,"rs17348299-C","rs17348299",0,17348299,null,1,0.836731980863373,1e-10,10,"(IGP13)",0.29,"[0.2-0.38] unit increase","Illumina [~2.5 Million] (Imputed)","N"]
["V1 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"5q11.2",5,55322895,"IL6ST,ANKRD55",null,3572,727984,null,32.07,109.88,"rs17348299-C","rs17348299",0,17348299,null,1,0.836731980863373,3e-10,9.52287874528033,"(IGP43)",0.28,"[0.19-0.37] unit decrease","Illumina [~2.5 Million] (Imputed)","N"]
["V1 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"5q11.2",5,55322895,"IL6ST,ANKRD55",null,3572,727984,null,32.07,109.88,"rs17348299-C","rs17348299",0,17348299,null,1,0.836804684351315,2e-06,5.69897000433601,"(IGP69)",0.21,"[0.12-0.3] unit decrease","Illumina [~2.5 Million] (Imputed)","N"]
["V1 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"5q11.2",5,55322895,"IL6ST,ANKRD55",null,3572,727984,null,32.07,109.88,"rs17348299-C","rs17348299",0,17348299,null,1,0.836669484361037,2e-06,5.69897000433601,"(IGP74)",0.21,"[0.13-0.3] unit decrease","Illumina [~2.5 Million] (Imputed)","N"]
["V1 (down-regulated)","04/04/2013",23319000,"Luykx JJ","01/15/2013","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23319000 ","Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.","Metabolite levels (5-HIAA)"," (up-regulated) to 398 European individuals","NR","17p13.3",17,2145193,"SRR, SMG6, AJ276246","- ",null,null,23293,null,null,"rs11078884-C","rs11078884",0,11078884,"intron",0,"NR",3e-06,5.52287874528033,null,0.22,"unit increase","Illumina [5,767,231] (Imputed)","N"]
["V1 (down-regulated)","04/04/2013",23319000,"Luykx JJ","01/15/2013","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23319000 ","Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.","Metabolite levels (HVA/MHPG ratio)"," (up-regulated) to 398 European individuals","NR","16p13.3",16,5003074,"SEC14L5, PPL",null,5493,9717,null,15.94,5.24,"rs34924084-A","rs34924084",0,34924084,null,1,"NR",2e-06,5.69897000433601,null,0.3,"unit increase","Illumina [5,767,231] (Imputed)","N"]
["V1 (down-regulated)","03/28/2013",23291589,"Lu Y","01/06/2013","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23291589 ","Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.","Corneal structure","13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals","NR","15q25.3",15,85825567,"AKAP13",null,100216542,100151676,null,29.08,107.49,"rs6496932-A","rs6496932",0,6496932,null,1,0.2,7e-13,12.1549019599857,null,0.11,"[0.071-0.149] unit decrease","Illumina & Affymetrix [~1 Million] (Imputed)","N"]
["V1 (down-regulated)","03/15/2013",23263486,"Kottgen A","12/23/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263486","Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.","Urate levels","49,825 European ancestry men, 60,522 European ancestry women"," (up-regulated) to 32,813 European ancestry individuals","12q24.12",12,112007756,"ATXN2, PTPN11","- ",null,null,6311,null,null,"rs653178-T","rs653178",0,653178,"intron",0,0.51,7e-12,11.1549019599857,null,0.04,"[0.025-0.045] mg/dl decrease","Affymetrix, Illumina, Perlegen [2,450,547] (imputed)","N"]
["V1 (down-regulated)","03/15/2013",23263486,"Kottgen A","12/23/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263486","Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.","Urate levels","49,825 European ancestry men, 60,522 European ancestry women"," (up-regulated) to 32,813 European ancestry individuals","5q11.2",5,55811092,"ANKRD55",null,441073,4214,null,10.15,299.81,"rs456867-T","rs456867",0,456867,null,1,0.17,3e-06,5.52287874528033,"(women)",0.04,"[0.022-0.054] mg/dl decrease","Affymetrix, Illumina, Perlegen [2,450,547] (imputed)","N"]
["V1 (down-regulated)","03/15/2013",23263863,"Li J","12/20/2012","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263863","GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.","Hematology traits","7,943 African American children, 6,234 European ancestry children","NR","6p21.33",6,31058340,"MUC21, HCG22, C6orf15, CDSN, PSORS1C1, PSORS1C2, CCHCR1",null,285834,29113,null,30.67,20.66,"rs3130544-A","rs3130544",0,3130544,null,1,"NR",5e-07,6.30102999566398,"(WBC)",0.02,"[0.011-0.026] unit decrease","Illumina [544,917]","N"]
["V1 (down-regulated)","03/19/2013",23222517,"van der Harst P","12/05/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23222517","Seventy-five genetic loci influencing the human red blood cell.","Red blood cell traits","62,553 European ancestry individuals, 9,308 South Asian ancestry individuals","63,506 European ancestry individuals","12q24.12",12,111884608,"SH2B3, ATXN2","- ",null,null,10019,null,null,"rs3184504-T","rs3184504",0,3184504,"missense",0,0.48,4e-19,18.397940008672,"(EA, Hgb)",0.05,"[0.039-0.063] unit increase","Illumina, Affymetrix & Perlegen [2,711,806] imputed","N"]
["V1 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","16p11.1",16,34682193,"TP53TG3B",null,100129351,100887740,null,57.78,298.7,"rs62057608-A","rs62057608",0,62057608,null,1,0.028,4e-06,5.39794000867203,"(Diet fat )",0.03,"[NR]  g/d increase","Illumina [899,892]","N"]
["V1 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","18q11.2",18,23393104,"SS18",null,25925,6760,null,460.89,203.11,"rs7231041-G","rs7231041",0,7231041,null,1,0.174,2e-06,5.69897000433601,"(Moderate activity )",0.04,"[NR]  min/d increase","Illumina [899,892]","N"]
["V1 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","18q11.2",18,23393104,"SS18",null,25925,6760,null,460.89,203.11,"rs7231041-G","rs7231041",0,7231041,null,1,0.174,5e-06,5.30102999566398,"(Moderate activity )",0.03,"[NR]  %awake time increase","Illumina [899,892]","N"]
["V1 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","18q11.2",18,23393104,"SS18",null,25925,6760,null,460.89,203.11,"rs7231041-G","rs7231041",0,7231041,null,1,0.174,3e-06,5.52287874528033,"(Moderate&vigorous activity )",0.03,"[NR]  min/d increase","Illumina [899,892]","N"]
["V1 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","4p14",4,38465471,"FLJ13197",null,23216,79667,null,324.68,148.85,"rs4615179-A","rs4615179",0,4615179,null,1,0.098,8e-06,5.09691001300805,"(Urinary free epinephrine )",0.02,"[NR]  nmol/d increase","Illumina [899,892]","N"]
["V1 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","21q22.12",21,37013621,"SETD4",null,266693,768219,null,41.07,79.39,"rs12483148-G","rs12483148",0,12483148,null,1,0.038,5e-06,5.30102999566398,"(DBP )",0.03,"[NR]  mmHg increase","Illumina [899,892]","N"]
["V1 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","10q24.2",10,100583915,"HPSE2","- ",null,null,60495,null,null,"rs2801405-G","rs2801405",0,2801405,"intron",0,0.33,9e-06,5.04575749056067,"(Urinary free norepinephrine )",0.03,"[NR]  nmol/d increase","Illumina [899,892]","N"]
["V1 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","9q21.33",9,86944425,"SLC28A3","- ",null,null,64078,null,null,"rs12000457-A","rs12000457",0,12000457,"intron",0,0.04,4e-06,5.39794000867203,"(Sleep duration )",0.03,"[NR]  min/d increase","Illumina [899,892]","N"]
["V1 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","19p13.2",19,10798904,"ILF3","- ",null,null,3609,null,null,"rs2569507-G","rs2569507",0,2569507,"intron",0,0.406,7e-06,5.15490195998574,"(TG )",0.02,"[NR]  mg/dL increase","Illumina [899,892]","N"]
["V1 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","6p24.1",6,12510127,"RPL15P3",null,1906,653232,null,212.7,4.18,"rs12198798-G","rs12198798",0,12198798,null,1,0.114,1e-06,5.99999999999999,"(BMI z-score change )",0.04,"[NR]  SD/y increase","Illumina [899,892]","N"]
["V1 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","10q25.3",10,116199175,"ABLIM1","- ",null,null,3983,null,null,"rs941853-A","rs941853",0,941853,"intron",0,0.189,6e-06,5.22184874961635,"(BMI z-score change )",0.03,"[NR]  SD/y increase","Illumina [899,892]","N"]
["V1 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","15q26.1",15,89617081,"ABHD2",null,390634,692147,null,112.74,61.22,"rs420017-A","rs420017",0,420017,null,1,0.336,8e-06,5.09691001300805,"(BMR )",0.04,"[NR]  kcal/d increase","Illumina [899,892]","N"]
["V1 (down-regulated)","02/14/2013",23192594,"Velez Edwards DR","11/29/2012","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23192594 ","Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.","Waist-to-hip circumference ratio (interaction)","8,203 African American women, 3,484 Hispanic ancestry women","NR","9q21.33",9,87186405,"SLC28A3, NTRK2",null,64078,4915,null,202.99,97.06,"rs4877280-T","rs4877280",0,4877280,null,1,"NR",9e-06,5.04575749056067,"(Recreational physical activity)",0.04,"[NR] unit increase","Affymetrix [706,791]","N"]
["V1 (down-regulated)","01/30/2013",23144326,"Kim DK","11/09/2012","Am J Respir Crit Care Med","http://www.ncbi.nlm.nih.gov/pubmed/23144326","Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.","Chronic obstructive pulmonary disease-related biomarkers"," (up-regulated) to 1,951 European ancestry smokers","NR","6p21.33",6,31107187,"PSORS1C1, CCHCR1","- ",null,null,"170679;170680",null,null,"rs1265093-A","rs1265093",0,1265093,"intron;nearGene-5",0,0.26,6e-09,8.22184874961635,"(SP-D)","NR","NR","Illumina (588,352)","N"]
["V1 (down-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","11q12.2",11,60776209,"CD6,CD5,PTGDR2","- ",null,null,923,null,null,"rs11230563-C","rs11230563",0,11230563,"missense",0,0.654,9e-13,12.0457574905606,null,1.09,"[1.053-1.118] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V1 (down-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","12q15",12,68500075,"IFNG,IL26,IL22",null,100271520,3458,null,104.75,48.48,"rs7134599-A","rs7134599",0,7134599,null,1,0.378,9e-32,31.0457574905606,null,1.1,"[1.064-1.128] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V1 (down-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","16p11.2",16,28517709,"RABEP2,IL27,EIF3C,SULT1A1,SULT1A2,N (up-regulated)R1","- ",null,null,246778,null,null,"rs26528-C","rs26528",0,26528,"intron",0,0.451,1e-21,21,null,1.1,"[1.067-1.13] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V1 (down-regulated)","01/11/2013",23118974,"Candille SI","10/31/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23118974","Genome-wide association studies of quantitatively measured skin, hair, and eye pigmentation in four European populations.","Eye color","175 European ancestry individuals","293 European ancestry individuals","15q13.1",15,28530182,"HERC2, OCA2","- ",null,null,8924,null,null,"rs1667394-C","rs1667394",0,1667394,"intron",0,0.28,2e-20,19.698970004336,"(Eye color)",0.35,"[0.28-0.42] unit increase","Illumina [313,763]","N"]
["V1 (down-regulated)","01/10/2013",23065704,"Amin Al Olama A","10/12/2012","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23065704","A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease.","Prostate cancer","5,132 European ancestry non-aggressive cases, 5,953 European ancestry aggressive cases, 11,463 European ancestry controls","22,387 European ancestry non-aggressive cases, 2,008 European ancestry aggressive cases,  (up-regulated) to 24,726 European ancestry controls","19q13.2",19,41985587,"ATP5SL, CEACAM21","- ",null,null,100505495,null,null,"rs11672691 -G","rs11672691",0,11672691,"intron",0,"NR",2e-12,11.698970004336,"(All)",1.08,"[1.04-1.12] ","Illumina [~2.6 million] (imputed)","N"]
["V1 (down-regulated)","01/10/2013",23065704,"Amin Al Olama A","10/12/2012","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23065704","A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease.","Prostate cancer","5,132 European ancestry non-aggressive cases, 5,953 European ancestry aggressive cases, 11,463 European ancestry controls","22,387 European ancestry non-aggressive cases, 2,008 European ancestry aggressive cases,  (up-regulated) to 24,726 European ancestry controls","19q13.2",19,41985587,"ATP5SL, CEACAM21","- ",null,null,100505495,null,null,"rs11672691-G","rs11672691",0,11672691,"intron",0,"NR",1e-08,8,"(Aggressive)",1.11,"[1.02-1.20] ","Illumina [~2.6 million] (imputed)","N"]
["V1 (down-regulated)","01/16/2013",23064961,"Shaffer JR","10/11/2012","J Dent Res","http://www.ncbi.nlm.nih.gov/pubmed/23064961","GWAS of dental caries patterns in the permanent dentition.","Dental caries","920 European ancestry individuals","NR","13q21.32",13,67696145,"PCDH9","- ",null,null,5101,null,null,"rs2875517-?","rs2875517",0,2875517,"intron",0,"NR",3e-06,5.52287874528033,"(DMFS3)","NR","NR","Illumina [518,997]","N"]
["V1 (down-regulated)","12/06/2012",23006423,"Niu N M D Ph D","09/24/2012","BMC Cancer","http://www.ncbi.nlm.nih.gov/pubmed/23006423 ","Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.","Response to taxane treatment (docetaxel)","96 African American lymphoblastoid cell lines, 96 European ancestry lymphoblastoid cell lines, 96 Han Chinese lymphoblastoid cell lines","NR","17q21.33",17,48289070,"COL1A1 ",null,1277,100131823,null,10.07,24.14,"rs2586502-?  ","rs2586502 ",0,2586502,null,1,"NR",1e-06,5.99999999999999,null,"NR","NR","Affymetrix & Illumina [~1.3 Million]","N"]
["V1 (down-regulated)","01/15/2013",23225573,"Buck D","09/08/2012","Ann Neurol","http://www.ncbi.nlm.nih.gov/pubmed/23225573","Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis.","IgG levels","229 European ancestry multiple sclerosis cases","409 European ancestry multiple sclerosis cases","14q32.33",14,106232585,"IGHG3, IGHG1, IGHG2","- ",null,null,3502,null,null,"rs10136766-A","rs10136766",0,10136766,null,0,0.27,8e-16,15.096910013008,null,0.23,"[NR] unit increase","Illumina [526,014]","N"]
["V1 (down-regulated)","11/20/2012",22959728,"Ahmeti KB","09/05/2012","Neurobiol Aging","http://www.ncbi.nlm.nih.gov/pubmed/22959728","Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.","Amyotrophic lateral sclerosis (age of onset)","4,243 European ancestry cases","NR","12q15",12,70690085,"CNOT2","- ",null,null,4848,null,null,"rs2904524-T","rs2904524",0,2904524,"intron",0,0.13,5e-06,5.30102999566398,"(Joint)","NR","NR","Illumina [254,145]","N"]
["V1 (down-regulated)","11/05/2012",22952603,"Hart AB","08/28/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/22952603","Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).","Response to amphetamines","1 American Indian ancestry individual, 18 African American/Afro-Caribbean ancestry individuals, 10 East Asian and South Asian ancestry individuals, 325 European ancestry individuals, 17 Latin American ancestry individuals, 6 other ancestry individuals, 4 individuals","NR","10q11.23",10,52119297,"SGMS1","- ",null,null,259230,null,null,"rs2574975-?","rs2574975",0,2574975,"intron",0,"NR",5e-06,5.30102999566398,"(SF6)","NR","NR","Affymetrix [5,476,100] (imputed)","N"]
["V1 (down-regulated)","10/23/2012",22911880,"Boraska V","08/22/2012","Am J Med Genet B Neuropsychiatr Genet","http://www.ncbi.nlm.nih.gov/pubmed/22911880","Genome-wide association analysis of eating disorder-related symptoms, behaviors, and personality traits.","Eating disorders"," (up-regulated) to 2,567 European ancestry individuals"," (up-regulated) to 767 European ancestry cases,  (up-regulated) to 486  European ancestry controls","15q21.1",15,47892298,"SEMA6D","- ",null,null,80031,null,null,"rs1898111-A","rs1898111",0,1898111,"intron",0,0.837,8e-06,5.09691001300805,"(OCPD)",1.15,"[1.08-1.22] ","Illumina [283,744]","N"]
["V1 (down-regulated)","09/27/2012",22808956,"Lyons PA","07/19/2012","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/22808956","Genetically distinct subsets within ANCA-associated vasculitis.","Antineutrophil cytoplasmic antibody-associated vasculitis ","914 European ancestry cases, 5,259 European ancestry controls","1,454 European ancestry cases, 1,666 European ancestry controls","6p21.32",6,33069893,"HLA-DP, COL11A2",null,646702,394214,null,8.8,1.58,"rs3117242-?","rs3117242",0,3117242,null,1,"NR",1e-71,71,null,3.67,"[NR] ","Affymetrix [NR]","N"]
["V1 (down-regulated)","09/18/2012",22797727,"Okada Y","07/15/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22797727","Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.","Renal function-related traits (eGRFcrea)","42,451 Japanese, Chinese, Malay, and Indian ancestry individuals","19,636 Japanese, Chinese, and Korean ancestry individuals","6q25.2",6,154986664,"CNKSR3, RBM16",null,100270990,22828,null,59.6,67.85,"rs9397738-G","rs9397738",0,9397738,null,1,0.22,5e-06,5.30102999566398,null,0,"[0.0021-0.0057] ml/min/1.73m2 decrease","Affymetrix & Illumina [2,353,587] (imputed)","N"]
["V1 (down-regulated)","08/20/2012",22747683,"Eriksson N","06/30/2012","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/22747683","Genetic variants associated with breast size also influence breast cancer risk.","Breast size","16,175 European ancestry women","NR","7q31.1",7,111642646,"ZNF277","- ",null,null,9732,null,null,"rs61159171-T","rs61159171",0,61159171,"intron",0,0.348,6e-06,5.22184874961635,null,0.08,"[0.042-0.108] c (up-regulated) size decrease","Illumina [7,422,970] (imputed)","N"]
["V1 (down-regulated)","08/20/2012",22747683,"Eriksson N","06/30/2012","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/22747683","Genetic variants associated with breast size also influence breast cancer risk.","Breast size","16,175 European ancestry women","NR","2q14.2",2,120513133,"EPB41L5",null,100128117,5775,null,55.37,4.07,"rs13401620-A","rs13401620",0,13401620,null,1,0.224,2e-06,5.69897000433601,null,0.1,"[0.056-0.134] c (up-regulated) size decrease","Illumina [7,422,970] (imputed)","N"]
["V1 (down-regulated)","08/08/2012",22694956,"Cipriani V","06/13/2012","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/22694956","Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3.","Age-related macular degeneration","893 European ancestry cases, 2,199 European ancestry controls","1,411 European ancestry cases, 1,431 European ancestry controls","6p21.33",6,32074804,"TNXB","- ",null,null,7148,null,null,"rs12153855-C","rs12153855",0,12153855,"intron",0,0.011,1e-09,8.99999999999999,null,1.44,"[1.28-1.63] ","Illumina [2,272,849] (imputed)","N"]
["V1 (down-regulated)","08/14/2012",22688191,"Bergen SE","06/12/2012","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22688191","Genome-wide association study in a Swedish population yields s (up-regulated)port for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.","Bipolar disorder","836 European ancestry bipolar disorder cases, 2,535 European ancestry controls","NR","12q23.3",12,108742820,"CMKLR1",null,1240,11153,null,9.73,166.23,"rs17040430-T","rs17040430",0,17040430,null,1,"NR",9e-07,6.04575749056067,null,1.89,"[NR] ","Affymetrix [745,006]","N"]
["V1 (down-regulated)","07/11/2012",22561518,"Jin Y","05/06/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22561518","Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.","Vitiligo","418 European ancestry cases, 2,810 European ancestry controls        ","1,377 European ancestry cases, 1,284 European ancestry controls","15q13.1",15,28356859,"OCA2, HERC2","- ",null,null,8924,null,null,"rs1129038-C","rs1129038",0,1129038,"UTR-3",0,0.27,4e-08,7.39794000867203,null,1.22,"[NR] ","Illumina [495,821]","N"]
["V1 (down-regulated)","04/11/2013",22504420,"Estrada K","04/15/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22504420","Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.","Bone mineral density"," (up-regulated) to 32,961 European and East Asian ancestry individuals"," (up-regulated) to 50,933 European and East Asian ancestry individuals","10q22.3",10,79401316,"KCNMA1",null,3778,100129156,null,3.74,96.66,"rs7071206-T","rs7071206",0,7071206,null,1,0.78,5e-19,18.3010299956639,"(LSBMD)",0.06,"[NR] unit decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (down-regulated)","05/25/2012",22493691,"Eriksson N","04/06/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/22493691","Novel associations for hypothyroidism include known autoimmune risk loci.","Hypothyroidism","3,736 European ancestry cases, 35,546 European ancestry controls","NR","12q24.12",12,111884608,"SH2B3, ATXN2, LOC100101246, BRAP, NAA25, C12orf51, PTPN11","- ",null,null,10019,null,null,"rs3184504-T","rs3184504",0,3184504,"missense",0,0.502,3e-12,11.5228787452803,null,1.2,"[1.14-1.27] ","Illumina [870,065]","N"]
["V1 (down-regulated)","04/27/2012",22424883,"Imboden M","03/15/2012","J Allergy Clin Immunol","http://www.ncbi.nlm.nih.gov/pubmed/22424883","Genome-wide association study of lung function decline in adults with and without asthma.","Pulmonary function decline","1,441 European ancestry asthma cases, 2,677 European ancestry controls","1,160 European ancestry asthma cases, 10,858 European ancestry controls","13q21.32",13,66356341,"PCDH9",null,6771,387933,null,471.05,5.34,"rs17077331-?","rs17077331",0,17077331,null,1,"NR",4e-06,5.39794000867203,"(FEV1/FVC decline in non-asthmatics)",0.5,"[0.29-0.72] unit increase","Illumina [~2.5 million] (imputed)","N"]
["V1 (down-regulated)","04/03/2012",22412388,"Kenny EE","03/08/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22412388","A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.","Crohn's disease","737 Ashkenazi Jewish cases, 2,257  Ashkenazi Jewish controls","971 Ashkenazi Jewish cases, 2,124 Ashkenazi Jewish controls","10q24.2",10,101292390,"NKX2-3, SLC25A28, GOT1, ENTPD7, CNNM1, COX15, CUTC","- ",null,null,159296,null,null,"rs11190141-C","rs11190141",0,11190141,"nearGene-5",0,0.739,5e-07,6.30102999566398,null,1.34,"[1.25-1.43] ","Affyemtrix & Illumina [1,060,934] (imputed)","N"]
["V1 (down-regulated)","04/03/2012",22412388,"Kenny EE","03/08/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22412388","A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.","Crohn's disease","737 Ashkenazi Jewish cases, 2,257  Ashkenazi Jewish controls","971 Ashkenazi Jewish cases, 2,124 Ashkenazi Jewish controls","2p15",2,62713533,"TMEM17, EHBP1, CPAMD8, AK3",null,10678,200728,null,261.67,13.82,"rs6545946-C","rs6545946",0,6545946,null,1,0.77,7e-09,8.15490195998574,null,1.16,"[1.06-1.27] ","Affyemtrix & Illumina [1,060,934] (imputed)","N"]
["V1 (down-regulated)","04/20/2012",22451204,"Pankratz N","03/01/2012","Ann Neurol","http://www.ncbi.nlm.nih.gov/pubmed/22451204","Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.","Parkinson's disease","4,238 European ancestry cases, 4,239 European ancestry controls","3,738 European ancestry cases, 2,111 European ancestry controls","6q25.2",6,154726988,"CNKSR3","- ",null,null,154043,null,null,"rs2275336-?","rs2275336",0,2275336,"UTR-3",0,"NR",9e-07,6.04575749056067,null,1.36,"[NR] ","Illumina [2.5 million] (imputed)","N"]
["V1 (down-regulated)","03/14/2012",22331829,"Chasman DI","02/13/2012","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/22331829","Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (J (up-regulated)ITER) trial.","Response to statin therapy (LDL-C)","6,989 European ancestry individuals","NR","9q22.1",9,91540059,"C9orf47, S1PR3, SHC3",null,100423015,100128911,null,179.24,45.67,"rs1875620-?","rs1875620",0,1875620,null,1,"NR",7e-07,6.15490195998574,"(absolute LDL-C reduction)",2.8,"[1.62-3.98] mg/dL increase","Illumina [814,418]","N"]
["V1 (down-regulated)","02/21/2012",22291604,"Okada Y","01/26/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22291604","A genome-wide association study identified AFF1 as a susceptibility locus for systemic l (up-regulated)us eyrthematosus in Japanese.","Systemic l (up-regulated)us erythematosus","891 Japanese ancestry cases, 3,384 Japanese ancestry controls","1,387 Japanese ancestry cases, 28,564 Japanese ancestry controls","4q21.3",4,87958395,"AFF1","- ",null,null,4299,null,null,"rs340630-A","rs340630",0,340630,"intron",0,0.52,8e-09,8.09691001300805,null,1.21,"[1.14-1.30] ","Illumina [430,797]","N"]
["V1 (down-regulated)","03/31/2012",22219177,"Tao S","01/04/2012","Carcinogenesis","http://www.ncbi.nlm.nih.gov/pubmed/22219177","A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.","Prostate cancer (gene x gene interaction)","4,723 cases, 4,792 controls","NR","10q25.3",10,116327550,"ABLIM1","- ",null,null,3983,null,null,"rs10885582-?","rs10885582",0,10885582,"intron",0,"NR",4e-06,5.39794000867203,"(rs1447295)",1.37,"[1.20-1.59] ","Affymetrix & Illumina [1,117,531] (imputed)","N"]
["V1 (down-regulated)","01/28/2012",22197932,"Paternoster L","12/25/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22197932","Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.","Atopic dermatitis","5,606 European ancestry cases, 20,565 European ancestry controls","5,419 European ancestry cases, 19,833 European ancestry controls","6p21.33",6,31499603,"BAT1","- ",null,null,"7919;100532737",null,null,"rs3853601-G","rs3853601",0,3853601,"intron;intron",0,0.12,2e-06,5.69897000433601,null,1.13,"[1.08-1.19] ","Afftmetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (down-regulated)","11/16/2012",22139419,"Gieger C","11/30/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/22139419","New gene functions in megakaryopoiesis and platelet formation.","Platelet counts","48,666 individuals of European ancestry"," (up-regulated) to 18,838 individuals of European ancestry","17p13.2",17,4836381,"GP1BA","- ",null,null,2811,null,null,"rs6065-T","rs6065",0,6065,"missense",0,"NR",3e-11,10.5228787452803,null,4.19,"[2.96-5.43] 10^9/l increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (down-regulated)","11/18/2011",22001757,"Chambers JC","10/16/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22001757","Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.","Liver enzyme levels (alkaline phosphatase)"," (up-regulated) to 52,350 European ancestry individuals,  (up-regulated) to 8,739 Indian Asian individuals","NR","9q31.1",9,104223233,"ALDOB, C9orf125",null,229,84302,null,25.17,14.38,"rs10819937-C","rs10819937",0,10819937,null,1,0.17,1e-09,8.99999999999999,null,2.5,"[1.40-3.60] % increase","Affymetrix, Illumina, and Perlegen [~2.6 million] (imputed)","N"]
["V1 (down-regulated)","11/08/2011",21998595,"N'Diaye A","10/06/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21998595","Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.","Height","20,427 African ancestry individuals"," (up-regulated) to 16,436 African American individuals","2p16.1",2,55516323,"CCDC88A","- ",null,null,55704,null,null,"rs2589113-T","rs2589113",0,2589113,"UTR-3",0,0.48,2e-08,7.69897000433601,null,0.04,"[0.028-0.060] unit increase","Affymetrix & Illumina [3,310,998] (imputed)","N"]
["V1 (down-regulated)","10/06/2011",21935397,"Paternoster L","09/15/2011","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/21935397","Genome-wide population-based association study of extremely overweight young adults--the GOYA study.","Obesity (extreme)","2,633 European ancestry extremely obese adults, 2,740 European ancestry controls","29,181 European ancestry individuals","1q32.2",1,209727257,"CAMK1G",null,406988,57172,null,121.67,29.79,"rs12130212-T","rs12130212",0,12130212,null,1,"NR",2e-06,5.69897000433601,null,"NR","NR","Illumina [545,349]","N"]
["V1 (down-regulated)","10/07/2011",21912425,"Tohkin M","09/13/2011","Pharmacogenomics J","http://www.ncbi.nlm.nih.gov/pubmed/21912425","A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients.","Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN)","14 Japanese ancestry cases, 991 Japanese ancestry controls","NR","6p21.33",6,31505480,"BAT1, HCP5, MICC, PPIAP9, PSORS1C1, POLR2LP, CCHCR1, TCF19, POU5F1, HLA-C, HCP5, PSORS1C3, HLA-B*5801","- ",null,null,"7919;692233;100532737",null,null,"rs2734583-?","rs2734583",0,2734583,"intron;nearGene-5;intron",0,0.0055,2e-08,7.69897000433601,null,66.8,"[19.8-225.0] ","Illumina [890,321]","N"]
["V1 (down-regulated)","10/11/2011",21909110,"Wain LV","09/11/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21909110","Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.","Blood pressure","74,064 European ancestry individuals","48,607 European ancestry individuals","12q24.12",12,112007756,"ATXN2","- ",null,null,6311,null,null,"rs653178-T","rs653178",0,653178,"intron",0,0.59,7e-20,19.1549019599857,"(Mean Arterial Pressure)",0.43,"[0.34-0.52] mmHg decrease","Affymetrix, Illumina, and Perlegen [NR] (imputed)","N"]
["V1 (down-regulated)","02/10/2012",21931564,"Nicholson G","09/08/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21931564","A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.","Metabolite levels","142 European ancestry female twins","202 European ancestry individuals","2p13.1",2,73743982,"ALMS1, NAT8, TPRKB, DUSP11","- ",null,null,7840,null,null,"rs9309473-G","rs9309473",0,9309473,"intron",0,"NR",1e-11,11,"(N-ACu)",1.1,"[0.85-1.35] unit increase","Illumina [2,541,644] (imputed)","N"]
["V1 (down-regulated)","02/24/2012",21886157,"Suhre K","08/31/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21886157","Human metabolic individuality in biomedical and pharmaceutical research.","Metabolic traits","2,820 European ancestry individuals","NR","22q11.21",22,18972450,"PRODH","- ",null,null,"26220;100996369",null,null,"rs2023634-G","rs2023634",0,2023634,"intron;intron",0,0.091,2e-22,21.698970004336,"(proline + 5 other traits)",0.11,"[NR] unit increase","Affmyetrix & Illumina [534,665] ","N"]
["V1 (down-regulated)","09/27/2011",21873549,"Strawbridge RJ","08/26/2011","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/21873549","Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.","Proinsulin levels","10,701 European ancestry nondiabetic adults","16,378 European ancestry nondiabetic adults","17p13.3",17,2262703,"SGSM2","- ",null,null,9905,null,null,"rs4790333-T","rs4790333",0,4790333,"intron",0,0.45,3e-09,8.52287874528033,null,"NR","NR","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (down-regulated)","10/24/2012",21833088,"Sawcer S","08/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21833088","Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.","Multiple sclerosis","9,772 European ancestry cases, 16,849 European ancestry controls","4,218 European ancestry cases, 7,296 European ancestry controls","11q12.2",11,60832282,"CD5, CD6",null,100189469,921,null,68.71,37.65,"rs650258-G","rs650258",0,650258,null,1,"NR",2e-11,10.698970004336,null,1.12,"[1.1-1.13] ","Illumina [465,434]","N"]
["V1 (down-regulated)","09/08/2011",21810271,"Antoni G","08/02/2011","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/21810271","Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels.","vWF and FVIII levels","1,624 European ancestry individuals","NR","2p23.1",2,30526780,"LBH",null,81606,253558,null,43.88,143.34,"rs6708166-A","rs6708166",0,6708166,null,1,0.4,1e-06,5.99999999999999,"(FVIII activity)",0.17,"[0.09-0.25] IU/dL decrease","Illumina [442,728]","N"]
["V1 (down-regulated)","09/06/2011",21810746,"Chantarangsu S","08/01/2011","Clin Infect Dis","http://www.ncbi.nlm.nih.gov/pubmed/21810746","Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash.","Nevirapine-induced rash","72 Thai nevirapine-induced rash patients, 77 Thai nevirapine-tolerant rash patients","88 Thai nevirapine-induced rash patients, 145 nevirapine-tolerant patients","6p21.33",6,31118019,"CCHCR1","- ",null,null,54535,null,null,"rs1265112-G","rs1265112",0,1265112,"intron",0,0.06,1e-08,8,null,4.36,"[2.58-7.36] ","Illumina [499,730]","N"]
["V1 (down-regulated)","09/03/2011",21804547,"Dobbins SE","07/31/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21804547","Common variation at 10p12.31 near MLLT10 influences meningioma risk.","Meningioma ","859 European ancestry cases, 704 European ancestry controls","774 European ancestry cases, 1,764 European ancestry controls","10p12.31",10,21830104,"MLLT10","- ",null,null,8028,null,null,"rs11012732-A","rs11012732",0,11012732,"intron",0,0.32,2e-14,13.698970004336,null,1.46,"[1.32-1.61] ","Illumina [270,875]","N"]
["V1 (down-regulated)","09/01/2011",21829377,"Lemaitre RN","07/28/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21829377","Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.","Phospholipid levels (plasma)","8,866 European ancestry individuals","NR","6p21.33",6,32071017,"TNXB","- ",null,null,7148,null,null,"rs3117181-C","rs3117181",0,3117181,"intron",0,"NR",5e-07,6.30102999566398,"(DPA)",0.02,"[NR] % increase","Affymetrix & Illumina [NR]","N"]
["V1 (down-regulated)","08/12/2011",21768215,"Tin A","07/18/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21768215","Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele.","Urate levels","8,651 African American individuals","1,996 African American individuals","11q13.1",11,64546391,"MEN1,SF1,MAP4K2,PYGM,RASGRP2,CDC42BPG,NRXN2","- ",null,null,7536,null,null,"rs606458-T","rs606458",0,606458,"nearGene-5",0,0.35,6e-11,10.2218487496163,"(AA)",0.18,"[NR] mg/dl decrease","Affymetrix [NR] (imputed)","N"]
["V1 (down-regulated)","08/22/2011",21743467,"Kote-Jarai Z","07/10/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21743467","Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.","Prostate cancer","6,621 European ancestry cases, 6,939 European ancestry controls","22,957 European ancestry cases, 23,234 European ancestry controls, 285 Japanese cases, 298 Japanese controls, 135 Chinese cases, 135 Chinese controls, 112 African American cases, 298 African American controls, 7,140 cases, 5,455 controls","6p21.33",6,31118511,"CCHCR1","- ",null,null,54535,null,null,"rs130067-G","rs130067",0,130067,"missense",0,0.21,3e-08,7.52287874528033,null,1.05,"[1.02-1.09] ","NR [2.6 million] (imputed)","N"]
["V1 (down-regulated)","07/19/2011",21708048,"Jiao H","06/28/2011","BMC Med Genomics","http://www.ncbi.nlm.nih.gov/pubmed/21708048","Genome wide association study identifies KCNMA1 contributing to human obesity.","Obesity","164 morbidly obese European ancestry individuals, 163 lean European ancestry individuals","4,674 morbidly obese European ancestry individuals, 5,663 lean European ancestry individuals","10q22.3",10,78646536,"KCNMA1","- ",null,null,3778,null,null,"rs2116830-G","rs2116830",0,2116830,"intron",0,0.8,3e-10,9.52287874528033,null,1.26,"[1.12-1.41] ","Affymetrix [406,177]","N"]
["V1 (down-regulated)","07/13/2011",21700265,"Kullo IJ","06/22/2011","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/21700265","Complement receptor 1 gene variants are associated with erythrocyte sedimentation rate.","Erythrocyte sedimentation rate","1,979 European ancestry individuals","5,628 European ancestry individuals","1p36.11",1,25570081,"C1orf63","- ",null,null,57035,null,null,"rs1043879-?","rs1043879",0,1043879,"missense",0,"NR",2e-09,8.69897000433601,null,0.09,"[NR] unit decrease","Illumina [476,395]","N"]
["V1 (down-regulated)","07/08/2011",21682944,"Alkelai A","06/20/2011","Int J Neuropsychopharmacol","http://www.ncbi.nlm.nih.gov/pubmed/21682944","DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population.","Schizophrenia","331 Jewish-Israeli family members","189 Arab-Israeli individuals, 57 Arab-Israeli nuclear families","19q13.2",19,42066279,"ATP5SL, CEACAM21",null,91405,90273,null,37.97,16.25,"rs4803480-A","rs4803480",0,4803480,null,1,0.13,1e-07,7,null,"NR","NR","Illumina [311,517]","N"]
["V1 (down-regulated)","06/25/2011",21654844,"Briggs FB","06/09/2011","Genes Immun","http://www.ncbi.nlm.nih.gov/pubmed/21654844","Genome-wide association study of severity in multiple sclerosis.","Multiple sclerosis","1,470 European ancestry cases","NR","4q31.3",4,154154000,"TRIM2","- ",null,null,23321,null,null,"rs12644284-?","rs12644284",0,12644284,"intron",0,0.67,4e-06,5.39794000867203,"(Extreme)",2.04,"[NR] ","Affymetrix [2,110,417] (imputed)","N"]
["V1 (down-regulated)","05/27/2011",21546767,"Murea M","05/05/2011","Am J Nephrol","http://www.ncbi.nlm.nih.gov/pubmed/21546767","Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.","Dialysis-related mortality","610 African American type 2 diabetics","NR","18p11.23",18,7755771,"PTPRM","- ",null,null,5797,null,null,"rs7243299-?","rs7243299",0,7243299,"intron",0,0.1,8e-06,5.09691001300805,null,1.63,"[1.31-2.03] ","Affymetrix [832,357]","N"]
["V1 (down-regulated)","05/27/2011",21546767,"Murea M","05/05/2011","Am J Nephrol","http://www.ncbi.nlm.nih.gov/pubmed/21546767","Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.","Dialysis-related mortality","610 African American type 2 diabetics","NR","7p15.3",7,22514053,"IL6, RAPGEF5","- ",null,null,256227,null,null,"rs17364464-?","rs17364464",0,17364464,"intron",0,0.08,4e-06,5.39794000867203,null,1.76,"[1.38-2.25] ","Affymetrix [832,357]","N"]
["V1 (down-regulated)","05/27/2011",21546767,"Murea M","05/05/2011","Am J Nephrol","http://www.ncbi.nlm.nih.gov/pubmed/21546767","Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.","Dialysis-related mortality","610 African American type 2 diabetics","NR","18p11.23",18,8209269,"PTPRM","- ",null,null,5797,null,null,"rs8098064-?","rs8098064",0,8098064,"intron",0,0.26,4e-06,5.39794000867203,null,1.42,"[1.22-1.65] ","Affymetrix [832,357]","N"]
["V1 (down-regulated)","05/28/2011",21552555,"Wang K","04/28/2011","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/21552555","A genome-wide association study on obesity and obesity-related traits.","Obesity","520 European ancestry cases, 540 European ancestry controls","1,196 non-Hispanic Caucasian individuals","13q21.32",13,66967622,"PCDH9","- ",null,null,5101,null,null,"rs17081231-?","rs17081231",0,17081231,"intron",0,"NR",7e-07,6.15490195998574,"(weight)","NR","NR","Illumina [~550,000]","N"]
["V1 (down-regulated)","05/11/2011",21483023,"Wu X","04/11/2011","J Natl Cancer Inst","http://www.ncbi.nlm.nih.gov/pubmed/21483023","Genome-wide association study of survival in non-small cell lung cancer patients receiving platinum-based chemotherapy.","Response to platinum-based chemotherapy in non-small-cell lung cancer","327 European ancestry individuals","587 European ancestry individuals","12q23.3",12,108699032,"CMKLR1","- ",null,null,1240,null,null,"rs1878022-?","rs1878022",0,1878022,"intron",0,"NR",5e-07,6.30102999566398,null,1.33,"[1.19-1.48] ","Illumina [307,260]","N"]
["V1 (down-regulated)","04/11/2011",21378990,"Schunkert H","03/06/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21378990","Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.","Coronary heart disease","22,233 European ancestry cases, 64,762 European ancestry controls","28,834 cases, 27,674 controls, 2,115 individuals.","17p13.3",17,2126504,"SMG6, SRR","- ",null,null,23293,null,null,"rs216172-C","rs216172",0,216172,"intron",0,0.37,1e-09,8.99999999999999,null,1.07,"[1.05-1.09] ","Affymetrix & Illumina {~2.3 million] (imputed)","N"]
["V1 (down-regulated)","04/07/2011",21408207,"Chung SA","03/03/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21408207","Differential genetic associations for systemic l (up-regulated)us erythematosus based on anti-dsDNA autoantibody production.","Systemic l (up-regulated)us erythematosus","811 anti-dsDNA positive European ancestry cases, 906 anti-dsDNA negative European ancestry cases, 4,813 European ancestry controls","NR","6p21.33",6,32050758,"TNXB","- ",null,null,7148,null,null,"rs1150754-A","rs1150754",0,1150754,"intron",0,0.13,6e-29,28.2218487496163,"(anti-dsDNA +)",2.21,"[1.93-2.53] ","Illumina [421,318] (imputed)","N"]
["V1 (down-regulated)","04/06/2011",21383967,"Zhernakova A","02/24/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21383967","Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.","Celiac disease and Rheumatoid arthritis","4,533 European ancestry celiac disease cases, 5,539 European ancestry rheumatoid arthritis cases, 27,981 European ancestry controls","2,169 celiac disease cases, 2,845 rheumatoid arthritis cases, 7,199 controls","2p23.1",2,30445026,"LBH",null,51646,81606,null,61.63,9.37,"rs7579944-?","rs7579944",0,7579944,null,1,"NR",1e-08,8,null,"NR","NR","Illumina [472,854]","N"]
["V1 (down-regulated)","04/06/2011",21383967,"Zhernakova A","02/24/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21383967","Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.","Celiac disease and Rheumatoid arthritis","4,533 European ancestry celiac disease cases, 5,539 European ancestry rheumatoid arthritis cases, 27,981 European ancestry controls","2,169 celiac disease cases, 2,845 rheumatoid arthritis cases, 7,199 controls","5q11.2",5,55560027,"ANKRD55",null,79722,345645,null,30.84,10.88,"rs1020388-?","rs1020388",0,1020388,null,1,"NR",3e-07,6.52287874528033,null,"NR","NR","Illumina [472,854]","N"]
["V1 (down-regulated)","04/07/2011",21347282,"Lettre G","02/10/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21347282","Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.","Coronary heart disease","8,090 African American individuals","8,849 African American or African-Caribbean individuals","16q22.1",16,67225501,"LCAT","- ",null,null,"1874;283849",null,null,"rs3729639-T","rs3729639",0,3729639,"nearGene-5;nearGene-5",0,0.44,2e-11,10.698970004336,"(HDL-C)",0.09,"[0.06-0.12] SD increase","Affymetrix [~2.74 million] (imputed)","N"]
["V1 (down-regulated)","03/02/2011",21244703,"Wang JH","01/18/2011","Genome Med","http://www.ncbi.nlm.nih.gov/pubmed/21244703","Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data.","Multiple sclerosis","2,124 cases, 6,720 controls","1,618 cases, 1,988 controls","11q12.2",11,60793651,"CD6",null,100189469,921,null,30.07,76.28,"rs4939490-?","rs4939490",0,4939490,null,1,"NR",1e-09,8.99999999999999,null,1.3,"[1.19-1.42] ","Affymetrix & Illumina [~2.56 million] (imputed)","N"]
["V1 (down-regulated)","01/12/2011",21116278,"Furney SJ","11/30/2010","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/21116278","Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.","MRI atrophy measures"," (up-regulated) to 434 Caucasian MCI cases, 236 Caucasian AD cases, 284 Caucasian controls","NR","13q12.3",13,31113379,"HMGB1",null,3146,100271871,null,73.3,0.06,"rs11618202-?","rs11618202",0,11618202,null,1,"NR",7e-06,5.15490195998574,"(total hippocampal volume)",0,"[NR] unit decrease (main effect)","Illumina [488,911]","N"]
["V1 (down-regulated)","12/16/2010",21060863,"Ikram MK","10/28/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21060863","Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.","Retinal vascular caliber","15,358 Caucasian individuals","6,673 individuals","12q24.12",12,111910219,"ATXN2,PTPN11,SH2B3","- ",null,null,6311,null,null,"rs10774625-A","rs10774625",0,10774625,"intron",0,0.48,2e-13,12.698970004336,null,1.5,"[1.11-1.89] um increase","Affymetrix & Illumina [2.2 million] (imputed)","N"]
["V1 (down-regulated)","12/03/2010",20966902,"Croteau-Chonka DC","10/21/2010","Obesity (Silver Spring)","http://www.ncbi.nlm.nih.gov/pubmed/20966902","Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.","Height","1,792 Filipino women","NR","2q33.2",2,204165171,"CYP20A1","- ",null,null,57404,null,null,"rs11888559-T","rs11888559",0,11888559,"UTR-3",0,0.15,2e-06,5.69897000433601,null,1.05,"[0.62-1.48] cm increase","Affymetrix [2,073,674](imputed)","N"]
["V1 (down-regulated)","11/17/2010",20935629,"Heid IM","10/10/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20935629","Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.","Waist-hip ratio"," (up-regulated) to 77,167 European descent individuals"," (up-regulated) to 113,636 European descent individuals","10p11.22",10,31990623,"ZEB1",null,2751,94134,null,83.49,103.7,"rs7081678-A","rs7081678",0,7081678,null,1,0.09,6e-06,5.22184874961635,null,0.03,"[NR] unit increase","Affymetrix, Illumina & Perlegen [ (up-regulated) to 2,850,269](imputed)","N"]
["V1 (down-regulated)","11/15/2010",20932654,"Kerns SL","10/05/2010","Int J Radiat Oncol Biol Phys","http://www.ncbi.nlm.nih.gov/pubmed/20932654","Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.","Erectile dysfunction and prostate cancer treatment","27 African American cases, 52 African American controls","NR","12q23.3",12,108767333,"CMKLR1",null,1240,11153,null,34.24,141.72,"rs10861905-?","rs10861905",0,10861905,null,1,0.01,8e-07,6.09691001300805,null,33.95,"[NR] ","Affymetrix [512,497]","N"]
["V1 (down-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","4q35.1",4,184215675,"WWC2","- ",null,null,80014,null,null,"rs955748-A","rs955748",0,955748,"intron",0,0.24,4e-08,7.39794000867203,null,0.02,"[NR] unit decrease","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V1 (down-regulated)","10/17/2010",20864672,"Waterworth DM","09/23/2010","Arterioscler Thromb Vasc Biol","http://www.ncbi.nlm.nih.gov/pubmed/20864672","Genetic variants influencing circulating lipid levels and risk of coronary artery disease.","HDL cholesterol"," (up-regulated) to 17,243 white European descent individuals"," (up-regulated) to 37,774 white European descent individuals,  (up-regulated) to 9,665 Indian Asian individuals","16q22.1",16,67708897,"GFOD2,LCAT","- ",null,null,81577,null,null,"rs12449157-G","rs12449157",0,12449157,"ncRNA",0,0.17,2e-07,6.69897000433601,null,0.02,"[0.01-0.03] unit increase","Affymetrix, Illumina & Perlegen [2,155,369] (imputed)","N"]
["V1 (down-regulated)","10/17/2010",20864672,"Waterworth DM","09/23/2010","Arterioscler Thromb Vasc Biol","http://www.ncbi.nlm.nih.gov/pubmed/20864672","Genetic variants influencing circulating lipid levels and risk of coronary artery disease.","Triglycerides"," (up-regulated) to 17,243 white European descent individuals"," (up-regulated) to 37,774 white European descent individuals,  (up-regulated) to 9,665 Indian Asian individuals","4q22.1",4,88030261,"AFF1","- ",null,null,4299,null,null,"rs442177-A","rs442177",0,442177,"intron",0,0.5,3e-10,9.52287874528033,null,0.02,"[0.01-0.03] unit increase","Affymetrix, Illumina & Perlegen [2,155,369] (imputed)","N"]
["V1 (down-regulated)","10/05/2010",20835239,"Solouki AM","09/12/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20835239","A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14.","Refractive error","5,328 European descent individuals","10,280 European descent individuals","15q14",15,35006073,"GJD2,ACTC1,GOLGA8B",null,440270,57369,null,130.3,38.57,"rs634990-C","rs634990",0,634990,null,1,0.47,2e-14,13.698970004336,null,0.23,"[0.228-0.232] diopter increase","Illumina [~2.5 million] (imputed)","N"]
["V1 (down-regulated)","09/23/2010",20719862,"Vitart V","08/18/2010","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/20719862","New loci associated with central cornea thickness include COL5A1, AKAP13 and AVGR8.","Central corneal thickness","1,445 European individuals","5,882 European individuals","15q25.3",15,85825567,"PDE8A,AKAP13",null,100216542,100151676,null,29.08,107.49,"rs6496932-C","rs6496932",0,6496932,null,1,0.22,1e-08,8,null,0.13,"[0.09-0.18] unit increase","Illumina [~2 million] (imputed)","N"]
["V1 (down-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","HDL cholesterol","99,900 European descent individuals",null,"16q22.1",16,67928042,"LCAT","- ",null,null,5681,null,null,"rs16942887-A","rs16942887",0,16942887,"intron",0,0.12,8e-33,32.096910013008,null,1.27,"[1.05-1.49] mg/dL increase","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V1 (down-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","Triglycerides"," (up-regulated) to 96,598 European descent individuals",null,"4q22.1",4,88030261,"AFF1,KLHL8","- ",null,null,4299,null,null,"rs442177-G","rs442177",0,442177,"intron",0,0.41,9e-12,11.0457574905606,null,2.25,"[1.51-2.99] mg/dL decrease","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V1 (down-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","Triglycerides"," (up-regulated) to 96,598 European descent individuals",null,"5q11.2",5,55861786,"ANKRD55,MAP3K1",null,441073,4214,null,60.85,249.11,"rs9686661-T","rs9686661",0,9686661,null,1,0.2,1e-10,10,null,2.57,"[1.61-3.53] mg/dL increase","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V1 (down-regulated)","07/13/2010",20585324,"Dick DM","06/27/2010","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/20585324","Genome-wide association study of conduct disorder symptomatology.","Conduct disorder (symptom count)","872 cases, 3,091 controls","NR","12q24.11",12,109025427,"SELPLG","- ",null,null,6404,null,null,"rs8179116-?","rs8179116",0,8179116,"intron",0,0.021,3e-06,5.52287874528033,null,0.23,"[NR] unit increase","Illumina [948,658]","N"]
["V1 (down-regulated)","07/16/2010",20585627,"Eriksson N","06/24/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20585627","Web-based, participant-driven studies yield novel genetic associations for common traits.","Eye color","9,126 European ancestry individuals","NR","15q13.1",15,28365618,"OCA2","- ",null,null,8924,null,null,"rs12913832-A","rs12913832",0,12913832,"intron",0,0.23,3e-52,51.5228787452803,"(green eyes)",8.43,"[NR] ","Illumina [535,076]","N"]
["V1 (down-regulated)","07/16/2010",20585627,"Eriksson N","06/24/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20585627","Web-based, participant-driven studies yield novel genetic associations for common traits.","Eye color","9,126 European ancestry individuals","NR","15q13.1",15,28365618,"OCA2","- ",null,null,8924,null,null,"rs12913832-A","rs12913832",0,12913832,"intron",0,0.23,1e-300,299.999999999999,"(eye color)",2.49,"[NR] unit increase","Illumina [535,076]","N"]
["V1 (down-regulated)","07/16/2010",20585627,"Eriksson N","06/24/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20585627","Web-based, participant-driven studies yield novel genetic associations for common traits.","Hair color","9,126 European ancestry individuals","NR","15q13.1",15,28365618,"OCA2","- ",null,null,8924,null,null,"rs12913832-A","rs12913832",0,12913832,"intron",0,0.23,9e-88,87.0457574905606,"(hair color)",0.97,"[NR] unit increase","Illumina [535,076]","N"]
["V1 (down-regulated)","06/22/2010",20526338,"Johnson AD","06/06/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20526338","Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.","Platelet aggregation"," (up-regulated) to 3,991 European ancestry individuals"," (up-regulated) to 840 African American individuals","10q24.33",10,105257786,"NEURL","- ",null,null,9148,null,null,"rs7071247-T","rs7071247",0,7071247,"intron",0,0.119,2e-07,6.69897000433601,"(epinephrine)","NR","NR","Affymetrix & Illumina [~2.33 million] (imputed)","N"]
["V1 (down-regulated)","06/08/2010",20453840,"Sanna S","05/09/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20453840","Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis.","Multiple sclerosis","882 Sardinian cases, 872 Sardinian controls","1,775 Sardinian cases, 2,005 Sardinian controls","3q13.11",3,105586714,"CBLB","- ",null,null,868,null,null,"rs9657904-T","rs9657904",0,9657904,"intron",0,0.826,2e-10,9.69897000433601,null,1.4,"[1.27-1.57] ","Affymetrix [6,607,266] (imputed)","N"]
["V1 (down-regulated)","06/13/2010",20453842,"Stahl EA","05/09/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20453842","Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.","Rheumatoid arthritis","5,539 European ancestry cases, 20,169 European ancestry controls","6,768 European ancestry cases, 8,806 European ancestry controls","5q11.2",5,55438580,"ANKRD55,IL6ST","- ",null,null,79722,null,null,"rs6859219-C","rs6859219",0,6859219,"intron",0,0.79,1e-11,11,null,1.28,"[NR] ","Affymetrix & Illumina [~2,716,259] (imputed)","N"]
["V1 (down-regulated)","05/23/2010",20400778,"Morrison AC","04/17/2010","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/20400778","Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium.","Mortality among heart failure patients","2,526 European ancestry individuals, 466 African ancestry individuals","NR","10q22.3",10,79444753,"KCNMA1",null,3778,100129156,null,47.18,53.23,"rs4979906-G","rs4979906",0,4979906,null,1,0.186,7e-06,5.15490195998574,"(EA)",1.23,"[0.98-1.55] ","Affymetrix [~2.4 million] (imputed)","N"]
["V1 (down-regulated)","05/18/2010",20395239,"Macgregor S","04/15/2010","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/20395239","Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.","Optic disc size (disc)","1,368 Australian twins, 848 UK individuals","NR","14q32.2",14,101251989,"MEG3",null,8788,100616495,null,50.52,28.84,"rs1884537-C","rs1884537",0,1884537,null,1,"NR",2e-06,5.69897000433601,null,0.13,"[0.05-0.21] unit increase","Illumina [~2.74 million] (imputed)","N"]
["V1 (down-regulated)","05/05/2010",20383145,"Chambers JC","04/11/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20383145","Genetic loci influencing kidney function and chronic kidney disease.","Creatinine levels","23,812 European descent individuals","16,626 European individuals","2p13.1",2,73900900,"NAT8,NAT8B,ALMS1,DUSP11,TPRKB","- ",null,null,200420,null,null,"rs10206899-G","rs10206899",0,10206899,"intron",0,0.22,1e-15,15,null,1,"[0.7-1.2] % decrease","Affymetrix, Illumina and Perlegen [~2.6 Million] (imputed)","N"]
["V1 (down-regulated)","05/05/2010",20383146,"Kottgen A","04/11/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20383146","New loci associated with kidney function and chronic kidney disease.","Chronic kidney disease"," (up-regulated) to 67,093 European ancestry individuals"," (up-regulated) to 22,982 European ancestry individuals","12q24.12",12,112007756,"ATXN2","- ",null,null,6311,null,null,"rs653178-T","rs653178",0,653178,"intron",0,0.5,4e-11,10.397940008672,"(eGFRcys)",0.01,"[0.009-0.017] ml/min/1.73 m2 increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (down-regulated)","05/05/2010",20383146,"Kottgen A","04/11/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20383146","New loci associated with kidney function and chronic kidney disease.","Chronic kidney disease"," (up-regulated) to 67,093 European ancestry individuals"," (up-regulated) to 22,982 European ancestry individuals","2p13.1",2,73868328,"NAT8,NAT8B,ALMS1","- ",null,null,9027,null,null,"rs13538-G","rs13538",0,13538,"missense",0,0.23,5e-14,13.3010299956639,"(eGFRcrea)",0.01,"[0.005-0.013] ml/min/1.73 m2 increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (down-regulated)","04/14/2010",20339536,"Barber MJ","03/22/2010","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/20339536","Genome-wide association of lipid-lowering response to statins in combined study populations.","Response to statin therapy","3,928 Caucasian individuals","NR","9q21.33",9,86922036,"SLC28A3, RMI1, LOC729388","- ",null,null,64078,null,null,"rs10123041-T","rs10123041",0,10123041,"intron",0,0.16,6e-06,5.22184874961635,"(HDL, sum)","NR","NR","Illumina [~2.5 million](imputed)","N"]
["V1 (down-regulated)","04/02/2010",20228799,"McGovern DP","03/14/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20228799","Genome-wide association identifies multiple ulcerative colitis susceptibility loci.","Ulcerative colitis","2,693 European descent cases, 6,791 European descent controls","2,009 European descent cases, 1,580 European descent controls","16p13.13",16,10975311,"CIITA","- ",null,null,4261,null,null,"rs4781011-T","rs4781011",0,4781011,"intron",0,"NR",3e-06,5.52287874528033,null,1.12,"[NR] ","Affymetrix [266,047]","N"]
["V1 (down-regulated)","03/29/2010",20190752,"Dubois PC","02/28/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20190752","Multiple common variants for celiac disease influencing immune gene expression.","Celiac disease","4,533 European descent cases, 10,750 European descent controls","4,918 European descent cases, 5,684 European descent controls","16p13.13",16,11403893,"CIITA, SOCS1, CLEC16A",null,100313773,116028,null,3.51,35.42,"rs12928822-?","rs12928822",0,12928822,null,1,0.84,3e-08,7.52287874528033,null,1.16,"[1.10-1.22] ","Illumina [292,387]","N"]
["V1 (down-regulated)","03/17/2010",20174558,"Tsai FJ","02/19/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20174558?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese.","Type 2 diabetes","995 Han Chinese cases, 894 Han Chinese controls","1,803 Han Chinese cases, 1,473 Han Chinese controls","17p13.3",17,2216258,"SRR","- ",null,null,63826,null,null,"rs391300-G","rs391300",0,391300,"intron",0,0.62,3e-09,8.52287874528033,null,1.28,"[1.18-1.39] ","Illumina [516,737]","N"]
["V1 (down-regulated)","01/19/2010",20041166,"Fellay J","12/24/2009","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20041166?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Common genetic variation and the control of HIV-1 in humans.","HIV-1 control","2,362 Caucasian cases","NR","6p21.33",6,32026808,"TNXB","- ",null,null,7148,null,null,"rs12198173-?","rs12198173",0,12198173,"intron",0,"NR",3e-06,5.52287874528033,"(progression)","NR","NR","Illumina [NR]","N"]
["V1 (down-regulated)","12/28/2009",19966805,"Wallace C","12/06/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19966805?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=7","The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes.","Type 1 diabetes","7,514 European ancestry cases, 9,045 European ancestry controls","4,840 European ancestry cases, 2,670 European ancestry controls, 4,152 European ancestry familial triads","14q32.2",14,101306045,"DLK1, MEG3, RTL1, DIO3","- ",null,null,55384,null,null,"rs941576-A","rs941576",0,941576,"intron",0,0.57,1e-10,10,null,1.11,"[1.06-1.16] ","Affymetrix & Illumina [~2.6 million](imputed)","N"]
["V1 (down-regulated)","12/10/2009",19915574,"Imielinski M","11/15/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19915574?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Common variants at five new loci associated with early-onset inflammatory bowel disease.","Inflammatory bowel disease (early onset)","2,413 European ancestry cases, 6,158 European ancestry controls","1,013 European ancestry cases, 5,805 European ancestry controls","16p11.2",16,28837515,"IL27, CCDC101, CLN3, EIF3C, N (up-regulated)R1, SULT1A1, SULT1A2","- ",null,null,11273,null,null,"rs8049439-G","rs8049439",0,8049439,null,0,0.37,2e-09,8.69897000433601,null,1.14,"[1.00-1.30] ","Illumina [~500,000]","N"]
["V1 (down-regulated)","11/03/2009",19862010,"Ganesh SK","10/11/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19862010?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.","Hematocrit","24,167 European ancestry individuals","9,456 European ancestry individuals","12q24.12",12,112072424,"SH2B3, ATXN2",null,6311,8315,null,34.94,7.53,"rs11065987-G","rs11065987",0,11065987,null,1,"NR",1e-12,12,null,0.17,"[0.12-0.22] % decrease","Affymetrix & Illumina [~2.5 million](imputed)","N"]
["V1 (down-regulated)","10/05/2009",19772629,"Latourelle JC","09/22/2009","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/19772629?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genomewide association study for onset age in Parkinson disease.","Parkinson's disease (age of onset)","857 white familial cases, 440 white idiopathic cases","747 Italian idiopathic cases","15q12",15,27997247,"OCA2",null,2567,100271207,null,218.87,143.56,"rs17565841-A","rs17565841",0,17565841,null,1,"NR",3e-06,5.52287874528033,null,2.84,"[NR] years younger","Illumina and Perlegen [1,861,750] (imputed)","N"]
["V1 (down-regulated)","12/29/2009",19767753,"Eeles RA","09/20/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19767753?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=6","Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.","Prostate cancer","1,854 European ancestry cases, 1,894 European ancestry controls","19,879 cases, 18,761 controls (European, Chinese, Japanese, African American, Latino, and Hawaiian ancestry)","2p15",2,63301164,"EHBP1",null,5013,100270969,null,16.2,34.07,"rs6545977-A","rs6545977",0,6545977,null,1,"NR",5e-07,6.30102999566398,null,"NR","NR","Illumina [541,129]","N"]
["V1 (down-regulated)","08/07/2009",19584346,"Vasan RS","07/08/2009","JAMA","http://www.ncbi.nlm.nih.gov/pubmed/19584346?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.","Aortic root size","12,612 European ancestry individuals","4,094 European ancestry individuals","17p13.3",17,2143460,"SMG6, SRR, TSR1, SGSM2","- ",null,null,23293,null,null,"rs10852932-T","rs10852932",0,10852932,"intron",0,0.36,2e-11,10.698970004336,null,0.03,"[0.02-0.04] cm increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V1 (down-regulated)","06/29/2009",19525953,"De Jager PL","06/14/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19525953?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.","Multiple sclerosis","2,624 cases, 7,220 controls","2,215 cases, 2,116 controls","11q12.2",11,60760612,"CD6","- ",null,null,923,null,null,"rs17824933-G","rs17824933",0,17824933,"intron",0,0.25,4e-09,8.39794000867203,null,1.18,"[1.07-1.30] ","Affymetrix & Illumina [~2.56 million] (imputed)","N"]
["V1 (down-regulated)","06/29/2009",19525953,"De Jager PL","06/14/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19525953?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.","Multiple sclerosis","2,624 cases, 7,220 controls","2,215 cases, 2,116 controls","12q24.31",12,123656725,"MPHOSPH9","- ",null,null,10198,null,null,"rs1790100-G","rs1790100",0,1790100,"intron",0,0.24,7e-07,6.15490195998574,null,1.11,"[1.00-1.22] ","Affymetrix & Illumina [~2.56 million] (imputed)","N"]
["V1 (down-regulated)","05/19/2009",19430483,"Newton-Cheh C","05/10/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19430483?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association study identifies eight loci associated with blood pressure.","Diastolic blood pressure","34,433 individuals"," (up-regulated) to 100,347 white individuals,  (up-regulated) to 12,889 Indian Asian individuals","12q24.12",12,112007756,"ATXN2, SH2B3","- ",null,null,6311,null,null,"rs653178-T","rs653178",0,653178,"intron",0,0.53,3e-18,17.5228787452803,null,0.46,"[0.36-0.56] mm Hg decrease","Affymetrix & Illumina [2,497,993] (imputed)","N"]
["V1 (down-regulated)","04/01/2009",19247474,"Caporaso N","02/27/2009","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/19247474?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide and candidate gene association study of cigarette smoking behaviors.","Smoking behavior","4,611 individuals (2,617 smokers)","NR","17p13.2",17,3786907,"CAMKK1","- ",null,null,84254,null,null,"rs758642-?","rs758642",0,758642,"intron",0,0.34,7e-06,5.15490195998574,"(CPD)",0.08,"[NR] more cigarettes per day","Illumina [~518,000]","N"]
["V1 (down-regulated)","01/21/2009",19122664,"Silverberg MS","01/04/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19122664?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.","Ulcerative colitis","1,022 cases, 2,503 controls","1,387 cases, 1,115 controls","12q15",12,68504592,"IFNG, IL26, IL22",null,100271520,3458,null,109.26,43.96,"rs1558744-A","rs1558744",0,1558744,null,1,0.38,3e-12,11.5228787452803,null,1.35,null,"Illumina [280,748]","N"]
["V1 (down-regulated)","01/16/2009",19115949,"Limou S","01/01/2009","J Infect Dis","http://www.ncbi.nlm.nih.gov/pubmed/19115949?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).","AIDS progression","275 HIV positive patients, 1,438 controls","626 patients","6p21.33",6,31431780,"HCP5, MICB, MCCD1, BAT1, LTB, TNF","- ",null,null,10866,null,null,"rs2395029-G","rs2395029",0,2395029,"ncRNA",0,0.03,3e-19,18.5228787452803,null,3.47,"[2.39-5.04] ","Illumina [291,119]","N"]
["V1 (down-regulated)","01/12/2009",19060906,"Kathiresan S","12/07/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19060906?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Common variants at 30 loci contribute to polygenic dyslipidemia.","HDL cholesterol","19,840 individuals"," (up-regulated) to 20,623 individuals","16q22.1",16,67902070,"LCAT","- ",null,null,10204,null,null,"rs2271293-A","rs2271293",0,2271293,"intron",0,0.11,9e-13,12.0457574905606,null,0.07,"[0.01-0.13] s.d. increase","Affymetrix and Illumina [~2,600,000] (imputed)","N"]
["V1 (down-regulated)","01/12/2009",19060910,"Sabatti C","12/07/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19060910?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.","HDL cholesterol","4,763 individuals","NR","16q22.1",16,68013471,"LCAT","- ",null,null,64180,null,null,"rs255049-G","rs255049",0,255049,"intron",0,0.22,3e-08,7.52287874528033,null,0.05,"[0.03-0.07] mmol/l increase","Illumina [329,091]","N"]
["V1 (down-regulated)","01/16/2009",19010793,"Baranzini SE","11/14/2008","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19010793?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.","Multiple sclerosis","978 cases,883 controls","NR","20p13",20,1205886,"C20orf46","- ",null,null,642636,null,null,"rs397020-?","rs397020",0,397020,"nearGene-5",0,0.52,8e-07,6.09691001300805,null,1.41,"[NR] ","Illumina[551,642]","N"]
["V1 (down-regulated)","11/25/2008",18483556,"Han J","05/16/2008","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/18483556?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.","Black vs. blond hair color","2,287 women"," (up-regulated) to 8,465 individuals","15q13.1",15,28335820,"OCA2","- ",null,null,4948,null,null,"rs11855019-G","rs11855019",1,4778138,"intron",0,"NR",2e-24,23.698970004336,null,0.28,"[0.22-0.34] decrease in hair color score","Illumina[528,173]","N"]
["V1 (down-regulated)","11/25/2008",18483556,"Han J","05/16/2008","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/18483556?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.","Black vs. red hair color","2,287 women"," (up-regulated) to 8,465 individuals","15q13.1",15,28335820,"OCA2","- ",null,null,4948,null,null,"rs11855019-G","rs11855019",1,4778138,"intron",0,"NR",6e-20,19.2218487496163,null,0.29,"[0.23-0.35] decrease in hair color score","Illumina[528,173]","N"]
["V1 (down-regulated)","11/25/2008",18391951,"Gudbjartsson DF","04/06/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18391951?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Many sequence variants affecting diversity of adult human height.","Height","30,968 individuals","8,541 individuals","6p21.31",6,34195011,"HMGA1, LBH",null,157317,3159,null,6.3,9.57,"rs1776897-C","rs1776897",0,1776897,null,1,0.07,1e-08,8,null,8.8,"[5.66-11.94] % s.d. taller","Illumina and Affymetrix[ (up-regulated) to 304,226]","N"]
["V1 (down-regulated)","11/25/2008",18391951,"Gudbjartsson DF","04/06/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18391951?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Many sequence variants affecting diversity of adult human height.","Height","30,968 individuals","8,541 individuals","16q24.1",16,84987679,"ZDHHC7, CRISPLD2, USP10",null,83716,55625,null,44.56,20.39,"rs2326458-C","rs2326458",0,2326458,null,1,0.26,8e-07,6.09691001300805,null,5.1,"[3.14-7.06] % s.d. taller","Illumina and Affymetrix[ (up-regulated) to 304,226]","N"]
["V1 (down-regulated)","11/25/2008",18311140,"Hunt KA","03/02/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18311140?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Newly identified genetic risk variants for celiac disease related to the immune response.","Celiac disease","767 cases,1,422 controls","1,643 cases,3,406 controls","12q24.12",12,112007756,"SH2B3, ATXN2","- ",null,null,6311,null,null,"rs653178-G","rs653178",0,653178,"intron",0,0.48,8e-08,7.09691001300805,null,1.21,"[1.13-1.30] ","Illumina[310,605]","N"]
["V1 (down-regulated)","11/25/2008",18264098,"Gudmundsson J","02/10/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18264098?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.","Prostate cancer","1,854 cases,21,372 controls","8,239 cases,7,590 controls","2p15",2,63131731,"EHBP1","- ",null,null,23301,null,null,"rs721048-A","rs721048",0,721048,"intron",0,0.19,8e-09,8.09691001300805,null,1.15,"[1.10-1.21] ","Illumina[310,520]","N"]
["V1 (down-regulated)","11/25/2008",18193043,"Willer CJ","01/13/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18193043?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Newly identified loci that influence lipid concentrations and risk of coronary artery disease.","HDL cholesterol","8,656 individuals","11,399 individuals","16q22.1",16,68024995,"LCAT","- ",null,null,64174,null,null,"rs255052-A","rs255052",0,255052,null,0,0.17,1e-07,7,null,0.74,"[NR] mg/dl higher","Illumina and Affymetrix[~2,261,000] (imputed)","N"]
["V1 (down-regulated)","11/25/2008",17952075,"Sulem P","10/21/2007","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/17952075?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genetic determinants of hair, eye and skin pigmentation in Europeans.","Blond vs. brown hair color","2,986 individuals","3,932 individuals","15q13.1",15,28530182,"OCA2","- ",null,null,8924,null,null,"rs1667394-A","rs1667394",0,1667394,"intron",0,0.88,6e-35,34.2218487496163,null,4.94,"[3.16-7.71] ","Illumina[317,511]","N"]
["V1 (down-regulated)","02/16/2009",17952075,"Sulem P","10/21/2007","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/17952075?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum+E2","Genetic determinants of hair, eye and skin pigmentation in Europeans.","Blue vs. brown eyes","2,986 individuals","3,932 individuals","15q13.1",15,28530182,"OCA2","- ",null,null,8924,null,null,"rs1667394-A","rs1667394",0,1667394,"intron",0,0.88,1e-241,241,null,29.43,"[21.47-40.35] ","Illumina[317,511]","N"]
["V1 (down-regulated)","11/25/2008",17952075,"Sulem P","10/21/2007","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/17952075?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genetic determinants of hair, eye and skin pigmentation in Europeans.","Blue vs. green eyes","2,986 individuals","3,932 individuals","15q13.1",15,28530182,"OCA2","- ",null,null,8924,null,null,"rs1667394-A","rs1667394",0,1667394,"intron",0,0.98,2e-53,52.698970004336,null,6.74,"[4.61-9.83] ","Illumina[317,511]","N"]
["V1 (down-regulated)","11/25/2008",17903292,"Hwang SJ","09/19/2007","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/17903292?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study.","Thyroid stimulating hormone","810-1,010 individualsdepending on measure(Framingham)","NR","7p15.3",7,22109459,"RAPGEF5",null,55536,9771,null,123.92,48.45,"rs10499559-?","rs10499559",0,10499559,null,1,"NR",8e-06,5.09691001300805,null,"NR","NR","Affymetrix[70,897]","N"]
["V1 (down-regulated)","11/25/2008",17903305,"Murabito JM","09/19/2007","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/17903305?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study.","Breast cancer","1,345 individuals(Framingham)","NR","17q21.33",17,48274291,"COL1A1","- ",null,null,1277,null,null,"rs2075555-?","rs2075555",0,2075555,"intron",0,"NR",8e-08,7.09691001300805,null,"NR","NR","Affymetrix[70,897]","N"]
["V2 (up-regulated)","05/26/2013",23455491,"Zuo L","02/27/2013","Drug Alcohol Depend","http://www.ncbi.nlm.nih.gov/pubmed/23455491","NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent.","Alcohol dependence","1,409 European ancestry cases, 1,518 European ancestry controls","6,438 European ancestry individuals from 1,645 affected families","1p35.2",1,31883925,"NKAIN1, SNRNP40, ZCCHC17, FABP3, SERINC2","- ",null,null,347735,null,null,"rs4478858-G","rs4478858",0,4478858,"intron",0,"NR",3e-08,7.52287874528033,null,1.26,null,"Illumina [805,814]","N"]
["V2 (up-regulated)","06/28/2013",23446634,"Chen Z","02/26/2013","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23446634","Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.","Red blood cell traits"," (up-regulated) to 16,485 African American individuals","9,692 African American individuals, 21,020 European ancestry individuals, 14,088 Japanese ancestry individuals","16p13.3",16,310380,"ITFG3, LUCL7, NPRL3, POLR3K, RPL2B, MPG, NME4, DECR, RHOT2, LMF1,WDR90","- ",null,null,83986,null,null,"rs13335629-A","rs13335629",0,13335629,"intron",0,0.134,4e-22,21.397940008672,"(MCV, AA)",0.65,"[0.52-0.78] fL decrease","Affymetrix & Illumina [NR]","N"]
["V2 (up-regulated)","05/24/2013",23406172,"Milton JN","02/14/2013","Br J Haematol","http://www.ncbi.nlm.nih.gov/pubmed/23406172","Genetic determinants of haemolysis in sickle cell anaemia.","Sickle cell anemia (haemolysis)","1,117 individuals","958 African, West African, Afro-Caribbean, NR individuals","2p16.1",2,60719970,"BCL11A","- ",null,null,53335,null,null,"rs766432-?","rs766432",0,766432,"intron",0,"NR",9e-07,6.04575749056067,null,0.22,"NR unit increase","Illumina [569,554]","N"]
["V2 (up-regulated)","05/11/2013",23400010,"Del-Aguila JL","02/12/2013","Pharmacogenomics J","http://www.ncbi.nlm.nih.gov/pubmed/23400010","Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.","Thiazide-induced adverse metabolic effects in hypertensive patients","425 European ancestry cases, 342 African American cases","NR","16q24.1",16,85906616,"COX4I1",null,401863,3394,null,56.44,26.16,"rs11648716-G","rs11648716",0,11648716,null,1,0.08,7e-06,5.15490195998574,"(EA-triglyceride response)",39.68,"[22.37-56.99] mg/dL decrease","Illumina and Affymetrics [>2 million] (Imputed)","N"]
["V2 (up-regulated)","05/11/2013",23400010,"Del-Aguila JL","02/12/2013","Pharmacogenomics J","http://www.ncbi.nlm.nih.gov/pubmed/23400010","Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.","Thiazide-induced adverse metabolic effects in hypertensive patients","425 European ancestry cases, 342 African American cases","NR","14q32.11",14,90396574,"c14ORF143","- ",null,null,90141,null,null,"rs7147996-A","rs7147996",0,7147996,"intron",0,0.12,6e-06,5.22184874961635,"(AA-triglyceride response)",28.09,"[15.96-40.22] mg/dL decrease","Illumina and Affymetrics [>2 million] (Imputed)","N"]
["V2 (up-regulated)","06/06/2013",23396134,"Verhoeven VJ","02/10/2013","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23396134","Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.","Refractive error","37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals",null,"10q23.33",10,94924324,"CYP26A1",null,1592,643863,null,86.68,119.4,"rs10882165-T","rs10882165",0,10882165,null,1,0.42,1e-11,11,null,0.11,"[0.076-0.138] unit decrease","Illumina & Affymetrix [2.5 million] (imputed)","N"]
["V2 (up-regulated)","03/28/2013",23291589,"Lu Y","01/06/2013","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23291589 ","Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.","Corneal structure","13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals","NR","17p12",17,14561016,"HS3ST3B1, PMP22",null,9953,388339,null,311.52,47.34,"rs12940030-T","rs12940030",0,12940030,null,1,0.71,7e-10,9.15490195998574,null,0.08,"[0.06-0.1] unit increase","Illumina & Affymetrix [~1 Million] (Imputed)","N"]
["V2 (up-regulated)","03/19/2013",23279374,"Athanasiadis G","01/02/2013","J Thromb Haemost","http://www.ncbi.nlm.nih.gov/pubmed/23279374 ","Genetic determinants of plasma &#x003b2;&#x02082;-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain.","&beta;2-Glycoprotein I (&beta;2-GPI) plasma levels","306 European ancestry individuals","NR","5p14.1",5,25692973,"CDH10, CDH9",null,1008,4479,null,1047.89,216.44,"rs193741-A","rs193741",0,193741,null,1,0.14,2e-06,5.69897000433601,null,0.64,"(unit decrease)","Illumina [283,437]","N"]
["V2 (up-regulated)","03/20/2013",23381943,"Williams FM","01/01/2013","Ann Neurol","http://www.ncbi.nlm.nih.gov/pubmed/23381943 ","Ischemic stroke is associated with the ABO locus: the EuroCLOT study.","End-stage coagulation","2,100 European ancestry individuals","NR","1p21.3",1,95052476,"F3",null,2152,100421182,null,45.06,86,"rs2022309-G","rs2022309",0,2022309,null,1,0.701,4e-08,7.39794000867203,"(D-dimer)",0.24,"[0.16-0.33] unit decrease","Illumina [NR] (imputed)","N"]
["V2 (up-regulated)","02/26/2013",23259602,"Wang X","12/21/2012","BMC Oral Health","http://www.ncbi.nlm.nih.gov/pubmed/23259602","Genome-wide association scan of dental caries in the permanent dentition.","Dental caries","1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals",null,"14q22.2",14,54876184,"CDKN3, CNIH, GMFB, CGRRF1, BMP4","- ",null,null,1033,null,null,"rs4251631-?","rs4251631",0,4251631,"intron",0,"NR",2e-06,5.69897000433601,null,"NR","NR","Illumina and Affymetrix [~ 1.4 Million] (imputed)","N"]
["V2 (up-regulated)","02/26/2013",23259602,"Wang X","12/21/2012","BMC Oral Health","http://www.ncbi.nlm.nih.gov/pubmed/23259602","Genome-wide association scan of dental caries in the permanent dentition.","Dental caries","1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals",null,"14q22.2",14,54876184,"CDKN3, CNIH, GMFB, CGRRF1, BMP4","- ",null,null,1033,null,null,"rs4251631-?","rs4251631",0,4251631,"intron",0,"NR",2e-07,6.69897000433601,"(Comparatively Younger)","NR","NR","Illumina and Affymetrix [~ 1.4 Million] (imputed)","N"]
["V2 (up-regulated)","03/15/2013",23263863,"Li J","12/20/2012","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263863","GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.","Hematology traits","7,943 African American children, 6,234 European ancestry children","NR","6p21.33",6,31940897,"ZBTB12, CFB, STK19 ","- ",null,null,"1797;8859",null,null,"rs389884-C ","rs389884",0,389884,"nearGene-5;intron",0,0.0953,2e-08,7.69897000433601,"(EA, WBC)",0.03,"[0.017-0.034] unit decrease","Illumina [544,917]","N"]
["V2 (up-regulated)","03/19/2013",23222517,"van der Harst P","12/05/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23222517","Seventy-five genetic loci influencing the human red blood cell.","Red blood cell traits","62,553 European ancestry individuals, 9,308 South Asian ancestry individuals","63,506 European ancestry individuals","22q13.33",22,50971266,"ODF3B, TYMP, NCAPH2, SCO2","- ",null,null,440836,null,null,"rs140522-C","rs140522",0,140522,"nearGene-5",0,0.67,5e-23,22.3010299956639,"(EA, MCV)",0.29,"[0.23-0.35] unit increase","Illumina, Affymetrix & Perlegen [2,711,806] imputed","N"]
["V2 (up-regulated)","03/19/2013",23222517,"van der Harst P","12/05/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23222517","Seventy-five genetic loci influencing the human red blood cell.","Red blood cell traits","62,553 European ancestry individuals, 9,308 South Asian ancestry individuals","63,506 European ancestry individuals","2p16.1",2,60620286,"BCL11A",null,100616473,53335,null,5.71,58.02,"rs243070-T","rs243070",0,243070,null,1,0.72,4e-13,12.397940008672,"(EA, MCV)",0.18,"[0.13-0.23] unit decrease","Illumina, Affymetrix & Perlegen [2,711,806] imputed","N"]
["V2 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","17q11.2",17,31393702,"ACCN1","- ",null,null,40,null,null,"rs17808461-A","rs17808461",0,17808461,"intron",0,0.117,4e-06,5.39794000867203,"(MCP1 )",0.02,"[NR]  pg/mL increase","Illumina [899,892]","N"]
["V2 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","11q23.3",11,115301871,"CADM1","- ",null,null,23705,null,null,"rs220836-G","rs220836",0,220836,"intron",0,0.16,6e-06,5.22184874961635,"(AST )",0.03,"[NR]  U/L increase","Illumina [899,892]","N"]
["V2 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","1p36.12",1,21654735,"ECE1","- ",null,null,1889,null,null,"rs213032-G","rs213032",0,213032,"intron",0,0.281,6e-06,5.22184874961635,"(Sleep duration )",0.03,"[NR]  min/d increase","Illumina [899,892]","N"]
["V2 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","17q12",17,32593974,"CCL13,CCL2,CCL11",null,6347,6354,null,9.75,3.27,"rs3091316-G","rs3091316",0,3091316,null,1,0.722,1e-26,26,null,1.12,"[1.087-1.158] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V2 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","22q12.2",22,30486826,"LIF,OSM,MTMR3","- ",null,null,150280,null,null,"rs2412970-G","rs2412970",0,2412970,"intron",0,0.457,3e-14,13.5228787452803,null,1.08,"[1.049-1.111] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V2 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","3p21.31",3,49721532,"MST1,PFKFB4,MST1R,UCN2,GPX1,IP6K2,BSN,IP6K1,USP4","- ",null,null,4485,null,null,"rs3197999-A","rs3197999",0,3197999,"missense",0,0.296,1e-47,47,null,1.18,"[1.144-1.216] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V2 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","4q13.3",4,74857708,"CXCL5,CXCL1,CXCL3,IL8,CXCL6,PF4,CXCL2,PF4V1",null,5473,6374,null,3.8,3.65,"rs2472649-G","rs2472649",0,2472649,null,1,0.824,3e-08,7.52287874528033,null,1.1,"[1.046-1.146] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V2 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","5q31.1",5,131770805,"IRF1,IL13,CSF2,SLC22A4,IL4,IL3,IL5,PDLIM4,SLC22A5,ACSL6","- ",null,null,441108,null,null,"rs2188962-T","rs2188962",0,2188962,"intron",0,0.425,1e-52,51.9999999999999,null,1.16,"[1.125-1.191] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V2 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","10p11.23",10,30728101,"MAP3K8","- ",null,null,1326,null,null,"rs1042058-C","rs1042058",0,1042058,"cds-synon",0,0.592,6e-11,10.2218487496163,null,1.08,"[1.044-1.106] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V2 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","12q13.11",12,48208368,"VDR","- ",null,null,51564,null,null,"rs11168249-C","rs11168249",0,11168249,"intron",0,0.467,8e-09,8.09691001300805,null,1.05,"[1.024-1.084] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V2 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","1p36.23",1,8021973,"TNFRSF9","- ",null,null,11315,null,null,"rs35675666-G","rs35675666",0,35675666,"intron",0,0.838,1e-15,15,null,1.11,"[1.07-1.156] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V2 (up-regulated)","12/11/2012",22960999,"Wu C","09/09/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22960999","Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions.","Esophageal cancer (squamous cell)","2,031 Han Chinese cases, 2,044 Han Chinese controls","8,092 Chinese ancestry cases, 8,620 Chinese ancestry controls","17q21.2",17,39897264,"HAP1",null,9001,3728,null,6.37,13.6,"rs6503659-A","rs6503659",0,6503659,null,1,0.13,3e-16,15.5228787452803,null,1.27,"[1.20-1.34] ","NR","N"]
["V2 (up-regulated)","01/15/2013",23225573,"Buck D","09/08/2012","Ann Neurol","http://www.ncbi.nlm.nih.gov/pubmed/23225573","Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis.","IgG levels","229 European ancestry multiple sclerosis cases","409 European ancestry multiple sclerosis cases","14q32.33",14,106232585,"IGHG3, IGHG1, IGHG2","- ",null,null,3502,null,null,"rs10136766-A","rs10136766",0,10136766,null,0,0.27,8e-16,15.096910013008,null,0.23,"[NR] unit increase","Illumina [526,014]","N"]
["V2 (up-regulated)","11/05/2012",22952603,"Hart AB","08/28/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/22952603","Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).","Response to amphetamines","1 American Indian ancestry individual, 18 African American/Afro-Caribbean ancestry individuals, 10 East Asian and South Asian ancestry individuals, 325 European ancestry individuals, 17 Latin American ancestry individuals, 6 other ancestry individuals, 4 individuals","NR","5p15.31",5,6635591,"SRD5A1","- ",null,null,6715,null,null,"rs472402-?","rs472402",0,472402,"intron",0,"NR",3e-07,6.52287874528033,"(SF2)","NR","NR","Affymetrix [5,476,100] (imputed)","N"]
["V2 (up-regulated)","11/21/2012",22916037,"Inouye M","08/16/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22916037","Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.","Metabolite levels","6,608 European ancestry individuals","NR","2p14",2,65208074,"SLC1A4",null,100133170,6509,null,20.32,7.51,"rs10211524-?","rs10211524",0,10211524,null,1,0.39,3e-10,9.52287874528033,null,"NR","NR","Illumina [~2 million] (imputed)","N"]
["V2 (up-regulated)","11/21/2012",22916037,"Inouye M","08/16/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22916037","Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.","Metabolite levels","6,608 European ancestry individuals","NR","4q22.1",4,89226422,"PPM1K, HERC6",null,152926,55008,null,20.44,73.47,"rs1440581-?","rs1440581",0,1440581,null,1,0.47,1e-10,10,null,"NR","NR","Illumina [~2 million] (imputed)","N"]
["V2 (up-regulated)","10/23/2012",22872573,"Hu L","08/07/2012","Clin Cancer Res","http://www.ncbi.nlm.nih.gov/pubmed/22872573","Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy.","Response to platinum-based chemotherapy in non-small-cell lung cancer","528 Han Chinese cases","340 Han Chinese cases, 409 European ancestry cases","5p14.1",5,26389262,"CDH9",null,4479,1007,null,475.88,491.45,"rs969088-C","rs969088",0,969088,null,1,"NR",3e-06,5.52287874528033,"(Han Chinese + EA)",1.4,"[1.22-1.61] ","NR [576,351]","N"]
["V2 (up-regulated)","10/23/2012",22872573,"Hu L","08/07/2012","Clin Cancer Res","http://www.ncbi.nlm.nih.gov/pubmed/22872573","Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy.","Response to platinum-based chemotherapy in non-small-cell lung cancer","528 Han Chinese cases","340 Han Chinese cases, 409 European ancestry cases","5p14.1",5,26389262,"CDH9",null,4479,1007,null,475.88,491.45,"rs969088-C","rs969088",0,969088,null,1,"NR",2e-06,5.69897000433601,"(Han Chinese)",1.43,"[1.24-1.66] ","NR [576,351]","N"]
["V2 (up-regulated)","09/29/2012",22883433,"Irish Schizophrenia Genomics Consortium & the Wellcome Trust Case Control Consortium 2","08/07/2012","Biol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22883433","Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia.","Schizophrenia","1,606 European ancestry cases, 1,794 European ancestry controls","13,195 European ancestry cases, 31,021 European ancestry controls","6p22.1",6,30165273,"MHC, TRIM26","- ",null,null,7726,null,null,"rs2523722-G","rs2523722",0,2523722,"intron",0,0.737,1e-16,16,null,1.25,"[1.12-1.39] ","Affymetrix [6,212,339]","N"]
["V2 (up-regulated)","09/20/2012",22823124,"Verweij KJ","07/24/2012","Addict Biol","http://www.ncbi.nlm.nih.gov/pubmed/22823124","The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.","Cannbis use (initiation)","10,091 individuals from 4,622 families","NR","6q25.3",6,158389741,"SYNJ2",null,51429,8871,null,23.63,13.15,"rs9458975-T","rs9458975",0,9458975,null,1,0.45,7e-06,5.15490195998574,null,0.03,"unit increase","Illumina [~2.4 million] (imputed)","N"]
["V2 (up-regulated)","08/15/2012",22705344,"Sobrin L","06/15/2012","Ophthalmology","http://www.ncbi.nlm.nih.gov/pubmed/22705344","Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes.","Age-related macular degeneration (CNV)","1,775 European ancestry CNV cases, 4,134 European ancestry controls","4,515 CNV cases, 15,240 controls","6p21.33",6,31914180,"CFB","- ",null,null,629,null,null,"rs641153-?","rs641153",0,641153,"missense",0,0.899,1e-17,17,null,2.22,"[1.85-2.63] ","Affymetrix & Illumina [6,036,699] (imputed)","N"]
["V2 (up-regulated)","08/15/2012",22705344,"Sobrin L","06/15/2012","Ophthalmology","http://www.ncbi.nlm.nih.gov/pubmed/22705344","Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes.","Age-related macular degeneration (GA)","819 European ancestry GA cases, 4,134 European ancestry controls",null,"6p21.33",6,31914180,"CFB","- ",null,null,629,null,null,"rs641153-?","rs641153",0,641153,"missense",0,0.899,2e-09,8.69897000433601,null,2.13,"[1.69-2.7] ","Affymetrix & Illumina [6,036,699] (imputed)","N"]
["V2 (up-regulated)","08/08/2012",22694956,"Cipriani V","06/13/2012","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/22694956","Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3.","Age-related macular degeneration","893 European ancestry cases, 2,199 European ancestry controls","1,411 European ancestry cases, 1,431 European ancestry controls","6p21.33",6,31916951,"CFB","- ",null,null,629,null,null,"rs541862-T","rs541862",0,541862,"intron",0,0.99,9e-17,16.0457574905606,null,1.89,"[1.61-2.17] ","Illumina [2,272,849] (imputed)","N"]
["V2 (up-regulated)","08/07/2012",22683712,"Freilinger T","06/10/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22683712","Genome-wide association analysis identifies susceptibility loci for migraine without aura.","Migraine","2,326 European ancestry cases, 4,580 European ancestry controls","2,508 European ancestry cases, 2,652 European ancestry controls","1q22",1,156456301,"MEF2D","- ",null,null,4209,null,null,"rs3790455-C","rs3790455",0,3790455,"intron",0,0.34,7e-11,10.1549019599857,null,1.2,"[1.14-1.27] ","Illumina [1,246,388] (imputed)","N"]
["V2 (up-regulated)","08/15/2012",22693459,"Li R","05/31/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22693459","Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.","Male-pattern baldness","3,891 European ancestry cases, 8,915 European ancestry controls","NR","20p11.22",20,22037575,"PAX1, FOXA2","- ",null,null,100270679,null,null,"rs6047844-T","rs6047844",0,6047844,"intron",0,0.46,2e-39,38.698970004336,null,1.6,"[1.49-1.72] ","Affymetrix & Illumina [2,391,230] (imputed)","N"]
["V2 (up-regulated)","08/15/2012",22581228,"Manning AK","05/13/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22581228","A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.","Fasting glucose-related traits (interaction with BMI)"," (up-regulated) to 58,074 European ancestry individuals"," (up-regulated) tp 38,422 European ancestry individuals","7p12.1",7,50751090,"GRB10","- ",null,null,2887,null,null,"rs10248619-?","rs10248619",0,10248619,"intron",0,"NR",8e-08,7.09691001300805,null,"NR","NR","Affymetrix & Illumina [~2.4 million] (imputed)","N"]
["V2 (up-regulated)","08/15/2012",22581228,"Manning AK","05/13/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22581228","A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.","Fasting glucose-related traits (interaction with BMI)"," (up-regulated) to 58,074 European ancestry individuals"," (up-regulated) tp 38,422 European ancestry individuals","20p11.21",20,22559601,"FOXA2","- ",null,null,140828,null,null,"rs6048205-?","rs6048205",0,6048205,"nearGene-5",0,"NR",2e-12,11.698970004336,null,"NR","NR","Affymetrix & Illumina [~2.4 million] (imputed)","N"]
["V2 (up-regulated)","08/17/2012",22589738,"Fox CS","05/10/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22589738","Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.","Subcutaneous adipose tissue","5,560 European ancestry women and 4,997 European ancestry men","NR","15q22.31",15,67066563,"SMAD6","- ",null,null,4091,null,null,"rs11858577-T","rs11858577",0,11858577,"intron",0,0.08,9e-06,5.04575749056067,"(overall)","NR","NR","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V2 (up-regulated)","08/17/2012",22589738,"Fox CS","05/10/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22589738","Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.","Visceral fat","5,560 European ancestry women and 4,997 European ancestry men","NR","5p14.1",5,26139138,"CDH9",null,4479,1007,null,225.75,741.57,"rs4701523-T","rs4701523",0,4701523,null,1,0.06,3e-06,5.52287874528033,"(men)","NR","NR","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V2 (up-regulated)","08/17/2012",22589738,"Fox CS","05/10/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22589738","Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.","Visceral fat","5,560 European ancestry women and 4,997 European ancestry men","NR","5p15.31",5,6599222,"NSUN2,SRD5A1","- ",null,null,54888,null,null,"rs6876835-A","rs6876835",0,6876835,"nearGene-3",0,0.58,3e-06,5.52287874528033,"(men)","NR","NR","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V2 (up-regulated)","07/04/2012",22542470,"Ovsyannikova IG","04/25/2012","Vaccine","http://www.ncbi.nlm.nih.gov/pubmed/22542470","Genome-wide association study of antibody response to smallpox vaccine.","Immune response to smallpox vaccine (IL-6)","217 African American ancestry individuals, 580 European ancestry individuals, 217 Hispanic ancestry individuals","NR","21q22.12",21,36238507,"RUNX1","- ",null,null,861,null,null,"rs2834655-?","rs2834655",0,2834655,"intron",0,"NR",5e-07,6.30102999566398,"(AA)","NR","NR","Illumina [NR]","N"]
["V2 (up-regulated)","04/11/2013",22504420,"Estrada K","04/15/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22504420","Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.","Bone mineral density"," (up-regulated) to 32,961 European and East Asian ancestry individuals"," (up-regulated) to 50,933 European and East Asian ancestry individuals","7p12.1",7,50754679,"GRB10","- ",null,null,2887,null,null,"rs2282930-A","rs2282930",0,2282930,"intron",0,0.24,3e-06,5.52287874528033,"(FNBMD)",0.03,"[NR] unit decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V2 (up-regulated)","05/25/2012",22493691,"Eriksson N","04/06/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/22493691","Novel associations for hypothyroidism include known autoimmune risk loci.","Hypothyroidism","3,736 European ancestry cases, 35,546 European ancestry controls","NR","17q12",17,32464154,"LOC100131744, CCL2","- ",null,null,40,null,null,"rs9901756-A","rs9901756",0,9901756,"intron",0,0.893,7e-06,5.15490195998574,null,1.21,"[1.11-1.32] ","Illumina [870,065]","N"]
["V2 (up-regulated)","05/11/2012",22472876,"Major Depressive Disorder Working Gro (up-regulated) of the Psychiatric GWAS Consortium","04/03/2012","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22472876","A mega-analysis of genome-wide association studies for major depressive disorder.","Major depressive disorder","9,240 European ancestry cases, 9,519 European ancestry controls","6,783 European ancestry cases, 50,695 European ancestry controls","16q24.2",16,87461969,"FBXO31,MAP1LC3B,ZCCHC14","- ",null,null,23174,null,null,"rs9646303-?","rs9646303",0,9646303,"intron",0,"NR",5e-06,5.30102999566398,null,"NR","NR","Affymetrix, Illumina & Perlegen [~1.2 million](imputed)","N"]
["V2 (up-regulated)","04/03/2012",22412388,"Kenny EE","03/08/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22412388","A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.","Crohn's disease","737 Ashkenazi Jewish cases, 2,257  Ashkenazi Jewish controls","971 Ashkenazi Jewish cases, 2,124 Ashkenazi Jewish controls","5q31.1",5,131402738,"IL3, ACSL6, P4HA2, PDLIM4, SLC22A4",null,3562,1437,null,3.84,6.75,"rs3091338-T","rs3091338",0,3091338,null,1,0.328,4e-08,7.39794000867203,null,1.23,"[1.08-1.42] ","Affyemtrix & Illumina [1,060,934] (imputed)","N"]
["V2 (up-regulated)","04/03/2012",22412388,"Kenny EE","03/08/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22412388","A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.","Crohn's disease","737 Ashkenazi Jewish cases, 2,257  Ashkenazi Jewish controls","971 Ashkenazi Jewish cases, 2,124 Ashkenazi Jewish controls","17q12",17,32593974,"CCL7, CCL2, CCL11, CCL8, CCL13, CCL1",null,6347,6354,null,9.75,3.27,"rs3091316-G","rs3091316",0,3091316,null,1,0.732,4e-08,7.39794000867203,null,1.14,"[1.03-1.27] ","Affyemtrix & Illumina [1,060,934] (imputed)","N"]
["V2 (up-regulated)","04/03/2012",22412388,"Kenny EE","03/08/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22412388","A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.","Crohn's disease","737 Ashkenazi Jewish cases, 2,257  Ashkenazi Jewish controls","971 Ashkenazi Jewish cases, 2,124 Ashkenazi Jewish controls","16q22.1",16,67971380,"PSMB10","- ",null,null,5699,null,null,"rs11574514-A","rs11574514",0,11574514,"nearGene-5",0,0.045,2e-07,6.69897000433601,null,1.44,"[1.35-1.52] ","Affyemtrix & Illumina [1,060,934] (imputed)","N"]
["V2 (up-regulated)","03/30/2012",22365631,"Greenwood TA","02/22/2012","Biol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22365631","Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci.","Temperament (bipolar disorder)","1,263 European ancestry cases and 1,434 European ancestry controls","NR","22q13.31",22,45961904,"FBLN1","- ",null,null,2192,null,null,"rs1985671-?","rs1985671",0,1985671,"intron",0,"NR",2e-08,7.69897000433601,"(Hyperthymic)",1.06,"[NR] unit decrease","Affymetrix [703,012]","N"]
["V2 (up-regulated)","02/28/2012",22286219,"Kettunen J","01/29/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22286219","Genome-wide association study identifies multiple loci influencing human serum metabolite levels.","Metabolite levels","8,330 European ancestry individuals","NR","2p14",2,65220910,"SLC1A4","- ",null,null,6509,null,null,"rs2160387-?","rs2160387",0,2160387,"intron",0,"NR",3e-22,21.5228787452803,"(Ala, Val)",0.17,"[0.13-0.21] unit decrease","Illumina [~7.7 million] (imputed)","N"]
["V2 (up-regulated)","02/07/2012",22238593,"Palmer ND","01/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/22238593","A genome-wide association search for type 2 diabetes genes in African Americans.","Type 2 diabetes","965 African American ancestry cases, 1,029 African American ancestry controls","2,167 African American ancestry cases, 2,288 African American ancestry controls","1p21.3",1,95070041,"SLC44A3, F3",null,2152,100421182,null,62.63,68.44,"rs7542900-C","rs7542900",0,7542900,null,1,0.56,6e-06,5.22184874961635,null,1.16,"[1.09-1.25] ","Affymetrix [832,357]","N"]
["V2 (up-regulated)","11/16/2012",22139419,"Gieger C","11/30/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/22139419","New gene functions in megakaryopoiesis and platelet formation.","Mean platelet volume","18,600 European ancestry individuals"," (up-regulated) to 18,838 European ancestry individuals","4p16.1",4,6891519,"KIAA0232",null,9778,57533,null,5.62,19.65,"rs11734132-G","rs11734132",0,11734132,null,1,"NR",1e-11,11,null,0.01,"[0.0071-0.0149] ln(fl) increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V2 (up-regulated)","11/16/2012",22139419,"Gieger C","11/30/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/22139419","New gene functions in megakaryopoiesis and platelet formation.","Platelet counts","48,666 individuals of European ancestry"," (up-regulated) to 18,838 individuals of European ancestry","22q11.21",22,19984277,"ARVCF","- ",null,null,421,null,null,"rs1034566-T","rs1034566",0,1034566,"intron",0,"NR",3e-08,7.52287874528033,null,2.13,"[1.38-2.88] 10^9/l increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V2 (up-regulated)","12/16/2011",22075330,"Granada M","11/08/2011","J Allergy Clin Immunol","http://www.ncbi.nlm.nih.gov/pubmed/22075330","A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.","IgE levels ","6,819 European ancestry individuals","7,809 European ancestry indivduals","12q13.3",12,57489709,"STAT6, NAB2","- ",null,null,"4665;6778",null,null,"rs1059513-C","rs1059513",0,1059513,"nearGene-3;ncRNA",0,"NR",2e-12,11.698970004336,null,0.12,"[NR] unit decrease","Affymetrix [2,540,223] (imputed)","N"]
["V2 (up-regulated)","12/01/2011",22036096,"Ramasamy A","11/01/2011","J Allergy Clin Immunol","http://www.ncbi.nlm.nih.gov/pubmed/22036096","A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.","Allergic rhinitis","3,933 European ancestry cases, 8,965 European ancestry controls","NR","11q13.5",11,76299194,"C11orf30, LRRC32",null,56946,2615,null,36.61,69.37,"rs2155219-T","rs2155219",0,2155219,null,1,0.47,4e-08,7.39794000867203,null,1.17,"[1.11-1.24] ","Affymetrix & Illumina  [2,217,510] (imputed)","N"]
["V2 (up-regulated)","12/01/2011",22036096,"Ramasamy A","11/01/2011","J Allergy Clin Immunol","http://www.ncbi.nlm.nih.gov/pubmed/22036096","A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.","IgE grass sensitization","2,315 Caucasian cases, 10,032 Caucasian controls","NR","11q13.5",11,76299194,"C11orf30, LRRC32",null,56946,2615,null,36.61,69.37,"rs2155219-T","rs2155219",0,2155219,null,1,0.47,1e-08,8,null,1.22,"[1.14-1.31] ","Affymetrix & Illumina [2,217,510] (imputed)","N"]
["V2 (up-regulated)","11/30/2011",22012869,"Hinney A","10/19/2011","Am J Med Genet B Neuropsychiatr Genet","http://www.ncbi.nlm.nih.gov/pubmed/22012869","Genome-wide association study in German patients with attention deficit/hyperactivity disorder.","Attention deficit hyperactivity disorder","495 European ancestry child and adolescent cases, 1,300 European ancestry adult controls","1023 individuals (from 320 families with at least one affected child), 896 controls and 2455 cases (from 2064 trios)","2p16.1",2,60762502,"BCL11A","- ",null,null,53335,null,null,"rs2556378-T","rs2556378",0,2556378,"intron",0,"NR",7e-06,5.15490195998574,null,"NR","NR","Illumina [487,484]","N"]
["V2 (up-regulated)","10/26/2011",21980299,"Bradfield JP","09/29/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21980299","A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.","Type 1 diabetes","9,934 European ancestry cases, 16,956 European ancestry controls","1,120 European ancestry affected trios","2p23.3",2,25301755,"EFR3B, 3NCOA1, C2orf79, CENPO, ADCY3, DNAJC27, POMC, DNMT3A","- ",null,null,22979,null,null,"rs478222-?","rs478222",0,478222,"intron",0,0.59,4e-09,8.39794000867203,null,1.22,"[NR] ","Affymetrix & Illumina [~2.54 million] (imputed)","N"]
["V2 (up-regulated)","10/17/2011",21926974,"Ripke S","09/18/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21926974","Genome-wide association study identifies five new schizophrenia loci.","Schizophrenia","9,394 European ancestry cases, 12,462 European ancestry controls","8,442 European ancestry cases, 21,397 European ancestry controls","6p22.1",6,30174131,"TRIM26","- ",null,null,7726,null,null,"rs2021722-C","rs2021722",0,2021722,"intron",0,0.78,2e-12,11.698970004336,null,1.15,"[1.11-1.19] ","Affymetrix & Illumina [1,252,901] (imputed)","N"]
["V2 (up-regulated)","09/30/2011",21907864,"Ferreira MA","09/10/2011","Lancet","http://www.ncbi.nlm.nih.gov/pubmed/21907864","Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.","Asthma","12,475 European ancestry cases, 19,967 European ancestry controls","3,322 European ancestry cases, 22,036 European ancestry controls","11q13.5",11,76270683,"LRRC32",null,56946,2615,null,8.09,97.89,"rs7130588-G","rs7130588",0,7130588,null,1,0.34,2e-08,7.69897000433601,null,1.09,"[1.06-1.13] ","Illumina [NR] (imputed)","N"]
["V2 (up-regulated)","02/24/2012",21886157,"Suhre K","08/31/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21886157","Human metabolic individuality in biomedical and pharmaceutical research.","Metabolic traits","2,820 European ancestry individuals","NR","5q31.1",5,131665378,"SLC22A4","- ",null,null,"6583;553103",null,null,"rs272889-A","rs272889",0,272889,"intron;intron",0,0.37,7e-16,15.1549019599857,"(isovalerylcarnitine + 7 other traits)",0.08,"[NR] unit increase","Affmyetrix & Illumina [534,665] ","N"]
["V2 (up-regulated)","09/28/2011",21874001,"Kooner JS","08/28/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21874001","Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.","Type 2 diabetes","5,561 South Asian ancestry cases, 14,458 South Asian ancestry controls","13,170 South Asian ancestry cases, 25,398 South Asian ancestry controls","15q26.1",15,90374257,"AP3S2","- ",null,null,"10239;100526783",null,null,"rs2028299-C","rs2028299",0,2028299,"ncRNA;UTR-3",0,0.31,2e-11,10.698970004336,null,1.1,"[1.07-1.13] ","Illumina [568,976]","N"]
["V2 (up-regulated)","10/24/2012",21833088,"Sawcer S","08/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21833088","Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.","Multiple sclerosis","9,772 European ancestry cases, 16,849 European ancestry controls","4,218 European ancestry cases, 7,296 European ancestry controls","3p24.3",3,16970938,"PLCL2","- ",null,null,23228,null,null,"rs9821630-G","rs9821630",0,9821630,"intron",0,"NR",4e-06,5.39794000867203,null,1.08,"[1.07-1.1] ","Illumina [465,434]","N"]
["V2 (up-regulated)","09/17/2011",21824976,"Garcia-Closas M","08/08/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21824976","A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3.","Bladder cancer","4,501 European ancestry cases, 6,076 European ancestry controls","1,382 European ancestry cases, 2,201 European ancestry controls","18q12.3",18,43316966,"SLC14A1","- ",null,null,6563,null,null,"rs7238033-?","rs7238033",0,7238033,"intron",0,"NR",9e-09,8.04575749056067,null,1.2,"[1.13-1.28] ","Illumina [555,912]","N"]
["V2 (up-regulated)","09/08/2011",21810271,"Antoni G","08/02/2011","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/21810271","Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels.","vWF and FVIII levels","1,624 European ancestry individuals","NR","17q11.2",17,31737421,"ACCN1","- ",null,null,40,null,null,"rs1354492-A","rs1354492",0,1354492,"intron",0,0.49,2e-06,5.69897000433601,"(FVIII activity)",0.16,"[0.10-0.22] IU/dL increase","Illumina [442,728]","N"]
["V2 (up-regulated)","09/01/2011",21829377,"Lemaitre RN","07/28/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21829377","Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.","Phospholipid levels (plasma)","8,866 European ancestry individuals","NR","21q22.12",21,36416332,"RUNX1","- ",null,null,861,null,null,"rs9983044-C","rs9983044",0,9983044,"intron",0,"NR",2e-07,6.69897000433601,"(EPA)",0.07,"[NR] % increase","Affymetrix & Illumina [NR]","N"]
["V2 (up-regulated)","08/12/2011",21779181,"Gorlova O","07/14/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21779181","Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.","Systemic sclerosis","2,296 European ancestry cases, 5,172 European ancestry controls","3,175 European ancestry cases, 4,210 European ancestry controls","7p12.1",7,50664922,"GRB10","- ",null,null,2887,null,null,"rs12540874-?","rs12540874",0,12540874,"intron",0,0.4,1e-06,5.99999999999999,"(IcSSc)",1.15,"[1.09-1.22] ","Illumina [NR] (imputed)","N"]
["V2 (up-regulated)","08/05/2011",21750109,"Rafnar T","07/12/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21750109","European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene.","Bladder cancer","2,234 European ancestry cases, 41,603 European ancestry controls","3,371 European ancestry cases, 10,261 European ancestry controls, 269 Iranian cases, 246 Iranian controls","18q12.3",18,43309911,"SLC14A1","- ",null,null,6563,null,null,"rs17674580-T","rs17674580",0,17674580,"intron",0,0.33,8e-11,10.096910013008,null,1.17,"[1.11-1.22] ","Illumina [5,340,737] (imputed)","N"]
["V2 (up-regulated)","06/29/2011",21665990,"Yu Y","06/10/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21665990","Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.","Age-related macular degeneration","2,594 European ancestry cases, 4,134 European ancestry controls","5,640 cases, 52,174 controls","6p21.33",6,31914180,"CFB","- ",null,null,629,null,null,"rs641153-?","rs641153",0,641153,"missense",0,0.9,6e-31,30.2218487496163,null,1.85,"[NR] ","Affymetrix [6,036,699] (imputed)","N"]
["V2 (up-regulated)","06/25/2011",21654844,"Briggs FB","06/09/2011","Genes Immun","http://www.ncbi.nlm.nih.gov/pubmed/21654844","Genome-wide association study of severity in multiple sclerosis.","Multiple sclerosis","1,470 European ancestry cases","NR","4q31.3",4,154154000,"TRIM2","- ",null,null,23321,null,null,"rs12644284-?","rs12644284",0,12644284,"intron",0,0.67,4e-06,5.39794000867203,"(Extreme)",2.04,"[NR] ","Affymetrix [2,110,417] (imputed)","N"]
["V2 (up-regulated)","06/16/2011",21642993,"Wu C","06/05/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21642993","Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.","Esophageal cancer","2,031 Han Chinese cases, 2,044 Han Chinese controls","3,986 Han Chinese cases, 4,157 Han Chinese controls","21q22.12",21,36357861,"RUNX1","- ",null,null,861,null,null,"rs2014300-G","rs2014300",0,2014300,"intron",0,0.83,8e-22,21.096910013008,null,1.43,"[1.33-1.54] ","Affymetrix [666,141]","N"]
["V2 (up-regulated)","05/26/2011",21493818,"Shaw SY","04/21/2011","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/21493818","Genetic and clinical correlates of early-outgrowth colony-forming units.","Monocyte early outgrowth colony forming units","1,654 European ancestry individuals","NR","2p16.1",2,60281608,"BCL11A",null,400955,100616473,null,990.71,332.89,"rs6712720-C","rs6712720",0,6712720,null,1,0.49,4e-06,5.39794000867203,null,0.16,"[0.08-0.24] unit increase","Affymetrix [~2.5 million] (imputed)","N"]
["V2 (up-regulated)","05/25/2011",21502573,"Smith NL","04/21/2011","Circulation","http://www.ncbi.nlm.nih.gov/pubmed/21502573","Genetic predictors of fibrin D-dimer levels in healthy adults.","D-dimer levels","21,052 European ancestry individuals","NR","1p21.3",1,95053353,"F3",null,2152,100421182,null,45.94,85.12,"rs12029080-G","rs12029080",0,12029080,null,1,0.31,6e-52,51.2218487496163,null,10.4,"[6.6-14.3] % increase","Affymetrix & Illumina [2,522,393] (imputed)","N"]
["V2 (up-regulated)","05/25/2011",21502573,"Smith NL","04/21/2011","Circulation","http://www.ncbi.nlm.nih.gov/pubmed/21502573","Genetic predictors of fibrin D-dimer levels in healthy adults.","D-dimer levels","21,052 European ancestry individuals","NR","11p11.2",11,47127153,"C11orf49","- ",null,null,79096,null,null,"rs7117404-G","rs7117404",0,7117404,"intron",0,0.153,9e-06,5.04575749056067,null,0.04,"[NR] % decrease","Affymetrix & Illumina [2,522,393] (imputed)","N"]
["V2 (up-regulated)","04/12/2011",21399633,"Gharavi AG","03/13/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21399633","Genome-wide association study identifies susceptibility loci for IgA nephropathy.","Nephropathy","1,194 Chinese ancestry cases, 902 Chinese ancestry controls","712 Chinese ancestry cases, 748 Chinese ancestry controls, 1,238 European ancestry cases, 1,172 European ancestry controls","22q12.2",22,30494371,"HORMAD2, MTMR3, LIF, OSM","- ",null,null,150280,null,null,"rs2412971-?","rs2412971",0,2412971,"intron",0,"0.49 (EA)",2e-09,8.69897000433601,null,1.25,"[NR] ","Illumina [498,322]","N"]
["V2 (up-regulated)","04/12/2011",21399635,"Mells GF","03/13/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21399635","Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.","Primary biliary cirrhosis","2,774 European ancestry cases, 9,814 European ancestry controls","620 European ancestry cases, 2,514 European ancestry controls","3p24.3",3,16955259,"PLCL2","- ",null,null,23228,null,null,"rs1372072-A","rs1372072",0,1372072,"intron",0,0.37,2e-08,7.69897000433601,null,1.2,"[1.12-1.27] ","Illumina [507,467]","N"]
["V2 (up-regulated)","04/04/2011",21326311,"Bhatnagar P","02/17/2011","J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/21326311","Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.","F-cell distribution","440 African ancestry individuals","NR","2p16.1[rs10189857]; 2p16.1[rs6545816]",null,null,"BCL11A","- ",{"$nulls":5},"20-SNP haplotype cluster 2","rs10189857, rs6545816, rs6545817, rs1427407, rs7599488, rs1896294, rs766432, rs11886868, rs10195871, rs10172646, rs4671393, rs7584113, rs7557939, rs6706648, rs6738440, rs7565301, rs6729815, rs1896295, rs1896296, rs7606173",{"$nulls":4},0.42,2e-07,null,null,1.07,"[0.68-1.46] unit increase","Illumina [660,740]","N"]
["V2 (up-regulated)","04/04/2011",21326311,"Bhatnagar P","02/17/2011","J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/21326311","Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.","F-cell distribution","440 African ancestry individuals","NR","2p16.1[rs10189857]; 2p16.1[rs6545816]",null,null,"BCL11A","- ",{"$nulls":5},"20-SNP haplotype cluster 3","rs10189857, rs6545816, rs6545817, rs1427407, rs7599488, rs1896294, rs766432, rs11886868, rs10195871, rs10172646, rs4671393, rs7584113, rs7557939, rs6706648, rs6738440, rs7565301, rs6729815, rs1896295, rs1896296, rs7606173",{"$nulls":4},0.254,2e-16,null,null,1.98,"[1.57-2.39] unit increase","Illumina [660,740]","N"]
["V2 (up-regulated)","03/29/2011",21297633,"Anderson CA","02/06/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21297633","Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.","Ulcerative colitis","6,687 European ancestry cases, 19,718 European ancestry controls","9,628 European ancestry cases, 12,917 European ancestry controls","1p36.23",1,8021973,"TNFRSF9, ERFFI1, UTS2, PARK7","- ",null,null,11315,null,null,"rs35675666-G","rs35675666",0,35675666,"intron",0,0.83,5e-09,8.30102999566398,null,1.08,"[1.02-1.15] ","Affymetrix & Illumina [~1.1 million] (imputed)","N"]
["V2 (up-regulated)","01/10/2011",21105107,"Clifford RJ","12/01/2010","Hepatology","http://www.ncbi.nlm.nih.gov/pubmed/21105107","Genetic variations at loci involved in the immune response are risk factors for hepatocellular carcinoma.","Hepatocellular carcinoma","180 Korean hepatocellular carcinoma cases, 271 Korean controls","206 Korean hepatocellular carcinoma cases, 316 Korean controls, 100 Chinese controls","14q32.11",14,90301035,"C14orf143","- ",null,null,90141,null,null,"rs12100561-?","rs12100561",0,12100561,"intron",0,0.39,4e-06,5.39794000867203,null,1.52,"[1.26-1.83] ","Affymetrix [658,897]","N"]
["V2 (up-regulated)","01/08/2011",21102462,"Elks CE","11/21/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21102462","Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.","Menarche (age at onset)","87,802 European ancestry women"," (up-regulated) to 14,731 women","13q34",13,112181437,"C13orf16, ARHGEF7",null,121793,6656,null,184.84,540.48,"rs9555810-G","rs9555810",0,9555810,null,1,0.28,6e-08,7.22184874961635,null,2.3,"[1.52-3.08] week decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V2 (up-regulated)","10/19/2012",21102463,"Franke A","11/21/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21102463","Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.","Crohn's disease","6,333 European ancestry cases, 15,056 European ancestry controls","15,694 European ancestry cases, 14,026 European ancestry controls, 414 European ancestry parent-offspring trios","17q12",17,32593665,"CCL2,CCL7",null,6347,6354,null,9.44,3.58,"rs3091315-A","rs3091315",0,3091315,null,1,0.723,2e-13,12.698970004336,null,1.2,"[1.14-1.26] ","Affymetrix & Illumina [953,241] (imputed)","N"]
["V2 (up-regulated)","10/19/2012",21102463,"Franke A","11/21/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21102463","Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.","Crohn's disease","6,333 European ancestry cases, 15,056 European ancestry controls","15,694 European ancestry cases, 14,026 European ancestry controls, 414 European ancestry parent-offspring trios","3p21.31",3,49721532,"MST1,GPX1,BSN","- ",null,null,4485,null,null,"rs3197999-A","rs3197999",0,3197999,"missense",0,0.297,6e-17,16.2218487496163,null,1.22,"[1.16-1.27] ","Affymetrix & Illumina [953,241] (imputed)","N"]
["V2 (up-regulated)","10/19/2012",21102463,"Franke A","11/21/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21102463","Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.","Crohn's disease","6,333 European ancestry cases, 15,056 European ancestry controls","15,694 European ancestry cases, 14,026 European ancestry controls, 414 European ancestry parent-offspring trios","5q31.1",5,131784393,"SLC22A4,SLC22A5,IRF1,IL3","- ",null,null,441108,null,null,"rs12521868-T","rs12521868",0,12521868,"intron",0,0.422,1e-20,20,null,1.23,"[1.18-1.28] ","Affymetrix & Illumina [953,241] (imputed)","N"]
["V2 (up-regulated)","01/07/2011",21095009,"Li YJ","11/20/2010","Ophthalmology","http://www.ncbi.nlm.nih.gov/pubmed/21095009","Genome-wide association studies reveal genetic variants in CTNND2 for high myopia in Singapore Chinese.","Myopia (pathological)","65 Chinese child cases, 238 Chinese child controls, 222 Chinese adult cases, 455 Chinese adult cases","959 Japanese high myopia cases, 2,128 Japanese controls","5p15.2",5,11169945,"CTNND2","- ",null,null,1501,null,null,"rs6885224-C","rs6885224",0,6885224,"intron",0,0.26,8e-06,5.09691001300805,null,1.24,"[1.11-1.39] ","Illumina [459,687]","N"]
["V2 (up-regulated)","01/06/2011",21079607,"Wang K","11/16/2010","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/21079607","A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa.","Anorexia nervosa","1,033 European ancestry cases, 3,773 European ancestry pediatric controls","NR","5p14.1",5,26723783,"CDH9",null,4479,1007,null,810.4,156.93,"rs4479806-?","rs4479806",0,4479806,null,1,0.1,8e-06,5.09691001300805,null,"NR","NR","Illumina [~598,000]","N"]
["V2 (up-regulated)","01/11/2011",21057379,"Curtis D","11/04/2010","Psychiatr Genet","http://www.ncbi.nlm.nih.gov/pubmed/21057379","Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes.","Bipolar disorder and schizophrenia","506 European bipolar 1 disorder cases, 523 European schizophrenia cases, 505 European controls","NR","17q24.2",17,64917033,"CACNG5",null,27091,27092,null,35.64,43.95,"rs17645023-?","rs17645023",0,17645023,null,1,"NR",6e-07,6.22184874961635,null,"NR","NR","Affymetrix [302,482]","N"]
["V2 (up-regulated)","11/17/2010",20935630,"Speliotes EK","10/10/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20935630","Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.","Body mass index"," (up-regulated) to 123,865 European ancestry individuals"," (up-regulated) to 125,931 European ancestry individuals","16p13.3",16,4038387,"ADCY9","- ",null,null,115,null,null,"rs2444217-A","rs2444217",0,2444217,"intron",0,0.57,9e-08,7.04575749056067,null,"NR","NR","Affymetrix, Illumina and Perlegen [~2.8 million] (imputed)","N"]
["V2 (up-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","2q36.1",2,225047744,"SERPINE2",null,5270,79843,null,143.71,195.67,"rs2629046-T","rs2629046",0,2629046,null,1,0.55,8e-12,11.096910013008,null,0.02,"[NR] unit increase","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V2 (up-regulated)","09/28/2010",20838585,"Smith EN","09/09/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20838585","Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study.","Cardiovascular disease risk factors","525 European ancestry individuals","2,265 Finnish individuals","11q23.3",11,116613660,"CADM1,BUD13,APOA5",null,100128347,84811,null,792.14,5.23,"rs12280753-T","rs12280753",0,12280753,null,1,0.07,8e-06,5.09691001300805,"(triglycerides)",0.69,"[0.40-0.98] % SD increase, SNPxAGE interaction","Illumina [545,821]","N"]
["V2 (up-regulated)","09/21/2010",20705733,"O'Seaghdha CM","08/12/2010","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/20705733","Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.","Calcium levels","20,611 European ancestry individuals","NR","11p15.4",11,2953723,"SLC22A18,PHLDA2,CDKN1C,NAP1L4",null,7262,677833,null,3.07,31.28,"rs3847646-T","rs3847646",0,3847646,null,1,"NR",5e-06,5.30102999566398,null,0.03,"[NR] unit decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V2 (up-regulated)","09/15/2010",20700443,"Meyer TE","08/05/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20700443","Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels.","Magnesium levels","15,366 European descent individuals","8,463 European descent individuals","9q21.13",9,77499796,"TRPM6","- ",null,null,140803,null,null,"rs11144134-T","rs11144134",0,11144134,"intron",0,0.92,8e-15,14.096910013008,null,0.01,"[0.009-0.013] mmol/L decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V2 (up-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","Triglycerides"," (up-regulated) to 96,598 European descent individuals",null,"10q23.33",10,94839642,"CYP26A1",null,1592,643863,null,2,204.08,"rs2068888-A","rs2068888",0,2068888,null,1,0.47,2e-08,7.69897000433601,null,2.28,"[1.54-3.02] mg/dL decrease","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V2 (up-regulated)","07/12/2010",20581827,"Voight BF","06/27/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20581827","Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.","Type 2 diabetes","8,130 European ancestry cases, 38,987 European ancestry controls"," (up-regulated) to 34,412 European ancestry cases, 59,925 European ancestry controls","2p16.1",2,60584819,"BCL11A",null,400955,100616473,null,1293.92,29.68,"rs243021-A","rs243021",0,243021,null,1,"NR",3e-15,14.5228787452803,null,1.08,"[1.06-1.10] ","Affymetrix & Illumina [2,426,886] (imputed)","N"]
["V2 (up-regulated)","06/22/2010",20522523,"Kasperaviciute D","06/03/2010","Brain","http://www.ncbi.nlm.nih.gov/pubmed/20522523","Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.","Partial epilepsies"," (up-regulated) to 3,445 European ancestry cases, 6,935 European ancestry controls","NR","16p13.3",16,4103871,"ADCY9","- ",null,null,115,null,null,"rs2601828-A","rs2601828",0,2601828,"intron",0,0.222,1e-06,5.99999999999999,null,1.12,"[1.12-1.31] ","Illumina [528,745]","N"]
["V2 (up-regulated)","05/10/2010",20205591,"Pelak K","04/15/2010","J Infect Dis","http://www.ncbi.nlm.nih.gov/pubmed/20205591","Host determinants of HIV-1 control in African Americans.","HIV-1 control","515 African American cases","NR","8p21.3",8,22400989,"PPP3CC",null,652964,10174,null,50.1,8.26,"rs4872511-?","rs4872511",0,4872511,null,1,0.01,9e-06,5.04575749056067,null,"NR","NR","Illumina [1,212,217]","N"]
["V2 (up-regulated)","05/06/2010",20385819,"Chen W","04/12/2010","Proc Natl Acad Sci U S A","http://www.ncbi.nlm.nih.gov/pubmed/20385819","Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.","Age-related macular degeneration","2,978 European ancestry cases, 2,859 European ancestry controls","7,071 European ancestry cases, 678 Japanese cases, 4,289 European ancestry controls, 336 Japanese controls","6p21.33",6,31930462,"C2,CFB","- ",null,null,6499,null,null,"rs429608-G","rs429608",0,429608,"intron",0,0.842,3e-21,20.5228787452803,null,2.16,"[1.84-2.53] ","Illumina [~2.5 million] (imputed)","N"]
["V2 (up-regulated)","05/06/2010",20385819,"Chen W","04/12/2010","Proc Natl Acad Sci U S A","http://www.ncbi.nlm.nih.gov/pubmed/20385819","Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.","Age-related macular degeneration","2,978 European ancestry cases, 2,859 European ancestry controls","7,071 European ancestry cases, 678 Japanese cases, 4,289 European ancestry controls, 336 Japanese controls","6p21.33",6,31906010,"C2,CFB","- ",null,null,717,null,null,"rs9380272-A","rs9380272",0,9380272,"intron",0,0.012,2e-08,7.69897000433601,null,4.31,"[2.76-6.87] ","Illumina [~2.5 million] (imputed)","N"]
["V2 (up-regulated)","05/06/2010",20385826,"Neale BM","04/12/2010","Proc Natl Acad Sci U S A","http://www.ncbi.nlm.nih.gov/pubmed/20385826","Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).","Age-related macular degeneration","979 European ancestry cases, 1,709 European ancestry controls","5,789 Caucasian cases, 4,234 Caucasian controls","6p21.33",6,31914180,"CFB,C2","- ",null,null,629,null,null,"rs641153-?","rs641153",0,641153,"missense",0,"NR",2e-20,19.698970004336,null,"NR","NR","Affymetrix [632,932]","N"]
["V2 (up-regulated)","05/03/2010",20360315,"Uher R","04/01/2010","Am J Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/20360315","Genome-wide pharmacogenetics of antidepressant response in the GENDEP project.","Response to antidepressants","706 European descent individuals","NR","1q25.3",1,183837032,"RGL1","- ",null,null,23179,null,null,"rs4651156-?","rs4651156",0,4651156,"intron",0,0.29,3e-06,5.52287874528033,"(nortriptyline)",12.6,"[NR] % worse outcome","Illumina [539,391]","N"]
["V2 (up-regulated)","03/29/2010",20190752,"Dubois PC","02/28/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20190752","Multiple common variants for celiac disease influencing immune gene expression.","Celiac disease","4,533 European descent cases, 10,750 European descent controls","4,918 European descent cases, 5,684 European descent controls","1p36.23",1,8046672,"PARK7, TNFRSF9",null,11315,54206,null,1.33,25.11,"rs12727642-A","rs12727642",0,12727642,null,1,0.19,9e-08,7.04575749056067,null,1.14,"[1.09-1.20] ","Illumina [292,387]","N"]
["V2 (up-regulated)","02/28/2010",20101243,"Petersen GM","01/24/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20101243?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=11","A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.","Pancreatic cancer","3,851 cases, 3,934 controls","NR","13q22.1",13,73916628,"KLF5, KLF12",null,100873807,100421565,null,115.23,65.3,"rs9543325-C","rs9543325",0,9543325,null,1,0.37,3e-11,10.5228787452803,null,1.26,"[1.18-1.35] ","Illumina [551,766]","N"]
["V2 (up-regulated)","01/21/2010",20062064,"Crowther-Swanepoel D","01/10/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20062064?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk.","Chronic lymphocytic leukemia","505 European cases, 1,438 European controls","1,998 European cases, 4,351 European controls","15q25.2",15,83254708,"CPEB1","- ",null,null,64506,null,null,"rs783540-G","rs783540",0,783540,"intron",0,"NR",4e-06,5.39794000867203,null,1.18,"[1.10-1.27] ","Illumina [299,983]","N"]
["V2 (up-regulated)","12/28/2009",20183929,"Nuinoon M","11/19/2009","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/20183929","A genome-wide association identified the common genetic variants influence disease severity in beta0-thalassemia/hemoglobin E.","Beta thalassemia/hemoglobin E disease","235 mild Thai-Chinese cases, 383 severe Thai-Chinese cases","52 mild Indonesian cases, 122 severe Indonesian cases","2p16.1",2,60719970,"BCL11A","- ",null,null,53335,null,null,"rs766432-?","rs766432",0,766432,"intron",0,0.24,1e-10,10,null,2.8,"[2.04-3.84] ","Illumina [548,094]","N"]
["V2 (up-regulated)","11/03/2009",19862010,"Ganesh SK","10/11/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19862010?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.","Mean corpuscular volume","24,167 European ancestry individuals","9,456 European ancestry individuals","2p16.1",2,60608759,"BCL11A",null,400955,100616473,null,1317.86,5.74,"rs2540917-C","rs2540917",0,2540917,null,1,"NR",1e-14,14,null,0,"[0.002-0.004] fl decrease","Affymetrix & Illumina [~2.5 million](imputed)","N"]
["V2 (up-regulated)","11/08/2012",19734545,"Need AC","09/04/2009","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19734545?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.","Cognitive performance"," (up-regulated) to 1,295 individuals","NR","4p13",4,41284711,"UCHL1",null,7345,100270923,null,14.27,106.42,"rs4861096-?","rs4861096",0,4861096,null,1,0.244,9e-06,5.04575749056067,"(PAL6)","NR","NR","Illumina [475,971]","N"]
["V2 (up-regulated)","11/08/2012",19734545,"Need AC","09/04/2009","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19734545?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.","Cognitive performance"," (up-regulated) to 1,295 individuals","NR","21q21.3",21,27002377,"JAM2",null,54148,100421428,null,22.58,13.48,"rs17001239-?","rs17001239",0,17001239,null,1,0.1166,2e-06,5.69897000433601,"(PRM)","NR","NR","Illumina [475,971]","N"]
["V2 (up-regulated)","12/29/2009",20031603,"Marroni F","08/01/2009","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/20031603","A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.","QT interval","2,325 European ancestry individuals","NR","14q32.13",14,96122408,"TCL6","- ",null,null,27004,null,null,"rs8015016-G","rs8015016",0,8015016,"intron",0,0.2,5e-07,6.30102999566398,null,0.18,"[0.10-0.26] unit decrease","Illumina [~318,327]","N"]
["V2 (up-regulated)","07/10/2009",19571809,"Shi J","07/01/2009","Nature","http://www.ncbi.nlm.nih.gov/pubmed/19571809","Common variants on chromosome 6p22.1 are associated with schizophrenia.","Schizophrenia","2,681 European ancestry cases, 2,653 European ancestry controls, 1,286 African American cases, 973 African American controls","5,327 European ancestry cases, 16,424 European ancestry controls","6p22.1",6,27143883,"SLC17A1, SLC17A3, BTN3A2, BTN2A2, BTN3A1, HIST1H2AG, HIST1H2BJ, PRSS16, POM121L2, ZNF184",null,100422934,442171,null,28.42,35.14,"rs13194053-T","rs13194053",0,13194053,null,1,0.82,1e-08,8,"(EA)",1.28,"[NR] ","Affymetrix [ (up-regulated) to 843,798]","N"]
["V2 (up-regulated)","05/28/2009",19448619,"Stolk L","05/15/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19448619?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Loci at chromosomes 13, 19 and 20 influence age at natural menopause.","Menopause (age at onset)","2,979 women","2,560 women","13q34",13,112221297,"LOC121793, ARHGEF7",null,121793,6656,null,224.7,500.62,"rs7333181-A","rs7333181",0,7333181,null,1,0.12,3e-08,7.52287874528033,null,0.52,"[0.34-0.70] years older","Illumina [315,418]","N"]
["V2 (up-regulated)","05/19/2009",19430483,"Newton-Cheh C","05/10/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19430483?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association study identifies eight loci associated with blood pressure.","Diastolic blood pressure","34,433 individuals"," (up-regulated) to 100,347 white individuals,  (up-regulated) to 12,889 Indian Asian individuals","15q24.1",15,75077367,"CYP1A1, CYP1A2, CSK, LMAN1L, CPLX3, ARID3B","- ",null,null,1445,null,null,"rs1378942-C","rs1378942",0,1378942,"intron",0,0.36,1e-23,23,null,0.43,"[0.35-0.51] mm Hg increase","Affymetrix & Illumina [2,497,993] (imputed)","N"]
["V2 (up-regulated)","05/12/2009",19414484,"Johnson AD","05/04/2009","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19414484?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association meta-analysis for total serum bilirubin levels.","Bilirubin levels","9,264 individuals","NR","13q34",13,111818832,"ARHGEF7","- ",null,null,8874,null,null,"rs4773330-A","rs4773330",0,4773330,"intron",0,0.12,8e-06,5.09691001300805,null,0.04,"[0.02-0.06] umol/l decrease in log(tbil)","Affymetrix & Illumina [2,555,103] (imputed)","N"]
["V2 (up-regulated)","05/11/2009",19404256,"Wang K","04/28/2009","Nature","http://www.ncbi.nlm.nih.gov/pubmed/19404256?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Common genetic variants on 5p14.1 associate with autism spectrum disorders.","Autism","3,101 family members, 1,204 cases, 6,491 controls","1,390 family members, 108 cases, 540 controls","5p14.1",5,25967703,"CDH10,CDH9",null,4479,1007,null,54.32,913.01,"rs4307059-T","rs4307059",0,4307059,null,1,0.61,2e-10,9.69897000433601,null,1.19,"[NR] ","Illumina [474,019]","N"]
["V2 (up-regulated)","12/29/2009",20031577,"Danik JS","04/01/2009","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/20031577","Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.","Fibrinogen","17,686 European ancestry women","NR","5q31.1",5,131744574,"SLC22A5, SLC22A4, IRF1","- ",null,null,441108,null,null,"rs1016988-G","rs1016988",0,1016988,"nearGene-5",0,0.2,1e-12,12,null,6.84,"[NR] mg/dl decrease","Illumina [337,343]","N"]
["V2 (up-regulated)","12/29/2009",20031577,"Danik JS","04/01/2009","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/20031577","Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.","Fibrinogen","17,686 European ancestry women","NR","5q31.1",5,131671662,"SLC22A5, SLC22A4, IRF1","- ",null,null,"6583;553103",null,null,"rs10479002-C","rs10479002",1,12777,"cds-synon;intron",0,0.04,1e-06,5.99999999999999,null,9.51,"[NR] mg/dl increase","Illumina [337,343]","N"]
["V2 (up-regulated)","03/31/2009",19305408,"Newton-Cheh C","03/22/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19305408?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Common variants at ten loci influence QT interval duration in the QTGEN Study.","QT interval","13,685 individuals","15,854 individuals","1p36.31",1,6279370,"RNF207,NPHP4, CHDS, ACOT7, PLEKHG5, KLH21","- ",null,null,388591,null,null,"rs846111-C","rs846111",0,846111,"missense",0,0.28,1e-16,16,null,1.75,"[1.41-2.09] msec increase","Affymetrix and Illumina [ (up-regulated) to 2,543,686] (imputed)","N"]
["V2 (up-regulated)","03/31/2009",19305408,"Newton-Cheh C","03/22/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19305408?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Common variants at ten loci influence QT interval duration in the QTGEN Study.","QT interval","13,685 individuals","15,854 individuals","16p13.13",16,11691753,"LITAF,CLEC16A, SNN, ZC3H7A, TNFRSF17",null,9516,8303,null,10.43,70.54,"rs8049607-T","rs8049607",0,8049607,null,1,0.49,5e-15,14.3010299956639,null,1.23,"[0.88-1.57] msec increase","Affymetrix and Illumina [ (up-regulated) to 2,543,686] (imputed)","N"]
["V2 (up-regulated)","12/09/2008",18951430,"Anney RJ","10/24/2008","Am J Med Genet B Neuropsychiatr Genet","http://www.ncbi.nlm.nih.gov/pubmed/18951430?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.","Attention deficit hyperactivity disorder and conduct disorder","938 affected trios","NR","1q25.3",1,183852914,"RGL1, GLT25D2","- ",null,null,23179,null,null,"rs10797919-G","rs10797919",0,10797919,"intron",0,0.59,9e-06,5.04575749056067,null,"NR","NR","Perlegen[378,332]","N"]
["V2 (up-regulated)","12/01/2008",18940312,"Yuan X","10/10/2008","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/18940312","Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.","Liver enzyme levels","7,751 European ancestry individuals","4,704 European ancestry and Asian Indian individuals","1p36.12",1,21821757,"NBPF3, ALPL, RAP1GAP",null,84224,249,null,10.36,14.1,"rs1780324-T","rs1780324",0,1780324,null,1,0.43,7e-15,14.1549019599857,"(ALP)",0.03,"[0.023-0.039] U/L increase","Affymetrix and Illumina[ (up-regulated) to 496,032]","N"]
["V2 (up-regulated)","05/07/2009",18839057,"Lesch KP","10/07/2008","J Neural Transm","http://www.ncbi.nlm.nih.gov/pubmed/18839057?ordinalpos=16&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.","Attention deficit hyperactivity disorder","343 cases, 304 controls","NR","22q11.22",22,22307519,"PPM1F","- ",null,null,9647,null,null,"rs412050-?","rs412050",0,412050,"nearGene-5",0,"NR",6e-06,5.22184874961635,null,"NR","NR","Affymetrix [504,219](pooled)","N"]
["V2 (up-regulated)","11/25/2008",18820697,"Miyagawa T","09/28/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18820697","Variant between CPT1B and CHKB associated with susceptibility to narcolepsy.","Narcolepsy","222 Japanese ancestry cases,389 Japanese ancestry controls","748 cases,994 controls","22q13.33",22,51017353,"CPT1B","- ",null,null,"1120;1375;386593",null,null,"rs5770917-C","rs5770917",0,5770917,"nearGene-3;nearGene-5;intron",0,0.17,6e-08,7.22184874961635,null,1.63,"[1.37-1.95] ","Affymetrix[249,133]","N"]
["V2 (up-regulated)","11/25/2008",18464913,"Melzer D","05/09/2008","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/18464913?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association study identifies protein quantitative trait loci (pQTLs).","Protein quantitative trait loci","1,200 individuals","NR","9q22.2",9,92887231,"GADD45G,DIRAS2",null,157916,375601,null,42.21,91.28,"rs2081670-?","rs2081670",0,2081670,null,1,0.15,3e-06,5.52287874528033,"(MIP-1b)","NR","NR","Illumina[496,032]","N"]
["V2 (up-regulated)","11/25/2008",18464913,"Melzer D","05/09/2008","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/18464913?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association study identifies protein quantitative trait loci (pQTLs).","Protein quantitative trait loci","1,200 individuals","NR","6q11.1",6,62697746,"KHDRBS2","- ",null,null,202559,null,null,"rs6455128-?","rs6455128",0,6455128,"intron",0,0.19,3e-07,6.52287874528033,"(GOT (AST))","NR","NR","Illumina[496,032]","N"]
["V2 (up-regulated)","11/25/2008",18372903,"Zeggini E","03/30/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18372903?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.","Type 2 diabetes","4,549 cases,5,579 controls","24,194 cases,55,598 controls","1p12",1,120517959,"NOTCH2, ADAM30","- ",null,null,4853,null,null,"rs10923931-T","rs10923931",0,10923931,"intron",0,0.11,4e-08,7.39794000867203,null,1.13,"[1.08-1.17] ","Affymetrix and Illumina[2,202,892](imputed)","N"]
["V2 (up-regulated)","11/25/2008",18245381,"Uda M","02/05/2008","Proc Natl Acad Sci U S A","http://www.ncbi.nlm.nih.gov/pubmed/18245381?rdinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.","Fetal hemoglobin levels","4,305 individuals","521 individuals","2p16.1",2,60720246,"BCL11A","- ",null,null,53335,null,null,"rs11886868-T","rs11886868",0,11886868,"intron",0,0.8,7e-35,34.1549019599857,null,0.48,"[NR] s.d. decrease in HbF","Affymetrix [362,129]","N"]
["V2 (up-regulated)","11/25/2008",18239089,"Kong A","02/02/2008","Science","http://www.ncbi.nlm.nih.gov/pubmed/18239089?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Sequence variants in the RNF212 gene associate with genome-wide recombination rate.","Recombination rate (females)","1,702 women","1,663 women","4p16.3",4,1078187,"RNF212,SPON2","- ",null,null,285498,null,null,"rs1670533-C","rs1670533",0,1670533,"intron",0,"0.23 (men and women combined)",2e-12,11.698970004336,null,88.2,"[63.7-112.7] cM increase","Illumina[309,241]","N"]
["V2 (up-regulated)","11/25/2008",18239089,"Kong A","02/02/2008","Science","http://www.ncbi.nlm.nih.gov/pubmed/18239089?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Sequence variants in the RNF212 gene associate with genome-wide recombination rate.","Recombination rate (males)","1,887 men","1,248 men","4p16.3",4,1095281,"RNF212,SPON2","- ",null,null,285498,null,null,"rs3796619-T","rs3796619",0,3796619,"intron",0,"0.33 (men and women combined)",3e-24,23.5228787452803,null,70.7,"[57.1-84.3] cM  decrease","Illumina [309,241]","N"]
["V2 (up-regulated)","11/25/2008",17903296,"Kiel DP","09/19/2007","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/17903296?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genome-wide association with bone mass and geometry in the Framingham Heart Study.","Hip geometry","1,141 individuals(Framingham)","NR","12p13.31",12,6580582,"VAMP1",null,6843,82500,null,0.74,6.22,"rs10492096-?","rs10492096",0,10492096,null,1,"NR",3e-06,5.52287874528033,"(ShaftZ1rf)","NR","NR","Affymetrix[70,897]","N"]
["V2 (up-regulated)","11/25/2008",17767159,"Menzel S","09/02/2007","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/17767159?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.","F-cell distribution","179 adults in  (up-regulated)per and lower 5%","90 adults","2p16.1",2,60718043,"BCL11A","- ",null,null,53335,null,null,"rs1427407-?","rs1427407",0,1427407,"intron",0,0.14,6e-31,30.2218487496163,null,13.1,"[NR] % of variance explained","Illumina [308,015]","N"]
["V2 (down-regulated)","06/26/2013",23535033,"Sherva R","03/24/2013","Alzheimers Dement","http://www.ncbi.nlm.nih.gov/pubmed/23535033","Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.","Alzheimer's disease (cognitive decline)","303 European ancestry cases",null,"5q21.3",5,109221026,"PGAM5P1,MAN2A1","- ",null,null,100289673,null,null,"rs112724034-?","rs112724034",0,112724034,"ncRNA",0,0.03,9e-13,12.0457574905606,null,0.31,"unit decrease","Illumina [NR] (Imputed)","N"]
["V2 (down-regulated)","06/26/2013",23535033,"Sherva R","03/24/2013","Alzheimers Dement","http://www.ncbi.nlm.nih.gov/pubmed/23535033","Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.","Alzheimer's disease (cognitive decline)","303 European ancestry cases",null,"5q23.1",5,118435127,"DMXL1","- ",null,null,1657,null,null,"rs116348108-?","rs116348108",0,116348108,"intron",0,0.04,9e-07,6.04575749056067,null,0.28,"unit decrease","Illumina [NR] (Imputed)","N"]
["V2 (down-regulated)","06/20/2013",23496005,"Luca G","03/18/2013","J Sleep Res","http://www.ncbi.nlm.nih.gov/pubmed/23496005","Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study.","Narcolepsy with cataplexy","585 European ancestry cases","387 European ancestry cases","8q12.1",8,59324162,"UBXN2B","- ",null,null,137886,null,null,"rs2859998-?","rs2859998",0,2859998,"intron",0,"NR",1e-07,7,"(Age EDS onset)",4.41,"[NR] unit decrease","NR","N"]
["V2 (down-regulated)","05/26/2013",23509613,"Kamboh MI","02/24/2013","Autoimmune Dis","http://www.ncbi.nlm.nih.gov/pubmed/23509613","Genome-wide association study of antiphospholipid antibodies.","Presence of antiphospholipid antibodies","183 European ancestry ACL-positive cases, 487 European ancestry ACL-negative controls, 127 European ancestry LAC-positive cases, 581 European ancestry LAC-negative controls, 136 European ancestry Anti-B2GPI-positive cases, 360 European ancestry Anti-B2GPI-negative controls","NR","20p12.1",20,17566069,"DSTN","- ",null,null,11034,null,null,"rs17791782-?","rs17791782",0,17791782,"intron",0,0.07867,6e-06,5.22184874961635,"(LAC)",2.63,"[NR] ","Affymetrix [906,600]","N"]
["V2 (down-regulated)","06/06/2013",23419831,"Ramanan VK","02/19/2013","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23419831","APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.","Alzheimer's disease biomarkers","555 European ancestry individuals","NR","NR",null,null,"ITGA6","- ",{"$nulls":5},"Position 173336636-A","Position 173336636",{"$nulls":4},0.43,6e-07,null,"(Cortical Ab)","NR","NR","Illumina [6,108,668] (imputed)","N"]
["V2 (down-regulated)","05/11/2013",23400010,"Del-Aguila JL","02/12/2013","Pharmacogenomics J","http://www.ncbi.nlm.nih.gov/pubmed/23400010","Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.","Thiazide-induced adverse metabolic effects in hypertensive patients","425 European ancestry cases, 342 African American cases","NR","10q24.31",10,102256197,"ERLIN1","- ",null,null,25956,null,null,"rs9420790-A","rs9420790",0,9420790,"intron",0,0.08,2e-06,5.69897000433601,"(AA-triglyceride response)",34.63,"[20.46-48.8] mg/dL decrease","Illumina and Affymetrics [>2 million] (Imputed)","N"]
["V2 (down-regulated)","05/09/2013",23377640,"GENDEP Investigators","02/01/2013","Am J Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23377640 ","Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.","Major depressive disorder"," (up-regulated) to 2,256 European ancestry cases","NR","15q23",15,68597127,"PIAS1,CALML4,CLN6,FEM1B,ITGA11","- ",null,null,22801,null,null,"rs7174755-C","rs7174755",0,7174755,"intron",0,0.3690476,3e-07,6.52287874528033,"(% improvement - SSRI treated - 2 weeks)",0.2,"[0.13-0.28] unit decrease","Illumina & Affymetrix [1.2 million] (Imputed)","N"]
["V2 (down-regulated)","03/22/2013",23303382,"Hong KW","01/10/2013","J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23303382 ","Genome-wide association study of serum albumin:globulin ratio in Korean populations.","Hematology traits","4,637 East Asian ancestry individuals","4,205 East Asian ancestry individuals","1q42.13",1,230388989,"GALNT2","- ",null,null,2590,null,null,"rs3761944-C","rs3761944",0,3761944,"intron",0,0.224,8e-06,5.09691001300805,"(ALB/GLB)",0.02,"[0.0082-0.0238] unit increase","Affymetrix [290,659]","N"]
["V2 (down-regulated)","03/28/2013",23291589,"Lu Y","01/06/2013","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23291589 ","Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.","Corneal structure","13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals","NR","9p23",9,13557491,"MPDZ, NF1B",null,401492,347193,null,126.16,428.63,"rs1324183-A","rs1324183",0,1324183,null,1,0.2,8e-09,8.09691001300805,null,0.05,"[0.011-0.089] unit decrease","Illumina & Affymetrix [~1 Million] (Imputed)","N"]
["V2 (down-regulated)","02/27/2013",23284291,"Hancock DB","12/20/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23284291 ","Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.","Pulmonary function (interaction)","50,047 European ancestry individuals","NR","2p24.3",2,15926168,"DDX1 ,  MYCN ",null,1653,130678,null,154.93,83.77,"rs2544527-T ","rs2544527   ",0,2544527,null,1,"NR",2e-07,6.69897000433601,"(FEV1/FVC, Pack-years)","NR","NR","NR [~2.5 Million] (imputed)","N"]
["V2 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","12q21.2",12,76476956,"NAP1L1","- ",null,null,4673,null,null,"rs1368578-A","rs1368578",0,1368578,"intron",0,0.072,1e-06,5.99999999999999,"(HRmax )",0.04,"[NR]  bpm increase","Illumina [899,892]","N"]
["V2 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","2q24.1",2,155002847,"GALNT13","- ",null,null,114805,null,null,"rs16836124-G","rs16836124",0,16836124,"intron",0,0.054,6e-06,5.22184874961635,"(ALT/AST)",0.03,"[NR]  unit increase","Illumina [899,892]","N"]
["V2 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","3q24",3,145888457,"PLOD2",null,5352,57088,null,9.18,21.67,"rs1913185-C","rs1913185",0,1913185,null,1,0.249,2e-07,6.69897000433601,"(NEFA )",0.04,"[NR]  mmol/L increase","Illumina [899,892]","N"]
["V2 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","1q42.3",1,235267127,"TOMM20",null,100431173,9804,null,293.31,5.53,"rs11577354-G","rs11577354",0,11577354,null,1,0.445,7e-06,5.15490195998574,"(RQmax)",0.04,"[NR]   increase","Illumina [899,892]","N"]
["V2 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","3q13.33",3,120425331,"RABL3, GTF2E1","- ",null,null,285282,null,null,"rs13077101-G","rs13077101",0,13077101,"intron",0,0.177,2e-07,6.69897000433601,"(AST/ALT)",0.03,"[NR]  unit increase","Illumina [899,892]","N"]
["V2 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","3q13.33",3,120425331,"GTF2E1, RABL3","- ",null,null,285282,null,null,"rs13077101-G","rs13077101",0,13077101,"intron",0,0.177,1e-06,5.99999999999999,"(ALT/AST)",0.03,"[NR]  unit increase","Illumina [899,892]","N"]
["V2 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","6p24.1",6,12510127,"RPL15P3",null,1906,653232,null,212.7,4.18,"rs12198798-G","rs12198798",0,12198798,null,1,0.114,1e-06,5.99999999999999,"(BMI z-score change )",0.04,"[NR]  SD/y increase","Illumina [899,892]","N"]
["V2 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","15q26.1",15,89617081,"ABHD2",null,390634,692147,null,112.74,61.22,"rs420017-A","rs420017",0,420017,null,1,0.336,8e-06,5.09691001300805,"(BMR )",0.04,"[NR]  kcal/d increase","Illumina [899,892]","N"]
["V2 (down-regulated)","02/14/2013",23192594,"Velez Edwards DR","11/29/2012","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23192594 ","Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.","Waist-to-hip circumference ratio (interaction)","8,203 African American women, 3,484 Hispanic ancestry women","NR","2q32.1",2,183685562,"DNAJC10, FRZB",null,100270984,2487,null,32.4,12.44,"rs10931041-A","rs10931041",0,10931041,null,1,"NR",9e-06,5.04575749056067,"(Dietary energy)",0.02,"[NR] unit decrease","Affymetrix [706,791]","N"]
["V2 (down-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","20q13.32",20,57824309,"ZNF831,CTSZ","- ",null,null,128611,null,null,"rs259964-A","rs259964",0,259964,"intron",0,0.464,1e-12,12,null,1.09,"[1.054-1.116] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V2 (down-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Ulcerative colitis"," (up-regulated) to 12,924 European ancestry cases,  (up-regulated) to 21,442 European ancestry controls"," (up-regulated) to 25,683 European ancestry cases,  (up-regulated) to 17,015 European ancestry controls","3p21.1",3,53062661,"PRKCD,ITIH4","- ",null,null,"51460;401068",null,null,"rs9847710-C","rs9847710",0,9847710,"intron;intron",0,0.416,1e-08,8,null,1.06,"[1.027-1.102] ","Affymetrix & Illumina [1.23 million] (imputed)","N"]
["V2 (down-regulated)","11/21/2012",22916037,"Inouye M","08/16/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22916037","Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.","Metabolite levels","6,608 European ancestry individuals","NR","8p23.1",8,9183596,"PPP1R3B, TNKS","- ",null,null,157273,null,null,"rs4841132-?","rs4841132",0,4841132,"ncRNA",0,0.15,2e-09,8.69897000433601,null,"NR","NR","Illumina [~2 million] (imputed)","N"]
["V2 (down-regulated)","11/21/2012",22916037,"Inouye M","08/16/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22916037","Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.","Metabolite levels","6,608 European ancestry individuals","NR","1q42.13",1,230295789,"GALNT2","- ",null,null,2590,null,null,"rs10127775-?","rs10127775",0,10127775,"intron",0,0.44,1e-09,8.99999999999999,null,"NR","NR","Illumina [~2 million] (imputed)","N"]
["V2 (down-regulated)","09/26/2012",22837378,"Wilk JB","07/26/2012","Am J Respir Crit Care Med","http://www.ncbi.nlm.nih.gov/pubmed/22837378","Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.","Airflow obstruction "," (up-regulated) to 3,368 European ancestry cases,  (up-regulated) to 29,507 European ancestry controls","331 European ancestry cases, 2,550 European ancestry controls","4q12",4,57334112,"SRP72","- ",null,null,6731,null,null,"rs12505749-?","rs12505749",0,12505749,"intron",0,0.08,5e-06,5.30102999566398,"(All)",1.27,null,"Affymetrix & Illumina [ (up-regulated) to ~2,500,000] (imputed)","N"]
["V2 (down-regulated)","09/26/2012",22837378,"Wilk JB","07/26/2012","Am J Respir Crit Care Med","http://www.ncbi.nlm.nih.gov/pubmed/22837378","Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.","Airflow obstruction "," (up-regulated) to 3,368 European ancestry cases,  (up-regulated) to 29,507 European ancestry controls","331 European ancestry cases, 2,550 European ancestry controls","17q25.3",17,75400100,41526,"- ",null,null,10801,null,null,"rs892961-?","rs892961",0,892961,"intron",0,0.59,9e-06,5.04575749056067,"(no asthma)",1.18,null,"Affymetrix & Illumina [ (up-regulated) to ~2,500,000] (imputed)","N"]
["V2 (down-regulated)","09/20/2012",22823124,"Verweij KJ","07/24/2012","Addict Biol","http://www.ncbi.nlm.nih.gov/pubmed/22823124","The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.","Cannbis use (initiation)","10,091 individuals from 4,622 families","NR","6q25.3",6,158389741,"SYNJ2",null,51429,8871,null,23.63,13.15,"rs9458975-T","rs9458975",0,9458975,null,1,0.45,7e-06,5.15490195998574,null,0.03,"unit increase","Illumina [~2.4 million] (imputed)","N"]
["V2 (down-regulated)","09/12/2012",22763476,"Zhang D","07/05/2012","Hypertens Res","http://www.ncbi.nlm.nih.gov/pubmed/22763476","Genome-wide linkage and association scans for pulse pressure in Chinese twins.","Blood pressure","63 Chinese ancestry dizygotic twin pairs","NR","1q31.2",1,192431998,"RGS21, PPP3CA",null,431704,5996,null,95.58,112.86,"rs12067906-?","rs12067906",0,12067906,null,1,"NR",9e-07,6.04575749056067,null,"NR","NR","Affymetrix [~900,000]","N"]
["V2 (down-regulated)","09/12/2012",22763476,"Zhang D","07/05/2012","Hypertens Res","http://www.ncbi.nlm.nih.gov/pubmed/22763476","Genome-wide linkage and association scans for pulse pressure in Chinese twins.","Blood pressure","63 Chinese ancestry dizygotic twin pairs","NR","4q24",4,102560290,"BANK1, PPP3CA",null,90024,55024,null,290.25,151.47,"rs17031508-?","rs17031508",0,17031508,null,1,"NR",8e-08,7.09691001300805,null,"NR","NR","Affymetrix [~900,000]","N"]
["V2 (down-regulated)","08/20/2012",22747683,"Eriksson N","06/30/2012","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/22747683","Genetic variants associated with breast size also influence breast cancer risk.","Breast size","16,175 European ancestry women","NR","3q22.1",null,null,"TMCC1","- ",{"$nulls":5},"chr3:130947635-A","chr3:130947635",{"$nulls":4},0.001,5e-07,null,null,2.3,"[1.41-3.19] c (up-regulated) size increase","Illumina [7,422,970] (imputed)","N"]
["V2 (down-regulated)","08/14/2012",22685421,"Fan Q","06/07/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22685421","Genetic variants on chromosome 1q41 influence ocular axial length and high myopia.","Myopia (pathological)","2,789 Singaporean Chinese ancestry individuals, 2,155 Singaporean Malay ancestry individuals","NR","2p16.2",2,54718181,"SPTBN1","- ",null,null,6711,null,null,"rs4557020-T","rs4557020",0,4557020,"intron",0,0.37,3e-07,6.52287874528033,null,0.12,"[0.081-0.159] mm decrease","Illumina [456,634]","N"]
["V2 (down-regulated)","07/17/2012",22658654,"Chung SJ","05/30/2012","Parkinsonism Relat Disord","http://www.ncbi.nlm.nih.gov/pubmed/22658654","Genomic determinants of motor and cognitive outcomes in Parkinson's disease.","Parkinson's disease (motor and cognition)","443 European ancestry cases","NR","5q23.2",5,126181862,"LMNB1",null,4001,115123,null,9.15,21.54,"rs959573-?","rs959573",0,959573,null,1,"NR",5e-06,5.30102999566398,"(cognitive outcome)",1.92,"[1.49-2.50] ","NR [198,345]","N"]
["V2 (down-regulated)","08/07/2012",22610502,"Kennedy RB","05/19/2012","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/22610502","Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.","Immune reponse to smallpox (secreted IL-2)"," (up-regulated) to 512 European ancestry individuals,  (up-regulated) to 199 African American individuals","NR","1q42.3",1,235092600,"TOMM20",null,100431173,9804,null,118.78,180.06,"rs908327-C","rs908327",0,908327,null,1,"NR",5e-10,9.30102999566398,"(AA)","NR","NR","Illumina [NR]","N"]
["V2 (down-regulated)","08/14/2012",22566634,"Benjamin DJ","05/07/2012","Proc Natl Acad Sci U S A","http://www.ncbi.nlm.nih.gov/pubmed/22566634","The genetic architecture of economic and political preferences.","Economic and political preferences","9,617 individuals","NR","8p22",8,17800769,"PCM1","- ",null,null,5108,null,null,"rs2299587-T","rs2299587",0,2299587,"intron",0,"NR",9e-07,6.04575749056067,"(Trust)",0.13,"[0.074-0.176] unit decrease","Illumina [628,922]","N"]
["V2 (down-regulated)","07/13/2012",22544364,"Turnbull C","04/29/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22544364","A genome-wide association study identifies susceptibility loci for Wilms tumor.","Wilms tumor","757 European ancestry cases, 1,879 European ancestry controls","1,488 European ancestry cases, 3,851 European ancestry controls","2p24.3",2,15782471,"DDX1, MYCN",null,1653,130678,null,11.24,227.46,"rs807624-A","rs807624",0,807624,null,1,0.35,1e-14,14,null,1.33,"[1.22-1.45] ","Illumina [599,255]","N"]
["V2 (down-regulated)","07/13/2012",22544364,"Turnbull C","04/29/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22544364","A genome-wide association study identifies susceptibility loci for Wilms tumor.","Wilms tumor","757 European ancestry cases, 1,879 European ancestry controls","1,488 European ancestry cases, 3,851 European ancestry controls","2p24.3",2,15729820,"DDX1, MYCN","- ",null,null,1653,null,null,"rs3755132-G","rs3755132",0,3755132,"nearGene-5",0,0.14,1e-14,14,null,1.45,"[1.29-1.64] ","Illumina [599,255]","N"]
["V2 (down-regulated)","04/11/2013",22504420,"Estrada K","04/15/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22504420","Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.","Bone mineral density"," (up-regulated) to 32,961 European and East Asian ancestry individuals"," (up-regulated) to 50,933 European and East Asian ancestry individuals","9q34.11",9,133478827,"FUBP3","- ",null,null,8939,null,null,"rs7851693-C","rs7851693",0,7851693,"intron",0,0.64,3e-22,21.5228787452803,"(FNBMD)",0.05,"[NR] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V2 (down-regulated)","04/11/2013",22504420,"Estrada K","04/15/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22504420","Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.","Bone mineral density"," (up-regulated) to 32,961 European and East Asian ancestry individuals"," (up-regulated) to 50,933 European and East Asian ancestry individuals","2p16.2",2,54659707,"SPTBN1",null,129852,56969,null,70.99,96.65,"rs4233949-C","rs4233949",0,4233949,null,1,0.38,2e-18,17.698970004336,"(LSBMD)",0.05,"[NR] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V2 (down-regulated)","05/24/2012",22479191,"Pattaro C","03/29/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22479191","Genome-wide association and functional follow- (up-regulated) reveals new loci for kidney function.","Chronic kidney disease","74,354  European ancestry individuals","56,246 European ancestry individuals","2p24.3",2,15863002,"DDX1",null,1653,130678,null,91.77,146.93,"rs6431731-?","rs6431731",0,6431731,null,1,"NR",4e-08,7.39794000867203,null,0.01,"[0.0082-0.0172] ml/min/1.73m^2 decrease","Affymetrix & Illumina [~2.5 million} (imputed)","N"]
["V2 (down-regulated)","04/25/2012",22446961,"Lee YC","03/25/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22446961","Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis.","Kawasaki disease","622 Taiwanese Han Chinese cases, 1,107 Taiwanese Han Chinese controls","261 Taiwanese Han Chinese cases, 550 Taiwanese Han Chinese controls","3q23",3,139043236,"COPB2",null,140464,56945,null,90.87,19.63,"rs4894410-G","rs4894410",0,4894410,null,1,0.021,8e-06,5.09691001300805,null,2.09,"[1.498-2.925] ","Affymetrix [716,935]","N"]
["V2 (down-regulated)","04/18/2012",22446040,"Wang KS","03/16/2012","Gene","http://www.ncbi.nlm.nih.gov/pubmed/22446040","A novel locus for body mass index on 5p15.2: a meta-analysis of two genome-wide association studies.","Body mass index","5,218 European ancestry individuals","762 European ancestry individuals","5p15.2",5,10372618,41339,"- ",null,null,10299,null,null,"rs2607292-T","rs2607292",0,2607292,"intron",0,0.1,4e-06,5.39794000867203,null,0.77,"[NR] unit increase","Illumina [ (up-regulated) to 520,531]","N"]
["V2 (down-regulated)","04/03/2012",22412388,"Kenny EE","03/08/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22412388","A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.","Crohn's disease","737 Ashkenazi Jewish cases, 2,257  Ashkenazi Jewish controls","971 Ashkenazi Jewish cases, 2,124 Ashkenazi Jewish controls","8q21.11",8,74007347,"C8orf84, TERF1, RPL7, RDH10, KCNB2","- ",null,null,157869,null,null,"rs12677663-T","rs12677663",0,12677663,"nearGene-5",0,0.659,2e-08,7.69897000433601,null,1.15,"[1.04-1.28] ","Affyemtrix & Illumina [1,060,934] (imputed)","N"]
["V2 (down-regulated)","04/03/2012",22412388,"Kenny EE","03/08/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22412388","A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.","Crohn's disease","737 Ashkenazi Jewish cases, 2,257  Ashkenazi Jewish controls","971 Ashkenazi Jewish cases, 2,124 Ashkenazi Jewish controls","2p16.1",2,61186829,"PUS10, PEX13, REL, KIAA1841, C2orf74, PAPOLG, USP34","- ",null,null,150962,null,null,"rs13003464-G","rs13003464",0,13003464,"intron",0,0.487,5e-09,8.30102999566398,null,1.05,"[1.00-1.40] ","Affyemtrix & Illumina [1,060,934] (imputed)","N"]
["V2 (down-regulated)","04/03/2012",22412388,"Kenny EE","03/08/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22412388","A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.","Crohn's disease","737 Ashkenazi Jewish cases, 2,257  Ashkenazi Jewish controls","971 Ashkenazi Jewish cases, 2,124 Ashkenazi Jewish controls","1p31.3",1,67705958,"IL23R, IL12RB2, C1orf141, SERBP1,SLC35D1","- ",null,null,149233,null,null,"rs11209026-G","rs11209026",0,11209026,"missense",0,0.921,1e-18,18,null,2.2,"[2.10-2.35] ","Affyemtrix & Illumina [1,060,934] (imputed)","N"]
["V2 (down-regulated)","04/03/2012",22399527,"Kristiansson K","03/07/2012","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/22399527","Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.","Metabolic syndrome","2,637 European ancestry cases, 7,927 European ancestry controls","NR","1q42.13",1,230307182,"GALNT2","- ",null,null,2590,null,null,"rs4846922-T","rs4846922",0,4846922,"intron",0,0.39,4e-08,7.39794000867203,"(HDL)",0.08,"[NR] mmol/l decrease","Illumina [1,257,079] (imputed)","N"]
["V2 (down-regulated)","04/25/2012",22443383,"Oudot-Mellakh T","01/16/2012","Br J Haematol","http://www.ncbi.nlm.nih.gov/pubmed/22443383","Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project.","Hemostatic factors and hematological phenotypes","951 European ancestry individuals","NR","4p16.3",4,735150,"PCGF3","- ",null,null,10336,null,null,"rs4234853-A","rs4234853",0,4234853,"intron",0,0.27,6e-06,5.22184874961635,"(PS levels)",4.88,"[2.76-7.00] iu/ml decrease","Illumina [472,123]","N"]
["V2 (down-regulated)","01/17/2012",22190364,"Patsopoulos NA","12/01/2011","Ann Neurol","http://www.ncbi.nlm.nih.gov/pubmed/22190364","Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.","Multiple sclerosis","5,545 European ancestry cases, 12,153 European ancestry controls","NR","17q21.32",17,45768836,"KPNB1, TBKBP1, TBX21",null,3837,9755,null,7.83,3.79,"rs8070463-T","rs8070463",0,8070463,null,1,0.5,1e-07,7,null,1.15,"[NR] ","Affymetrix & Illumina [2,529,394]","N"]
["V2 (down-regulated)","11/16/2012",22139419,"Gieger C","11/30/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/22139419","New gene functions in megakaryopoiesis and platelet formation.","Mean platelet volume","18,600 European ancestry individuals"," (up-regulated) to 18,838 European ancestry individuals","20q13.32",20,57587771,"CTSZ,TUBB1",null,1522,81027,null,5.46,6.54,"rs4812048-C","rs4812048",0,4812048,null,1,"NR",1e-09,8.99999999999999,null,0.01,"[0.006-0.01] ln(fl) increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V2 (down-regulated)","11/16/2012",22139419,"Gieger C","11/30/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/22139419","New gene functions in megakaryopoiesis and platelet formation.","Mean platelet volume","18,600 European ancestry individuals"," (up-regulated) to 18,838 European ancestry individuals","12q13.13",12,54712308,"COPZ1,NFE2,CBX5",null,4778,442892,null,17.49,18.69,"rs10876550-G","rs10876550",0,10876550,null,1,"NR",2e-14,13.698970004336,null,0.01,"[0.006-0.01] ln(fl) increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V2 (down-regulated)","11/16/2012",22139419,"Gieger C","11/30/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/22139419","New gene functions in megakaryopoiesis and platelet formation.","Platelet counts","48,666 individuals of European ancestry"," (up-regulated) to 18,838 individuals of European ancestry","9q34.2",9,136925663,"BRD3","- ",null,null,8019,null,null,"rs11789898-T","rs11789898",0,11789898,"intron",0,"NR",2e-10,9.69897000433601,null,3.01,"[2.08-3.95] 10^9/l increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V2 (down-regulated)","12/14/2011",22087292,"Sun L","11/07/2011","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/22087292","Bivariate genome-wide association analyses of femoral neck bone geometry and appendicular lean mass.","Femoral neck bone geometry","1,627 Han Chinese individuals","2,286 European ancestry individuals","2p12",2,75074967,"HK2","- ",null,null,3099,null,null,"rs681900-?","rs681900",0,681900,"intron",0,"NR",3e-06,5.52287874528033,"(ALM-BR)","NR","NR","Affymetrix [689,368]","N"]
["V2 (down-regulated)","11/25/2011",22021425,"Carty CL","10/21/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/22021425","Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe).","Height","8,149 African American ancestry women"," (up-regulated) to 20,809 African American ancestry and African ancestry individuals","17q24.2",17,64779430,"PRKCA","- ",null,null,5578,null,null,"rs3889237-C","rs3889237",0,3889237,"intron",0,0.14,3e-08,7.52287874528033,null,0.06,"[0.029-0.083] unit decrease","Affymetrix [855,034]","N"]
["V2 (down-regulated)","11/04/2011",21979947,"Li X","10/06/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21979947","A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries.","Corneal structure","222 European ancestry cases, 3,324 European ancestry controls","304 European ancestry cases, 518 European ancestry controls, 146 European ancestry cases from 70 families, 161 European ancestry controls from 70 families","4q24",4,102037719,"PPP3CA","- ",null,null,5530,null,null,"rs2659546-?","rs2659546",0,2659546,"intron",0,"NR",4e-06,5.39794000867203,null,1.63,null,"Illumina [~290,000]","N"]
["V2 (down-regulated)","10/26/2011",21980299,"Bradfield JP","09/29/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21980299","A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.","Type 1 diabetes","9,934 European ancestry cases, 16,956 European ancestry controls","1,120 European ancestry affected trios","6q27",6,170379025,"WDR27, C6orf120, PHF10, TCTE3, C6orf208, LOC154449, DLL1, FAM120B, PSMB1, TBP, PCD2",null,80069,100270925,null,176.06,135.99,"rs924043-?","rs924043",0,924043,null,1,0.85,8e-09,8.09691001300805,null,1.35,"[NR] ","Affymetrix & Illumina [~2.54 million] (imputed)","N"]
["V2 (down-regulated)","10/16/2011",21946350,"Soler Artigas M","09/25/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21946350","Genome-wide association and large-scale follow  (up-regulated) identifies 16 new loci influencing lung function.","Pulmonary function","48,201 European ancestry individuals","46,411 European ancestry individuals","2p24.3",2,15926168,"DDX1",null,1653,130678,null,154.93,83.77,"rs2544527-T","rs2544527",0,2544527,null,1,"NR",9e-06,5.04575749056067,"(FEV1/FVC)",0.03,"[0.014-0.038] unit decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V2 (down-regulated)","10/19/2011",21926972,"Sklar P","09/18/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21926972","Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.","Bipolar disorder","7,481 European ancestry cases, 9,250 European ancestry controls","4,496 European ancestry cases, 42,422 European ancestry controls","3p21.1",3,52835354,"WDR82, TWF2, TNNC1, TMEM110, TLR9, STAB1,SPCS1, SNORD69, SNORD19, SNORD19B, SFMBT1, SEMA3G, RFT1, PRKCD, PPM1M, PHF7, PBRM1, NT5DC2, NISCH, NEK4, MUSTN1, LOC440957, ITIH1, ITIH3, ITIH4, GNL3, GLYCTK, GLT8D1, DNAH1, BAP1, ALAS1","- ",null,null,3699,null,null,"rs736408-C","rs736408",0,736408,"intron",0,"NR",2e-06,5.69897000433601,null,1.1,"[NR] ","Affymetrix & Illumina [2,415,422] (imputed)","N"]
["V2 (down-regulated)","10/19/2011",21926972,"Sklar P","09/18/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21926972","Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.","Bipolar disorder","7,481 European ancestry cases, 9,250 European ancestry controls","4,496 European ancestry cases, 42,422 European ancestry controls","2q11.2",2,99382892,"TXNDC9, TSGA10, REV1, MRPL30, MITD1, MGAT4A, LYG1, LYG2, LIPT1, EIF5B, C2orf55, C2orf15",null,100130391,343990,null,70.94,27.42,"rs7578035-G","rs7578035",0,7578035,null,1,"NR",3e-06,5.52287874528033,null,1.09,"[NR] ","Affymetrix & Illumina [2,415,422] (imputed)","N"]
["V2 (down-regulated)","03/03/2012",21732829,"Dolmans GH","07/06/2011","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/21732829","Wnt signaling and D (up-regulated)uytren's disease.","D (up-regulated)uytren's disease","856 European ancestry cases, 2,836 European ancestry controls","1,298 European ancestry cases, 7,136 European ancestry controls","8q23.1",8,109228008,"EIF3E, RSPO2","- ",null,null,3646,null,null,"rs611744-?","rs611744",0,611744,"intron",0,0.6,8e-15,14.096910013008,null,1.33,"[1.23-1.43] ","Illumina [234,939]","N"]
["V2 (down-regulated)","07/20/2011",21738487,"Do CB","06/23/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21738487","Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.","Parkinson's disease","3,426 cases, 29,624 controls","NR","4q21.1",4,77198986,"SCARB2","- ",null,null,"100129583;100631383",null,null,"rs6812193-C","rs6812193",0,6812193,"intron;intron",0,0.64,8e-10,9.09691001300805,null,1.19,"[1.12-1.27] ","Illumina [522,782]","N"]
["V2 (down-regulated)","07/14/2011",21685187,"Siedlinski M","06/16/2011","Thorax","http://www.ncbi.nlm.nih.gov/pubmed/21685187","Genome-wide association study of smoking behaviours in patients with COPD.","Chronic obstructive pulmonary disease","3,441 Caucasian ever-smokers with COPD","NR","NR",null,null,"MSH6","- ",{"$nulls":5},"rs77155169-T","rs77155169",{"$nulls":4},0.06,2e-07,6.69897000433601,"(Lifetime average CPD)",4.67,"[NR] ","Illumina [~6.3 million] (imputed)","N"]
["V2 (down-regulated)","06/01/2011",21507922,"Ramsuran V","05/01/2011","Clin Infect Dis","http://www.ncbi.nlm.nih.gov/pubmed/21507922","Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.","Neutrophil count","115 African ancestry HIV-negative individuals","NR","2p25.1",2,8949070,"KIDINS220","- ",null,null,57498,null,null,"rs7587928-?","rs7587928",0,7587928,"intron",0,"NR",2e-07,6.69897000433601,null,"NR","NR","Illumina [874,956]","N"]
["V2 (down-regulated)","04/11/2011",21378990,"Schunkert H","03/06/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21378990","Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.","Coronary heart disease","22,233 European ancestry cases, 64,762 European ancestry controls","28,834 cases, 27,674 controls, 2,115 individuals.","1q41",1,222823529,"MIA3","- ",null,null,375056,null,null,"rs17465637-C","rs17465637",0,17465637,"intron",0,0.74,1e-08,8,null,1.14,"[1.09-1.20] ","Affymetrix & Illumina {~2.3 million] (imputed)","N"]
["V2 (down-regulated)","04/05/2011",21323541,"Stanescu HC","02/22/2011","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/21323541","Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.","Nephropathy (idiopathic membranous)","556 European ancestry cases, 2,338 European ancestry controls","NR","2q24.2",2,160917497,"PLA2R1,LY75,ITGB6,RBMS1","- ",null,null,22925,null,null,"rs4664308-?","rs4664308",0,4664308,"intron",0,0.43,9e-29,28.0457574905606,null,2.28,"[1.96-2.64] ","Illumina [242,824]","N"]
["V2 (down-regulated)","01/12/2011",21116278,"Furney SJ","11/30/2010","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/21116278","Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.","Total ventricular volume"," (up-regulated) to 434 Caucasian MCI cases, 236 Caucasian AD cases, 284 Caucasian controls","NR","3q29",3,196553867,"PAK2","- ",null,null,5062,null,null,"rs2084385-?","rs2084385",0,2084385,"intron",0,"NR",5e-06,5.30102999566398,null,0.01,"[NR] unit increase (interaction)","Illumina [488,911]","N"]
["V2 (down-regulated)","01/06/2011",21076409,"Sotoodehnia N","11/14/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21076409","Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.","Ventricular conduction","40,407 European ancestry individuals","7,170 European ancestry individuals","3p21.1",3,53282303,"TKT, PRKCD, CACNA1D","- ",null,null,7086,null,null,"rs4687718-A","rs4687718",0,4687718,"intron",0,0.14,6e-09,8.22184874961635,null,0.63,"[0.41-0.85] ms decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V2 (down-regulated)","01/06/2011",21076409,"Sotoodehnia N","11/14/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21076409","Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.","Ventricular conduction","40,407 European ancestry individuals","7,170 European ancestry individuals","17q24.2",17,64318357,"PRKCA","- ",null,null,5578,null,null,"rs9912468-G","rs9912468",0,9912468,"intron",0,0.43,1e-08,8,null,0.39,"[0.25-0.53] ms increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V2 (down-regulated)","12/03/2010",20966902,"Croteau-Chonka DC","10/21/2010","Obesity (Silver Spring)","http://www.ncbi.nlm.nih.gov/pubmed/20966902","Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.","Body mass index","1,792 Filipino women","NR","17q25.3",17,75701697,41526,null,100422851,400624,null,308.56,173.39,"rs9906155-T","rs9906155",0,9906155,null,1,0.91,9e-06,5.04575749056067,null,0.05,"[0.02-0.07] unit increase","Affymetrix [2,073,674] (imputed)","N"]
["V2 (down-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","6q14.1",6,76265642,"SENP6",null,100271191,26054,null,55.78,45.98,"rs9360921-T","rs9360921",0,9360921,null,1,0.89,3e-13,12.5228787452803,null,0.04,"[NR] unit decrease","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V2 (down-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","9q34.11",9,133464084,"FUBP3","- ",null,null,8939,null,null,"rs7466269-A","rs7466269",0,7466269,"intron",0,0.64,3e-17,16.5228787452803,null,0.03,"[NR] unit increase","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V2 (down-regulated)","10/17/2010",20864672,"Waterworth DM","09/23/2010","Arterioscler Thromb Vasc Biol","http://www.ncbi.nlm.nih.gov/pubmed/20864672","Genetic variants influencing circulating lipid levels and risk of coronary artery disease.","HDL cholesterol"," (up-regulated) to 17,243 white European descent individuals"," (up-regulated) to 37,774 white European descent individuals,  (up-regulated) to 9,665 Indian Asian individuals","1q42.13",1,230304988,"GALNT2","- ",null,null,2590,null,null,"rs10489615-G","rs10489615",0,10489615,"intron",0,0.6,4e-09,8.39794000867203,null,0.02,"[0.01-0.03] unit increase","Affymetrix, Illumina & Perlegen [2,155,369] (imputed)","N"]
["V2 (down-regulated)","09/17/2010",20802479,"Anttila V","08/29/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20802479","Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1.","Migraine","2,731 European cases, 10,747 European controls","3,202 European cases, 40,062 European controls","8q22.1",8,98166913,"MTDH,PGCP",null,10404,85453,null,11.19,118.8,"rs1835740-A","rs1835740",0,1835740,null,1,0.21,2e-11,10.698970004336,null,1.18,"[1.13-1.24] ","Illumina [429,912]","N"]
["V2 (down-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","Cholesterol, total"," (up-regulated) to 100,184 European descent individuals",null,"1q42.3",1,234858597,"IRF2BP2,TOMM20","- ",null,null,100506810,null,null,"rs514230-A","rs514230",0,514230,"nearGene-5",0,0.48,5e-14,13.3010299956639,null,1.36,"[0.97-1.75] mg/dL decrease","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V2 (down-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","HDL cholesterol","99,900 European descent individuals",null,"1q42.13",1,230295691,"GALNT2","- ",null,null,2590,null,null,"rs4846914-G","rs4846914",0,4846914,"intron",0,0.4,4e-21,20.397940008672,null,0.61,"[0.47-0.75] mg/dL decrease","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V2 (down-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","LDL cholesterol"," (up-regulated) to 95,454 European descent individuals",null,"1q42.3",1,234858597,"IRF2BP2,TOMM20","- ",null,null,100506810,null,null,"rs514230-A","rs514230",0,514230,"nearGene-5",0,0.48,9e-12,11.0457574905606,null,1.13,"[0.78-1.48] mg/dL decrease","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V2 (down-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","Triglycerides"," (up-regulated) to 96,598 European descent individuals",null,"1q42.13",1,230295691,"GALNT2","- ",null,null,2590,null,null,"rs4846914-G ","rs4846914",0,4846914,"intron",0,0.39,2e-14,13.698970004336,null,2.76,"[2.02-3.5] mg/dL increase","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V2 (down-regulated)","06/14/2010",20463881,"Liu F","05/16/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20463881","Digital quantification of human eye color highlights genetic association of three new loci.","Eye color traits","5,951 Dutch individuals","2,261 UK twins, 1,282 Australian family members","21q22.13",21,38491095,"TTC3,DSCR9","- ",null,null,7267,null,null,"rs1003719-A","rs1003719",0,1003719,"intron",0,"NR",2e-10,9.69897000433601,"(CHS1)",0.1,"[NR] % decrease","Illumina [2,543,887] (imputed)","N"]
["V2 (down-regulated)","04/14/2010",20339536,"Barber MJ","03/22/2010","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/20339536","Genome-wide association of lipid-lowering response to statins in combined study populations.","Response to statin therapy","3,928 Caucasian individuals","NR","9q33.2",9,122861297,"MIRN147, CDK5RAP2, MEGF9",null,1620,406939,null,729.56,145.96,"rs16909449-C","rs16909449",0,16909449,null,1,0.25,1e-06,5.99999999999999,"(Triglyceride, sum)","NR","NR","Illumina [~2.5 million](imputed)","N"]
["V2 (down-regulated)","10/16/2009",19801982,"Rivadeneira F","10/04/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19801982?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.","Bone mineral density (spine)","19,195 European individuals","NR","2p16.2",2,54684557,"SPTBN1","- ",null,null,6711,null,null,"rs11898505-A","rs11898505",0,11898505,"intron",0,0.34,2e-08,7.69897000433601,null,0.07,"[0.05-0.09] s.d. increase","Affymetrix & Illumina [2,543,686](imputed)","N"]
["V2 (down-regulated)","12/29/2009",19767753,"Eeles RA","09/20/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19767753?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=6","Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.","Prostate cancer","1,854 European ancestry cases, 1,894 European ancestry controls","19,879 cases, 18,761 controls (European, Chinese, Japanese, African American, Latino, and Hawaiian ancestry)","2q31.1",2,173311553,"ITGA6","- ",null,null,3655,null,null,"rs12621278-A","rs12621278",0,12621278,"intron",0,0.94,9e-23,22.0457574905606,null,1.33,"[1.25-1.43] ","Illumina [541,129]","N"]
["V2 (down-regulated)","11/08/2012",19734545,"Need AC","09/04/2009","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19734545?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.","Cognitive performance"," (up-regulated) to 1,295 individuals","NR","2q31.1",2,171822466,"GORASP2","- ",null,null,26003,null,null,"rs4668356-?","rs4668356",0,4668356,"cds-synon",0,0.06041,1e-06,5.99999999999999,"(PAL8)","NR","NR","Illumina [475,971]","N"]
["V2 (down-regulated)","09/09/2009",19668339,"Potkin SG","08/07/2009","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/19668339?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.","Hippocampal atrophy","172 cases, 209 controls","NR","5q14.1",5,77630854,"SCAMP1, LHFPL2",null,100462732,9522,null,112.41,25.49,"rs6881634-?","rs6881634",0,6881634,null,1,"NR",2e-06,5.69897000433601,null,"NR","NR","Illumina [516,645]","N"]
["V2 (down-regulated)","09/09/2009",19668339,"Potkin SG","08/07/2009","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/19668339?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.","Hippocampal atrophy","172 cases, 209 controls","NR","12q14.3",12,67628831,"CAND1",null,23426,121328,null,555.91,30.79,"rs1082714-?","rs1082714",0,1082714,null,1,"NR",5e-06,5.30102999566398,null,"NR","NR","Illumina [516,645]","N"]
["V2 (down-regulated)","07/24/2009",19581569,"Treutlein J","07/01/2009","Arch Gen Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/19581569","Genome-wide association study of alcohol dependence.","Alcohol dependence","476 European ancestry cases, 1,358 European ancestry controls","1,024 European ancestry cases, 996 European ancestry controls","5q15",5,96111371,"CAST, ERAP1","- ",null,null,51752,null,null,"rs13160562-G","rs13160562",0,13160562,"intron",0,0.68,7e-06,5.15490195998574,null,1.27,"[1.14-1.41] ","Illumina [524,396]","N"]
["V2 (down-regulated)","05/05/2009",19396169,"Cho YS","04/26/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19396169","A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.","Biomedical quantitative traits","8,842 Korean ancestry individuals","7,861 Korean ancestry individuals","7q31.31",7,121033121,"FAM3C","- ",null,null,10447,null,null,"rs7776725-C","rs7776725",0,7776725,"intron",0,0.13,1e-11,11,"(BD-RT)","NR","NR","Affymetrix [2,156,535] (imputed)","N"]
["V2 (down-regulated)","05/05/2009",19396169,"Cho YS","04/26/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19396169","A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.","Biomedical quantitative traits","8,842 Korean ancestry individuals","7,861 Korean ancestry individuals","7q31.31",7,121033121,"FAM3C","- ",null,null,10447,null,null,"rs7776725-C","rs7776725",0,7776725,"intron",0,0.13,2e-06,5.69897000433601,"(BD-TT)","NR","NR","Affymetrix [2,156,535] (imputed)","N"]
["V2 (down-regulated)","04/22/2009",19343178,"Soranzo N","04/03/2009","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/19343178?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.","Height","12,611 individuals","7,187 individuals","14q24.3",14,75626042,"TMED10","- ",null,null,10972,null,null,"rs910316-?","rs910316",0,910316,"intron",0,0.15,1e-07,7,null,0.05,"[0.03-0.07] s.d. increase","Illumina [229,216]","N"]
["V2 (down-regulated)","04/01/2009",19247474,"Caporaso N","02/27/2009","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/19247474?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide and candidate gene association study of cigarette smoking behaviors.","Smoking behavior","4,611 individuals (2,617 smokers)","NR","3q13.12",3,107465817,"BBX","- ",null,null,56987,null,null,"rs6437740-?","rs6437740",0,6437740,"intron",0,0.24,2e-07,6.69897000433601,"(CPD)",0.1,"[NR] fewer cigarettes per day","Illumina [~518,000]","N"]
["V2 (down-regulated)","03/01/2009",19198609,"Kathiresan S","02/08/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19198609?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.","Myocardial infarction (early onset)","2,967 cases, 3,075 controls","9,746 cases, 9,746 controls","1q41",1,222823529,"MIA3","- ",null,null,375056,null,null,"rs17465637-C","rs17465637",0,17465637,"intron",0,0.72,1e-09,8.99999999999999,null,1.14,"[1.10-1.19] ","Affymetrix [~2.5 million] (imputed)","N"]
["V2 (down-regulated)","03/03/2009",19151714,"Meyre D","01/18/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19151714?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.","Obesity","695 obese adults, 685 obese children, 731 lean adults, 685 lean children","1,171 obese adults, 896 obese children, 1,114 lean adults, 1,297 lean children, 4,417 adults, 5,291 children","10p13",10,16299951,"PTER",null,100873960,9317,null,186.14,178.99,"rs10508503-C","rs10508503",0,10508503,null,1,0.91,2e-07,6.69897000433601,"(children)",1.56,"[1.10-2.78] ","Illumina [308,846]","N"]
["V2 (down-regulated)","01/16/2009",19079262,"Styrkarsdottir U","12/14/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19079262?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","New sequence variants associated with bone mineral density.","Bone mineral density (spine)","6,865 individuals","8,510 individuals","2p16.2",2,54684557,"SPTBN1","- ",null,null,6711,null,null,"rs11898505-G","rs11898505",0,11898505,"intron",0,0.68,4e-06,5.39794000867203,null,0.07,"[0.04-0.10] s.d. decrease","Illumina [305,051]","N"]
["V2 (down-regulated)","01/12/2009",19060906,"Kathiresan S","12/07/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19060906?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Common variants at 30 loci contribute to polygenic dyslipidemia.","HDL cholesterol","19,840 individuals"," (up-regulated) to 20,623 individuals","1q42.13",1,230295691,"GALNT2","- ",null,null,2590,null,null,"rs4846914-G","rs4846914",0,4846914,"intron",0,0.4,4e-08,7.39794000867203,null,0.05,"[0.01-0.09] s.d. decrease","Affymetrix and Illumina [~2,600,000] (imputed)","N"]
["V2 (down-regulated)","01/16/2009",19010793,"Baranzini SE","11/14/2008","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19010793?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.","Multiple sclerosis (severity)","794 cases, 883 controls","NR","7q31.2",7,116346603,"MET","- ",null,null,4233,null,null,"rs10243024-?","rs10243024",0,10243024,"intron",0,0.23,6e-06,5.22184874961635,null,"NR","NR","Illumina[551,642]","N"]
["V2 (down-regulated)","12/09/2008",18951430,"Anney RJ","10/24/2008","Am J Med Genet B Neuropsychiatr Genet","http://www.ncbi.nlm.nih.gov/pubmed/18951430?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.","Attention deficit hyperactivity disorder and conduct disorder","938 affected trios","NR","8q22.3",8,101919321,"YWHAZ",null,392256,7534,null,10.89,11.48,"rs931812-C","rs931812",0,931812,null,1,0.74,5e-06,5.30102999566398,null,"NR","NR","Perlegen[378,332]","N"]
["V2 (down-regulated)","12/01/2008",18940312,"Yuan X","10/10/2008","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/18940312","Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.","Liver enzyme levels","7,751 European ancestry individuals","4,704 European ancestry and Asian Indian individuals","10q24.2",10,101861435,"CPN1, CHUK, ERLIN1",null,1369,10613,null,19.79,48.41,"rs11597390-A","rs11597390",0,11597390,null,1,0.36,2e-08,7.69897000433601,"(ALT)",0.04,"[0.025-0.053] U/L decrease","Affymetrix and Illumina[ (up-regulated) to 496,032]","N"]
["V2 (down-regulated)","05/07/2009",18839057,"Lesch KP","10/07/2008","J Neural Transm","http://www.ncbi.nlm.nih.gov/pubmed/18839057?ordinalpos=16&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.","Attention deficit hyperactivity disorder","343 cases, 304 controls","NR","5q22.2",5,112242968,"REEP5","- ",null,null,7905,null,null,"rs469727-?","rs469727",0,469727,"intron",0,"NR",8e-06,5.09691001300805,null,"NR","NR","Affymetrix [504,219](pooled)","N"]
["V2 (down-regulated)","11/25/2008",18445777,"Styrkarsdottir U","04/29/2008","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/18445777?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Multiple genetic loci for bone mineral density and fractures.","Bone mineral density (spine)","5,861 individuals","7,925 individuals","2p16.2",2,54684557,"SPTBN1","- ",null,null,6711,null,null,"rs11898505-G","rs11898505",0,11898505,"intron",0,0.67,8e-07,6.09691001300805,null,0.08,"[0.05-0.11] s.d. decrease","Illumina[301,019]","N"]
["V2 (down-regulated)","11/25/2008",18391951,"Gudbjartsson DF","04/06/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18391951?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Many sequence variants affecting diversity of adult human height.","Height","30,968 individuals","8,541 individuals","12q15",12,69828681,"LYZ,YEATS4,FRS2,CPSF6,CCT2,LRRC10",null,100271570,10818,null,11.91,35.45,"rs11177669-A","rs11177669",0,11177669,null,1,0.31,3e-06,5.52287874528033,null,4.5,"[2.54-6.46] % s.d. taller","Illumina and Affymetrix[ (up-regulated) to 304,226]","N"]
["V2 (down-regulated)","11/25/2008",18391951,"Gudbjartsson DF","04/06/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18391951?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Many sequence variants affecting diversity of adult human height.","Height","30,968 individuals","8,541 individuals","8q12.1",8,57095808,"PLAG1, MOS, CHCHD7,RDHE2, RPS20,LYN, TGS1, PENK","- ",null,null,5324,null,null,"rs10958476-C","rs10958476",0,10958476,"intron",0,0.23,7e-08,7.15490195998574,null,5.4,"[3.44-7.36] % s.d. taller","Illumina and Affymetrix[ (up-regulated) to 304,226]","N"]
["V2 (down-regulated)","11/25/2008",18391950,"Lettre G","04/06/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18391950?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Identification of ten loci associated with height highlights new biological pathways in human growth.","Height","15,821 individuals","13,671 individuals","9q34.11",9,133464084,"FUBP3","- ",null,null,8939,null,null,"rs7466269-G","rs7466269",0,7466269,"intron",0,0.33,8e-07,6.09691001300805,null,0.27,"[0.38-0.69] cm shorter","Affymetrix and Illumina[2,260,683](imputed)","N"]
["V2 (down-regulated)","11/25/2008",18193044,"Kathiresan S","01/13/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18193044?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.","HDL cholesterol","2,758 individuals","18,544 individuals","1q42.13",1,230295691,"GALNT2","- ",null,null,2590,null,null,"rs4846914-G","rs4846914",0,4846914,"intron",0,0.4,2e-13,12.698970004336,null,0.07,"[0.05-0.09] % SD lower","Affymetrix[389,878]","N"]
["V2 (down-regulated)","11/25/2008",18193044,"Kathiresan S","01/13/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18193044?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.","Triglycerides","2,758 individuals","18,544 individuals","1q42.13",1,230295691,"GALNT2","- ",null,null,2590,null,null,"rs4846914-G","rs4846914",0,4846914,"intron",0,0.4,7e-15,14.1549019599857,null,0.08,"[0.06-0.10] % SD higher","Affymetrix[389,878]","N"]
["V2 (down-regulated)","11/25/2008",18193043,"Willer CJ","01/13/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18193043?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Newly identified loci that influence lipid concentrations and risk of coronary artery disease.","HDL cholesterol","8,656 individuals","11,399 individuals","1q42.13",1,230294916,"GALNT2","- ",null,null,2590,null,null,"rs2144300-T","rs2144300",0,2144300,"intron",0,0.6,3e-14,13.5228787452803,null,1.11,"[NR] mg/dl higher","Illumina and Affymetrix[~2,261,000] (imputed)","N"]
["V2 (down-regulated)","11/25/2008",18193043,"Willer CJ","01/13/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18193043?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Newly identified loci that influence lipid concentrations and risk of coronary artery disease.","Triglycerides","8,684 individuals","5,312-9,707 individuals","1q42.13",1,230294916,"GALNT2","- ",null,null,2590,null,null,"rs2144300-C","rs2144300",0,2144300,"intron",0,0.4,8e-07,6.09691001300805,null,4.25,"[NR] mg/dl higher","Illumina and Affymetrix[~2,261,000]] (imputed)","N"]
["V2 (down-regulated)","11/25/2008",17903295,"Lunetta KL","09/19/2007","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/17903295?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study.","Aging traits","1,345 individuals(Framingham)","NR","2q24.1",2,155070567,"GALNT13","- ",null,null,114805,null,null,"rs958672-?","rs958672",0,958672,"intron",0,"NR",2e-06,5.69897000433601,"(age at natural menopause)","NR","NR","Affymetrix[70,897]","N"]
["V2 (down-regulated)","11/25/2008",17634449,"Samani NJ","07/18/2007","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/17634449?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genomewide association analysis of coronary artery disease.","Coronary heart disease","1,926 cases,2,938 controls","875 cases,1,644 controls","1q41",1,222823529,"MIA3","- ",null,null,375056,null,null,"rs17465637-C","rs17465637",0,17465637,"intron",0,0.71,1e-06,5.99999999999999,null,1.2,"[1.12-1.30] ","Affymetrix [377,857]","N"]
["V3 (up-regulated)","06/26/2013",23535033,"Sherva R","03/24/2013","Alzheimers Dement","http://www.ncbi.nlm.nih.gov/pubmed/23535033","Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.","Alzheimer's disease (cognitive decline)","303 European ancestry cases",null,"3p22.1",3,39513278,"MOBP","- ",null,null,4336,null,null,"rs538867-?","rs538867",0,538867,"intron",0,0.03,1e-07,7,null,0.26,"unit decrease","Illumina [NR] (Imputed)","N"]
["V3 (up-regulated)","06/26/2013",23535033,"Sherva R","03/24/2013","Alzheimers Dement","http://www.ncbi.nlm.nih.gov/pubmed/23535033","Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.","Alzheimer's disease (cognitive decline)","303 European ancestry cases",null,"5q11.2",5,55510656,"ANKRD55","- ",null,null,79722,null,null,"rs4700060-?","rs4700060",0,4700060,"intron",0,0.1,1e-08,8,null,0.21,"unit decrease","Illumina [NR] (Imputed)","N"]
["V3 (up-regulated)","06/14/2013",23459443,"Avery CL","03/05/2013","Pharmacogenomics J","http://www.ncbi.nlm.nih.gov/pubmed/23459443","Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval.","QT interval (interaction)","33,781 Euroepan ancestry individuals",null,"6q22.1",6,117730819,"ROS1","- ",null,null,6098,null,null,"rs2273601-A","rs2273601",0,2273601,"intron",0,0.23,8e-06,5.09691001300805,"(UAZ Cert)","NR","NR","Illumina & Affymetrix [~2.5 Million] (imputed)","N"]
["V3 (up-regulated)","06/11/2013",23459936,"Divaris K","03/04/2013","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23459936","Exploring the genetic basis of chronic periodontitis: a genome-wide association study.","Periodontitis","4,504 European ancestry individuals","656 European ancestry and African American individuals","19p13.3",19,6887736,"EMR1, VAV1","- ",null,null,2015,null,null,"rs3826782-?","rs3826782",0,3826782,"intron",0,"NR",8e-07,6.09691001300805,"(Moderate CPd)",2.01,"[1.52-2.65] ","Affymetrix [2,135,236] (imputed)","N"]
["V3 (up-regulated)","05/31/2013",23449627,"Cousminer DL","02/27/2013","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23449627","Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.","Pubertal anthropometrics","7,161 European ancestry males, 6,879 European ancestry females","5,133 European ancestry males, 4,577 European ancestry females","12p12.3",12,14966604,"C12orf60,HIST4H4","- ",null,null,"144608;440087",null,null,"rs4764124-C","rs4764124",0,4764124,"intron;intron",0,0.52,8e-07,6.09691001300805,"(Single Height)",0.05,"[0.03-0.07] unit increase","Illumina & Affymetrix [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","06/06/2013",23453885,"Smoller JW","02/27/2013","Lancet","http://www.ncbi.nlm.nih.gov/pubmed/23453885","Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.","Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined)","6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls","NR","10q21.2",10,62279124,"ANK3","- ",null,null,288,null,null,"rs10994397-?","rs10994397",0,10994397,"intron",0,0.065,7e-09,8.15490195998574,null,"NR","NR","NR [1,252,901] (imputed)","N"]
["V3 (up-regulated)","06/06/2013",23453885,"Smoller JW","02/27/2013","Lancet","http://www.ncbi.nlm.nih.gov/pubmed/23453885","Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.","Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined)","6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls","NR","10q21.2",10,62222107,"ANK3","- ",null,null,288,null,null,"rs10994359-C","rs10994359",0,10994359,"intron",0,"NR",3e-09,8.52287874528033,"(5 degree of freedom test)",1.08,"[1.03-1.13] ","NR [1,252,901] (imputed)","N"]
["V3 (up-regulated)","06/06/2013",23453885,"Smoller JW","02/27/2013","Lancet","http://www.ncbi.nlm.nih.gov/pubmed/23453885","Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.","Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined)","6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls","NR","3p21.1",3,52833219,"ITIH3","- ",null,null,3699,null,null,"rs2535629-?","rs2535629",0,2535629,"intron",0,0.651,3e-12,11.5228787452803,null,1.1,"[1.07-1.12] ","NR [1,252,901] (imputed)","N"]
["V3 (up-regulated)","06/04/2013",23432519,"O'Brien RP","02/21/2013","Clin Transplant","http://www.ncbi.nlm.nih.gov/pubmed/23432519","A genome-wide association study of recipient genotype and medium-term kidney allograft function.","Renal transplant outcome","263 European ancestry individuals",null,"14q11.2",14,22481824,"TRAV19, TRAV20",null,28664,28663,null,5.4,27.09,"rs3811321-C","rs3811321",0,3811321,null,1,"NR",8e-08,7.09691001300805,"(Five-year creatinine)",0.48,"[NR] unit increase","Illumina [511,662]","N"]
["V3 (up-regulated)","05/11/2013",23400010,"Del-Aguila JL","02/12/2013","Pharmacogenomics J","http://www.ncbi.nlm.nih.gov/pubmed/23400010","Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.","Thiazide-induced adverse metabolic effects in hypertensive patients","425 European ancestry cases, 342 African American cases","NR","8q22.2",8,99317739,"NIPAL2",null,79815,3788,null,11.12,121.51,"rs11785622-T","rs11785622",0,11785622,null,1,0.07,4e-06,5.39794000867203,"(AA-glucose response) ",7.21,"[4.15-10.27] mg/dL decrease","Illumina and Affymetrics [>2 million] (Imputed)","N"]
["V3 (up-regulated)","05/14/2013",23408906,"Porcu E","02/07/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23408906","A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.","Thyroid hormone levels"," (up-regulated) to 12,289 European ancestry females,  (up-regulated) to 9,019 European ancestry males,  (up-regulated) to 433 Old Order Amish females,  (up-regulated) to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males","NR","9q34.3",9,139089679,"LHX3 ","- ",null,null,8022,null,null,"rs7860634-A ","rs7860634",0,7860634,"intron",0,0.53,5e-08,7.30102999566398,"(FT4-Females)",0.1,"[0.063-0.133] unit increase","Illumina, Affymetrix [~2.5 Million] (Imputed)","N"]
["V3 (up-regulated)","05/14/2013",23408906,"Porcu E","02/07/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23408906","A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.","Thyroid hormone levels"," (up-regulated) to 12,289 European ancestry females,  (up-regulated) to 9,019 European ancestry males,  (up-regulated) to 433 Old Order Amish females,  (up-regulated) to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males","NR","9q34.3",9,139089679,"LHX3 ","- ",null,null,8022,null,null,"rs7860634-A ","rs7860634",0,7860634,"intron",0,0.53,2e-08,7.69897000433601,"(FT4-Males)",0.11,"[0.071-0.145] unit increase","Illumina, Affymetrix [~2.5 Million] (Imputed)","N"]
["V3 (up-regulated)","05/14/2013",23408906,"Porcu E","02/07/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23408906","A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.","Thyroid hormone levels"," (up-regulated) to 12,289 European ancestry females,  (up-regulated) to 9,019 European ancestry males,  (up-regulated) to 433 Old Order Amish females,  (up-regulated) to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males","NR","9q34.3",9,139089679,"LHX3 ","- ",null,null,8022,null,null,"rs7860634-A ","rs7860634",0,7860634,"intron",0,0.53,2e-14,13.698970004336,"(FT4)",0.1,"[0.077-0.127] unit increase","Illumina, Affymetrix [~2.5 Million] (Imputed)","N"]
["V3 (up-regulated)","05/08/2013",23571483,"Aberg KA","02/01/2013","JAMA Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23571483","A comprehensive family-based replication study of schizophrenia genes.","Schizophrenia","11,185 European ancestry cases, 10,768 European ancestry controls","1,262 African American ancestry individuals, 2,740 European ancestry individuals, 2,296 Asian ancestry individuals","6p21.32",6,32171075,"NOTCH4","- ",null,null,4855,null,null,"rs3132935-?","rs3132935",0,3132935,"intron",0,0.82,3e-07,6.52287874528033,null,1.25,"[NR] ","NR [1,085,772] (Imputed)","N"]
["V3 (up-regulated)","05/08/2013",23571483,"Aberg KA","02/01/2013","JAMA Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23571483","A comprehensive family-based replication study of schizophrenia genes.","Schizophrenia","11,185 European ancestry cases, 10,768 European ancestry controls","1,262 African American ancestry individuals, 2,740 European ancestry individuals, 2,296 Asian ancestry individuals","6p22.1",6,27278020,"POM121L2","- ",null,null,94026,null,null,"rs16897515-C","rs16897515",0,16897515,"missense",0,0.16,4e-07,6.39794000867203,"(EA)",1.3,"[NR] ","NR [1,085,772] (Imputed)","N"]
["V3 (up-regulated)","05/08/2013",23571483,"Aberg KA","02/01/2013","JAMA Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23571483","A comprehensive family-based replication study of schizophrenia genes.","Schizophrenia","11,185 European ancestry cases, 10,768 European ancestry controls","1,262 African American ancestry individuals, 2,740 European ancestry individuals, 2,296 Asian ancestry individuals","6p21.32",6,32171075,"NOTCH4","- ",null,null,4855,null,null,"rs3132935-?","rs3132935",0,3132935,"intron",0,0.82,5e-07,6.30102999566398,"(EA)",1.25,"[NR] ","NR [1,085,772] (Imputed)","N"]
["V3 (up-regulated)","05/09/2013",23377640,"GENDEP Investigators","02/01/2013","Am J Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23377640 ","Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.","Major depressive disorder"," (up-regulated) to 2,256 European ancestry cases","NR","1q41",1,217200883,"ESRRG","- ",null,null,2104,null,null,"rs2377360-G","rs2377360",0,2377360,"intron",0,0.2632403,9e-06,5.04575749056067,"(remission - SSRI treated - 12 weeks)",1.6,"[1.39-1.81] ","Illumina & Affymetrix [1.2 million] (Imputed)","N"]
["V3 (up-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"5q11.2",5,55322895,"IL6ST,ANKRD55",null,3572,727984,null,32.07,109.88,"rs17348299-C","rs17348299",0,17348299,null,1,0.836731980863373,2e-07,6.69897000433601,"(IGP17)",0.23,"[0.14-0.32] unit increase","Illumina [~2.5 Million] (Imputed)","N"]
["V3 (up-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"5q11.2",5,55322895,"IL6ST,ANKRD55",null,3572,727984,null,32.07,109.88,"rs17348299-C","rs17348299",0,17348299,null,1,0.836657880517164,4e-06,5.39794000867203,"(IGP75)",0.21,"[0.12-0.29] unit decrease","Illumina [~2.5 Million] (Imputed)","N"]
["V3 (up-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"5q11.2",5,55322895,"IL6ST,ANKRD55",null,3572,727984,null,32.07,109.88,"rs17348299-C","rs17348299",0,17348299,null,1,0.836659126892253,2e-09,8.69897000433601,"(IGP3)",0.27,"[0.18-0.35] unit decrease","Illumina [~2.5 Million] (Imputed)","N"]
["V3 (up-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"9p13.3",9,36099399,"RECK","- ",null,null,8434,null,null,"rs4878639-C","rs4878639",0,4878639,"intron",0,0.263725273253227,4e-08,7.39794000867203,"(IGP17)",0.2,"[0.13-0.27] unit decrease","Illumina [~2.5 Million] (Imputed)","N"]
["V3 (up-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"5q11.2",5,55322895,"IL6ST,ANKRD55",null,3572,727984,null,32.07,109.88,"rs17348299-C","rs17348299",0,17348299,null,1,0.836731980863373,1e-10,10,"(IGP55)",0.29,"[0.2-0.37] unit decrease","Illumina [~2.5 Million] (Imputed)","N"]
["V3 (up-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"5q11.2",5,55322895,"IL6ST,ANKRD55",null,3572,727984,null,32.07,109.88,"rs17348299-C","rs17348299",0,17348299,null,1,0.836660240071397,8e-06,5.09691001300805,"(IGP56)",0.2,"[0.11-0.29] unit increase","Illumina [~2.5 Million] (Imputed)","N"]
["V3 (up-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"5q11.2",5,55322895,"IL6ST,ANKRD55",null,3572,727984,null,32.07,109.88,"rs17348299-C","rs17348299",0,17348299,null,1,0.836731980863373,1e-10,10,"(IGP57)",0.29,"[0.2-0.37] unit increase","Illumina [~2.5 Million] (Imputed)","N"]
["V3 (up-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"5q11.2",5,55322895,"IL6ST,ANKRD55",null,3572,727984,null,32.07,109.88,"rs17348299-C","rs17348299",0,17348299,null,1,0.836731980863373,7e-11,10.1549019599857,"(IGP53)",0.29,"[0.2-0.38] unit increase","Illumina [~2.5 Million] (Imputed)","N"]
["V3 (up-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"9p13.3",9,36099399,"RECK","- ",null,null,8434,null,null,"rs4878639-C","rs4878639",0,4878639,"intron",0,0.263725273253227,6e-07,6.22184874961635,"(IGP53)",0.18,"[0.11-0.25] unit decrease","Illumina [~2.5 Million] (Imputed)","N"]
["V3 (up-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"5q11.2",5,55322895,"IL6ST,ANKRD55",null,3572,727984,null,32.07,109.88,"rs17348299-C","rs17348299",0,17348299,null,1,0.836731980863373,1e-10,10,"(IGP13)",0.29,"[0.2-0.38] unit increase","Illumina [~2.5 Million] (Imputed)","N"]
["V3 (up-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"9p13.3",9,36099399,"RECK","- ",null,null,8434,null,null,"rs4878639-C","rs4878639",0,4878639,"intron",0,0.263725273253227,6e-06,5.22184874961635,"(IGP13)",0.16,"[0.092-0.231] unit decrease","Illumina [~2.5 Million] (Imputed)","N"]
["V3 (up-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"5q11.2",5,55322895,"IL6ST,ANKRD55",null,3572,727984,null,32.07,109.88,"rs17348299-C","rs17348299",0,17348299,null,1,0.836731980863373,3e-10,9.52287874528033,"(IGP43)",0.28,"[0.19-0.37] unit decrease","Illumina [~2.5 Million] (Imputed)","N"]
["V3 (up-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"9p13.3",9,36099399,"RECK","- ",null,null,8434,null,null,"rs4878639-C","rs4878639",0,4878639,"intron",0,0.263725273253227,1e-06,5.99999999999999,"(IGP57)",0.17,"[0.1-0.24] unit decrease","Illumina [~2.5 Million] (Imputed)","N"]
["V3 (up-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"5q11.2",5,55322895,"IL6ST,ANKRD55",null,3572,727984,null,32.07,109.88,"rs17348299-C","rs17348299",0,17348299,null,1,0.836804684351315,2e-06,5.69897000433601,"(IGP69)",0.21,"[0.12-0.3] unit decrease","Illumina [~2.5 Million] (Imputed)","N"]
["V3 (up-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"5q11.2",5,55322895,"IL6ST,ANKRD55",null,3572,727984,null,32.07,109.88,"rs17348299-C","rs17348299",0,17348299,null,1,0.836669484361037,2e-06,5.69897000433601,"(IGP74)",0.21,"[0.13-0.3] unit decrease","Illumina [~2.5 Million] (Imputed)","N"]
["V3 (up-regulated)","06/06/2013",23362303,"Wu JH","01/29/2013","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/23362303 ","Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.","Palmitic acid (16:0) plasma levels","8,961 European ancestry individuals",null,"9p23",9,11402319,"PTPRD ",null,5789,7306,null,789.6,1291.07,"rs10809457-T ","rs10809457 ",0,10809457,null,1,"NR ",9e-07,6.04575749056067,null,0.14,"unit decrease ","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","04/17/2013",23341777,"Dong J","01/17/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23341777","Genome-wide association study identifies a novel susceptibility locus at 12q23.1 for lung squamous cell carcinoma in han chinese.","Squamous cell carcinoma","833 Han Chinese cases, 3,094 Han Chinese controls","2,223 Han Chinese cases, 6,409 Han Chinese controls","12q23.1",12,100820085,"SLC17A8, NR1H4, SCYL2, GAS2L3",null,246213,9971,null,4.25,47.47,"rs12296850-A","rs12296850",0,12296850,null,1,0.744,1e-10,10,null,1.28,"[1.19-1.39] ","Affymetrix [570,009] ","N"]
["V3 (up-regulated)","04/04/2013",23319000,"Luykx JJ","01/15/2013","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23319000 ","Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.","Metabolite levels (5-HIAA/ MHPG Ratio)"," (up-regulated) to 398 European individuals","NR","2q36.3",2,228092035,"COL4A3, BC035052, AK056332","- ",null,null,1285,null,null,"rs35212277-A","rs35212277",0,35212277,"intron",0,"NR",9e-06,5.04575749056067,null,0.27,"unit increase","Illumina [5,767,231] (Imputed)","N"]
["V3 (up-regulated)","04/04/2013",23319000,"Luykx JJ","01/15/2013","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23319000 ","Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.","Metabolite levels (HVA/MHPG ratio)"," (up-regulated) to 398 European individuals","NR","2p16.3",2,50760503,"NRXN1","- ",null,null,9378,null,null,"rs6750634-A","rs6750634",0,6750634,"intron",0,"NR",4e-06,5.39794000867203,null,0.29,"unit decrease","Illumina [5,767,231] (Imputed)","N"]
["V3 (up-regulated)","04/19/2013",23326517,"Holliday EG","01/11/2013","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23326517","Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.","Age-related macular degeneration","3,772 European ancestry cases, 16,033 European ancestry controls","264 Asian ancestry cases, 3,926 Asian ancestry controls","11q14.1",11,82821382,"PCF11, RAB30",null,1333,100127960,null,3.36,21.7,"rs4293143-?","rs4293143",0,4293143,null,1,0.31,8e-06,5.09691001300805,"(EA)",1.18,"[1.1-1.27] ","Illumina & Affymetrix [~2.5 million] Imputed","N"]
["V3 (up-regulated)","03/22/2013",23303382,"Hong KW","01/10/2013","J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23303382 ","Genome-wide association study of serum albumin:globulin ratio in Korean populations.","Hematology traits","4,637 East Asian ancestry individuals","4,205 East Asian ancestry individuals","6p25.3",6,252145,"IRF4",null,26685,56940,null,145.29,39.96,"rs6927090-A","rs6927090",0,6927090,null,1,0.282,4e-06,5.39794000867203,"(ALB/GLB)",0.02,"[0.0091-0.0209] unit increase","Affymetrix [290,659]","N"]
["V3 (up-regulated)","05/01/2013",23326239,"Rubicz R","01/10/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23326239","A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1).","Epstein-Barr virus immune response (EBNA-1)","1,367 Mexican American indivduals","589 Mexican American indivduals","6p21.32",6,32628428,"HLA-DQB1, C6orf15, PSORS1C1, HLA-B, BAT2, BAT4, EHMT2, PRRT1, NOTCH4, ","- ",null,null,3119,null,null,"rs2854275-T","rs2854275",0,2854275,"intron",0,0.064,2e-10,9.69897000433601,"(Conditional on rs477515 - Quantitative)",0.45,"[NR] unit decrease","Illumina [944,565]","N"]
["V3 (up-regulated)","03/28/2013",23291589,"Lu Y","01/06/2013","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23291589 ","Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.","Corneal structure","13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals","NR","2q36.3",2,228135180,"COL4A3","- ",null,null,"1285;654841",null,null,"rs7606754-A","rs7606754",0,7606754,"intron;intron",0,0.35,1e-09,8.99999999999999,null,0.07,"[0.05-0.09] unit decrease","Illumina & Affymetrix [~1 Million] (Imputed)","N"]
["V3 (up-regulated)","02/21/2013",23273568,"Yang W","12/27/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23273568","Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic l (up-regulated)us erythematosus in Asians.","Systemic l (up-regulated)us erythematosus","1,656 Han Chinese cases, 3,394 Han Chinese controls","3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls","6q23.3",6,138196066,"TNFAIP3","- ",null,null,7128,null,null,"rs2230926-G","rs2230926",0,2230926,"missense",0,0.02,1e-13,13,null,2.71,null,"Illumina [2,100,739] (imputed)","N"]
["V3 (up-regulated)","03/15/2013",23263486,"Kottgen A","12/23/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263486","Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.","Urate levels","49,825 European ancestry men, 60,522 European ancestry women"," (up-regulated) to 32,813 European ancestry individuals","2q23.1",2,148716428,"ORC4L, ACVR2A","- ",null,null,5000,null,null,"rs2307394-T","rs2307394",0,2307394,"missense",0,0.68,2e-08,7.69897000433601,null,0.03,"[0.019-0.039] mg/dl decrease","Affymetrix, Illumina, Perlegen [2,450,547] (imputed)","N"]
["V3 (up-regulated)","03/15/2013",23263486,"Kottgen A","12/23/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263486","Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.","Urate levels","49,825 European ancestry men, 60,522 European ancestry women"," (up-regulated) to 32,813 European ancestry individuals","7q36.1",7,151406005,"PRKAG2","- ",null,null,51422,null,null,"rs10480300-T","rs10480300",0,10480300,"intron",0,0.28,4e-09,8.39794000867203,null,0.04,"[0.023-0.047] mg/dl increase","Affymetrix, Illumina, Perlegen [2,450,547] (imputed)","N"]
["V3 (up-regulated)","03/15/2013",23263486,"Kottgen A","12/23/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263486","Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.","Urate levels","49,825 European ancestry men, 60,522 European ancestry women"," (up-regulated) to 32,813 European ancestry individuals","5q11.2",5,55811092,"ANKRD55",null,441073,4214,null,10.15,299.81,"rs456867-T","rs456867",0,456867,null,1,0.17,3e-06,5.52287874528033,"(women)",0.04,"[0.022-0.054] mg/dl decrease","Affymetrix, Illumina, Perlegen [2,450,547] (imputed)","N"]
["V3 (up-regulated)","02/27/2013",23266558,"Yamazaki K","12/21/2012","Gastroenterology","http://www.ncbi.nlm.nih.gov/pubmed/23266558","A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.","Crohn's disease","372 Japanese ancestry cases and 3,389 Japanese ancestry controls"," (up-regulated) to 1,151 Japanese ancestry cases and  (up-regulated) to 15,800 Japanese ancestry controls","6p21.32",6,32205110,"PBX2, NOTCH4",null,4855,100131609,null,13.27,88.07,"rs9267911-T","rs9267911",0,9267911,null,1,0.479,3e-07,6.52287874528033,null,1.5,"[1.29-1.76] ","Illumina [4,929,034] (imputed)","N"]
["V3 (up-regulated)","02/27/2013",23284291,"Hancock DB","12/20/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23284291 ","Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.","Pulmonary function (interaction)","50,047 European ancestry individuals","NR","9q33.1",9,119314217,"ASTN2","- ",null,null,"23245;100128505",null,null,"rs13290997-A ","rs13290997   ",0,13290997,"intron;intron",0,"NR",5e-07,6.30102999566398,"(FEV1, Pack-years)","NR","NR","NR [~2.5 Million] (imputed)","N"]
["V3 (up-regulated)","02/27/2013",23247143,"Yu B","12/16/2012","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/23247143","Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.","Cardiac Troponin-T levels","9,491 European ancestry individuals,  (up-regulated) to 2,053 African American individuals","NR","6q23.3",6,138266685,"TNFAIP3",null,7128,100270919,null,62.23,49.72,"rs9321637-C","rs9321637",0,9321637,null,1,"NR",8e-06,5.09691001300805,"(Dichotomous variable)",2.17,"[1.56-3.13] ","Affymetrix and Illumina [~2.5 Million] (imputed)","N"]
["V3 (up-regulated)","03/19/2013",23222517,"van der Harst P","12/05/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23222517","Seventy-five genetic loci influencing the human red blood cell.","Red blood cell traits","62,553 European ancestry individuals, 9,308 South Asian ancestry individuals","63,506 European ancestry individuals","7q36.1",7,151406005,"PRKAG2","- ",null,null,51422,null,null,"rs10480300-C","rs10480300",0,10480300,"intron",0,0.72,8e-15,14.096910013008,"(EA, Hgb)",0.05,"[0.038-0.066] unit increase","Illumina, Affymetrix & Perlegen [2,711,806] imputed","N"]
["V3 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","11q22.3",11,106523224,"GUCY1A2",null,60496,2977,null,553.81,21.51,"rs12364992-G","rs12364992",0,12364992,null,1,0.176,6e-06,5.22184874961635,"(Hip circumference change )",0.03,"[NR]  cm/y increase","Illumina [899,892]","N"]
["V3 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","6p21.32",6,32163748,"NOTCH4, GPSM3","- ",null,null,"4855;63940",null,null,"rs13215567-A","rs13215567",0,13215567,"cds-synon;nearGene-5",0,0.049,1e-06,5.99999999999999,"(IGFBP-3 )",0.03,"[NR]  ng/mL increase","Illumina [899,892]","N"]
["V3 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","2q13",2,113890373,"IL1RN","- ",null,null,3557,null,null,"rs4252023-A","rs4252023",0,4252023,"cds-synon",0,0.058,2e-06,5.69897000433601,"(IGFBP-3 )",0.03,"[NR]  ng/mL increase","Illumina [899,892]","N"]
["V3 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","20p12.1",20,17436473,"PCSK2","- ",null,null,5126,null,null,"rs6044834-C","rs6044834",0,6044834,"intron",0,0.069,8e-08,7.09691001300805,"(Total antioxidants )",0.04,"[NR]  mM increase","Illumina [899,892]","N"]
["V3 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","9q33.1",9,119839328,"ASTN2","- ",null,null,23245,null,null,"rs16934284-G","rs16934284",0,16934284,"intron",0,0.085,2e-06,5.69897000433601,"(AST )",0.03,"[NR]  U/L increase","Illumina [899,892]","N"]
["V3 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","10q26.3",10,135352153,"CYP2E1","- ",null,null,1571,null,null,"rs2249694-A","rs2249694",0,2249694,"intron",0,0.225,3e-06,5.52287874528033,"(Height z-score )",0.03,"[NR]  SD increase","Illumina [899,892]","N"]
["V3 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","11q23.3",11,117851052,"IL10RA",null,84000,3587,null,50.88,6.05,"rs58603829-A","rs58603829",0,58603829,null,1,0.028,6e-06,5.22184874961635,"(Folate )",0.03,"[NR]  nmol/L increase","Illumina [899,892]","N"]
["V3 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","9p23",9,10139580,"PTPRD","- ",null,null,5789,null,null,"rs294845-A","rs294845",0,294845,"intron",0,0.239,7e-06,5.15490195998574,"(Dinner intake, adj TEE )",0.04,"[NR]  kcal increase","Illumina [899,892]","N"]
["V3 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","10q24.1",10,97229762,"SORBS1","- ",null,null,10580,null,null,"rs579342-A","rs579342",0,579342,"intron",0,0.041,4e-06,5.39794000867203,"(Height z-score change )",0.03,"[NR]  SD/y increase","Illumina [899,892]","N"]
["V3 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","6q23.2",6,132228769,"ENPP1",null,5167,1490,null,12.47,40.55,"rs6907728-C","rs6907728",0,6907728,null,1,0.186,3e-06,5.52287874528033,"(CRP )",0.04,"[NR]  ng/mL increase","Illumina [899,892]","N"]
["V3 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","1p33",1,50607029,"ELAVL4","- ",null,null,1996,null,null,"rs12092053-C","rs12092053",0,12092053,"intron",0,0.004,6e-06,5.22184874961635,"(IGFBP-1 )",0.02,"[NR]  ng/mL increase","Illumina [899,892]","N"]
["V3 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","6p22.3",6,20382600,"E2F3",null,154141,1871,null,169.93,19.54,"rs1570155-A","rs1570155",0,1570155,null,1,0.391,4e-06,5.39794000867203,"(Calorimeter activity )",0.04,"[NR]  counts/d increase","Illumina [899,892]","N"]
["V3 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","10q23.1",10,86588902,"RPS3AP5",null,439992,100507470,null,267.84,748.59,"rs11201253-A","rs11201253",0,11201253,null,1,0.162,6e-06,5.22184874961635,"(TSH )",0.02,"[NR]  礗U/mL increase","Illumina [899,892]","N"]
["V3 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","1q43",1,241755567,"KMO","- ",null,null,8564,null,null,"rs1053221-G","rs1053221",0,1053221,"UTR-3",0,0.111,1e-06,5.99999999999999,"(Urinary creatinine )",0.04,"[NR]  mmol/d increase","Illumina [899,892]","N"]
["V3 (up-regulated)","02/01/2013",23143601,"Lan Q","11/11/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23143601","Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.","Lung cancer","5,510 East Asian ancestry cases, 4,544 East Asian ancestry controls","1,099 East Asian ancestry cases, 2,913 East Asian ancestry controls","6q22.1",6,117786180,"ROS1, DCBLD1",null,6098,285761,null,39.16,17.64,"rs9387478-C","rs9387478",0,9387478,null,1,0.5,4e-10,9.39794000867203,null,1.18,"[1.11-1.23] ","Illumina [596,032]","N"]
["V3 (up-regulated)","02/01/2013",23143601,"Lan Q","11/11/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23143601","Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.","Lung cancer","5,510 East Asian ancestry cases, 4,544 East Asian ancestry controls","1,099 East Asian ancestry cases, 2,913 East Asian ancestry controls","2q23.3",2,152253918,"TNFAIP6, RIF1",null,7130,55183,null,17.36,12.48,"rs10197940-T","rs10197940",0,10197940,null,1,0.52,5e-06,5.30102999566398,null,1.12,"[1.06-1.18] ","Illumina [596,032]","N"]
["V3 (up-regulated)","01/25/2013",23144319,"Lee Y","11/08/2012","Carcinogenesis","http://www.ncbi.nlm.nih.gov/pubmed/23144319","Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study.","Non-small cell lung cancer","348 Korean ancestry cases","NR","19p13.3",19,348743,"MIER2",null,54531,51298,null,3.95,13.31,"rs6510725-?","rs6510725",0,6510725,null,1,"NR",3e-06,5.52287874528033,"(Dominant model)","NR","NR","Affymetrix [271,817]","N"]
["V3 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","14q24.3",14,75701221,"FOS,MLH3",null,10972,2353,null,57.87,44.26,"rs4899554-C","rs4899554",0,4899554,null,1,0.819,3e-08,7.52287874528033,null,1.08,"[1.042-1.125] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V3 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","4q13.3",4,74857708,"CXCL5,CXCL1,CXCL3,IL8,CXCL6,PF4,CXCL2,PF4V1",null,5473,6374,null,3.8,3.65,"rs2472649-G","rs2472649",0,2472649,null,1,0.824,3e-08,7.52287874528033,null,1.1,"[1.046-1.146] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V3 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","6q23.3",6,138006504,"TNFAIP3",null,391040,7128,null,140.92,181.82,"rs6920220-A","rs6920220",0,6920220,null,1,0.206,1e-21,21,null,1.1,"[1.064-1.141] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V3 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","16p12.2",16,23864590,"PRKCB","- ",null,null,5579,null,null,"rs7404095-C","rs7404095",0,7404095,"intron",0,0.572,1e-09,8.99999999999999,null,1.06,"[1.03-1.091] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V3 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","2q12.1",2,103070568,"IL1R2,IL18RAP,IL18R1,IL1R1,IL1RL1,IL1RL2",null,8807,389015,null,1.54,19.19,"rs917997-T","rs917997",0,917997,null,1,0.231,3e-20,19.5228787452803,null,1.1,"[1.067-1.14] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V3 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","1q23.3",1,161479745,"FCGR2A,FCGR2B,FCGR3A,HSPA6,FCGR3B,FCRLA","- ",null,null,2212,null,null,"rs1801274-A","rs1801274",0,1801274,"missense",0,0.509,2e-38,37.698970004336,null,1.12,"[1.092-1.157] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V3 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Ulcerative colitis"," (up-regulated) to 12,924 European ancestry cases,  (up-regulated) to 21,442 European ancestry controls"," (up-regulated) to 25,683 European ancestry cases,  (up-regulated) to 17,015 European ancestry controls","4q24",4,103511114,"NFKB1,MANBA","- ",null,null,4790,null,null,"rs3774959-A","rs3774959",0,3774959,"intron",0,0.358,4e-12,11.397940008672,null,1.12,"[1.077-1.159] ","Affymetrix & Illumina [1.23 million] (imputed)","N"]
["V3 (up-regulated)","01/16/2013",23064961,"Shaffer JR","10/11/2012","J Dent Res","http://www.ncbi.nlm.nih.gov/pubmed/23064961","GWAS of dental caries patterns in the permanent dentition.","Dental caries","920 European ancestry individuals","NR","1p22.3",1,85226299,"LPAR3",null,117178,23566,null,70.06,52.79,"rs1750491-?","rs1750491",0,1750491,null,1,"NR",2e-06,5.69897000433601,"(LPAR3)","NR","NR","Illumina [518,997]","N"]
["V3 (up-regulated)","01/16/2013",23064961,"Shaffer JR","10/11/2012","J Dent Res","http://www.ncbi.nlm.nih.gov/pubmed/23064961","GWAS of dental caries patterns in the permanent dentition.","Dental caries","920 European ancestry individuals","NR","9q22.33",9,102234323,"TGFBR1, NR4A3",null,347265,8013,null,165.19,349.81,"rs649057-?","rs649057",0,649057,null,1,"NR",5e-06,5.30102999566398,"(DMFS5)","NR","NR","Illumina [518,997]","N"]
["V3 (up-regulated)","01/16/2013",23049088,"Meng W","10/09/2012","Invest Ophthalmol Vis Sci","http://www.ncbi.nlm.nih.gov/pubmed/23049088","A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.","Myopia (pathological)","187 European ancestry cases, 1064 European ancestry controls",null,"9p23",9,9924724,"PTPRD","- ",null,null,5789,null,null,"rs7849581-?","rs7849581",0,7849581,"intron",0,0.012,9e-07,6.04575749056067,null,"NR","NR","Affymetrix & Illumina [152,234]","N"]
["V3 (up-regulated)","12/21/2012",23042114,"Hirota T","10/07/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23042114","Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.","Atopic dermatitis","1,472 Japanese ancestry cases, 7,971 Japanese ancestry controls","1,856 Japanese ancestry cases, 7,021 Japanese ancestry controls","2q12.1",2,102971865,"IL1RL1, IL18R1, IL18RAP",null,9173,8809,null,3.37,7.23,"rs13015714-G","rs13015714",0,13015714,null,1,0.412,8e-18,17.096910013008,null,1.27,"[1.20-1.34] ","Illumina [606,164]","N"]
["V3 (up-regulated)","12/07/2012",23028483,"Ramasamy A","09/28/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23028483","Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.","Asthma","1,716 European ancestry cases, 16,888 European ancestry controls","4,035 European ancestry cases, 11,251 European ancestry controls","2q12.1",2,102955082,"IL1RL1, IL18R1","- ",null,null,9173,null,null,"rs13408661-G","rs13408661",0,13408661,"intron",0,0.84,1e-09,8.99999999999999,null,1.23,"[1.15-1.31] ","Affymetrix & Ilumina [~2.2 million] (imputed)","N"]
["V3 (up-regulated)","12/06/2012",23006423,"Niu N M D Ph D","09/24/2012","BMC Cancer","http://www.ncbi.nlm.nih.gov/pubmed/23006423 ","Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.","Response to taxane treatment (placlitaxel)","96 African American lymphoblastoid cell lines, 96 European ancestry lymphoblastoid cell lines, 96 Han Chinese lymphoblastoid cell lines","NR","11q24.1",11,121204601,"SC5DL ",null,6309,100533800,null,20.48,27.96,"rs4936613-? ","rs4936613 ",0,4936613,null,1,"NR",6e-06,5.22184874961635,null,"NR","NR","Affymetrix & Illumina [~1.3 million]","N"]
["V3 (up-regulated)","11/29/2012",23000144,"Nakamura M","09/18/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23000144","Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.","Primary biliary cirrhosis","487 Japanese ancestry cases, 476 Japanese ancestry controls","787 Japanese ancestry cases, 615 Japanese ancestry controls","4q23",4,99796784,"NFKB1",null,132556,1977,null,134.14,2.82,"rs7665590-G","rs7665590",0,7665590,null,1,"NR",1e-07,7,null,1.35,"[1.21-1.52] ","Affymetrix [421,245]","N"]
["V3 (up-regulated)","11/19/2012",22881374,"Cummings AC","09/01/2012","Ann Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/22881374","Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene.","Alzheimer's disease (late onset)","109 Amish cases, 689 Amish controls","NR","1q24.2",1,167718499,"MPZL1","- ",null,null,9019,null,null,"rs4145462-T","rs4145462",0,4145462,"intron",0,0.05,1e-06,5.99999999999999,null,"NR","NR","Affymetrix [614,963]","N"]
["V3 (up-regulated)","11/02/2012",22939635,"Reiner AP","08/28/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/22939635","Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.","C-reactive protein","8,280 African American women, 3,548 Hispanic/Latin American ancestry women","3,787 African American women, 3,548 Hispanic/Latin American ancestry women, 5,656 European ancestry individuals","2q13",2,113841030,"IL1F10, IL1RN",null,84639,3557,null,7.6,34.44,"rs6734238-G","rs6734238",0,6734238,null,1,0.446,9e-10,9.04575749056067,"(AA women)",0.11,"[0.073-0.143] unit decrease","Affymetrix [ (up-regulated) to 2,203,609] (imputed)","N"]
["V3 (up-regulated)","11/21/2012",22916037,"Inouye M","08/16/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22916037","Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.","Metabolite levels","6,608 European ancestry individuals","NR","8p23.1",8,9183596,"PPP1R3B, TNKS","- ",null,null,157273,null,null,"rs4841132-?","rs4841132",0,4841132,"ncRNA",0,0.15,2e-09,8.69897000433601,null,"NR","NR","Illumina [~2 million] (imputed)","N"]
["V3 (up-regulated)","11/21/2012",22916037,"Inouye M","08/16/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22916037","Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.","Metabolite levels","6,608 European ancestry individuals","NR","2q31.1",2,169763148,"G6PC2","- ",null,null,57818,null,null,"rs560887-?","rs560887",0,560887,"intron",0,0.31,4e-15,14.397940008672,null,"NR","NR","Illumina [~2 million] (imputed)","N"]
["V3 (up-regulated)","10/23/2012",22889924,"Scharf JM","08/14/2012","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22889924","Genome-wide association study of Tourette's syndrome.","Tourette syndrome","778 European ancestry cases, 4,414 European ancestry controls, 242 Ashkenazi Jewish cases, 354 Ashkenazi Jewish controls, 265 French Canadian cases, 196 French Canadian controls","211 Latin American ancestry cases, 285 Latin American ancestry controls","11q14.2",11,85783738,"PICALM",null,8301,283226,null,2.82,122.44,"rs621942-A","rs621942",0,621942,null,1,0.24,9e-06,5.04575749056067,null,1.22,"[NR] ","Illumina [484,295]","N"]
["V3 (up-regulated)","09/26/2012",22837378,"Wilk JB","07/26/2012","Am J Respir Crit Care Med","http://www.ncbi.nlm.nih.gov/pubmed/22837378","Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.","Airflow obstruction "," (up-regulated) to 3,368 European ancestry cases,  (up-regulated) to 29,507 European ancestry controls","331 European ancestry cases, 2,550 European ancestry controls","22q12.1",22,26653362,"SEZ6L","- ",null,null,23544,null,null,"rs1207393-?","rs1207393",0,1207393,"intron",0,0.64,5e-06,5.30102999566398,"(FEV1 65%)",1.19,null,"Affymetrix & Illumina [ (up-regulated) to ~2,500,000] (imputed)","N"]
["V3 (up-regulated)","09/26/2012",22837378,"Wilk JB","07/26/2012","Am J Respir Crit Care Med","http://www.ncbi.nlm.nih.gov/pubmed/22837378","Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.","Airflow obstruction "," (up-regulated) to 3,368 European ancestry cases,  (up-regulated) to 29,507 European ancestry controls","331 European ancestry cases, 2,550 European ancestry controls","9p23",9,9910123,"PTPRD","- ",null,null,5789,null,null,"rs10759102-?","rs10759102",0,10759102,"intron",0,0.67,1e-06,5.99999999999999,"(FEV1 65%)",1.23,"[NR] ","Affymetrix & Illumina [ (up-regulated) to ~2,500,000] (imputed)","N"]
["V3 (up-regulated)","09/18/2012",22797727,"Okada Y","07/15/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22797727","Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.","Renal function-related traits (BUN)","39,717 Japanese, Korean, and Chinese ancestry individuals","17,461 Japanese and Korean ancestry individuals","2q13",2,113978940,"PAX8","- ",null,null,7849,null,null,"rs11123170-G","rs11123170",0,11123170,"intron",0,0.35,3e-10,9.52287874528033,null,0.01,"[0.0035-0.0067] mg/dl increase","Affymetrix & Illumina [2,281,523] (imputed)","N"]
["V3 (up-regulated)","09/18/2012",22797727,"Okada Y","07/15/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22797727","Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.","Renal function-related traits (eGRFcrea)","42,451 Japanese, Chinese, Malay, and Indian ancestry individuals","19,636 Japanese, Chinese, and Korean ancestry individuals","16p12.3",16,20400839,"UMOD","- ",null,null,204474,null,null,"rs11864909-C","rs11864909",0,11864909,"intron",0,0.81,4e-10,9.39794000867203,null,0.01,"[0.0039-0.0075] ml/min/1.73m2 decrease","Affymetrix & Illumina [2,353,587] (imputed)","N"]
["V3 (up-regulated)","09/18/2012",22797727,"Okada Y","07/15/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22797727","Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.","Renal function-related traits (sCR)","42,257 Japanese, Chinese, Malay, and Indian ancestry individuals","19,662 Japanese, Chinese, and Korean ancestry individuals","16p12.3",16,20400839,"UMOD","- ",null,null,204474,null,null,"rs11864909-C","rs11864909",0,11864909,"intron",0,0.81,1e-10,10,null,0.01,"[0.0036-0.0068] mg/dl increase","Affymetrix & Illumina [2,353,587] (imputed)","N"]
["V3 (up-regulated)","08/15/2012",22703881,"Tang W","06/14/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/22703881","Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.","Activated partial thromboplastin time","9,240 European ancestry individuals","2611 European ancestry individuals","3q27.3",3,186390627,"AHSG, FETUB, HRG","- ",null,null,3273,null,null,"rs9898-C","rs9898",0,9898,"missense",0,"NR",1e-111,111,null,1,"[0.92-1.08] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","08/08/2012",22694956,"Cipriani V","06/13/2012","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/22694956","Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3.","Age-related macular degeneration","893 European ancestry cases, 2,199 European ancestry controls","1,411 European ancestry cases, 1,431 European ancestry controls","6p21.32",6,32171683,"NOTCH4","- ",null,null,4855,null,null,"rs2071277-C","rs2071277",0,2071277,"intron",0,0.219,2e-11,10.698970004336,null,1.3,"[1.20-1.41] ","Illumina [2,272,849] (imputed)","N"]
["V3 (up-regulated)","08/07/2012",22683712,"Freilinger T","06/10/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22683712","Genome-wide association analysis identifies susceptibility loci for migraine without aura.","Migraine","2,326 European ancestry cases, 4,580 European ancestry controls","2,508 European ancestry cases, 2,652 European ancestry controls","9q33.1",9,119252629,"ASTN2","- ",null,null,23245,null,null,"rs6478241-A","rs6478241",0,6478241,"intron",0,0.38,4e-08,7.39794000867203,null,1.16,"[1.10-1.23] ","Illumina [1,246,388] (imputed)","N"]
["V3 (up-regulated)","07/17/2012",22658931,"Pajewski NM","05/30/2012","Vaccine","http://www.ncbi.nlm.nih.gov/pubmed/22658931","A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed.","Immune response to anthrax vaccine ","726 European ancestry individuals","NR","9q33.1",9,119925095,"ASTN2","- ",null,null,23245,null,null,"rs6478282-A","rs6478282",0,6478282,"intron",0,"NR",6e-06,5.22184874961635,null,0.1,"[0.058-0.144] unit increase","Affymetrix [736,996]","N"]
["V3 (up-regulated)","08/07/2012",22610502,"Kennedy RB","05/19/2012","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/22610502","Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.","Immune reponse to smallpox (secreted IL-2)"," (up-regulated) to 512 European ancestry individuals,  (up-regulated) to 199 African American individuals","NR","3p21.1",3,52844534,"ITIH3, ITIH4",null,3699,3700,null,1.51,2.47,"rs17331151-A","rs17331151",0,17331151,null,1,"NR",2e-09,8.69897000433601,"(AA)","NR","NR","Illumina [NR]","N"]
["V3 (up-regulated)","08/14/2012",22832961,"Kamboh MI","05/15/2012","Transl Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22832961","Genome-wide association study of Alzheimer's disease.","Alzheimer's disease","1,291 European ancestry cases, 938 European ancestry controls","2,727 cases, 3,336 controls","11q14.2",11,85677471,"PICALM","- ",null,null,8301,null,null,"rs17817600-?","rs17817600",0,17817600,"intron",0,"NR",2e-08,7.69897000433601,null,1.33,"[NR] ","Illumina [2,543,888] (imputed)","N"]
["V3 (up-regulated)","07/31/2012",22745009,"Melville SA","05/15/2012","Ann Neurol","http://www.ncbi.nlm.nih.gov/pubmed/22745009","Multiple loci influencing hippocampal degeneration identified by genome scan.","Hippocampal atrophy","1149 European ancestry Alzheimer disease cases, 336 European ancestry individuals with mild cognitive impairment, 188 European ancestry controls","419 African American Alzheimer disease cases","1p32.3",1,53581670,"SLC1A7","- ",null,null,6512,null,null,"rs3820201-A","rs3820201",0,3820201,"intron",0,0.62,1e-06,5.99999999999999,"(Hippocampal volume)","NR","NR","Illumina [2,131,250] (imputed)","N"]
["V3 (up-regulated)","08/14/2012",22832960,"Service SK","05/15/2012","Transl Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22832960","A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.","Temperament"," (up-regulated) to 12,433 individuals","NR","2p16.3",2,50731318,"NRXN1","- ",null,null,9378,null,null,"rs6754640-A","rs6754640",0,6754640,"intron",0,0.452,1e-06,5.99999999999999,"(Novelty seeking)",0.15,"unit decrease","Affymetrix & Illumina [1,252,222] (imputed)","N"]
["V3 (up-regulated)","08/14/2012",22832960,"Service SK","05/15/2012","Transl Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22832960","A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.","Temperament"," (up-regulated) to 12,433 individuals","NR","9p23",9,10043014,"PTPRD","- ",null,null,5789,null,null,"rs291272-T","rs291272",0,291272,"intron",0,0.965,5e-06,5.30102999566398,"(Persistence)",0.2,"unit decrease","Affymetrix & Illumina [1,252,222] (imputed)","N"]
["V3 (up-regulated)","08/15/2012",22581228,"Manning AK","05/13/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22581228","A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.","Fasting glucose-related traits (interaction with BMI)"," (up-regulated) to 58,074 European ancestry individuals"," (up-regulated) tp 38,422 European ancestry individuals","2q31.1",2,169763148,"G6PC2","- ",null,null,57818,null,null,"rs560887-?","rs560887",0,560887,"intron",0,"NR",2e-113,112.698970004336,null,"NR","NR","Affymetrix & Illumina [~2.4 million] (imputed)","N"]
["V3 (up-regulated)","08/17/2012",22589738,"Fox CS","05/10/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22589738","Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.","Subcutaneous adipose tissue","5,560 European ancestry women and 4,997 European ancestry men","NR","5q35.2",5,173695778,"HMP19",null,51617,2613,null,159.6,244.46,"rs11952171-A","rs11952171",0,11952171,null,1,0.18,7e-06,5.15490195998574,"(women)","NR","NR","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V3 (up-regulated)","08/17/2012",22589738,"Fox CS","05/10/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22589738","Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.","Visceral adipose tissue/subcutaneous adipose tissue ratio","5,560 European ancestry women and 4,997 European ancestry men","NR","10q26.3",10,135306158,"CYP2E1",null,81352,1571,null,10.88,34.71,"rs1536827-C","rs1536827",0,1536827,null,1,0.07,4e-06,5.39794000867203,"(men)","NR","NR","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V3 (up-regulated)","08/17/2012",22589738,"Fox CS","05/10/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22589738","Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.","Visceral adipose tissue/subcutaneous adipose tissue ratio","5,560 European ancestry women and 4,997 European ancestry men","NR","11q22.3",11,106496038,"GUCY1A2",null,60496,2977,null,526.62,48.7,"rs1791581-A","rs1791581",0,1791581,null,1,0.17,8e-06,5.09691001300805,"(men)","NR","NR","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V3 (up-regulated)","08/17/2012",22589738,"Fox CS","05/10/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22589738","Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.","Visceral adipose tissue/subcutaneous adipose tissue ratio","5,560 European ancestry women and 4,997 European ancestry men","NR","4q35.1",4,186612675,"SORBS2","- ",null,null,8470,null,null,"rs4376189-A","rs4376189",0,4376189,"intron",0,0.9,2e-06,5.69897000433601,"(overall)","NR","NR","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V3 (up-regulated)","08/17/2012",22589738,"Fox CS","05/10/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22589738","Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.","Visceral fat","5,560 European ancestry women and 4,997 European ancestry men","NR","21q21.3",21,30713598,"BACH1","- ",null,null,571,null,null,"rs17744121-G","rs17744121",0,17744121,"intron",0,0.07,6e-06,5.22184874961635,"(men)","NR","NR","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V3 (up-regulated)","08/14/2012",22566634,"Benjamin DJ","05/07/2012","Proc Natl Acad Sci U S A","http://www.ncbi.nlm.nih.gov/pubmed/22566634","The genetic architecture of economic and political preferences.","Economic and political preferences (fairness)","9,617 individuals","NR","9q33.1",9,120137758,"ASTN2","- ",null,null,23245,null,null,"rs2226006-T","rs2226006",0,2226006,"intron",0,"NR",6e-06,5.22184874961635,null,0.11,"[0.062-0.160] unit decrease","Illumina [628,922]","N"]
["V3 (up-regulated)","08/14/2012",22566634,"Benjamin DJ","05/07/2012","Proc Natl Acad Sci U S A","http://www.ncbi.nlm.nih.gov/pubmed/22566634","The genetic architecture of economic and political preferences.","Economic and political preferences (feminism/equality)","9,617 individuals","NR","11q14.1",11,82723072,"RAB30","- ",null,null,27314,null,null,"rs11233413-T","rs11233413",0,11233413,"intron",0,"NR",4e-07,6.39794000867203,null,0.11,"[0.067-0.149] unit decrease","Illumina [628,922]","N"]
["V3 (up-regulated)","07/04/2012",22542470,"Ovsyannikova IG","04/25/2012","Vaccine","http://www.ncbi.nlm.nih.gov/pubmed/22542470","Genome-wide association study of antibody response to smallpox vaccine.","Immune response to smallpox vaccine (IL-6)","217 African American ancestry individuals, 580 European ancestry individuals, 217 Hispanic ancestry individuals","NR","10q23.33",10,96766934,"CYP2C9",null,1559,100874505,null,17.79,0.22,"rs2860975-?","rs2860975",0,2860975,null,1,"NR",2e-07,6.69897000433601,"(Hispanic)","NR","NR","Illumina [NR]","N"]
["V3 (up-regulated)","06/19/2012",22508271,"Rasmussen-Torvik LJ","04/16/2012","Genet Epidemiol","http://www.ncbi.nlm.nih.gov/pubmed/22508271","Fasting glucose GWAS candidate region analysis across ethnic gro (up-regulated)s in the Multiethnic Study of Atherosclerosis (MESA).","Fasting plasma glucose","2,349 European ancestry individuals, 664 Chinese ancestry individuals, 1,366 African American individuals, 1,171 Hispanic ancestry individuals","NR","2q31.1",2,169763148,"G6PC2","- ",null,null,57818,null,null,"rs560887-T","rs560887",0,560887,"intron",0,0.2,2e-06,5.69897000433601,"(fasting glucose)",1.29,"[0.84-1.74] mg/dL decrease","Affymetrix [NR] (imputed)","N"]
["V3 (up-regulated)","06/02/2012",22504421,"Bis JC","04/15/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22504421","Common variants at 12q14 and 12q24 are associated with hippocampal volume.","Hippocampal volume","9,232 European ancestry individuals","2,318 European ancestry individuals","9q33.1",9,119249339,"ASTN2","- ",null,null,23245,null,null,"rs7852872-C","rs7852872",0,7852872,"intron",0,0.62,1e-07,7,null,47.7,"[30.06-65.34] mm3 decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","05/11/2012",22472876,"Major Depressive Disorder Working Gro (up-regulated) of the Psychiatric GWAS Consortium","04/03/2012","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22472876","A mega-analysis of genome-wide association studies for major depressive disorder.","Major depressive disorder","9,240 European ancestry cases, 9,519 European ancestry controls","6,783 European ancestry cases, 50,695 European ancestry controls","16q24.2",16,87461969,"FBXO31,MAP1LC3B,ZCCHC14","- ",null,null,23174,null,null,"rs9646303-?","rs9646303",0,9646303,"intron",0,"NR",5e-06,5.30102999566398,null,"NR","NR","Affymetrix, Illumina & Perlegen [~1.2 million](imputed)","N"]
["V3 (up-regulated)","04/24/2012",22479419,"Liou YJ","03/27/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/22479419","Genome-wide association study of treatment refractory schizophrenia in Han Chinese.","Schizophrenia (treatment refractory) ","522 Han Chinese cases, 806 Han Chinese controls","273 Han Chinese cases","4q24",4,103457418,"NFKB1","- ",null,null,4790,null,null,"rs230529-T","rs230529",0,230529,"intron",0,0.47,2e-07,6.69897000433601,null,1.45,"[1.26-1.66] ","Affymetrix [694,436]","N"]
["V3 (up-regulated)","04/03/2012",22399527,"Kristiansson K","03/07/2012","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/22399527","Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.","Metabolic syndrome","2,637 European ancestry cases, 7,927 European ancestry controls","NR","2q31.1",2,169763148,"G6PC2","- ",null,null,57818,null,null,"rs560887-G","rs560887",0,560887,"intron",0,0.69,5e-26,25.3010299956639,"(GLU)",0.15,"[NR] mmol/l increase","Illumina [1,257,079] (imputed)","N"]
["V3 (up-regulated)","03/23/2012",22344221,"Okada Y","02/19/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22344221","Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.","Body mass index","26,620 Japanese ancestry individuals","7,910 Japanese ancestry individuals, 27,715 East Asian individuals","11p14.1",11,27728539,"BDNF","- ",null,null,627,null,null,"rs2030323-C","rs2030323",0,2030323,"intron",0,0.6,4e-16,15.397940008672,null,0.05,"[0.034-0.058] unit increase","Illumina [2,178,018] (imputed)","N"]
["V3 (up-regulated)","03/27/2012",22359512,"Demirkan A","02/16/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22359512","Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.","Phospholipid levels (plasma)","4,034 European ancestry individuals","NR","13q22.1",13,75128114,"KLF12","- ",null,null,338864,null,null,"rs17718828-?","rs17718828",0,17718828,"intron",0,"NR",1e-08,8,"(levels)",0.8,"[NR] % increase","Illumina [NR] (imputed)","N"]
["V3 (up-regulated)","02/28/2012",22286219,"Kettunen J","01/29/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22286219","Genome-wide association study identifies multiple loci influencing human serum metabolite levels.","Lipid metabolism phenotypes","8,330 European ancestry individuals","NR","1q23.3",1,161540857,"FCGR2B, FCGR2A",null,2214,3311,null,20.44,34.99,"rs67418890-?","rs67418890",0,67418890,null,1,"NR",1e-10,10,"(XL-HDL-CE)",0.19,"[0.13-0.25] unit increase","Illumina [~7.7 million] (imputed)","N"]
["V3 (up-regulated)","02/28/2012",22286219,"Kettunen J","01/29/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22286219","Genome-wide association study identifies multiple loci influencing human serum metabolite levels.","Metabolite levels","8,330 European ancestry individuals","NR","2q31.1",2,169763148,"G6PC2","- ",null,null,57818,null,null,"rs560887-?","rs560887",0,560887,"intron",0,"NR",2e-17,16.698970004336,"(Glc)",0.15,"[0.11-0.19] unit increase","Illumina [~7.7 million] (imputed)","N"]
["V3 (up-regulated)","03/10/2012",22228203,"Aslibekyan S","01/05/2012","Pharmacogenet Genomics","http://www.ncbi.nlm.nih.gov/pubmed/22228203","A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network.","Inflammatory biomarkers","1,092 European ancestry individuals","NR","14q13.1",14,33586563,"NPAS3","- ",null,null,64067,null,null,"rs17460823-?","rs17460823",0,17460823,"intron",0,"NR",2e-06,5.69897000433601,"(C-reactive protein)","NR","NR","Affymetrix [2,543,887](imputed)","N"]
["V3 (up-regulated)","01/19/2012",22197933,"Hu Z","12/25/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22197933","A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.","Non-obstructive azoospermia","981 Chinese ancestry cases, 1,657 Chinese ancestry controls.","1,946 Chinese ancestry cases, 4,077 Chinese ancestry controls.","12p12.1",12,24184544,"SOX5","- ",null,null,6660,null,null,"rs10842262-?","rs10842262",0,10842262,"intron",0,"NR",2e-09,8.69897000433601,null,1.23,"[1.15-1.32] ","Affymetrix [587,347]","N"]
["V3 (up-regulated)","01/27/2012",22182935,"Chen DT","12/20/2011","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22182935","Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.","Bipolar disorder","5,568 European ancestry cases, 7,187 European ancestry controls, 1,000 Taiwanese cases, 1,000 Taiwanese controls","1,115 European ancestry cases, 2,728 European ancestry controls","10q21.2",10,62185494,"ANK3","- ",null,null,288,null,null,"rs4948418-T","rs4948418",0,4948418,"intron",0,"NR",4e-10,9.39794000867203,null,"NR","NR","Affymetrix & Illumina [748,555]","N"]
["V3 (up-regulated)","01/31/2012",22174851,"Lingappa JR","12/12/2011","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/22174851","Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant co (up-regulated)les with quantified virus exposure.","HIV-1 viral setpoint","798 African ancestry individuals","NR","6p22.2",6,26031613,"HIST1H4A","- ",null,null,8358,null,null,"rs10484434-?","rs10484434",0,10484434,"nearGene-3",0,"NR",1e-06,5.99999999999999,null,"NR","NR","Illumina [990,115]","N"]
["V3 (up-regulated)","01/18/2012",22158540,"Wu C","12/11/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22158540","Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.","Pancreatic cancer","981 Chinese ancestry cases, 1,991 Chinese ancestry contorls.","2,603 Chinese ancestry cases, 2,877 Chinese ancestry controls.","21q21.3",21,30717737,"BACH1","- ",null,null,571,null,null,"rs372883-T","rs372883",0,372883,"intron",0,"NR",2e-13,12.698970004336,null,1.27,"[1.19-1.33] ","Affymetrix [666,141]","N"]
["V3 (up-regulated)","01/06/2012",22142827,"Innocenti F","12/05/2011","Clin Cancer Res","http://www.ncbi.nlm.nih.gov/pubmed/22142827","A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.","Response to gemcitabine in pancreatic cancer ","294 European ancestry cases","NR","12p13.2",12,11547532,"PRB2","- ",null,null,653247,null,null,"rs2900174-G","rs2900174",0,2900174,"intron",0,"NR",1e-06,5.99999999999999,null,3.3,"[2.00-5.50] ","Illumina [330,690]","N"]
["V3 (up-regulated)","11/16/2012",22139419,"Gieger C","11/30/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/22139419","New gene functions in megakaryopoiesis and platelet formation.","Platelet counts","48,666 individuals of European ancestry"," (up-regulated) to 18,838 individuals of European ancestry","17q21.31",17,42442344,"FAM171A2,ITGA2B","- ",null,null,284069,null,null,"rs708382-T","rs708382",0,708382,"nearGene-5",0,"NR",2e-08,7.69897000433601,null,2.44,"[1.59-3.28] 10^9/l increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","12/14/2011",22087292,"Sun L","11/07/2011","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/22087292","Bivariate genome-wide association analyses of femoral neck bone geometry and appendicular lean mass.","Femoral neck bone geometry","1,627 Han Chinese individuals","2,286 European ancestry individuals","16p12.3",16,20351231,"UMOD","- ",null,null,7369,null,null,"rs11859916-?","rs11859916",0,11859916,"intron",0,"NR",2e-06,5.69897000433601,"(ALM-W)","NR","NR","Affymetrix [689,368]","N"]
["V3 (up-regulated)","12/01/2011",22036096,"Ramasamy A","11/01/2011","J Allergy Clin Immunol","http://www.ncbi.nlm.nih.gov/pubmed/22036096","A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.","Allergic rhinitis","3,933 European ancestry cases, 8,965 European ancestry controls","NR","5q23.1",5,115975656,"SEMA6A",null,644146,6219,null,76.9,76.26,"rs6898653-G","rs6898653",0,6898653,null,1,0.22,1e-06,5.99999999999999,null,1.23,"[1.13-1.34] ","Affymetrix & Illumina  [2,217,510] (imputed)","N"]
["V3 (up-regulated)","11/19/2011",22005931,"Kamboh MI","10/18/2011","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22005931","Genome-wide association analysis of age-at-onset in Alzheimer's disease.","Alzheimer's disease (age of onset)","2,222 cases","NR","15q25.3",15,85430969,"SLC28A1, ZNF592, ALPK3","- ",null,null,9154,null,null,"rs3743162-?","rs3743162",0,3743162,"intron",0,"NR",9e-06,5.04575749056067,null,"NR","NR","Illumina [2,543,888] (imputed)","N"]
["V3 (up-regulated)","11/18/2011",22001757,"Chambers JC","10/16/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22001757","Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.","Liver enzyme levels (gamma-glutamyl transferase)"," (up-regulated) to 52,350 European ancestry individuals,  (up-regulated) to 8,739 Indian Asian individuals","NR","1p36.13",1,16505320,"RSG1, EPHA2",null,1969,128272,null,22.74,19.28,"rs1497406-G","rs1497406",0,1497406,null,1,0.56,3e-19,18.5228787452803,null,3.8,"[2.70-4.80] % increase","Affymetrix, Illumina, and Perlegen [~2.6 million] (imputed)","N"]
["V3 (up-regulated)","12/10/2011",21983787,"Barrett JH","10/09/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21983787","Genome-wide association study identifies three new melanoma susceptibility loci.","Melanoma","2,804 European ancestry cases, 7,618 European ancestry controls","5,551 European ancestry cases, 7,449 European ancestry controls","9p21.3",9,21816528,"CDKN2A, MTAP","- ",null,null,4507,null,null,"rs7023329-?","rs7023329",0,7023329,"intron",0,0.51,7e-09,8.15490195998574,null,1.2,"[1.14-1.28] ","Illumina [594,997]","N"]
["V3 (up-regulated)","10/17/2011",21926974,"Ripke S","09/18/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21926974","Genome-wide association study identifies five new schizophrenia loci.","Schizophrenia","9,394 European ancestry cases, 12,462 European ancestry controls","8,442 European ancestry cases, 21,397 European ancestry controls","3p21.1",3,52855229,"ITIH3, ITIH4","- ",null,null,3700,null,null,"rs2239547-?","rs2239547",0,2239547,"intron",0,"NR",6e-08,7.22184874961635,null,1.1,"[1.06-1.14] ","Affymetrix & Illumina [1,252,901] (imputed)","N"]
["V3 (up-regulated)","10/19/2011",21926972,"Sklar P","09/18/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21926972","Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.","Bipolar disorder","7,481 European ancestry cases, 9,250 European ancestry controls","4,496 European ancestry cases, 42,422 European ancestry controls","3p21.1",3,52835354,"WDR82, TWF2, TNNC1, TMEM110, TLR9, STAB1,SPCS1, SNORD69, SNORD19, SNORD19B, SFMBT1, SEMA3G, RFT1, PRKCD, PPM1M, PHF7, PBRM1, NT5DC2, NISCH, NEK4, MUSTN1, LOC440957, ITIH1, ITIH3, ITIH4, GNL3, GLYCTK, GLT8D1, DNAH1, BAP1, ALAS1","- ",null,null,3699,null,null,"rs736408-C","rs736408",0,736408,"intron",0,"NR",2e-06,5.69897000433601,null,1.1,"[NR] ","Affymetrix & Illumina [2,415,422] (imputed)","N"]
["V3 (up-regulated)","10/19/2011",21926972,"Sklar P","09/18/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21926972","Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.","Bipolar disorder","7,481 European ancestry cases, 9,250 European ancestry controls","4,496 European ancestry cases, 42,422 European ancestry controls","10q21.2",10,62279124,"ANK3","- ",null,null,288,null,null,"rs10994397-T","rs10994397",0,10994397,"intron",0,"NR",3e-07,6.52287874528033,null,1.22,"[NR] ","Affymetrix & Illumina [2,415,422] (imputed)","N"]
["V3 (up-regulated)","10/21/2011",21909115,"Ehret GB","09/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21909115","Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.","Diastolic blood pressure","69,395 European ancestry individuals"," (up-regulated) to 133,361 European ancestry individuals","4q32.1",4,156645513,"GUCY1A3, GUCY1B3","- ",null,null,2982,null,null,"rs13139571-C","rs13139571",0,13139571,"intron",0,0.76,2e-10,9.69897000433601,null,0.26,"[NR] mmHg increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","10/21/2011",21909115,"Ehret GB","09/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21909115","Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.","Systolic blood pressure","69,395 European ancestry individuals"," (up-regulated) to 133,361 European ancestry individuals","4q32.1",4,156645513,"GUCY1A3, GUCY1B3","- ",null,null,2982,null,null,"rs13139571-C","rs13139571",0,13139571,"intron",0,0.76,1e-06,5.99999999999999,null,0.32,"[NR] mmHg increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","10/11/2011",21909110,"Wain LV","09/11/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21909110","Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.","Blood pressure","74,064 European ancestry individuals","48,607 European ancestry individuals","4q32.1",4,156645513,"GUCY1A3, GUCY1B3","- ",null,null,2982,null,null,"rs13139571-C","rs13139571",0,13139571,"intron",0,0.74,3e-07,6.52287874528033,"(Mean Arterial Pressure)",0.29,"[0.18-0.40] mmHg increase","Affymetrix, Illumina, and Perlegen [NR] (imputed)","N"]
["V3 (up-regulated)","09/30/2011",21907864,"Ferreira MA","09/10/2011","Lancet","http://www.ncbi.nlm.nih.gov/pubmed/21907864","Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.","Asthma","12,475 European ancestry cases, 19,967 European ancestry controls","3,322 European ancestry cases, 22,036 European ancestry controls","1q21.3",1,154426264,"IL6R","- ",null,null,3570,null,null,"rs4129267-T","rs4129267",0,4129267,"intron",0,0.37,2e-08,7.69897000433601,null,1.09,"[1.06-1.12] ","Illumina [NR] (imputed)","N"]
["V3 (up-regulated)","09/27/2011",21901158,"Irvin MR","08/25/2011","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/21901158","Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study.","Insulin resistance/response","1,040 non-diabetic individuals","NR","22q12.1",22,26697195,"SEZ6L","- ",null,null,23544,null,null,"rs591044-A","rs591044",0,591044,"intron",0,0.37,6e-06,5.22184874961635,"(Insulin)",9,"[5.00 - 13.00] % increase","Affymetrix [872,243]","N"]
["V3 (up-regulated)","10/24/2012",21833088,"Sawcer S","08/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21833088","Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.","Multiple sclerosis","9,772 European ancestry cases, 16,849 European ancestry controls","4,218 European ancestry cases, 7,296 European ancestry controls","4q24",4,103578637,"MANBA, NFKB1","- ",null,null,4126,null,null,"rs228614-G","rs228614",0,228614,"intron",0,"NR",1e-07,7,null,1.09,"[1.07-1.1] ","Illumina [465,434]","N"]
["V3 (up-regulated)","10/24/2012",21833088,"Sawcer S","08/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21833088","Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.","Multiple sclerosis","9,772 European ancestry cases, 16,849 European ancestry controls","4,218 European ancestry cases, 7,296 European ancestry controls","12q14.1",12,58133256,"AGAP2, CYP27B1","- ",null,null,116986,null,null,"rs12368653-A","rs12368653",0,12368653,"intron",0,"NR",2e-09,8.69897000433601,"(Conditioned on rs7238078)",1.1,"[1.09-1.12] ","Illumina [465,434]","N"]
["V3 (up-regulated)","08/27/2011",21804548,"Hirota T","07/31/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21804548","Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.","Asthma","1,532 Japanese ancestry cases, 3,304 Japanese ancestry controls","5,639 Japanese ancestry cases, 24,608 Japanese ancestry controls","6p21.32",6,32184345,"NOTCH4","- ",null,null,4855,null,null,"rs404860-A","rs404860",0,404860,"intron",0,0.5,4e-23,22.397940008672,null,1.21,"[1.16-1.25] ","Illumina [458,847]","N"]
["V3 (up-regulated)","08/20/2011",21804549,"Torgerson DG","07/31/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21804549","Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.","Asthma","2,088 European American cases, 1,612 African American and African Caribbean cases, 1,688 Hispanic ancestry cases","2,727 European American cases, 2,147 African American and African Caribbean cases, 2,299 Hispanic ancestry cases","2q12.1",2,102953617,"IL1RL1","- ",null,null,9173,null,null,"rs3771180-?","rs3771180",0,3771180,"intron",0,"NR",2e-15,14.698970004336,null,"NR","NR","Affymetrix & Illumina [>2 million] (imputed)","N"]
["V3 (up-regulated)","08/12/2011",21779181,"Gorlova O","07/14/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21779181","Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.","Systemic sclerosis","2,296 European ancestry cases, 5,172 European ancestry controls","3,175 European ancestry cases, 4,210 European ancestry controls","6p21.32",6,32190406,"NOTCH4","- ",null,null,4855,null,null,"rs443198-?","rs443198",0,443198,"cds-synon",0,0.63,9e-21,20.0457574905606,"(ACA positive)",1.82,"[1.59-2.04] ","Illumina [NR] (imputed)","N"]
["V3 (up-regulated)","08/12/2011",21779181,"Gorlova O","07/14/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21779181","Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.","Systemic sclerosis","2,296 European ancestry cases, 5,172 European ancestry controls","3,175 European ancestry cases, 4,210 European ancestry controls","12p12.1",12,23946146,"SOX5","- ",null,null,6660,null,null,"rs11047102-?","rs11047102",0,11047102,"intron",0,0.1,1e-07,7,"(ACA positive)",1.36,"[1.21-1.52] ","Illumina [NR] (imputed)","N"]
["V3 (up-regulated)","08/12/2011",21779181,"Gorlova O","07/14/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21779181","Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.","Systemic sclerosis","2,296 European ancestry cases, 5,172 European ancestry controls","3,175 European ancestry cases, 4,210 European ancestry controls","6p21.32",6,32218989,"NOTCH4",null,4855,100131609,null,27.15,74.19,"rs9296015-?","rs9296015",0,9296015,null,1,0.81,1e-08,8,"(ATA positive)",1.85,"[1.49-2.27] ","Illumina [NR] (imputed)","N"]
["V3 (up-regulated)","08/12/2011",21779181,"Gorlova O","07/14/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21779181","Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.","Systemic sclerosis","2,296 European ancestry cases, 5,172 European ancestry controls","3,175 European ancestry cases, 4,210 European ancestry controls","12p12.1",12,23946146,"SOX5","- ",null,null,6660,null,null,"rs11047102-?","rs11047102",0,11047102,"intron",0,0.1,5e-06,5.30102999566398,"(IcSSc)",1.24,"[1.13-1.35] ","Illumina [NR] (imputed)","N"]
["V3 (up-regulated)","08/15/2011",21779176,"Winkelmann J","07/14/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21779176","Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.","Restless legs syndrome","922 European ancestry cases, 1,526 European ancestry controls","3,935 European ancestry cases, 5,754 European ancestry controls","9p24.1",9,8846955,"PTPRD","- ",null,null,5789,null,null,"rs1975197-A","rs1975197",0,1975197,"intron",0,0.16,3e-10,9.52287874528033,null,1.29,"[1.19-1.40] ","Affymetrix [301,406]","N"]
["V3 (up-regulated)","07/19/2011",21708048,"Jiao H","06/28/2011","BMC Med Genomics","http://www.ncbi.nlm.nih.gov/pubmed/21708048","Genome wide association study identifies KCNMA1 contributing to human obesity.","Obesity","164 morbidly obese European ancestry individuals, 163 lean European ancestry individuals","4,674 morbidly obese European ancestry individuals, 5,663 lean European ancestry individuals","11p14.1",11,27563382,"BDNF","- ",null,null,497258,null,null,"rs988712-G","rs988712",0,988712,"intron",0,0.75,5e-17,16.3010299956639,null,1.36,"[1.20-1.55] ","Affymetrix [406,177]","N"]
["V3 (up-regulated)","07/14/2011",21685912,"Hoglinger GU","06/19/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21685912","Identification of common variants influencing risk of the tauopathy progressive s (up-regulated)ranuclear palsy.","Progressive s (up-regulated)ranuclear palsy","1,114 cases, 3,287 controls","1,051 European ancestry cases, 3,560 European ancestry controls","6p25.3",6,396321,"IRF4","- ",null,null,3662,null,null,"rs12203592-?","rs12203592",0,12203592,"intron",0,0.19,6e-15,14.2218487496163,null,1.48,"[1.34-1.63] ","Illumina [531,451]","N"]
["V3 (up-regulated)","07/14/2011",21685912,"Hoglinger GU","06/19/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21685912","Identification of common variants influencing risk of the tauopathy progressive s (up-regulated)ranuclear palsy.","Progressive s (up-regulated)ranuclear palsy","1,114 cases, 3,287 controls","1,051 European ancestry cases, 3,560 European ancestry controls","3p22.1",3,39523003,"MOBP","- ",null,null,4336,null,null,"rs1768208-?","rs1768208",0,1768208,"intron",0,0.71,5e-17,16.3010299956639,null,1.37,"[1.28-1.49] ","Illumina [531,451]","N"]
["V3 (up-regulated)","06/18/2011",21647700,"Below JE","06/07/2011","Diabetologia","http://www.ncbi.nlm.nih.gov/pubmed/21647700","Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.","Type 2 diabetes","837 Mexican-American cases, 781 Mexican-American controls","967 Hispanic cases, 343 Hispanic controls","9p23",9,10430602,"PTPRD","- ",null,null,5789,null,null,"rs649891-C","rs649891",0,649891,"intron",0,0.35,6e-06,5.22184874961635,null,"NR","NR","Affymetrix [1,829,586] (imputed)","N"]
["V3 (up-regulated)","06/23/2011",21627779,"Antunez C","05/31/2011","Genome Med","http://www.ncbi.nlm.nih.gov/pubmed/21627779","The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease.","Alzheimer's disease","319 European ancestry cases, 769 European ancestry controls, 2,690 cases, 2,237 controls","7,172 European ancestry cases, 11,335 European ancestry controls","11q14.2",11,85787824,"PICALM",null,8301,283226,null,6.9,118.35,"rs536841-?","rs536841",0,536841,null,1,"NR",3e-09,8.52287874528033,null,1.16,"[NR] ","Affymetrix and Illumina [696,707](imputed)","N"]
["V3 (up-regulated)","06/04/2011",21606135,"Wild PS","05/23/2011","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/21606135","A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease.","Coronary heart disease","2,078 European descent cases, 2,953 European descent controls","19,350 European descent cases, 35,408 European descent controls","9p21.3",9,22031005,"MTAP","- ",null,null,100048912,null,null,"rs7865618-A","rs7865618",0,7865618,"intron",0,0.59,2e-27,26.698970004336,null,1.18,"[1.14-1.21] ","Affymetrix [608,247]","N"]
["V3 (up-regulated)","05/27/2011",21546767,"Murea M","05/05/2011","Am J Nephrol","http://www.ncbi.nlm.nih.gov/pubmed/21546767","Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.","Dialysis-related mortality","610 African American type 2 diabetics","NR","1q41",1,217527024,"GPATCH2, ESRRG",null,2104,55105,null,215.93,76.81,"rs1497828-?","rs1497828",0,1497828,null,1,0.63,4e-06,5.39794000867203,null,1.41,"[1.22-1.64] ","Affymetrix [832,357]","N"]
["V3 (up-regulated)","05/27/2011",21546767,"Murea M","05/05/2011","Am J Nephrol","http://www.ncbi.nlm.nih.gov/pubmed/21546767","Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.","Dialysis-related mortality","610 African American type 2 diabetics","NR","20p12.1",20,17357573,"PCSK2","- ",null,null,5126,null,null,"rs4814615-?","rs4814615",0,4814615,"intron",0,0.19,5e-06,5.30102999566398,null,1.59,"[1.30-1.95] ","Affymetrix [832,357]","N"]
["V3 (up-regulated)","05/26/2011",21533175,"Zhai G","04/14/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21533175","Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.","Dehydroepiandrosterone sulphate levels","14,846 European ancestry individuals","NR","10q23.33",10,96751270,"CYP2C9",null,1559,100874505,null,2.12,15.89,"rs2185570-C","rs2185570",0,2185570,null,1,0.13,2e-08,7.69897000433601,null,0.06,"[0.04-0.08] u mol/L decrease","Affymetrix & Illumina [~2.5 million](imputed)","N"]
["V3 (up-regulated)","05/24/2011",21460841,"Naj AC","04/03/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21460841","Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.","Alzheimer's disease (late onset)","8,309 European ancestry cases, 7,366 European ancestry controls","10,523 European ancestry cases, 28,231 European ancestry controls","11q14.2",11,85800279,"PICALM",null,8301,283226,null,19.36,105.89,"rs561655-?","rs561655",0,561655,null,1,0.66,7e-11,10.1549019599857,null,1.15,"[1.10-1.19] ","Affymetrix & Illumina [2,324,889] (imputed)","N"]
["V3 (up-regulated)","04/12/2011",21399635,"Mells GF","03/13/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21399635","Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.","Primary biliary cirrhosis","2,774 European ancestry cases, 9,814 European ancestry controls","620 European ancestry cases, 2,514 European ancestry controls","4q24",4,103551603,"NFKB1",null,4790,100271166,null,13.14,32.14,"rs7665090-C","rs7665090",0,7665090,null,1,0.52,4e-12,11.397940008672,null,1.26,"[1.18-1.34] ","Illumina [507,467]","N"]
["V3 (up-regulated)","04/07/2011",21408207,"Chung SA","03/03/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21408207","Differential genetic associations for systemic l (up-regulated)us erythematosus based on anti-dsDNA autoantibody production.","Systemic l (up-regulated)us erythematosus","811 anti-dsDNA positive European ancestry cases, 906 anti-dsDNA negative European ancestry cases, 4,813 European ancestry controls","NR","1p32.3",1,53629585,"SLC1A7",null,6512,1376,null,21.3,32.52,"rs6695567-?","rs6695567",0,6695567,null,1,0.57,4e-06,5.39794000867203,"(anti-dsDNA +)",1.32,"[1.18-1.47] ","Illumina [421,318] (imputed)","N"]
["V3 (up-regulated)","04/07/2011",21408207,"Chung SA","03/03/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21408207","Differential genetic associations for systemic l (up-regulated)us erythematosus based on anti-dsDNA autoantibody production.","Systemic l (up-regulated)us erythematosus","811 anti-dsDNA positive European ancestry cases, 906 anti-dsDNA negative European ancestry cases, 4,813 European ancestry controls","NR","6p21.32",6,32223258,"NOTCH4, C6orf10",null,4855,100131609,null,31.41,69.92,"rs3130320-T","rs3130320",0,3130320,null,1,0.39,3e-06,5.52287874528033,"(case-only)",1.39,"[1.21-1.60] ","Illumina [421,318] (imputed)","N"]
["V3 (up-regulated)","04/06/2011",21383967,"Zhernakova A","02/24/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21383967","Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.","Celiac disease and Rheumatoid arthritis","4,533 European ancestry celiac disease cases, 5,539 European ancestry rheumatoid arthritis cases, 27,981 European ancestry controls","2,169 celiac disease cases, 2,845 rheumatoid arthritis cases, 7,199 controls","5q11.2",5,55560027,"ANKRD55",null,79722,345645,null,30.84,10.88,"rs1020388-?","rs1020388",0,1020388,null,1,"NR",3e-07,6.52287874528033,null,"NR","NR","Illumina [472,854]","N"]
["V3 (up-regulated)","03/25/2011",21305692,"Belmonte Mahon P","02/08/2011","Am J Med Genet B Neuropsychiatr Genet","http://www.ncbi.nlm.nih.gov/pubmed/21305692","Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder.","Bipolar disorder (age of onset and psychomotor symptoms)","2,836 European Caucasian cases; 2,744 European Caucasian controls","3,916 European Caucasian cases; 5,112 controls","7q36.1",7,151546589,"PRKAG2","- ",null,null,51422,null,null,"rs7795096-?","rs7795096",0,7795096,"intron",0,"NR",2e-06,5.69897000433601,"(psychomotor symptoms)",1.2,"[NR] ","Affymetrix & Illumina [2,373,895] (imputed)","N"]
["V3 (up-regulated)","03/28/2011",21300955,"Dehghan A","02/07/2011","Circulation","http://www.ncbi.nlm.nih.gov/pubmed/21300955","Meta-analysis of genome-wide association studies in &gt;80 000 subjects identifies multiple loci for C-reactive protein levels.","C-reactive protein","66,185 European ancestry individuals","16,540 European ancestry individuals","1q21.3",1,154426264,"IL6R","- ",null,null,3570,null,null,"rs4129267-C","rs4129267",0,4129267,"intron",0,"NR",2e-48,47.698970004336,null,0.08,"[0.07-0.09] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","03/29/2011",21297633,"Anderson CA","02/06/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21297633","Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.","Ulcerative colitis","6,687 European ancestry cases, 19,718 European ancestry controls","9,628 European ancestry cases, 12,917 European ancestry controls","1q23.3",1,161479745,"FCGR2A, FCGR2B, HSPA6","- ",null,null,2212,null,null,"rs1801274-A","rs1801274",0,1801274,"missense",0,0.51,2e-20,19.698970004336,null,1.21,"[1.16-1.26] ","Affymetrix & Illumina [~1.1 million] (imputed)","N"]
["V3 (up-regulated)","03/28/2011",21348951,"Parsa A","02/01/2011","Clin Transl Sci","http://www.ncbi.nlm.nih.gov/pubmed/21348951","Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.","Cardiac hypertrophy","851 Old Order Amish individuals",null,"1q41",1,216716537,"ESRRG","- ",null,null,2104,null,null,"rs12757165-?","rs12757165",0,12757165,"intron",0,"NR",1e-07,7,"(additive)","NR","NR","Affymetrix [361,034]","N"]
["V3 (up-regulated)","02/22/2011",21216879,"Kaplan RC","01/07/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21216879","A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3.","Insulin-like growth factors","10,280 European ancestry individuals","NR","6q21",6,108988184,"FOXO3","- ",null,null,2309,null,null,"rs2153960-A","rs2153960",0,2153960,"intron",0,0.69,5e-07,6.30102999566398,"(IGF-I)","NR","NR","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","01/11/2011",21172079,"Ingle JN","12/20/2010","Breast Cancer Res","http://www.ncbi.nlm.nih.gov/pubmed/21172079","Genome-wide case-control study of musculoskeletal adverse events and functional genomics in women receiving aromatase inhibitors: going beyond associations.","Adverse response to aromatase inhibitors","293 cases, 585 controls","NR","14q32.13",14,96175978,"TCL1A","- ",null,null,8115,null,null,"rs11849538-?","rs11849538",0,11849538,"intron",0,"NR",7e-07,6.15490195998574,null,"NR","NR","Illumina [551,395]","N"]
["V3 (up-regulated)","01/14/2011",21130836,"Luciano M","12/03/2010","Biol Psychol","http://www.ncbi.nlm.nih.gov/pubmed/21130836","Whole genome association scan for genetic polymorphisms influencing information processing speed.","Information processing speed","1,659 Caucasian individuals from 730 families, 2,374 European descent individuals","NR","10q25.3",10,117512588,"ATRNL1","- ",null,null,26033,null,null,"rs10490919-T","rs10490919",0,10490919,"intron",0,0.46,2e-06,5.69897000433601,"(digit symbol)",0.12,"[0.06-0.18] unit decrease","Illumina [~610,000]","N"]
["V3 (up-regulated)","01/12/2011",21116278,"Furney SJ","11/30/2010","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/21116278","Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.","Total ventricular volume"," (up-regulated) to 434 Caucasian MCI cases, 236 Caucasian AD cases, 284 Caucasian controls","NR","13q22.3",13,78808914,"EDNRB, POU4F1","- ",null,null,100874222,null,null,"rs9574199-?","rs9574199",0,9574199,"intron",0,"NR",7e-06,5.15490195998574,null,0,"[NR] unit increase (interaction)","Illumina [488,911]","N"]
["V3 (up-regulated)","01/08/2011",21107309,"McClay JL","11/24/2010","Neuropsychopharmacology","http://www.ncbi.nlm.nih.gov/pubmed/21107309","Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.","Working memory","738 schizophrenia cases","NR","3q28",3,189997396,"CLDN1",null,55214,9076,null,157.17,26.09,"rs16865258-?","rs16865258",0,16865258,null,1,0.02,2e-06,5.69897000433601,"(quetiapine)","NR","NR","Affymetrix [492,900]","N"]
["V3 (up-regulated)","01/08/2011",21102462,"Elks CE","11/21/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21102462","Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.","Menarche (age at onset)","87,802 European ancestry women"," (up-regulated) to 14,731 women","11p15.4",11,8639200,"TRIM66","- ",null,null,9866,null,null,"rs4929923-T","rs4929923",0,4929923,"UTR-3",0,0.36,1e-08,8,null,2.3,"[1.52-3.08] week increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","01/08/2011",21102462,"Elks CE","11/21/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21102462","Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.","Menarche (age at onset)","87,802 European ancestry women"," (up-regulated) to 14,731 women","20p12.1",20,17122593,"PCSK2",null,56914,5126,null,389.78,84.16,"rs852069-A","rs852069",0,852069,null,1,0.37,3e-08,7.52287874528033,null,2.1,"[1.32-2.88] week decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","10/19/2012",21102463,"Franke A","11/21/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21102463","Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.","Crohn's disease","6,333 European ancestry cases, 15,056 European ancestry controls","15,694 European ancestry cases, 14,026 European ancestry controls, 414 European ancestry parent-offspring trios","2q12.1",2,103054449,"IL18RAP,IL12RL2,IL18R1,IL1RL1","- ",null,null,8807,null,null,"rs2058660-G","rs2058660",0,2058660,"intron",0,0.231,2e-12,11.698970004336,null,1.19,"[1.14-1.26] ","Affymetrix & Illumina [953,241] (imputed)","N"]
["V3 (up-regulated)","01/06/2011",21076409,"Sotoodehnia N","11/14/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21076409","Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.","Ventricular conduction","40,407 European ancestry individuals","7,170 European ancestry individuals","13q22.1",13,74520186,"KLF12","- ",null,null,11278,null,null,"rs1886512-A","rs1886512",0,1886512,"intron",0,0.37,1e-08,8,null,0.4,"[0.26-0.54] ms decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","12/16/2010",21082022,"Padmanabhan S","10/28/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21082022","Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension.","Hypertension","1,621 Swedish cases, 1,699 Swedish controls","19,845 European ancestry cases, 16,541 European ancestry controls","16p12.3",16,20365654,"UMOD","- ",null,null,7369,null,null,"rs13333226-A","rs13333226",0,13333226,"nearGene-5",0,0.81,4e-11,10.397940008672,null,1.15,"[1.10-1.19] ","Illumina [521,220]","N"]
["V3 (up-regulated)","01/18/2011",20953190,"Strange A","10/17/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20953190","A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.","Psoriasis","2,178 European ancestry cases, 5,175 European ancestry controls","3,174 European ancestry cases, 5,464 European ancestry controls","6q23.3",6,138199417,"TNFAIP3","- ",null,null,7128,null,null,"rs610604-?","rs610604",0,610604,"intron",0,"NR",7e-07,6.15490195998574,null,1.22,"[1.13-1.32] ","Illumina [535,475]","N"]
["V3 (up-regulated)","11/17/2010",20935630,"Speliotes EK","10/10/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20935630","Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.","Body mass index"," (up-regulated) to 123,865 European ancestry individuals"," (up-regulated) to 125,931 European ancestry individuals","6p21.31",6,34302869,"NUDT3, HMGA1","- ",null,null,"11165;100529239",null,null,"rs206936-G","rs206936",0,206936,"intron;intron",0,0.21,3e-08,7.52287874528033,null,0.06,"[0.02-0.10] kg/m2 increase","Affymetrix, Illumina and Perlegen [~2.8 million] (imputed)","N"]
["V3 (up-regulated)","11/17/2010",20935630,"Speliotes EK","10/10/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20935630","Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.","Body mass index"," (up-regulated) to 123,865 European ancestry individuals"," (up-regulated) to 125,931 European ancestry individuals","11p14.1",11,27725986,"BDNF","- ",null,null,627,null,null,"rs10767664-A","rs10767664",0,10767664,"intron",0,0.78,5e-26,25.3010299956639,null,0.19,"[0.13-0.25] kg/m2 increase","Affymetrix, Illumina and Perlegen [~2.8 million] (imputed)","N"]
["V3 (up-regulated)","11/02/2012",20889312,"Wang KS","10/01/2010","Schizophr Res","http://www.ncbi.nlm.nih.gov/pubmed/20889312","A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.","Bipolar disorder and schizophrenia","651 European American bipolar cases, 1,171 European American schizophrenia cases, 2,412 European American controls","NR","9q33.1",9,121359286,"ASTN2",null,7099,1620,null,879.52,569.62,"rs11789399-?","rs11789399",0,11789399,null,1,"NR",6e-09,8.22184874961635,null,1.29,"[NR] ","Affymetrix [722,112]","N"]
["V3 (up-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","15q23",15,70048157,"TLE3",null,6176,100128431,null,300.27,47.3,"rs10152591-A","rs10152591",0,10152591,null,1,0.91,3e-10,9.52287874528033,null,0.04,"[NR] unit increase","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V3 (up-regulated)","10/15/2010",20876420,"Ingle JN","09/27/2010","J Clin Oncol","http://www.ncbi.nlm.nih.gov/pubmed/20876420","Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors.","Adverse response to aromatase inhibitors","293 cases, 585 controls","NR","14q32.13",14,96169131,"TCL1A",null,9623,8115,null,10.15,7.17,"rs7158782-?","rs7158782",0,7158782,null,1,0.11,8e-07,6.09691001300805,null,2.13,"[1.58-2.87] ","Illumina [551,395]","N"]
["V3 (up-regulated)","10/07/2010",20858683,"Soranzo N","09/21/2010","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/20858683","Common variants at 10 genomic loci influence hemoglobin A&#x02081;(C) levels via glycemic and nonglycemic pathways.","Glycated hemoglobin levels"," (up-regulated) to 46,368 European ancestry individuals","NR","2q31.1",2,169791438,"G6PC2,ABCB11","- ",null,null,8647,null,null,"rs552976-G","rs552976",0,552976,"intron",0,0.64,8e-18,17.096910013008,null,0.05,"[0.04-0.06] % increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","10/05/2010",20833655,"Cha PC","09/10/2010","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/20833655","Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese.","Warfarin maintenance dose","807 low dose Japanese, 707 high dose Japanese","444 individuals","10q23.33",10,96734339,"CYP2C9","- ",null,null,1559,null,null,"rs10509680-?","rs10509680",0,10509680,"intron",0,"NR",4e-07,6.39794000867203,null,"NR","NR","Illumina [485,227]","N"]
["V3 (up-regulated)","07/21/2011",20834067,"Yashin AI","09/01/2010","Aging (Albany NY)","http://www.ncbi.nlm.nih.gov/pubmed/20834067","Joint influence of small-effect genetic variants on human longevity.","Longevity","1,173 individuals","NR","2p16.3",2,50516018,"NRXN1","- ",null,null,9378,null,null,"rs1356888-?","rs1356888",0,1356888,"intron",0,"NR",1e-06,5.99999999999999,"(less than or equal to)","NR","NR","[~550,000]","N"]
["V3 (up-regulated)","09/22/2010",20713499,"Huang J","08/16/2010","Am J Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/20713499","Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression.","Schizophrenia, bipolar disorder and depression (combined)","402 European ancestry schizophrenia cases, 1,021 European ancestry bipolar I cases, 493 European ancestry bipolar II cases, 1,210 European ancestry MDD cases, 1,060 European ancestry controls","NR","14q13.1",14,33476266,"NPAS3","- ",null,null,64067,null,null,"rs4982029-A","rs4982029",0,4982029,"intron",0,0.02,4e-06,5.39794000867203,null,"NR","NR","Affymetrix & Perlegen [1,574,154] (imputed)","N"]
["V3 (up-regulated)","09/22/2010",20711174,"Hor H","08/15/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20711174","Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy.","Narcolepsy","562 European cases, 954 European controls","370 European cases, 495 European controls","14q11.2",14,23002684,"TRA@","- ",null,null,6955,null,null,"rs1154155-G","rs1154155",0,1154155,null,0,0.15,5e-07,6.30102999566398,null,1.54,"[1.30-1.95] ","Affymetrix [392,949]","N"]
["V3 (up-regulated)","09/24/2010",20708005,"Chalasani N","08/10/2010","Gastroenterology","http://www.ncbi.nlm.nih.gov/pubmed/20708005","Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.","Non-alcoholic fatty liver disease histology (lobular)","236 non-Hispanic Caucasian women","NR","10q22.1",10,71588504,"COL13A1","- ",null,null,1305,null,null,"rs1227756-G","rs1227756",0,1227756,"intron",0,0.46,2e-07,6.69897000433601,null,0.57,"[NR] unit increase","Illumina [324,623]","N"]
["V3 (up-regulated)","09/24/2010",20708005,"Chalasani N","08/10/2010","Gastroenterology","http://www.ncbi.nlm.nih.gov/pubmed/20708005","Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.","Non-alcoholic fatty liver disease histology (lobular)","236 non-Hispanic Caucasian women","NR","10q22.1",10,71583198,"COL13A1","- ",null,null,1305,null,null,"rs7077164-A","rs7077164",0,7077164,"intron",0,0.3,7e-06,5.15490195998574,null,0.67,"[NR] unit increase","Illumina [324,623]","N"]
["V3 (up-regulated)","09/21/2010",20694011,"Ferreira RC","08/08/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20694011","Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.","Immunoglobulin A ","430 Icelandic and Swedish cases, 1,090 Icelandic and Swedish controls","256 Spanish cases, 322 Spanish controls, 86 Finnish cases, 564 Finnish controls","11p11.2",11,46379442,"DGKZ, MDK, AMBRA1, HARBI1, ATG13, F2, CKAP5","- ",null,null,8525,null,null,"rs11038871-C","rs11038871",0,11038871,"intron",0,0.248,2e-06,5.69897000433601,null,1.36,"[1.19-1.55] ","Illumina [2,057,134] (imputed)","N"]
["V3 (up-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","Cholesterol, total"," (up-regulated) to 100,184 European descent individuals",null,"6p22.2",6,26093141,"HFE,HIST1H4C","- ",null,null,3077,null,null,"rs1800562-A","rs1800562",0,1800562,"missense",0,0.06,2e-08,7.69897000433601,null,2.16,"[1.32-3] mg/dL decrease","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V3 (up-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","HDL cholesterol","99,900 European descent individuals",null,"18q21.32",18,57849023,"RPS3A,MC4R",null,400652,4160,null,31.38,189.54,"rs12967135-A","rs12967135",0,12967135,null,1,0.23,7e-09,8.15490195998574,null,0.42,"[0.24-0.6] mg/dL decrease","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V3 (up-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","LDL cholesterol"," (up-regulated) to 95,454 European descent individuals",null,"6p22.2",6,26093141,"HFE,HIST1H4C","- ",null,null,3077,null,null,"rs1800562-A","rs1800562",0,1800562,"missense",0,0.06,6e-10,9.22184874961635,null,2.22,"[1.46-2.98] mg/dL decrease","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V3 (up-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","Triglycerides"," (up-regulated) to 96,598 European descent individuals",null,"5q11.2",5,55861786,"ANKRD55,MAP3K1",null,441073,4214,null,60.85,249.11,"rs9686661-T","rs9686661",0,9686661,null,1,0.2,1e-10,10,null,2.57,"[1.61-3.53] mg/dL increase","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V3 (up-regulated)","09/14/2010",20691247,"Verweij KJ","08/04/2010","Biol Psychol","http://www.ncbi.nlm.nih.gov/pubmed/20691247","A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality.","Personality dimensions","5,117 individuals from 2,567 families","NR","2p16.3",2,50744774,"NRXN1","- ",null,null,9378,null,null,"rs10176705-T","rs10176705",0,10176705,"intron",0,0.37,9e-06,5.04575749056067,"(Novelty Seeking)",0.1,"[NR] unit increase","Affymetrix & Illumina [1,252,387] (imputed)","N"]
["V3 (up-regulated)","09/13/2010",20694148,"Zabaneh D","08/04/2010","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/20694148","A genome-wide association study of the metabolic syndrome in Indian Asian men.","Metabolic syndrome","2,554 Indian Asian men","2,240 Indian Asian men","18q21.32",18,57751014,"PMAIP1",null,728115,400652,null,66.21,65.76,"rs12957347-?","rs12957347",0,12957347,null,1,0.36,7e-06,5.15490195998574,"(Metabolic syndrome)","NR","NR","Illumina [308,011]","N"]
["V3 (up-regulated)","09/11/2010",20686651,"Gudbjartsson DF","07/29/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20686651","Association of variants at UMOD with chronic kidney disease and kidney stones-role of age and comorbid diseases.","Chronic kidney disease and serum creatinine levels","2,903 Icelandic CKD cases, 35,818 Icelandic controls, 22,256 Icelandic subjects with serum creatinine","300 Icelandic CKD cases, 2,964 Icelandic controls, 2,379 Icelandic subjects with serum creatinine, 1,819 Dutch subjects with serum creatinine","16p12.3",16,20364588,"UMOD","- ",null,null,7369,null,null,"rs4293393-T","rs4293393",0,4293393,"nearGene-5",0,0.798,4e-10,9.39794000867203,"(CKD)",1.25,"[1.17-1.35] ","Illumina [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","08/17/2010",20610895,"Koriyama H","07/02/2010","J Atheroscler Thromb","http://www.ncbi.nlm.nih.gov/pubmed/20610895","Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population.","Peripheral artery disease","195 Japanese cases, 1,358 Japanese controls","699 Japanese cases, 1,540 Japanese controls","3p23",3,31795570,"OSBPL10","- ",null,null,114884,null,null,"rs1902341-G","rs1902341",0,1902341,"intron",0,0.397,5e-07,6.30102999566398,null,1.31,"[1.18-1.46] ","Perlegen [222,285]","N"]
["V3 (up-regulated)","07/16/2010",20585627,"Eriksson N","06/24/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20585627","Web-based, participant-driven studies yield novel genetic associations for common traits.","Eye color","9,126 European ancestry individuals","NR","6p25.3",6,396321,"IRF4","- ",null,null,3662,null,null,"rs12203592-T","rs12203592",0,12203592,"intron",0,0.18,2e-15,14.698970004336,"(eye color)",0.42,"[NR] unit decrease","Illumina [535,076]","N"]
["V3 (up-regulated)","07/16/2010",20585627,"Eriksson N","06/24/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20585627","Web-based, participant-driven studies yield novel genetic associations for common traits.","Freckling","9,126 European ancestry individuals","NR","6p25.3",6,396321,"IRF4","- ",null,null,3662,null,null,"rs12203592-T","rs12203592",0,12203592,"intron",0,0.18,2e-91,90.698970004336,null,1.61,"[NR] unit increase","Illumina [535,076]","N"]
["V3 (up-regulated)","07/16/2010",20585627,"Eriksson N","06/24/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20585627","Web-based, participant-driven studies yield novel genetic associations for common traits.","Hair color","9,126 European ancestry individuals","NR","6p25.3",6,396321,"IRF4","- ",null,null,3662,null,null,"rs12203592-T","rs12203592",0,12203592,"intron",0,0.18,2e-28,27.698970004336,"(hair color)",0.59,"[NR] unit increase","Illumina [535,076]","N"]
["V3 (up-regulated)","07/12/2010",20570966,"McGovern DP","06/22/2010","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/20570966","Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.","Crohn's disease","896 European ancestry cases, 3,204 European ancestry controls","1,174 European ancestry cases, 357 European ancestry controls","6q27",6,167437988,"CCR6,FGFR10P,RNASE2","- ",null,null,11116,null,null,"rs2301436-?","rs2301436",0,2301436,"intron",0,"NR",6e-08,7.22184874961635,null,1.37,"[1.22-1.53] ","Illumina [304,825]","N"]
["V3 (up-regulated)","06/22/2010",20526338,"Johnson AD","06/06/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20526338","Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.","Platelet aggregation"," (up-regulated) to 3,991 European ancestry individuals"," (up-regulated) to 840 African American individuals","9p24.1",9,8196511,"PTPRD",null,90871,100127999,null,396.71,516.77,"rs7044355-G","rs7044355",0,7044355,null,1,0.501,1e-07,7,"(collagen)","NR","NR","Affymetrix & Illumina [~2.33 million] (imputed)","N"]
["V3 (up-regulated)","06/22/2010",20522523,"Kasperaviciute D","06/03/2010","Brain","http://www.ncbi.nlm.nih.gov/pubmed/20522523","Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.","Partial epilepsies"," (up-regulated) to 3,445 European ancestry cases, 6,935 European ancestry controls","NR","9p23",9,10260263,"PTPRD","- ",null,null,5789,null,null,"rs2475335-?","rs2475335",0,2475335,"intron",0,"NR",9e-06,5.04575749056067,null,"NR","NR","Illumina [528,745]","N"]
["V3 (up-regulated)","06/13/2010",20453841,"Kochi Y","05/09/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20453841","A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.","Rheumatoid arthritis","2,303 Japanese cases, 3,380 Japanese controls","4,768 Japanese cases, 17,359 Japanese controls","6q23.3",6,138196066,"OLIG3,TNFAIP3","- ",null,null,7128,null,null,"rs2230926-C","rs2230926",0,2230926,"missense",0,0.07,2e-06,5.69897000433601,null,1.31,"[1.17-1.46] ","Illumina [393,217]","N"]
["V3 (up-regulated)","06/13/2010",20453842,"Stahl EA","05/09/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20453842","Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.","Rheumatoid arthritis","5,539 European ancestry cases, 20,169 European ancestry controls","6,768 European ancestry cases, 8,806 European ancestry controls","6q23.3",6,138006504,"TNFAIP3",null,391040,7128,null,140.92,181.82,"rs6920220-A","rs6920220",0,6920220,null,1,0.22,9e-13,12.0457574905606,null,1.22,"[1.16-1.29] ","Affymetrix & Illumina [~2,716,259] (imputed)","N"]
["V3 (up-regulated)","06/13/2010",20453842,"Stahl EA","05/09/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20453842","Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.","Rheumatoid arthritis","5,539 European ancestry cases, 20,169 European ancestry controls","6,768 European ancestry cases, 8,806 European ancestry controls","5q11.2",5,55438580,"ANKRD55,IL6ST","- ",null,null,79722,null,null,"rs6859219-C","rs6859219",0,6859219,"intron",0,0.79,1e-11,11,null,1.28,"[NR] ","Affymetrix & Illumina [~2,716,259] (imputed)","N"]
["V3 (up-regulated)","05/24/2010",20418890,"The Tobacco and Genetics Consortium","04/25/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20418890","Genome-wide meta-analyses identify multiple loci associated with smoking behavior.","Smoking behavior"," (up-regulated) to 74,035 European ancestry individuals"," (up-regulated) to 68,988 participants","11p14.1",11,27679916,"BDNF","- ",null,null,"627;497258",null,null,"rs6265-C","rs6265",0,6265,"missense;ncRNA",0,0.79,2e-08,7.69897000433601,"(smoking initiation)",1.06,"[1.04-1.08] ","Affymetrix, Illumina and Perlegen [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","05/24/2010",20418888,"Thorgeirsson TE","04/25/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20418888","Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.","Smoking behavior","31,266 European ancestry individuals","54,731 European descent individuals","8p11.21",8,42550498,"CHRNB3,CHRNA6",null,114926,1142,null,142.36,2.06,"rs6474412-T","rs6474412",0,6474412,null,1,0.78,1e-08,8,null,0.29,"[0.19-0.39] CPD increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","05/18/2010",20395239,"Macgregor S","04/15/2010","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/20395239","Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.","Optic disc size (c (up-regulated))","1,368 Australian twins, 848 UK individuals","NR","1q41",1,217058479,"ESRRG","- ",null,null,2104,null,null,"rs1436900-T","rs1436900",0,1436900,"intron",0,"NR",7e-06,5.15490195998574,null,0.14,"[0.06-0.22] unit decrease","Illumina [~2.74 million] (imputed)","N"]
["V3 (up-regulated)","05/05/2010",20383146,"Kottgen A","04/11/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20383146","New loci associated with kidney function and chronic kidney disease.","Chronic kidney disease"," (up-regulated) to 67,093 European ancestry individuals"," (up-regulated) to 22,982 European ancestry individuals","16p12.3",16,20367690,"UMOD,ACSM5,GP2,PDILT",null,7369,204474,null,3.65,2.8,"rs12917707-T","rs12917707",0,12917707,null,1,0.18,1e-20,20,"(eGFRcrea)","NR","NR","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","05/05/2010",20383146,"Kottgen A","04/11/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20383146","New loci associated with kidney function and chronic kidney disease.","Chronic kidney disease"," (up-regulated) to 67,093 European ancestry individuals"," (up-regulated) to 22,982 European ancestry individuals","7q36.1",7,151407801,"PRKAG2","- ",null,null,51422,null,null,"rs7805747-A","rs7805747",0,7805747,"intron",0,0.24,4e-12,11.397940008672,"(CKD)",1.18,"[1.12-1.25] ","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","04/15/2010",20351715,"Liu Y","03/30/2010","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/20351715","Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.","Bipolar disorder and major depressive disorder (combined)","4,387 Caucasian bipolar cases, 6,209 Caucasian controls, 1,695 Dutch MDD cases, 1,761 Dutch controls","NR","10q21.2",10,62181128,"ANK3","- ",null,null,288,null,null,"rs10994338-A","rs10994338",0,10994338,"intron",0,"NR",5e-07,6.30102999566398,null,"NR","NR","Affymetrix & Perlegen [1,472,580] (imputed)","N"]
["V3 (up-regulated)","04/14/2010",20339536,"Barber MJ","03/22/2010","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/20339536","Genome-wide association of lipid-lowering response to statins in combined study populations.","Response to statin therapy","3,928 Caucasian individuals","NR","2q22.3",2,148478336,"ACVR2A, ORC4L, LOC647065",null,728773,100133235,null,1129.78,81.08,"rs7584099-G","rs7584099",0,7584099,null,1,0.41,5e-07,6.30102999566398,"(Triglyceride, diff)","NR","NR","Illumina [~2.5 million](imputed)","N"]
["V3 (up-regulated)","04/14/2010",20339536,"Barber MJ","03/22/2010","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/20339536","Genome-wide association of lipid-lowering response to statins in combined study populations.","Response to statin therapy","3,928 Caucasian individuals","NR","12p12.1",12,24278821,"SOX5, FLJ32894, BCAT1","- ",null,null,6660,null,null,"rs7979575-C","rs7979575",0,7979575,"intron",0,0.16,2e-06,5.69897000433601,"(Triglyceride, sum)","NR","NR","Illumina [~2.5 million](imputed)","N"]
["V3 (up-regulated)","04/12/2010",20303064,"Houlihan LM","03/18/2010","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/20303064","Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time.","Activated partial thromboplastin time","1,431 Scottish adults","NR","3q27.3",3,186390627,"HRG","- ",null,null,3273,null,null,"rs9898-T","rs9898",0,9898,"missense",0,0.32,1e-11,11,null,0.26,"[0.19-0.33] unit increase","Illumina [542,050]","N"]
["V3 (up-regulated)","04/02/2010",20228799,"McGovern DP","03/14/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20228799","Genome-wide association identifies multiple ulcerative colitis susceptibility loci.","Ulcerative colitis","2,693 European descent cases, 6,791 European descent controls","2,009 European descent cases, 1,580 European descent controls","1q23.3",1,161472158,"FCGR2A,FCGR2C",null,6244,2212,null,123,3.05,"rs10800309-A","rs10800309",0,10800309,null,1,"NR",3e-09,8.52287874528033,null,1.2,"[NR] ","Affymetrix [266,047]","N"]
["V3 (up-regulated)","04/02/2010",20228799,"McGovern DP","03/14/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20228799","Genome-wide association identifies multiple ulcerative colitis susceptibility loci.","Ulcerative colitis","2,693 European descent cases, 6,791 European descent controls","2,009 European descent cases, 1,580 European descent controls","1p36.13",1,20140036,"RNF186,OTUD3,PLA2G2E","- ",null,null,54546,null,null,"rs1317209-T","rs1317209",0,1317209,"nearGene-3",0,"NR",2e-10,9.69897000433601,null,1.17,"[NR] ","Affymetrix [266,047]","N"]
["V3 (up-regulated)","04/02/2010",20228799,"McGovern DP","03/14/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20228799","Genome-wide association identifies multiple ulcerative colitis susceptibility loci.","Ulcerative colitis","2,693 European descent cases, 6,791 European descent controls","2,009 European descent cases, 1,580 European descent controls","1p36.13",1,20171860,"RNF186,OTUD3,PLA2G2E",null,54546,23252,null,30.09,37.03,"rs6426833-A","rs6426833",0,6426833,null,1,"NR",2e-21,20.698970004336,null,1.3,"[NR] ","Affymetrix [266,047]","N"]
["V3 (up-regulated)","04/06/2010",20195266,"Adkins DE","03/02/2010","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/20195266","Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.","Response to antipsychotic treatment","738 European American, African American, and other schizophrenia cases","NR","12p12.1",12,24389660,"SOX5","- ",null,null,6660,null,null,"rs1464500-?","rs1464500",0,1464500,"intron",0,0.232,1e-07,7,"(perphenazine-HDL)","NR","NR","Affymetrix [492,900]","N"]
["V3 (up-regulated)","04/06/2010",20195266,"Adkins DE","03/02/2010","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/20195266","Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.","Response to antipsychotic treatment","738 European American, African American, and other schizophrenia cases","NR","9q33.1",9,119926426,"ASTN2","- ",null,null,23245,null,null,"rs4838255-?","rs4838255",0,4838255,"intron",0,0.139,3e-07,6.52287874528033,"(perphenazine-triglycerides)","NR","NR","Affymetrix [492,900]","N"]
["V3 (up-regulated)","03/29/2010",20190752,"Dubois PC","02/28/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20190752","Multiple common variants for celiac disease influencing immune gene expression.","Celiac disease","4,533 European descent cases, 10,750 European descent controls","4,918 European descent cases, 5,684 European descent controls","6q23.3",6,137973068,"TNFAIP3",null,391040,7128,null,107.49,215.26,"rs2327832-G","rs2327832",0,2327832,null,1,0.22,4e-19,18.397940008672,null,1.23,"[1.17-1.28] ","Illumina [292,387]","N"]
["V3 (up-regulated)","03/29/2010",20190752,"Dubois PC","02/28/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20190752","Multiple common variants for celiac disease influencing immune gene expression.","Celiac disease","4,533 European descent cases, 10,750 European descent controls","4,918 European descent cases, 5,684 European descent controls","6p25.3",6,383546,"IRF4",null,56940,3662,null,32.19,8.19,"rs1033180-A","rs1033180",0,1033180,null,1,0.08,6e-08,7.22184874961635,null,1.21,"[1.13-1.29] ","Illumina [292,387]","N"]
["V3 (up-regulated)","03/29/2010",20190752,"Dubois PC","02/28/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20190752","Multiple common variants for celiac disease influencing immune gene expression.","Celiac disease","4,533 European descent cases, 10,750 European descent controls","4,918 European descent cases, 5,684 European descent controls","2q12.1",2,103070568,"IL18RAP, IL18R1, IL1RL1, IL1RL2",null,8807,389015,null,1.54,19.19,"rs917997-A","rs917997",0,917997,null,1,0.24,1e-15,15,null,1.19,"[1.14-1.25] ","Illumina [292,387]","N"]
["V3 (up-regulated)","03/25/2010",20189936,"Okada Y","02/26/2010","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/20189936","A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.","Height","19,633 Japanese individuals","NR","9q34.3",9,139121740,"LHX3, QSOX2","- ",null,null,169714,null,null,"rs12338076-C","rs12338076",0,12338076,"intron",0,0.34,2e-08,7.69897000433601,null,0.06,"[0.04-0.08] cm increase","Illumina [420,885]","N"]
["V3 (up-regulated)","03/25/2010",20185149,"Athanasiu L","02/23/2010","J Psychiatr Res","http://www.ncbi.nlm.nih.gov/pubmed/20185149","Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort.","Schizophrenia","201 Caucasian cases, 305 European controls","2,663 European cases, 13,780 European controls","10q21.2",10,62085337,"ANK3","- ",null,null,288,null,null,"rs10761482-?","rs10761482",0,10761482,"intron",0,"NR",8e-06,5.09691001300805,null,1.16,"[NR] ","Affymetrix [572,888]","N"]
["V3 (up-regulated)","03/17/2010",20174558,"Tsai FJ","02/19/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20174558?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese.","Type 2 diabetes","995 Han Chinese cases, 894 Han Chinese controls","1,803 Han Chinese cases, 1,473 Han Chinese controls","9p24.1",9,8879118,"PTPRD","- ",null,null,5789,null,null,"rs17584499-T","rs17584499",0,17584499,"intron",0,0.06,9e-10,9.04575749056067,null,1.57,"[1.36-1.82] ","Illumina [516,737]","N"]
["V3 (up-regulated)","02/28/2010",20101243,"Petersen GM","01/24/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20101243?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=11","A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.","Pancreatic cancer","3,851 cases, 3,934 controls","NR","13q22.1",13,73916628,"KLF5, KLF12",null,100873807,100421565,null,115.23,65.3,"rs9543325-C","rs9543325",0,9543325,null,1,0.37,3e-11,10.5228787452803,null,1.26,"[1.18-1.35] ","Illumina [551,766]","N"]
["V3 (up-regulated)","02/28/2010",20081858,"D (up-regulated)uis J","01/17/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20081858?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.","Fasting glucose-related traits"," (up-regulated) to 46,186 European descent individuals"," (up-regulated) to 76,558 European ancestry individuals","2q31.1",2,169763148,"G6PC2","- ",null,null,57818,null,null,"rs560887-C","rs560887",0,560887,"intron",0,0.7,9e-218,217.04575749056,"(FPG)","NR","NR","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","02/28/2010",20081858,"D (up-regulated)uis J","01/17/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20081858?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.","Fasting glucose-related traits"," (up-regulated) to 46,186 European descent individuals"," (up-regulated) to 76,558 European ancestry individuals","2q31.1",2,169763148,"G6PC2","- ",null,null,57818,null,null,"rs560887-C","rs560887",0,560887,"intron",0,0.7,2e-66,65.698970004336,"(HOMA-B)","NR","NR","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","02/04/2010",20062060,"Pfeufer A","01/10/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20062060?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Genome-wide association study of PR interval.","PR interval","28,517 European descent individuals","NR","12p12.1",12,24788339,"SOX5, C12orf67",null,144360,100271432,null,51.24,7.25,"rs11047543-A","rs11047543",0,11047543,null,1,0.15,3e-13,12.5228787452803,null,2.09,"[1.53-2.65] ms decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","01/19/2010",20041166,"Fellay J","12/24/2009","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20041166?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Common genetic variation and the control of HIV-1 in humans.","HIV-1 control","2,362 Caucasian cases","NR","6p21.32",6,32376471,"BTNL2, NOTCH4","- ",null,null,56244,null,null,"rs3763313-?","rs3763313",0,3763313,"nearGene-5",0,"NR",2e-06,5.69897000433601,"(progression)","NR","NR","Illumina [NR]","N"]
["V3 (up-regulated)","12/04/2009",19893584,"Kim JJ","11/06/2009","J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/19893584","Identification of 15 loci influencing height in a Korean population.","Height","8,842 Korean individuals","NR","6p21.31",6,34238514,"HMGA1, C6orf1, NUDT3",null,646766,11165,null,7.01,16.46,"rs6918981-G","rs6918981",0,6918981,null,1,0.21,2e-08,7.69897000433601,null,0.55,"[NR] cm increase","Affymetrix [334,546]","N"]
["V3 (up-regulated)","11/09/2009",19838193,"Han JW","10/18/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19838193?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2","Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic l (up-regulated)us erythematosus.","Systemic l (up-regulated)us erythematosus","1,047 Chinese Han cases, 1,205 Chinese Han controls","3,152 Chinese Han cases, 7,050 Chinese Han controls","6q23.3",6,138196066,"TNFAIP3","- ",null,null,7128,null,null,"rs2230926-C","rs2230926",0,2230926,"missense",0,0.04,1e-17,17,null,1.72,"[1.52-1.94] ","Illumina [493,955]","N"]
["V3 (up-regulated)","11/03/2009",19862010,"Ganesh SK","10/11/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19862010?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.","Hematocrit","24,167 European ancestry individuals","9,456 European ancestry individuals","7q36.1",7,151415041,"PRKAG2","- ",null,null,51422,null,null,"rs10224002-G","rs10224002",0,10224002,"intron",0,"NR",6e-15,14.2218487496163,null,0.2,"[0.15-0.25] % increase","Affymetrix & Illumina [~2.5 million](imputed)","N"]
["V3 (up-regulated)","11/03/2009",19862010,"Ganesh SK","10/11/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19862010?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.","Hemoglobin","24,167 European ancestry individuals","9,456 European ancestry individuals","7q36.1",7,151415041,"PRKAG2","- ",null,null,51422,null,null,"rs10224002-G","rs10224002",0,10224002,"intron",0,"NR",3e-15,14.5228787452803,null,0.07,"[0.05-0.09] g/dl increase","Affymetrix & Illumina [~2.5 million](imputed)","N"]
["V3 (up-regulated)","09/30/2009",19754311,"Le Clerc S","09/15/2009","J Infect Dis","http://www.ncbi.nlm.nih.gov/pubmed/19754311?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03).","AIDS","85 French cases, 2,049 French controls","NR","12p12.1",12,24394372,"SOX5","- ",null,null,6660,null,null,"rs1522232-C","rs1522232",0,1522232,"intron",0,0.52,2e-06,5.69897000433601,null,2.22,"[1.59-3.13] ","Illumina [291,119]","N"]
["V3 (up-regulated)","09/30/2009",20061627,"Heinzen EL","09/11/2009","J Alzheimers Dis","http://www.ncbi.nlm.nih.gov/pubmed/20061627","Genome-wide scan of copy number variation in late-onset Alzheimer's disease.","Alzheimer's disease","331 cases, 368 controls","NR","10q24.31",10,102501571,"PAX2",null,55662,5076,null,187.89,3.9,"rs4509693-?","rs4509693",0,4509693,null,1,0.18,6e-06,5.22184874961635,null,"NR","NR","Illumina [~550,000]","N"]
["V3 (up-regulated)","09/29/2009",19734902,"Harold D","09/06/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19734902?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.","Alzheimer's disease","3,941 European ancestry cases, 7,848 European ancestry controls","2,023 European ancestry cases, 2,340 European ancestry controls","11q14.2",11,85868640,"PICALM",null,8301,283226,null,87.72,37.53,"rs3851179-?","rs3851179",0,3851179,null,1,0.63,1e-09,8.99999999999999,null,1.16,"[1.11-1.22] ","Illumina [529,205]","N"]
["V3 (up-regulated)","11/08/2012",19734545,"Need AC","09/04/2009","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19734545?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.","Cognitive performance"," (up-regulated) to 1,295 individuals","NR","3p22.1",3,39553788,"MOBP","- ",null,null,4336,null,null,"rs816488-?","rs816488",0,816488,"intron",0,0.04479,4e-06,5.39794000867203,"(IED)","NR","NR","Illumina [475,971]","N"]
["V3 (up-regulated)","09/09/2009",19706858,"Shuldiner AR","08/26/2009","JAMA","http://www.ncbi.nlm.nih.gov/pubmed/19706858","Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.","Response to clopidogrel therapy","429 Amish individuals","140 European ancestry individuals, 83 African American individuals, 4 individuals","10q23.33",10,96405502,"CYP2C18, CYP2C19, CYP2C9, CYP2C8",null,3070,1562,null,43.65,37.75,"rs12777823-?","rs12777823",0,12777823,null,1,0.17,2e-13,12.698970004336,"(Amish)","NR","NR","Affymetrix [400,230]","N"]
["V3 (up-regulated)","07/13/2009",19578365,"Falchi M","07/05/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19578365","Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi.","Cutaneous nevi","1,524 European ancestry twins","4,107 European ancestry individuals","9p21.3",9,21747803,"MTAP",null,402359,100418937,null,47.73,63.85,"rs4636294-A","rs4636294",0,4636294,null,1,0.48,3e-15,14.5228787452803,null,0.2,"[0.13-0.27] increase in log nevus count","Illumina [297,108]","N"]
["V3 (up-regulated)","07/12/2009",19567438,"Elliott P","07/01/2009","JAMA","http://www.ncbi.nlm.nih.gov/pubmed/19567438","Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.","C-reactive protein","17,967 European ancestry and Asian Indian men and women","13,615 European ancestry and Asian Indian men and women","1q21.3",1,154418879,"IL6R","- ",null,null,3570,null,null,"rs4537545-T","rs4537545",0,4537545,"intron",0,"NR",2e-14,13.698970004336,null,11.5,"[8.5-14.4] % decrease","Affymetrix, Illumina & Perlegen [~1.4 million] (imputed)","N"]
["V3 (up-regulated)","07/10/2009",19571809,"Shi J","07/01/2009","Nature","http://www.ncbi.nlm.nih.gov/pubmed/19571809","Common variants on chromosome 6p22.1 are associated with schizophrenia.","Schizophrenia","2,681 European ancestry cases, 2,653 European ancestry controls, 1,286 African American cases, 973 African American controls","5,327 European ancestry cases, 16,424 European ancestry controls","6p22.1",6,27143883,"SLC17A1, SLC17A3, BTN3A2, BTN2A2, BTN3A1, HIST1H2AG, HIST1H2BJ, PRSS16, POM121L2, ZNF184",null,100422934,442171,null,28.42,35.14,"rs13194053-T","rs13194053",0,13194053,null,1,0.82,1e-08,8,"(EA)",1.28,"[NR] ","Affymetrix [ (up-regulated) to 843,798]","N"]
["V3 (up-regulated)","07/10/2009",19571808,"Stefansson H","07/01/2009","Nature","http://www.ncbi.nlm.nih.gov/pubmed/19571808","Common variants conferring risk of schizophrenia.","Schizophrenia","2,663 European ancestry cases, 13,498 European ancestry controls","10,282 European ancestry cases, 21,093 European ancestry controls","6p21.32",6,32172993,"MHC, NOTCH4","- ",null,null,4855,null,null,"rs3131296-G","rs3131296",0,3131296,"intron",0,0.87,2e-10,9.69897000433601,null,1.19,"[NR] ","Illumina [314,868]","N"]
["V3 (up-regulated)","06/30/2009",19525955,"Bahlo","06/14/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19525955?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.","Multiple sclerosis","1,618 European ancestry cases, 3,413 European ancestry controls","2,256 European ancestry cases, 2,310 European ancestry controls","12q14.1",12,58162739,"METTL1, CYP27B1","- ",null,null,"1594;4234",null,null,"rs703842-A","rs703842",0,703842,"nearGene-5;UTR-3",0,0.67,5e-11,10.3010299956639,null,1.23,"[NR] ","Illumina [302,098]","N"]
["V3 (up-regulated)","06/04/2009",19451621,"Landers JE","05/18/2009","Proc Natl Acad Sci U S A","http://www.ncbi.nlm.nih.gov/pubmed/19451621?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.","Amyotrophic lateral sclerosis","1,821 cases, 2,258 controls","538 cases, 556 controls","5q23.1",5,115727838,"SEMA6A",null,100874471,57556,null,173.85,51.41,"rs7702057-A","rs7702057",0,7702057,null,1,0.03,8e-06,5.09691001300805,"(site of onset)",2.05,"[NR] ","Illumina [288,357]","N"]
["V3 (up-regulated)","05/27/2009",19430482,"Kottgen A","05/10/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19430482?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Multiple loci associated with indices of renal function and chronic kidney disease.","Renal function and chronic kidney disease","19,877 individuals,  (up-regulated) to 2,388 cases","21,466 individuals,  (up-regulated) to 1,932 cases","16p12.3",16,20367690,"UMOD",null,7369,204474,null,3.65,2.8,"rs12917707-T","rs12917707",0,12917707,null,1,0.18,5e-16,15.3010299956639,"(eGFRcrea)",0.02,"[0.014-0.022] ml/min/1.73m2 increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","05/27/2009",19430482,"Kottgen A","05/10/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19430482?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Multiple loci associated with indices of renal function and chronic kidney disease.","Renal function and chronic kidney disease","19,877 individuals,  (up-regulated) to 2,388 cases","21,466 individuals,  (up-regulated) to 1,932 cases","16p12.3",16,20367690,"UMOD",null,7369,204474,null,3.65,2.8,"rs12917707-G","rs12917707",0,12917707,null,1,0.82,2e-12,11.698970004336,"(CKD)",1.25,"[1.18-1.33] ","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","05/12/2009",19414484,"Johnson AD","05/04/2009","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19414484?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association meta-analysis for total serum bilirubin levels.","Bilirubin levels","9,264 individuals","NR","6p22.2",6,26116982,"HIST1H2BC",null,3010,8347,null,8.62,6.71,"rs12206204-T","rs12206204",0,12206204,null,1,0.02,8e-07,6.09691001300805,null,0.18,"[0.10-0.26] umol/l increase in log(tbil)","Affymetrix & Illumina [2,555,103] (imputed)","N"]
["V3 (up-regulated)","12/29/2009",20031577,"Danik JS","04/01/2009","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/20031577","Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.","Fibrinogen","17,686 European ancestry women","NR","1q21.3",1,154426970,"IL6R","- ",null,null,3570,null,null,"rs8192284-C","rs8192284",1,2228145,"missense",0,0.4,2e-11,10.698970004336,null,5.3,"[NR] mg/dl decrease","Illumina [337,343]","N"]
["V3 (up-regulated)","03/31/2009",19305408,"Newton-Cheh C","03/22/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19305408?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Common variants at ten loci influence QT interval duration in the QTGEN Study.","QT interval","13,685 individuals","15,854 individuals","16p13.13",16,11691753,"LITAF,CLEC16A, SNN, ZC3H7A, TNFRSF17",null,9516,8303,null,10.43,70.54,"rs8049607-T","rs8049607",0,8049607,null,1,0.49,5e-15,14.3010299956639,null,1.23,"[0.88-1.57] msec increase","Affymetrix and Illumina [ (up-regulated) to 2,543,686] (imputed)","N"]
["V3 (up-regulated)","03/30/2009",19300499,"Takeuchi F","03/20/2009","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/19300499?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.","Warfarin maintenance dose","1,053 individuals","588 individuals","10q23.33",10,96702047,"CYP2C9","- ",null,null,1559,null,null,"rs1799853-?","rs1799853",0,1799853,"missense",0,0.11,1e-31,31,null,0.54,"[0.45-0.63] mg/week decrease","Illumina [325,997]","N"]
["V3 (up-regulated)","03/30/2009",19300499,"Takeuchi F","03/20/2009","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/19300499?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.","Warfarin maintenance dose","1,053 individuals","588 individuals","10q23.33",10,96741053,"CYP2C9","- ",null,null,1559,null,null,"rs1057910-?","rs1057910",0,1057910,"missense",0,0.07,3e-79,78.5228787452803,null,1.11,"[1.00-1.22] mg/week decrease","Illumina [325,997]","N"]
["V3 (up-regulated)","04/01/2009",19303062,"Tanaka T","03/18/2009","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/19303062?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.","Folate pathway vitamin levels","2,934 individuals","686 individuals","11q12.1",11,59633493,"TCN1","- ",null,null,6947,null,null,"rs526934-A","rs526934",0,526934,"intron",0,0.67,2e-06,5.69897000433601,"(vitamin B12)",27.62,"[11.65-43.59] pg/mL increase","Affymetrix and Illumina [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","03/01/2009",19198610,"Gudbjartsson DF","02/08/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19198610","Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.","Eosinophil counts","9,392 European ancestry individuals","12,118 European ancestry individuals, 5,212 East Asian ancestry individuals","2q12.1",2,102957716,"IL1RL1","- ",null,null,9173,null,null,"rs1420101-A","rs1420101",0,1420101,"intron",0,0.41,5e-14,13.3010299956639,"(European)",6.4,"[4.7-8.1] % standard unit increase","Illumina [312,179]","N"]
["V3 (up-regulated)","02/27/2009",19196962,"Garcia-Barcelo MM","02/05/2009","Proc Natl Acad Sci U S A","http://www.ncbi.nlm.nih.gov/pubmed/19196962","Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease.","Hirschsprung's disease","181 Chinese ancestry cases, 346 Chinese ancestry controls","190 Chinese ancestry cases, 510 Chinese ancestry controls","10q11.21",10,43612609,"RET, GALNACT-2, RASGEF1A","- ",null,null,5979,null,null,"rs2742234-T","rs2742234",0,2742234,"intron",0,"NR",4e-18,17.397940008672,null,"NR","NR","Affymetrix [293,836]","N"]
["V3 (up-regulated)","03/31/2009",19260141,"Zemunik T","02/01/2009","Croat Med J","http://www.ncbi.nlm.nih.gov/pubmed/19260141?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association study of biochemical traits in Korcula Island, Croatia.","Biochemical measures","898 individuals","NR","20p12.1",20,17368542,"PCSK2","- ",null,null,5126,null,null,"rs6044777-A","rs6044777",0,6044777,"intron",0,0.17,8e-06,5.09691001300805,"(fibrinogen)",0.23,"[0.13-0.33] g/L increase","Illumina [316,730]","N"]
["V3 (up-regulated)","02/06/2009",19169254,"Nair RP","01/25/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19169254?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.","Psoriasis","1,359 cases, 1,400 controls","5,048 cases, 5,041 controls","6q23.3",6,138199417,"TNFAIP3","- ",null,null,7128,null,null,"rs610604-G","rs610604",0,610604,"intron",0,0.32,9e-12,11.0457574905606,null,1.19,"[NR] ","Perlegen [~2.5 million] (imputed)","N"]
["V3 (up-regulated)","01/21/2009",19122664,"Silverberg MS","01/04/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19122664?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.","Ulcerative colitis","1,022 cases, 2,503 controls","1,387 cases, 1,115 controls","1p36.13",1,20142866,"RNF186","- ",null,null,54546,null,null,"rs3806308-?","rs3806308",0,3806308,"nearGene-5",0,0.63,7e-09,8.15490195998574,null,1.28,null,"Illumina [280,748]","N"]
["V3 (up-regulated)","06/22/2009",19096518,"Pare G","12/19/2008","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/19096518","Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.","Glycated hemoglobin levels","14,618 European ancestry women","455 European ancestry men and women","2q31.1",2,169757354,"G6PC2","- ",null,null,57818,null,null,"rs1402837-A","rs1402837",0,1402837,"nearGene-5",0,0.23,5e-10,9.30102999566398,null,0.02,"[NR] % increase","Illumina [337,343]","N"]
["V3 (up-regulated)","01/15/2009",19079260,"Thorleifsson G","12/14/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19079260?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.","Body mass index","80,969 individuals","11,036 individuals","11p14.1",11,27667202,"BDNF","- ",null,null,497258,null,null,"rs925946-T","rs925946",0,925946,"intron",0,0.34,9e-10,9.04575749056067,null,3.85,"[2.62-5.08] % SD","Illumina [305,846]","N"]
["V3 (up-regulated)","01/15/2009",19079260,"Thorleifsson G","12/14/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19079260?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.","Body mass index","80,969 individuals","11,036 individuals","11p14.1",11,27679916,"BDNF","- ",null,null,"627;497258",null,null,"rs6265-G","rs6265",0,6265,"missense;ncRNA",0,0.85,5e-10,9.30102999566398,null,4.58,"[3.07-6.09] % SD","Illumina [305,846]","N"]
["V3 (up-regulated)","01/15/2009",19079260,"Thorleifsson G","12/14/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19079260?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.","Body mass index","80,969 individuals","11,036 individuals","11p14.1",11,27583129,"BDNF","- ",null,null,497258,null,null,"rs7481311-T","rs7481311",0,7481311,"intron",0,0.24,8e-06,5.09691001300805,null,3.15,"[1.78-4.52] % SD","Illumina [305,846]","N"]
["V3 (up-regulated)","01/15/2009",19079260,"Thorleifsson G","12/14/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19079260?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.","Weight","80,969 individuals","11,036 individuals","11p14.1",11,27583129,"BDNF","- ",null,null,497258,null,null,"rs7481311-T","rs7481311",0,7481311,"intron",0,0.24,3e-06,5.52287874528033,null,3.5,"[2.03-4.97] % SD","Illumina [305,846]","N"]
["V3 (up-regulated)","01/15/2009",19079260,"Thorleifsson G","12/14/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19079260?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.","Weight","80,969 individuals","11,036 individuals","11p14.1",11,27679916,"BDNF","- ",null,null,"627;497258",null,null,"rs6265-G","rs6265",0,6265,"missense;ncRNA",0,0.85,2e-07,6.69897000433601,null,4,"[2.47-5.53] % SD","Illumina [305,846]","N"]
["V3 (up-regulated)","01/15/2009",19079260,"Thorleifsson G","12/14/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19079260?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.","Weight","80,969 individuals","11,036 individuals","11p14.1",11,27667202,"BDNF","- ",null,null,497258,null,null,"rs925946-T","rs925946",0,925946,"intron",0,0.34,4e-09,8.39794000867203,null,3.8,"[2.55-5.05] % SD","Illumina [305,846]","N"]
["V3 (up-regulated)","01/12/2009",19060910,"Sabatti C","12/07/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19060910?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.","Metabolic traits","4,763 individuals","NR","2q31.1",2,169763148,"G6PC2, ABCB11","- ",null,null,57818,null,null,"rs560887-A","rs560887",0,560887,"intron",0,0.31,6e-10,9.22184874961635,"(GLU)",0.06,"[0.04-0.07] mmol/l decrease","Illumina [329,091]","N"]
["V3 (up-regulated)","02/26/2009",19060907,"Prokopenko I","12/01/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19060907?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Variants in MTNR1B influence fasting glucose levels.","Fasting plasma glucose","35,812 individuals","NR","2q31.1",2,169763148,"G6PC2","- ",null,null,57818,null,null,"rs560887-C","rs560887",0,560887,"intron",0,0.7,1e-57,56.9999999999999,null,0.06,"[0.05-0.07] mmol/l increase","Affymetrix, Illumina and Perlegen [ (up-regulated) to 2,557,249] (imputed)","N"]
["V3 (up-regulated)","01/16/2009",19010793,"Baranzini SE","11/14/2008","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19010793?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.","Normalized brain volume","753 cases,883 controls","NR","5q35.1",5,169950394,"KCNIP1","- ",null,null,30820,null,null,"rs11957313-?","rs11957313",0,11957313,"intron",0,0.13,9e-06,5.04575749056067,null,"NR","NR","Illumina[551,642]","N"]
["V3 (up-regulated)","01/16/2009",19010793,"Baranzini SE","11/14/2008","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19010793?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.","Normalized brain volume","753 cases,883 controls","NR","6q21",6,108916573,"FOXO3","- ",null,null,2309,null,null,"rs9480865-?","rs9480865",0,9480865,"intron",0,0.16,7e-06,5.15490195998574,null,"NR","NR","Illumina[551,642]","N"]
["V3 (up-regulated)","12/09/2008",18951430,"Anney RJ","10/24/2008","Am J Med Genet B Neuropsychiatr Genet","http://www.ncbi.nlm.nih.gov/pubmed/18951430?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.","Attention deficit hyperactivity disorder and conduct disorder","938 affected trios","NR","9p24.1",9,8235633,"PTPRD",null,90871,100127999,null,435.83,477.64,"rs10815798-A","rs10815798",0,10815798,null,1,0.48,6e-06,5.22184874961635,null,"NR","NR","Perlegen[378,332]","N"]
["V3 (up-regulated)","05/07/2009",18839057,"Lesch KP","10/07/2008","J Neural Transm","http://www.ncbi.nlm.nih.gov/pubmed/18839057?ordinalpos=16&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.","Attention deficit hyperactivity disorder","343 cases, 304 controls","NR","3p22.1",3,39555580,"MOBP","- ",null,null,4336,null,null,"rs864643-?","rs864643",0,864643,"intron",0,"NR",1e-08,8,null,"NR","NR","Affymetrix [504,219](pooled)","N"]
["V3 (up-regulated)","05/07/2009",18839057,"Lesch KP","10/07/2008","J Neural Transm","http://www.ncbi.nlm.nih.gov/pubmed/18839057?ordinalpos=16&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.","Attention deficit hyperactivity disorder","343 cases, 304 controls","NR","9q33.1",9,119333683,"ASTN2","- ",null,null,23245,null,null,"rs10983238-?","rs10983238",0,10983238,"intron",0,"NR",1e-07,7,null,"NR","NR","Affymetrix [504,219](pooled)","N"]
["V3 (up-regulated)","11/25/2008",18758461,"Di Bernardo MC","08/31/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18758461?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.","Chronic lymphocytic leukemia","505 cases, 1,438 controls","1,024 cases,1,677 controls","6p25.3",6,411064,"IRF4","- ",null,null,3662,null,null,"rs872071-G","rs872071",0,872071,"ncRNA",0,0.54,2e-20,19.698970004336,null,1.54,"[1.41- 1.69] ","Illumina[345,665]","N"]
["V3 (up-regulated)","11/25/2008",18711365,"Ferreira MA","08/17/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18711365?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Collaborative genome-wide association analysis s (up-regulated)ports a role for ANK3 and CACNA1C in bipolar disorder.","Bipolar disorder","4,387 cases,6,209 controls","NR","10q21.2",10,62179812,"ANK3","- ",null,null,288,null,null,"rs10994336-T","rs10994336",0,10994336,"intron",0,0.05,9e-09,8.04575749056067,null,1.45,"[NR] ","Affymetrix[1,769,948]imputed","N"]
["V3 (up-regulated)","11/25/2008",19165918,"Graham RR","08/01/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19165918","Genetic variants near TNFAIP3 on 6q23 are associated with systemic l (up-regulated)us erythematosus.","Systemic l (up-regulated)us erythematosus","431 cases,2,155 controls","740 trios","6q23.3",6,138195723,"TNFAIP3","- ",null,null,7128,null,null,"rs5029939-?","rs5029939",0,5029939,"intron",0,0.03,3e-12,11.5228787452803,null,2.28,"[NR] ","Affymetrix[313,238]","N"]
["V3 (up-regulated)","11/25/2008",18660810,"Schormair B","07/27/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18660810?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome.","Restless legs syndrome","628 cases,1,644 controls","1,835 cases,3,111 controls","9p24.1",9,8846955,"PTPRD","- ",null,null,5789,null,null,"rs1975197-T","rs1975197",0,1975197,"intron",0,0.16,6e-09,8.22184874961635,null,1.31,"[1.20-1.44] ","Affymetrix[208,733]","N"]
["V3 (up-regulated)","11/25/2008",18660810,"Schormair B","07/27/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18660810?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome.","Restless legs syndrome","628 cases,1,644 controls","1,835 cases,3,111 controls","9p23",9,9261737,"PTPRD","- ",null,null,5789,null,null,"rs4626664-A","rs4626664",0,4626664,"intron",0,0.12,6e-10,9.22184874961635,null,1.44,"[1.31-1.59] ","Affymetrix[208,733]","N"]
["V3 (up-regulated)","11/25/2008",18451265,"Bouatia-Naji N","06/19/2008","Science","http://www.ncbi.nlm.nih.gov/pubmed/18451265?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels.","Fasting plasma glucose","654 normoglycemic individuals","9,353 individuals","2q31.1",2,169763148,"G6PC2","- ",null,null,57818,null,null,"rs560887-A","rs560887",0,560887,"intron",0,0.3,4e-23,22.397940008672,null,0.06,"[0.05-0.08] mmol/l decrease","Illumina[392,935]","N"]
["V3 (up-regulated)","11/25/2008",18535201,"Cooper GM","06/05/2008","Blood","http://www.ncbi.nlm.nih.gov/pubmed/18535201?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose.","Warfarin maintenance dose","181 individuals","374 individuals","10q23.33",10,96707202,"CYP2C9","- ",null,null,1559,null,null,"rs4086116-?","rs4086116",0,4086116,"intron",0,"NR",6e-12,11.2218487496163,null,"NR","NR","Illumina[538,629]","N"]
["V3 (up-regulated)","11/25/2008",18521185,"Chen WM","06/04/2008","J Clin Invest","http://www.ncbi.nlm.nih.gov/pubmed/18521185?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.","Fasting plasma glucose","5,088 nondiabetic individuals","18,436 nondiabetic individuals","2q31.1",2,169774071,"G6PC2,ABCB11",null,57818,8647,null,7.56,5.38,"rs563694-C","rs563694",0,563694,null,1,0.34,4e-07,6.39794000867203,null,"NR","NR","Illumina[315,635]","N"]
["V3 (up-regulated)","11/25/2008",18483556,"Han J","05/16/2008","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/18483556?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.","Black vs. blond hair color","2,287 women"," (up-regulated) to 8,465 individuals","6p25.3",6,396321,"IRF4","- ",null,null,3662,null,null,"rs12203592-T","rs12203592",0,12203592,"intron",0,"NR",7e-127,126.154901959985,null,0.35,"[0.33-0.37] decrease in hair color score","Illumina[528,173]","N"]
["V3 (up-regulated)","11/25/2008",18483556,"Han J","05/16/2008","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/18483556?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.","Black vs. red hair color","2,287 women"," (up-regulated) to 8,465 individuals","6p25.3",6,396321,"IRF4","- ",null,null,3662,null,null,"rs12203592-T","rs12203592",0,12203592,"intron",0,"NR",9e-28,27.0457574905606,null,0.31,"[0.25-0.36] decrease in hair color score","Illumina[528,173]","N"]
["V3 (up-regulated)","11/25/2008",18464913,"Melzer D","05/09/2008","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/18464913?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association study identifies protein quantitative trait loci (pQTLs).","Protein quantitative trait loci","1,200 individuals","NR","1q21.3",1,154426264,"IL6R","- ",null,null,3570,null,null,"rs4129267-?","rs4129267",0,4129267,"intron",0,0.37,2e-57,56.698970004336,"(sIL-6R)","NR","NR","Illumina[496,032]","N"]
["V3 (up-regulated)","11/25/2008",18464913,"Melzer D","05/09/2008","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/18464913?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association study identifies protein quantitative trait loci (pQTLs).","Protein quantitative trait loci","1,200 individuals","NR","2q13",2,113832312,"IL1RN","- ",null,null,84639,null,null,"rs6761276-?","rs6761276",0,6761276,"missense",0,0.37,7e-06,5.15490195998574,"(IL1RA)","NR","NR","Illumina[496,032]","N"]
["V3 (up-regulated)","11/25/2008",18439548,"Ridker PM","04/24/2008","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/18439548?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.","C-reactive protein","6,345 women","NR","1q21.3",1,154426970,"IL6R","- ",null,null,3570,null,null,"rs8192284-?","rs8192284",1,2228145,"missense",0,"NR",2e-08,7.69897000433601,null,0.1,"[NR] mg/dl decrease","Illumina[336,108]","N"]
["V3 (up-regulated)","11/25/2008",18311140,"Hunt KA","03/02/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18311140?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Newly identified genetic risk variants for celiac disease related to the immune response.","Celiac disease","767 cases,1,422 controls","1,643 cases,3,406 controls","2q12.1",2,102971865,"IL1RL1,IL18R1,IL18RAP, SLC9A4",null,9173,8809,null,3.37,7.23,"rs13015714-C","rs13015714",0,13015714,null,1,"NR",4e-09,8.39794000867203,null,1.28,"[1.18-1.39] ","Illumina[310,605]","N"]
["V3 (up-regulated)","11/25/2008",18311140,"Hunt KA","03/02/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18311140?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Newly identified genetic risk variants for celiac disease related to the immune response.","Celiac disease","767 cases,1,422 controls","1,643 cases,3,406 controls","4q27",4,123509421,"KIAA1109, ADAD1, IL2, IL21",null,3558,59067,null,131.77,24.36,"rs6822844-C","rs6822844",0,6822844,null,1,0.81,3e-13,12.5228787452803,null,1.44,"[1.30-1.58] ","Illumina[310,605]","N"]
["V3 (up-regulated)","11/25/2008",17982456,"Plenge RM","11/04/2007","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/17982456?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.","Rheumatoid arthritis","397 cases,1,211 Framingham individuals","2,283 cases,3,258 controls","6q23.3",6,138002637,"TNFAIP3, OLIG3",null,391040,7128,null,137.06,185.69,"rs10499194-C","rs10499194",0,10499194,null,1,0.71,1e-09,8.99999999999999,null,1.33,"[1.15-1.52] ","Affymetrix[79,853]","N"]
["V3 (up-regulated)","11/25/2008",17982456,"Plenge RM","11/04/2007","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/17982456?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.","Rheumatoid arthritis","397 cases,1,211 Framingham individuals","2,283 cases,3,258 controls","6q23.3",6,138006504,"TNFAIP3, OLIG3",null,391040,7128,null,140.92,181.82,"rs6920220-?","rs6920220",0,6920220,null,1,0.2,1e-07,7,null,1.22,"[NR] ","Affymetrix[79,853]","N"]
["V3 (up-regulated)","11/25/2008",17952075,"Sulem P","10/21/2007","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/17952075?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genetic determinants of hair, eye and skin pigmentation in Europeans.","Freckles","2,986 individuals","3,932 individuals","6p25.3",6,466033,"SEC5L1,IRF4",null,3662,55770,null,54.59,19.11,"rs1540771-A","rs1540771",0,1540771,null,1,0.42,4e-18,17.397940008672,null,1.4,"[1.26-1.57] ","Illumina[317,511]","N"]
["V3 (up-regulated)","11/25/2008",17903307,"Wilk JB","09/19/2007","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/17903307?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Framingham Heart Study genome-wide association: results for pulmonary function measures.","Pulmonary function"," (up-regulated) to 1,222 individuals","NR","1q21.3",1,154426264,"IL6R","- ",null,null,3570,null,null,"rs4129267-?","rs4129267",0,4129267,"intron",0,"NR",7e-06,5.15490195998574,"(ppFEF)","NR","NR","Affymetrix[70,897]","N"]
["V3 (up-regulated)","11/25/2008",17903294,"Yang Q","09/19/2007","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/17903294?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study.","Factor VII","1,000 individuals(Framingham)","NR","13q34",13,113760034,"MCF2L, AB116074, AK092739, AK123267, AB002360, F7, CR603372, F10, PROZ","- ",null,null,2155,null,null,"rs561241-?","rs561241",0,561241,"nearGene-5",0,0.12,5e-16,15.3010299956639,null,"NR","NR","Affymetrix[70,897]","N"]
["V3 (up-regulated)","11/25/2008",17558408,"van Heel DA","06/10/2007","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/17558408?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.","Celiac disease","778 cases,1,422 controls","991 cases,1,489 controls","4q27",4,123509421,"KIAA1109,TENR,IL2,IL21",null,3558,59067,null,131.77,24.36,"rs6822844-G","rs6822844",0,6822844,null,1,0.82,1e-14,14,null,1.59,"[1.41-1.75] ","Illumina[310,605]","N"]
["V3 (down-regulated)","06/13/2013",23472185,"Mero IL","03/05/2013","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23472185","Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles.","Multiple sclerosis (OCB status)","1,367 European ancestry OCB positive cases, 161 European ancestry OCB negative cases, 428 European ancestry controls",null,"6p21.32",6,32592200,"HLA-DQA1",null,3123,3117,null,34.59,12.98,"rs9271640-?","rs9271640",0,9271640,null,1,"NR",2e-20,19.698970004336,"(OCB positive vs. controls)",2.37,"[1.97-2.84] ","Illumina [495,970]","N"]
["V3 (down-regulated)","05/11/2013",23400010,"Del-Aguila JL","02/12/2013","Pharmacogenomics J","http://www.ncbi.nlm.nih.gov/pubmed/23400010","Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.","Thiazide-induced adverse metabolic effects in hypertensive patients","425 European ancestry cases, 342 African American cases","NR","16q24.1",16,85906616,"COX4I1",null,401863,3394,null,56.44,26.16,"rs11648716-G","rs11648716",0,11648716,null,1,0.08,7e-06,5.15490195998574,"(EA-triglyceride response)",39.68,"[22.37-56.99] mg/dL decrease","Illumina and Affymetrics [>2 million] (Imputed)","N"]
["V3 (down-regulated)","05/09/2013",23377640,"GENDEP Investigators","02/01/2013","Am J Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23377640 ","Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.","Major depressive disorder"," (up-regulated) to 2,256 European ancestry cases","NR","19q13.11",19,33089431,"PDCD5,ANKRD27,RGS9BP,NUDT19","- ",null,null,84079,null,null,"rs17692896-A","rs17692896",0,17692896,"intron",0,0.0739179,7e-07,6.15490195998574,"(% improvement - SSRI treated - 2 weeks)",0.44,"[0.27-0.61] unit decrease","Illumina & Affymetrix [1.2 million] (Imputed)","N"]
["V3 (down-regulated)","05/09/2013",23378610,"Xie W","02/01/2013","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/23378610 ","Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.","Metabolite levels","1,004 European ancestry individuals","339 European ancestry individuals","1p12",1,120255126,"PHGDH","- ",null,null,26227,null,null,"rs478093-G","rs478093",0,478093,"intron",0,0.71,2e-14,13.698970004336,"(serine)","NR","NR","Affymetrix [909,508] (imputed)","N"]
["V3 (down-regulated)","06/06/2013",23362303,"Wu JH","01/29/2013","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/23362303 ","Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.","Palmitoleic acid (16:1n-7) plasma levels","8,961 European ancestry individuals",null,"10q24.31",10,102302457,"HIF1AN, SEC31B, NDUFB8, WNT8B, SCD ","- ",null,null,55662,null,null,"rs11190604-A ","rs11190604 ",0,11190604,"intron",0,0.782,6e-09,8.22184874961635,null,0.02,"unit decrease ","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (down-regulated)","04/17/2013",23349640,"Vijai J","01/17/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23349640","Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies.","Lymphoma","275 Follicular non-Hodgkin抯 Lymphoma cases, 269 diffuse large B-cell non-Hodgkin抯 Lymphoma cases, 198 other non-Hodgkin抯 Lymphoma cases, 202 Hodgkin抯 Lymphoma cases, 4,044 controls","202 European ancestry Follicular non-Hodgkin抯 Lymphoma cases, 367 European ancestry diffuse large B-cell non-Hodgkin抯 Lymphoma cases, 577 European ancestry other non-Hodgkin抯 Lymphoma cases, 99 European ancestry Hodgkin抯 Lymphoma cases, 2,596 European ancestry controls","6p21.32",6,32581889,"HLA-DRB5, HLA-DQA1",null,3123,3117,null,24.28,23.29,"rs4530903-T","rs4530903",0,4530903,null,1,"NR",3e-12,11.5228787452803,"(FL)",1.93,"[NR] ","Affymetrix [530,583]","N"]
["V3 (down-regulated)","04/17/2013",23349640,"Vijai J","01/17/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23349640","Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies.","Lymphoma","275 Follicular non-Hodgkin抯 Lymphoma cases, 269 diffuse large B-cell non-Hodgkin抯 Lymphoma cases, 198 other non-Hodgkin抯 Lymphoma cases, 202 Hodgkin抯 Lymphoma cases, 4,044 controls","202 European ancestry Follicular non-Hodgkin抯 Lymphoma cases, 367 European ancestry diffuse large B-cell non-Hodgkin抯 Lymphoma cases, 577 European ancestry other non-Hodgkin抯 Lymphoma cases, 99 European ancestry Hodgkin抯 Lymphoma cases, 2,596 European ancestry controls","6p21.32",6,32581889,"HLA-DRB5, HLA-DQA1",null,3123,3117,null,24.28,23.29,"rs4530903-T","rs4530903",0,4530903,null,1,"NR",3e-06,5.52287874528033,"(LYM)",1.29,"[1.16-1.43] ","Affymetrix [530,583]","N"]
["V3 (down-regulated)","04/17/2013",23349640,"Vijai J","01/17/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23349640","Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies.","Lymphoma","275 Follicular non-Hodgkin抯 Lymphoma cases, 269 diffuse large B-cell non-Hodgkin抯 Lymphoma cases, 198 other non-Hodgkin抯 Lymphoma cases, 202 Hodgkin抯 Lymphoma cases, 4,044 controls","202 European ancestry Follicular non-Hodgkin抯 Lymphoma cases, 367 European ancestry diffuse large B-cell non-Hodgkin抯 Lymphoma cases, 577 European ancestry other non-Hodgkin抯 Lymphoma cases, 99 European ancestry Hodgkin抯 Lymphoma cases, 2,596 European ancestry controls","6p21.32",6,32581889,"HLA-DRB5, HLA-DQA1",null,3123,3117,null,24.28,23.29,"rs4530903-T","rs4530903",0,4530903,null,1,"NR",2e-08,7.69897000433601,"(NHL)",1.37,"[1.23-1.54] ","Affymetrix [530,583]","N"]
["V3 (down-regulated)","03/26/2013",23319801,"Rafiq S","01/14/2013","Cancer Res","http://www.ncbi.nlm.nih.gov/pubmed/23319801 ","Identification of inherited genetic variations influencing prognosis in early-onset breast cancer.","Breast cancer (prognosis)","536 early-onset cases","1,516 early-onset cases","1q23.3",1,164689762,"PBX1","- ",null,null,5087,null,null,"rs1387389-?","rs1387389",0,1387389,"intron",0,0.36,4e-06,5.39794000867203,null,1.28,"[1.16-1.43] ","Illumina [487,496]","N"]
["V3 (down-regulated)","05/01/2013",23326239,"Rubicz R","01/10/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23326239","A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1).","Epstein-Barr virus immune response (EBNA-1)","1,367 Mexican American indivduals","589 Mexican American indivduals","6p21.32",6,32628428,"HLA-DQB1, C6orf15, PSORS1C1, HLA-B, BAT2, BAT4, EHMT2, PRRT1, NOTCH4, ","- ",null,null,3119,null,null,"rs2854275-T","rs2854275",0,2854275,"intron",0,0.064,2e-10,9.69897000433601,"(Conditional on rs477515 - Quantitative)",0.45,"[NR] unit decrease","Illumina [944,565]","N"]
["V3 (down-regulated)","03/27/2013",23300278,"Saxena R","01/08/2013","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/23300278 ","Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.","Type 2 diabetes","842 Punjabi Sikh cases, 774 Punjabi Sikh controls"," (up-regulated) to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls;  (up-regulated) to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls;  (up-regulated) to 13,559 other South Asian cases and 20,822 other South Asian controls;  (up-regulated) to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls;  (up-regulated) to 8,130 European ancestry cases and 38,987 European ancestry controls","17p13.3",17,700020,"NXN",null,55178,64359,null,4.28,2.53,"rs623323-T","rs623323",0,623323,null,1,0.15,4e-06,5.39794000867203,"(Punjabi Sikhs)",1.28,"[1.15 - 1.42] ","Illumina [1,232,008] (imputed)","N"]
["V3 (down-regulated)","03/21/2013",23291585,"LeishGEN Consortium","01/06/2013","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23291585","Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis.","Leishmaniasis (visceral)","889 Indian ancestry cases, 977 Indian ancestry controls, 357 Brazilian ancestry cases, and 1,615 Brazilian ancestry unaffected relatives","889 Indian ancestry cases, 948 Indian ancestry controls.","6p21.32",6,32595223,"HLA-DRB1, HLA-DQA1, HLA",null,3123,3117,null,37.61,9.96,"rs9271858-G","rs9271858",0,9271858,null,1,0.39,3e-17,16.5228787452803,null,1.41,"[1.30-1.52] ","Illumina [521,134]","N"]
["V3 (down-regulated)","02/21/2013",23273568,"Yang W","12/27/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23273568","Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic l (up-regulated)us erythematosus in Asians.","Systemic l (up-regulated)us erythematosus","1,656 Han Chinese cases, 3,394 Han Chinese controls","3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls","2p13.1",2,74208362,"TET3, DGUOK","- ",null,null,100874048,null,null,"rs6705628-C","rs6705628",0,6705628,"ncRNA",0,0.78,7e-17,16.1549019599857,null,1.33,null,"Illumina [2,100,739] (imputed)","N"]
["V3 (down-regulated)","02/21/2013",23273568,"Yang W","12/27/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23273568","Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic l (up-regulated)us erythematosus in Asians.","Systemic l (up-regulated)us erythematosus","1,656 Han Chinese cases, 3,394 Han Chinese controls","3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls","2p13.1",2,74202578,"TET3, DGUOK","- ",null,null,100874048,null,null,"rs4852324-T","rs4852324",0,4852324,"intron",0,0.76,6e-14,13.2218487496163,null,1.27,null,"Illumina [2,100,739] (imputed)","N"]
["V3 (down-regulated)","02/27/2013",23266558,"Yamazaki K","12/21/2012","Gastroenterology","http://www.ncbi.nlm.nih.gov/pubmed/23266558","A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.","Crohn's disease","372 Japanese ancestry cases and 3,389 Japanese ancestry controls"," (up-regulated) to 1,151 Japanese ancestry cases and  (up-regulated) to 15,800 Japanese ancestry controls","6p21.32",6,32680928,"HLA-DQA2, HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DOB, PSMB9",null,404026,3118,null,6.35,28.24,"rs7765379-G","rs7765379",0,7765379,null,1,"NR",9e-59,58.0457574905606,null,1.93,"[1.78-2.09] ","Illumina [4,929,034] (imputed)","N"]
["V3 (down-regulated)","02/27/2013",23284291,"Hancock DB","12/20/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23284291 ","Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.","Pulmonary function (interaction)","50,047 European ancestry individuals","NR","9q33.1",9,119314217,"ASTN2","- ",null,null,"23245;100128505",null,null,"rs13290997-A ","rs13290997   ",0,13290997,"intron;intron",0,"NR",5e-07,6.30102999566398,"(FEV1, Pack-years)","NR","NR","NR [~2.5 Million] (imputed)","N"]
["V3 (down-regulated)","03/19/2013",23222517,"van der Harst P","12/05/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23222517","Seventy-five genetic loci influencing the human red blood cell.","Red blood cell traits","62,553 European ancestry individuals, 9,308 South Asian ancestry individuals","63,506 European ancestry individuals","22q13.33",22,50971266,"ODF3B, TYMP, NCAPH2, SCO2","- ",null,null,440836,null,null,"rs140522-C","rs140522",0,140522,"nearGene-5",0,0.67,5e-23,22.3010299956639,"(EA, MCV)",0.29,"[0.23-0.35] unit increase","Illumina, Affymetrix & Perlegen [2,711,806] imputed","N"]
["V3 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","2q14.2",2,120145655,"DBI",null,1622,140738,null,15.53,43.79,"rs1374313-G","rs1374313",0,1374313,null,1,0.343,9e-07,6.04575749056067,"(Diet fat )",0.03,"[NR]  g/d increase","Illumina [899,892]","N"]
["V3 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","9q33.1",9,119839328,"ASTN2","- ",null,null,23245,null,null,"rs16934284-G","rs16934284",0,16934284,"intron",0,0.085,2e-06,5.69897000433601,"(AST )",0.03,"[NR]  U/L increase","Illumina [899,892]","N"]
["V3 (down-regulated)","03/05/2013",23181788,"Lasky-Su J","12/04/2012","Clin Exp Allergy","http://www.ncbi.nlm.nih.gov/pubmed/23181788 ","HLA-DQ strikes again: genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults.","Asthma"," (up-regulated) to 1,238 European ancestry cases,  (up-regulated) to 2,617 European ancestry controls "," (up-regulated) to European 1,837 ancestry cases,  (up-regulated) to 3,803 European ancestry controls,  (up-regulated) to 2,806 cases,  (up-regulated) to 2,150 controls,  (up-regulated) to 603 Costa Rican cases and their parents","6p21.32",6,32604372,"HLA-DQA1","- ",null,null,3117,null,null,"rs9272346-?","rs9272346",0,9272346,"nearGene-5",0,"NR",2e-08,7.69897000433601,"(Adult)","NR","NR","Affymetrix (455,089)","N"]
["V3 (down-regulated)","02/20/2013",23212062,"Fanous AH","12/01/2012","Am J Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23212062","Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms.","Schizophrenia","2,454 European ancestry cases","NR","6p21.32",6,32581889,"HLA-DRB1, HLA-DQA1",null,3123,3117,null,24.28,23.29,"rs4530903-?","rs4530903",0,4530903,null,1,"NR",5e-06,5.30102999566398,"(Negative/disorganized symptoms)",0.09,"[NR] unit increase","Affymetrix [696,491]","N"]
["V3 (down-regulated)","01/30/2013",23166209,"Smith JG","11/19/2012","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/23166209","Impact of ancestry and common genetic variants on QT interval in African Americans.","QT interval","13,105 African American individuals","NR","16p13.13",16,11691753,"LITAF",null,9516,8303,null,10.43,70.54,"rs8049607-C","rs8049607",0,8049607,null,1,0.52,7e-07,6.15490195998574,null,1.63,"[0.98-2.28] unit decrease","Affymetrix & Illumina [2.8 million] (imputed)","N"]
["V3 (down-regulated)","01/29/2013",23149075,"Aslibekyan S","11/10/2012","Nutr Metab Cardiovasc Dis","http://www.ncbi.nlm.nih.gov/pubmed/23149075","Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network.","Response to fenofibrate (adiponectin levels)","793 European ancestry individuals","NA","12q24.13",12,113607502,"DDX54, TPCN1, SLC24A6, OAS1, OAS2, OAS3","- ",null,null,79039,null,null,"rs2384207-?","rs2384207",0,2384207,"intron",0,"NR",5e-08,7.30102999566398,"(Response)",0.06,"[0.040-0.080] ng/dL increase","Affymterix [2,543,887] (imputed)","N"]
["V3 (down-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","16p13.13",16,11373320,"SOCS1,LITAF,RMI2",null,5620,5619,null,2.98,1.37,"rs529866-C","rs529866",0,529866,null,1,0.803,2e-16,15.698970004336,null,1.12,"[1.085-1.166] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V3 (down-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Ulcerative colitis"," (up-regulated) to 12,924 European ancestry cases,  (up-regulated) to 21,442 European ancestry controls"," (up-regulated) to 25,683 European ancestry cases,  (up-regulated) to 17,015 European ancestry controls","6p21.32",6,32612397,"HLA-DQB1,HLA-DRB1,HLA-DQA1,HLA-DRA",null,3117,3119,null,0.97,14.84,"rs6927022-A","rs6927022",0,6927022,null,1,0.535,5e-133,132.301029995664,null,1.44,"[1.387-1.503] ","Affymetrix & Illumina [1.23 million] (imputed)","N"]
["V3 (down-regulated)","01/16/2013",23049088,"Meng W","10/09/2012","Invest Ophthalmol Vis Sci","http://www.ncbi.nlm.nih.gov/pubmed/23049088","A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.","Myopia (pathological)","187 European ancestry cases, 1064 European ancestry controls",null,"15q24.1",15,74305966,"PML","- ",null,null,5371,null,null,"rs8039584-?","rs8039584",0,8039584,"intron",0,0.044,5e-08,7.30102999566398,null,"NR","NR","Affymetrix & Illumina [152,234]","N"]
["V3 (down-regulated)","11/05/2012",22952603,"Hart AB","08/28/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/22952603","Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).","Response to amphetamines","1 American Indian ancestry individual, 18 African American/Afro-Caribbean ancestry individuals, 10 East Asian and South Asian ancestry individuals, 325 European ancestry individuals, 17 Latin American ancestry individuals, 6 other ancestry individuals, 4 individuals","NR","9q34.12",9,133748083,"ABL1","- ",null,null,25,null,null,"rs2070997-?","rs2070997",0,2070997,"intron",0,"NR",8e-06,5.09691001300805,"(SF6)","NR","NR","Affymetrix [5,476,100] (imputed)","N"]
["V3 (down-regulated)","10/24/2012",22922875,"Vithana EN","08/26/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22922875","Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma.","Glaucoma (primary open-angle)","984 Singaporean Chinese cases, 943 Singaporean Chinese controls, 297 Han Chinese cases, 1,044 Han Chinese controls, 573 South Asian ancestry cases, 3,065 Singaporean Malay controls, 2,538 Singaporean Asian Indian controls, 2,018 Vietnamese ancestry controls.","309 Singaporean Chinese cases, 1,479 Singaporean Chinese controls, 1,236 Chinese ancestry cases, 2,277 Chinese ancestry controls, 165 Saudi Arabian ancestry cases, 175 Saudi Arabian controls, 127 European ancestry cases, 4,703 European ancestry controls, 80 Indian ancestry cases, 309 Indian ancestry controls","22q11.21",22,19889825,"TXNRD2","- ",null,null,10587,null,null,"rs3788317-?","rs3788317",0,3788317,"intron",0,"NR",2e-07,6.69897000433601,null,1.22,"[NR] ","Illumina [493,501] ","N"]
["V3 (down-regulated)","09/18/2012",22797727,"Okada Y","07/15/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22797727","Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.","Renal function-related traits (BUN)","39,717 Japanese, Korean, and Chinese ancestry individuals","17,461 Japanese and Korean ancestry individuals","1q22",1,155194980,"MTX1, GBA","- ",null,null,2630,null,null,"rs2049805-T","rs2049805",0,2049805,"intron",0,0.17,2e-12,11.698970004336,null,0.01,"[0.0052-0.0092] mg/dl increase","Affymetrix & Illumina [2,281,523] (imputed)","N"]
["V3 (down-regulated)","09/20/2012",22807686,"Li S","07/12/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22807686","GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers.","Hepatocellular carcinoma","1,538 Han Chinese HBV-positive HCC cases, 1,465 Han Chinese chronic HBV carriers  ","4,431 Han Chinese HBV-positive HCC cases, 4,725 Han Chinese  chronic HBV carriers  ","6p21.32",6,32599999,"HLA-DQA1, HLA-DRB1",null,3123,3117,null,42.39,5.18,"rs9272105-A","rs9272105",0,9272105,null,1,0.45,5e-22,21.3010299956639,null,1.28,"[1.22-1.35] ","NR [523,663]","N"]
["V3 (down-regulated)","08/20/2012",22747683,"Eriksson N","06/30/2012","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/22747683","Genetic variants associated with breast size also influence breast cancer risk.","Breast size","16,175 European ancestry women","NR","11q13.3",11,69143284,"IFITM9P, CCND1",null,390218,595,null,72.01,312.59,"rs7102705-A","rs7102705",0,7102705,null,1,0.211,5e-06,5.30102999566398,null,0.09,"[0.049-0.123] c (up-regulated) size increase","Illumina [7,422,970] (imputed)","N"]
["V3 (down-regulated)","08/14/2012",22688191,"Bergen SE","06/12/2012","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22688191","Genome-wide association study in a Swedish population yields s (up-regulated)port for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.","Schizophrenia","2,111 European ancestry schizophrenia cases, 2,535 European ancestry controls","11,271 schizophrenia cases, 14,601 controls","7p22.3",7,2004421,"MAD1L1, SNX8, NUDT1, FTSJ2","- ",null,null,8379,null,null,"rs12666575-?","rs12666575",0,12666575,"intron",0,"NR",2e-09,8.69897000433601,null,1.12,"[NR] ","Affymetrix [745,006]","N"]
["V3 (down-regulated)","08/07/2012",22683712,"Freilinger T","06/10/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22683712","Genome-wide association analysis identifies susceptibility loci for migraine without aura.","Migraine","2,326 European ancestry cases, 4,580 European ancestry controls","2,508 European ancestry cases, 2,652 European ancestry controls","9q33.1",9,119252629,"ASTN2","- ",null,null,23245,null,null,"rs6478241-A","rs6478241",0,6478241,"intron",0,0.38,4e-08,7.39794000867203,null,1.16,"[1.10-1.23] ","Illumina [1,246,388] (imputed)","N"]
["V3 (down-regulated)","07/17/2012",22658931,"Pajewski NM","05/30/2012","Vaccine","http://www.ncbi.nlm.nih.gov/pubmed/22658931","A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed.","Immune response to anthrax vaccine ","726 European ancestry individuals","NR","6p21.32",6,32681676,"HLA-DRB1,HLA-DQA1",null,404026,3118,null,7.1,27.49,"rs3104402-A","rs3104402",0,3104402,null,1,"NR",6e-06,5.22184874961635,null,0.17,"[0.094-0.236] unit decrease","Affymetrix [736,996]","N"]
["V3 (down-regulated)","07/17/2012",22658931,"Pajewski NM","05/30/2012","Vaccine","http://www.ncbi.nlm.nih.gov/pubmed/22658931","A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed.","Immune response to anthrax vaccine ","726 European ancestry individuals","NR","9q33.1",9,119925095,"ASTN2","- ",null,null,23245,null,null,"rs6478282-A","rs6478282",0,6478282,"intron",0,"NR",6e-06,5.22184874961635,null,0.1,"[0.058-0.144] unit increase","Affymetrix [736,996]","N"]
["V3 (down-regulated)","07/31/2012",22745009,"Melville SA","05/15/2012","Ann Neurol","http://www.ncbi.nlm.nih.gov/pubmed/22745009","Multiple loci influencing hippocampal degeneration identified by genome scan.","Hippocampal atrophy","1149 European ancestry Alzheimer disease cases, 336 European ancestry individuals with mild cognitive impairment, 188 European ancestry controls","419 African American Alzheimer disease cases","2q31.1",2,172127920,"METTL8",null,9874,644166,null,40.1,103.43,"rs4667682-C","rs4667682",0,4667682,null,1,0.82,5e-06,5.30102999566398,"(White matter hyperintensities)","NR","NR","Illumina [2,131,250] (imputed)","N"]
["V3 (down-regulated)","08/15/2012",22581228,"Manning AK","05/13/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22581228","A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.","Fasting glucose-related traits (interaction with BMI)"," (up-regulated) to 58,074 European ancestry individuals"," (up-regulated) tp 38,422 European ancestry individuals","15q22.2",15,62396942,"VPS13C",null,145741,388125,null,33.83,58.8,"rs7173964-?","rs7173964",0,7173964,null,1,"NR",6e-12,11.2218487496163,null,"NR","NR","Affymetrix & Illumina [~2.4 million] (imputed)","N"]
["V3 (down-regulated)","08/17/2012",22589738,"Fox CS","05/10/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22589738","Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.","Subcutaneous adipose tissue","5,560 European ancestry women and 4,997 European ancestry men","NR","19q13.32",19,46195756,"QPCTL, FBXO46, EML2, SNRPD2, GIPR","- ",null,null,"6633;54814",null,null,"rs7245708-C","rs7245708",0,7245708,"nearGene-5;UTR-5",0,0.04,1e-06,5.99999999999999,"(women)","NR","NR","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V3 (down-regulated)","08/17/2012",22589738,"Fox CS","05/10/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22589738","Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.","Subcutaneous adipose tissue","5,560 European ancestry women and 4,997 European ancestry men","NR","19q13.32",19,46195756,"QPTCL, FBXO46, EML2, SNRPD2, GIPR","- ",null,null,"6633;54814",null,null,"rs7245708-C","rs7245708",0,7245708,"nearGene-5;UTR-5",0,0.04,2e-06,5.69897000433601,"(overall)","NR","NR","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V3 (down-regulated)","08/17/2012",22589738,"Fox CS","05/10/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22589738","Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.","Visceral adipose tissue adjusted for BMI","5,560 European ancestry women and 4,997 European ancestry men","NR","12q24.13",12,113491784,"DTX1, OAS2, RASAL1",null,4939,100271649,null,42.26,0.08,"rs7956193-T","rs7956193",0,7956193,null,1,0.29,1e-06,5.99999999999999,"(women)","NR","NR","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V3 (down-regulated)","08/17/2012",22589738,"Fox CS","05/10/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22589738","Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.","Visceral adipose tissue/subcutaneous adipose tissue ratio","5,560 European ancestry women and 4,997 European ancestry men","NR","4q35.1",4,186612675,"SORBS2","- ",null,null,8470,null,null,"rs4376189-A","rs4376189",0,4376189,"intron",0,0.9,2e-06,5.69897000433601,"(overall)","NR","NR","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V3 (down-regulated)","08/14/2012",22566634,"Benjamin DJ","05/07/2012","Proc Natl Acad Sci U S A","http://www.ncbi.nlm.nih.gov/pubmed/22566634","The genetic architecture of economic and political preferences.","Economic and political preferences","9,617 individuals","NR","17p13.3",17,831667,"NXN","- ",null,null,64359,null,null,"rs2360111-T","rs2360111",0,2360111,"intron",0,"NR",3e-06,5.52287874528033,"(Economic policy)",0.11,"[0.066-0.16] unit decrease","Illumina [628,922]","N"]
["V3 (down-regulated)","08/14/2012",22566634,"Benjamin DJ","05/07/2012","Proc Natl Acad Sci U S A","http://www.ncbi.nlm.nih.gov/pubmed/22566634","The genetic architecture of economic and political preferences.","Economic and political preferences (environmentalism)","9,617 individuals","NR","6p21.33",6,31867253,"EHMT2","- ",null,null,"717;10919;221527",null,null,"rs9267663-T","rs9267663",0,9267663,"intron;nearGene-5;nearGene-3",0,"NR",6e-06,5.22184874961635,null,0.29,"[0.16-0.42] unit decrease","Illumina [628,922]","N"]
["V3 (down-regulated)","08/14/2012",22566634,"Benjamin DJ","05/07/2012","Proc Natl Acad Sci U S A","http://www.ncbi.nlm.nih.gov/pubmed/22566634","The genetic architecture of economic and political preferences.","Economic and political preferences (fairness)","9,617 individuals","NR","9q33.1",9,120137758,"ASTN2","- ",null,null,23245,null,null,"rs2226006-T","rs2226006",0,2226006,"intron",0,"NR",6e-06,5.22184874961635,null,0.11,"[0.062-0.160] unit decrease","Illumina [628,922]","N"]
["V3 (down-regulated)","06/02/2012",22504421,"Bis JC","04/15/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22504421","Common variants at 12q14 and 12q24 are associated with hippocampal volume.","Hippocampal volume","9,232 European ancestry individuals","2,318 European ancestry individuals","9q33.1",9,119249339,"ASTN2","- ",null,null,23245,null,null,"rs7852872-C","rs7852872",0,7852872,"intron",0,0.62,1e-07,7,null,47.7,"[30.06-65.34] mm3 decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (down-regulated)","04/11/2013",22504420,"Estrada K","04/15/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22504420","Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.","Bone mineral density"," (up-regulated) to 32,961 European and East Asian ancestry individuals"," (up-regulated) to 50,933 European and East Asian ancestry individuals","7q21.3",7,96120675,"SLC25A13","- ",null,null,401388,null,null,"rs4727338-C","rs4727338",0,4727338,"intron",0,0.67,8e-48,47.096910013008,"(FNBMD)",0.08,"[NR] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (down-regulated)","05/25/2012",22493691,"Eriksson N","04/06/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/22493691","Novel associations for hypothyroidism include known autoimmune risk loci.","Hypothyroidism","3,736 European ancestry cases, 35,546 European ancestry controls","NR","6p21.32",6,32663631,"HLA-DRB9, HLA-DRB5, HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DQA2",null,3119,404026,null,29.17,10.29,"rs3129720-C","rs3129720",0,3129720,null,1,0.764,5e-07,6.30102999566398,null,1.16,"(1.10-1.23) ","Illumina [870,065]","N"]
["V3 (down-regulated)","05/11/2012",22472876,"Major Depressive Disorder Working Gro (up-regulated) of the Psychiatric GWAS Consortium","04/03/2012","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22472876","A mega-analysis of genome-wide association studies for major depressive disorder.","Major depressive disorder","9,240 European ancestry cases, 9,519 European ancestry controls","6,783 European ancestry cases, 50,695 European ancestry controls","3q27.1",3,183876512,"HTR3D,HTR3C,HTR3E,EIF2B5,DVL3,AP2M1,ABCF3,VWA5B2,MIR1224,ALG3,ECE2,CAMK2N2","- ",null,null,1857,null,null,"rs1969253-?","rs1969253",0,1969253,"intron",0,"NR",5e-06,5.30102999566398,null,"NR","NR","Affymetrix, Illumina & Perlegen [~1.2 million](imputed)","N"]
["V3 (down-regulated)","05/11/2012",22472876,"Major Depressive Disorder Working Gro (up-regulated) of the Psychiatric GWAS Consortium","04/03/2012","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22472876","A mega-analysis of genome-wide association studies for major depressive disorder.","Major depressive disorder","9,240 European ancestry cases, 9,519 European ancestry controls","6,783 European ancestry cases, 50,695 European ancestry controls","16q24.2",16,87461969,"FBXO31,MAP1LC3B,ZCCHC14","- ",null,null,23174,null,null,"rs9646303-?","rs9646303",0,9646303,"intron",0,"NR",5e-06,5.30102999566398,null,"NR","NR","Affymetrix, Illumina & Perlegen [~1.2 million](imputed)","N"]
["V3 (down-regulated)","04/03/2012",22412388,"Kenny EE","03/08/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22412388","A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.","Crohn's disease","737 Ashkenazi Jewish cases, 2,257  Ashkenazi Jewish controls","971 Ashkenazi Jewish cases, 2,124 Ashkenazi Jewish controls","16q22.1",16,67971380,"PSMB10","- ",null,null,5699,null,null,"rs11574514-A","rs11574514",0,11574514,"nearGene-5",0,0.045,2e-07,6.69897000433601,null,1.44,"[1.35-1.52] ","Affyemtrix & Illumina [1,060,934] (imputed)","N"]
["V3 (down-regulated)","12/15/2011",22080838,"Cho MH","11/11/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/22080838","A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.","Chronic obstructive pulmonary disease","3,499 European ancestry cases, 1,922 European ancestry controls","983 probands, 1,876 siblings","19q13.2",19,41302706,"RAB4B, EGLN2, CYP2A6","- ",null,null,"53916;100529262;100529264",null,null,"rs7937-?","rs7937",0,7937,"UTR-3;ncRNA;intron",0,"NR",3e-09,8.52287874528033,null,1.37,"[1.20-1.59] ","Illumina [797,983]","N"]
["V3 (down-regulated)","12/02/2011",22041458,"Clark SL","11/01/2011","Psychol Med","http://www.ncbi.nlm.nih.gov/pubmed/22041458","Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.","Response to antidepressant treatment","1,439 non-psychotic major depressive disorder cases","NR","15q21.2",15,49939846,"DTWD1",null,56986,645453,null,2.51,146.6,"rs8039808-A","rs8039808",0,8039808,null,1,0.06,5e-07,6.30102999566398,"(Citalopram+Buspirone, Dizziness)","NR","NR","Affymetrix [421,789]","N"]
["V3 (down-regulated)","12/01/2011",22036096,"Ramasamy A","11/01/2011","J Allergy Clin Immunol","http://www.ncbi.nlm.nih.gov/pubmed/22036096","A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.","IgE grass sensitization","2,315 Caucasian cases, 10,032 Caucasian controls","NR","1p32.3",1,51859242,"EPS15","- ",null,null,2060,null,null,"rs6673480-T","rs6673480",0,6673480,"intron",0,0.07,2e-06,5.69897000433601,null,1.35,"[1.19-1.52] ","Affymetrix & Illumina [2,217,510] (imputed)","N"]
["V3 (down-regulated)","11/18/2011",22001757,"Chambers JC","10/16/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22001757","Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.","Liver enzyme levels (alkaline phosphatase)"," (up-regulated) to 52,350 European ancestry individuals,  (up-regulated) to 8,739 Indian Asian individuals","NR","20p11.21",20,25298087,"ABHD12,GINS1, PYGB","- ",null,null,26090,null,null,"rs7267979-G","rs7267979",0,7267979,"intron",0,0.57,7e-10,9.15490195998574,null,1.5,"[0.90-2.0] % increase","Affymetrix, Illumina, and Perlegen [~2.6 million] (imputed)","N"]
["V3 (down-regulated)","11/18/2011",22001757,"Chambers JC","10/16/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22001757","Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.","Liver enzyme levels (gamma-glutamyl transferase)"," (up-regulated) to 52,350 European ancestry individuals,  (up-regulated) to 8,739 Indian Asian individuals","NR","1q22",1,155126948,"DPM3, EFNA1, PKLR",null,648822,200185,null,4.19,14.94,"rs10908458-T","rs10908458",0,10908458,null,1,0.58,2e-15,14.698970004336,null,3.7,"[3.10-4.20] % increase","Affymetrix, Illumina, and Perlegen [~2.6 million] (imputed)","N"]
["V3 (down-regulated)","11/18/2011",22001757,"Chambers JC","10/16/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22001757","Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.","Liver enzyme levels (gamma-glutamyl transferase)"," (up-regulated) to 52,350 European ancestry individuals,  (up-regulated) to 8,739 Indian Asian individuals","NR","22q11.23",22,24295286,"DDT, DDTL, GSTT1, GSTT2B, MIF",null,4282,653689,null,57.88,4.32,"rs2739330-T","rs2739330",0,2739330,null,1,0.42,2e-09,8.69897000433601,null,3.7,"[2.70-4.60] % increase","Affymetrix, Illumina, and Perlegen [~2.6 million] (imputed)","N"]
["V3 (down-regulated)","12/10/2011",21983787,"Barrett JH","10/09/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21983787","Genome-wide association study identifies three new melanoma susceptibility loci.","Melanoma","2,804 European ancestry cases, 7,618 European ancestry controls","5,551 European ancestry cases, 7,449 European ancestry controls","2q33.1",2,202162811,"CASP8","- ",null,null,130540,null,null,"rs13016963-A","rs13016963",0,13016963,"intron",0,0.37,9e-10,9.04575749056067,null,1.14,"[1.09-1.19] ","Illumina [594,997]","N"]
["V3 (down-regulated)","10/26/2011",21980299,"Bradfield JP","09/29/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21980299","A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.","Type 1 diabetes","9,934 European ancestry cases, 16,956 European ancestry controls","1,120 European ancestry affected trios","6q27",6,170379025,"WDR27, C6orf120, PHF10, TCTE3, C6orf208, LOC154449, DLL1, FAM120B, PSMB1, TBP, PCD2",null,80069,100270925,null,176.06,135.99,"rs924043-?","rs924043",0,924043,null,1,0.85,8e-09,8.09691001300805,null,1.35,"[NR] ","Affymetrix & Illumina [~2.54 million] (imputed)","N"]
["V3 (down-regulated)","10/19/2011",21926972,"Sklar P","09/18/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21926972","Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.","Bipolar disorder","7,481 European ancestry cases, 9,250 European ancestry controls","4,496 European ancestry cases, 42,422 European ancestry controls","3p21.1",3,52835354,"WDR82, TWF2, TNNC1, TMEM110, TLR9, STAB1,SPCS1, SNORD69, SNORD19, SNORD19B, SFMBT1, SEMA3G, RFT1, PRKCD, PPM1M, PHF7, PBRM1, NT5DC2, NISCH, NEK4, MUSTN1, LOC440957, ITIH1, ITIH3, ITIH4, GNL3, GLYCTK, GLT8D1, DNAH1, BAP1, ALAS1","- ",null,null,3699,null,null,"rs736408-C","rs736408",0,736408,"intron",0,"NR",2e-06,5.69897000433601,null,1.1,"[NR] ","Affymetrix & Illumina [2,415,422] (imputed)","N"]
["V3 (down-regulated)","10/19/2011",21926972,"Sklar P","09/18/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21926972","Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.","Bipolar disorder","7,481 European ancestry cases, 9,250 European ancestry controls","4,496 European ancestry cases, 42,422 European ancestry controls","2q11.2",2,97410949,"LMAN2L, FER1L5, CNNM4",null,81562,26504,null,5.14,15.69,"rs6746896-A","rs6746896",0,6746896,null,1,"NR",2e-06,5.69897000433601,null,1.1,"[NR] ","Affymetrix & Illumina [2,415,422] (imputed)","N"]
["V3 (down-regulated)","02/24/2012",21886157,"Suhre K","08/31/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21886157","Human metabolic individuality in biomedical and pharmaceutical research.","Metabolic traits","2,820 European ancestry individuals","NR","1p12",1,120257576,"PHGDH","- ",null,null,26227,null,null,"rs477992-A","rs477992",0,477992,"intron",0,0.313,3e-14,13.5228787452803,"(serine)",0.05,"[NR] unit decrease","Affmyetrix & Illumina [534,665] ","N"]
["V3 (down-regulated)","09/27/2011",21873549,"Strawbridge RJ","08/26/2011","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/21873549","Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.","Proinsulin levels","10,701 European ancestry nondiabetic adults","16,378 European ancestry nondiabetic adults","15q22.2",15,62383155,"VPS13C, C2CD4A, C2CD4B",null,145741,388125,null,20.04,72.58,"rs4502156-T","rs4502156",0,4502156,null,1,0.58,4e-20,19.397940008672,null,"NR","NR","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (down-regulated)","10/24/2012",21833088,"Sawcer S","08/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21833088","Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.","Multiple sclerosis","9,772 European ancestry cases, 16,849 European ancestry controls","4,218 European ancestry cases, 7,296 European ancestry controls","22q13.33",22,50971266,"ODF3B, SCO2","- ",null,null,440836,null,null,"rs140522-A","rs140522",0,140522,"nearGene-5",0,"NR",2e-08,7.69897000433601,null,1.1,"[1.09-1.12] ","Illumina [465,434]","N"]
["V3 (down-regulated)","10/24/2012",21833088,"Sawcer S","08/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21833088","Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.","Multiple sclerosis","9,772 European ancestry cases, 16,849 European ancestry controls","4,218 European ancestry cases, 7,296 European ancestry controls","1p22.1",1,93148377,"EVI5","- ",null,null,7813,null,null,"rs11810217-A","rs11810217",0,11810217,"intron",0,"NR",6e-15,14.2218487496163,null,1.15,"[1.13-1.16] ","Illumina [465,434]","N"]
["V3 (down-regulated)","08/18/2011",21785125,"Traglia M","07/25/2011","J Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/21785125","Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations.","Hepcidin levels","1,657 individuals","NR","3q22.1",3,133484029,"TF","- ",null,null,7018,null,null,"rs3811647-?","rs3811647",0,3811647,"intron",0,"NR",2e-16,15.698970004336,"(Tf)",0.34,"[0.26-0.42] ng/ml increase","Illumina [343,866]","N"]
["V3 (down-regulated)","08/12/2011",21779181,"Gorlova O","07/14/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21779181","Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.","Systemic sclerosis","2,296 European ancestry cases, 5,172 European ancestry controls","3,175 European ancestry cases, 4,210 European ancestry controls","6p21.32",6,32590925,"HLA-DQA1, HLA-DRB1",null,3123,3117,null,33.31,14.26,"rs3129763-?","rs3129763",0,3129763,null,1,0.25,1e-11,11,"(ATA positive)",1.65,"[1.42-1.91] ","Illumina [NR] (imputed)","N"]
["V3 (down-regulated)","08/22/2011",21743467,"Kote-Jarai Z","07/10/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21743467","Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.","Prostate cancer","6,621 European ancestry cases, 6,939 European ancestry controls","22,957 European ancestry cases, 23,234 European ancestry controls, 285 Japanese cases, 298 Japanese controls, 135 Chinese cases, 135 Chinese controls, 112 African American cases, 298 African American controls, 7,140 cases, 5,455 controls","2p11.2",2,85794297,"GGCX, VAMP8, VAMP5, RNF181",null,2677,8673,null,5.64,10.32,"rs10187424-A","rs10187424",0,10187424,null,1,0.59,3e-15,14.5228787452803,null,1.09,"[1.06-1.12] ","NR [2.6 million] (imputed)","N"]
["V3 (down-regulated)","07/20/2011",21738487,"Do CB","06/23/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21738487","Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.","Parkinson's disease","3,426 cases, 29,624 controls","NR","17p11.2",17,17715101,"SREBF1, RAI1","- ",null,null,"6720;10743",null,null,"rs11868035-G","rs11868035",0,11868035,"UTR-3;nearGene-3",0,0.69,6e-08,7.22184874961635,null,1.18,"[1.11-1.25] ","Illumina [522,782]","N"]
["V3 (down-regulated)","06/29/2011",21653640,"Eleftherohorinou H","06/13/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21653640","Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways.","Rheumatoid arthritis","2768 European ancestry cases, 4198 European ancestry controls","NR","6p21.32",6,32602269,"HLA-DQA1",null,3123,3117,null,44.66,2.91,"rs9272219-?","rs9272219",0,9272219,null,1,"NR",1e-45,44.9999999999999,null,1.92,"[1.75-2.08] ","Affymetrix & Illumina [NR]","N"]
["V3 (down-regulated)","07/07/2011",21665994,"Kutalik Z","06/10/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21665994","Genome-wide association study identifies two loci strongly affecting transferrin glycosylation.","Alcohol consumption","5,181 European ancestry individuals","2,284 European ancestry individauls","3q22.1",3,133494354,"TF","- ",null,null,7018,null,null,"rs1049296-T","rs1049296",0,1049296,"missense",0,0.17,5e-43,42.3010299956639,"(CDT percent)",0.29,"[0.25-0.33] unit decrease","Affymetrix [390,631] (imputed)","N"]
["V3 (down-regulated)","07/07/2011",21665994,"Kutalik Z","06/10/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21665994","Genome-wide association study identifies two loci strongly affecting transferrin glycosylation.","Alcohol consumption","5,181 European ancestry individuals","2,284 European ancestry individauls","3q22.1",3,133475812,"TF","- ",null,null,7018,null,null,"rs1799899-A","rs1799899",0,1799899,"missense",0,0.06,1e-09,8.99999999999999,"(CDT concentration)",0.4,"[0.27-0.53] unit decrease","Affymetrix [390,631] (imputed)","N"]
["V3 (down-regulated)","07/07/2011",21665994,"Kutalik Z","06/10/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21665994","Genome-wide association study identifies two loci strongly affecting transferrin glycosylation.","Alcohol consumption","5,181 European ancestry individuals","2,284 European ancestry individauls","3q22.1",3,133484029,"TF","- ",null,null,7018,null,null,"rs3811647-A","rs3811647",0,3811647,"intron",0,0.32,1e-35,35,"(Total transferrin)",0.36,"[0.30-0.42] unit increase","Affymetrix [390,631] (imputed)","N"]
["V3 (down-regulated)","06/08/2011",21623375,"Albagha OM","05/29/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21623375","Genome-wide association identifies three new susceptibility loci for Paget's disease of bone.","Paget's disease","741 European ancestry cases, 2,699 European ancestry controls","1,474 European descent cases, 1,671 European descent controls","15q24.1",15,74336633,"PML","- ",null,null,5371,null,null,"rs5742915-C","rs5742915",0,5742915,"missense",0,0.45,2e-14,13.698970004336,null,1.34,"[1.25-1.45] ","Illumina [2,487,078] (imputed)","N"]
["V3 (down-regulated)","05/27/2011",21546767,"Murea M","05/05/2011","Am J Nephrol","http://www.ncbi.nlm.nih.gov/pubmed/21546767","Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.","Dialysis-related mortality","610 African American type 2 diabetics","NR","2p13.1",2,74245777,"TET3, DGUOK",null,1716,200424,null,59.69,27.67,"rs6546886-?","rs6546886",0,6546886,null,1,0.29,3e-06,5.52287874528033,null,2.13,"[1.55-2.93] ","Affymetrix [832,357]","N"]
["V3 (down-regulated)","05/25/2011",21502966,"Weber F","04/19/2011","Pharmacogenomics J","http://www.ncbi.nlm.nih.gov/pubmed/21502966","Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-&#x003b2; therapy in multiple sclerosis patients.","Response to interferon beta therapy","178 European ancestry antibody-positive individuals, 178 European ancestry antibody-negative individuals","350 European ancestry antibody-positive individuals, 468 European ancestry antibody-negative individuals","6p21.32",6,32599999,"HLA-DQA1, HLA-DRB1",null,3123,3117,null,42.39,5.18,"rs9272105-A","rs9272105",0,9272105,null,1,0.44,4e-10,9.39794000867203,null,0.26,"[NR] unit increase","Illumina [~317,000]","N"]
["V3 (down-regulated)","04/24/2013",21483845,"McLaren CE","03/31/2011","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/21483845","Genome-wide association study identifies genetic loci associated with iron deficiency.","Iron status biomarkers","336 European ancestry iron deficiency cases, 343 European ancestry controls","71 European ancestry iron deficiency cases, 161 European ancestry controls","3q22.1",3,133484029,"TF","- ",null,null,7018,null,null,"rs3811647-A","rs3811647",0,3811647,"intron",0,"NR",8e-06,5.09691001300805,"(Unsaturated iron-binding capacity)",21.62,"[NR] ug/dL increase","Illumina [331,060]","N"]
["V3 (down-regulated)","04/24/2013",21483845,"McLaren CE","03/31/2011","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/21483845","Genome-wide association study identifies genetic loci associated with iron deficiency.","Iron status biomarkers","336 European ancestry iron deficiency cases, 343 European ancestry controls","71 European ancestry iron deficiency cases, 161 European ancestry controls","3q22.1",3,133484029,"TF","- ",null,null,7018,null,null,"rs3811647-A","rs3811647",0,3811647,"intron",0,"NR",5e-10,9.30102999566398,"(Total iron-binding capacity)",21.49,"[NR] ug/dL increase","Illumina [331,060]","N"]
["V3 (down-regulated)","04/12/2011",21399633,"Gharavi AG","03/13/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21399633","Genome-wide association study identifies susceptibility loci for IgA nephropathy.","Nephropathy","1,194 Chinese ancestry cases, 902 Chinese ancestry controls","712 Chinese ancestry cases, 748 Chinese ancestry controls, 1,238 European ancestry cases, 1,172 European ancestry controls","6p21.32",6,32681631,"HLA-DRB1, HLA-DQA1, HLA-DQB1",null,404026,3118,null,7.05,27.53,"rs9275596-?","rs9275596",0,9275596,null,1,"0.73 (EA)",2e-26,25.698970004336,null,1.59,"[NR] ","Illumina [498,322]","N"]
["V3 (down-regulated)","04/11/2011",21378990,"Schunkert H","03/06/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21378990","Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.","Coronary heart disease","22,233 European ancestry cases, 64,762 European ancestry controls","28,834 cases, 27,674 controls, 2,115 individuals.","17q21.32",17,46988597,"UBE2Z, GIP, ATP5G1, SNF8","- ",null,null,65264,null,null,"rs46522-T","rs46522",0,46522,"intron",0,0.53,2e-08,7.69897000433601,null,1.06,"[1.04-1.08] ","Affymetrix & Illumina {~2.3 million] (imputed)","N"]
["V3 (down-regulated)","04/07/2011",21408207,"Chung SA","03/03/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21408207","Differential genetic associations for systemic l (up-regulated)us erythematosus based on anti-dsDNA autoantibody production.","Systemic l (up-regulated)us erythematosus","811 anti-dsDNA positive European ancestry cases, 906 anti-dsDNA negative European ancestry cases, 4,813 European ancestry controls","NR","6p21.32",6,32664458,"HLA-DQA1, HLA-DQA2",null,3119,404026,null,29.99,9.46,"rs2647012-A","rs2647012",0,2647012,null,1,0.44,8e-06,5.09691001300805,"(case-only)",1.38,"[1.20-1.59] ","Illumina [421,318] (imputed)","N"]
["V3 (down-regulated)","04/05/2011",21323541,"Stanescu HC","02/22/2011","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/21323541","Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.","Nephropathy (idiopathic membranous)","556 European ancestry cases, 2,338 European ancestry controls","NR","6p21.32",6,32605884,"HLA-DQA1","- ",null,null,3117,null,null,"rs2187668-?","rs2187668",0,2187668,"intron",0,0.13,8e-93,92.096910013008,null,4.32,"[3.73-5.01] ","Illumina [242,824]","N"]
["V3 (down-regulated)","03/29/2011",21297633,"Anderson CA","02/06/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21297633","Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.","Ulcerative colitis","6,687 European ancestry cases, 19,718 European ancestry controls","9,628 European ancestry cases, 12,917 European ancestry controls","6p21.32",6,32429643,"HLA-DRB5, HLA-DQA1, HLA-DRB1, HLA-DRA, BTNL2",null,3132,3127,null,1.78,55.51,"rs9268853-T","rs9268853",0,9268853,null,1,0.66,1e-55,54.9999999999999,null,1.4,"[1.34-1.47] ","Affymetrix & Illumina [~1.1 million] (imputed)","N"]
["V3 (down-regulated)","03/29/2011",21297633,"Anderson CA","02/06/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21297633","Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.","Ulcerative colitis","6,687 European ancestry cases, 19,718 European ancestry controls","9,628 European ancestry cases, 12,917 European ancestry controls","5p15.33",5,594083,"EXOC3",null,100616381,55722,null,58.09,18.32,"rs11739663-T","rs11739663",0,11739663,null,1,0.77,3e-08,7.52287874528033,null,1.15,"[1.09-1.21] ","Affymetrix & Illumina [~1.1 million] (imputed)","N"]
["V3 (down-regulated)","02/03/2011",21208937,"Pichler I","01/04/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21208937","Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels.","Iron levels"," (up-regulated) to 5,633 Caucasian individuals"," (up-regulated) to 3,457 Caucasian individuals","3q22.1",3,133484029,"TF","- ",null,null,7018,null,null,"rs3811647-A","rs3811647",0,3811647,"intron",0,0.29,3e-47,46.5228787452803,"(transferrin)",15.34,"[13.26-17.42] mg/dl increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (down-regulated)","01/12/2011",21131588,"Slager SL","12/03/2010","Blood","http://www.ncbi.nlm.nih.gov/pubmed/21131588","Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL.","Chronic lymphocytic leukemia","407 Caucasian cases, 296 Caucasian controls","252 Caucasian cases, 965 Caucasian controls","6p21.32",6,32606756,"HLA-DQA1","- ",null,null,3117,null,null,"rs9272535-A","rs9272535",0,9272535,"intron",0,0.27,9e-08,7.04575749056067,null,1.61,"[1.35-1.92] ","Affymetrix [827,777]","N"]
["V3 (down-regulated)","10/19/2012",21102463,"Franke A","11/21/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21102463","Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.","Crohn's disease","6,333 European ancestry cases, 15,056 European ancestry controls","15,694 European ancestry cases, 14,026 European ancestry controls, 414 European ancestry parent-offspring trios","19p13.2",19,10469975,"TYK2,ICAM1,ICAM3","- ",null,null,7297,null,null,"rs12720356-G","rs12720356",0,12720356,"missense",0,0.084,1e-12,12,null,1.12,"[1.06-1.19] ","Affymetrix & Illumina [953,241] (imputed)","N"]
["V3 (down-regulated)","01/06/2011",21076409,"Sotoodehnia N","11/14/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21076409","Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.","Ventricular conduction","40,407 European ancestry individuals","7,170 European ancestry individuals","1p32.3",1,51546140,"C1orf185, RNF11, CDKN2C,FAF1",null,100616189,391039,null,20.56,77.18,"rs17391905-G","rs17391905",0,17391905,null,1,0.05,3e-10,9.52287874528033,null,1.35,"[0.90-1.80] ms decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (down-regulated)","12/08/2010",20972438,"Rothman N","10/24/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20972438","A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.","Bladder cancer","3,532 European descent cases, 5,120 European descent controls","8,382 cases, 48,275 controls","1p13.3",null,null,"GSTM1","- ",{"$nulls":5},"Deletion assay","NR",{"$nulls":4},0.51,5e-31,null,null,1.47,"[1.38-1.57] ","Illumina [591,637]","N"]
["V3 (down-regulated)","12/03/2010",20966902,"Croteau-Chonka DC","10/21/2010","Obesity (Silver Spring)","http://www.ncbi.nlm.nih.gov/pubmed/20966902","Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.","Height","1,792 Filipino women","NR","1q23.3",1,164739171,"PBX1","- ",null,null,"5087;100505795",null,null,"rs6670655-T","rs6670655",0,6670655,"intron;ncRNA",0,0.18,3e-06,5.52287874528033,null,1.26,"[0.74-1.78] cm increase","Affymetrix [2,073,674](imputed)","N"]
["V3 (down-regulated)","11/02/2012",20889312,"Wang KS","10/01/2010","Schizophr Res","http://www.ncbi.nlm.nih.gov/pubmed/20889312","A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.","Bipolar disorder and schizophrenia","651 European American bipolar cases, 1,171 European American schizophrenia cases, 2,412 European American controls","NR","9q33.1",9,121359286,"ASTN2",null,7099,1620,null,879.52,569.62,"rs11789399-?","rs11789399",0,11789399,null,1,"NR",6e-09,8.22184874961635,null,1.29,"[NR] ","Affymetrix [722,112]","N"]
["V3 (down-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","15q24.1",15,74241506,"PML","- ",null,null,4016,null,null,"rs750460-?","rs750460",0,750460,"intron",0,"NR",4e-12,11.397940008672,"(Conditioned on rs5742915)","NR","NR","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V3 (down-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","15q24.1",15,74336633,"PML","- ",null,null,5371,null,null,"rs5742915-T","rs5742915",0,5742915,"missense",0,0.54,1e-15,15,null,0.03,"[NR] unit decrease","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V3 (down-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","11q13.2",11,66826160,"RHOD","- ",null,null,29984,null,null,"rs7112925-T","rs7112925",0,7112925,"intron",0,0.35,9e-10,9.04575749056067,null,0.02,"[NR] unit decrease","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V3 (down-regulated)","09/24/2010",20708005,"Chalasani N","08/10/2010","Gastroenterology","http://www.ncbi.nlm.nih.gov/pubmed/20708005","Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.","Non-alcoholic fatty liver disease histology (lobular)","236 non-Hispanic Caucasian women","NR","8p23.1",8,11684463,"FDFT1","- ",null,null,2222,null,null,"rs2645424-A","rs2645424",0,2645424,"intron",0,0.4,3e-06,5.52287874528033,null,0.3,"[NR] unit decrease","Illumina [324,623]","N"]
["V3 (down-regulated)","09/24/2010",20708005,"Chalasani N","08/10/2010","Gastroenterology","http://www.ncbi.nlm.nih.gov/pubmed/20708005","Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.","Non-alcoholic fatty liver disease histology (other)","236 non-Hispanic Caucasian women","NR","8p23.1",8,11684463,"FDFT1","- ",null,null,2222,null,null,"rs2645424-A","rs2645424",0,2645424,"intron",0,0.4,7e-07,6.15490195998574,"(NAS)",0.77,"[NR] unit decrease","Illumina [324,623]","N"]
["V3 (down-regulated)","09/15/2010",20700443,"Meyer TE","08/05/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20700443","Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels.","Magnesium levels","15,366 European descent individuals","8,463 European descent individuals","16q22.1",16,68383047,"PRMT7","- ",null,null,54496,null,null,"rs7197653-C","rs7197653",0,7197653,"intron",0,0.15,2e-06,5.69897000433601,null,0.01,"[0.003-0.007] mmol/L decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (down-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","Cholesterol, total"," (up-regulated) to 100,184 European descent individuals",null,"1p22.1",1,93009438,"GVI1,EVI5","- ",null,null,7813,null,null,"rs7515577-C","rs7515577",0,7515577,"intron",0,0.21,3e-08,7.52287874528033,null,1.18,"[0.71-1.65] mg/dL decrease","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V3 (down-regulated)","06/02/2010",20453838,"Turnbull C","05/09/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20453838","Genome-wide association study identifies five new breast cancer susceptibility loci.","Breast cancer","3,659 UK cases, 4,897 UK controls","12,576 European cases, 12,223 European controls","11q13.3",11,69328764,"MYEOV,CCND1,ORAOV1,FGF19,FGF4,FGF3",null,390218,595,null,257.49,127.11,"rs614367-T","rs614367",0,614367,null,1,0.15,3e-15,14.5228787452803,null,1.15,"[1.10-1.20] ","Illumina [582,886]","N"]
["V3 (down-regulated)","05/18/2010",20410501,"Jin Y","04/21/2010","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/20410501","Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.","Vitiligo","1,392 European ancestry cases, 2,629 European ancestry controls","647 European ancestry cases, 1,056 European ancestry controls, 183 European ancestry trios, 332 European ancestry multiplex families","6p21.32",6,32373698,"BTNL2,HLA-DRA,HLA-DQA1","- ",null,null,56244,null,null,"rs3806156-T","rs3806156",0,3806156,"intron",0,0.37,7e-19,18.1549019599857,null,1.42,"[1.32-1.54] ","Illumina [520,460]","N"]
["V3 (down-regulated)","03/30/2010",20212171,"Buil A","03/08/2010","Blood","http://www.ncbi.nlm.nih.gov/pubmed/20212171","C4BPB/C4BPA is a new susceptibility locus for venous thrombosis with unknown protein S-independent mechanism: results from genome-wide association and gene expression analyses followed by case-control studies.","C4b binding protein levels","352 related Spanish individuals","NR","1q32.2",1,207269858,"C4BPB, C4BPA","- ",null,null,725,null,null,"rs3813948-C","rs3813948",0,3813948,"intron",0,"NR",4e-10,9.39794000867203,"(%a7b0)","NR","NR","Illumina [283,437]","N"]
["V3 (down-regulated)","04/06/2010",20195266,"Adkins DE","03/02/2010","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/20195266","Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.","Response to antipsychotic treatment","738 European American, African American, and other schizophrenia cases","NR","9q33.1",9,119926426,"ASTN2","- ",null,null,23245,null,null,"rs4838255-?","rs4838255",0,4838255,"intron",0,0.139,3e-07,6.52287874528033,"(perphenazine-triglycerides)","NR","NR","Affymetrix [492,900]","N"]
["V3 (down-regulated)","03/29/2010",20190752,"Dubois PC","02/28/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20190752","Multiple common variants for celiac disease influencing immune gene expression.","Celiac disease","4,533 European descent cases, 10,750 European descent controls","4,918 European descent cases, 5,684 European descent controls","6p21.32",6,32605884,"HLA-DQA1, HLA-DQB1","- ",null,null,3117,null,null,"rs2187668-A","rs2187668",0,2187668,"intron",0,0.26,1e-50,50,null,6.23,"[5.95-6.52] ","Illumina [292,387]","N"]
["V3 (down-regulated)","03/29/2010",20190752,"Dubois PC","02/28/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20190752","Multiple common variants for celiac disease influencing immune gene expression.","Celiac disease","4,533 European descent cases, 10,750 European descent controls","4,918 European descent cases, 5,684 European descent controls","3q13.33",3,119118796,"CD80, KTELC1","- ",null,null,57514,null,null,"rs11712165-C","rs11712165",0,11712165,"intron",0,0.39,8e-09,8.09691001300805,null,1.13,"[1.08-1.17] ","Illumina [292,387]","N"]
["V3 (down-regulated)","02/08/2010",20081857,"Saxena R","01/17/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20081857?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=3","Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.","Two-hour glucose challenge","15,234 European individuals"," (up-regulated) to 30,620 European individuals","15q22.2",15,62332980,"VPS13C","- ",null,null,54832,null,null,"rs17271305-G","rs17271305",0,17271305,"intron",0,"NR",1e-07,7,null,0.06,"[0.04-0.08 mmol/L increase","Affymetrix & Illumina [NR]","N"]
["V3 (down-regulated)","11/09/2009",19836008,"Landi MT","10/15/2009","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/19836008?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=5","A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.","Lung adenocarcinoma","5,739 European descent cases, 5,848 European descent controls","7,561 European descent cases, 13,818 European descent controls","6p21.33",6,31620520,"BAT3, APOM","- ",null,null,"7917;55937",null,null,"rs3117582-C","rs3117582",0,3117582,"nearGene-5;intron",0,0.1,5e-12,11.3010299956639,null,1.22,"[1.15-1.29] ","Illumina [515,922]","N"]
["V3 (down-regulated)","10/05/2009",19772629,"Latourelle JC","09/22/2009","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/19772629?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genomewide association study for onset age in Parkinson disease.","Parkinson's disease (age of onset)","857 white familial cases, 440 white idiopathic cases","747 Italian idiopathic cases","2p13.3",2,69723710,"AAK1","- ",null,null,22848,null,null,"rs7577851-T","rs7577851",0,7577851,"intron",0,"NR",9e-06,5.04575749056067,null,6.85,"[NR] years younger","Illumina and Perlegen [1,861,750] (imputed)","N"]
["V3 (down-regulated)","11/08/2012",19734545,"Need AC","09/04/2009","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19734545?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.","Cognitive performance"," (up-regulated) to 1,295 individuals","NR","13q14.11",13,43727849,"DNAJC15",null,29103,100420520,null,44.54,25.79,"rs1324015-?","rs1324015",0,1324015,null,1,0.4193,9e-06,5.04575749056067,"(PC1)","NR","NR","Illumina [475,971]","N"]
["V3 (down-regulated)","11/08/2012",19734545,"Need AC","09/04/2009","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19734545?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.","Cognitive performance"," (up-regulated) to 1,295 individuals","NR","14q23.3",14,64899055,"MTHFD1","- ",null,null,4522,null,null,"rs10498514-?","rs10498514",0,10498514,"intron",0,0.01817,8e-07,6.09691001300805,"(SWM strategy)","NR","NR","Illumina [475,971]","N"]
["V3 (down-regulated)","09/14/2009",19654303,"Broderick P","08/04/2009","Cancer Res","http://www.ncbi.nlm.nih.gov/pubmed/19654303","Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.","Lung cancer","1,952 European ancestry cases, 1,438 European ancestry controls","5,608 European ancestry cases, 6,767 European ancestry controls","6p21.33",6,31620520,"BAT3","- ",null,null,"7917;55937",null,null,"rs3117582-?","rs3117582",0,3117582,"nearGene-5;intron",0,"NR",4e-10,9.39794000867203,null,1.24,"[1.16-1.33] ","Illumina [511,919]","N"]
["V3 (down-regulated)","08/07/2009",19584346,"Vasan RS","07/08/2009","JAMA","http://www.ncbi.nlm.nih.gov/pubmed/19584346?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.","Aortic root size","12,612 European ancestry individuals","4,094 European ancestry individuals","5q23.2",5,122531347,"CCDC100, PPIC",null,93166,474341,null,7.6,40.32,"rs17470137-A","rs17470137",0,17470137,null,1,0.29,1e-11,11,null,0.03,"[0.02-0.04] cm increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V3 (down-regulated)","07/10/2009",19571809,"Shi J","07/01/2009","Nature","http://www.ncbi.nlm.nih.gov/pubmed/19571809","Common variants on chromosome 6p22.1 are associated with schizophrenia.","Schizophrenia","2,681 European ancestry cases, 2,653 European ancestry controls, 1,286 African American cases, 973 African American controls","5,327 European ancestry cases, 16,424 European ancestry controls","6p21.32",6,32602269,"HLA-DQA1",null,3123,3117,null,44.66,2.91,"rs9272219-G","rs9272219",0,9272219,null,1,0.72,7e-08,7.15490195998574,"(EA)",1.14,"[NR] ","Affymetrix [ (up-regulated) to 843,798]","N"]
["V3 (down-regulated)","06/30/2009",19525955,"Bahlo","06/14/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19525955?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.","Multiple sclerosis","1,618 European ancestry cases, 3,413 European ancestry controls","2,256 European ancestry cases, 2,310 European ancestry controls","1p22.1",1,93303603,"EVI5, RPL5","- ",null,null,"6125;388650",null,null,"rs6604026-G","rs6604026",0,6604026,"intron;intron",0,0.28,3e-06,5.52287874528033,null,1.17,"[NR] ","Illumina [302,098]","N"]
["V3 (down-regulated)","03/31/2009",19305408,"Newton-Cheh C","03/22/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19305408?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Common variants at ten loci influence QT interval duration in the QTGEN Study.","QT interval","13,685 individuals","15,854 individuals","16p13.13",16,11691753,"LITAF,CLEC16A, SNN, ZC3H7A, TNFRSF17",null,9516,8303,null,10.43,70.54,"rs8049607-T","rs8049607",0,8049607,null,1,0.49,5e-15,14.3010299956639,null,1.23,"[0.88-1.57] msec increase","Affymetrix and Illumina [ (up-regulated) to 2,543,686] (imputed)","N"]
["V3 (down-regulated)","04/02/2009",19305409,"Pfeufer A","03/22/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19305409?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Common variants at ten loci modulate the QT interval duration in the QTSCD Study.","QT interval","15,842 individuals"," (up-regulated) to 13,602 individuals","16p13.13",16,11691753,"LITAF",null,9516,8303,null,10.43,70.54,"rs8049607-T","rs8049607",0,8049607,null,1,0.46,6e-15,14.2218487496163,null,1.25,"[0.81-1.69] ms increase","Affymetrix and Illumina [unsure] (imputed)","N"]
["V3 (down-regulated)","01/21/2009",19122664,"Silverberg MS","01/04/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19122664?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.","Ulcerative colitis","1,022 cases, 2,503 controls","1,387 cases, 1,115 controls","6p21.32",6,32433167,"BTNL2, HLA-DRA, HLA-DRB5, HLA-DRB1, HLA-DQA1, HLA-DQB1",null,3132,3127,null,5.3,51.98,"rs2395185-?","rs2395185",0,2395185,null,1,0.67,1e-16,16,null,1.52,null,"Illumina [280,748]","N"]
["V3 (down-regulated)","01/14/2009",19084217,"Benyamin B","12/17/2008","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/19084217?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.","Iron status biomarkers","459 twin pairs","NR","3q22.1",3,133410661,"TF","- ",null,null,100129696,null,null,"rs1867504-?","rs1867504",0,1867504,null,0,"NR",2e-06,5.69897000433601,"(serum transferrin)","NR","NR","Illumina [315,887]","N"]
["V3 (down-regulated)","01/14/2009",19084217,"Benyamin B","12/17/2008","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/19084217?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.","Iron status biomarkers","459 twin pairs","NR","3q22.1",3,133475722,"TF","- ",null,null,7018,null,null,"rs1799852-?","rs1799852",0,1799852,"cds-synon",0,0.09,5e-06,5.30102999566398,"(serum transferrin)",0.43,"[0.25-0.61] s.d. decrease","Illumina [315,887]","N"]
["V3 (down-regulated)","01/14/2009",19084217,"Benyamin B","12/17/2008","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/19084217?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.","Iron status biomarkers","459 twin pairs","NR","3q22.1",3,133484029,"TF","- ",null,null,7018,null,null,"rs3811647-?","rs3811647",0,3811647,"intron",0,"NR",3e-15,14.5228787452803,"(serum transferrin)",0.46,"[0.34-0.58] s.d. decrease","Illumina [315,887]","N"]
["V3 (down-regulated)","01/14/2009",19084217,"Benyamin B","12/17/2008","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/19084217?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.","Iron status biomarkers","411 family members","NR","3q22.1",3,133508464,"TF","- ",null,null,58477,null,null,"rs1830084-A","rs1830084",0,1830084,"intron",0,0.36,1e-09,8.99999999999999,"(serum transferrin)",0.43,"[NR] s.d. increase","Affymetrix [100,846]","N"]
["V3 (down-regulated)","11/25/2008",18978787,"Wang Y","11/02/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18978787?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Common 5p15.33 and 6p21.33 variants influence lung cancer risk.","Lung cancer","1,952 cases,1,438 controls","7,579 cases,8,236 controls","6p21.33",6,31620520,"BAT3,MSH5","- ",null,null,"7917;55937",null,null,"rs3117582-C","rs3117582",0,3117582,"nearGene-5;intron",0,"NR",5e-10,9.30102999566398,null,1.24,"[1.16-1.33] ","Illumina[223,891]","N"]
["V3 (down-regulated)","12/09/2008",18951430,"Anney RJ","10/24/2008","Am J Med Genet B Neuropsychiatr Genet","http://www.ncbi.nlm.nih.gov/pubmed/18951430?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.","Attention deficit hyperactivity disorder and conduct disorder","938 affected trios","NR","10p15.2",10,3284007,"PITRM1",null,10531,1316,null,68.97,534.18,"rs2764980-A","rs2764980",0,2764980,null,1,0.51,9e-06,5.04575749056067,null,"NR","NR","Perlegen[378,332]","N"]
["V3 (down-regulated)","05/07/2009",18839057,"Lesch KP","10/07/2008","J Neural Transm","http://www.ncbi.nlm.nih.gov/pubmed/18839057?ordinalpos=16&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.","Attention deficit hyperactivity disorder","343 cases, 304 controls","NR","9q33.1",9,119333683,"ASTN2","- ",null,null,23245,null,null,"rs10983238-?","rs10983238",0,10983238,"intron",0,"NR",1e-07,7,null,"NR","NR","Affymetrix [504,219](pooled)","N"]
["V3 (down-regulated)","11/25/2008",18758464,"Kugathasan S","08/31/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18758464?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.","Inflammatory bowel disease","1,011 cases,4,250 controls","1,922 cases,14,124 controls","6p21.32",6,32569691,"HLA-DQA1",null,3123,3117,null,12.08,35.49,"rs477515-?","rs477515",0,477515,null,1,0.69,1e-08,8,null,1.38,"[1.23-1.54] ","Illumina[NR]","N"]
["V3 (down-regulated)","11/25/2008",18668548,"Julia A","08/01/2008","Arthritis Rheum","http://www.ncbi.nlm.nih.gov/pubmed/18668548?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility.","Rheumatoid arthritis","400 cases,400 controls","410 cases,394 controls","6p21.32",6,32663851,"HLA-DQA1, HLA-DQA2",null,3119,404026,null,29.39,10.07,"rs6457617-?","rs6457617",0,6457617,null,1,"NR",1e-09,8.99999999999999,null,"NR","NR","Illumina[299,918]","N"]
["V3 (down-regulated)","11/25/2008",18391951,"Gudbjartsson DF","04/06/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18391951?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Many sequence variants affecting diversity of adult human height.","Height","30,968 individuals","8,541 individuals","6p22.3",6,17699322,"N (up-regulated)153, CAP2, KIF13A","- ",null,null,9972,null,null,"rs12199222-T","rs12199222",0,12199222,"intron",0,0.33,7e-07,6.15490195998574,null,4.4,"[2.64-6.16] % s.d. taller","Illumina and Affymetrix[ (up-regulated) to 304,226]","N"]
["V3 (down-regulated)","11/25/2008",18391952,"Weedon MN","04/06/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18391952?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genome-wide association analysis identifies 20 loci that influence adult height.","Height","13,665 individuals","16,482 individuals","3q22.2",3,134233092,"ANAPC13,CEP63","- ",null,null,80254,null,null,"rs10935120-A","rs10935120",0,10935120,"intron",0,0.33,7e-08,7.15490195998574,null,0.06,"[0.03-0.09] s.d. shorter - among males","Affymetrix[402,951]","N"]
["V3 (down-regulated)","11/25/2008",18204098,"Hom G","01/20/2008","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/18204098?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Association of systemic l (up-regulated)us erythematosus with C8orf13-BLK and ITGAM-ITGAX.","Systemic l (up-regulated)us erythematosus","1,311 cases,3,340 controls","793 cases,857 controls","6p21.32",6,32605884,"HLA-DQA1","- ",null,null,3117,null,null,"rs2187668-A","rs2187668",0,2187668,"intron",0,0.11,3e-21,20.5228787452803,null,"NR","NR","Illumina[502,033]","N"]
["V3 (down-regulated)","11/25/2008",17558408,"van Heel DA","06/10/2007","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/17558408?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.","Celiac disease","778 cases,1,422 controls","991 cases,1,489 controls","6p21.32",6,32605884,"HLA-DQA1","- ",null,null,3117,null,null,"rs2187668-A","rs2187668",0,2187668,"intron",0,0.14,1e-19,19,null,7.04,"[6.08-8.15] ","Illumina[310,605]","N"]
["V4 (up-regulated)","06/26/2013",23508266,"Duan QL","03/19/2013","Pharmacogenomics J","http://www.ncbi.nlm.nih.gov/pubmed/23508266","A genome-wide association study of bronchodilator response in asthmatics.","Asthma (bronchodilator response)"," (up-regulated) to 403 European ancestry asthmatic children and their parents","764 European ancestry cases, 592 Costa Rican ancestry cases","10p15.1",10,4240870,"PRKCQ,IL15RA,IL2RA,KLF6",null,1316,338588,null,413.4,457.48,"rs11252394-A","rs11252394",0,11252394,null,1,0.08,2e-07,6.69897000433601,"(Additive Model)","NR","NR","Illumina [534,290]","N"]
["V4 (up-regulated)","06/01/2013",23456168,"Hao Y","03/03/2013","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23456168","Genome-wide association study in Han Chinese identifies three novel loci for human height.","Height","6,534 Han Chinese ancestry individuals","1,881 Han Chinese ancestry individuals from 637 families","10q21.1",10,60210790,"TFAM",null,7019,80114,null,51.8,62.11,"rs10509091-T","rs10509091",0,10509091,null,1,0.35,6e-06,5.22184874961635,null,0.07,"[0.043-0.105] unit increase","Affymetrix [1,532,051] (Imputed)","N"]
["V4 (up-regulated)","06/06/2013",23453885,"Smoller JW","02/27/2013","Lancet","http://www.ncbi.nlm.nih.gov/pubmed/23453885","Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.","Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined)","6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls","NR","1p31.1",1,79238015,"IFI44L, IFI44",null,100130630,64123,null,105.63,117.43,"rs4650608-T","rs4650608",0,4650608,null,1,"NR",1e-06,5.99999999999999,"(5 degree of freedom test)",1.06,"[1.03-1.09] ","NR [1,252,901] (imputed)","N"]
["V4 (up-regulated)","06/06/2013",23417110,"Tin A","02/16/2013","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23417110","Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin.","Beta-2 microglubulin plasma levels","6,728 European ancestry individuals",null,"NR",null,null,"HLA-C","- ",{"$nulls":5},"HLA-C*07:01","HLA-C*07:01",{"$nulls":4},0.16,1e-18,null,null,0.05,"[0.042-0.066] unit increase","Affymetrix [2.5 million] (Imputed)","N"]
["V4 (up-regulated)","06/06/2013",23417110,"Tin A","02/16/2013","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23417110","Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin.","Beta-2 microglubulin plasma levels","6,728 European ancestry individuals",null,"NR",null,null,"HLA-B","- ",{"$nulls":5},"HLA-B*08:01","HLA-B*08:01",{"$nulls":4},0.13,2e-20,null,null,0.06,"[0.046-0.074] unit increase","Affymetrix [2.5 million] (Imputed)","N"]
["V4 (up-regulated)","06/06/2013",23417110,"Tin A","02/16/2013","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23417110","Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin.","Beta-2 microglubulin plasma levels","6,728 European ancestry individuals",null,"NR",null,null,"HLA-B","- ",{"$nulls":5},"HLA-B*15:01","HLA-B*15:01",{"$nulls":4},0.07,2e-10,null,null,0.05,"[0.034-0.066] unit decrease","Affymetrix [2.5 million] (Imputed)","N"]
["V4 (up-regulated)","06/06/2013",23417110,"Tin A","02/16/2013","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23417110","Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin.","Beta-2 microglubulin plasma levels","6,728 European ancestry individuals",null,"NR",null,null,"HLA-B","- ",{"$nulls":5},"HLA-B*57:01","HLA-B*57:01",{"$nulls":4},0.04,4e-07,null,null,0.06,"[0.038-0.082] unit decrease","Affymetrix [2.5 million] (Imputed)","N"]
["V4 (up-regulated)","06/06/2013",23417110,"Tin A","02/16/2013","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23417110","Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin.","Beta-2 microglubulin plasma levels","6,728 European ancestry individuals",null,"NR",null,null,"HLA-C","- ",{"$nulls":5},"HLA-C*03:04","HLA-C*03:04",{"$nulls":4},0.08,8e-08,null,null,0.04,"[0.027-0.059] unit decrease","Affymetrix [2.5 million] (Imputed)","N"]
["V4 (up-regulated)","06/06/2013",23417110,"Tin A","02/16/2013","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23417110","Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin.","Beta-2 microglubulin plasma levels","6,728 European ancestry individuals",null,"6p21.33",6,31238318,"HLA-C","- ",null,null,3107,null,null,"rs9264638-A","rs9264638",0,9264638,"intron",0,0.58,2e-23,22.698970004336,null,0.04,"[0.032-0.048] unit decrease","Affymetrix [2.5 million] (Imputed)","N"]
["V4 (up-regulated)","06/06/2013",23417110,"Tin A","02/16/2013","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23417110","Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin.","Beta-2 microglubulin plasma levels","6,728 European ancestry individuals",null,"6p21.33",6,31322559,"HLA-B","- ",null,null,3106,null,null,"rs2523608-A","rs2523608",0,2523608,"intron",0,0.59,9e-09,8.04575749056067,null,0.02,"[0.012-0.028] unit increase","Affymetrix [2.5 million] (Imputed)","N"]
["V4 (up-regulated)","06/06/2013",23417110,"Tin A","02/16/2013","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23417110","Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin.","Beta-2 microglubulin plasma levels","6,728 European ancestry individuals",null,"6p21.33",6,31362310,"HLA-B",null,267015,100507436,null,12.05,5.25,"rs16899524-C","rs16899524",0,16899524,null,1,0.93,1e-08,8,null,0.04,"[0.026-0.054] unit increase","Affymetrix [2.5 million] (Imputed)","N"]
["V4 (up-regulated)","06/06/2013",23417110,"Tin A","02/16/2013","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23417110","Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin.","Beta-2 microglubulin plasma levels","6,728 European ancestry individuals",null,"NR",null,null,"HLA-C","- ",{"$nulls":5},"HLA-C*03:03","HLA-C*03:03",{"$nulls":4},0.05,1e-06,null,null,0.05,"[0.030-0.070] unit decrease","Affymetrix [2.5 million] (Imputed)","N"]
["V4 (up-regulated)","05/09/2013",23377640,"GENDEP Investigators","02/01/2013","Am J Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23377640 ","Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.","Major depressive disorder"," (up-regulated) to 2,256 European ancestry cases","NR","6p22.3",6,16256043,"MYLIP,GMPR,ATXN1","- ",null,null,2766,null,null,"rs10484358-T","rs10484358",0,10484358,"intron",0,0.0827112,1e-06,5.99999999999999,"(% improvement - SSRI treated - 2 weeks)",0.43,"[0.25-0.6] unit decrease","Illumina & Affymetrix [1.2 million] (Imputed)","N"]
["V4 (up-regulated)","05/01/2013",23326239,"Rubicz R","01/10/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23326239","A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1).","Epstein-Barr virus immune response (EBNA-1)","1,367 Mexican American indivduals","589 Mexican American indivduals","6p21.32",6,32628428,"HLA-DQB1, C6orf15, PSORS1C1, HLA-B, BAT2, BAT4, EHMT2, PRRT1, NOTCH4, ","- ",null,null,3119,null,null,"rs2854275-T","rs2854275",0,2854275,"intron",0,0.064,2e-10,9.69897000433601,"(Conditional on rs477515 - Quantitative)",0.45,"[NR] unit decrease","Illumina [944,565]","N"]
["V4 (up-regulated)","03/28/2013",23291589,"Lu Y","01/06/2013","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23291589 ","Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.","Corneal structure","13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals","NR","11q23.1",11,110913240,"ARHGAP20, POU2AF1",null,57569,100271363,null,329.33,63.05,"rs4938174-A","rs4938174",0,4938174,null,1,0.31,4e-09,8.39794000867203,null,0.06,"[0.04-0.08] unit increase","Illumina & Affymetrix [~1 Million] (Imputed)","N"]
["V4 (up-regulated)","03/05/2013",23263487,"Jia WH","12/23/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263487","Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer.","Colorectal cancer","2,098 East Asian ancestry cases, 5,749 East Asian ancestry controls","5,358 East Asian ancestry cases, 5,922 East Asian ancestry controls, 26,060 European ancestry individuals","12p13.32",12,4368352,"CCND2, PARP11, FGF23, FGF6, C12orf5, RAD51AP1",null,100129645,894,null,139.23,14.55,"rs10774214-T","rs10774214",0,10774214,null,1,0.379,3e-08,7.52287874528033,null,1.09,"[1.06-1.13] ","Illumina & Affymetrix (1,636,380) imputed","N"]
["V4 (up-regulated)","03/05/2013",23263487,"Jia WH","12/23/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263487","Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer.","Colorectal cancer","2,098 East Asian ancestry cases, 5,749 East Asian ancestry controls","5,358 East Asian ancestry cases, 5,922 East Asian ancestry controls, 26,060 European ancestry individuals","12p13.32",12,4368352,"CCND2, PARP11, FGF23, FGF6, C12orf5, RAD51AP1",null,100129645,894,null,139.23,14.55,"rs10774214-T","rs10774214",0,10774214,null,1,0.352,5e-10,9.30102999566398,"(East Asian)",1.17,"[1.11-1.23] ","Illumina & Affymetrix (1,636,380) imputed","N"]
["V4 (up-regulated)","03/15/2013",23263486,"Kottgen A","12/23/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263486","Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.","Urate levels","49,825 European ancestry men, 60,522 European ancestry women"," (up-regulated) to 32,813 European ancestry individuals","11q13.1",11,65560620,"OVOL1, LTBP3","- ",null,null,5017,null,null,"rs642803-T","rs642803",0,642803,"intron",0,0.46,3e-13,12.5228787452803,null,0.04,"[0.026-0.045] mg/dl decrease","Affymetrix, Illumina, Perlegen [2,450,547] (imputed)","N"]
["V4 (up-regulated)","02/27/2013",23266558,"Yamazaki K","12/21/2012","Gastroenterology","http://www.ncbi.nlm.nih.gov/pubmed/23266558","A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.","Crohn's disease","372 Japanese ancestry cases and 3,389 Japanese ancestry controls"," (up-regulated) to 1,151 Japanese ancestry cases and  (up-regulated) to 15,800 Japanese ancestry controls","6p21.32",6,32680928,"HLA-DQA2, HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DOB, PSMB9",null,404026,3118,null,6.35,28.24,"rs7765379-G","rs7765379",0,7765379,null,1,"NR",9e-59,58.0457574905606,null,1.93,"[1.78-2.09] ","Illumina [4,929,034] (imputed)","N"]
["V4 (up-regulated)","02/27/2013",23266558,"Yamazaki K","12/21/2012","Gastroenterology","http://www.ncbi.nlm.nih.gov/pubmed/23266558","A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.","Crohn's disease","372 Japanese ancestry cases and 3,389 Japanese ancestry controls"," (up-regulated) to 1,151 Japanese ancestry cases and  (up-regulated) to 15,800 Japanese ancestry controls","9p24.1",9,4985879,"JAK2","- ",null,null,3717,null,null,"rs2274471-A","rs2274471",0,2274471,"intron",0,"NR",5e-06,5.30102999566398,null,1.27,"[1.15-1.41] ","Illumina [4,929,034] (imputed)","N"]
["V4 (up-regulated)","02/27/2013",23284291,"Hancock DB","12/20/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23284291 ","Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.","Pulmonary function (interaction)","50,047 European ancestry individuals","NR","1p36.13",1,17306675,"MFAP2","- ",null,null,4237,null,null,"rs2284746-?","rs2284746",0,2284746,"intron",0,"NR",2e-11,10.698970004336,"(FEV1/FVC, Pack-years)","NR","NR","NR [~2.5 Million] (imputed)","N"]
["V4 (up-regulated)","03/15/2013",23263863,"Li J","12/20/2012","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263863","GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.","Platelet counts","7,943 African American children, 6,234 European ancestry children","NR","6p21.31",6,33540209,"BAK1","- ",null,null,578,null,null,"rs210134-A","rs210134",0,210134,"nearGene-3",0,0.2675,2e-08,7.69897000433601,"(AA)",8.92,"[5.82-12.02] unit decrease","Illumina [544,917]","N"]
["V4 (up-regulated)","03/15/2013",23263863,"Li J","12/20/2012","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263863","GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.","Platelet counts","7,943 African American children, 6,234 European ancestry children","NR","6p21.31",6,33541719,"BAK1 ","- ",null,null,578,null,null,"rs513349-A ","rs513349",0,513349,"intron",0,"NR",2e-12,11.698970004336,null,7.75,"[5.59-9.92] unit decrease","Illumina [544,917]","N"]
["V4 (up-regulated)","12/16/2012",23001997,"Hou S","12/06/2012","Arthritis Rheum","http://www.ncbi.nlm.nih.gov/pubmed/23001997","Identification of a susceptibility locus in STAT4 for Beh&#x000e7;et's disease in Han Chinese in a genome-wide association study.","Behcet's disease","147 Han Chinese cases, 951 Han Chinese controls","554 Han Chinese cases, 1,159 Han Chinese controls","6p21.33",6,31336418,"MICA, MICB, DHFRP2",null,729816,100462812,null,1.68,9.08,"rs9266406-?","rs9266406",0,9266406,null,1,0.4,2e-10,9.69897000433601,null,2.29,"[1.77-2.95] ","Affyemtrix [661,736]","N"]
["V4 (up-regulated)","03/19/2013",23222517,"van der Harst P","12/05/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23222517","Seventy-five genetic loci influencing the human red blood cell.","Red blood cell traits","62,553 European ancestry individuals, 9,308 South Asian ancestry individuals","63,506 European ancestry individuals","22q13.33",22,50971266,"ODF3B, TYMP, NCAPH2, SCO2","- ",null,null,440836,null,null,"rs140522-C","rs140522",0,140522,"nearGene-5",0,0.67,5e-23,22.3010299956639,"(EA, MCV)",0.29,"[0.23-0.35] unit increase","Illumina, Affymetrix & Perlegen [2,711,806] imputed","N"]
["V4 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","1q23.1",1,159002222,"IFI16, MNDA, AIM2","- ",null,null,3428,null,null,"rs861318-A","rs861318",0,861318,"intron",0,0.12,1e-06,5.99999999999999,"(Diet carbohydrate )",0.04,"[NR]  g/d increase","Illumina [899,892]","N"]
["V4 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","3p21.31",3,48507575,"TREX1","- ",null,null,11277,null,null,"rs3135940-A","rs3135940",0,3135940,"intron",0,0.045,6e-06,5.22184874961635,"(IGFBP-3 )",0.03,"[NR]  ng/mL increase","Illumina [899,892]","N"]
["V4 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","11p15.1",11,20356444,"HTATIP2",null,120237,10553,null,174.57,28.79,"rs7128099-G","rs7128099",0,7128099,null,1,0.335,3e-06,5.52287874528033,"(Adiponectin )",0.03,"[NR]  ng/mL increase","Illumina [899,892]","N"]
["V4 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","15q26.1",15,89249139,"ISG20",null,3669,176,null,50.26,97.54,"rs8027587-G","rs8027587",0,8027587,null,1,0.48,5e-06,5.30102999566398,"(SBP )",0.03,"[NR]  mmHg increase","Illumina [899,892]","N"]
["V4 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","11p15.1",11,20378124,"HTATIP2",null,120237,10553,null,196.25,7.11,"rs11025523-A","rs11025523",0,11025523,null,1,0.091,7e-06,5.15490195998574,"(Sedentary&light activity )",0.04,"[NR]  min/d increase","Illumina [899,892]","N"]
["V4 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","6p21.32",6,33489882,"BAK1",null,221504,578,null,64.56,50.44,"rs9469457-A","rs9469457",0,9469457,null,1,0.021,9e-06,5.04575749056067,"(Dinner intake, adj EER )",0.03,"[NR]  kcal increase","Illumina [899,892]","N"]
["V4 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","8p22",8,18707871,"PSD3","- ",null,null,23362,null,null,"rs7833787-A","rs7833787",0,7833787,"intron",0,0.474,5e-06,5.30102999566398,"(BMD )",0.04,"[NR]  g/cm2 increase","Illumina [899,892]","N"]
["V4 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","2q37.1",2,231035745,"SP110","- ",null,null,3431,null,null,"rs13010639-A","rs13010639",0,13010639,"intron",0,0.085,6e-06,5.22184874961635,"(BMR RQ)",0.04,"[NR]  unit increase","Illumina [899,892]","N"]
["V4 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","6p22.3",6,20382600,"E2F3",null,154141,1871,null,169.93,19.54,"rs1570155-A","rs1570155",0,1570155,null,1,0.391,4e-06,5.39794000867203,"(Calorimeter activity )",0.04,"[NR]  counts/d increase","Illumina [899,892]","N"]
["V4 (up-regulated)","01/29/2013",23149075,"Aslibekyan S","11/10/2012","Nutr Metab Cardiovasc Dis","http://www.ncbi.nlm.nih.gov/pubmed/23149075","Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network.","Response to fenofibrate (adiponectin levels)","793 European ancestry individuals","NA","12q24.13",12,113607502,"DDX54, TPCN1, SLC24A6, OAS1, OAS2, OAS3","- ",null,null,79039,null,null,"rs2384207-?","rs2384207",0,2384207,"intron",0,"NR",5e-08,7.30102999566398,"(Response)",0.06,"[0.040-0.080] ng/dL increase","Affymterix [2,543,887] (imputed)","N"]
["V4 (up-regulated)","01/30/2013",23144326,"Kim DK","11/09/2012","Am J Respir Crit Care Med","http://www.ncbi.nlm.nih.gov/pubmed/23144326","Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.","Chronic obstructive pulmonary disease-related biomarkers"," (up-regulated) to 1,951 European ancestry smokers","NR","6p21.33",6,31240431,"HLA-C","- ",null,null,3107,null,null,"rs2074488-T","rs2074488",0,2074488,"nearGene-5",0,0.13,2e-10,9.69897000433601,"(SP-D)","NR","NR","Illumina (588,352)","N"]
["V4 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Crohn's disease"," (up-regulated) to 12,924 European ancestry cases,  (up-regulated) to 21,442 European ancestry controls "," (up-regulated) to 25,683 European ancestry cases,  (up-regulated) to 17,015 European ancestry controls ","6p21.33",6,31274380,"HLA-C,PSORS1C1,NFKBIL1,MICB",null,387122,3106,null,17.44,47.27,"rs9264942-C","rs9264942",0,9264942,null,1,0.378,5e-28,27.3010299956639,null,1.15,"[1.107-1.184] ","Affyemtrix & Illumina [1.23 million] (imputed)","N"]
["V4 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Crohn's disease"," (up-regulated) to 12,924 European ancestry cases,  (up-regulated) to 21,442 European ancestry controls "," (up-regulated) to 25,683 European ancestry cases,  (up-regulated) to 17,015 European ancestry controls ","17q11.2",17,25843643,"LGALS9,NOS2","- ",null,null,8844,null,null,"rs2945412-A","rs2945412",0,2945412,"intron",0,0.587,9e-17,16.0457574905606,null,1.14,"[1.10-1.175] ","Affyemtrix & Illumina [1.23 million] (imputed)","N"]
["V4 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","9p24.1",9,4981602,"JAK2",null,406894,3717,null,131.23,3.64,"rs10758669-C","rs10758669",0,10758669,null,1,0.349,8e-45,44.096910013008,null,1.17,"[1.139-1.209] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V4 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","10p15.1",10,6081230,"IL2RA,IL15RA","- ",null,null,3559,null,null,"rs12722515-C","rs12722515",0,12722515,"intron",0,0.849,4e-10,9.39794000867203,null,1.1,"[1.06-1.147] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V4 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","2q24.2",2,163110536,"IFIH1",null,2191,64135,null,10.49,13.05,"rs2111485-A","rs2111485",0,2111485,null,1,0.404,2e-08,7.69897000433601,null,1.07,"[1.035-1.097] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V4 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","19q13.11",19,33731551,"CEBPG",null,56301,1050,null,14.8,59.29,"rs17694108-A","rs17694108",0,17694108,null,1,0.282,6e-15,14.2218487496163,null,1.1,"[1.065-1.135] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V4 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","2q32.3",2,191931464,"STAT1,STAT4","- ",null,null,6775,null,null,"rs1517352-C","rs1517352",0,1517352,"intron",0,0.6,3e-11,10.5228787452803,null,1.08,"[1.046-1.109] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V4 (up-regulated)","01/09/2013",23092984,"Goes FS","10/23/2012","Transl Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23092984","Genome-wide association of mood-incongruent psychotic bipolar disorder.","Bipolar disorder (mood-incongruent)","2,196 cases, 8,148 controls","NR","3p22.2",3,36856030,"TRANK1, LBA",null,645548,9881,null,45.65,12.28,"rs9834970-?","rs9834970",0,9834970,null,1,"NR",1e-07,7,null,1.22,"[NR] ","Affymetrix & Illumina [NR] (~2.5 Million)","N"]
["V4 (up-regulated)","12/21/2012",23042114,"Hirota T","10/07/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23042114","Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.","Atopic dermatitis","1,472 Japanese ancestry cases, 7,971 Japanese ancestry controls","1,856 Japanese ancestry cases, 7,021 Japanese ancestry controls","11q13.1",11,65513107,"OVOL1",null,390211,91056,null,17.62,28.26,"rs593982-C","rs593982",0,593982,null,1,0.53,6e-07,6.22184874961635,null,1.23,"[NR] ","Illumina [606,164]","N"]
["V4 (up-regulated)","12/21/2012",23042114,"Hirota T","10/07/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23042114","Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.","Atopic dermatitis","1,472 Japanese ancestry cases, 7,971 Japanese ancestry controls","1,856 Japanese ancestry cases, 7,021 Japanese ancestry controls","6p21.33",6,31272321,"HLA-C",null,387122,3106,null,15.38,49.33,"rs9368677-G","rs9368677",0,9368677,null,1,0.798,1e-17,17,null,1.36,"[1.27-1.46] ","Illumina [606,164]","N"]
["V4 (up-regulated)","12/06/2012",22993228,"Williams FM","09/19/2012","Ann Rheum Dis","http://www.ncbi.nlm.nih.gov/pubmed/22993228","Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.","Disc degeneration (lumbar)","4,683 European ancestry individuals","NR","6p21.32",6,32852647,"PSMB9",null,100507444,267017,null,4.8,11.53,"rs2187689-C","rs2187689",0,2187689,null,1,0.08,3e-08,7.52287874528033,null,0.23,"[0.15-0.31] unit increase","Affymetrix & Illumina [2,552,511] (imputed)","N"]
["V4 (up-regulated)","11/29/2012",23000144,"Nakamura M","09/18/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23000144","Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.","Primary biliary cirrhosis","487 Japanese ancestry cases, 476 Japanese ancestry controls","787 Japanese ancestry cases, 615 Japanese ancestry controls","11q23.1",11,111275133,"POU2AF1",null,5450,54766,null,24.98,63.12,"rs4938534-A","rs4938534",0,4938534,null,1,0.44,2e-08,7.69897000433601,null,1.39,"[1.24-1.56] ","Affymetrix [421,245]","N"]
["V4 (up-regulated)","11/30/2012",22976474,"Siddiq A","09/13/2012","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/22976474","A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11.","Breast cancer","3,666 European ancestry cases, 28,864 European ancestry controls, 1,004 African American cases, 2,744 African American controls","562 European ancestry cases, 6,410 European ancestry controls, 84 Japanese ancestry cases, 830 Japanese ancestry controls, 300 Hispanic/Latin American cases, 1,164 Hispanic/Latin American controls","20q11.22",20,32588095,"RALY, EIF2S2, ASIP","- ",null,null,22913,null,null,"rs2284378-T","rs2284378",0,2284378,"intron",0,0.31,1e-08,8,null,1.16,"[1.10-1.22] ","Illumina [2,608,509] (imputed)","N"]
["V4 (up-regulated)","12/06/2012",23028341,"Yang X","09/13/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23028341","Genome-wide association study for serum complement C3 and C4 levels in healthy Chinese subjects.","Complement C3 and C4 levels","1,999 Chinese Han men","1,496 Chinese Han men","6p21.33",6,31557791,"HLA-C","- ",null,null,259197,null,null,"rs11575839-A","rs11575839",0,11575839,"cds-synon",0,0.05,1e-54,53.9999999999999,"(Serum level of C4)",0.23,"[0.21-0.25] g/L decrease","Illumina [1,940,245] (imputed)","N"]
["V4 (up-regulated)","01/15/2013",23225573,"Buck D","09/08/2012","Ann Neurol","http://www.ncbi.nlm.nih.gov/pubmed/23225573","Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis.","IgG levels","229 European ancestry multiple sclerosis cases","409 European ancestry multiple sclerosis cases","14q32.33",14,106232585,"IGHG3, IGHG1, IGHG2","- ",null,null,3502,null,null,"rs10136766-A","rs10136766",0,10136766,null,0,0.27,8e-16,15.096910013008,null,0.23,"[NR] unit increase","Illumina [526,014]","N"]
["V4 (up-regulated)","11/02/2012",22941191,"Diskin SJ","09/02/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22941191","Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma.","Neuroblastoma","2,101 European ancestry cases, 4,202 European ancestry controls","351 Italian cases, 780 Italian controls, 365 African American cases, 2,491 African American controls","2q35",2,215653887,"BARD1","- ",null,null,580,null,null,"rs7587476-T","rs7587476",0,7587476,"intron",0,0.246,4e-14,13.397940008672,null,1.37,"[NR] ","Illumina [426,697]","N"]
["V4 (up-regulated)","11/16/2012",22936669,"Julia A","08/30/2012","Gut","http://www.ncbi.nlm.nih.gov/pubmed/22936669","A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.","Crohn's disease","1,277 European ancestry cases, 1,488 European ancestry controls","1,365 European ancestry cases, 1,396 European ancestry controls","22q13.2",22,41431342,"RBX1, EP300",null,9978,267009,null,62.32,28.66,"rs4820425-A","rs4820425",0,4820425,null,1,0.24,3e-08,7.52287874528033,null,1.27,"[1.17-1.38] ","Illumina [508,934]","N"]
["V4 (up-regulated)","11/02/2012",22939635,"Reiner AP","08/28/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/22939635","Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.","C-reactive protein","8,280 African American women, 3,548 Hispanic/Latin American ancestry women","3,787 African American women, 3,548 Hispanic/Latin American ancestry women, 5,656 European ancestry individuals","1q23.2",1,159649700,"CRP, APCS, DARC, FCER1A, DUSP23, OR10J1, OR10J5, OR10J3, OLFML2B, IFI16, FCRL6",null,401973,171422,null,80.69,25.04,"rs16827466-T","rs16827466",1,10494326,null,1,0.178,4e-73,72.397940008672,"(AA Women)",0.42,"[0.37-0.46] unit increase","Affymetrix [ (up-regulated) to 2,203,609] (imputed)","N"]
["V4 (up-regulated)","11/02/2012",22939635,"Reiner AP","08/28/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/22939635","Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.","C-reactive protein","8,280 African American women, 3,548 Hispanic/Latin American ancestry women","3,787 African American women, 3,548 Hispanic/Latin American ancestry women, 5,656 European ancestry individuals","12q24.31",12,121435587,"HNF1A, OASL, C12orf43","- ",null,null,6927,null,null,"rs2259816-T","rs2259816",0,2259816,"intron",0,0.379,3e-10,9.52287874528033,"(HA women)",0.14,"[0.092-0.190] unit increase","Affymetrix [ (up-regulated) to 2,203,609] (imputed)","N"]
["V4 (up-regulated)","11/02/2012",22939635,"Reiner AP","08/28/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/22939635","Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.","C-reactive protein","8,280 African American women, 3,548 Hispanic/Latin American ancestry women","3,787 African American women, 3,548 Hispanic/Latin American ancestry women, 5,656 European ancestry individuals","1q23.2",1,159698549,"CRP, APCS, DARC, FCER1A, DUSP23, OR10J1, OR10J5, OR10J3, OLFML2B, IFI16, FCRL6",null,1401,646446,null,14.17,30.39,"rs7553007-T","rs7553007",0,7553007,null,1,0.228,1e-37,37,"(AA women)",0.27,"[0.23-0.31] (unit decrease)","Affymetrix [ (up-regulated) to 2,203,609] (imputed)","N"]
["V4 (up-regulated)","11/02/2012",22939635,"Reiner AP","08/28/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/22939635","Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.","C-reactive protein","8,280 African American women, 3,548 Hispanic/Latin American ancestry women","3,787 African American women, 3,548 Hispanic/Latin American ancestry women, 5,656 European ancestry individuals","1q23.2",1,159692573,"CRP, APCS, DARC, FCER1A, DUSP23, OR10J1, OR10J5, OR10J3, OLFML2B, IFI16, FCRL6",null,1401,646446,null,8.19,36.36,"rs2808634-T","rs2808634",0,2808634,null,1,0.156,3e-10,9.52287874528033,"(AA women)",0.15,"[0.11-0.20] (unit decrease)","Affymetrix [ (up-regulated) to 2,203,609] (imputed)","N"]
["V4 (up-regulated)","11/21/2012",22916037,"Inouye M","08/16/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22916037","Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.","Metabolite levels","6,608 European ancestry individuals","NR","4q22.1",4,89226422,"PPM1K, HERC6",null,152926,55008,null,20.44,73.47,"rs1440581-?","rs1440581",0,1440581,null,1,0.47,1e-10,10,null,"NR","NR","Illumina [~2 million] (imputed)","N"]
["V4 (up-regulated)","09/29/2012",22883433,"Irish Schizophrenia Genomics Consortium & the Wellcome Trust Case Control Consortium 2","08/07/2012","Biol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22883433","Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia.","Schizophrenia","1,606 European ancestry cases, 1,794 European ancestry controls","13,195 European ancestry cases, 31,021 European ancestry controls","6p22.1",6,30165273,"MHC, TRIM26","- ",null,null,7726,null,null,"rs2523722-G","rs2523722",0,2523722,"intron",0,0.737,1e-16,16,null,1.25,"[1.12-1.39] ","Affymetrix [6,212,339]","N"]
["V4 (up-regulated)","09/14/2012",22780124,"Lind PA","07/11/2012","Addict Biol","http://www.ncbi.nlm.nih.gov/pubmed/22780124","Genome-wide association study of a quantitative disordered gambling trait.","Gambling","1,312 twins from 894 families","NR","6p22.3",6,16343056,"ATXN1, GMPR","- ",null,null,6310,null,null,"rs9383153-A","rs9383153",0,9383153,"intron",0,0.948,5e-06,5.30102999566398,null,0.33,"[0.19-0.47] unit increase","Illumina [2,373,249] (imputed)","N"]
["V4 (up-regulated)","09/12/2012",22792082,"Himes BE","07/05/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22792082","Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene.","Asthma (bronchodilator response)","1,644 European ancestry asthmatics","1,051 European ancestry asthmatics","2q33.1",2,201150040,"SPATS2L",null,79568,26010,null,321.19,20.56,"rs295137-T","rs295137",0,295137,null,1,0.41,1e-06,5.99999999999999,null,"NR","NR","Affymetrix & Illumina [4,571,615] (imputed)","N"]
["V4 (up-regulated)","08/07/2012",22704111,"Hotaling JM","06/13/2012","J Urol","http://www.ncbi.nlm.nih.gov/pubmed/22704111","Pilot genome-wide association search identifies potential loci for risk of erectile dysfunction in type 1 diabetes using the DCCT/EDIC study cohort.","Erectile dysfunction","125 European ancestry Erectile dysfunction cases with Type 1 Diabetes, 403 European ancestry non Erectile dysfunction controls with Type 1 Diabetes ","NR","3p12.2",3,80865764,"SLC25A36",null,100873895,100419178,null,858.47,795.63,"rs9850224-A","rs9850225",0,9850225,null,1,0.01,5e-08,7.30102999566398,null,"NR","NR","Illumina [840,354]","N"]
["V4 (up-regulated)","08/07/2012",22700719,"Slager SL","06/13/2012","Blood","http://www.ncbi.nlm.nih.gov/pubmed/22700719","Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia.","Chronic lymphocytic leukemia","1,121 European ancestry cases, 3,745 European ancestry controls","861 European ancestry cases, 2,033 European ancestry controls","6p21.31",6,33546837,"BAK1","- ",null,null,578,null,null,"rs210142-C","rs210142",0,210142,"intron",0,0.7,9e-16,15.0457574905606,null,1.4,"[1.25-1.57] ","Affymetrix & Illumina [~1,500,000] (imputed)","N"]
["V4 (up-regulated)","08/14/2012",22685421,"Fan Q","06/07/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22685421","Genetic variants on chromosome 1q41 influence ocular axial length and high myopia.","Myopia (pathological)","2,789 Singaporean Chinese ancestry individuals, 2,155 Singaporean Malay ancestry individuals","NR","2p16.2",2,54718181,"SPTBN1","- ",null,null,6711,null,null,"rs4557020-T","rs4557020",0,4557020,"intron",0,0.37,3e-07,6.52287874528033,null,0.12,"[0.081-0.159] mm decrease","Illumina [456,634]","N"]
["V4 (up-regulated)","07/17/2012",22658654,"Chung SJ","05/30/2012","Parkinsonism Relat Disord","http://www.ncbi.nlm.nih.gov/pubmed/22658654","Genomic determinants of motor and cognitive outcomes in Parkinson's disease.","Parkinson's disease (motor and cognition)","443 European ancestry cases","NR","5q23.2",5,126181862,"LMNB1",null,4001,115123,null,9.15,21.54,"rs959573-?","rs959573",0,959573,null,1,"NR",5e-06,5.30102999566398,"(cognitive outcome)",1.92,"[1.49-2.50] ","NR [198,345]","N"]
["V4 (up-regulated)","08/17/2012",22589738,"Fox CS","05/10/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22589738","Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.","Visceral adipose tissue adjusted for BMI","5,560 European ancestry women and 4,997 European ancestry men","NR","12q24.13",12,113491784,"DTX1, OAS2, RASAL1",null,4939,100271649,null,42.26,0.08,"rs7956193-T","rs7956193",0,7956193,null,1,0.29,1e-06,5.99999999999999,"(women)","NR","NR","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V4 (up-regulated)","08/17/2012",22589738,"Fox CS","05/10/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22589738","Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.","Visceral adipose tissue adjusted for BMI","5,560 European ancestry women and 4,997 European ancestry men","NR","6p21.33",6,31377587,"HLA-B, HCP5","- ",null,null,100507436,null,null,"rs12175489-A","rs12175489",0,12175489,"intron",0,0.15,2e-06,5.69897000433601,"(men)","NR","NR","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V4 (up-regulated)","08/17/2012",22589738,"Fox CS","05/10/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22589738","Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.","Visceral adipose tissue adjusted for BMI","5,560 European ancestry women and 4,997 European ancestry men","NR","7p21.3",7,7302293,"C1GALT1",null,56913,340267,null,14.04,95.95,"rs1299548-A","rs1299548",0,1299548,null,1,0.46,4e-06,5.39794000867203,"(men)","NR","NR","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V4 (up-regulated)","07/11/2012",22561518,"Jin Y","05/06/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22561518","Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.","Vitiligo","418 European ancestry cases, 2,810 European ancestry controls        ","1,377 European ancestry cases, 1,284 European ancestry controls","2q24.2",2,163110536,"IFIH1",null,2191,64135,null,10.49,13.05,"rs2111485-G","rs2111485",0,2111485,null,1,0.62,5e-15,14.3010299956639,null,1.3,"[NR] ","Illumina [495,821]","N"]
["V4 (up-regulated)","04/11/2013",22504420,"Estrada K","04/15/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22504420","Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.","Bone mineral density"," (up-regulated) to 32,961 European and East Asian ancestry individuals"," (up-regulated) to 50,933 European and East Asian ancestry individuals","2p16.2",2,54659707,"SPTBN1",null,129852,56969,null,70.99,96.65,"rs4233949-C","rs4233949",0,4233949,null,1,0.38,2e-18,17.698970004336,"(LSBMD)",0.05,"[NR] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V4 (up-regulated)","05/25/2012",22493691,"Eriksson N","04/06/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/22493691","Novel associations for hypothyroidism include known autoimmune risk loci.","Hypothyroidism","3,736 European ancestry cases, 35,546 European ancestry controls","NR","6p21.33",6,31018407,"LOC729792, HCG22, C6orf15, HLA-C, HLA-B, DHFRP2, HCP5",null,100507679,285834,null,15.23,2.82,"rs2517532-G","rs2517532",0,2517532,null,1,0.597,1e-08,8,null,1.16,"[1.10-1.22] ","Illumina [870,065]","N"]
["V4 (up-regulated)","04/27/2012",22424883,"Imboden M","03/15/2012","J Allergy Clin Immunol","http://www.ncbi.nlm.nih.gov/pubmed/22424883","Genome-wide association study of lung function decline in adults with and without asthma.","Pulmonary function decline","1,441 European ancestry asthma cases, 2,677 European ancestry controls","1,160 European ancestry asthma cases, 10,858 European ancestry controls","4q22.1",4,89421086,"HERC5","- ",null,null,51191,null,null,"rs10516809-?","rs10516809",0,10516809,"cds-synon",0,"NR",9e-06,5.04575749056067,"(FEV1 decline in asthmatics)",0.31,"[0.17-0.44] unit increase","Illumina [~2.5 million] (imputed)","N"]
["V4 (up-regulated)","04/03/2012",22412388,"Kenny EE","03/08/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22412388","A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.","Crohn's disease","737 Ashkenazi Jewish cases, 2,257  Ashkenazi Jewish controls","971 Ashkenazi Jewish cases, 2,124 Ashkenazi Jewish controls","16q22.1",16,67971380,"PSMB10","- ",null,null,5699,null,null,"rs11574514-A","rs11574514",0,11574514,"nearGene-5",0,0.045,2e-07,6.69897000433601,null,1.44,"[1.35-1.52] ","Affyemtrix & Illumina [1,060,934] (imputed)","N"]
["V4 (up-regulated)","04/03/2012",22412388,"Kenny EE","03/08/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22412388","A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.","Crohn's disease","737 Ashkenazi Jewish cases, 2,257  Ashkenazi Jewish controls","971 Ashkenazi Jewish cases, 2,124 Ashkenazi Jewish controls","6p22.1",6,29723161,"HLA-F, MOG, HLA-G, GABBR1, HLA-H, UBD, HLA-A",null,340198,353010,null,4.24,9.73,"rs9258260-T","rs9258260",0,9258260,null,1,0.104,2e-10,9.69897000433601,null,1.45,"[1.21-1.68] ","Affyemtrix & Illumina [1,060,934] (imputed)","N"]
["V4 (up-regulated)","04/03/2012",22423221,"Qayyum R","03/08/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22423221","A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.","Mean platelet volume","16,388 African American individuals","NR","6p21.31",6,33540209,"BAK1","- ",null,null,578,null,null,"rs210134-G","rs210134",0,210134,"nearGene-3",0,0.286,2e-15,14.698970004336,"(Platelet Count)",6.16,"[4.63-7.69] 10^9 L decrease","Affymetrix & Illumina [~2.2 million](imputed)","N"]
["V4 (up-regulated)","04/03/2012",22399527,"Kristiansson K","03/07/2012","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/22399527","Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.","Metabolic syndrome","2,637 European ancestry cases, 7,927 European ancestry controls","NR","6p21.33",6,31448976,"HCG26, MICB",null,352961,4277,null,8.79,16.88,"rs3099844-A","rs3099844",0,3099844,null,1,0.08,2e-08,7.69897000433601,"(HDL)",0.15,"[NR] mmol/l decrease","Illumina [1,257,079] (imputed)","N"]
["V4 (up-regulated)","03/14/2012",22331829,"Chasman DI","02/13/2012","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/22331829","Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (J (up-regulated)ITER) trial.","Response to statin therapy (LDL-C)","6,989 European ancestry individuals","NR","6p22.3",6,16161425,"GMPR, IDOL, MYLIP",null,100616269,346116,null,19.57,10.41,"rs6924995-?","rs6924995",0,6924995,null,1,"NR",5e-07,6.30102999566398,"(absolute LDL-C reduction)",4.1,"[2.73-5.47] mg/dL increase","Illumina [814,418]","N"]
["V4 (up-regulated)","03/08/2012",22319020,"Davies RW","02/07/2012","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/22319020","A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.","Coronary heart disease","7,123 European ancestry cases, 6,826 European ancestry controls","5,211 European ancestry cases, 5,821 European ancestry controls","6p21.33",6,31184196,"HCG27, HLA-C",null,253018,100287272,null,12.45,59.16,"rs3869109-G","rs3869109",0,3869109,null,1,"NR",1e-09,8.99999999999999,null,1.14,"[NR] ","Affymetrix [~5 million] (imputed)","N"]
["V4 (up-regulated)","02/23/2012",22286212,"Urayama KY","01/27/2012","J Natl Cancer Inst","http://www.ncbi.nlm.nih.gov/pubmed/22286212","Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgro (up-regulated)s.","Hodgkin's lymphoma","1,200 European ancestry cases, 6,417 European ancestry controls","563 European ancestry cases, 613 European ancestry controls","6p21.33",6,31446796,"MICB",null,352961,4277,null,6.61,19.06,"rs2248462-?","rs2248462",0,2248462,null,1,"NR",7e-16,15.1549019599857,"(Total cHL)",1.64,"[1.45-1.85] ","Illumina [502,514]","N"]
["V4 (up-regulated)","01/28/2012",22197932,"Paternoster L","12/25/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22197932","Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.","Atopic dermatitis","5,606 European ancestry cases, 20,565 European ancestry controls","5,419 European ancestry cases, 19,833 European ancestry controls","11q13.1",11,65551957,"OVOL1",null,91056,5017,null,3.9,2.55,"rs479844-G","rs479844",0,479844,null,1,0.56,1e-13,13,null,1.14,"[1.10-1.18] ","Afftmetrix & Illumina [~2.5 million] (imputed)","N"]
["V4 (up-regulated)","01/27/2012",22182935,"Chen DT","12/20/2011","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22182935","Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.","Bipolar disorder","5,568 European ancestry cases, 7,187 European ancestry controls, 1,000 Taiwanese cases, 1,000 Taiwanese controls","1,115 European ancestry cases, 2,728 European ancestry controls","3p22.2",3,36856030,"TRANK1",null,645548,9881,null,45.65,12.28,"rs9834970-C","rs9834970",0,9834970,null,1,"NR",1e-12,12,null,"NR","NR","Affymetrix & Illumina [748,555]","N"]
["V4 (up-regulated)","01/17/2012",22190364,"Patsopoulos NA","12/01/2011","Ann Neurol","http://www.ncbi.nlm.nih.gov/pubmed/22190364","Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.","Multiple sclerosis","5,545 European ancestry cases, 12,153 European ancestry controls","NR","17q21.32",17,45768836,"KPNB1, TBKBP1, TBX21",null,3837,9755,null,7.83,3.79,"rs8070463-T","rs8070463",0,8070463,null,1,0.5,1e-07,7,null,1.15,"[NR] ","Affymetrix & Illumina [2,529,394]","N"]
["V4 (up-regulated)","01/17/2012",22190364,"Patsopoulos NA","12/01/2011","Ann Neurol","http://www.ncbi.nlm.nih.gov/pubmed/22190364","Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.","Multiple sclerosis","5,545 European ancestry cases, 12,153 European ancestry controls","NR","6p22.1",6,29920332,"HLA-B",null,3105,353002,null,6.67,2.65,"rs9260489-T","rs9260489",0,9260489,null,1,0.45,1e-11,11,null,1.21,"[NR] ","Affymetrix & Illumina [2,529,394]","N"]
["V4 (up-regulated)","11/16/2012",22139419,"Gieger C","11/30/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/22139419","New gene functions in megakaryopoiesis and platelet formation.","Platelet counts","48,666 individuals of European ancestry"," (up-regulated) to 18,838 individuals of European ancestry","6p21.33",6,31322367,"HLA-B","- ",null,null,3106,null,null,"rs3819299-G","rs3819299",0,3819299,"intron",0,"NR",9e-10,9.04575749056067,null,5.05,"[3.43-6.66] 10^9/l increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V4 (up-regulated)","11/16/2012",22139419,"Gieger C","11/30/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/22139419","New gene functions in megakaryopoiesis and platelet formation.","Platelet counts","48,666 individuals of European ancestry"," (up-regulated) to 18,838 individuals of European ancestry","6p21.31",6,33540209,"BAK1","- ",null,null,578,null,null,"rs210134-G","rs210134",0,210134,"nearGene-3",0,"NR",7e-36,35.1549019599857,null,4.96,"[4.18-5.73] 10^9/l increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V4 (up-regulated)","12/16/2011",22075330,"Granada M","11/08/2011","J Allergy Clin Immunol","http://www.ncbi.nlm.nih.gov/pubmed/22075330","A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.","IgE levels ","6,819 European ancestry individuals","7,809 European ancestry indivduals","6p22.1",6,29849619,"HLA-G",null,353009,353004,null,14.76,4.27,"rs2523809-T","rs2523809",0,2523809,null,1,"NR",4e-08,7.39794000867203,null,0.06,"[NR] unit increase","Affymetrix [2,540,223] (imputed)","N"]
["V4 (up-regulated)","11/09/2011",22001756,"Khor CC","10/16/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22001756","Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.","Dengue shock syndrome ","2,008 Vietnamese ancestry cases, 2,018 Vietnamese ancestry controls","1,737 Vietnamese ancestry cases, 2,934 Vietnamese ancestry controls","6p21.33",6,31475486,"MICB","- ",null,null,4277,null,null,"rs3132468-?","rs3132468",0,3132468,"intron",0,0.13,4e-11,10.397940008672,null,1.34,"[1.23-1.46] ","Illumina [481,342]","N"]
["V4 (up-regulated)","12/10/2011",21983787,"Barrett JH","10/09/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21983787","Genome-wide association study identifies three new melanoma susceptibility loci.","Melanoma","2,804 European ancestry cases, 7,618 European ancestry controls","5,551 European ancestry cases, 7,449 European ancestry controls","21q22.3",21,42746081,"MX2","- ",null,null,4600,null,null,"rs45430-?","rs45430",0,45430,"intron",0,0.61,3e-09,8.52287874528033,null,1.14,"[1.09-1.18] ","Illumina [594,997]","N"]
["V4 (up-regulated)","10/16/2011",21946350,"Soler Artigas M","09/25/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21946350","Genome-wide association and large-scale follow  (up-regulated) identifies 16 new loci influencing lung function.","Pulmonary function","48,201 European ancestry individuals","46,411 European ancestry individuals","1p36.13",1,17306675,"MFAP2","- ",null,null,4237,null,null,"rs2284746-G","rs2284746",0,2284746,"intron",0,0.52,8e-16,15.096910013008,"(FEV1/FVC)",0.04,"[0.030-0.050] unit decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V4 (up-regulated)","10/18/2011",21946350,"Soler Artigas M","09/25/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21946350","Genome-wide association and large-scale follow  (up-regulated) identifies 16 new loci influencing lung function.","Pulmonary function","48,201 European ancestry individuals","46,411 European ancestry individuals","6p21.33",6,31472720,"MICB","- ",null,null,4277,null,null,"rs2855812-T","rs2855812",0,2855812,"intron",0,"NR",2e-07,6.69897000433601,"(FEV1)",0.03,"[0.018-0.042] unit decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V4 (up-regulated)","10/20/2011",21943158,"Middelberg RP","09/24/2011","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/21943158","Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.","Cardiovascular disease risk factors","11,683 individuals","NR","12q24.31",12,121471337,"OASL","- ",null,null,8638,null,null,"rs3213545-A","rs3213545",0,3213545,"cds-synon",0,0.3,4e-15,14.397940008672,"(GGT)",0.12,"[0.092-0.150] units/l decrease","Illumina [NR] (imputed)","N"]
["V4 (up-regulated)","10/17/2011",21926974,"Ripke S","09/18/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21926974","Genome-wide association study identifies five new schizophrenia loci.","Schizophrenia","9,394 European ancestry cases, 12,462 European ancestry controls","8,442 European ancestry cases, 21,397 European ancestry controls","6p22.1",6,30174131,"TRIM26","- ",null,null,7726,null,null,"rs2021722-C","rs2021722",0,2021722,"intron",0,0.78,2e-12,11.698970004336,null,1.15,"[1.11-1.19] ","Affymetrix & Illumina [1,252,901] (imputed)","N"]
["V4 (up-regulated)","10/07/2011",21912425,"Tohkin M","09/13/2011","Pharmacogenomics J","http://www.ncbi.nlm.nih.gov/pubmed/21912425","A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients.","Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN)","14 Japanese ancestry cases, 991 Japanese ancestry controls","NR","6p21.33",6,31505480,"BAT1, HCP5, MICC, PPIAP9, PSORS1C1, POLR2LP, CCHCR1, TCF19, POU5F1, HLA-C, HCP5, PSORS1C3, HLA-B*5801","- ",null,null,"7919;692233;100532737",null,null,"rs2734583-?","rs2734583",0,2734583,"intron;nearGene-5;intron",0,0.0055,2e-08,7.69897000433601,null,66.8,"[19.8-225.0] ","Illumina [890,321]","N"]
["V4 (up-regulated)","10/11/2011",21909109,"Kim YJ","09/11/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21909109","Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.","HDL cholesterol","12,545 Korean ancestry individuals"," (up-regulated) to 30,395 East Asian ancestry individuals","12q24.13",12,113409176,"OAS3","- ",null,null,4940,null,null,"rs2072134-A","rs2072134",0,2072134,"UTR-3",0,0.11,6e-06,5.22184874961635,null,0.02,"[0.012-0.029] mg/dL decrease","Affymetrix [~2.2 million] (imputed)","N"]
["V4 (up-regulated)","09/21/2011",21841780,"Chu X","08/14/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21841780","A genome-wide association study identifies two new risk loci for Graves' disease.","Graves' disease","1,468 Chinese ancestry cases, 1,490 Chinese ancestry controls","3,994 Chinese ancestry cases, 3,510 Chinese ancestry controls","6p21.33",6,31350704,"HLA-B",null,267015,100507436,null,0.44,16.86,"rs1521-T","rs1521",0,1521,null,1,0.79,2e-65,64.698970004336,null,1.92,"[1.78-2.08] ","Illumina [486,049]","N"]
["V4 (up-regulated)","10/24/2012",21833088,"Sawcer S","08/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21833088","Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.","Multiple sclerosis","9,772 European ancestry cases, 16,849 European ancestry controls","4,218 European ancestry cases, 7,296 European ancestry controls","22q13.33",22,50971266,"ODF3B, SCO2","- ",null,null,440836,null,null,"rs140522-A","rs140522",0,140522,"nearGene-5",0,"NR",2e-08,7.69897000433601,null,1.1,"[1.09-1.12] ","Illumina [465,434]","N"]
["V4 (up-regulated)","09/21/2011",21829393,"Plagnol V","08/04/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21829393","Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.","Type 1 diabetes autoantibodies","12,501 European ancestry cases","3,598 affected siblings","2q24.2",2,163124051,"IFIH1","- ",null,null,64135,null,null,"rs1990760-C","rs1990760",0,1990760,"missense",0,"NR",2e-14,13.698970004336,"(T1D)",1.2,"[NR] ","Affymetrix and Illumina [NR]","N"]
["V4 (up-regulated)","07/30/2011",21743469,"Evans DM","07/10/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21743469","Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.","Ankylosing spondylitis","3,023 European ancestry cases, 8,779 European ancestry controls","2,111 European ancestry cases, 4,483 European ancestry controls","6p21.33",6,31365787,"HLA-B",null,267015,100507436,null,15.52,1.77,"rs4349859-A","rs4349859",0,4349859,null,1,0.04,1e-200,200,"(less than)","NR","NR","Illumina [2,223,620] (imputed)","N"]
["V4 (up-regulated)","03/03/2012",21732829,"Dolmans GH","07/06/2011","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/21732829","Wnt signaling and D (up-regulated)uytren's disease.","D (up-regulated)uytren's disease","856 European ancestry cases, 2,836 European ancestry controls","1,298 European ancestry cases, 7,136 European ancestry controls","15q26.1",15,89245239,"ISG20",null,3669,176,null,46.36,101.44,"rs4932194-?","rs4932194",0,4932194,null,1,0.69,8e-07,6.09691001300805,null,1.22,"[1.12-1.3] ","Illumina [234,939]","N"]
["V4 (up-regulated)","07/20/2011",21738487,"Do CB","06/23/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21738487","Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.","Parkinson's disease","3,426 cases, 29,624 controls","NR","4q21.1",4,77198986,"SCARB2","- ",null,null,"100129583;100631383",null,null,"rs6812193-C","rs6812193",0,6812193,"intron;intron",0,0.64,8e-10,9.09691001300805,null,1.19,"[1.12-1.27] ","Illumina [522,782]","N"]
["V4 (up-regulated)","06/29/2011",21653640,"Eleftherohorinou H","06/13/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21653640","Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways.","Rheumatoid arthritis","2768 European ancestry cases, 4198 European ancestry controls","NR","6p22.1",6,29789171,"HLA-G",null,352967,353005,null,8.7,4.74,"rs1610677-?","rs1610677",0,1610677,null,1,"NR",4e-15,14.397940008672,null,1.32,"[1.79-1.41] ","Affymetrix & Illumina [NR]","N"]
["V4 (up-regulated)","05/27/2011",21546767,"Murea M","05/05/2011","Am J Nephrol","http://www.ncbi.nlm.nih.gov/pubmed/21546767","Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.","Dialysis-related mortality","610 African American type 2 diabetics","NR","7p15.3",7,22514053,"IL6, RAPGEF5","- ",null,null,256227,null,null,"rs17364464-?","rs17364464",0,17364464,"intron",0,0.08,4e-06,5.39794000867203,null,1.76,"[1.38-2.25] ","Affymetrix [832,357]","N"]
["V4 (up-regulated)","06/01/2011",21507922,"Ramsuran V","05/01/2011","Clin Infect Dis","http://www.ncbi.nlm.nih.gov/pubmed/21507922","Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.","Neutrophil count","115 African ancestry HIV-negative individuals","NR","8p22",8,18782047,"PSD3","- ",null,null,23362,null,null,"rs4921617-?","rs4921617",0,4921617,"intron",0,"NR",4e-06,5.39794000867203,null,"NR","NR","Illumina [874,956]","N"]
["V4 (up-regulated)","05/24/2011",21490949,"Sim X","04/07/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21490949","Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.","Type 2 diabetes","2,010 Chinese ancestry cases, 1,945 Chinese ancestry controls, 794 Malaysian ancestry cases, 1,240 Malyasian ancestry controls, 977 Asian Indian ancestry cases, 1,169 Asian Indian ancestry controls","NR","10q23.33",10,94347830,"KIF11",null,3416,100271272,null,13.98,8.78,"rs6583826-G","rs6583826",0,6583826,null,1,0.26,7e-06,5.15490195998574,"(Chinese+Malay+Indian)",1.18,"[1.10-1.27] ","Illumina [~2,000,000] (imputed)","N"]
["V4 (up-regulated)","05/24/2011",21490949,"Sim X","04/07/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21490949","Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.","Type 2 diabetes","2,010 Chinese ancestry cases, 1,945 Chinese ancestry controls, 794 Malaysian ancestry cases, 1,240 Malyasian ancestry controls, 977 Asian Indian ancestry cases, 1,169 Asian Indian ancestry controls","NR","4q32.3",4,164532801,41334,"- ",null,null,55016,null,null,"rs3792615-T","rs3792615",0,3792615,"intron",0,0.95,9e-06,5.04575749056067,"(Indian)",1.93,"[1.45-2.59] ","Illumina [~2,000,000] (imputed)","N"]
["V4 (up-regulated)","04/12/2011",21399633,"Gharavi AG","03/13/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21399633","Genome-wide association study identifies susceptibility loci for IgA nephropathy.","Nephropathy","1,194 Chinese ancestry cases, 902 Chinese ancestry controls","712 Chinese ancestry cases, 748 Chinese ancestry controls, 1,238 European ancestry cases, 1,172 European ancestry controls","6p21.32",6,32809848,"TAP2, TAP1, PSMB8, PSMB9","- ",null,null,5696,null,null,"rs9357155-?","rs9357155",0,9357155,"intron",0,"0.87 (EA)",2e-12,11.698970004336,null,1.41,"[NR] ","Illumina [498,322]","N"]
["V4 (up-regulated)","04/06/2011",21383967,"Zhernakova A","02/24/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21383967","Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.","Celiac disease and Rheumatoid arthritis","4,533 European ancestry celiac disease cases, 5,539 European ancestry rheumatoid arthritis cases, 27,981 European ancestry controls","2,169 celiac disease cases, 2,845 rheumatoid arthritis cases, 7,199 controls","1q23.1",1,159005649,"IFI16","- ",null,null,3428,null,null,"rs1772408-?","rs1772408",0,1772408,"intron",0,"NR",8e-07,6.09691001300805,null,"NR","NR","Illumina [472,854]","N"]
["V4 (up-regulated)","04/04/2011",21314694,"Kendler KS","02/11/2011","Alcohol Clin Exp Res","http://www.ncbi.nlm.nih.gov/pubmed/21314694","Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.","Alcohol dependence","2,357 European ancestry individuals, 812 African American individuals","NR","1q44",1,247348189,"ZNF124",null,100312805,729806,null,3.92,5.02,"rs3738443-A","rs3738443",0,3738443,null,1,0.03,4e-06,5.39794000867203,"(AA)","NR","NR","Affymetrix [NR]","N"]
["V4 (up-regulated)","03/29/2011",21297633,"Anderson CA","02/06/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21297633","Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.","Ulcerative colitis","6,687 European ancestry cases, 19,718 European ancestry controls","9,628 European ancestry cases, 12,917 European ancestry controls","9p24.1",9,4981602,"JAK2",null,406894,3717,null,131.23,3.64,"rs10758669-C","rs10758669",0,10758669,null,1,0.35,2e-25,24.698970004336,null,1.17,"[1.12-1.21] ","Affymetrix & Illumina [~1.1 million] (imputed)","N"]
["V4 (up-regulated)","03/29/2011",21297633,"Anderson CA","02/06/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21297633","Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.","Ulcerative colitis","6,687 European ancestry cases, 19,718 European ancestry controls","9,628 European ancestry cases, 12,917 European ancestry controls","3p21.31",3,49719729,"MST1, UBA7, APEH, AMIGO3, GMPPB, BSN","- ",null,null,327,null,null,"rs9822268-A","rs9822268",0,9822268,"intron",0,0.3,2e-17,16.698970004336,null,1.21,"[1.16-1.26] ","Affymetrix & Illumina [~1.1 million] (imputed)","N"]
["V4 (up-regulated)","03/28/2011",21348951,"Parsa A","02/01/2011","Clin Transl Sci","http://www.ncbi.nlm.nih.gov/pubmed/21348951","Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.","Cardiac hypertrophy","851 Old Order Amish individuals",null,"13q14.2",13,50080847,"PHF11","- ",null,null,51131,null,null,"rs2031532-?","rs2031532",0,2031532,"cds-synon",0,"NR",5e-06,5.30102999566398,"(recessive)","NR","NR","Affymetrix [361,034]","N"]
["V4 (up-regulated)","03/28/2011",21348951,"Parsa A","02/01/2011","Clin Transl Sci","http://www.ncbi.nlm.nih.gov/pubmed/21348951","Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.","Cardiac hypertrophy","851 Old Order Amish individuals",null,"6p22.1",6,30093364,"TRIM38",null,11074,135644,null,12.5,11.15,"rs10947055-?","rs10947055",0,10947055,null,1,"NR",2e-07,6.69897000433601,"(additive, recessive)","NR","NR","Affymetrix [361,034]","N"]
["V4 (up-regulated)","03/28/2011",21270382,"Baik I","01/26/2011","Am J Clin Nutr","http://www.ncbi.nlm.nih.gov/pubmed/21270382","Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men.","Alcohol consumption","1,721 Korean male drinkers","1,113 Korean male drinkers","12q24.13",12,113409176,"OAS3","- ",null,null,4940,null,null,"rs2072134-A","rs2072134",0,2072134,"UTR-3",0,0.11,6e-17,16.2218487496163,null,0.61,"[0.49-0.73] unit decrease","Affymetrix [315,914]","N"]
["V4 (up-regulated)","01/15/2011",21203500,"Lauc G","12/23/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21203500","Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1&#x003b1; as a master regulator of plasma protein fucosylation.","N-glycan levels","1,822 Croatian individuals, 737 Scottish individuals","NR","12q24.31",12,121403724,"HNF1A,C12orf43,OASL",null,643550,283460,null,48.64,3.92,"rs7953249-G","rs7953249",0,7953249,null,1,0.45,2e-08,7.69897000433601,"(DG7)",0.17,"[0.11-0.23] unit decrease","Illumina [~300,000]","N"]
["V4 (up-regulated)","01/15/2011",21203500,"Lauc G","12/23/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21203500","Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1&#x003b1; as a master regulator of plasma protein fucosylation.","N-glycan levels","1,822 Croatian individuals, 737 Scottish individuals","NR","12q24.31",12,121438844,"HNF1A,C12orf43,OASL","- ",null,null,6927,null,null,"rs735396-G","rs735396",0,735396,"intron",0,0.38,4e-08,7.39794000867203,"(DG11)",0.17,"[0.11-0.23] unit increase","Illumina [~300,000]","N"]
["V4 (up-regulated)","01/11/2011",21124317,"Wang K","12/01/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21124317","Integrative genomics identifies LMO1 as a neuroblastoma oncogene.","Neuroblastoma","1,627 European ancestry child cases, 3,254 European ancestry child controls","624 European ancestry child cases, 2,843 European ancestry child controls","2q35",2,215635794,"BARD1","- ",null,null,580,null,null,"rs3768716-C","rs3768716",0,3768716,"intron",0,0.23,5e-13,12.3010299956639,null,1.39,"[NR] ","Illumina [480,279]","N"]
["V4 (up-regulated)","01/12/2011",21116278,"Furney SJ","11/30/2010","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/21116278","Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.","Total ventricular volume"," (up-regulated) to 434 Caucasian MCI cases, 236 Caucasian AD cases, 284 Caucasian controls","NR","3q29",3,196553867,"PAK2","- ",null,null,5062,null,null,"rs2084385-?","rs2084385",0,2084385,"intron",0,"NR",5e-06,5.30102999566398,null,0.01,"[NR] unit increase (interaction)","Illumina [488,911]","N"]
["V4 (up-regulated)","10/19/2012",21102463,"Franke A","11/21/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21102463","Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.","Crohn's disease","6,333 European ancestry cases, 15,056 European ancestry controls","15,694 European ancestry cases, 14,026 European ancestry controls, 414 European ancestry parent-offspring trios","9p24.1",9,4981602,"JAK2",null,406894,3717,null,131.23,3.64,"rs10758669-C","rs10758669",0,10758669,null,1,0.349,1e-13,13,null,1.18,"[1.13-1.23] ","Affymetrix & Illumina [953,241] (imputed)","N"]
["V4 (up-regulated)","10/19/2012",21102463,"Franke A","11/21/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21102463","Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.","Crohn's disease","6,333 European ancestry cases, 15,056 European ancestry controls","15,694 European ancestry cases, 14,026 European ancestry controls, 414 European ancestry parent-offspring trios","1q22",1,155230131,"SCAMP3,MUC1","- ",null,null,10067,null,null,"rs3180018-A","rs3180018",1,1142287,"cds-synon",0,0.25,2e-13,12.698970004336,null,1.13,"[1.06-1.19] ","Affymetrix & Illumina [953,241] (imputed)","N"]
["V4 (up-regulated)","01/13/2011",21051598,"Pereyra F","11/04/2010","Science","http://www.ncbi.nlm.nih.gov/pubmed/21051598","The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.","HIV-1 control","516 European cases, 1,196 European controls, 341 African American cases, 892 African American controls, 117 Hispanic controls, 560 Hispanic controls","NR","6p21.33",6,31274380,"HLA-C",null,387122,3106,null,17.44,47.27,"rs9264942-C","rs9264942",0,9264942,null,1,0.34,3e-35,34.5228787452803,"(European)",2.9,"[NR] ","Illumina [1,384,048] (imputed)","N"]
["V4 (up-regulated)","01/13/2011",21051598,"Pereyra F","11/04/2010","Science","http://www.ncbi.nlm.nih.gov/pubmed/21051598","The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.","HIV-1 control","516 European cases, 1,196 European controls, 341 African American cases, 892 African American controls, 117 Hispanic controls, 560 Hispanic controls","NR","6p21.33",6,31327064,"HLA-B",null,3106,729816,null,2.08,4.18,"rs2523590-C","rs2523590",0,2523590,null,1,0.164,2e-13,12.698970004336,"(African American)",2.4,"[NR] ","Illumina [1,384,048] (imputed)","N"]
["V4 (up-regulated)","01/13/2011",21051598,"Pereyra F","11/04/2010","Science","http://www.ncbi.nlm.nih.gov/pubmed/21051598","The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.","HIV-1 control","516 European cases, 1,196 European controls, 341 African American cases, 892 African American controls, 117 Hispanic controls, 560 Hispanic controls","NR","6p21.33",6,31322559,"HLA-B","- ",null,null,3106,null,null,"rs2523608-G","rs2523608",0,2523608,"intron",0,0.326,9e-20,19.0457574905606,"(African American)",2.6,"[NR] ","Illumina [1,384,048] (imputed)","N"]
["V4 (up-regulated)","01/13/2011",21051598,"Pereyra F","11/04/2010","Science","http://www.ncbi.nlm.nih.gov/pubmed/21051598","The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.","HIV-1 control","516 European cases, 1,196 European controls, 341 African American cases, 892 African American controls, 117 Hispanic controls, 560 Hispanic controls","NR","6p21.33",6,31431780,"HLA-B","- ",null,null,10866,null,null,"rs2395029-G","rs2395029",0,2395029,"ncRNA",0,0.032,1e-25,25,"(European)",5.3,"[NR] ","Illumina [1,384,048] (imputed)","N"]
["V4 (up-regulated)","12/01/2010",20953188,"Ellinghaus E","10/17/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20953188","Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.","Psoriasis","472 German cases, 1,146 German controls","6,015 cases, 6,891 controls","6p21.33",6,31252925,"HLA-C",null,116935,387122,null,3.58,2.24,"rs12191877-?","rs12191877",0,12191877,null,1,"NR",4e-32,31.397940008672,null,2.79,"[2.35-3.33] (Panel A)","Illumina [2,339,118] (imputed)","N"]
["V4 (up-regulated)","11/30/2010",20953186,"Huffmeier U","10/17/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20953186","Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.","Psoriatic arthritis","572 German cases, 888 German controls"," (up-regulated) to 1,761 European descent cases, 3,727 European descent controls","6p21.33",6,31241109,"HLA-C","- ",null,null,3107,null,null,"rs13191343-T","rs13191343",0,13191343,"nearGene-5",0,0.13,2e-72,71.698970004336,null,2.37,"[2.16-2.61] ","Affymetrix [1,585,307] (imputed)","N"]
["V4 (up-regulated)","01/18/2011",20953190,"Strange A","10/17/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20953190","A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.","Psoriasis","2,178 European ancestry cases, 5,175 European ancestry controls","3,174 European ancestry cases, 5,464 European ancestry controls","6p21.33",6,31274555,"HLA-C",null,387122,3106,null,17.61,47.09,"rs10484554-?","rs10484554",0,10484554,null,1,"NR",4e-214,213.397940008672,null,4.66,"[4.23-5.13] ","Illumina [535,475]","N"]
["V4 (up-regulated)","01/18/2011",20953190,"Strange A","10/17/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20953190","A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.","Psoriasis","2,178 European ancestry cases, 5,175 European ancestry controls","3,174 European ancestry cases, 5,464 European ancestry controls","2q24.2",2,163260691,"IFIH1","- ",null,null,90134,null,null,"rs17716942-A","rs17716942",0,17716942,"intron",0,0.86,1e-13,13,null,1.29,"[1.17-1.43] ","Illumina [535,475]","N"]
["V4 (up-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","7p15.3",7,23502974,"IGF2BP3","- ",null,null,10643,null,null,"rs12534093-A","rs12534093",0,12534093,"intron",0,0.22,2e-14,13.698970004336,null,0.03,"[NR] unit decrease","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V4 (up-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","1p36.13",1,17306675,"MFAP2","- ",null,null,4237,null,null,"rs2284746-C","rs2284746",0,2284746,"intron",0,0.48,4e-29,28.397940008672,null,0.04,"[NR] unit decrease","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V4 (up-regulated)","10/17/2010",20864672,"Waterworth DM","09/23/2010","Arterioscler Thromb Vasc Biol","http://www.ncbi.nlm.nih.gov/pubmed/20864672","Genetic variants influencing circulating lipid levels and risk of coronary artery disease.","LDL cholesterol"," (up-regulated) to 17,243 white European descent individuals"," (up-regulated) to 37,774 white European descent individuals,  (up-regulated) to 9,665 Indian Asian individuals","6p22.3",6,16197194,"MYLIP,GMPR",null,346116,2766,null,24.93,41.62,"rs2142672-C","rs2142672",0,2142672,null,1,0.74,2e-08,7.69897000433601,null,0.01,"[0.007-0.015] unit increase","Affymetrix, Illumina & Perlegen [2,155,369] (imputed)","N"]
["V4 (up-regulated)","09/21/2010",20694011,"Ferreira RC","08/08/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20694011","Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.","Immunoglobulin A ","430 Icelandic and Swedish cases, 1,090 Icelandic and Swedish controls","256 Spanish cases, 322 Spanish controls, 86 Finnish cases, 564 Finnish controls","2q24.2",2,163124051,"IFIH1","- ",null,null,64135,null,null,"rs1990760-?","rs1990760",0,1990760,"missense",0,0.61,7e-10,9.15490195998574,null,1.49,"[1.32-1.69] ","Illumina [2,057,134] (imputed)","N"]
["V4 (up-regulated)","09/13/2010",20694148,"Zabaneh D","08/04/2010","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/20694148","A genome-wide association study of the metabolic syndrome in Indian Asian men.","Metabolic syndrome","2,554 Indian Asian men","2,240 Indian Asian men","18q21.32",18,57751014,"PMAIP1",null,728115,400652,null,66.21,65.76,"rs12957347-?","rs12957347",0,12957347,null,1,0.36,7e-06,5.15490195998574,"(Metabolic syndrome)","NR","NR","Illumina [308,011]","N"]
["V4 (up-regulated)","07/30/2010",20558539,"Kestenbaum B","06/17/2010","J Am Soc Nephrol","http://www.ncbi.nlm.nih.gov/pubmed/20558539","Common genetic variants associate with serum phosphorus concentration.","Phosphorus levels","16,264 European ancestry individuals","5,444 individuals","12p13.32",12,4606168,"FGF6,RAD51AP1,FGF23","- ",null,null,57102,null,null,"rs2970818-A","rs2970818",0,2970818,"intron",0,0.09,4e-09,8.39794000867203,null,0.05,"[NR] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V4 (up-regulated)","06/22/2010",20526339,"Quan C","06/06/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20526339","Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC.","Vitiligo","1,117 Chinese Han cases, 1,429 Chinese Han controls","5,910 Chinese Han cases, 9,916 Chinese Han controls, 713 Chinese Uygur cases, 824 Chinese Uygur controls","6p21.33",6,31837066,"HLA-C,HLA-B","- ",null,null,80736,null,null,"rs11966200-A","rs11966200",0,11966200,"intron",0,0.06,1e-48,47.9999999999999,null,1.9,"[1.74-2.07] ","Illumina [493,909]","N"]
["V4 (up-regulated)","06/14/2010",20512145,"Bei JX","05/30/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20512145","A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.","Nasopharyngeal carcinoma","1,583 Southern Chinese descent cases, 972 Southern Chinese descent controls, 922 Singapore Chinese controls","3,507 Southern Chinese descent cases, 3,063 Southern Chinese descent controls, 284 Southern Chinese family trios","6p21.33",6,31263751,"HLA-B,HLA-C",null,387122,3106,null,6.81,57.9,"rs2894207-?","rs2894207",0,2894207,null,1,0.82,3e-33,32.5228787452803,null,1.64,"[1.52-1.75] ","Illumina [464,328]","N"]
["V4 (up-regulated)","05/10/2010",20205591,"Pelak K","04/15/2010","J Infect Dis","http://www.ncbi.nlm.nih.gov/pubmed/20205591","Host determinants of HIV-1 control in African Americans.","HIV-1 control","515 African American cases","NR","6p21.33",6,31322559,"HLA-B","- ",null,null,3106,null,null,"rs2523608-?","rs2523608",0,2523608,"intron",0,0.37,3e-06,5.52287874528033,null,"NR","NR","Illumina [1,212,217]","N"]
["V4 (up-regulated)","05/05/2010",20383146,"Kottgen A","04/11/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20383146","New loci associated with kidney function and chronic kidney disease.","Chronic kidney disease"," (up-regulated) to 67,093 European ancestry individuals"," (up-regulated) to 22,982 European ancestry individuals","11q13.1",11,65506822,"RNASEH2C,KAT5,OVOL1",null,390211,91056,null,11.34,34.55,"rs4014195-G","rs4014195",0,4014195,null,1,0.35,1e-07,7,"(eGFRcrea)",0.01,"[0.006-0.010] ml/min/1.73 m2 decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V4 (up-regulated)","04/14/2010",20339536,"Barber MJ","03/22/2010","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/20339536","Genome-wide association of lipid-lowering response to statins in combined study populations.","Response to statin therapy","3,928 Caucasian individuals","NR","2q24.1",2,156925286,"NR4A2, GPD2, LOC728038",null,100873266,4929,null,755.35,255.66,"rs16839962-T","rs16839962",0,16839962,null,1,0.13,9e-06,5.04575749056067,"(HDL, sum)","NR","NR","Illumina [~2.5 million](imputed)","N"]
["V4 (up-regulated)","04/02/2010",20228799,"McGovern DP","03/14/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20228799","Genome-wide association identifies multiple ulcerative colitis susceptibility loci.","Ulcerative colitis","2,693 European descent cases, 6,791 European descent controls","2,009 European descent cases, 1,580 European descent controls","9p24.1",9,4981602,"JAK2",null,406894,3717,null,131.23,3.64,"rs10758669-C","rs10758669",0,10758669,null,1,"NR",1e-06,5.99999999999999,null,1.22,"[NR] ","Affymetrix [266,047]","N"]
["V4 (up-regulated)","08/30/2010",20045101,"Ferreira MA","12/31/2009","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/20045101","Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control.","CD4:CD8 lymphocyte ratio","2,538 adolescent twins from 1,089 Australian families","592 siblings and 386 parents from 272 Australian families, 396 siblings from 278 UK families","6p21.33",6,31252396,"HLA-B",null,116935,387122,null,3.05,2.77,"rs2524054-A","rs2524054",0,2524054,null,1,0.32,6e-21,20.2218487496163,"(CD8)",0.31,"[0.25-0.37] SD decrease","Illumina [529,721]","N"]
["V4 (up-regulated)","08/30/2010",20045101,"Ferreira MA","12/31/2009","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/20045101","Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control.","CD4:CD8 lymphocyte ratio","2,538 adolescent twins from 1,089 Australian families","592 siblings and 386 parents from 272 Australian families, 396 siblings from 278 UK families","6p21.33",6,31252396,"HLA-B",null,116935,387122,null,3.05,2.77,"rs2524054-A","rs2524054",0,2524054,null,1,0.32,2e-28,27.698970004336,"(CD4:CD8)",0.37,"[0.31-0.43] SD increase","Illumina [529,721]","N"]
["V4 (up-regulated)","01/19/2010",20041166,"Fellay J","12/24/2009","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20041166?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Common genetic variation and the control of HIV-1 in humans.","HIV-1 control","2,362 Caucasian cases","NR","6p21.33",6,31431780,"HCP5, HLA-B","- ",null,null,10866,null,null,"rs2395029-?","rs2395029",0,2395029,"ncRNA",0,"NR",1e-11,11,"(progression)","NR","NR","Illumina [NR]","N"]
["V4 (up-regulated)","01/19/2010",20041166,"Fellay J","12/24/2009","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20041166?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Common genetic variation and the control of HIV-1 in humans.","HIV-1 control","2,362 Caucasian cases","NR","6p21.33",6,31431780,"HCP5, HLA-B","- ",null,null,10866,null,null,"rs2395029-G","rs2395029",0,2395029,"ncRNA",0,0.048,5e-35,34.3010299956639,"(setpoint)",5.8,"[NR] % increase","Illumina [NR]","N"]
["V4 (up-regulated)","01/19/2010",20041166,"Fellay J","12/24/2009","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20041166?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Common genetic variation and the control of HIV-1 in humans.","HIV-1 control","2,362 Caucasian cases","NR","6p21.33",6,31274380,"HLA-C",null,387122,3106,null,17.44,47.27,"rs9264942-C","rs9264942",0,9264942,null,1,0.412,6e-32,31.2218487496163,"(setpoint)",5.3,"[NR] % increase","Illumina [NR]","N"]
["V4 (up-regulated)","01/19/2010",20041166,"Fellay J","12/24/2009","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20041166?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Common genetic variation and the control of HIV-1 in humans.","HIV-1 control","2,362 Caucasian cases","NR","6p21.33",6,31274380,"HLA-C",null,387122,3106,null,17.44,47.27,"rs9264942-?","rs9264942",0,9264942,null,1,"NR",6e-12,11.2218487496163,"(progression)","NR","NR","Illumina [NR]","N"]
["V4 (up-regulated)","12/14/2009",19915573,"Asano K","11/15/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19915573?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=3","A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.","Ulcerative colitis","376 Japanese cases, 934 Japanese controls","376 Japanese cases, 1,097 Japanese controls","9p24.1",9,5213687,"JAK2, INSL6, INSL4",null,11172,3641,null,28.07,17.73,"rs10975003-C","rs10975003",0,10975003,null,1,0.19,1e-06,5.99999999999999,null,1.34,"[1.18-1.51] ","Illumina [513,923]","N"]
["V4 (up-regulated)","10/30/2009",19820697,"Soranzo N","10/11/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19820697?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.","Hematological parameters","4,627 European individuals","9,316 European individuals","20q11.21",null,null,"BAK1","- ",{"$nulls":5},"rs210135-A","rs210135",{"$nulls":4},"NR",4e-10,9.39794000867203,"(PLT)",5.44,"[3.74-7.14] 10^9/l increase","Affymetrix and Illumina [~2.11 million] (imputed)","N"]
["V4 (up-regulated)","10/16/2009",19801982,"Rivadeneira F","10/04/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19801982?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.","Bone mineral density (spine)","19,195 European individuals","NR","2p16.2",2,54684557,"SPTBN1","- ",null,null,6711,null,null,"rs11898505-A","rs11898505",0,11898505,"intron",0,0.34,2e-08,7.69897000433601,null,0.07,"[0.05-0.09] s.d. increase","Affymetrix & Illumina [2,543,686](imputed)","N"]
["V4 (up-regulated)","07/10/2009",19571808,"Stefansson H","07/01/2009","Nature","http://www.ncbi.nlm.nih.gov/pubmed/19571808","Common variants conferring risk of schizophrenia.","Schizophrenia","2,663 European ancestry cases, 13,498 European ancestry controls","10,282 European ancestry cases, 21,093 European ancestry controls","2p16.1",2,58222928,"VRK2",null,647016,7444,null,946.46,50.85,"rs2312147-C","rs2312147",0,2312147,null,1,"NR",3e-07,6.52287874528033,null,1.09,"[NR] ","Illumina [314,868]","N"]
["V4 (up-regulated)","07/24/2009",19581569,"Treutlein J","07/01/2009","Arch Gen Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/19581569","Genome-wide association study of alcohol dependence.","Alcohol dependence","476 European ancestry cases, 1,358 European ancestry controls","1,024 European ancestry cases, 996 European ancestry controls","5q15",5,96111371,"CAST, ERAP1","- ",null,null,51752,null,null,"rs13160562-G","rs13160562",0,13160562,"intron",0,0.68,7e-06,5.15490195998574,null,1.27,"[1.14-1.41] ","Illumina [524,396]","N"]
["V4 (up-regulated)","06/29/2009",19525953,"De Jager PL","06/14/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19525953?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.","Multiple sclerosis","2,624 cases, 7,220 controls","2,215 cases, 2,116 controls","6p22.1",6,29705659,"HLA-B","- ",null,null,285830,null,null,"rs2523393-A","rs2523393",0,2523393,"intron",0,0.59,1e-17,17,null,1.28,"[1.18-1.39] ","Affymetrix & Illumina [~2.56 million] (imputed)","N"]
["V4 (up-regulated)","06/15/2009",19483685,"Daly AK","05/31/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19483685?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin.","Drug-induced liver injury (flucloxacillin)","58 cases, 282 controls","NR","6p21.33",6,31431780,"HCP5, HLA-B","- ",null,null,10866,null,null,"rs2395029-?","rs2395029",0,2395029,"ncRNA",0,0.05,9e-33,32.0457574905606,null,45,"[19.4-105] ","Illumina [866,399]","N"]
["V4 (up-regulated)","06/14/2009",19483681,"Rapley EA","05/31/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19483681?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","A genome-wide association study of testicular germ cell tumor.","Testicular germ cell tumor","730 cases, 1,435 controls","571 cases, 1,806 controls","6p21.31",6,33542538,"BAK1","- ",null,null,578,null,null,"rs210138-G","rs210138",0,210138,"intron",0,0.2,1e-13,13,null,1.5,"[1.28-1.75] ","Illumina [307,666]","N"]
["V4 (up-regulated)","06/01/2009",19430480,"Barrett JC","05/10/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19430480?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.","Type 1 diabetes","7,514 cases, 9,045 controls","4,267 cases, 4,670 controls, 4,342 trios","2q24.2",2,163124051,"IFIH1","- ",null,null,64135,null,null,"rs1990760-?","rs1990760",0,1990760,"missense",0,"NR",7e-09,8.15490195998574,null,"NR","NR","Affymetrix & Illumina [841,622] (imputed)","N"]
["V4 (up-regulated)","05/07/2009",19412175,"Capasso M","05/03/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19412175?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Common variations in BARD1 influence susceptibility to high-risk neuroblastoma.","Neuroblastoma (high-risk)","397 cases, 2,043 controls","189 cases, 1,178 controls","2q35",2,215672546,"BARD1","- ",null,null,580,null,null,"rs6435862-G","rs6435862",0,6435862,"intron",0,0.29,9e-18,17.0457574905606,null,1.68,"[1.49-1.90] ","Illumina [462,866]","N"]
["V4 (up-regulated)","04/22/2009",19343178,"Soranzo N","04/03/2009","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/19343178?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.","Height","12,611 individuals","7,187 individuals","6p21.33",6,31354560,"HLA-B",null,267015,100507436,null,4.3,13,"rs13437082-?","rs13437082",0,13437082,null,1,0.13,5e-08,7.30102999566398,null,0.07,"[0.04-0.10] s.d. decrease","Illumina [229,216]","N"]
["V4 (up-regulated)","03/31/2009",19287384,"Kilpivaara O","03/15/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19287384?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms.","Myeloproliferative neoplasms","324 cases, 2,999 controls","NR","9p24.1",9,5070831,"JAK2","- ",null,null,3717,null,null,"rs10974944-?","rs10974944",0,10974944,"intron",0,"NR",4e-20,19.397940008672,null,3.1,"[2.40-4.00] ","Affymetrix [62,775]","N"]
["V4 (up-regulated)","02/06/2009",19169254,"Nair RP","01/25/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19169254?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.","Psoriasis","1,359 cases, 1,400 controls","5,048 cases, 5,041 controls","6p21.33",6,31252925,"HLA-C",null,116935,387122,null,3.58,2.24,"rs12191877-T","rs12191877",0,12191877,null,1,0.15,1e-100,100,null,2.64,"[NR] ","Perlegen [~2.5 million] (imputed)","N"]
["V4 (up-regulated)","01/16/2009",19115949,"Limou S","01/01/2009","J Infect Dis","http://www.ncbi.nlm.nih.gov/pubmed/19115949?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).","AIDS progression","275 HIV positive patients, 1,438 controls","626 patients","6p21.33",6,31274555,"HLA-C",null,387122,3106,null,17.61,47.09,"rs10484554-T","rs10484554",0,10484554,null,1,0.13,6e-08,7.22184874961635,null,"NR","NR","Illumina [291,119]","N"]
["V4 (up-regulated)","01/16/2009",19115949,"Limou S","01/01/2009","J Infect Dis","http://www.ncbi.nlm.nih.gov/pubmed/19115949?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).","AIDS progression","275 HIV positive patients, 1,438 controls","626 patients","6p21.33",6,31431780,"HCP5, MICB, MCCD1, BAT1, LTB, TNF","- ",null,null,10866,null,null,"rs2395029-G","rs2395029",0,2395029,"ncRNA",0,0.03,3e-19,18.5228787452803,null,3.47,"[2.39-5.04] ","Illumina [291,119]","N"]
["V4 (up-regulated)","01/14/2009",19084217,"Benyamin B","12/17/2008","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/19084217?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.","Iron status biomarkers","459 twin pairs","NR","6p22.2",6,25997458,"TRIM38",{"$nulls":6},"rs12216125-?","rs12216125",0,12216125,null,1,"NR",4e-06,5.39794000867203,"(transferrin saturation)","NR","NR","Illumina [315,887]","N"]
["V4 (up-regulated)","01/16/2009",19079262,"Styrkarsdottir U","12/14/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19079262?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","New sequence variants associated with bone mineral density.","Bone mineral density (spine)","6,865 individuals","8,510 individuals","2p16.2",2,54684557,"SPTBN1","- ",null,null,6711,null,null,"rs11898505-G","rs11898505",0,11898505,"intron",0,0.68,4e-06,5.39794000867203,null,0.07,"[0.04-0.10] s.d. decrease","Illumina [305,051]","N"]
["V4 (up-regulated)","01/16/2009",19010793,"Baranzini SE","11/14/2008","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19010793?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.","Multiple sclerosis","978 cases,883 controls","NR","3q23",3,140540718,"SLC25A36",null,287015,646685,null,120.73,80.32,"rs908821-?","rs908821",0,908821,null,1,0.71,3e-06,5.52287874528033,null,1.37,"[NR] ","Illumina[551,642]","N"]
["V4 (up-regulated)","01/16/2009",19010793,"Baranzini SE","11/14/2008","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19010793?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.","Multiple sclerosis (severity)","794 cases, 883 controls","NR","7p22.1",7,7268431,"C1GALT1","- ",null,null,56913,null,null,"rs10259085-?","rs10259085",0,10259085,"intron",0,0.46,4e-06,5.39794000867203,null,"NR","NR","Illumina[551,642]","N"]
["V4 (up-regulated)","11/25/2008",18758461,"Di Bernardo MC","08/31/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18758461?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.","Chronic lymphocytic leukemia","505 cases, 1,438 controls","1,024 cases,1,677 controls","19q13.32",19,47207654,"PRKD2,STRN4","- ",null,null,25865,null,null,"rs11083846-A","rs11083846",0,11083846,null,0,0.22,4e-09,8.39794000867203,null,1.35,"[1.22-1.49] ","Illumina[345,665]","N"]
["V4 (up-regulated)","11/25/2008",18758461,"Di Bernardo MC","08/31/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18758461?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.","Chronic lymphocytic leukemia","505 cases, 1,438 controls","1,024 cases,1,677 controls","2q37.1",2,231091223,"SP140, SP110","- ",null,null,"3431;11262",null,null,"rs13397985-G","rs13397985",0,13397985,"nearGene-5;intron",0,0.19,6e-10,9.22184874961635,null,1.41,"[1.26-1.57] ","Illumina[345,665]","N"]
["V4 (up-regulated)","11/25/2008",18587394,"Barrett JC","06/29/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18587394?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.","Crohn's disease","3,230 cases4,829 controls","1,339 trios, 2,325 cases, 1,809 controls","9p24.1",9,4981602,"JAK2",null,406894,3717,null,131.23,3.64,"rs10758669-C","rs10758669",0,10758669,null,1,0.35,3e-09,8.52287874528033,null,1.12,"[NR] ","Affymetrix and Illumina[635,547](imputed)","N"]
["V4 (up-regulated)","11/25/2008",18464913,"Melzer D","05/09/2008","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/18464913?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association study identifies protein quantitative trait loci (pQTLs).","Protein quantitative trait loci","1,200 individuals","NR","6p21.33",6,31271716,"HLA-C",null,387122,3106,null,14.78,49.93,"rs9461688-?","rs9461688",0,9461688,null,1,0.31,4e-06,5.39794000867203,"(IL18)","NR","NR","Illumina[496,032]","N"]
["V4 (up-regulated)","11/25/2008",18445777,"Styrkarsdottir U","04/29/2008","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/18445777?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Multiple genetic loci for bone mineral density and fractures.","Bone mineral density (spine)","5,861 individuals","7,925 individuals","2p16.2",2,54684557,"SPTBN1","- ",null,null,6711,null,null,"rs11898505-G","rs11898505",0,11898505,"intron",0,0.67,8e-07,6.09691001300805,null,0.08,"[0.05-0.11] s.d. decrease","Illumina[301,019]","N"]
["V4 (up-regulated)","11/25/2008",18391951,"Gudbjartsson DF","04/06/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18391951?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Many sequence variants affecting diversity of adult human height.","Height","30,968 individuals","8,541 individuals","20q11.22",20,33909784,"UQCC, GDF5, CEP250, EIF6, MMP24","- ",null,null,55245,null,null,"rs6088792-T","rs6088792",0,6088792,"intron",0,0.26,8e-07,6.09691001300805,null,4.7,"[2.74-6.66] % s.d. taller","Illumina and Affymetrix[ (up-regulated) to 304,226]","N"]
["V4 (up-regulated)","11/25/2008",18369459,"Liu Y","04/04/2008","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/18369459?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.","Psoriasis","218 cases,519 controls","1,153 cases,1,217 controls","6p21.33",6,31431780,"HLA-C","- ",null,null,10866,null,null,"rs2395029-C","rs2395029",0,2395029,"ncRNA",0,0.03,2e-26,25.698970004336,null,4.1,"[3.10-5.30] ","Illumina[305,983]","N"]
["V4 (up-regulated)","11/25/2008",18369459,"Liu Y","04/04/2008","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/18369459?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.","Psoriasis","218 cases,519 controls","1,153 cases,1,217 controls","6p21.33",6,31274555,"HLA-C",null,387122,3106,null,17.61,47.09,"rs10484554-T","rs10484554",0,10484554,null,1,0.15,2e-39,38.698970004336,null,2.8,"[2.40-3.30] ","Illumina[305,983]","N"]
["V4 (up-regulated)","11/25/2008",18364390,"Capon F","03/25/2008","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/18364390?ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene.","Psoriasis","318 cases,288 controls","2,361 cases,1,927 controls","6p21.33",6,31312326,"HLA-C",null,387122,3106,null,55.39,9.32,"rs3134792-?","rs3134792",0,3134792,null,1,"NR",1e-09,8.99999999999999,null,"NR","NR","Illumina[~408,000] (pooled)","N"]
["V4 (up-regulated)","11/25/2008",17903292,"Hwang SJ","09/19/2007","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/17903292?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study.","Thyroid stimulating hormone","810-1,010 individualsdepending on measure(Framingham)","NR","7p15.3",7,22109459,"RAPGEF5",null,55536,9771,null,123.92,48.45,"rs10499559-?","rs10499559",0,10499559,null,1,"NR",8e-06,5.09691001300805,null,"NR","NR","Affymetrix[70,897]","N"]
["V4 (up-regulated)","11/25/2008",17554260,"Todd JA","06/06/2007","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/17554260?ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.","Type 1 diabetes","1,963 cases,2,938 controls","2997 trios, 4,000 cases, 5,000 controls","2q24.2",2,163124051,"IFIH1","- ",null,null,64135,null,null,"rs1990760-A","rs1990760",0,1990760,"missense",0,0.6,2e-11,10.698970004336,null,1.18,"[1.11-1.23] ","see WTCCC","N"]
["V4 (down-regulated)","06/18/2013",23561647,"van Setten J","03/13/2013","Atherosclerosis","http://www.ncbi.nlm.nih.gov/pubmed/23561647","Genome-wide association study of coronary and aortic calcification implicates risk loci for coronary artery disease and myocardial infarction.","Coronary artery calcification","2,620 European ancestry males",null,"15q25.1",15,79089111,"ADAMTS7","- ",null,null,11173,null,null,"rs3825807-A","rs3825807",0,3825807,"missense",0,0.57,7e-06,5.15490195998574,null,0.36,"[0.21-0.52] unit increase","Illumina [2.5 Million] (Imputed)","N"]
["V4 (down-regulated)","05/31/2013",23449627,"Cousminer DL","02/27/2013","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23449627","Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.","Pubertal anthropometrics","7,161 European ancestry males, 6,879 European ancestry females","5,133 European ancestry males, 4,577 European ancestry females","9q21.12",9,73157416,"TRPM3","- ",null,null,80036,null,null,"rs10780944-G","rs10780944",0,10780944,"intron",0,0.19,8e-07,6.09691001300805,"(Single Height-males)",0.09,"[0.053-0.127] unit increase","Illumina & Affymetrix [~2.5 million] (imputed)","N"]
["V4 (down-regulated)","06/06/2013",23453885,"Smoller JW","02/27/2013","Lancet","http://www.ncbi.nlm.nih.gov/pubmed/23453885","Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.","Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined)","6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls","NR","10q21.2",10,62279124,"ANK3","- ",null,null,288,null,null,"rs10994397-?","rs10994397",0,10994397,"intron",0,0.065,7e-09,8.15490195998574,null,"NR","NR","NR [1,252,901] (imputed)","N"]
["V4 (down-regulated)","06/06/2013",23453885,"Smoller JW","02/27/2013","Lancet","http://www.ncbi.nlm.nih.gov/pubmed/23453885","Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.","Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined)","6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls","NR","10q21.2",10,62222107,"ANK3","- ",null,null,288,null,null,"rs10994359-C","rs10994359",0,10994359,"intron",0,"NR",3e-09,8.52287874528033,"(5 degree of freedom test)",1.08,"[1.03-1.13] ","NR [1,252,901] (imputed)","N"]
["V4 (down-regulated)","06/28/2013",23446634,"Chen Z","02/26/2013","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23446634","Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.","Red blood cell traits"," (up-regulated) to 16,485 African American individuals","9,692 African American individuals, 21,020 European ancestry individuals, 14,088 Japanese ancestry individuals","16p13.3",16,310380,"ITFG3, LUCL7, NPRL3, POLR3K, RPL2B, MPG, NME4, DECR, RHOT2, LMF1,WDR90","- ",null,null,83986,null,null,"rs13335629-A","rs13335629",0,13335629,"intron",0,0.134,4e-22,21.397940008672,"(MCV, AA)",0.65,"[0.52-0.78] fL decrease","Affymetrix & Illumina [NR]","N"]
["V4 (down-regulated)","05/21/2013",23437003,"Paternoster L","02/21/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23437003","Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure.","Bone mineral density"," (up-regulated) to 5,878 European ancestry individuals"," (up-regulated) to 1,052 European ancestry individuals","6q25.1",6,151895456,"C6orf97, ESR1","- ",null,null,80129,null,null,"rs6909279-G","rs6909279",0,6909279,"intron",0,0.4,1e-09,8.99999999999999,"(Cortical vBMD)",0.09,"[0.070-0.110] unit decrease","Illumina [2,401,124] (Imputed)","N"]
["V4 (down-regulated)","05/01/2013",23364394,"Lee JY","01/31/2013","J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23364394 ","A genome-wide association study of a coronary artery disease risk variant.","Coronary heart disease","2,123 Korean ancestry cases; 3,591 Korean ancestry controls","3,052 Japanese ancestry cases; 4,976 Japanese ancestry controls","12q24.12",12,112168009,"ACAD10, ALDH2, C12orf51, RPL6-PTPN11","- ",null,null,80724,null,null,"rs11066015-A","rs11066015",0,11066015,"intron",0,"NR",5e-11,10.3010299956639,null,1.41,"[1.27-1.56] ","Affymetrix [521,786] ","N"]
["V4 (down-regulated)","05/02/2013",23364009,"Yang X","01/30/2013","Am J Clin Nutr","http://www.ncbi.nlm.nih.gov/pubmed/23364009 ","Common variants at 12q24 are associated with drinking behavior in Han Chinese.","Drinking behavior","1,420 Han Chinese cases, 3,590 Han Chinese controls","4,896 Han Chinese cases, 13,293 Han Chinese controls","12q24.13",12,112817783,"C12orf51, CCDC63, MYL2, ALDH2","- ",null,null,283450,null,null,"rs11066280-T","rs11066280",0,11066280,"intron",0,0.84,3e-215,214.52287874528,null,3.33,"[3.23-3.45] ","Affymetrix [~2.2 Million] (Imputed)","N"]
["V4 (down-regulated)","04/04/2013",23319000,"Luykx JJ","01/15/2013","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23319000 ","Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.","Metabolite levels (5-HIAA)"," (up-regulated) to 398 European individuals","NR","16q23.1",16,78335044,"WWOX","- ",null,null,51741,null,null,"rs78867184-G","rs78867184",0,78867184,"intron",0,"NR",9e-06,5.04575749056067,null,0.21,"unit increase","Illumina [5,767,231] (Imputed)","N"]
["V4 (down-regulated)","03/28/2013",23291589,"Lu Y","01/06/2013","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23291589 ","Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.","Corneal structure","13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals","NR","9q34.3",9,137440528,"RXRA, COL5A1",null,6256,1289,null,108.1,93.12,"rs1536482-A","rs1536482",0,1536482,null,1,0.34,3e-22,21.5228787452803,null,0.12,"[0.1-0.14] unit decrease","Illumina & Affymetrix [~1 Million] (Imputed)","N"]
["V4 (down-regulated)","02/21/2013",23273568,"Yang W","12/27/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23273568","Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic l (up-regulated)us erythematosus in Asians.","Systemic l (up-regulated)us erythematosus","1,656 Han Chinese cases, 3,394 Han Chinese controls","3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls","12p13.2",12,12773521,"CREBL2","- ",null,null,1389,null,null,"rs12822507-A","rs12822507",0,12822507,null,0,0.57,2e-08,7.69897000433601,null,1.16,null,"Illumina [2,100,739] (imputed)","N"]
["V4 (down-regulated)","02/21/2013",23267103,"Desch KC","12/24/2012","Proc Natl Acad Sci U S A","http://www.ncbi.nlm.nih.gov/pubmed/23267103 ","Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association.","Coagulation factor levels","3,250 European ancestry individuals,  (up-regulated) to 212 individuals","NR","9q34.2",9,136135552,"ABO, LOC653163, ADAMTS13, OBP2B, OBP2A, C9orf96, LOC286310, SURF6, SURF5","- ",null,null,28,null,null,"rs8176704-A","rs8176704",0,8176704,"intron",0,"NR",4e-34,33.397940008672,"(Conditioned on rs687289)",0.34,"[NR] lU/dL decrease","Illumina [723,716]","N"]
["V4 (down-regulated)","02/21/2013",23267103,"Desch KC","12/24/2012","Proc Natl Acad Sci U S A","http://www.ncbi.nlm.nih.gov/pubmed/23267103 ","Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association.","Coagulation factor levels","3,250 European ancestry individuals,  (up-regulated) to 212 individuals","NR","9q34.2",9,136137106,"ABO, LOC653163, ADAMTS13, OBP2B, OBP2A, C9orf96, LOC286310, SURF6, SURF5","- ",null,null,28,null,null,"rs687289-T","rs687289",0,687289,"intron",0,0.751,1e-128,128,null,0.33,"[0.30-0.36] lU/dL increase","Illumina [723,716]","N"]
["V4 (down-regulated)","03/05/2013",23263487,"Jia WH","12/23/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263487","Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer.","Colorectal cancer","2,098 East Asian ancestry cases, 5,749 East Asian ancestry controls","5,358 East Asian ancestry cases, 5,922 East Asian ancestry controls, 26,060 European ancestry individuals","20p12.3",20,7812350,"HAO1, PLCB1","- ",null,null,171472,null,null,"rs2423279-C","rs2423279",0,2423279,null,0,0.302,2e-07,6.69897000433601,"(East Asian)",1.14,"[1.08-1.19] ","Illumina & Affymetrix (1,636,380) imputed","N"]
["V4 (down-regulated)","03/05/2013",23263487,"Jia WH","12/23/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263487","Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer.","Colorectal cancer","2,098 East Asian ancestry cases, 5,749 East Asian ancestry controls","5,358 East Asian ancestry cases, 5,922 East Asian ancestry controls, 26,060 European ancestry individuals","20p12.3",20,7812350,"HAO1, PLCB1","- ",null,null,171472,null,null,"rs2423279-C","rs2423279",0,2423279,null,0,0.252,7e-09,8.15490195998574,null,1.1,"[1.06-1.14] ","Illumina & Affymetrix (1,636,380) imputed","N"]
["V4 (down-regulated)","03/15/2013",23263486,"Kottgen A","12/23/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263486","Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.","Urate levels","49,825 European ancestry men, 60,522 European ancestry women"," (up-regulated) to 32,813 European ancestry individuals","2q23.1",2,148716428,"ORC4L, ACVR2A","- ",null,null,5000,null,null,"rs2307394-T","rs2307394",0,2307394,"missense",0,0.68,2e-08,7.69897000433601,null,0.03,"[0.019-0.039] mg/dl decrease","Affymetrix, Illumina, Perlegen [2,450,547] (imputed)","N"]
["V4 (down-regulated)","03/15/2013",23263486,"Kottgen A","12/23/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263486","Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.","Urate levels","49,825 European ancestry men, 60,522 European ancestry women"," (up-regulated) to 32,813 European ancestry individuals","11q13.1",11,65560620,"OVOL1, LTBP3","- ",null,null,5017,null,null,"rs642803-T","rs642803",0,642803,"intron",0,0.46,3e-13,12.5228787452803,null,0.04,"[0.026-0.045] mg/dl decrease","Affymetrix, Illumina, Perlegen [2,450,547] (imputed)","N"]
["V4 (down-regulated)","03/15/2013",23263486,"Kottgen A","12/23/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263486","Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.","Urate levels","49,825 European ancestry men, 60,522 European ancestry women"," (up-regulated) to 32,813 European ancestry individuals","12q13.3",12,57844049,"INHBC, INHBE","- ",null,null,3626,null,null,"rs3741414-T","rs3741414",0,3741414,"UTR-3",0,0.24,2e-25,24.698970004336,null,0.07,"[0.058-0.085] mg/dl decrease","Affymetrix, Illumina, Perlegen [2,450,547] (imputed)","N"]
["V4 (down-regulated)","02/27/2013",23284291,"Hancock DB","12/20/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23284291 ","Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.","Pulmonary function (interaction)","50,047 European ancestry individuals","NR","1p36.13",1,17591679,"PADI3","- ",null,null,51702,null,null,"rs3003429-T ","rs3003429   ",0,3003429,"intron",0,"NR",4e-07,6.39794000867203,"(FEV1, Pack-years)","NR","NR","NR [~2.5 Million] (imputed)","N"]
["V4 (down-regulated)","02/27/2013",23284291,"Hancock DB","12/20/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23284291 ","Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.","Pulmonary function (interaction)","50,047 European ancestry individuals","NR","11q13.4",11,73312252,"FAM168A ,  PLEKHB",null,100874482,58473,null,20.65,44.97,"rs10751226-T ","rs10751226   ",0,10751226,null,1,"NR",3e-07,6.52287874528033,"(FEV1/FVC, Pack-years)","NR","NR","NR [~2.5 Million] (imputed)","N"]
["V4 (down-regulated)","02/27/2013",23284291,"Hancock DB","12/20/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23284291 ","Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.","Pulmonary function (interaction)","50,047 European ancestry individuals","NR","16q23.1",16,78188496,"WWOX","- ",null,null,51741,null,null,"rs8056446-A ","rs8056446   ",0,8056446,"intron",0,"NR",8e-08,7.09691001300805,"(FEV1, Pack-years ","NR","NR","NR [~2.5 Million] (imputed)","N"]
["V4 (down-regulated)","02/27/2013",23284291,"Hancock DB","12/20/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23284291 ","Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.","Pulmonary function (interaction)","50,047 European ancestry individuals","NR","16q23.1",16,78187903,"WWOX","- ",null,null,51741,null,null,"rs12716850-A ","rs12716850   ",0,12716850,"intron",0,"NR",1e-07,7,"(FEV1, Ever-smoking)","NR","NR","NR [~2.5 Million] (imputed)","N"]
["V4 (down-regulated)","02/27/2013",23284291,"Hancock DB","12/20/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23284291 ","Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.","Pulmonary function (interaction)","50,047 European ancestry individuals","NR","11q13.4",11,73312252,"FAM168A ,  PLEKHB",null,100874482,58473,null,20.65,44.97,"rs10751226-T ","rs10751226   ",0,10751226,null,1,"NR",4e-07,6.39794000867203,"(FEV1/FVC, Ever-smoking)","NR","NR","NR [~2.5 Million] (imputed)","N"]
["V4 (down-regulated)","03/15/2013",23263863,"Li J","12/20/2012","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263863","GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.","Hematology traits","7,943 African American children, 6,234 European ancestry children","NR","11p15.4",11,5303063,"HBE1, HBB, HBD, HBBP1, HBG1",null,3046,403265,null,11.69,9.63,"rs2213169-T","rs2213169",0,2213169,null,1,0.1362,5e-11,10.3010299956639,"(AA, HCT)",0.45,"[0.31-0.58] unit decrease","Illumina [544,917]","N"]
["V4 (down-regulated)","03/15/2013",23263863,"Li J","12/20/2012","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263863","GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.","Mean corpuscular hemoglobin concentration","7,943 African American children, 6,234 European ancestry children","NR","11p15.4",11,5303063,"HBE1, HBB, HBD, HBBP1, HBG1",null,3046,403265,null,11.69,9.63,"rs2213169-T","rs2213169",0,2213169,null,1,0.1362,1e-13,13,"(AA)",0.22,"[0.16-0.28] unit increase","Illumina [544,917]","N"]
["V4 (down-regulated)","02/27/2013",23247143,"Yu B","12/16/2012","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/23247143","Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.","Cardiac Troponin-T levels","9,491 European ancestry individuals,  (up-regulated) to 2,053 African American individuals","NR","2q11.2",2,96841793,"STARD7",null,1844,56910,null,30.61,8.8,"rs11886999-T","rs11886999",0,11886999,null,1,"NR",8e-06,5.09691001300805,"(Continous Variable)",0.04,"[0.02-0.06] ug/L increase","Affymetrix and Illumina [~2.5 Million] (imputed)","N"]
["V4 (down-regulated)","12/16/2012",23001997,"Hou S","12/06/2012","Arthritis Rheum","http://www.ncbi.nlm.nih.gov/pubmed/23001997","Identification of a susceptibility locus in STAT4 for Beh&#x000e7;et's disease in Han Chinese in a genome-wide association study.","Behcet's disease","147 Han Chinese cases, 951 Han Chinese controls","554 Han Chinese cases, 1,159 Han Chinese controls","2q14.2",2,122018763,"TFCP2L1","- ",null,null,29842,null,null,"rs17006292-?","rs17006292",0,17006292,"intron",0,0.925,5e-09,8.30102999566398,null,4.17,"[2.50-5.00] ","Affyemtrix [661,736]","N"]
["V4 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","6q25.1",6,152080832,"ESR1","- ",null,null,2099,null,null,"rs60945108-A","rs60945108",0,60945108,"intron",0,0.009,3e-06,5.52287874528033,"(Light activity )",0.03,"[NR]  min/d increase","Illumina [899,892]","N"]
["V4 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","10q24.2",10,100583915,"HPSE2","- ",null,null,60495,null,null,"rs2801405-G","rs2801405",0,2801405,"intron",0,0.33,9e-06,5.04575749056067,"(Urinary free norepinephrine )",0.03,"[NR]  nmol/d increase","Illumina [899,892]","N"]
["V4 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","9p24.2",9,2696555,"KCNV2, KIAA0020",null,7436,169522,null,42.07,20.97,"rs930811-G","rs930811",0,930811,null,1,0.406,1e-06,5.99999999999999,"(Birth weight )",0.04,"[NR]  kg increase","Illumina [899,892]","N"]
["V4 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","16p12.1",16,27214984,"JMJD5","- ",null,null,79831,null,null,"rs16976587-A","rs16976587",0,16976587,"intron",0,0.006,9e-06,5.04575749056067,"(Folate )",0.02,"[NR]  nmol/L increase","Illumina [899,892]","N"]
["V4 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","16q23.1",16,74978618,"WDR59","- ",null,null,79726,null,null,"rs2042415-A","rs2042415",0,2042415,"intron",0,0.146,8e-06,5.09691001300805,"(Weight change )",0.03,"[NR]  kg/y increase","Illumina [899,892]","N"]
["V4 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","16q23.1",16,74978618,"WDR59","- ",null,null,79726,null,null,"rs2042415-A","rs2042415",0,2042415,"intron",0,0.146,3e-06,5.52287874528033,"(Energy storage )",0.04,"[NR]  kcal/d increase","Illumina [899,892]","N"]
["V4 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","16q23.1",16,74978618,"WDR59","- ",null,null,79726,null,null,"rs2042415-A","rs2042415",0,2042415,"intron",0,0.146,5e-06,5.30102999566398,"(Fat mass change )",0.04,"[NR]  kg/y increase","Illumina [899,892]","N"]
["V4 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","16q23.1",16,74978618,"WDR59","- ",null,null,79726,null,null,"rs2042415-A","rs2042415",0,2042415,"intron",0,0.146,8e-06,5.09691001300805,"(Fat mass deposition )",0.04,"[NR]  kcal/d increase","Illumina [899,892]","N"]
["V4 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","18q12.3",18,39937509,"PIK3C3","- ",null,null,284260,null,null,"rs9304270-A","rs9304270",0,9304270,"intron",0,0.122,2e-06,5.69897000433601,"(C-peptide )",0.03,"[NR]  ng/mL increase","Illumina [899,892]","N"]
["V4 (down-regulated)","01/30/2013",23160099,"Justice CM","11/18/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23160099","A genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9.","Sagittal craniosynostosis","130 European ancestry trios","172 cases, 548 controls","7p14.3",7,33256039,"BBS9","- ",null,null,27241,null,null,"rs10262453-A","rs10262453",0,10262453,"intron",0,0.69,6e-20,19.2218487496163,null,4.17,"[3.13-5.88] ","Illumina [915,307]","N"]
["V4 (down-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Crohn's disease"," (up-regulated) to 12,924 European ancestry cases,  (up-regulated) to 21,442 European ancestry controls "," (up-regulated) to 25,683 European ancestry cases,  (up-regulated) to 17,015 European ancestry controls ","1p12",1,120451190,"ADAM30",null,11085,4853,null,12.04,2.99,"rs3897478-T","rs3897478",0,3897478,null,1,0.891,2e-11,10.698970004336,null,1.16,"[1.101-1.224] ","Affyemtrix & Illumina [1.23 million] (imputed)","N"]
["V4 (down-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","6q21",6,111848191,"TRAF3IP2,FYN,REV3L","- ",null,null,643749,null,null,"rs3851228-T","rs3851228",0,3851228,"intron",0,0.073,1e-13,13,null,1.15,"[1.089-1.219] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V4 (down-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","3p21.31",3,49721532,"MST1,PFKFB4,MST1R,UCN2,GPX1,IP6K2,BSN,IP6K1,USP4","- ",null,null,4485,null,null,"rs3197999-A","rs3197999",0,3197999,"missense",0,0.296,1e-47,47,null,1.18,"[1.144-1.216] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V4 (down-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","17q21.2",17,40527544,"STAT3,STAT5B,STAT5A","- ",null,null,6774,null,null,"rs12942547-A","rs12942547",0,12942547,"intron",0,0.58,6e-22,21.2218487496163,null,1.1,"[1.072-1.136] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V4 (down-regulated)","01/09/2013",23092984,"Goes FS","10/23/2012","Transl Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23092984","Genome-wide association of mood-incongruent psychotic bipolar disorder.","Bipolar disorder (mood-incongruent)","2,196 cases, 8,148 controls","NR","3p21.1",3,52718280,"PBRM1, GNL3","- ",null,null,"26354;55193",null,null,"rs10865974-?","rs10865974",0,10865974,"nearGene-5;intron",0,"NR",2e-06,5.69897000433601,null,1.19,"[NR] ","Affymetrix & Illumina [NR] (~2.5 Million)","N"]
["V4 (down-regulated)","01/16/2013",23064961,"Shaffer JR","10/11/2012","J Dent Res","http://www.ncbi.nlm.nih.gov/pubmed/23064961","GWAS of dental caries patterns in the permanent dentition.","Dental caries","920 European ancestry individuals","NR","17q11.1",17,25567080,"WSB1","- ",null,null,100506418,null,null,"rs12602978-?","rs12602978",0,12602978,"intron",0,"NR",7e-07,6.15490195998574,"(DMFS5mand)","NR","NR","Illumina [518,997]","N"]
["V4 (down-regulated)","01/16/2013",23064961,"Shaffer JR","10/11/2012","J Dent Res","http://www.ncbi.nlm.nih.gov/pubmed/23064961","GWAS of dental caries patterns in the permanent dentition.","Dental caries","920 European ancestry individuals","NR","4q22.1",4,89064581,"ABCG2,PKD2, SPP1, MEPE, IBSP, DMP1, DSPP","- ",null,null,9429,null,null,"rs3114018-?","rs3114018",0,3114018,"intron",0,"NR",7e-08,7.15490195998574,"(DMFS5mand,DMFS5)","NR","NR","Illumina [518,997]","N"]
["V4 (down-regulated)","12/21/2012",23043469,"Menzel S","10/09/2012","Br J Haematol","http://www.ncbi.nlm.nih.gov/pubmed/23043469","HbA2 levels in normal adults are influenced by two distinct genetic mechanisms.","HbA2 levels","2,322 European ancestry individuals","1,716 European ancestry individuals","11p15.4",11,5225447,"HBB",null,283111,3043,null,3.52,21.25,"rs7950726-A","rs7950726",0,7950726,null,1,0.12,1e-11,11,null,"NR","NR","Illumina [531,038]","N"]
["V4 (down-regulated)","01/09/2013",23041239,"Traylor M","10/05/2012","Lancet Neurol","http://www.ncbi.nlm.nih.gov/pubmed/23041239","Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.","Stroke (ischemic)","12,389 European ancestry cases, 62,004 European ancestry controls","1,322 Pakistani ancestry cases, 1,143 Pakistani ancestry controls, 12,025 European ancestry cases, 27,940 European ancestry controls","12q24.12",12,112211833,"ALDH2","- ",null,null,217,null,null,"rs2238151-T","rs2238151",0,2238151,"intron",0,0.66,1e-06,5.99999999999999,"(FS)",1.13,"[1.08-1.19] ","Affymetrix & Illumina [NR] (imputed)","N"]
["V4 (down-regulated)","12/06/2012",23006423,"Niu N M D Ph D","09/24/2012","BMC Cancer","http://www.ncbi.nlm.nih.gov/pubmed/23006423 ","Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.","Response to taxane treatment (docetaxel)","96 African American lymphoblastoid cell lines, 96 European ancestry lymphoblastoid cell lines, 96 Han Chinese lymphoblastoid cell lines","NR","17q21.33",17,48289070,"COL1A1 ",null,1277,100131823,null,10.07,24.14,"rs2586502-?  ","rs2586502 ",0,2586502,null,1,"NR",1e-06,5.99999999999999,null,"NR","NR","Affymetrix & Illumina [~1.3 Million]","N"]
["V4 (down-regulated)","01/15/2013",23225573,"Buck D","09/08/2012","Ann Neurol","http://www.ncbi.nlm.nih.gov/pubmed/23225573","Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis.","IgG levels","229 European ancestry multiple sclerosis cases","409 European ancestry multiple sclerosis cases","14q32.33",14,106232585,"IGHG3, IGHG1, IGHG2","- ",null,null,3502,null,null,"rs10136766-A","rs10136766",0,10136766,null,0,0.27,8e-16,15.096910013008,null,0.23,"[NR] unit increase","Illumina [526,014]","N"]
["V4 (down-regulated)","11/05/2012",22952603,"Hart AB","08/28/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/22952603","Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).","Response to amphetamines","1 American Indian ancestry individual, 18 African American/Afro-Caribbean ancestry individuals, 10 East Asian and South Asian ancestry individuals, 325 European ancestry individuals, 17 Latin American ancestry individuals, 6 other ancestry individuals, 4 individuals","NR","16q23.1",16,79073421,"WWOX","- ",null,null,51741,null,null,"rs17713676-?","rs17713676",0,17713676,"intron",0,"NR",8e-06,5.09691001300805,"(SF3)","NR","NR","Affymetrix [5,476,100] (imputed)","N"]
["V4 (down-regulated)","11/04/2012",22895189,"Timmann C","08/15/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/22895189","Genome-wide association study indicates two novel resistance loci for severe malaria.","Malaria","1,325 African ancestry, 828 African ancestry controls","2,229 African ancestry cases, 3,526 African ancestry controls","11p15.4",11,5518156,"HBB",null,390066,50613,null,7.18,10.37,"rs372091-C","rs372091",0,372091,null,1,0.972,6e-14,13.2218487496163,null,2.17,"[NR] ","Affymetrix [4,205,739] (imputed)","N"]
["V4 (down-regulated)","09/18/2012",22814818,"Hoehn R","07/20/2012","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/22814818","Population-based meta-analysis in Caucasians confirms association with COL5A1 and ZNF469 but not COL8A2 with central corneal thickness.","Central corneal thickness","3,931 European ancestry individuals","1,418 European ancestry individuals","9q34.3",9,137440212,"RXRA, COL5A1",null,6256,1289,null,107.78,93.44,"rs3132306-T","rs3132306",0,3132306,null,1,0.66,3e-10,9.52287874528033,null,0.15,"[0.11-0.19] SD increase","Affymetrix [NR] (imputed)","N"]
["V4 (down-regulated)","09/18/2012",22797727,"Okada Y","07/15/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22797727","Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.","Renal function-related traits (sCR)","42,257 Japanese, Chinese, Malay, and Indian ancestry individuals","19,662 Japanese, Chinese, and Korean ancestry individuals","12q24.12",12,112241766,"ALDH2","- ",null,null,217,null,null,"rs671-A","rs671",0,671,"missense",0,0.27,3e-10,9.52287874528033,null,0,"[0.0031-0.0059] mg/dl increase","Affymetrix & Illumina [2,353,587] (imputed)","N"]
["V4 (down-regulated)","09/14/2012",22780124,"Lind PA","07/11/2012","Addict Biol","http://www.ncbi.nlm.nih.gov/pubmed/22780124","Genome-wide association study of a quantitative disordered gambling trait.","Gambling","1,312 twins from 894 families","NR","12q24.33",12,130630935,"Intergenic, FZD10, FLJ31485",null,121256,440119,null,242.72,5.2,"rs11060736-T","rs11060736",0,11060736,null,1,0.941,4e-06,5.39794000867203,null,0.29,"[0.16-0.41] unit decrease","Illumina [2,373,249] (imputed)","N"]
["V4 (down-regulated)","08/20/2012",22747683,"Eriksson N","06/30/2012","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/22747683","Genetic variants associated with breast size also influence breast cancer risk.","Breast size","16,175 European ancestry women","NR","6q25.1",6,151957714,"ESR1, C6orf97",null,80129,2099,null,15.39,53.92,"rs12173570-T","rs12173570",0,12173570,null,1,0.101,6e-11,10.2218487496163,null,0.17,"[0.12-0.22] c (up-regulated) size increase","Illumina [7,422,970] (imputed)","N"]
["V4 (down-regulated)","08/15/2012",22703881,"Tang W","06/14/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/22703881","Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.","Activated partial thromboplastin time","9,240 European ancestry individuals","2611 European ancestry individuals","9q34.2",9,136137065,"ABO, LOC653163, SURF2, SURF4, ADAMTS13, C9orf7","- ",null,null,28,null,null,"rs687621-A","rs687621",0,687621,"intron",0,"NR",9e-100,99.0457574905606,null,0.82,"[0.73-0.90] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V4 (down-regulated)","07/19/2012",22664479,"Han JY","06/05/2012","Pharmacogenomics J","http://www.ncbi.nlm.nih.gov/pubmed/22664479","A genome-wide association study for irinotecan-related severe toxicities in patients with advanced non-small-cell lung cancer.","Response to irinotecan in non-small-cell lung cancer","101 non-small-cell lung cancer cases","146 non-small-cell lung cancer cases","20p12.3",20,8277943,"PLCB1","- ",null,null,23236,null,null,"rs2745761-C","rs2745761",0,2745761,"intron",0,0.072,6e-06,5.22184874961635,"(G3D)",4.8,"[2.30-10.0] ","Affyemtrix [312,230]","N"]
["V4 (down-regulated)","08/14/2012",22832960,"Service SK","05/15/2012","Transl Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22832960","A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.","Temperament"," (up-regulated) to 12,433 individuals","NR","15q13.1",15,29239817,"APBA2","- ",null,null,321,null,null,"rs17680945-A","rs17680945",0,17680945,"intron",0,0.02,2e-06,5.69897000433601,"(Harm avoidance)",0.92,"unit increase","Affymetrix & Illumina [1,252,222] (imputed)","N"]
["V4 (down-regulated)","08/15/2012",22581228,"Manning AK","05/13/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22581228","A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.","Fasting glucose-related traits (interaction with BMI)"," (up-regulated) to 58,074 European ancestry individuals"," (up-regulated) tp 38,422 European ancestry individuals","15q22.2",15,62396942,"VPS13C",null,145741,388125,null,33.83,58.8,"rs7173964-?","rs7173964",0,7173964,null,1,"NR",6e-12,11.2218487496163,null,"NR","NR","Affymetrix & Illumina [~2.4 million] (imputed)","N"]
["V4 (down-regulated)","08/17/2012",22589738,"Fox CS","05/10/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22589738","Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.","Visceral adipose tissue adjusted for BMI","5,560 European ancestry women and 4,997 European ancestry men","NR","22q12.3",22,33566587,"LARGE",null,7078,100616295,null,307.56,265.98,"rs4821132-C","rs4821132",0,4821132,null,1,0.56,6e-06,5.22184874961635,"(women)","NR","NR","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V4 (down-regulated)","08/17/2012",22589738,"Fox CS","05/10/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22589738","Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.","Visceral adipose tissue/subcutaneous adipose tissue ratio","5,560 European ancestry women and 4,997 European ancestry men","NR","22q12.3",22,33561746,"LARGE",null,7078,100616295,null,302.72,270.82,"rs743793-T","rs743793",0,743793,null,1,0.54,6e-07,6.22184874961635,"(women)","NR","NR","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V4 (down-regulated)","08/17/2012",22589738,"Fox CS","05/10/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22589738","Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.","Visceral fat","5,560 European ancestry women and 4,997 European ancestry men","NR","22q12.3",22,33746526,"LARGE","- ",null,null,9215,null,null,"rs2267193-C","rs2267193",0,2267193,"intron",0,0.28,8e-06,5.09691001300805,"(overall)","NR","NR","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V4 (down-regulated)","07/21/2012",22566498,"Turner ST","05/07/2012","Hypertension","http://www.ncbi.nlm.nih.gov/pubmed/22566498","Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.","Response to angiotensin II receptor blocker therapy","198 European ancestry hypertensive individuals, 193 African American hypertensive individuals","NR","4q24",4,101806532,"EMCN",null,51705,5530,null,367.28,138.06,"rs13107740-G","rs13107740",0,13107740,null,1,"NR",5e-06,5.30102999566398,"(AA)",1.51,"[0.78-2.24] unit decrease","Affymetrix [~2.3 million] (imputed)","N"]
["V4 (down-regulated)","07/09/2012",22561531,"Wan YI","05/05/2012","Thorax","http://www.ncbi.nlm.nih.gov/pubmed/22561531","Genome-wide association study to identify genetic determinants of severe asthma.","Asthma","933 European ancestry cases, 3,346 European ancestry controls","231 European ancestry cases, 1,345 European ancestry controls","9p21.1",9,32433526,"ACO1","- ",null,null,48,null,null,"rs10970976-?","rs10970976",0,10970976,"intron",0,"NR",4e-06,5.39794000867203,null,1.28,"[1.16-1.43] ","Illumina [6,103,628] (Imputed)","N"]
["V4 (down-regulated)","06/19/2012",22491018,"Wang J","04/10/2012","Pharmacogenomics J","http://www.ncbi.nlm.nih.gov/pubmed/22491018","Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.","Response to tocilizumab in rheumatoid arthritis","1,157 European and other ancestry rheumatoid arthritis cases","526 European and other ancestry rheumatoid arthritis cases","3p25.3",3,10877611,"SLC6A11","- ",null,null,6538,null,null,"rs1809529-?","rs1809529",0,1809529,"intron",0,0.34,3e-07,6.52287874528033,"(CHAQ, RF-)",0.28,"[NR] unit increase","Illumina [534,053]","N"]
["V4 (down-regulated)","04/25/2012",22449649,"Loo SK","02/28/2012","J Am Acad Child Adolesc Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22449649","Genome-wide association study of intelligence: additive effects of novel brain expressed genes.","Intelligence","656 individuals of European ancestry from ADHD families","NR","9q34.2[rs34312136]; 9q34.2[rs35079168]",null,null,"RXRA","- ",{"$nulls":5},"4-SNP haplotype","rs34312136, rs35079168, rs4501664, rs11102986",{"$nulls":4},"NR",8e-08,null,"(Schizophrenia, Cognitive ability)","NR","NR","Illumina [795,637]","N"]
["V4 (down-regulated)","03/17/2012",22383897,"Long J","02/23/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22383897","Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer.","Breast cancer","2,918 Chinese ancestry cases, 2,324 Chinese ancestry controls"," (up-regulated) to 6,838 Chinese ancestry cases,  (up-regulated) to 6,888 Chinese ancestry controls,  (up-regulated) to 1,297 Han Chinese cases,  (up-regulated) to 1,585 Han Chinese controls,  (up-regulated) to 1,066 Taiwan Chinese cases,  (up-regulated) to 1,065 Taiwan Chinese controls,  (up-regulated) to 5,038 Korean ancestry cases,  (up-regulated) to 6,869 Korean ancestry controls,  (up-regulated) to 1,934 Japanese ancestry cases,  (up-regulated) to 1,875 Japanese ancestry controls","6q25.1",6,152295613,"ESR1","- ",null,null,2099,null,null,"rs9383951-G","rs9383951",0,9383951,"intron",0,0.9,2e-06,5.69897000433601,null,1.14,"[1.08-1.19] ","Affymetrix [690,947]","N"]
["V4 (down-regulated)","02/23/2012",22286173,"Low SK","01/27/2012","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/22286173","Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA.","Intracranial aneurysm","1,383 Japanese ancestry cases, 5,484 Japanese ancestry controls","1,048 Japanese ancestry cases, 7,212 Japanese ancestry controls","12q24.12",12,112241766,"ALDH2","- ",null,null,217,null,null,"rs671-C","rs671",0,671,"missense",0,0.746,3e-06,5.52287874528033,null,1.24,"[1.148-1.338] ","Illumina [565,149]","N"]
["V4 (down-regulated)","02/22/2012",22291609,"Naitza S","01/26/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22291609","A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.","Inflammatory biomarkers","4,694 European ancestry individuals","1,392 European ancestry individuals","11p15.4",11,5306509,"HBB",null,3046,403265,null,15.14,6.19,"rs4910742-G","rs4910742",0,4910742,null,1,0.066,2e-09,8.69897000433601,"(ESR)","NR","NR","Affymetrix [~1.9 million] (imputed)","N"]
["V4 (down-regulated)","03/10/2012",22228203,"Aslibekyan S","01/05/2012","Pharmacogenet Genomics","http://www.ncbi.nlm.nih.gov/pubmed/22228203","A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network.","Inflammatory biomarkers","1,092 European ancestry individuals","NR","7q32.1",7,128993756,"AHCYL2","- ",null,null,23382,null,null,"rs11979476-?","rs11979476",0,11979476,"intron",0,"NR",2e-06,5.69897000433601,"(Tumor necrosis factor-a)","NR","NR","Affymetrix [2,543,887](imputed)","N"]
["V4 (down-regulated)","01/10/2012",22171074,"Tan A","12/30/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/22171074","A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population.","Triglycerides","1,999 Chinese ancestry individuals","1,496 Chinese ancestry individuals.","12q24.12",12,112241766,"ALDH2","- ",null,null,217,null,null,"rs671-?","rs671",0,671,"missense",0,"NR",2e-06,5.69897000433601,null,"NR","NR","Illumina [1,940,243] (imputed)","N"]
["V4 (down-regulated)","01/27/2012",22182935,"Chen DT","12/20/2011","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22182935","Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.","Bipolar disorder","5,568 European ancestry cases, 7,187 European ancestry controls, 1,000 Taiwanese cases, 1,000 Taiwanese controls","1,115 European ancestry cases, 2,728 European ancestry controls","10q21.2",10,62185494,"ANK3","- ",null,null,288,null,null,"rs4948418-T","rs4948418",0,4948418,"intron",0,"NR",4e-10,9.39794000867203,null,"NR","NR","Affymetrix & Illumina [748,555]","N"]
["V4 (down-regulated)","01/18/2012",22158537,"Cho YS","12/11/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22158537","Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.","Type 2 diabetes","4,026 Chinese ancestry cases, 1,042 Korean ancestry cases, 794 Malaysian ancestry cases, 931 Japanese ancestry cases, 159 Filipino ancestry cases, 4,654 Chinese ancestry controls, 2,943 Korean ancestry controls, 1,240 Malaysian ancestry controls, 1,404 Japanese ancestry controls, 1,624 Filipino ancestry controls.","9,723 Japanese ancestry cases, 1,815 Korean ancestry cases, 6,589 Chinese ancestry cases, 8,974 Japanese ancestry controls, 2,066 Korean ancestry controls, Chinese ancestry controls.","16q23.2",16,79406918,"WWOX",null,645957,4094,null,546.94,220.83,"rs17797882-T","rs17797882",0,17797882,null,1,0.32,9e-07,6.04575749056067,null,1.08,"[1.05�.12] ","Affymetrix & Illumina [2,626,356](imputed)","N"]
["V4 (down-regulated)","01/18/2012",22158540,"Wu C","12/11/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22158540","Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.","Pancreatic cancer","981 Chinese ancestry cases, 1,991 Chinese ancestry contorls.","2,603 Chinese ancestry cases, 2,877 Chinese ancestry controls.","9p24.2",9,4426631,"SLC1A1",null,169792,6505,null,126.6,63.8,"rs10974531-A","rs10974531",0,10974531,null,1,"NR",5e-06,5.30102999566398,null,1.24,"[1.13-1.35] ","Affymetrix [666,141]","N"]
["V4 (down-regulated)","12/02/2011",22041458,"Clark SL","11/01/2011","Psychol Med","http://www.ncbi.nlm.nih.gov/pubmed/22041458","Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.","Response to antidepressant treatment","1,439 non-psychotic major depressive disorder cases","NR","6q25.3",6,158041283,"ZDHHC14","- ",null,null,79683,null,null,"rs2163287-A","rs2163287",0,2163287,"intron",0,0.02,3e-06,5.52287874528033,"(Citalopram+Buspirone, Dizziness)","NR","NR","Affymetrix [421,789]","N"]
["V4 (down-regulated)","11/19/2011",22005931,"Kamboh MI","10/18/2011","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22005931","Genome-wide association analysis of age-at-onset in Alzheimer's disease.","Alzheimer's disease (age of onset)","2,222 cases","NR","9p24.2",9,2742771,"KCNV2, VLDLR",null,169522,9933,null,12.73,61.38,"rs2034764-?","rs2034764",0,2034764,null,1,"NR",4e-06,5.39794000867203,null,"NR","NR","Illumina [2,543,888] (imputed)","N"]
["V4 (down-regulated)","11/18/2011",22001757,"Chambers JC","10/16/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22001757","Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.","Liver enzyme levels (alkaline phosphatase)"," (up-regulated) to 52,350 European ancestry individuals,  (up-regulated) to 8,739 Indian Asian individuals","NR","9q31.1",9,104223233,"ALDOB, C9orf125",null,229,84302,null,25.17,14.38,"rs10819937-C","rs10819937",0,10819937,null,1,0.17,1e-09,8.99999999999999,null,2.5,"[1.40-3.60] % increase","Affymetrix, Illumina, and Perlegen [~2.6 million] (imputed)","N"]
["V4 (down-regulated)","11/16/2011",22003152,"Grallert H","10/14/2011","Eur Heart J","http://www.ncbi.nlm.nih.gov/pubmed/22003152","Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies.","Lipoprotein-associated phospholipase A2 activity and mass","13,664 European ancestry individuals","NR","1p13.3",1,109817192,"CELSR2","- ",null,null,1952,null,null,"rs7528419-A","rs7528419",0,7528419,"UTR-3",0,0.79,1e-17,17,"(Activity concentrations)",0.04,"[0.027-0.043] unit increase","Affymetrix & Illumina [2,661,766] (imputed)","N"]
["V4 (down-regulated)","11/03/2011",21971053,"Takeuchi F","10/05/2011","Eur J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/21971053","Genome-wide association study of coronary artery disease in the Japanese.","Coronary heart disease","806 Japanese ancestry cases, 1,337 Japanese ancestry controls","3,593 Japanese ancestry cases, 6,335 Japanese ancestry controls","12q24.12",12,112241766,"ALDH2","- ",null,null,217,null,null,"rs671-A","rs671",0,671,"missense",0,0.23,2e-34,33.698970004336,null,1.43,"[1.35-1.51] ","Illumina [451,382]","N"]
["V4 (down-regulated)","10/18/2011",21946350,"Soler Artigas M","09/25/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21946350","Genome-wide association and large-scale follow  (up-regulated) identifies 16 new loci influencing lung function.","Pulmonary function","48,201 European ancestry individuals","46,411 European ancestry individuals","16q23.1",16,78188738,"WWOX","- ",null,null,51741,null,null,"rs12716852-G","rs12716852",0,12716852,"intron",0,"NR",2e-07,6.69897000433601,"(FEV1)",0.03,"[0.015-0.035] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V4 (down-regulated)","10/20/2011",21943158,"Middelberg RP","09/24/2011","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/21943158","Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.","Cardiovascular disease risk factors","11,683 individuals","NR","1p13.3",1,109817838,"CELSR2","- ",null,null,1952,null,null,"rs660240-T","rs660240",0,660240,"UTR-3",0,0.22,2e-22,21.698970004336,"(LDL)",0.17,"[0.14-0.20] mmol/l decrease","Illumina [NR] (imputed)","N"]
["V4 (down-regulated)","10/19/2011",21926972,"Sklar P","09/18/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21926972","Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.","Bipolar disorder","7,481 European ancestry cases, 9,250 European ancestry controls","4,496 European ancestry cases, 42,422 European ancestry controls","11q13.2",11,66551002,"ZDHHC24, YIF1A, TMEM151A, SYT12, SPTBN2,SLC29A2, SF3B2, RIN1, RCE1, RBM4B, RBM4, RBM14, RAB1B, PELI3, PC, PACS1, NPAS4, MRPL11, LRFN4, KLC2, GAL3ST3, DPP3, CTSF, CNIH2, CD248, CCS, CCDC87, C11orf86, C11orf80, BRMS1, BBS1, B3GNT1, ACTN3","- ",null,null,79703,null,null,"rs10896135-G","rs10896135",0,10896135,"intron",0,"NR",2e-07,6.69897000433601,null,1.12,"[NR] ","Affymetrix & Illumina [2,415,422] (imputed)","N"]
["V4 (down-regulated)","10/19/2011",21926972,"Sklar P","09/18/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21926972","Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.","Bipolar disorder","7,481 European ancestry cases, 9,250 European ancestry controls","4,496 European ancestry cases, 42,422 European ancestry controls","3p21.1",3,52835354,"WDR82, TWF2, TNNC1, TMEM110, TLR9, STAB1,SPCS1, SNORD69, SNORD19, SNORD19B, SFMBT1, SEMA3G, RFT1, PRKCD, PPM1M, PHF7, PBRM1, NT5DC2, NISCH, NEK4, MUSTN1, LOC440957, ITIH1, ITIH3, ITIH4, GNL3, GLYCTK, GLT8D1, DNAH1, BAP1, ALAS1","- ",null,null,3699,null,null,"rs736408-C","rs736408",0,736408,"intron",0,"NR",2e-06,5.69897000433601,null,1.1,"[NR] ","Affymetrix & Illumina [2,415,422] (imputed)","N"]
["V4 (down-regulated)","10/19/2011",21926972,"Sklar P","09/18/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21926972","Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.","Bipolar disorder","7,481 European ancestry cases, 9,250 European ancestry controls","4,496 European ancestry cases, 42,422 European ancestry controls","10q21.2",10,62279124,"ANK3","- ",null,null,288,null,null,"rs10994397-T","rs10994397",0,10994397,"intron",0,"NR",3e-07,6.52287874528033,null,1.22,"[NR] ","Affymetrix & Illumina [2,415,422] (imputed)","N"]
["V4 (down-regulated)","10/11/2011",21909109,"Kim YJ","09/11/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21909109","Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.","Metabolite levels","12,545 Korean ancestry individuals"," (up-regulated) to 30,395 East Asian ancestry individuals","1p13.3",1,109822166,"CELSR2, PSRC1, SORT1","- ",null,null,84722,null,null,"rs599839-G","rs599839",0,599839,"nearGene-3",0,0.06,2e-19,18.698970004336,"(LDL)",5.23,"[4.09-6.37] mg/dL decrease","Affymetrix [~2.2 million] (imputed)","N"]
["V4 (down-regulated)","09/27/2011",21873549,"Strawbridge RJ","08/26/2011","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/21873549","Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.","Proinsulin levels","10,701 European ancestry nondiabetic adults","16,378 European ancestry nondiabetic adults","15q22.2",15,62383155,"VPS13C, C2CD4A, C2CD4B",null,145741,388125,null,20.04,72.58,"rs4502156-T","rs4502156",0,4502156,null,1,0.58,4e-20,19.397940008672,null,"NR","NR","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V4 (down-regulated)","09/27/2011",21901158,"Irvin MR","08/25/2011","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/21901158","Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study.","Insulin resistance/response","1,040 non-diabetic individuals","NR","9q21.33",9,89573083,"GAS1","- ",null,null,100506834,null,null,"rs9792548-C","rs9792548",0,9792548,"intron",0,0.15,4e-06,5.39794000867203,"(HOMA-IR)",12,"[7.00 - 16.00] % decrease","Affymetrix [872,243]","N"]
["V4 (down-regulated)","09/21/2011",21841780,"Chu X","08/14/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21841780","A genome-wide association study identifies two new risk loci for Graves' disease.","Graves' disease","1,468 Chinese ancestry cases, 1,490 Chinese ancestry controls","3,994 Chinese ancestry cases, 3,510 Chinese ancestry controls","4p14",4,40303633,"RHOH, CHRNA9",null,399,55584,null,57.35,33.71,"rs6832151-G","rs6832151",0,6832151,null,1,0.35,1e-13,13,null,1.24,"[1.17-1.31] ","Illumina [486,049]","N"]
["V4 (down-regulated)","10/24/2012",21833088,"Sawcer S","08/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21833088","Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.","Multiple sclerosis","9,772 European ancestry cases, 16,849 European ancestry controls","4,218 European ancestry cases, 7,296 European ancestry controls","6q23.3",6,135739355,"AHI1","- ",null,null,54806,null,null,"rs11154801-A","rs11154801",0,11154801,"intron",0,"NR",1e-13,13,null,1.13,"[1.11-1.15] ","Illumina [465,434]","N"]
["V4 (down-regulated)","09/03/2011",21771265,"Yosifova A","07/19/2011","Genes Brain Behav","http://www.ncbi.nlm.nih.gov/pubmed/21771265","Genome-wide association study on bipolar disorder in the Bulgarian population.","Bipolar disorder","188 Bulgarian cases, 376 Bulgarian controls","122 Bulgarian cases, 328 Bulgarian controls","19q13.2",19,42521108,"GRIK5","- ",null,null,2901,null,null,"rs8099939-T","rs8099939",0,8099939,"intron",0,0.39,2e-06,5.69897000433601,null,1.95,"[1.43-2.67] ","Illumina [497,732]","N"]
["V4 (down-regulated)","08/12/2011",21757650,"Debette S","07/14/2011","Circ Res","http://www.ncbi.nlm.nih.gov/pubmed/21757650","Identification of cis- and trans-acting genetic variants explaining  (up-regulated) to half the variation in circulating vascular endothelial growth factor levels.","Vascular endothelial growth factor levels","3,527 European ancestry individuals","1,727 European ancestry individuals","9p24.2",9,2691186,"KCNV2, VLDLR",null,7436,169522,null,36.7,26.34,"rs10738760-A","rs10738760",0,10738760,null,1,0.49,1e-39,38.9999999999999,null,"NR","NR","Affymetrix [2,540,233] (imputed)","N"]
["V4 (down-regulated)","07/30/2011",21743057,"Schumacher FR","07/08/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21743057","Genome-wide association study identifies new prostate cancer susceptibility loci.","Prostate cancer","2,782 European ancestry cases, 4,458 European ancestry controls","8,217 European ancestry cases, 6,732 European ancestry controls","2q37.3",2,238443226,"MLPH","- ",null,null,79083,null,null,"rs2292884-G","rs2292884",0,2292884,"missense",0,0.25,4e-08,7.39794000867203,null,1.14,"[1.09-1.19] ","Illumina [571,243]","N"]
["V4 (down-regulated)","07/21/2011",21738478,"Okada Y","06/30/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21738478","Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.","White blood cell types","8,794 Japanese ancestry individuals","5,998 Japanese ancestry individuals","3q21.3",3,128316435,"GATA2",null,23434,6184,null,21.51,22.38,"rs4328821-A","rs4328821",0,4328821,null,1,0.66,5e-40,39.3010299956639,"(basophil count)",0.16,"[0.14-0.18] unit increase","Illumina [2,178,645] (imputed)","N"]
["V4 (down-regulated)","07/21/2011",21738478,"Okada Y","06/30/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21738478","Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.","White blood cell types","8,794 Japanese ancestry individuals","5,998 Japanese ancestry individuals","3q21.3",3,128316435,"GATA2",null,23434,6184,null,21.51,22.38,"rs4328821-A","rs4328821",0,4328821,null,1,0.66,3e-17,16.5228787452803,"(eosinophil count)",0.1,"[0.08-0.12] unit increase","Illumina [2,178,645] (imputed)","N"]
["V4 (down-regulated)","07/14/2011",21685187,"Siedlinski M","06/16/2011","Thorax","http://www.ncbi.nlm.nih.gov/pubmed/21685187","Genome-wide association study of smoking behaviours in patients with COPD.","Chronic obstructive pulmonary disease","3,441 Caucasian ever-smokers with COPD","NR","2p21",2,47022543,"SOCS5",null,9655,90411,null,32.62,106.47,"rs76351433-A","rs76351433",0,76351433,null,1,0.96,2e-07,6.69897000433601,"(Current CPD)",1.45,"[NR] ","Illumina [~6.3 million] (imputed)","N"]
["V4 (down-regulated)","07/20/2011",21658281,"Aouizerat BE","06/10/2011","BMC Cardiovasc Disord","http://www.ncbi.nlm.nih.gov/pubmed/21658281","GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.","Sudden cardiac arrest","89 European ancestry cases, 520 European ancestry controls","NR","6q25.1",6,152285687,"ESR1","- ",null,null,2099,null,null,"rs2982694-?","rs2982694",0,2982694,"intron",0,0.14,7e-10,9.15490195998574,"(Recessive)",1.43,"[1.28-1.60] ","Affymetrix [319,222]","N"]
["V4 (down-regulated)","07/13/2011",21572416,"Kato N","05/15/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21572416","Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.","Blood pressure","17,089 East Asian ancestry individuals, 2,519 Malay ancestry individuals","30,765 East Asian ancestry individuals","12q24.13",12,112817783,"RPL6, PTPN11, ALDH2","- ",null,null,283450,null,null,"rs11066280-T","rs11066280",0,11066280,"intron",0,0.75,8e-31,30.096910013008,"(Systolic)",1.56,"[1.31-1.81] mm Hg increase","Affymetrix & Illumina [1.7 million] (imputed)","N"]
["V4 (down-regulated)","07/13/2011",21572416,"Kato N","05/15/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21572416","Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.","Blood pressure","17,089 East Asian ancestry individuals, 2,519 Malay ancestry individuals","30,765 East Asian ancestry individuals","12q24.13",12,112817783,"RPL6, PTPN11, ALDH2","- ",null,null,283450,null,null,"rs11066280-T","rs11066280",0,11066280,"intron",0,0.75,1e-35,35,"(Diastolic)",1.01,"[0.85-1.17] mm Hg increase","Affymetrix & Illumina [1.7 million] (imputed)","N"]
["V4 (down-regulated)","05/27/2011",21546767,"Murea M","05/05/2011","Am J Nephrol","http://www.ncbi.nlm.nih.gov/pubmed/21546767","Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.","Dialysis-related mortality","610 African American type 2 diabetics","NR","21q21.3",21,28744356,"NCRNA00113, ADAMTS5",null,54052,100288252,null,4.06,48.32,"rs1452093-?","rs1452093",0,1452093,null,1,0.23,2e-06,5.69897000433601,null,1.59,"[1.31-1.94] ","Affymetrix [832,357]","N"]
["V4 (down-regulated)","05/27/2011",21546767,"Murea M","05/05/2011","Am J Nephrol","http://www.ncbi.nlm.nih.gov/pubmed/21546767","Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.","Dialysis-related mortality","610 African American type 2 diabetics","NR","21q21.3",21,28734997,"NCRNA00113, ADAMTS5",null,2884,54052,null,218.68,4.33,"rs9977499-?","rs9977499",0,9977499,null,1,0.24,4e-06,5.39794000867203,null,1.57,"[1.29-1.91] ","Affymetrix [832,357]","N"]
["V4 (down-regulated)","06/01/2011",21540461,"Kim DH","05/03/2011","Blood","http://www.ncbi.nlm.nih.gov/pubmed/21540461","A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia.","Chronic myeloid leukemia","201 Korean ancestry cases, 497 Korean ancestry controls","237 Korean ancestry cases, 1,000 Korean ancestry controls, 232 European ancestry cases, 576 European ancestry controls","6q25.1",6,151907748,"MTHFD1L, AKAP12, ZBTB2, RMND1, C6orf211, C6orf97, ESR1","- ",null,null,80129,null,null,"rs4869742-T","rs4869742",0,4869742,"intron",0,0.77,2e-06,5.69897000433601,null,1.67,"[1.35-2.04] ","Affymetrix [456,522]","N"]
["V4 (down-regulated)","06/01/2011",21540461,"Kim DH","05/03/2011","Blood","http://www.ncbi.nlm.nih.gov/pubmed/21540461","A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia.","Chronic myeloid leukemia","201 Korean ancestry cases, 497 Korean ancestry controls","237 Korean ancestry cases, 1,000 Korean ancestry controls, 232 European ancestry cases, 576 European ancestry controls","17q11.1",17,25541278,"WSB1, FAM27L",null,645668,729536,null,130.13,59.86,"rs4795519-C","rs4795519",0,4795519,null,1,0.48,1e-12,12,null,1.85,"[1.56-2.17] ","Affymetrix [456,522]","N"]
["V4 (down-regulated)","06/01/2011",21507922,"Ramsuran V","05/01/2011","Clin Infect Dis","http://www.ncbi.nlm.nih.gov/pubmed/21507922","Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.","Neutrophil count","115 African ancestry HIV-negative individuals","NR","2p25.1",2,8949070,"KIDINS220","- ",null,null,57498,null,null,"rs7587928-?","rs7587928",0,7587928,"intron",0,"NR",2e-07,6.69897000433601,null,"NR","NR","Illumina [874,956]","N"]
["V4 (down-regulated)","05/28/2011",21552555,"Wang K","04/28/2011","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/21552555","A genome-wide association study on obesity and obesity-related traits.","Obesity","520 European ancestry cases, 540 European ancestry controls","1,196 non-Hispanic Caucasian individuals","16q23.1",16,78952439,"WWOX","- ",null,null,51741,null,null,"rs9923451-?","rs9923451",0,9923451,"intron",0,"NR",8e-07,6.09691001300805,"(HIP)","NR","NR","Illumina [~550,000]","N"]
["V4 (down-regulated)","05/02/2011",21460842,"Cha PC","04/03/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21460842","A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids.","Uterine fibroids","1,607 Japanese ancestry cases, 1,428 Japanese ancestry controls","3,439 Japanese ancestry cases, 3,244 Japanese ancestry controls","11p15.5",11,203788,"ODF3, BET1L, RIC8A, SIRT3","- ",null,null,51272,null,null,"rs2280543-G","rs2280543",0,2280543,"UTR-3",0,0.88,4e-12,11.397940008672,null,1.39,"[1.17-1.64] ","Illumina [457,044]","N"]
["V4 (down-regulated)","04/13/2011",21441570,"Grassi MA","03/26/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21441570","Genome-wide meta-analysis for severe diabetic retinopathy.","Diabetic retinopathy ","973 European ancestry cases, 1,856 European ancestry controls","NR","1q44",1,244173872,"AKT3, ZNF238","- ",null,null,339529,null,null,"rs10927101-A","rs10927101",0,10927101,"intron",0,0.38,2e-06,5.69897000433601,null,1.33,"[NR] ","Affymetrix & Illumina [2,543,887] (imputed)","N"]
["V4 (down-regulated)","04/13/2011",21441570,"Grassi MA","03/26/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21441570","Genome-wide meta-analysis for severe diabetic retinopathy.","Diabetic retinopathy ","973 European ancestry cases, 1,856 European ancestry controls","NR","1q44",1,244176424,"AKT3, ZNF238","- ",null,null,339529,null,null,"rs476141-A","rs476141",0,476141,"intron",0,0.51,1e-07,7,null,1.37,"[NR] ","Affymetrix & Illumina [2,543,887] (imputed)","N"]
["V4 (down-regulated)","04/13/2011",21437268,"McKay JD","03/17/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21437268","A genome-wide association study of  (up-regulated)per aerodigestive tract cancers conducted within the INHANCE consortium."," (up-regulated)per aerodigestive tract cancers","2,091 European ancestry cases, 8,334 European ancestry controls","8,744 European ancestry cases, 11,982 European ancestry controls","12q24.13",12,112521448,"ALDH2","- ",null,null,80018,null,null,"rs4767364-A","rs4767364",0,4767364,"intron",0,0.29,2e-08,7.69897000433601,null,1.13,"[1.08-1.18] ","Illumina [294,620]","N"]
["V4 (down-regulated)","04/11/2011",21378990,"Schunkert H","03/06/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21378990","Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.","Coronary heart disease","22,233 European ancestry cases, 64,762 European ancestry controls","28,834 cases, 27,674 controls, 2,115 individuals.","15q25.1",15,79089111,"ADAMTS7","- ",null,null,11173,null,null,"rs3825807-A","rs3825807",0,3825807,"missense",0,0.57,1e-12,12,null,1.08,"[1.06-1.10] ","Affymetrix & Illumina {~2.3 million] (imputed)","N"]
["V4 (down-regulated)","04/11/2011",21378988,"The Coronary Artery Disease (C4D) Genetics Consortium","03/06/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21378988","A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.","Coronary heart disease","8,424 European ancestry cases, 7,268 European ancestry controls, 6,996 South Asian cases, 7,794 South Asian controls","18,049 European ancestry cases, 16,357 European ancestry controls, 3,359 South Asian cases, 2,828 South Asian controls","1p13.3",1,109818530,"CELSR2, PSRC1, SORT1","- ",null,null,1952,null,null,"rs646776-T","rs646776",0,646776,"nearGene-3",0,"NR",6e-10,9.22184874961635,null,1.14,"[1.09-1.19] ","Illumina [574,919]","N"]
["V4 (down-regulated)","04/11/2011",21378988,"The Coronary Artery Disease (C4D) Genetics Consortium","03/06/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21378988","A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.","Coronary heart disease","8,424 European ancestry cases, 7,268 European ancestry controls, 6,996 South Asian cases, 7,794 South Asian controls","18,049 European ancestry cases, 16,357 European ancestry controls, 3,359 South Asian cases, 2,828 South Asian controls","15q25.1",15,79111093,"ADAMTS7, MORF4L1",null,11173,100271444,null,7.32,44.46,"rs4380028-C","rs4380028",0,4380028,null,1,0.65,4e-09,8.39794000867203,null,1.07,"[1.05-1.10] ","Illumina [574,919]","N"]
["V4 (down-regulated)","04/07/2011",21372407,"Takeuchi F","03/01/2011","Circ J","http://www.ncbi.nlm.nih.gov/pubmed/21372407","Confirmation of ALDH2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population.","Drinking behavior","733 Japanese cases, 729 Japanese controls","2,794 Japanese ancestry drinkers, 1,521 Japanese ancestry chance drinkers, 1,351 Japanese ancestry non-drinkers","12q24.12",12,112241766,"ALDH2, BRAP","- ",null,null,217,null,null,"rs671-?","rs671",0,671,"missense",0,0.75,4e-211,210.397940008672,null,6.25,"[5.56-7.14] ","Illumina [456,827]","N"]
["V4 (down-regulated)","04/07/2011",21347282,"Lettre G","02/10/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21347282","Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.","Coronary heart disease","8,090 African American individuals","8,849 African American or African-Caribbean individuals","1p13.3",1,109817590,"CELSR2","- ",null,null,1952,null,null,"rs12740374-T","rs12740374",0,12740374,"UTR-3",0,0.25,9e-29,28.0457574905606,"(LDL-C)",0.18,"[0.15-0.21] SD decrease","Affymetrix [~2.74 million] (imputed)","N"]
["V4 (down-regulated)","03/29/2011",21297633,"Anderson CA","02/06/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21297633","Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.","Ulcerative colitis","6,687 European ancestry cases, 19,718 European ancestry controls","9,628 European ancestry cases, 12,917 European ancestry controls","3p21.31",3,49719729,"MST1, UBA7, APEH, AMIGO3, GMPPB, BSN","- ",null,null,327,null,null,"rs9822268-A","rs9822268",0,9822268,"intron",0,0.3,2e-17,16.698970004336,null,1.21,"[1.16-1.26] ","Affymetrix & Illumina [~1.1 million] (imputed)","N"]
["V4 (down-regulated)","03/28/2011",21270382,"Baik I","01/26/2011","Am J Clin Nutr","http://www.ncbi.nlm.nih.gov/pubmed/21270382","Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men.","Alcohol consumption","1,721 Korean male drinkers","1,113 Korean male drinkers","12q24.13",12,112645401,"C12orf51,ALDH2","- ",null,null,283450,null,null,"rs2074356-T","rs2074356",0,2074356,"intron",0,0.15,9e-59,58.0457574905606,null,1.06,"[0.94-1.18] unit decrease","Affymetrix [315,914]","N"]
["V4 (down-regulated)","03/04/2011",21263130,"Fletcher O","01/24/2011","J Natl Cancer Inst","http://www.ncbi.nlm.nih.gov/pubmed/21263130","Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.","Breast cancer","1,694 British cases, 2,365 British controls, 1,145 European ancestry cases, 1,142 European ancestry controls","7,317 British cases, 8,124 British controls","6q25.1",6,151939350,"ESR1","- ",null,null,80129,null,null,"rs3734805-C","rs3734805",0,3734805,"UTR-3",0,0.08,1e-07,7,null,1.19,"[1.11-1.27] ","Illumina [~296,114]","N"]
["V4 (down-regulated)","02/23/2011",21239051,"Reilly MP","01/14/2011","Lancet","http://www.ncbi.nlm.nih.gov/pubmed/21239051","Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.","Coronary heart disease","1,808 European ancestry AngCAD cases, 915 European ancestry AngCAD controls, 4,572 European ancestry AngCAD with MI cases, 2,739 European ancestry AngCAD without MI controls","10,585 European ancestry AngCAD cases, 6,468 European ancestry AngCAD controls, 1,211 European ancestry AngCAD with MI cases, 905 European ancestry AngCAD without MI controls","15q25.1",15,79080234,"ADAMTS7","- ",null,null,11173,null,null,"rs1994016-C","rs1994016",0,1994016,"intron",0,0.6,5e-13,12.3010299956639,"(AngCAD)",1.19,"[1.13-1.24] ","Affymetrix & Illumina [~2.4 million] (imputed)","N"]
["V4 (down-regulated)","01/15/2011",21151127,"Melum E","12/12/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21151127","Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.","Primary sclerosing cholangitis","332 Scandinavian cases, 262 Scandinavian controls, 383 German cases, 2,700 German controls","259 Scandinavian cases, 729 Scandinavian controls, 498 Central European cases, 554 Central European controls, 268 U.S. cases, 554 U.S. controls","3p21.31",3,49721532,"MST1","- ",null,null,4485,null,null,"rs3197999-?","rs3197999",0,3197999,"missense",0,0.28,1e-16,16,null,1.39,"[1.24-1.56] ","Affymetrix [2,466,182] (imputed)","N"]
["V4 (down-regulated)","01/14/2011",21087763,"Carrasquillo MM","12/10/2010","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/21087763","Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma.","Progranulin levels","533 non-Hispanic white controls","508 non-Hispanic white controls","1p13.3",1,109818530,"SORT1,CELSR2,PSRC1","- ",null,null,1952,null,null,"rs646776-G","rs646776",0,646776,"nearGene-3",0,0.21,2e-30,29.698970004336,null,0.18,"[0.16-0.20] ng/ml decrease","Illumina [313,504]","N"]
["V4 (down-regulated)","01/14/2011",21130836,"Luciano M","12/03/2010","Biol Psychol","http://www.ncbi.nlm.nih.gov/pubmed/21130836","Whole genome association scan for genetic polymorphisms influencing information processing speed.","Information processing speed","1,659 Caucasian individuals from 730 families, 2,374 European descent individuals","NR","17q25.1",17,72268208,"DNAI2",null,94015,64446,null,10.05,2.18,"rs7219585-A","rs7219585",0,7219585,null,1,0.13,1e-06,5.99999999999999,"(inspection time)",0.2,"[0.12-0.28] unit increase","Illumina [~610,000]","N"]
["V4 (down-regulated)","01/08/2011",21107309,"McClay JL","11/24/2010","Neuropsychopharmacology","http://www.ncbi.nlm.nih.gov/pubmed/21107309","Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.","Reasoning","738 schizophrenia cases","NR","16q23.1",16,78569957,"WWOX","- ",null,null,51741,null,null,"rs17706989-?","rs17706989",0,17706989,"intron",0,0.03,1e-06,5.99999999999999,"(olanzapine)","NR","NR","Affymetrix [492,900]","N"]
["V4 (down-regulated)","01/08/2011",21107309,"McClay JL","11/24/2010","Neuropsychopharmacology","http://www.ncbi.nlm.nih.gov/pubmed/21107309","Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.","Reasoning","738 schizophrenia cases","NR","1p36.33",1,2069681,"PRKCZ","- ",null,null,5590,null,null,"rs3753242-?","rs3753242",0,3753242,"intron",0,0.06,1e-06,5.99999999999999,"(risperidone)","NR","NR","Affymetrix [492,900]","N"]
["V4 (down-regulated)","10/19/2012",21102463,"Franke A","11/21/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21102463","Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.","Crohn's disease","6,333 European ancestry cases, 15,056 European ancestry controls","15,694 European ancestry cases, 14,026 European ancestry controls, 414 European ancestry parent-offspring trios","3p21.31",3,49721532,"MST1,GPX1,BSN","- ",null,null,4485,null,null,"rs3197999-A","rs3197999",0,3197999,"missense",0,0.297,6e-17,16.2218487496163,null,1.22,"[1.16-1.27] ","Affymetrix & Illumina [953,241] (imputed)","N"]
["V4 (down-regulated)","11/17/2010",20935629,"Heid IM","10/10/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20935629","Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.","Waist-hip ratio"," (up-regulated) to 77,167 European descent individuals"," (up-regulated) to 113,636 European descent individuals","3p21.1",3,52506426,"NISCH, STAB1","- ",null,null,11188,null,null,"rs6784615-T","rs6784615",0,6784615,"intron",0,0.94,4e-10,9.39794000867203,null,0.04,"[NR] unit increase","Affymetrix, Illumina & Perlegen [ (up-regulated) to 2,850,269](imputed)","N"]
["V4 (down-regulated)","11/15/2010",20932654,"Kerns SL","10/05/2010","Int J Radiat Oncol Biol Phys","http://www.ncbi.nlm.nih.gov/pubmed/20932654","Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.","Erectile dysfunction and prostate cancer treatment","27 African American cases, 52 African American controls","NR","2q11.2",2,97500800,"CNNM3","- ",null,null,26505,null,null,"rs9948-?","rs9948",0,9948,"UTR-3",0,0.31,6e-06,5.22184874961635,null,4.9,"[NR] ","Affymetrix [512,497]","N"]
["V4 (down-regulated)","11/23/2010",20923822,"Niu N","10/05/2010","Genome Res","http://www.ncbi.nlm.nih.gov/pubmed/20923822","Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.","Radiation response","Human lymphoblastoid cell lines from 93 African Americans, 89 Caucasian-Americans, and 95 Han Chinese Americans","NR","16q23.1",16,78631794,"WWOX","- ",null,null,51741,null,null,"rs2859631-?","rs2859631",0,2859631,"intron",0,0.07,1e-06,5.99999999999999,null,"NR","NR","Affymetrix & Illumina [1,348,798]","N"]
["V4 (down-regulated)","11/02/2012",20889312,"Wang KS","10/01/2010","Schizophr Res","http://www.ncbi.nlm.nih.gov/pubmed/20889312","A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.","Bipolar disorder and schizophrenia","651 European American bipolar cases, 1,171 European American schizophrenia cases, 2,412 European American controls","NR","1p31.1",1,80134123,"FAM69A",null,343296,646526,null,145.97,614.91,"rs7533906-?","rs7533906",0,7533906,null,1,"NR",4e-06,5.39794000867203,null,1.3,"[NR] ","Affymetrix [722,112]","N"]
["V4 (down-regulated)","10/15/2010",20884846,"Yang Q","09/30/2010","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/20884846","Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.","Urate levels","28,283 white individuals","22,054 women","12q13.3",12,57809456,"R3HDM2,INHBC",null,22864,3626,null,105.21,19.09,"rs1106766-T","rs1106766",0,1106766,null,1,0.23,2e-11,10.698970004336,"(Urate)",5.16,"[3.65-6.67] umol/l decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V4 (down-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","6q25.1",6,152110943,"ESR1","- ",null,null,2099,null,null,"rs543650-T","rs543650",0,543650,"intron",0,0.4,1e-17,17,null,0.03,"[NR] unit decrease","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V4 (down-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","16p13.3",16,792190,"NARFL","- ",null,null,64428,null,null,"rs11648796-A","rs11648796",0,11648796,"nearGene-5",0,0.74,1e-13,13,null,0.03,"[NR] unit decrease","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V4 (down-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","2p21",2,46921285,"SOCS5",null,9419,9655,null,68.4,4.81,"rs12474201-A","rs12474201",0,12474201,null,1,0.35,3e-13,12.5228787452803,null,0.03,"[NR] unit increase","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V4 (down-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","1p36.33",1,2069172,"PRKCZ","- ",null,null,5590,null,null,"rs425277-T","rs425277",0,425277,"intron",0,0.28,2e-08,7.69897000433601,null,0.02,"[NR] unit increase","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V4 (down-regulated)","10/17/2010",20864672,"Waterworth DM","09/23/2010","Arterioscler Thromb Vasc Biol","http://www.ncbi.nlm.nih.gov/pubmed/20864672","Genetic variants influencing circulating lipid levels and risk of coronary artery disease.","LDL cholesterol"," (up-regulated) to 17,243 white European descent individuals"," (up-regulated) to 37,774 white European descent individuals,  (up-regulated) to 9,665 Indian Asian individuals","1p13.3",1,109817838,"CELSR2","- ",null,null,1952,null,null,"rs660240-A","rs660240",0,660240,"UTR-3",0,0.21,1e-26,26,null,0.04,"[0.03-0.05] unit decrease","Affymetrix, Illumina & Perlegen [2,155,369] (imputed)","N"]
["V4 (down-regulated)","09/28/2010",20838585,"Smith EN","09/09/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20838585","Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study.","Cardiovascular disease risk factors","525 European ancestry individuals","2,265 Finnish individuals","11q24.1",11,121954657,"SORL1, BLID","- ",null,null,100507145,null,null,"rs7121446-G","rs7121446",0,7121446,"intron",0,0.78,3e-06,5.52287874528033,"(waist circumference)",0.15,"[0.09-0.21] % SD decrease, SNPxAGE interaction","Illumina [545,821]","N"]
["V4 (down-regulated)","07/21/2011",20834067,"Yashin AI","09/01/2010","Aging (Albany NY)","http://www.ncbi.nlm.nih.gov/pubmed/20834067","Joint influence of small-effect genetic variants on human longevity.","Longevity","1,173 individuals","NR","9q21.12",9,73784264,"TRPM3",null,80036,100271506,null,47.75,420.19,"rs4745062-?","rs4745062",0,4745062,null,1,"NR",1e-06,5.99999999999999,"(less than or equal to)","NR","NR","[~550,000]","N"]
["V4 (down-regulated)","09/17/2010",20802479,"Anttila V","08/29/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20802479","Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1.","Migraine","2,731 European cases, 10,747 European controls","3,202 European cases, 40,062 European controls","8q22.1",8,98166913,"MTDH,PGCP",null,10404,85453,null,11.19,118.8,"rs1835740-A","rs1835740",0,1835740,null,1,0.21,2e-11,10.698970004336,null,1.18,"[1.13-1.24] ","Illumina [429,912]","N"]
["V4 (down-regulated)","09/24/2010",20708005,"Chalasani N","08/10/2010","Gastroenterology","http://www.ncbi.nlm.nih.gov/pubmed/20708005","Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.","Non-alcoholic fatty liver disease histology (AST)","236 non-Hispanic Caucasian women","NR","4q32.3",4,169409958,"DDX60L,PALLD",null,91351,100506061,null,8.32,109.31,"rs2710833-A","rs2710833",0,2710833,null,1,0.17,6e-07,6.22184874961635,null,0.41,"[NR] unit increase","Illumina [324,623]","N"]
["V4 (down-regulated)","09/24/2010",20708005,"Chalasani N","08/10/2010","Gastroenterology","http://www.ncbi.nlm.nih.gov/pubmed/20708005","Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.","Non-alcoholic fatty liver disease histology (lobular)","236 non-Hispanic Caucasian women","NR","11q13.1",11,65349756,"LTBP3, EHBP1L1","- ",null,null,254102,null,null,"rs6591182-A","rs6591182",0,6591182,"missense",0,0.47,9e-07,6.04575749056067,null,0.54,"[NR] unit increase","Illumina [324,623]","N"]
["V4 (down-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","Cholesterol, total"," (up-regulated) to 100,184 European descent individuals",null,"1p13.3",1,109818306,"CELSR2,PSRC1,SORT1","- ",null,null,1952,null,null,"rs629301-G","rs629301",0,629301,"UTR-3",0,0.22,6e-131,130.221848749616,null,5.41,"[4.94-5.88] mg/dL decrease","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V4 (down-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","LDL cholesterol"," (up-regulated) to 95,454 European descent individuals",null,"1p13.3",1,109818306,"CELSR2,PSRC1,SORT1","- ",null,null,1952,null,null,"rs629301-G","rs629301",0,629301,"UTR-3",0,0.22,1e-170,170,null,5.65,"[5.24-6.06] mg/dL decrease","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V4 (down-regulated)","06/14/2010",20463881,"Liu F","05/16/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20463881","Digital quantification of human eye color highlights genetic association of three new loci.","Eye color traits","5,951 Dutch individuals","2,261 UK twins, 1,282 Australian family members","21q22.13",21,38491095,"TTC3,DSCR9","- ",null,null,7267,null,null,"rs1003719-A","rs1003719",0,1003719,"intron",0,"NR",2e-10,9.69897000433601,"(CHS1)",0.1,"[NR] % decrease","Illumina [2,543,887] (imputed)","N"]
["V4 (down-regulated)","06/02/2010",20453838,"Turnbull C","05/09/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20453838","Genome-wide association study identifies five new breast cancer susceptibility loci.","Breast cancer","3,659 UK cases, 4,897 UK controls","12,576 European cases, 12,223 European controls","6q25.1",6,151914113,"ESR1,C6orf97","- ",null,null,80129,null,null,"rs3757318-A","rs3757318",0,3757318,"intron",0,0.07,3e-06,5.52287874528033,null,1.3,"[1.17-1.46] ","Illumina [582,886]","N"]
["V4 (down-regulated)","05/05/2010",20383146,"Kottgen A","04/11/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20383146","New loci associated with kidney function and chronic kidney disease.","Chronic kidney disease"," (up-regulated) to 67,093 European ancestry individuals"," (up-regulated) to 22,982 European ancestry individuals","1q21.3",1,150951477,"ANXA9,FAM63A,PRUNE,BNIPL,LASS2,SETDB1",null,29956,8416,null,4,3.02,"rs267734-C","rs267734",0,267734,null,1,0.2,1e-12,12,"(eGFRcrea)",0.01,"[0.004-0.016] ml/min/1.73m2 increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V4 (down-regulated)","05/03/2010",20360315,"Uher R","04/01/2010","Am J Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/20360315","Genome-wide pharmacogenetics of antidepressant response in the GENDEP project.","Response to antidepressants","706 European descent individuals","NR","6q25.1",6,149329267,"UST","- ",null,null,10090,null,null,"rs2500535-A","rs2500535",0,2500535,"intron",0,0.06,9e-06,5.04575749056067,"(genotype x drug)",29.7,"[NR] % worse outcome","Illumina [539,391]","N"]
["V4 (down-regulated)","05/03/2010",20360315,"Uher R","04/01/2010","Am J Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/20360315","Genome-wide pharmacogenetics of antidepressant response in the GENDEP project.","Response to antidepressants","706 European descent individuals","NR","6q25.1",6,149329267,"UST","- ",null,null,10090,null,null,"rs2500535-A","rs2500535",0,2500535,"intron",0,0.06,4e-08,7.39794000867203,"(nortriptyline)",27,"[NR] % worse outcome","Illumina [539,391]","N"]
["V4 (down-regulated)","04/15/2010",20351715,"Liu Y","03/30/2010","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/20351715","Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.","Bipolar disorder and major depressive disorder (combined)","4,387 Caucasian bipolar cases, 6,209 Caucasian controls, 1,695 Dutch MDD cases, 1,761 Dutch controls","NR","10q21.2",10,62181128,"ANK3","- ",null,null,288,null,null,"rs10994338-A","rs10994338",0,10994338,"intron",0,"NR",5e-07,6.30102999566398,null,"NR","NR","Affymetrix & Perlegen [1,472,580] (imputed)","N"]
["V4 (down-regulated)","04/14/2010",20339536,"Barber MJ","03/22/2010","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/20339536","Genome-wide association of lipid-lowering response to statins in combined study populations.","Response to statin therapy","3,928 Caucasian individuals","NR","2q22.3",2,148478336,"ACVR2A, ORC4L, LOC647065",null,728773,100133235,null,1129.78,81.08,"rs7584099-G","rs7584099",0,7584099,null,1,0.41,5e-07,6.30102999566398,"(Triglyceride, diff)","NR","NR","Illumina [~2.5 million](imputed)","N"]
["V4 (down-regulated)","04/14/2010",20339536,"Barber MJ","03/22/2010","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/20339536","Genome-wide association of lipid-lowering response to statins in combined study populations.","Response to statin therapy","3,928 Caucasian individuals","NR","1p13.3",1,109818530,"CELSR2,PSRC1, SORT1","- ",null,null,1952,null,null,"rs646776-C","rs646776",0,646776,"nearGene-3",0,0.19,4e-06,5.39794000867203,"(chol, sum)","NR","NR","Illumina [~2.5 million](imputed)","N"]
["V4 (down-regulated)","04/02/2010",20228799,"McGovern DP","03/14/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20228799","Genome-wide association identifies multiple ulcerative colitis susceptibility loci.","Ulcerative colitis","2,693 European descent cases, 6,791 European descent controls","2,009 European descent cases, 1,580 European descent controls","3p21.31",3,49721532,"MST1","- ",null,null,4485,null,null,"rs3197999-T","rs3197999",0,3197999,"missense",0,"NR",4e-09,8.39794000867203,null,1.2,"[NR] ","Affymetrix [266,047]","N"]
["V4 (down-regulated)","03/25/2010",20185149,"Athanasiu L","02/23/2010","J Psychiatr Res","http://www.ncbi.nlm.nih.gov/pubmed/20185149","Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort.","Schizophrenia","201 Caucasian cases, 305 European controls","2,663 European cases, 13,780 European controls","10q21.2",10,62085337,"ANK3","- ",null,null,288,null,null,"rs10761482-?","rs10761482",0,10761482,"intron",0,"NR",8e-06,5.09691001300805,null,1.16,"[NR] ","Affymetrix [572,888]","N"]
["V4 (down-regulated)","11/13/2012",20125193,"Cirulli ET","02/03/2010","Eur J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/20125193","Common genetic variation and performance on standardized cognitive tests.","Cognitive performance"," (up-regulated) to 813 European ancestry individuals,  (up-regulated) to 167 East Asian ancestry individuals,  (up-regulated) to 7 Hispanic/Latin American amncestry individuals,  (up-regulated) to 74 South Asian ancestry individuals","NR","Xq28",23,148567451,"IDS","- ",null,null,3423,null,null,"rs530501-?","rs530501",0,530501,"intron",0,"NR",4e-06,5.39794000867203,"(TrailsA)","NR","NR","Illumina [ (up-regulated) to 563,855]","N"]
["V4 (down-regulated)","11/13/2012",20125193,"Cirulli ET","02/03/2010","Eur J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/20125193","Common genetic variation and performance on standardized cognitive tests.","Cognitive performance"," (up-regulated) to 813 European ancestry individuals,  (up-regulated) to 167 East Asian ancestry individuals,  (up-regulated) to 7 Hispanic/Latin American amncestry individuals,  (up-regulated) to 74 South Asian ancestry individuals","NR","20p12.3",20,8114704,"PLCB1","- ",null,null,23236,null,null,"rs6118083-?","rs6118083",0,6118083,"intron",0,"NR",7e-06,5.15490195998574,"(Colorword)","NR","NR","Illumina [ (up-regulated) to 563,855]","N"]
["V4 (down-regulated)","02/08/2010",20081856,"McMahon FJ","01/17/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20081856?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2","Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1.","Major mood disorders","6,686 European cases, 9,068 European controls","1,930 European cases, 2,747 European controls","3p21.1",3,52584787,"PBRM1","- ",null,null,55193,null,null,"rs2251219-?","rs2251219",0,2251219,"cds-synon",0,0.59,2e-09,8.69897000433601,null,1.14,"[1.09-1.18] ","Affymetrix, Illumina and Perlegen [~2.1 million] (imputed)","N"]
["V4 (down-regulated)","02/08/2010",20081857,"Saxena R","01/17/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20081857?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=3","Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.","Two-hour glucose challenge","15,234 European individuals"," (up-regulated) to 30,620 European individuals","15q22.2",15,62332980,"VPS13C","- ",null,null,54832,null,null,"rs17271305-G","rs17271305",0,17271305,"intron",0,"NR",1e-07,7,null,0.06,"[0.04-0.08 mmol/L increase","Affymetrix & Illumina [NR]","N"]
["V4 (down-regulated)","12/11/2009",19915572,"Barrett JC","11/15/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19915572?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.","Ulcerative colitis","2,361 European ancestry cases, 5,417 European ancestry controls","2,321 European ancestry cases, 4,818 European ancestry controls","3p21.31",3,49701983,"MST1","- ",null,null,8927,null,null,"rs9858542-?","rs9858542",0,9858542,"cds-synon",0,"NR",7e-09,8.15490195998574,null,"NR","NR","Affymetrix [NR]","N"]
["V4 (down-regulated)","11/03/2009",19862010,"Ganesh SK","10/11/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19862010?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.","Hemoglobin","24,167 European ancestry individuals","9,456 European ancestry individuals","20q13.2",20,51318351,"TSHZ2",null,100189481,140697,null,99.94,188.35,"rs6013509-A","rs6013509",0,6013509,null,1,"NR",1e-10,10,null,0.06,"[0.05-0.08] g/dl decrease","Affymetrix & Illumina [~2.5 million](imputed)","N"]
["V4 (down-regulated)","10/16/2009",19801982,"Rivadeneira F","10/04/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19801982?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.","Bone mineral density (hip)","19,195 European individuals","NR","6q25.1",6,152009638,"ESR1","- ",null,null,2099,null,null,"rs2941740-G","rs2941740",0,2941740,"nearGene-5",0,0.43,2e-10,9.69897000433601,null,0.07,"[0.05-0.09] s.d. increase","Affymetrix & Illumina [2,543,686](imputed)","N"]
["V4 (down-regulated)","10/16/2009",19801982,"Rivadeneira F","10/04/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19801982?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.","Bone mineral density (spine)","19,195 European individuals","NR","6q25.1",6,152090707,"ESR1","- ",null,null,2099,null,null,"rs2504063-A","rs2504063",0,2504063,"intron",0,0.4,6e-11,10.2218487496163,null,0.08,"[0.06-0.10] s.d. decrease","Affymetrix & Illumina [2,543,686](imputed)","N"]
["V4 (down-regulated)","11/08/2012",19734545,"Need AC","09/04/2009","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19734545?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.","Cognitive performance"," (up-regulated) to 1,295 individuals","NR","20p12.3",20,8836771,"PLCB1","- ",null,null,23236,null,null,"rs6056209-?","rs6056209",0,6056209,"intron",0,0.4347,2e-06,5.69897000433601,"(RVP)","NR","NR","Illumina [475,971]","N"]
["V4 (down-regulated)","11/08/2012",19734545,"Need AC","09/04/2009","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19734545?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.","Cognitive performance"," (up-regulated) to 1,295 individuals","NR","12q24.23",12,120455764,"CCDC64","- ",null,null,92558,null,null,"rs11064994-?","rs11064994",0,11064994,"intron",0,0.05521,6e-06,5.22184874961635,"(PAL6)","NR","NR","Illumina [475,971]","N"]
["V4 (down-regulated)","11/08/2012",19734545,"Need AC","09/04/2009","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19734545?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.","Cognitive performance"," (up-regulated) to 1,295 individuals","NR","11p12",11,43086094,"API5",null,100131020,399881,null,1525.56,196.96,"rs10501293-?","rs10501293",0,10501293,null,1,0.2494,5e-06,5.30102999566398,"(SWM strategy)","NR","NR","Illumina [475,971]","N"]
["V4 (down-regulated)","09/09/2009",19706858,"Shuldiner AR","08/26/2009","JAMA","http://www.ncbi.nlm.nih.gov/pubmed/19706858","Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.","Response to clopidogrel therapy","429 Amish individuals","140 European ancestry individuals, 83 African American individuals, 4 individuals","10q23.33",10,96405502,"CYP2C18, CYP2C19, CYP2C9, CYP2C8",null,3070,1562,null,43.65,37.75,"rs12777823-?","rs12777823",0,12777823,null,1,0.17,2e-13,12.698970004336,"(Amish)","NR","NR","Affymetrix [400,230]","N"]
["V4 (down-regulated)","09/09/2009",19698717,"Cui R","08/18/2009","Gastroenterology","http://www.ncbi.nlm.nih.gov/pubmed/19698717","Functional variants in ADH1B and ALDH2 co (up-regulated)led with alcohol and smoking synergistically enhance esophageal cancer risk.","Esophageal cancer","188 Japanese ancestry cases, 938 Japanese ancestry controls","699 Japanese ancestry cases, 1,482 Japanese ancestry controls","12q24.12",12,112241766,"BRAP, ALDH2","- ",null,null,217,null,null,"rs671-A","rs671",0,671,"missense",0,"NR",3e-24,23.5228787452803,null,1.67,"[1.58-1.76] ","Illumina [359,195]","N"]
["V4 (down-regulated)","12/29/2009",20031603,"Marroni F","08/01/2009","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/20031603","A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.","RR interval (heart rate)","2,325 European ancestry individuals","NR","1q44",1,243943084,"AKT3","- ",null,null,10000,null,null,"rs4132509-A","rs4132509",0,4132509,"intron",0,0.21,2e-06,5.69897000433601,null,0.18,"[0.10-0.26] unit decrease","Illumina [~318,327]","N"]
["V4 (down-regulated)","08/04/2009",19597492,"Benjamin EJ","07/13/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19597492?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.","Atrial fibrillation","3,413 cases, 37,105 referents","2,145 cases, 4,073 controls","1p36.22",1,11852516,"MTHFR, NPPA","- ",null,null,4524,null,null,"rs17375901-T","rs17375901",0,17375901,"intron",0,0.053,6e-07,6.22184874961635,null,1.26,null,"Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V4 (down-regulated)","08/07/2009",19584346,"Vasan RS","07/08/2009","JAMA","http://www.ncbi.nlm.nih.gov/pubmed/19584346?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.","Cardiac structure and function","12,612 European ancestry individuals","4,094 European ancestry individuals","16q23.1",16,78258810,"WWOX","- ",null,null,51741,null,null,"rs2059238-A","rs2059238",0,2059238,"intron",0,0.22,3e-06,5.52287874528033,"(LV wall thickness)",0.02,"[0.01-0.03] cm decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V4 (down-regulated)","07/24/2009",19578179,"Teichert M","07/04/2009","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19578179","A genome-wide association study of acenocoumarol maintenance dosage.","Acenocoumarol maintenance dosage","1,451 European ancestry individuals","287 European ancestry individuals","10q23.33",10,96547463,"CYP2C19","- ",null,null,1557,null,null,"rs12767583-?","rs12767583",0,12767583,"intron",0,"NR",3e-07,6.52287874528033,null,"NR","NR","Illumina [~550,000]","N"]
["V4 (down-regulated)","07/24/2009",19581569,"Treutlein J","07/01/2009","Arch Gen Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/19581569","Genome-wide association study of alcohol dependence.","Alcohol dependence","476 European ancestry cases, 1,358 European ancestry controls","1,024 European ancestry cases, 996 European ancestry controls","6q25.1",6,152157881,"ESR1","- ",null,null,2099,null,null,"rs6902771-C","rs6902771",0,6902771,"intron",0,0.51,8e-06,5.09691001300805,null,1.24,"[1.13-1.36] ","Illumina [524,396]","N"]
["V4 (down-regulated)","06/14/2009",19465909,"Jallow M","05/24/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19465909","Genome-wide and fine-resolution association analysis of malaria in West Africa.","Malaria","958 African ancestry cases, 1,382 African ancestry controls, all children","1,087 African ancestry cases, 2,376 African ancestry controls, all children","11p15.4",11,5225635,"HBB",null,283111,3043,null,3.71,21.06,"rs11036238-?","rs11036238",0,11036238,null,1,0.14,4e-11,10.397940008672,null,1.59,"[1.39-1.82] ","Affymetrix [402,814]","N"]
["V4 (down-regulated)","05/19/2009",19430483,"Newton-Cheh C","05/10/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19430483?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association study identifies eight loci associated with blood pressure.","Systolic blood pressure","34,433 individuals"," (up-regulated) to 100,347 white individuals,  (up-regulated) to 12,889 Indian Asian individuals","1p36.22",1,11862778,"MTHFR, NPPA, CLCN6, NPPB, AGTRAP","- ",null,null,4524,null,null,"rs17367504-G","rs17367504",0,17367504,"intron",0,0.14,2e-13,12.698970004336,null,0.85,"[0.63-1.07] mm Hg decrease","Affymetrix & Illumina [2,497,993] (imputed)","N"]
["V4 (down-regulated)","02/28/2009",19219042,"Zheng W","02/15/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19219042","Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1.","Breast cancer","1,505 Chinese ancestry cases, 1,522 Chinese ancestry controls","1,554 Chinese ancestry cases, 1,576 Chinese ancestry controls","6q25.1",6,151948366,"ESR1, C6orf97",null,80129,2099,null,6.04,63.27,"rs2046210-A","rs2046210",0,2046210,null,1,0.37,2e-15,14.698970004336,null,1.29,"[1.21-1.37] ","Affymetrix [ (up-regulated) to 607,728]","N"]
["V4 (down-regulated)","03/01/2009",19198610,"Gudbjartsson DF","02/08/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19198610","Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.","Eosinophil counts","9,392 European ancestry individuals","12,118 European ancestry individuals, 5,212 East Asian ancestry individuals","3q21.3",3,128260550,"GATA2",null,100129727,23434,null,3.08,30.29,"rs4857855-T","rs4857855",0,4857855,null,1,0.82,9e-17,16.0457574905606,"(European)",9.4,"[7.2-11.6] % standard unit increase","Illumina [312,179]","N"]
["V4 (down-regulated)","03/01/2009",19198609,"Kathiresan S","02/08/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19198609?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.","Myocardial infarction (early onset)","2,967 cases, 3,075 controls","9,746 cases, 9,746 controls","1p13.3",1,109818530,"CELSR2, PSRC1, SORT1","- ",null,null,1952,null,null,"rs646776-T","rs646776",0,646776,"nearGene-3",0,0.81,8e-12,11.096910013008,null,1.19,"[1.13-1.26] ","Affymetrix [~2.5 million] (imputed)","N"]
["V4 (down-regulated)","02/26/2009",19165232,"Otowa T","01/23/2009","J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/19165232","Genome-wide association study of panic disorder in the Japanese population.","Panic disorder","200 Japanese ancestry cases, 200 Japanese ancestry controls","NR","1q32.1",1,201262432,"PKP1","- ",null,null,5317,null,null,"rs860554-?","rs860554",0,860554,"intron",0,0.05,5e-08,7.30102999566398,null,"NR","NR","Affymetrix [253,903]","N"]
["V4 (down-regulated)","01/16/2009",19079262,"Styrkarsdottir U","12/14/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19079262?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","New sequence variants associated with bone mineral density.","Bone mineral density (hip)","6,865 individuals","8,510 individuals","6q25.1",6,151933175,"ESR1","- ",null,null,80129,null,null,"rs1038304-G","rs1038304",0,1038304,"intron",0,0.47,4e-10,9.39794000867203,null,0.08,"[0.06-0.11] s.d. decrease","Illumina [305,051]","N"]
["V4 (down-regulated)","01/16/2009",19079262,"Styrkarsdottir U","12/14/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19079262?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","New sequence variants associated with bone mineral density.","Bone mineral density (spine)","6,865 individuals","8,510 individuals","6q25.1",6,151936677,"C6orf97, ESR1","- ",null,null,80129,null,null,"rs6929137-A","rs6929137",0,6929137,"missense",0,0.3,2e-10,9.69897000433601,null,0.1,"[0.07-0.13] s.d. decrease","Illumina [305,051]","N"]
["V4 (down-regulated)","01/12/2009",19060911,"Aulchenko YS","12/07/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19060911?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.","Cholesterol, total","22,562 individuals","NR","1p13.3",1,109818530,"CELSR2","- ",null,null,1952,null,null,"rs646776-G","rs646776",0,646776,"nearGene-3",0,0.22,9e-22,21.0457574905606,null,0.13,"[NR] s.d. decrease","Illumina and Affymetrix [ (up-regulated) to ~600,000]","N"]
["V4 (down-regulated)","01/12/2009",19060911,"Aulchenko YS","12/07/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19060911?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.","LDL cholesterol","17,797 individuals","NR","1p13.3",1,109818530,"CELSR2","- ",null,null,1952,null,null,"rs646776-G","rs646776",0,646776,"nearGene-3",0,0.22,8e-23,22.096910013008,null,0.16,"[NR] s.d. decrease","Illumina and Affymetrix [ (up-regulated) to 600,000]","N"]
["V4 (down-regulated)","01/12/2009",19060906,"Kathiresan S","12/07/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19060906?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Common variants at 30 loci contribute to polygenic dyslipidemia.","LDL cholesterol","19,840 individuals"," (up-regulated) to 20,623 individuals","1p13.3",1,109817590,"CELSR2, PSRC1, SORT1","- ",null,null,1952,null,null,"rs12740374-T","rs12740374",0,12740374,"UTR-3",0,0.21,2e-42,41.698970004336,null,0.23,"[0.19-0.27] s.d. decrease","Affymetrix and Illumina [~2,600,000] (imputed)","N"]
["V4 (down-regulated)","01/12/2009",19060910,"Sabatti C","12/07/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19060910?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.","LDL cholesterol","4,763 individuals","NR","1p13.3",1,109818530,"CELSR2, PSRC1, SORT1","- ",null,null,1952,null,null,"rs646776-G","rs646776",0,646776,"nearGene-3",0,0.21,2e-12,11.698970004336,null,0.16,"[0.11-0.20] mmol/l decrease","Illumina [329,091]","N"]
["V4 (down-regulated)","01/16/2009",19010793,"Baranzini SE","11/14/2008","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19010793?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.","Normalized brain volume","753 cases,883 controls","NR","10q25.2",10,112006486,"MXI1","- ",null,null,4601,null,null,"rs716595-?","rs716595",0,716595,"intron",0,0.08,8e-06,5.09691001300805,null,"NR","NR","Illumina[551,642]","N"]
["V4 (down-regulated)","12/01/2008",18940312,"Yuan X","10/10/2008","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/18940312","Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.","Liver enzyme levels","7,751 European ancestry individuals","4,704 European ancestry and Asian Indian individuals","9q34.2",9,136323754,"ADAMTS13","- ",null,null,"11093;11094",null,null,"rs4962153-A","rs4962153",0,4962153,"intron;nearGene-5",0,"NR",8e-21,20.096910013008,"(ALP)",0.06,"[0.048-0.072] U/L decrease","Affymetrix and Illumina[ (up-regulated) to 496,032]","N"]
["V4 (down-regulated)","05/07/2009",18839057,"Lesch KP","10/07/2008","J Neural Transm","http://www.ncbi.nlm.nih.gov/pubmed/18839057?ordinalpos=16&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.","Attention deficit hyperactivity disorder","343 cases, 304 controls","NR","15q26.1",15,91450441,"MAN2A2","- ",null,null,4122,null,null,"rs2677744-?","rs2677744",0,2677744,"intron",0,"NR",1e-06,5.99999999999999,null,"NR","NR","Affymetrix [504,219](pooled)","N"]
["V4 (down-regulated)","11/25/2008",18711365,"Ferreira MA","08/17/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18711365?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Collaborative genome-wide association analysis s (up-regulated)ports a role for ANK3 and CACNA1C in bipolar disorder.","Bipolar disorder","4,387 cases,6,209 controls","NR","10q21.2",10,62179812,"ANK3","- ",null,null,288,null,null,"rs10994336-T","rs10994336",0,10994336,"intron",0,0.05,9e-09,8.04575749056067,null,1.45,"[NR] ","Affymetrix[1,769,948]imputed","N"]
["V4 (down-regulated)","11/25/2008",18587394,"Barrett JC","06/29/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18587394?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.","Crohn's disease","3,230 cases4,829 controls","1,339 trios, 2,325 cases, 1,809 controls","3p21.31",3,49721532,"MST1","- ",null,null,4485,null,null,"rs3197999-A","rs3197999",0,3197999,"missense",0,0.27,1e-12,12,null,1.2,"[NR] ","Affymetrix and Illumina[635,547](imputed)","N"]
["V4 (down-regulated)","11/25/2008",18521091,"Volpi S","06/03/2008","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/18521091?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia.","Response to iloperidone treatment (QT prolongation)","183 individuals","NR","4q32.3",4,169530258,"PALLD","- ",null,null,23022,null,null,"rs17054392-C","rs17054392",0,17054392,"intron",0,"NR",3e-06,5.52287874528033,null,"NR","NR","Affymetrix[339,272]","N"]
["V4 (down-regulated)","11/25/2008",18445777,"Styrkarsdottir U","04/29/2008","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/18445777?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Multiple genetic loci for bone mineral density and fractures.","Bone mineral density (hip)","5,861 individuals","7,925 individuals","6q25.1",6,151933175,"ESR1","- ",null,null,80129,null,null,"rs1038304-G","rs1038304",0,1038304,"intron",0,0.47,5e-09,8.30102999566398,null,0.08,"[0.06-0.11] s.d. decrease","Illumina[301,019]","N"]
["V4 (down-regulated)","11/25/2008",18445777,"Styrkarsdottir U","04/29/2008","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/18445777?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Multiple genetic loci for bone mineral density and fractures.","Bone mineral density (hip)","5,861 individuals","7,925 individuals","6q25.1",6,151901409,"ESR1, C6orf97","- ",null,null,80129,null,null,"rs4870044-T","rs4870044",0,4870044,"intron",0,0.28,2e-07,6.69897000433601,null,0.08,"[0.05-0.11] s.d. decrease","Illumina[301,019]","N"]
["V4 (down-regulated)","11/25/2008",18445777,"Styrkarsdottir U","04/29/2008","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/18445777?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Multiple genetic loci for bone mineral density and fractures.","Bone mineral density (spine)","5,861 individuals","7,925 individuals","6q25.1",6,151901409,"ESR1","- ",null,null,80129,null,null,"rs4870044-T","rs4870044",0,4870044,"intron",0,0.28,2e-11,10.698970004336,null,0.11,"[0.08-0.14] s.d. decrease","Illumina[301,019]","N"]
["V4 (down-regulated)","11/25/2008",18445777,"Styrkarsdottir U","04/29/2008","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/18445777?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Multiple genetic loci for bone mineral density and fractures.","Bone mineral density (spine)","5,861 individuals","7,925 individuals","6q25.1",6,151933175,"ESR1, C6orf97","- ",null,null,80129,null,null,"rs1038304-G","rs1038304",0,1038304,"intron",0,0.47,4e-11,10.397940008672,null,0.1,"[0.07-0.13] s.d. decrease","Illumina[301,019]","N"]
["V4 (down-regulated)","11/25/2008",18445777,"Styrkarsdottir U","04/29/2008","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/18445777?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Multiple genetic loci for bone mineral density and fractures.","Bone mineral density (spine)","5,861 individuals","7,925 individuals","6q25.1",6,152068364,"ESR1, C6orf97","- ",null,null,2099,null,null,"rs1999805-C","rs1999805",0,1999805,"intron",0,0.44,2e-08,7.69897000433601,null,0.09,"[0.06-0.12] s.d. decrease","Illumina[301,019]","N"]
["V4 (down-regulated)","11/25/2008",18372903,"Zeggini E","03/30/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18372903?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.","Type 2 diabetes","4,549 cases,5,579 controls","24,194 cases,55,598 controls","1p12",1,120517959,"NOTCH2, ADAM30","- ",null,null,4853,null,null,"rs10923931-T","rs10923931",0,10923931,"intron",0,0.11,4e-08,7.39794000867203,null,1.13,"[1.08-1.17] ","Affymetrix and Illumina[2,202,892](imputed)","N"]
["V4 (down-regulated)","11/25/2008",18262040,"Sandhu MS","02/09/2008","Lancet","http://www.ncbi.nlm.nih.gov/pubmed/18262040?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","LDL-cholesterol concentrations: a genome-wide association study.","LDL cholesterol","11,685 individuals","5,036 individuals","1p13.3",1,109822166,"CELSR2,PSRC1","- ",null,null,84722,null,null,"rs599839-G","rs599839",0,599839,"nearGene-3",0,0.19,1e-33,32.9999999999999,null,0.16,"[0.14-0.18] mmol/L decrease","Affymetrix and Illumina [ (up-regulated) to 461,986]","N"]
["V4 (down-regulated)","11/25/2008",18245381,"Uda M","02/05/2008","Proc Natl Acad Sci U S A","http://www.ncbi.nlm.nih.gov/pubmed/18245381?rdinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.","Fetal hemoglobin levels","4,305 individuals","521 individuals","11p15.4",11,5306509,"HBB",null,3046,403265,null,15.14,6.19,"rs4910742-A","rs4910742",0,4910742,null,1,0.93,1e-21,21,null,0.58,"[NR] s.d. decrease in HbF","Affymetrix [362,129]","N"]
["V4 (down-regulated)","11/25/2008",18193044,"Kathiresan S","01/13/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18193044?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.","LDL cholesterol","2,758 individuals","18,544 individuals","1p13.3",1,109818530,"CELSR2,PSRC1,SORT1","- ",null,null,1952,null,null,"rs646776-C","rs646776",0,646776,"nearGene-3",0,0.24,3e-29,28.5228787452803,null,0.16,"[0.14-0.18] % SD lower","Affymetrix[389,878]","N"]
["V4 (down-regulated)","11/25/2008",18193043,"Willer CJ","01/13/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18193043?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Newly identified loci that influence lipid concentrations and risk of coronary artery disease.","LDL cholesterol","8,589 individuals","7,440-10,783 individuals","1p13.3",1,109822166,"CELSR2,PSRC1,SORT1","- ",null,null,84722,null,null,"rs599839-A","rs599839",0,599839,"nearGene-3",0,0.77,6e-33,32.2218487496163,null,5.48,"[NR] mg/dl higher","Illumina and Affymetrix[~2,261,000] (imputed)","N"]
["V4 (down-regulated)","11/25/2008",18179892,"Wallace C","01/10/2008","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/18179892?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.","LDL cholesterol","1,955 hypertensive individuals","2,033 individuals in 519 families; 1,461 twins (1/pair selected randomly)","1p13.3",1,109822166,"CELSR2,PSRC1","- ",null,null,84722,null,null,"rs599839-G","rs599839",0,599839,"nearGene-3",0,0.24,1e-07,7,null,0.95,"[0.93-0.97] ","Affymetrix[400,496]","N"]
["V4 (down-regulated)","11/25/2008",17903305,"Murabito JM","09/19/2007","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/17903305?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study.","Breast cancer","1,345 individuals(Framingham)","NR","17q21.33",17,48274291,"COL1A1","- ",null,null,1277,null,null,"rs2075555-?","rs2075555",0,2075555,"intron",0,"NR",8e-08,7.09691001300805,null,"NR","NR","Affymetrix[70,897]","N"]
["V4 (down-regulated)","11/25/2008",17767159,"Menzel S","09/02/2007","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/17767159?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.","F-cell distribution","179 adults in  (up-regulated)per and lower 5%","90 adults","11p15.5",null,null,"HBB","- ",{"$nulls":5},"NR","NR",{"$nulls":4},0.33,2e-38,null,null,10.2,"[NR] % of variance explained","Illumina [308,015]","N"]
["V4 (down-regulated)","11/25/2008",17554300,"WTCCC","06/07/2007","Nature","http://www.ncbi.nlm.nih.gov/pubmed/17554300?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.","Crohn's disease","1,748 cases,2,938 controls","(see Parkes 2007)","3p21.31",3,49701983,"BSN, MST1","- ",null,null,8927,null,null,"rs9858542-A","rs9858542",0,9858542,"cds-synon",0,0.28,4e-08,7.39794000867203,null,1.09,"[0.96-1.24] ","Affymetrix[469,557]","N"]
["V4 (down-regulated)","11/25/2008",17554261,"Parkes M","06/06/2007","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/17554261?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.","Crohn's disease","1,748 cases,2,938 controls","1,182 cases,2,024 controls","3p21.31",3,49701983,"MST1","- ",null,null,8927,null,null,"rs9858542-?","rs9858542",0,9858542,"cds-synon",0,0.29,5e-08,7.30102999566398,null,1.17,"[1.14-1.31] ","see WTCCC","N"]
["V5 (up-regulated)","06/26/2013",23535033,"Sherva R","03/24/2013","Alzheimers Dement","http://www.ncbi.nlm.nih.gov/pubmed/23535033","Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.","Alzheimer's disease (cognitive decline)","303 European ancestry cases",null,"11p15.2",11,14224346,"SPON1,RRAS2,PSMA1","- ",null,null,10418,null,null,"rs11023139-?","rs11023139",0,11023139,null,0,0.05,7e-11,10.1549019599857,null,0.31,"unit decrease","Illumina [NR] (Imputed)","N"]
["V5 (up-regulated)","06/26/2013",23535033,"Sherva R","03/24/2013","Alzheimers Dement","http://www.ncbi.nlm.nih.gov/pubmed/23535033","Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.","Alzheimer's disease (cognitive decline)","303 European ancestry cases",null,"NR",5,153837106,"SAP30L","- ",null,null,79685,null,null,"rs148763909-?","rs148763909",0,148763909,"ncRNA",0,0.03,1e-08,8,null,0.15,"unit decrease","Illumina [NR] (Imputed)","N"]
["V5 (up-regulated)","05/31/2013",23449627,"Cousminer DL","02/27/2013","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23449627","Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.","Pubertal anthropometrics","7,161 European ancestry males, 6,879 European ancestry females","5,133 European ancestry males, 4,577 European ancestry females","1q32.1",1,205689807,"NUCKS1,RAB7L1","- ",null,null,64710,null,null,"rs823094-G","rs823094",0,823094,"intron",0,0.43,2e-07,6.69897000433601,"(Single Height)",0.05,"[0.03-0.07] unit decrease","Illumina & Affymetrix [~2.5 million] (imputed)","N"]
["V5 (up-regulated)","05/09/2013",23377640,"GENDEP Investigators","02/01/2013","Am J Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23377640 ","Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.","Major depressive disorder"," (up-regulated) to 2,256 European ancestry cases","NR","19q13.11",19,33089431,"PDCD5,ANKRD27,RGS9BP,NUDT19","- ",null,null,84079,null,null,"rs17692896-A","rs17692896",0,17692896,"intron",0,0.0739179,7e-07,6.15490195998574,"(% improvement - SSRI treated - 2 weeks)",0.44,"[0.27-0.61] unit decrease","Illumina & Affymetrix [1.2 million] (Imputed)","N"]
["V5 (up-regulated)","06/06/2013",23362303,"Wu JH","01/29/2013","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/23362303 ","Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.","Palmitic acid (16:0) plasma levels","8,961 European ancestry individuals",null,"7q36.1",7,152387869,"XRCC2 ",null,7516,644333,null,14.62,58.19,"rs10234749-T ","rs10234749 ",0,10234749,null,1,"NR ",4e-06,5.39794000867203,null,0.18,"unit decrease ","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (up-regulated)","03/22/2013",23269536,"Sun J","12/27/2012","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23269536","Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population.","Prostate-specific antigen levels","1,999 Chinese ancestry men","1,496 Chinese ancestry men","1q32.1",1,205638222,"SLC45A3, NUCKS1, RAB7L1, SLC41A1, FLJ32569","- ",null,null,85414,null,null,"rs12409639-A","rs12409639",0,12409639,"intron",0,0.11,2e-19,18.698970004336,null,0.2,"[NR] % higher levels","Illumina [>709,211] (imputed)","N"]
["V5 (up-regulated)","02/21/2013",23273568,"Yang W","12/27/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23273568","Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic l (up-regulated)us erythematosus in Asians.","Systemic l (up-regulated)us erythematosus","1,656 Han Chinese cases, 3,394 Han Chinese controls","3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls","6q23.3",6,138196066,"TNFAIP3","- ",null,null,7128,null,null,"rs2230926-G","rs2230926",0,2230926,"missense",0,0.02,1e-13,13,null,2.71,null,"Illumina [2,100,739] (imputed)","N"]
["V5 (up-regulated)","03/15/2013",23263486,"Kottgen A","12/23/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263486","Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.","Urate levels","49,825 European ancestry men, 60,522 European ancestry women"," (up-regulated) to 32,813 European ancestry individuals","7q11.23",7,72857049,"BAZ1B, MLXIPL","- ",null,null,9031,null,null,"rs1178977-A","rs1178977",0,1178977,"intron",0,0.81,1e-12,12,null,0.05,"[0.034-0.06] unit increase","Affymetrix, Illumina, Perlegen [2,450,547] (imputed)","N"]
["V5 (up-regulated)","02/27/2013",23247143,"Yu B","12/16/2012","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/23247143","Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.","Cardiac Troponin-T levels","9,491 European ancestry individuals,  (up-regulated) to 2,053 African American individuals","NR","6q23.3",6,138266685,"TNFAIP3",null,7128,100270919,null,62.23,49.72,"rs9321637-C","rs9321637",0,9321637,null,1,"NR",8e-06,5.09691001300805,"(Dichotomous variable)",2.17,"[1.56-3.13] ","Affymetrix and Illumina [~2.5 Million] (imputed)","N"]
["V5 (up-regulated)","03/19/2013",23222517,"van der Harst P","12/05/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23222517","Seventy-five genetic loci influencing the human red blood cell.","Red blood cell traits","62,553 European ancestry individuals, 9,308 South Asian ancestry individuals","63,506 European ancestry individuals","22q13.33",22,50971266,"ODF3B, TYMP, NCAPH2, SCO2","- ",null,null,440836,null,null,"rs140522-C","rs140522",0,140522,"nearGene-5",0,0.67,5e-23,22.3010299956639,"(EA, MCV)",0.29,"[0.23-0.35] unit increase","Illumina, Affymetrix & Perlegen [2,711,806] imputed","N"]
["V5 (up-regulated)","03/19/2013",23222517,"van der Harst P","12/05/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23222517","Seventy-five genetic loci influencing the human red blood cell.","Red blood cell traits","62,553 European ancestry individuals, 9,308 South Asian ancestry individuals","63,506 European ancestry individuals","3q29",3,195834357,"TFRC",null,100147766,131540,null,34.61,89.97,"rs11717368-C","rs11717368",0,11717368,null,1,0.52,7e-19,18.1549019599857,"(EA, MCH)",0.01,"[0.00016-0.01584] unit increase","Illumina, Affymetrix & Perlegen [2,711,806] imputed","N"]
["V5 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","7q11.23",7,75059331,"POM121C, PMS2L3","- ",null,null,100101267,null,null,"rs236670-C","rs236670",0,236670,"intron",0,0.005,3e-06,5.52287874528033,"(Diet protein )",0.03,"[NR]  %energy increase","Illumina [899,892]","N"]
["V5 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","12q21.2",12,76476956,"NAP1L1","- ",null,null,4673,null,null,"rs1368578-A","rs1368578",0,1368578,"intron",0,0.072,1e-06,5.99999999999999,"(HRmax )",0.04,"[NR]  bpm increase","Illumina [899,892]","N"]
["V5 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","1p36.32",1,2452979,"PANK4","- ",null,null,55229,null,null,"rs12073504-G","rs12073504",0,12073504,"intron",0,0.033,5e-06,5.30102999566398,"(IGFBP-3 )",0.03,"[NR]  ng/mL increase","Illumina [899,892]","N"]
["V5 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","12q24.23",12,118454669,"RFC5","- ",null,null,5985,null,null,"rs5745796-A","rs5745796",0,5745796,"missense",0,0.032,5e-06,5.30102999566398,"(IGFBP-3 )",0.03,"[NR]  ng/mL increase","Illumina [899,892]","N"]
["V5 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","8q13.1",8,66463478,"ARMC1","- ",null,null,286186,null,null,"rs6981992-A","rs6981992",0,6981992,"intron",0,0.489,8e-06,5.09691001300805,"(Sleep duration )",0.02,"[NR]  min/d increase","Illumina [899,892]","N"]
["V5 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","16p12.1",16,24578458,"RBBP6","- ",null,null,5930,null,null,"rs7195386-A","rs7195386",0,7195386,"intron",0,0.477,9e-06,5.04575749056067,"(Vigorous activity )",0.03,"[NR]  min/d increase","Illumina [899,892]","N"]
["V5 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","17q23.1",17,58024324,"RPS6KB1, TUBD1, NDUFB8P2, RNFT1","- ",null,null,6198,null,null,"rs1051424-G","rs1051424",0,1051424,"UTR-3",0,0.127,3e-06,5.52287874528033,"(Urinary free epinephrine )",0.03,"[NR]  nmol/d increase","Illumina [899,892]","N"]
["V5 (up-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","8q24.11",8,118909260,"EXT1","- ",null,null,2131,null,null,"rs7459527-A","rs7459527",0,7459527,"intron",0,0.093,2e-06,5.69897000433601,"(Cortisol )",0.03,"[NR]  ng/mL increase","Illumina [899,892]","N"]
["V5 (up-regulated)","02/13/2013",23180869,"Wu C","11/24/2012","Gut","http://www.ncbi.nlm.nih.gov/pubmed/23180869 ","Genome-wide association study of survival in patients with pancreatic adenocarcinoma.","Pancreatic cancer","642 European ancestry cases","363 Chinese ancestry cases","11p15.1",11,18384938,"GTF2H1","- ",null,null,2965,null,null,"rs9783347-A","rs9783347",0,9783347,"intron",0,0.3,9e-06,5.04575749056067,null,1.36,"[1.19-1.56] ","Illumina [2,731,086] (imputed)","N"]
["V5 (up-regulated)","02/01/2013",23143601,"Lan Q","11/11/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23143601","Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.","Lung cancer","5,510 East Asian ancestry cases, 4,544 East Asian ancestry controls","1,099 East Asian ancestry cases, 2,913 East Asian ancestry controls","2q23.3",2,152253918,"TNFAIP6, RIF1",null,7130,55183,null,17.36,12.48,"rs10197940-T","rs10197940",0,10197940,null,1,0.52,5e-06,5.30102999566398,null,1.12,"[1.06-1.18] ","Illumina [596,032]","N"]
["V5 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Crohn's disease"," (up-regulated) to 12,924 European ancestry cases,  (up-regulated) to 21,442 European ancestry controls "," (up-regulated) to 25,683 European ancestry cases,  (up-regulated) to 17,015 European ancestry controls ","1p13.2",1,114303808,"PTPN22,DCLRE1B",null,10745,54665,null,2.03,0.65,"rs6679677-C","rs6679677",0,6679677,null,1,0.907,2e-15,14.698970004336,null,1.2,"[1.129-1.268] ","Affyemtrix & Illumina [1.23 million] (imputed)","N"]
["V5 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","6q23.3",6,138006504,"TNFAIP3",null,391040,7128,null,140.92,181.82,"rs6920220-A","rs6920220",0,6920220,null,1,0.206,1e-21,21,null,1.1,"[1.064-1.141] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V5 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","17q23.1",17,57963537,"TUBD1,RPS6KB1","- ",null,null,51174,null,null,"rs1292053-G","rs1292053",0,1292053,"missense",0,0.446,9e-13,12.0457574905606,null,1.08,"[1.045-1.106] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V5 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Ulcerative colitis"," (up-regulated) to 12,924 European ancestry cases,  (up-regulated) to 21,442 European ancestry controls"," (up-regulated) to 25,683 European ancestry cases,  (up-regulated) to 17,015 European ancestry controls","4q24",4,103511114,"NFKB1,MANBA","- ",null,null,4790,null,null,"rs3774959-A","rs3774959",0,3774959,"intron",0,0.358,4e-12,11.397940008672,null,1.12,"[1.077-1.159] ","Affymetrix & Illumina [1.23 million] (imputed)","N"]
["V5 (up-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Ulcerative colitis"," (up-regulated) to 12,924 European ancestry cases,  (up-regulated) to 21,442 European ancestry controls"," (up-regulated) to 25,683 European ancestry cases,  (up-regulated) to 17,015 European ancestry controls","7q32.1",7,128573967,"IRF5,TNPO3,TSPAN33",null,375616,3663,null,23.19,4.03,"rs4728142-A","rs4728142",0,4728142,null,1,0.444,4e-14,13.397940008672,null,1.1,"[1.066-1.143] ","Affymetrix & Illumina [1.23 million] (imputed)","N"]
["V5 (up-regulated)","01/09/2013",23053960,"Lee YH","10/07/2012","Mol Biol Rep","http://www.ncbi.nlm.nih.gov/pubmed/23053960","Genome-wide pathway analysis of genome-wide association studies on systemic l (up-regulated)us erythematosus and rheumatoid arthritis.","Systemic l (up-regulated)us erythematosus","1,527 European ancestry cases, 3,421 European ancestry controls, ","NR","7q32.1",7,128617466,"TNPO3","- ",null,null,23534,null,null,"rs12531711-A","rs12531711",0,12531711,"intron",0,"NR",6e-13,12.2218487496163,null,1.59,"[1.403-1.808] ","Illumina [737,984]","N"]
["V5 (up-regulated)","12/21/2012",23022100,"Franceschini N","09/26/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23022100","Discovery and fine mapping of serum protein loci through transethnic meta-analysis.","Serum albumin level"," (up-regulated) to 53,190 European ancestry individuals, 9,380 Japanese ancestry individuals","NR","19q13.33",19,50000009,"RPS11, FCGRT","- ",null,null,"6205;84546",null,null,"rs2280401-A","rs2280401",0,2280401,"intron;nearGene-5",0,0.17,6e-09,8.22184874961635,null,0.01,"[0.0089-0.0179] unit increase","Illumina and Affymetrix [~2.5 million] (imputed)","N"]
["V5 (up-regulated)","12/21/2012",23022100,"Franceschini N","09/26/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23022100","Discovery and fine mapping of serum protein loci through transethnic meta-analysis.","Serum albumin level"," (up-regulated) to 53,190 European ancestry individuals, 9,380 Japanese ancestry individuals","NR","19q13.33",19,50000009,"RPS11, FCGRT","- ",null,null,"6205;84546",null,null,"rs2280401-A","rs2280401",0,2280401,"intron;nearGene-5",0,0.17,8e-07,6.09691001300805,"(EA)",0.01,"[0.0074-0.0168] unit increase","Illumina and Affymetrix [~2.5 million] (imputed)","N"]
["V5 (up-regulated)","12/21/2012",23022100,"Franceschini N","09/26/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23022100","Discovery and fine mapping of serum protein loci through transethnic meta-analysis.","Serum total protein level"," (up-regulated) to 25,539 European ancestry individuals, 10,168 Japanese ancestry individuals","NR","19q13.33",19,50000009,"RPS11, FCGRT","- ",null,null,"6205;84546",null,null,"rs2280401-A","rs2280401",0,2280401,"intron;nearGene-5",0,0.16,7e-08,7.15490195998574,"(Japanese)",0.05,"[0.032-0.068] unit increase","Illumina and Affymetrix [~2.5 million] (imputed)","N"]
["V5 (up-regulated)","12/21/2012",23022100,"Franceschini N","09/26/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23022100","Discovery and fine mapping of serum protein loci through transethnic meta-analysis.","Serum total protein level"," (up-regulated) to 25,539 European ancestry individuals, 10,168 Japanese ancestry individuals","NR","19q13.33",19,50000009,"RPS11, FCGRT","- ",null,null,"6205;84546",null,null,"rs2280401-A","rs2280401",0,2280401,"intron;nearGene-5",0,0.16,3e-06,5.52287874528033,null,0.02,"[0.012-0.030] unit increase","Illumina and Affymetrix [~2.5 million] (imputed)","N"]
["V5 (up-regulated)","11/28/2012",22990020,"Huang J","09/18/2012","Blood","http://www.ncbi.nlm.nih.gov/pubmed/22990020","Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.","Plasminogen activator inhibitor type 1 levels (PAI-1)","19,599 European ancestry individuals","10,764 European ancestry individuals","7q22.1",7,100512119,"ACHE, SLC12A9, TRIP6, SRRT, UFSP1, EPHB4, MUC3",null,43,100271241,null,18.58,13.84,"rs6976053-?","rs6976053",0,6976053,null,1,"NR",6e-13,12.2218487496163,null,0.05,"[NR] unit increase","Affymetrix & Illumina [2,445,683] (imputed)","N"]
["V5 (up-regulated)","11/29/2012",23000144,"Nakamura M","09/18/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23000144","Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.","Primary biliary cirrhosis","487 Japanese ancestry cases, 476 Japanese ancestry controls","787 Japanese ancestry cases, 615 Japanese ancestry controls","4q23",4,99796784,"NFKB1",null,132556,1977,null,134.14,2.82,"rs7665590-G","rs7665590",0,7665590,null,1,"NR",1e-07,7,null,1.35,"[1.21-1.52] ","Affymetrix [421,245]","N"]
["V5 (up-regulated)","11/28/2012",23028356,"Myouzen K","09/13/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23028356","Functional variants in NFKBIE and RTKN2 involved in activation of the NF-&#x003ba;B pathway are associated with rheumatoid arthritis in Japanese.","Rheumatoid arthritis","2,303 Japanese ancestry cases, 3,380 Japanese ancestry controls","5,604 Japanese ancestry cases, 31,982 Japanese ancestry controls","6p21.1",6,44232920,"NFKBIE","- ",null,null,4794,null,null,"rs2233434-G","rs2233434",0,2233434,"missense",0,0.215,1e-15,15,null,1.2,"[1.15-1.26] ","Illumina [NR]","N"]
["V5 (up-regulated)","11/30/2012",22976474,"Siddiq A","09/13/2012","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/22976474","A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11.","Breast cancer","3,666 European ancestry cases, 28,864 European ancestry controls, 1,004 African American cases, 2,744 African American controls","562 European ancestry cases, 6,410 European ancestry controls, 84 Japanese ancestry cases, 830 Japanese ancestry controls, 300 Hispanic/Latin American cases, 1,164 Hispanic/Latin American controls","20q11.22",20,32588095,"RALY, EIF2S2, ASIP","- ",null,null,22913,null,null,"rs2284378-T","rs2284378",0,2284378,"intron",0,0.31,1e-08,8,null,1.16,"[1.10-1.22] ","Illumina [2,608,509] (imputed)","N"]
["V5 (up-regulated)","11/02/2012",22939635,"Reiner AP","08/28/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/22939635","Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.","C-reactive protein","8,280 African American women, 3,548 Hispanic/Latin American ancestry women","3,787 African American women, 3,548 Hispanic/Latin American ancestry women, 5,656 European ancestry individuals","12q24.31",12,121435587,"HNF1A, OASL, C12orf43","- ",null,null,6927,null,null,"rs2259816-T","rs2259816",0,2259816,"intron",0,0.379,3e-10,9.52287874528033,"(HA women)",0.14,"[0.092-0.190] unit increase","Affymetrix [ (up-regulated) to 2,203,609] (imputed)","N"]
["V5 (up-regulated)","10/12/2012",22903471,"Hibar DP","08/18/2012","Brain Imaging Behav","http://www.ncbi.nlm.nih.gov/pubmed/22903471","Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N&#x02009;=&#x02009;1345 young and elderly subjects.","Lentiform nucleus volume ","162 European ancestry Alzheimer's disease cases, 346 European ancestry mild cognitive impairment cases, 198 European ancestry controls, 639 European ancestry individuals from 364 families","NR","6q23.2",6,131282210,"EPB41L2","- ",null,null,2037,null,null,"rs6941712-C","rs6941712",0,6941712,"intron",0,0.13,5e-06,5.30102999566398,null,149.67,"[NR] unit decrease","Illumina [2,380,200] (imputed)","N"]
["V5 (up-regulated)","08/15/2012",22703881,"Tang W","06/14/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/22703881","Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.","Activated partial thromboplastin time","9,240 European ancestry individuals","2611 European ancestry individuals","9q34.2",9,136137065,"ABO, LOC653163, SURF2, SURF4, ADAMTS13, C9orf7","- ",null,null,28,null,null,"rs687621-A","rs687621",0,687621,"intron",0,"NR",9e-100,99.0457574905606,null,0.82,"[0.73-0.90] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (up-regulated)","08/15/2012",22703881,"Tang W","06/14/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/22703881","Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.","Prothrombin time","2,583 European ancestry individuals","986 European ancestry individuals","20q11.22",20,33722863,"EDEM2, TRPC4AP, PROCR, MYH7B,","- ",null,null,55741,null,null,"rs2295888-A","rs2295888",0,2295888,"intron",0,"NR",5e-13,12.3010299956639,null,0.02,"[0.012-0.028] unit decrease","Illumina [~2.5 million] (imputed)","N"]
["V5 (up-regulated)","08/14/2012",22688191,"Bergen SE","06/12/2012","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22688191","Genome-wide association study in a Swedish population yields s (up-regulated)port for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.","Bipolar disorder and schizophrenia","2,111 European ancestry schizophrenia cases, 836 European ancestry bipolar disorder cases, 2,535 European ancestry controls","NR","2q33.3",2,207121782,"ZDBF2, GPR1, ADAM23",null,2825,100874430,null,39.01,2.57,"rs2058710-A","rs2058710",0,2058710,null,1,"NR",9e-06,5.04575749056067,null,1.24,"[NR] ","Affymetrix [745,006]","N"]
["V5 (up-regulated)","07/17/2012",22658654,"Chung SJ","05/30/2012","Parkinsonism Relat Disord","http://www.ncbi.nlm.nih.gov/pubmed/22658654","Genomic determinants of motor and cognitive outcomes in Parkinson's disease.","Parkinson's disease (motor and cognition)","443 European ancestry cases","NR","5q23.2",5,126181862,"LMNB1",null,4001,115123,null,9.15,21.54,"rs959573-?","rs959573",0,959573,null,1,"NR",5e-06,5.30102999566398,"(cognitive outcome)",1.92,"[1.49-2.50] ","NR [198,345]","N"]
["V5 (up-regulated)","08/14/2012",22832960,"Service SK","05/15/2012","Transl Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22832960","A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.","Temperament"," (up-regulated) to 12,433 individuals","NR","21q22.11",21,33552512,"C21orf45",null,30811,54069,null,176.14,88.02,"rs2833693-T","rs2833693",0,2833693,null,1,0.723,4e-06,5.39794000867203,"(Reward dependence)",0.17,"unit decrease","Affymetrix & Illumina [1,252,222] (imputed)","N"]
["V5 (up-regulated)","08/17/2012",22589738,"Fox CS","05/10/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22589738","Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.","Visceral fat","5,560 European ancestry women and 4,997 European ancestry men","NR","5q35.1",5,170720733,"RANBP17","- ",null,null,64901,null,null,"rs2278255-G","rs2278255",0,2278255,"intron",0,0.06,5e-06,5.30102999566398,"(men)","NR","NR","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V5 (up-regulated)","04/11/2013",22504420,"Estrada K","04/15/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22504420","Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.","Bone mineral density"," (up-regulated) to 32,961 European and East Asian ancestry individuals"," (up-regulated) to 50,933 European and East Asian ancestry individuals","19q13.11",19,33599127,"GPATCH1","- ",null,null,55094,null,null,"rs10416218-T","rs10416218",0,10416218,"intron",0,0.73,7e-11,10.1549019599857,"(LSBMD)",0.04,"[NR] unit decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (up-regulated)","05/25/2012",22504419,"Taal HR","04/15/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22504419","Common variants at 12q15 and 12q24 are associated with infant head circumference.","Head circumference (infant)","10,768 European ancestry infants","8,321 European ancestry infants","12q24.31",12,123822711,"SBNO1","- ",null,null,55206,null,null,"rs7980687-A","rs7980687",0,7980687,"intron",0,0.2,8e-09,8.09691001300805,null,0.07,"[0.049-0.099] SD increase","Affymetrix & Illumina [~2.4 million] (imputed)","N"]
["V5 (up-regulated)","06/19/2012",22491018,"Wang J","04/10/2012","Pharmacogenomics J","http://www.ncbi.nlm.nih.gov/pubmed/22491018","Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.","Response to tocilizumab in rheumatoid arthritis","1,157 European and other ancestry rheumatoid arthritis cases","526 European and other ancestry rheumatoid arthritis cases","15q25.1",15,78833223,"PSMA4","- ",null,null,5685,null,null,"rs12901682-?","rs12901682",0,12901682,"intron",0,0.017,4e-08,7.39794000867203,"(CSJC , EA, RF-)",135.02,"[NR] unit decrease","Illumina [534,053]","N"]
["V5 (up-regulated)","05/25/2012",22484627,"Bradfield JP","04/08/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22484627","A genome-wide association meta-analysis identifies new childhood obesity loci.","Obesity","5,530 European ancestry cases, 8,318 European ancestry controls","2,214 European ancestry cases, 2,674 European ancestry controls","4q25",4,113311790,"ALPK1","- ",null,null,80216,null,null,"rs4833407-?","rs4833407",0,4833407,"intron",0,"NR",1e-06,5.99999999999999,null,1.11,"[1.065-1.160] ","Affymetrix & Illumina [2.7 million] (imputed)","N"]
["V5 (up-regulated)","05/15/2012",22488850,"Zuo L","04/04/2012","Am J Med Genet B Neuropsychiatr Genet","http://www.ncbi.nlm.nih.gov/pubmed/22488850","Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.","Alcohol and nictotine co-dependence","818 European ancestry cases, 1,396 European ancestry controls, 449 African American cases, 480 African American controls","NR","6p24.1",6,12048827,"HIVEP1","- ",null,null,3096,null,null,"rs1570989-?","rs1570989",0,1570989,"intron",0,"NR",2e-06,5.69897000433601,null,"NR","NR","Illumina [805,814]","N"]
["V5 (up-regulated)","04/24/2012",22479419,"Liou YJ","03/27/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/22479419","Genome-wide association study of treatment refractory schizophrenia in Han Chinese.","Schizophrenia (treatment refractory) ","522 Han Chinese cases, 806 Han Chinese controls","273 Han Chinese cases","4q24",4,103457418,"NFKB1","- ",null,null,4790,null,null,"rs230529-T","rs230529",0,230529,"intron",0,0.47,2e-07,6.69897000433601,null,1.45,"[1.26-1.66] ","Affymetrix [694,436]","N"]
["V5 (up-regulated)","04/27/2012",22446963,"Okada Y","03/25/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22446963","Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.","Rheumatoid arthritis","4,074 Japanese ancestry cases, 16,891 Japanese ancestry controls","5,277 Japanese ancestry cases, 21,684 Japanese ancestry controls","6p21.1",6,44232920,"NFKBIE","- ",null,null,4794,null,null,"rs2233434-G","rs2233434",0,2233434,"missense",0,0.21,6e-19,18.2218487496163,null,1.19,"[1.15-1.24] ","Affymetrix & Illumina [1,948,139] ","N"]
["V5 (up-regulated)","04/03/2012",22412388,"Kenny EE","03/08/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22412388","A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.","Crohn's disease","737 Ashkenazi Jewish cases, 2,257  Ashkenazi Jewish controls","971 Ashkenazi Jewish cases, 2,124 Ashkenazi Jewish controls","8q21.11",8,74007347,"C8orf84, TERF1, RPL7, RDH10, KCNB2","- ",null,null,157869,null,null,"rs12677663-T","rs12677663",0,12677663,"nearGene-5",0,0.659,2e-08,7.69897000433601,null,1.15,"[1.04-1.28] ","Affyemtrix & Illumina [1,060,934] (imputed)","N"]
["V5 (up-regulated)","03/30/2012",22365631,"Greenwood TA","02/22/2012","Biol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22365631","Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci.","Temperament (bipolar disorder)","1,263 European ancestry cases and 1,434 European ancestry controls","NR","22q13.31",22,45961904,"FBLN1","- ",null,null,2192,null,null,"rs1985671-?","rs1985671",0,1985671,"intron",0,"NR",2e-08,7.69897000433601,"(Hyperthymic)",1.06,"[NR] unit decrease","Affymetrix [703,012]","N"]
["V5 (up-regulated)","03/14/2012",22331829,"Chasman DI","02/13/2012","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/22331829","Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (J (up-regulated)ITER) trial.","Response to statin therapy (LDL-C)","6,989 European ancestry individuals","NR","6q23.2",6,131256364,"EPB41L2","- ",null,null,2037,null,null,"rs7769153-?","rs7769153",0,7769153,"intron",0,"NR",2e-07,6.69897000433601,"(fractional LDL-C reduction)",10.3,"[6.77-13.83] % increase","Illumina [814,418]","N"]
["V5 (up-regulated)","04/25/2012",22443383,"Oudot-Mellakh T","01/16/2012","Br J Haematol","http://www.ncbi.nlm.nih.gov/pubmed/22443383","Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project.","Hemostatic factors and hematological phenotypes","951 European ancestry individuals","NR","20q11.22[rs17310467]; 20q11.22[rs6088735]",null,null,"GSS, EDEM2, PROCR","- ",{"$nulls":5},"4-SNP haplotype","rs17310467, rs6088735, rs6060278, rs867186",{"$nulls":4},0.105,4e-34,null,"(PC levels)",19.27,"[16.174-22.372] iu/ml increase (GCTG)","Illumina [472,123]","N"]
["V5 (up-regulated)","01/18/2012",22158540,"Wu C","12/11/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22158540","Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.","Pancreatic cancer","981 Chinese ancestry cases, 1,991 Chinese ancestry contorls.","2,603 Chinese ancestry cases, 2,877 Chinese ancestry controls.","3q29",3,195751630,"TFRC",null,255812,7037,null,34.48,24.53,"rs4927850-A","rs4927850",0,4927850,null,1,"NR",2e-07,6.69897000433601,null,1.24,"[1.14-1.35] ","Affymetrix [666,141]","N"]
["V5 (up-regulated)","01/17/2012",22190364,"Patsopoulos NA","12/01/2011","Ann Neurol","http://www.ncbi.nlm.nih.gov/pubmed/22190364","Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.","Multiple sclerosis","5,545 European ancestry cases, 12,153 European ancestry controls","NR","17q21.32",17,45768836,"KPNB1, TBKBP1, TBX21",null,3837,9755,null,7.83,3.79,"rs8070463-T","rs8070463",0,8070463,null,1,0.5,1e-07,7,null,1.15,"[NR] ","Affymetrix & Illumina [2,529,394]","N"]
["V5 (up-regulated)","11/25/2011",22021425,"Carty CL","10/21/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/22021425","Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe).","Height","8,149 African American ancestry women"," (up-regulated) to 20,809 African American ancestry and African ancestry individuals","18q21.1",18,46587654,"DYM","- ",null,null,54808,null,null,"rs1787200-T","rs1787200",0,1787200,"intron",0,0.37,7e-10,9.15490195998574,null,0.04,"[0.024-0.064] unit increase","Affymetrix [855,034]","N"]
["V5 (up-regulated)","11/18/2011",22001757,"Chambers JC","10/16/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22001757","Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.","Liver enzyme levels (gamma-glutamyl transferase)"," (up-regulated) to 52,350 European ancestry individuals,  (up-regulated) to 8,739 Indian Asian individuals","NR","1p13.3",1,111684276,"CEPT1, DENND2D","- ",null,null,"10390;128338",null,null,"rs1335645-A","rs1335645",0,1335645,"intron;nearGene-5",0,0.88,7e-09,8.15490195998574,null,4.3,"[3.50-5.20] % increase","Affymetrix, Illumina, and Perlegen [~2.6 million] (imputed)","N"]
["V5 (up-regulated)","12/10/2011",21983787,"Barrett JH","10/09/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21983787","Genome-wide association study identifies three new melanoma susceptibility loci.","Melanoma","2,804 European ancestry cases, 7,618 European ancestry controls","5,551 European ancestry cases, 7,449 European ancestry controls","9p21.3",9,21816528,"CDKN2A, MTAP","- ",null,null,4507,null,null,"rs7023329-?","rs7023329",0,7023329,"intron",0,0.51,7e-09,8.15490195998574,null,1.2,"[1.14-1.28] ","Illumina [594,997]","N"]
["V5 (up-regulated)","11/04/2011",21979947,"Li X","10/06/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21979947","A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries.","Corneal structure","222 European ancestry cases, 3,324 European ancestry controls","304 European ancestry cases, 518 European ancestry controls, 146 European ancestry cases from 70 families, 161 European ancestry controls from 70 families","2q21.3",2,135803425,"RAB3GAP1",null,80122,22930,null,21.18,6.41,"rs4954218-?","rs4954218",0,4954218,null,1,"NR",1e-09,8.99999999999999,null,1.61,null,"Illumina [~290,000]","N"]
["V5 (up-regulated)","11/08/2011",21998595,"N'Diaye A","10/06/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21998595","Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.","Height","20,427 African ancestry individuals"," (up-regulated) to 16,436 African American individuals","18q21.1",18,46587654,"DYM","- ",null,null,54808,null,null,"rs1787200-A","rs1787200",0,1787200,"intron",0,0.37,1e-10,10,null,0.05,"[0.037-0.069] unit increase","Affymetrix & Illumina [3,310,998] (imputed)","N"]
["V5 (up-regulated)","10/19/2011",21926972,"Sklar P","09/18/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21926972","Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.","Bipolar disorder","7,481 European ancestry cases, 9,250 European ancestry controls","4,496 European ancestry cases, 42,422 European ancestry controls","2q11.2",2,99382892,"TXNDC9, TSGA10, REV1, MRPL30, MITD1, MGAT4A, LYG1, LYG2, LIPT1, EIF5B, C2orf55, C2orf15",null,100130391,343990,null,70.94,27.42,"rs7578035-G","rs7578035",0,7578035,null,1,"NR",3e-06,5.52287874528033,null,1.09,"[NR] ","Affymetrix & Illumina [2,415,422] (imputed)","N"]
["V5 (up-regulated)","10/21/2011",21909115,"Ehret GB","09/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21909115","Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.","Diastolic blood pressure","69,395 European ancestry individuals"," (up-regulated) to 133,361 European ancestry individuals","4q32.1",4,156645513,"GUCY1A3, GUCY1B3","- ",null,null,2982,null,null,"rs13139571-C","rs13139571",0,13139571,"intron",0,0.76,2e-10,9.69897000433601,null,0.26,"[NR] mmHg increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (up-regulated)","10/21/2011",21909115,"Ehret GB","09/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21909115","Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.","Systolic blood pressure","69,395 European ancestry individuals"," (up-regulated) to 133,361 European ancestry individuals","4q32.1",4,156645513,"GUCY1A3, GUCY1B3","- ",null,null,2982,null,null,"rs13139571-C","rs13139571",0,13139571,"intron",0,0.76,1e-06,5.99999999999999,null,0.32,"[NR] mmHg increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (up-regulated)","10/11/2011",21909109,"Kim YJ","09/11/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21909109","Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.","Metabolite levels","12,545 Korean ancestry individuals"," (up-regulated) to 30,395 East Asian ancestry individuals","19q13.33",19,50000009,"RPS11","- ",null,null,"6205;84546",null,null,"rs2280401-A","rs2280401",0,2280401,"intron;nearGene-5",0,0.17,9e-13,12.0457574905606,"(ALB)",0.03,"[0.021-0.037] g/dL increase","Affymetrix [~2.2 million] (imputed)","N"]
["V5 (up-regulated)","10/11/2011",21909110,"Wain LV","09/11/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21909110","Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.","Blood pressure","74,064 European ancestry individuals","48,607 European ancestry individuals","4q32.1",4,156645513,"GUCY1A3, GUCY1B3","- ",null,null,2982,null,null,"rs13139571-C","rs13139571",0,13139571,"intron",0,0.74,3e-07,6.52287874528033,"(Mean Arterial Pressure)",0.29,"[0.18-0.40] mmHg increase","Affymetrix, Illumina, and Perlegen [NR] (imputed)","N"]
["V5 (up-regulated)","10/24/2012",21833088,"Sawcer S","08/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21833088","Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.","Multiple sclerosis","9,772 European ancestry cases, 16,849 European ancestry controls","4,218 European ancestry cases, 7,296 European ancestry controls","4q24",4,103578637,"MANBA, NFKB1","- ",null,null,4126,null,null,"rs228614-G","rs228614",0,228614,"intron",0,"NR",1e-07,7,null,1.09,"[1.07-1.1] ","Illumina [465,434]","N"]
["V5 (up-regulated)","10/24/2012",21833088,"Sawcer S","08/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21833088","Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.","Multiple sclerosis","9,772 European ancestry cases, 16,849 European ancestry controls","4,218 European ancestry cases, 7,296 European ancestry controls","22q13.33",22,50971266,"ODF3B, SCO2","- ",null,null,440836,null,null,"rs140522-A","rs140522",0,140522,"nearGene-5",0,"NR",2e-08,7.69897000433601,null,1.1,"[1.09-1.12] ","Illumina [465,434]","N"]
["V5 (up-regulated)","10/24/2012",21833088,"Sawcer S","08/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21833088","Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.","Multiple sclerosis","9,772 European ancestry cases, 16,849 European ancestry controls","4,218 European ancestry cases, 7,296 European ancestry controls","12q14.1",12,58133256,"AGAP2, CYP27B1","- ",null,null,116986,null,null,"rs12368653-A","rs12368653",0,12368653,"intron",0,"NR",2e-09,8.69897000433601,"(Conditioned on rs7238078)",1.1,"[1.09-1.12] ","Illumina [465,434]","N"]
["V5 (up-regulated)","09/08/2011",21799462,"Srinivasan Y","07/27/2011","Pharmacogenet Genomics","http://www.ncbi.nlm.nih.gov/pubmed/21799462","Genome-wide association study of epirubicin-induced leukopenia in Japanese patients.","Epirubicin-induced leukopenia ","67 Japanese ancestry cases, 203 Japanese ancestry controls","48 Japanese ancestry cases","4q25",4,113328078,"ALPK1","- ",null,null,80216,null,null,"rs6838440-C","rs6838440",0,6838440,"intron",0,0.51,3e-06,5.52287874528033,null,2.1,"[1.49-2.96] ","Illumina [478,359]","N"]
["V5 (up-regulated)","08/03/2011",21750679,"Allanore Y","07/07/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21750679","Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.","Systemic sclerosis","564 European ancestry cases, 1,776 European ancestry controls","1,682 European ancestry cases, 3,926 European ancestry controls","7q32.1",7,128594183,"TNPO3, IRF5","- ",null,null,23534,null,null,"rs10488631-C","rs10488631",0,10488631,"nearGene-3",0,0.09,4e-07,6.39794000867203,null,1.35,"[1.20-1.51] ","Illumina [489,814]","N"]
["V5 (up-regulated)","07/20/2011",21658281,"Aouizerat BE","06/10/2011","BMC Cardiovasc Disord","http://www.ncbi.nlm.nih.gov/pubmed/21658281","GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.","Sudden cardiac arrest","89 European ancestry cases, 520 European ancestry controls","NR","2p25.1",2,11510948,"E2F6","- ",null,null,650157,null,null,"rs6716724-?","rs6716724",0,6716724,"intron",0,0.18,6e-07,6.22184874961635,"(Recessive)",1.39,"[1.22-1.57] ","Affymetrix [319,222]","N"]
["V5 (up-regulated)","06/04/2011",21606135,"Wild PS","05/23/2011","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/21606135","A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease.","Coronary heart disease","2,078 European descent cases, 2,953 European descent controls","19,350 European descent cases, 35,408 European descent controls","9p21.3",9,22031005,"MTAP","- ",null,null,100048912,null,null,"rs7865618-A","rs7865618",0,7865618,"intron",0,0.59,2e-27,26.698970004336,null,1.18,"[1.14-1.21] ","Affymetrix [608,247]","N"]
["V5 (up-regulated)","06/01/2011",21540461,"Kim DH","05/03/2011","Blood","http://www.ncbi.nlm.nih.gov/pubmed/21540461","A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia.","Chronic myeloid leukemia","201 Korean ancestry cases, 497 Korean ancestry controls","237 Korean ancestry cases, 1,000 Korean ancestry controls, 232 European ancestry cases, 576 European ancestry controls","6q25.1",6,151907748,"MTHFD1L, AKAP12, ZBTB2, RMND1, C6orf211, C6orf97, ESR1","- ",null,null,80129,null,null,"rs4869742-T","rs4869742",0,4869742,"intron",0,0.77,2e-06,5.69897000433601,null,1.67,"[1.35-2.04] ","Affymetrix [456,522]","N"]
["V5 (up-regulated)","04/12/2011",21399635,"Mells GF","03/13/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21399635","Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.","Primary biliary cirrhosis","2,774 European ancestry cases, 9,814 European ancestry controls","620 European ancestry cases, 2,514 European ancestry controls","4q24",4,103551603,"NFKB1",null,4790,100271166,null,13.14,32.14,"rs7665090-C","rs7665090",0,7665090,null,1,0.52,4e-12,11.397940008672,null,1.26,"[1.18-1.34] ","Illumina [507,467]","N"]
["V5 (up-regulated)","03/29/2011",21307088,"Khor CC","02/09/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21307088","Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area.","Optic disc parameters","2,132 Indian ancestry individuals, 2,313 Malay ancestry individuals","9,326 European ancestry individuals","22q13.1",22,37919267,"CARD10",null,29775,11135,null,4.06,37.2,"rs9607469-A","rs9607469",0,9607469,null,1,"0.14 (Rotterdam)",3e-12,11.5228787452803,null,0.05,"[0.04-0.06] mm2 increase","Illumina [551,808]","N"]
["V5 (up-regulated)","03/29/2011",21297633,"Anderson CA","02/06/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21297633","Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.","Ulcerative colitis","6,687 European ancestry cases, 19,718 European ancestry controls","9,628 European ancestry cases, 12,917 European ancestry controls","7q32.1",7,128573967,"IRF5, TNPO3",null,375616,3663,null,23.19,4.03,"rs4728142-A","rs4728142",0,4728142,null,1,0.44,2e-08,7.69897000433601,null,1.07,"[1.03-1.11] ","Affymetrix & Illumina [~1.1 million] (imputed)","N"]
["V5 (up-regulated)","03/28/2011",21348951,"Parsa A","02/01/2011","Clin Transl Sci","http://www.ncbi.nlm.nih.gov/pubmed/21348951","Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.","Cardiac hypertrophy","851 Old Order Amish individuals",null,"10q21.1",10,57416961,"ZWINT",null,100463289,389970,null,56.47,9.94,"rs1916521-?","rs1916521",0,1916521,null,1,"NR",5e-07,6.30102999566398,"(recessive)","NR","NR","Affymetrix [361,034]","N"]
["V5 (up-regulated)","01/15/2011",21203500,"Lauc G","12/23/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21203500","Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1&#x003b1; as a master regulator of plasma protein fucosylation.","N-glycan levels","1,822 Croatian individuals, 737 Scottish individuals","NR","12q24.31",12,121403724,"HNF1A,C12orf43,OASL",null,643550,283460,null,48.64,3.92,"rs7953249-G","rs7953249",0,7953249,null,1,0.45,2e-08,7.69897000433601,"(DG7)",0.17,"[0.11-0.23] unit decrease","Illumina [~300,000]","N"]
["V5 (up-regulated)","01/15/2011",21203500,"Lauc G","12/23/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21203500","Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1&#x003b1; as a master regulator of plasma protein fucosylation.","N-glycan levels","1,822 Croatian individuals, 737 Scottish individuals","NR","12q24.31",12,121438844,"HNF1A,C12orf43,OASL","- ",null,null,6927,null,null,"rs735396-G","rs735396",0,735396,"intron",0,0.38,4e-08,7.39794000867203,"(DG11)",0.17,"[0.11-0.23] unit increase","Illumina [~300,000]","N"]
["V5 (up-regulated)","01/07/2011",21124955,"Marzi C","11/18/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21124955","Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A.","Amyloid A Levels","4,212 European ancestry individuals","2,136 European ancestry individuals","11p15.1",11,18323517,"HPS5, GTF2H1","- ",null,null,11234,null,null,"rs4353250-T","rs4353250",0,4353250,"intron",0,0.35,2e-51,50.698970004336,null,0.27,"[0.23-0.31] unit increase","Affymetrix & Illumina [2,593,456] (imputed)","N"]
["V5 (up-regulated)","01/06/2011",21076409,"Sotoodehnia N","11/14/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21076409","Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.","Ventricular conduction","40,407 European ancestry individuals","7,170 European ancestry individuals","5q33.2",5,153869040,"HAND1,SAP30L",null,9421,100131740,null,11.22,69.82,"rs13165478-A","rs13165478",0,13165478,null,1,0.36,7e-14,13.1549019599857,null,0.55,"[0.41-0.69] ms decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (up-regulated)","01/18/2011",20953190,"Strange A","10/17/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20953190","A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.","Psoriasis","2,178 European ancestry cases, 5,175 European ancestry controls","3,174 European ancestry cases, 5,464 European ancestry controls","6q23.3",6,138199417,"TNFAIP3","- ",null,null,7128,null,null,"rs610604-?","rs610604",0,610604,"intron",0,"NR",7e-07,6.15490195998574,null,1.22,"[1.13-1.32] ","Illumina [535,475]","N"]
["V5 (up-regulated)","11/17/2010",20935630,"Speliotes EK","10/10/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20935630","Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.","Body mass index"," (up-regulated) to 123,865 European ancestry individuals"," (up-regulated) to 125,931 European ancestry individuals","16p13.3",16,4038387,"ADCY9","- ",null,null,115,null,null,"rs2444217-A","rs2444217",0,2444217,"intron",0,0.57,9e-08,7.04575749056067,null,"NR","NR","Affymetrix, Illumina and Perlegen [~2.8 million] (imputed)","N"]
["V5 (up-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","18q21.1",18,46959500,"DYM","- ",null,null,54808,null,null,"rs9967417-C","rs9967417",0,9967417,"intron",0,0.58,9e-25,24.0457574905606,null,0.04,"[NR] unit decrease","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V5 (up-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","12q24.31",12,123823546,"SBNO1","- ",null,null,55206,null,null,"rs11830103-A","rs11830103",0,11830103,"intron",0,0.78,4e-15,14.397940008672,null,0.04,"[NR] unit decrease","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V5 (up-regulated)","10/17/2010",20864672,"Waterworth DM","09/23/2010","Arterioscler Thromb Vasc Biol","http://www.ncbi.nlm.nih.gov/pubmed/20864672","Genetic variants influencing circulating lipid levels and risk of coronary artery disease.","Triglycerides"," (up-regulated) to 17,243 white European descent individuals"," (up-regulated) to 37,774 white European descent individuals,  (up-regulated) to 9,665 Indian Asian individuals","7q11.23",7,72856430,"BAZ1B, BCL7B, TBL2, MLXIPL","- ",null,null,9031,null,null,"rs1178979-A","rs1178979",0,1178979,"intron",0,0.8,2e-12,11.698970004336,null,0.05,"[0.03-0.07] unit increase","Affymetrix, Illumina & Perlegen [2,155,369] (imputed)","N"]
["V5 (up-regulated)","07/21/2011",20834067,"Yashin AI","09/01/2010","Aging (Albany NY)","http://www.ncbi.nlm.nih.gov/pubmed/20834067","Joint influence of small-effect genetic variants on human longevity.","Longevity","1,173 individuals","NR","11p15.4",11,3036324,"CARS","- ",null,null,833,null,null,"rs739401-?","rs739401",0,739401,"intron",0,"NR",1e-06,5.99999999999999,"(less than or equal to)","NR","NR","[~550,000]","N"]
["V5 (up-regulated)","09/28/2010",20802025,"Tang W","08/27/2010","Blood","http://www.ncbi.nlm.nih.gov/pubmed/20802025","Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study.","Protein C levels","8,048 European ancestry individuals","1,376 European ancestry individuals","20q11.22",20,33730387,"EDEM2","- ",null,null,55741,null,null,"rs6120849-T","rs6120849",0,6120849,"intron",0,0.23,7e-37,36.1549019599857,null,0.14,"[0.12-0.16] ug/ml decrease","Affymetrix [2,461,269]","N"]
["V5 (up-regulated)","09/28/2010",20802025,"Tang W","08/27/2010","Blood","http://www.ncbi.nlm.nih.gov/pubmed/20802025","Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study.","Protein C levels","8,048 European ancestry individuals","1,376 European ancestry individuals","7q11.23",7,72904810,"BAZ1B","- ",null,null,9031,null,null,"rs17145713-T","rs17145713",0,17145713,"intron",0,0.2,3e-08,7.52287874528033,null,0.06,"[0.04-0.08] ug/ml decrease","Affymetrix [2,461,269]","N"]
["V5 (up-regulated)","09/16/2010",20694014,"Thye T","08/08/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20694014","Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.","Tuberculosis","921 Ghanaian cases 1,740 Ghanaian controls, 1,316 Gambian cases, 1,382 Gambian controls","1,226 Ghanaian cases, 3,825 Ghanaian controls, 236 Malawian cases, 779 Malawian controls, 332 Ghana parent/child trios and duos","18q11.2",18,20190795,"GATA6,CTAGE1,RBBP8,CABLES1",null,646583,646595,null,23.55,289.65,"rs4331426-G","rs4331426",0,4331426,null,1,0.48,7e-09,8.15490195998574,null,1.19,"[1.10-1.30] ","Affymetrix [>333,754] (imputed)","N"]
["V5 (up-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","Cholesterol, total"," (up-regulated) to 100,184 European descent individuals",null,"2q21.3",2,135837906,"RAB3GAP1","- ",null,null,22930,null,null,"rs7570971-T ","rs7570971",0,7570971,"intron",0,0.31,1e-08,8,null,1.18,"[0.75-1.61] mg/dL increase","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V5 (up-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","HDL cholesterol","99,900 European descent individuals",null,"12q24.31",12,123796238,"SBNO1","- ",null,null,55206,null,null,"rs4759375-T","rs4759375",0,4759375,"intron",0,0.06,8e-09,8.09691001300805,null,0.86,"[0.55-1.17] mg/dL increase","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V5 (up-regulated)","09/02/2010",20639880,"Liu X","07/18/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20639880","Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.","Primary biliary cirrhosis","453 Italian cases, 945 Italian controls,","481 Canadian cases, 3,706 Canadian controls","7q32.1",7,128594183,"IRF5,TNPO3","- ",null,null,23534,null,null,"rs10488631-C","rs10488631",0,10488631,"nearGene-3",0,0.11,3e-10,9.52287874528033,null,1.63,"[NR] ","Illumina [276,459]","N"]
["V5 (up-regulated)","06/22/2010",20522523,"Kasperaviciute D","06/03/2010","Brain","http://www.ncbi.nlm.nih.gov/pubmed/20522523","Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.","Partial epilepsies"," (up-regulated) to 3,445 European ancestry cases, 6,935 European ancestry controls","NR","16p13.3",16,4103871,"ADCY9","- ",null,null,115,null,null,"rs2601828-A","rs2601828",0,2601828,"intron",0,0.222,1e-06,5.99999999999999,null,1.12,"[1.12-1.31] ","Illumina [528,745]","N"]
["V5 (up-regulated)","06/13/2010",20453841,"Kochi Y","05/09/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20453841","A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.","Rheumatoid arthritis","2,303 Japanese cases, 3,380 Japanese controls","4,768 Japanese cases, 17,359 Japanese controls","6q23.3",6,138196066,"OLIG3,TNFAIP3","- ",null,null,7128,null,null,"rs2230926-C","rs2230926",0,2230926,"missense",0,0.07,2e-06,5.69897000433601,null,1.31,"[1.17-1.46] ","Illumina [393,217]","N"]
["V5 (up-regulated)","06/13/2010",20453842,"Stahl EA","05/09/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20453842","Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.","Rheumatoid arthritis","5,539 European ancestry cases, 20,169 European ancestry controls","6,768 European ancestry cases, 8,806 European ancestry controls","6q23.3",6,138006504,"TNFAIP3",null,391040,7128,null,140.92,181.82,"rs6920220-A","rs6920220",0,6920220,null,1,0.22,9e-13,12.0457574905606,null,1.22,"[1.16-1.29] ","Affymetrix & Illumina [~2,716,259] (imputed)","N"]
["V5 (up-regulated)","05/05/2010",20383146,"Kottgen A","04/11/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20383146","New loci associated with kidney function and chronic kidney disease.","Chronic kidney disease"," (up-regulated) to 67,093 European ancestry individuals"," (up-regulated) to 22,982 European ancestry individuals","1q21.3",1,150951477,"ANXA9,FAM63A,PRUNE,BNIPL,LASS2,SETDB1",null,29956,8416,null,4,3.02,"rs267734-C","rs267734",0,267734,null,1,0.2,1e-12,12,"(eGFRcrea)",0.01,"[0.004-0.016] ml/min/1.73m2 increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (up-regulated)","05/10/2010",20364137,"Yasuno K","04/04/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20364137","Genome-wide association study of intracranial aneurysm identifies three new risk loci.","Intracranial aneurysm","2,780 European cases, 12,515 European controls","3,111 Japanese cases, 1,666 Japanese controls","18q11.2",18,20223695,"RBBP8",null,646583,646595,null,56.45,256.75,"rs11661542-C","rs11661542",0,11661542,null,1,0.49,1e-12,12,null,1.22,"[1.15-1.28] ","Illumina [831,534] (imputed)","N"]
["V5 (up-regulated)","03/29/2010",20190752,"Dubois PC","02/28/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20190752","Multiple common variants for celiac disease influencing immune gene expression.","Celiac disease","4,533 European descent cases, 10,750 European descent controls","4,918 European descent cases, 5,684 European descent controls","6q23.3",6,137973068,"TNFAIP3",null,391040,7128,null,107.49,215.26,"rs2327832-G","rs2327832",0,2327832,null,1,0.22,4e-19,18.397940008672,null,1.23,"[1.17-1.28] ","Illumina [292,387]","N"]
["V5 (up-regulated)","03/29/2010",20190752,"Dubois PC","02/28/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20190752","Multiple common variants for celiac disease influencing immune gene expression.","Celiac disease","4,533 European descent cases, 10,750 European descent controls","4,918 European descent cases, 5,684 European descent controls","3q13.33",3,119118796,"CD80, KTELC1","- ",null,null,57514,null,null,"rs11712165-C","rs11712165",0,11712165,"intron",0,0.39,8e-09,8.09691001300805,null,1.13,"[1.08-1.17] ","Illumina [292,387]","N"]
["V5 (up-regulated)","03/23/2010",20171287,"Stein JL","02/17/2010","Neuroimage","http://www.ncbi.nlm.nih.gov/pubmed/20171287?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Voxelwise genome-wide association study (vGWAS).","Brain structure","740 Caucasian individuals","NR","16p12.1",16,24531718,"RBBP6",null,10368,5930,null,157.98,19.19,"rs11643520-?","rs11643520",0,11643520,null,1,0.12,6e-07,6.22184874961635,null,"NR","NR","Illumina [448,293]","N"]
["V5 (up-regulated)","12/10/2009",19915576,"Satake W","11/15/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19915576?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.","Parkinson's disease","988 Japanese cases, 2,521 Japanese controls","933 Japanese cases, 15,753 Japanese controls","1q32.1",1,205752665,"PARK16, SLC45A3, NUCKS1, RAB7L1, SLC41A1, PM20D1",null,8934,254428,null,8.06,5.56,"rs947211-?","rs947211",0,947211,null,1,"NR",2e-12,11.698970004336,null,1.3,"[1.21-1.39] ","Illumina [435,470]","N"]
["V5 (up-regulated)","12/04/2009",19893584,"Kim JJ","11/06/2009","J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/19893584","Identification of 15 loci influencing height in a Korean population.","Height","8,842 Korean individuals","NR","8q24.11",8,118827839,"EXT1","- ",null,null,2131,null,null,"rs11989122-T","rs11989122",0,11989122,"intron",0,0.48,6e-06,5.22184874961635,null,0.36,"[NR] cm decrease","Affymetrix [334,546]","N"]
["V5 (up-regulated)","12/04/2009",19893584,"Kim JJ","11/06/2009","J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/19893584","Identification of 15 loci influencing height in a Korean population.","Height","8,842 Korean individuals","NR","12q23.2",12,102513531,"N (up-regulated)37, C12orf48, PMCH","- ",null,null,"55010;79023",null,null,"rs2292303-C","rs2292303",0,2292303,"nearGene-5;nearGene-5",0,0.3,8e-06,5.09691001300805,null,0.51,"[NR] cm decrease","Affymetrix [334,546]","N"]
["V5 (up-regulated)","11/09/2009",19838193,"Han JW","10/18/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19838193?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2","Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic l (up-regulated)us erythematosus.","Systemic l (up-regulated)us erythematosus","1,047 Chinese Han cases, 1,205 Chinese Han controls","3,152 Chinese Han cases, 7,050 Chinese Han controls","6q23.3",6,138196066,"TNFAIP3","- ",null,null,7128,null,null,"rs2230926-C","rs2230926",0,2230926,"missense",0,0.04,1e-17,17,null,1.72,"[1.52-1.94] ","Illumina [493,955]","N"]
["V5 (up-regulated)","11/03/2009",19862010,"Ganesh SK","10/11/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19862010?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.","Mean corpuscular hemoglobin","24,167 European ancestry individuals","9,456 European ancestry individuals","3q29",3,195809139,"TFRC","- ",null,null,7037,null,null,"rs11915082-A","rs11915082",0,11915082,"nearGene-5",0,"NR",8e-13,12.096910013008,null,0,"[0.003-0.005] pg increase","Affymetrix & Illumina [~2.5 million](imputed)","N"]
["V5 (up-regulated)","11/03/2009",19862010,"Ganesh SK","10/11/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19862010?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.","Mean corpuscular volume","24,167 European ancestry individuals","9,456 European ancestry individuals","3q29",3,195800547,"TFRC","- ",null,null,7037,null,null,"rs9859260-C","rs9859260",0,9859260,"intron",0,"NR",8e-14,13.096910013008,null,0,"[0.002-0.004] fl increase","Affymetrix & Illumina [~2.5 million](imputed)","N"]
["V5 (up-regulated)","07/13/2009",19578365,"Falchi M","07/05/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19578365","Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi.","Cutaneous nevi","1,524 European ancestry twins","4,107 European ancestry individuals","9p21.3",9,21747803,"MTAP",null,402359,100418937,null,47.73,63.85,"rs4636294-A","rs4636294",0,4636294,null,1,0.48,3e-15,14.5228787452803,null,0.2,"[0.13-0.27] increase in log nevus count","Illumina [297,108]","N"]
["V5 (up-regulated)","07/13/2009",19571811,"Purcell SM","07/01/2009","Nature","http://www.ncbi.nlm.nih.gov/pubmed/19571811","Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.","Schizophrenia","3,322 European ancestry cases, 3,587 European ancestry controls","4,692 European ancestry cases, 15,493 European ancestry controls","3q26.33",3,180550702,"FXR1",null,100130898,391595,null,3.07,54.76,"rs6782299-T","rs6782299",0,6782299,null,1,0.73,1e-07,7,null,1.1,null,"Affymetrix [739,995]","N"]
["V5 (up-regulated)","06/30/2009",19525955,"Bahlo","06/14/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19525955?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.","Multiple sclerosis","1,618 European ancestry cases, 3,413 European ancestry controls","2,256 European ancestry cases, 2,310 European ancestry controls","12q14.1",12,58162739,"METTL1, CYP27B1","- ",null,null,"1594;4234",null,null,"rs703842-A","rs703842",0,703842,"nearGene-5;UTR-3",0,0.67,5e-11,10.3010299956639,null,1.23,"[NR] ","Illumina [302,098]","N"]
["V5 (up-regulated)","03/01/2009",19198612,"Erdmann J","02/08/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19198612?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","New susceptibility locus for coronary artery disease on chromosome 3q22.3.","Coronary heart disease","6,990 cases, 8,955 controls","12,417 cases, 12,411 controls","12q24.31",12,121435587,"HNF1A,C12orf43","- ",null,null,6927,null,null,"rs2259816-T","rs2259816",0,2259816,"intron",0,0.36,5e-07,6.30102999566398,null,1.08,"[1.05-1.11] ","Affymetrix [567,119]","N"]
["V5 (up-regulated)","02/06/2009",19169254,"Nair RP","01/25/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19169254?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.","Psoriasis","1,359 cases, 1,400 controls","5,048 cases, 5,041 controls","9q34.13",9,135776034,"TSC1","- ",null,null,7248,null,null,"rs1076160-T","rs1076160",0,1076160,"intron",0,0.48,6e-06,5.22184874961635,null,1.09,"[NR] ","Perlegen [~2.5 million] (imputed)","N"]
["V5 (up-regulated)","02/06/2009",19169254,"Nair RP","01/25/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19169254?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.","Psoriasis","1,359 cases, 1,400 controls","5,048 cases, 5,041 controls","6q23.3",6,138199417,"TNFAIP3","- ",null,null,7128,null,null,"rs610604-G","rs610604",0,610604,"intron",0,0.32,9e-12,11.0457574905606,null,1.19,"[NR] ","Perlegen [~2.5 million] (imputed)","N"]
["V5 (up-regulated)","03/03/2009",19151714,"Meyre D","01/18/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19151714?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.","Obesity","695 obese adults, 685 obese children, 731 lean adults, 685 lean children","1,171 obese adults, 896 obese children, 1,114 lean adults, 1,297 lean children, 4,417 adults, 5,291 children","18q11.2",18,21140432,"NPC1","- ",null,null,4864,null,null,"rs1805081-A","rs1805081",0,1805081,"missense",0,0.56,3e-07,6.52287874528033,"(children)",1.33,"[1.08-1.75] ","Illumina [308,846]","N"]
["V5 (up-regulated)","01/16/2009",19010793,"Baranzini SE","11/14/2008","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19010793?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.","Normalized brain volume","753 cases,883 controls","NR","10p11.23",10,30008663,"SVIL","- ",null,null,6840,null,null,"rs1927457-?","rs1927457",0,1927457,"intron",0,0.31,8e-06,5.09691001300805,null,"NR","NR","Illumina[551,642]","N"]
["V5 (up-regulated)","12/01/2008",18940312,"Yuan X","10/10/2008","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/18940312","Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.","Liver enzyme levels","7,751 European ancestry individuals","4,704 European ancestry and Asian Indian individuals","10q24.2",10,101861435,"CPN1, CHUK, ERLIN1",null,1369,10613,null,19.79,48.41,"rs11597390-A","rs11597390",0,11597390,null,1,0.36,2e-08,7.69897000433601,"(ALT)",0.04,"[0.025-0.053] U/L decrease","Affymetrix and Illumina[ (up-regulated) to 496,032]","N"]
["V5 (up-regulated)","12/01/2008",18940312,"Yuan X","10/10/2008","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/18940312","Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.","Liver enzyme levels","7,751 European ancestry individuals","4,704 European ancestry and Asian Indian individuals","12q24.31",12,121442670,"HNF1A, C12orf27, C12orf43","- ",null,null,64897,null,null,"rs1169313-C","rs1169313",0,1169313,"intron",0,0.38,2e-10,9.69897000433601,"(GGT)",0.01,"[0.003-0.007] U/L decrease","Affymetrix and Illumina[ (up-regulated) to 496,032]","N"]
["V5 (up-regulated)","11/25/2008",18820697,"Miyagawa T","09/28/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18820697","Variant between CPT1B and CHKB associated with susceptibility to narcolepsy.","Narcolepsy","222 Japanese ancestry cases,389 Japanese ancestry controls","748 cases,994 controls","22q13.33",22,51017353,"CPT1B","- ",null,null,"1120;1375;386593",null,null,"rs5770917-C","rs5770917",0,5770917,"nearGene-3;nearGene-5;intron",0,0.17,6e-08,7.22184874961635,null,1.63,"[1.37-1.95] ","Affymetrix[249,133]","N"]
["V5 (up-regulated)","11/25/2008",18780872,"Liu P","09/17/2008","J Natl Cancer Inst","http://www.ncbi.nlm.nih.gov/pubmed/18780872?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer.","Lung cancer","194 cases,219 controls","3,878 cases,4,831 controls","15q25.1",15,78806023,"LOC123688, PSMA4, CHRNA3, CHRNA5, CHRNB4","- ",null,null,123688,null,null,"rs8034191-G","rs8034191",0,8034191,"intron",0,"NR",1e-08,8,null,1.38,"[1.17-1.64] ","Affymetrix[ (up-regulated) to 722,376]","N"]
["V5 (up-regulated)","11/25/2008",19165918,"Graham RR","08/01/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19165918","Genetic variants near TNFAIP3 on 6q23 are associated with systemic l (up-regulated)us erythematosus.","Systemic l (up-regulated)us erythematosus","431 cases,2,155 controls","740 trios","6q23.3",6,138195723,"TNFAIP3","- ",null,null,7128,null,null,"rs5029939-?","rs5029939",0,5029939,"intron",0,0.03,3e-12,11.5228787452803,null,2.28,"[NR] ","Affymetrix[313,238]","N"]
["V5 (up-regulated)","11/25/2008",18391951,"Gudbjartsson DF","04/06/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18391951?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Many sequence variants affecting diversity of adult human height.","Height","30,968 individuals","8,541 individuals","12q15",12,69828681,"LYZ,YEATS4,FRS2,CPSF6,CCT2,LRRC10",null,100271570,10818,null,11.91,35.45,"rs11177669-A","rs11177669",0,11177669,null,1,0.31,3e-06,5.52287874528033,null,4.5,"[2.54-6.46] % s.d. taller","Illumina and Affymetrix[ (up-regulated) to 304,226]","N"]
["V5 (up-regulated)","11/25/2008",18391951,"Gudbjartsson DF","04/06/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18391951?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Many sequence variants affecting diversity of adult human height.","Height","30,968 individuals","8,541 individuals","17q11.2",17,29247715,"CRLF3, ATAD5, CENTA2, RNF135","- ",null,null,55803,null,null,"rs3760318-C","rs3760318",0,3760318,"nearGene-5",0,0.63,2e-09,8.69897000433601,null,6,"[4.04-7.96] % s.d. taller","Illumina and Affymetrix[ (up-regulated) to 304,226]","N"]
["V5 (up-regulated)","11/25/2008",18391951,"Gudbjartsson DF","04/06/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18391951?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Many sequence variants affecting diversity of adult human height.","Height","30,968 individuals","8,541 individuals","18q11.2",18,20724328,"CABLES1, RBBP8, C18orf45","- ",null,null,91768,null,null,"rs4800148-A","rs4800148",0,4800148,"intron",0,0.79,4e-09,8.39794000867203,null,6.4,"[4.24-8.56] % s.d. taller","Illumina and Affymetrix[ (up-regulated) to 304,226]","N"]
["V5 (up-regulated)","11/25/2008",18391952,"Weedon MN","04/06/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18391952?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genome-wide association analysis identifies 20 loci that influence adult height.","Height","13,665 individuals","16,482 individuals","18q21.1",18,46991160,"DYM",null,54808,497661,null,4.08,16.39,"rs8099594-A","rs8099594",0,8099594,null,1,0.65,3e-07,6.52287874528033,null,0.05,"[0.02-0.08] s.d. taller - among males","Affymetrix[402,951]","N"]
["V5 (up-regulated)","11/25/2008",18385676,"Amos CI","04/03/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18385676?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.","Lung cancer","1,154 cases,1,137 controls","2,724 cases,3,694 controls","15q25.1",15,78806023,"CHRNA3, CHRNA5, PSMA4, LOC123688","- ",null,null,123688,null,null,"rs8034191-G","rs8034191",0,8034191,"intron",0,"NR",3e-18,17.5228787452803,null,1.3,"[1.15-1.47] ","Illumina[317,498]","N"]
["V5 (up-regulated)","11/25/2008",18385738,"Hung RJ","04/03/2008","Nature","http://www.ncbi.nlm.nih.gov/pubmed/18385738?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.","Lung cancer","1,926 cases,2,522 controls","2,513 cases,4,752 controls","15q25.1",15,78806023,"CHRNA3,CHRNA5, CHRNB4, PSMA4, LOC123688","- ",null,null,123688,null,null,"rs8034191-C","rs8034191",0,8034191,"intron",0,0.34,5e-20,19.3010299956639,null,1.3,"[1.23-1.37] ","Illumina[310,023]","N"]
["V5 (up-regulated)","11/25/2008",18204446,"Harley JB","01/20/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18204446?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genome-wide association scan in women with systemic l (up-regulated)us erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.","Systemic l (up-regulated)us erythematosus","720 female cases,2,337 female controls","1,846 female cases,1,825 female controls","7q32.1",7,128717906,"IRF5, TNPO3",null,286016,349158,null,20.61,39.66,"rs12537284-A","rs12537284",0,12537284,null,1,0.13,4e-19,18.397940008672,null,1.54,"[1.40-1.70] ","Illumina [317,501]","N"]
["V5 (up-regulated)","11/25/2008",18204098,"Hom G","01/20/2008","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/18204098?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Association of systemic l (up-regulated)us erythematosus with C8orf13-BLK and ITGAM-ITGAX.","Systemic l (up-regulated)us erythematosus","1,311 cases,3,340 controls","793 cases,857 controls","7q32.1",7,128594183,"IRF5, TNPO3","- ",null,null,23534,null,null,"rs10488631-C","rs10488631",0,10488631,"nearGene-3",0,0.12,2e-11,10.698970004336,null,"NR","NR","Illumina[502,033]","N"]
["V5 (up-regulated)","11/25/2008",17982456,"Plenge RM","11/04/2007","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/17982456?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.","Rheumatoid arthritis","397 cases,1,211 Framingham individuals","2,283 cases,3,258 controls","6q23.3",6,138002637,"TNFAIP3, OLIG3",null,391040,7128,null,137.06,185.69,"rs10499194-C","rs10499194",0,10499194,null,1,0.71,1e-09,8.99999999999999,null,1.33,"[1.15-1.52] ","Affymetrix[79,853]","N"]
["V5 (up-regulated)","11/25/2008",17982456,"Plenge RM","11/04/2007","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/17982456?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.","Rheumatoid arthritis","397 cases,1,211 Framingham individuals","2,283 cases,3,258 controls","6q23.3",6,138006504,"TNFAIP3, OLIG3",null,391040,7128,null,140.92,181.82,"rs6920220-?","rs6920220",0,6920220,null,1,0.2,1e-07,7,null,1.22,"[NR] ","Affymetrix[79,853]","N"]
["V5 (up-regulated)","11/25/2008",17903293,"Benjamin EJ","09/19/2007","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/17903293?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genome-wide association with select biomarker traits in the Framingham Heart Study.","Select biomarker traits","1,012 individuals(Framingham)","NR","10q26.2",10,129933456,"PTPRE, MKI67",null,4288,4255,null,8.99,1332,"rs2387326-?","rs2387326",0,2387326,null,1,"NR",1e-06,5.99999999999999,"(VitKPhylloq)","NR","NR","Affymetrix[70,897]","N"]
["V5 (up-regulated)","11/25/2008",17554300,"WTCCC","06/07/2007","Nature","http://www.ncbi.nlm.nih.gov/pubmed/17554300","Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.","Bipolar disorder","1,868 cases,2,938 controls","NR","16p12.2",16,23634026,"PALB2,NDUFAB1,DCTN5","- ",null,null,79728,null,null,"rs420259-A","rs420259",0,420259,"intron",0,0.72,6e-08,7.22184874961635,null,2.08,"[1.60-2.71] ","Affymetrix [469,557]","N"]
["V5 (down-regulated)","06/26/2013",23535033,"Sherva R","03/24/2013","Alzheimers Dement","http://www.ncbi.nlm.nih.gov/pubmed/23535033","Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.","Alzheimer's disease (cognitive decline)","303 European ancestry cases",null,"12q22",12,94235165,"CRADD","- ",null,null,8738,null,null,"rs61144803-?","rs61144803",0,61144803,"intron",0,0.04,5e-08,7.30102999566398,null,0.16,"unit decrease","Illumina [NR] (Imputed)","N"]
["V5 (down-regulated)","06/26/2013",23535033,"Sherva R","03/24/2013","Alzheimers Dement","http://www.ncbi.nlm.nih.gov/pubmed/23535033","Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.","Alzheimer's disease (cognitive decline)","303 European ancestry cases",null,"4p16.2",4,5237153,"STK32B","- ",null,null,55351,null,null,"rs78647349-?","rs78647349",0,78647349,"intron",0,0.04,5e-07,6.30102999566398,null,0.3,"unit decrease","Illumina [NR] (Imputed)","N"]
["V5 (down-regulated)","06/20/2013",23472165,"Albertsen HM","03/05/2013","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23472165","Genome-wide association study link novel loci to endometriosis.","Endometriosis","1,514 European ancestry casses, 12,660 European ancestry controls","505 European ancestry cases, 1,811 European ancestry controls","6p22.3",6,19803768,"RNF144B , ID4","- ",null,null,100506885,null,null,"rs6907340-A","rs6907340",0,6907340,"ncRNA",0,0.371,2e-07,6.69897000433601,null,1.2,"[1.12-1.28] ","Illumina [580,699]","N"]
["V5 (down-regulated)","06/20/2013",23472165,"Albertsen HM","03/05/2013","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23472165","Genome-wide association study link novel loci to endometriosis.","Endometriosis","1,514 European ancestry casses, 12,660 European ancestry controls","505 European ancestry cases, 1,811 European ancestry controls","2q23.3",2,151635832,"RND3 , RBM43",null,390,344332,null,291.62,406.84,"rs6757804-G","rs6757804",0,6757804,null,1,0.401,6e-08,7.22184874961635,null,1.2,"[1.13-1.29] ","Illumina [580,699]","N"]
["V5 (down-regulated)","06/28/2013",23446634,"Chen Z","02/26/2013","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23446634","Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.","Red blood cell traits"," (up-regulated) to 16,485 African American individuals","9,692 African American individuals, 21,020 European ancestry individuals, 14,088 Japanese ancestry individuals","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-A","rs1800562",0,1800562,"missense",0,0.0151,4e-06,5.39794000867203,"(Hgb, AA)",0.24,"[0.14-0.34] g/dL increase","Affymetrix & Illumina [NR]","N"]
["V5 (down-regulated)","06/28/2013",23446634,"Chen Z","02/26/2013","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23446634","Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.","Red blood cell traits"," (up-regulated) to 16,485 African American individuals","9,692 African American individuals, 21,020 European ancestry individuals, 14,088 Japanese ancestry individuals","2p21",2,46355848,"PRKCE","- ",null,null,5581,null,null,"rs13008603-A","rs13008603",0,13008603,"intron",0,0.163,4e-09,8.39794000867203,"(Ht, AA)",0.28,"[0.18-0.37] % decrease","Affymetrix & Illumina [NR]","N"]
["V5 (down-regulated)","05/21/2013",23437003,"Paternoster L","02/21/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23437003","Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure.","Bone mineral density"," (up-regulated) to 5,878 European ancestry individuals"," (up-regulated) to 1,052 European ancestry individuals","6q25.1",6,151895456,"C6orf97, ESR1","- ",null,null,80129,null,null,"rs6909279-G","rs6909279",0,6909279,"intron",0,0.4,1e-09,8.99999999999999,"(Cortical vBMD)",0.09,"[0.070-0.110] unit decrease","Illumina [2,401,124] (Imputed)","N"]
["V5 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"22q13.1",22,39859169,"SYNGR1,TAB1,MGAT3,CACNA1I","- ",null,null,4248,null,null,"rs909674-C","rs909674",0,909674,"intron",0,0.298476014725569,9e-24,23.0457574905606,"(IGP39)",0.34,"[0.27-0.4] unit increase","Illumina [~2.5 Million] (Imputed)","N"]
["V5 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"22q13.1",22,39859169,"SYNGR1,TAB1,MGAT3,CACNA1I","- ",null,null,4248,null,null,"rs909674-C","rs909674",0,909674,"intron",0,0.298878222915738,2e-10,9.69897000433601,"(IGP34)",0.21,"[0.15-0.28] unit increase","Illumina [~2.5 Million] (Imputed)","N"]
["V5 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"22q13.1",22,39859169,"SYNGR1,TAB1,MGAT3,CACNA1I","- ",null,null,4248,null,null,"rs909674-C","rs909674",0,909674,"intron",0,0.299056983073497,3e-09,8.52287874528033,"(IGP9)",0.2,"[0.13-0.27] unit increase","Illumina [~2.5 Million] (Imputed)","N"]
["V5 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"22q13.1",22,39859169,"SYNGR1,TAB1,MGAT3,CACNA1I","- ",null,null,4248,null,null,"rs909674-C","rs909674",0,909674,"intron",0,0.299013119715176,6e-16,15.2218487496163,"(IGP71)",0.27,"[0.21-0.34] unit increase","Illumina [~2.5 Million] (Imputed)","N"]
["V5 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"22q13.1",22,39859169,"SYNGR1,TAB1,MGAT3,CACNA1I","- ",null,null,4248,null,null,"rs909674-C","rs909674",0,909674,"intron",0,0.299100489968792,2e-06,5.69897000433601,"(IGP30)",0.16,"[0.095-0.227] unit decrease","Illumina [~2.5 Million] (Imputed)","N"]
["V5 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"22q13.1",22,39859169,"SYNGR1,TAB1,MGAT3,CACNA1I","- ",null,null,4248,null,null,"rs909674-C","rs909674",0,909674,"intron",0,0.299323467231387,9e-06,5.04575749056067,"(IGP69)",0.15,"[0.084-0.218] unit increase","Illumina [~2.5 Million] (Imputed)","N"]
["V5 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"22q13.1",22,39859169,"SYNGR1,TAB1,MGAT3,CACNA1I","- ",null,null,4248,null,null,"rs909674-C","rs909674",0,909674,"intron",0,0.299013119715176,1e-16,16,"(IGP66)",0.28,"[0.21-0.35] unit increase","Illumina [~2.5 Million] (Imputed)","N"]
["V5 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"22q13.1",22,39859169,"SYNGR1,TAB1,MGAT3,CACNA1I","- ",null,null,4248,null,null,"rs909674-C","rs909674",0,909674,"intron",0,0.298923567230632,5e-10,9.30102999566398,"(IGP22)",0.21,"[0.14-0.28] unit decrease","Illumina [~2.5 Million] (Imputed)","N"]
["V5 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"22q13.1",22,39859169,"SYNGR1,TAB1,MGAT3,CACNA1I","- ",null,null,4248,null,null,"rs909674-C","rs909674",0,909674,"intron",0,0.299146468388246,2e-10,9.69897000433601,"(IGP62)",0.21,"[0.15-0.28] unit decrease","Illumina [~2.5 Million] (Imputed)","N"]
["V5 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"22q13.1",22,39859169,"SYNGR1,TAB1,MGAT3,CACNA1I","- ",null,null,4248,null,null,"rs909674-C","rs909674",0,909674,"intron",0,0.299013119715176,3e-08,7.52287874528033,"(IGP64)",0.19,"[0.12-0.25] unit decrease","Illumina [~2.5 Million] (Imputed)","N"]
["V5 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"22q13.1",22,39859169,"SYNGR1,TAB1,MGAT3,CACNA1I","- ",null,null,4248,null,null,"rs909674-C","rs909674",0,909674,"intron",0,0.299056983073497,3e-09,8.52287874528033,"(IGP49)",0.2,"[0.13-0.27] unit increase","Illumina [~2.5 Million] (Imputed)","N"]
["V5 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"22q13.1",22,39859169,"SYNGR1,TAB1,MGAT3,CACNA1I","- ",null,null,4248,null,null,"rs909674-C","rs909674",0,909674,"intron",0,0.298923567230632,1e-10,10,"(IGP5)",0.22,"[0.15-0.28] unit increase","Illumina [~2.5 Million] (Imputed)","N"]
["V5 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"22q13.1",22,39859169,"SYNGR1,TAB1,MGAT3,CACNA1I","- ",null,null,4248,null,null,"rs909674-C","rs909674",0,909674,"intron",0,0.299013119715176,3e-13,12.5228787452803,"(IGP45)",0.25,"[0.18-0.31] unit increase","Illumina [~2.5 Million] (Imputed)","N"]
["V5 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"22q13.1",22,39859169,"SYNGR1,TAB1,MGAT3,CACNA1I","- ",null,null,4248,null,null,"rs909674-C","rs909674",0,909674,"intron",0,0.298923976402493,6e-10,9.22184874961635,"(IGP68)",0.21,"[0.14-0.28] unit increase","Illumina [~2.5 Million] (Imputed)","N"]
["V5 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"22q13.1",22,39859169,"SYNGR1,TAB1,MGAT3,CACNA1I","- ",null,null,4248,null,null,"rs909674-C","rs909674",0,909674,"intron",0,0.299146275601069,2e-15,14.698970004336,"(IGP72)",0.27,"[0.2-0.34] unit decrease","Illumina [~2.5 Million] (Imputed)","N"]
["V5 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","1,848 European ancestry individuals",null,"22q13.1",22,39859169,"SYNGR1, TAB1, MGAT3, CACNA1I","- ",null,null,4248,null,null,"rs909674-C","rs909674",0,909674,"intron",0,0.29096,3e-08,7.52287874528033,"(IgG1G0N)",0.08,"[0.054-0.112] unit increase","Illumina [~ 2.5 Million] (Imputed)","N"]
["V5 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","1,848 European ancestry individuals",null,"22q13.1",22,39859169,"SYNGR1, TAB1, MGAT3, CACNA1I","- ",null,null,4248,null,null,"rs909674-C","rs909674",0,909674,"intron",0,0.29096,2e-10,9.69897000433601,"(IgG1G1N)",0.07,"[0.050-0.094] unit increase","Illumina [~ 2.5 Million] (Imputed)","N"]
["V5 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","1,848 European ancestry individuals",null,"22q13.1",22,39859169,"SYNGR1, TAB1, MGAT3, CACNA1I","- ",null,null,4248,null,null,"rs909674-C","rs909674",0,909674,"intron",0,0.29096,9e-06,5.04575749056067,"(IgG1G2N)",0.07,"[0.036-0.094] unit increase","Illumina [~ 2.5 Million] (Imputed)","N"]
["V5 (down-regulated)","06/14/2013",23382691,"Lauc G","01/31/2013","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23382691 ","Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.","IgG glycosylation","2,247 European ancestry individuals",null,"22q13.1",22,39859169,"SYNGR1,TAB1,MGAT3,CACNA1I","- ",null,null,4248,null,null,"rs909674-C","rs909674",0,909674,"intron",0,0.299013119715176,1e-24,24,"(IGP40)",0.34,"[0.28-0.41] unit increase","Illumina [~2.5 Million] (Imputed)","N"]
["V5 (down-regulated)","06/06/2013",23362303,"Wu JH","01/29/2013","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/23362303 ","Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.","Palmitoleic acid (16:1n-7) plasma levels","8,961 European ancestry individuals",null,"1p22.1",1,94533014,"ABCA4 ","- ",null,null,24,null,null,"rs1931575-T ","rs1931575 ",0,1931575,"intron",0,"NR ",2e-06,5.69897000433601,null,0.02,"unit increase ","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","05/10/2013",23322567,"Lopes MC","01/15/2013","Invest Ophthalmol Vis Sci","http://www.ncbi.nlm.nih.gov/pubmed/23322567","Identification of a candidate gene for astigmatism.","Corneal astigmatism","22,100 European ancestry individuals",null,"2p13.3",2,71133014,"VAX2","- ",null,null,25806,null,null,"rs3771395-G","rs3771395",0,3771395,"intron",0,0.16,2e-07,6.69897000433601,null,0.08,"[NR] unit decrease","Illumina & Affymetrix [2.8 million] (Imputed)","N"]
["V5 (down-regulated)","04/04/2013",23319000,"Luykx JJ","01/15/2013","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23319000 ","Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.","Metabolite levels (5-HIAA)"," (up-regulated) to 398 European individuals","NR","16q23.1",16,78335044,"WWOX","- ",null,null,51741,null,null,"rs78867184-G","rs78867184",0,78867184,"intron",0,"NR",9e-06,5.04575749056067,null,0.21,"unit increase","Illumina [5,767,231] (Imputed)","N"]
["V5 (down-regulated)","04/04/2013",23319000,"Luykx JJ","01/15/2013","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23319000 ","Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.","Metabolite levels (HVA)"," (up-regulated) to 398 European individuals","NR","8p12",8,29106059,"KIF13B","- ",null,null,23303,null,null,"rs2954793-T","rs2954793",0,2954793,"intron",0,"NR",3e-06,5.52287874528033,null,0.23,"unit increase","Illumina [5,767,231] (Imputed)","N"]
["V5 (down-regulated)","04/04/2013",23319000,"Luykx JJ","01/15/2013","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23319000 ","Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.","Metabolite levels (HVA-5-HIAA Factor score)"," (up-regulated) to 398 European individuals","NR","8p12",8,28995022,"KIF13B, AF086219","- ",null,null,23303,null,null,"rs13251954-A","rs13251954",0,13251954,"intron",0,"NR",2e-06,5.69897000433601,null,0.24,"unit decrease","Illumina [5,767,231] (Imputed)","N"]
["V5 (down-regulated)","03/27/2013",23300278,"Saxena R","01/08/2013","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/23300278 ","Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.","Type 2 diabetes","842 Punjabi Sikh cases, 774 Punjabi Sikh controls"," (up-regulated) to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls;  (up-regulated) to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls;  (up-regulated) to 13,559 other South Asian cases and 20,822 other South Asian controls;  (up-regulated) to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls;  (up-regulated) to 8,130 European ancestry cases and 38,987 European ancestry controls","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-T","rs7903146",0,7903146,"intron",0,0.31,3e-19,18.5228787452803,"(Punjabi Sikhs)",1.44,"[1.33 - 1.56] ","Illumina [1,232,008] (imputed)","N"]
["V5 (down-regulated)","03/27/2013",23300278,"Saxena R","01/08/2013","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/23300278 ","Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.","Type 2 diabetes","842 Punjabi Sikh cases, 774 Punjabi Sikh controls"," (up-regulated) to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls;  (up-regulated) to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls;  (up-regulated) to 13,559 other South Asian cases and 20,822 other South Asian controls;  (up-regulated) to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls;  (up-regulated) to 8,130 European ancestry cases and 38,987 European ancestry controls","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-T","rs7903146",0,7903146,"intron",0,0.31,6e-22,21.2218487496163,"(All Punjabi)",1.3,"[1.23 - 1.37] ","Illumina [1,232,008] (imputed)","N"]
["V5 (down-regulated)","03/27/2013",23300278,"Saxena R","01/08/2013","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/23300278 ","Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.","Type 2 diabetes","842 Punjabi Sikh cases, 774 Punjabi Sikh controls"," (up-regulated) to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls;  (up-regulated) to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls;  (up-regulated) to 13,559 other South Asian cases and 20,822 other South Asian controls;  (up-regulated) to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls;  (up-regulated) to 8,130 European ancestry cases and 38,987 European ancestry controls","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-T","rs7903146",0,7903146,"intron",0,0.3,3e-35,34.5228787452803,"(South Asians)",1.15,"[1.13 - 1.18] ","Illumina [1,232,008] (imputed)","N"]
["V5 (down-regulated)","03/27/2013",23300278,"Saxena R","01/08/2013","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/23300278 ","Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.","Type 2 diabetes","842 Punjabi Sikh cases, 774 Punjabi Sikh controls"," (up-regulated) to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls;  (up-regulated) to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls;  (up-regulated) to 13,559 other South Asian cases and 20,822 other South Asian controls;  (up-regulated) to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls;  (up-regulated) to 8,130 European ancestry cases and 38,987 European ancestry controls","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-T","rs7903146",0,7903146,"intron",0,0.3,2e-38,37.698970004336,"(South Asians, East Asians)",1.15,"[1.12 - 1.17] ","Illumina [1,232,008] (imputed)","N"]
["V5 (down-regulated)","03/27/2013",23300278,"Saxena R","01/08/2013","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/23300278 ","Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.","Type 2 diabetes","842 Punjabi Sikh cases, 774 Punjabi Sikh controls"," (up-regulated) to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls;  (up-regulated) to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls;  (up-regulated) to 13,559 other South Asian cases and 20,822 other South Asian controls;  (up-regulated) to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls;  (up-regulated) to 8,130 European ancestry cases and 38,987 European ancestry controls","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-T","rs7903146",0,7903146,"intron",0,0.5,9e-75,74.0457574905606,"(South Asian, East Asian, Europeans)",1.19,"[1.17 - 1.21] ","Illumina [1,232,008] (imputed)","N"]
["V5 (down-regulated)","02/21/2013",23273568,"Yang W","12/27/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/23273568","Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic l (up-regulated)us erythematosus in Asians.","Systemic l (up-regulated)us erythematosus","1,656 Han Chinese cases, 3,394 Han Chinese controls","3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls","11q24.3",11,128311059,"ETS1",null,283165,2113,null,1435.11,17.6,"rs6590330-A","rs6590330",0,6590330,null,1,0.35,3e-08,7.52287874528033,null,1.51,null,"Illumina [2,100,739] (imputed)","N"]
["V5 (down-regulated)","03/15/2013",23263486,"Kottgen A","12/23/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263486","Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.","Urate levels","49,825 European ancestry men, 60,522 European ancestry women"," (up-regulated) to 32,813 European ancestry individuals","12q13.13",12,52251272,"ACVR1B, ACVRL1",null,401720,341405,null,25.57,30.52,"rs7976059-T","rs7976059",0,7976059,null,1,0.35,2e-09,8.69897000433601,"(network)",0.03,"[0.022-0.042] mg/dl increase","Affymetrix, Illumina, Perlegen [2,450,547] (imputed)","N"]
["V5 (down-regulated)","02/26/2013",23259602,"Wang X","12/21/2012","BMC Oral Health","http://www.ncbi.nlm.nih.gov/pubmed/23259602","Genome-wide association scan of dental caries in the permanent dentition.","Dental caries","1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals",null,"8p21.3",8,20301437,"LZTS1",null,11178,26844,null,188.63,170.93,"rs4922199-?","rs4922199",0,4922199,null,1,"NR",8e-06,5.09691001300805,"(Comparatively Younger)","NR","NR","Illumina and Affymetrix [~ 1.4 Million] (imputed)","N"]
["V5 (down-regulated)","02/26/2013",23259602,"Wang X","12/21/2012","BMC Oral Health","http://www.ncbi.nlm.nih.gov/pubmed/23259602","Genome-wide association scan of dental caries in the permanent dentition.","Dental caries","1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals",null,"6q27",6,167177422,"RPS6KA2","- ",null,null,6196,null,null,"rs635808-?","rs635808",0,635808,"intron",0,"NR",1e-07,7,"(Comparatively Younger)","NR","NR","Illumina and Affymetrix [~ 1.4 Million] (imputed)","N"]
["V5 (down-regulated)","02/27/2013",23266558,"Yamazaki K","12/21/2012","Gastroenterology","http://www.ncbi.nlm.nih.gov/pubmed/23266558","A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.","Crohn's disease","372 Japanese ancestry cases and 3,389 Japanese ancestry controls"," (up-regulated) to 1,151 Japanese ancestry cases and  (up-regulated) to 15,800 Japanese ancestry controls","9q32",9,117545666,"TNFSF15, LOC100129633, LOC645266, TNFSF8",null,203197,9966,null,136.96,1.25,"rs6478106-T","rs6478106",0,6478106,null,1,"NR",5e-46,45.3010299956639,null,1.73,"[1.60-1.86] ","Illumina [4,929,034] (imputed)","N"]
["V5 (down-regulated)","02/27/2013",23284291,"Hancock DB","12/20/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23284291 ","Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.","Pulmonary function (interaction)","50,047 European ancestry individuals","NR","2q35",2,218683154,"TNS1","- ",null,null,7145,null,null,"rs2571445-?","rs2571445",0,2571445,"missense",0,"NR",8e-09,8.09691001300805,"(FEV1, Ever-smoking)","NR","NR","NR [~2.5 Million] (imputed)","N"]
["V5 (down-regulated)","02/27/2013",23284291,"Hancock DB","12/20/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23284291 ","Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.","Pulmonary function (interaction)","50,047 European ancestry individuals","NR","3p24.2",3,25520582,"RARB","- ",null,null,5915,null,null,"rs1529672-?","rs1529672",0,1529672,"intron",0,"NR",7e-11,10.1549019599857,"(FEV1/FVC, Pack-years)","NR","NR","NR [~2.5 Million] (imputed)","N"]
["V5 (down-regulated)","02/27/2013",23284291,"Hancock DB","12/20/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23284291 ","Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.","Pulmonary function (interaction)","50,047 European ancestry individuals","NR","16q23.1",16,78188496,"WWOX","- ",null,null,51741,null,null,"rs8056446-A ","rs8056446   ",0,8056446,"intron",0,"NR",8e-08,7.09691001300805,"(FEV1, Pack-years ","NR","NR","NR [~2.5 Million] (imputed)","N"]
["V5 (down-regulated)","02/27/2013",23284291,"Hancock DB","12/20/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/23284291 ","Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.","Pulmonary function (interaction)","50,047 European ancestry individuals","NR","16q23.1",16,78187903,"WWOX","- ",null,null,51741,null,null,"rs12716850-A ","rs12716850   ",0,12716850,"intron",0,"NR",1e-07,7,"(FEV1, Ever-smoking)","NR","NR","NR [~2.5 Million] (imputed)","N"]
["V5 (down-regulated)","03/15/2013",23263863,"Li J","12/20/2012","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263863","GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.","Hematology traits","7,943 African American children, 6,234 European ancestry children","NR","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-A","rs1800562",0,1800562,"missense",0,"NR",2e-06,5.69897000433601,"(HGB)",0.19,"[0.11-0.27] unit increase","Illumina [544,917]","N"]
["V5 (down-regulated)","03/20/2013",23263863,"Li J","12/20/2012","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23263863","GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.","Mean corpuscular hemoglobin","7,943 African American children, 6,234 European ancestry children","NR","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-A","rs1800562",0,1800562,"missense",0,"NR",7e-09,8.15490195998574,null,0.36,"[0.24-0.48] unit increase","Illumina [544,917]","N"]
["V5 (down-regulated)","03/19/2013",23222517,"van der Harst P","12/05/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23222517","Seventy-five genetic loci influencing the human red blood cell.","Red blood cell traits","62,553 European ancestry individuals, 9,308 South Asian ancestry individuals","63,506 European ancestry individuals","2p21",2,46355051,"PRKCE","- ",null,null,5581,null,null,"rs4953318-A","rs4953318",0,4953318,"intron",0,0.62,3e-19,18.5228787452803,"(EA, PCV)",0.15,"[0.12-0.19] unit increase","Illumina, Affymetrix & Perlegen [2,711,806] imputed","N"]
["V5 (down-regulated)","03/19/2013",23222517,"van der Harst P","12/05/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23222517","Seventy-five genetic loci influencing the human red blood cell.","Red blood cell traits","62,553 European ancestry individuals, 9,308 South Asian ancestry individuals","63,506 European ancestry individuals","6p22.2",6,25842951,"SLC17A3, HFE",null,6568,10786,null,10.66,2.38,"rs1408272-G","rs1408272",0,1408272,null,1,0.07,5e-67,66.3010299956639,"(EA, MCH)",0.03,"[0.015-0.051] unit increase","Illumina, Affymetrix & Perlegen [2,711,806] imputed","N"]
["V5 (down-regulated)","03/19/2013",23222517,"van der Harst P","12/05/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23222517","Seventy-five genetic loci influencing the human red blood cell.","Red blood cell traits","62,553 European ancestry individuals, 9,308 South Asian ancestry individuals","63,506 European ancestry individuals","10q22.1",10,71099888,"HK1","- ",null,null,3098,null,null,"rs10159477-A","rs10159477",0,10159477,"intron",0,0.16,4e-20,19.397940008672,"(EA, Hgb)",0.09,"[0.067-0.107] unit increase","Illumina, Affymetrix & Perlegen [2,711,806] imputed","N"]
["V5 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","11q24.3",11,128436953,"ETS1","- ",null,null,2113,null,null,"rs7117932-A","rs7117932",0,7117932,"intron",0,0.287,8e-06,5.09691001300805,"(MCP1 )",0.03,"[NR]  pg/mL increase","Illumina [899,892]","N"]
["V5 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","11q24.2",11,125277494,"PKNOX2","- ",null,null,63876,null,null,"rs7112365-A","rs7112365",0,7112365,"intron",0,0.07,2e-06,5.69897000433601,"(IGFBP-3 )",0.03,"[NR]  ng/mL increase","Illumina [899,892]","N"]
["V5 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","10q24.2",10,101492403,"COX15, CUTC","- ",null,null,"1355;51076",null,null,"rs2281636-A","rs2281636",0,2281636,"UTR-5;intron",0,0.336,6e-06,5.22184874961635,"(LDL )",0.03,"[NR]  mg/dL increase","Illumina [899,892]","N"]
["V5 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","6q25.1",6,152080832,"ESR1","- ",null,null,2099,null,null,"rs60945108-A","rs60945108",0,60945108,"intron",0,0.009,3e-06,5.52287874528033,"(Light activity )",0.03,"[NR]  min/d increase","Illumina [899,892]","N"]
["V5 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","7q36.3",7,158223106,"PTPRN2","- ",null,null,5799,null,null,"rs7786808-G","rs7786808",0,7786808,"intron",0,0.445,8e-06,5.09691001300805,"(Diet protein )",0.03,"[NR]  g/d increase","Illumina [899,892]","N"]
["V5 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","10q24.2",10,100583915,"HPSE2","- ",null,null,60495,null,null,"rs2801405-G","rs2801405",0,2801405,"intron",0,0.33,9e-06,5.04575749056067,"(Urinary free norepinephrine )",0.03,"[NR]  nmol/d increase","Illumina [899,892]","N"]
["V5 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","3p22.1",3,43467895,"ANO10, CCDC13, CCBP2, HIGD1A, FAM198A, SNRK","- ",null,null,55129,null,null,"rs7650267-G","rs7650267",0,7650267,"intron",0,0.093,2e-07,6.69897000433601,"(Eotaxin )",0.04,"[NR]  pg/mL increase","Illumina [899,892]","N"]
["V5 (down-regulated)","04/09/2013",23251661,"Comuzzie AG","12/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/23251661","Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.","Obesity-related traits","815 related Hispanic ancestry children from 263 families","NR","1p36.12",1,20455220,"PLA2G2D",null,26279,64600,null,9.21,10.6,"rs12722987-A","rs12722987",0,12722987,null,1,0.178,7e-06,5.15490195998574,"(BMI z-score change )",0.03,"[NR]  SD/y increase","Illumina [899,892]","N"]
["V5 (down-regulated)","03/19/2013",23209189,"Tabassum R","12/03/2012","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/23209189 ","Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21.","Type 2 diabetes","1,101 Indo-European ancestry cases, 1,027 Indo-European ancestry controls","3,607 Indo-European ancestry cases, 2,924 Indo-European ancestry controls, 1,184 Dravidian ancestry cases, 1,061 Dravidian ancestry controls, 11,285 European ancestry cases, 11,285 European ancestry controls","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-T","rs7903146",0,7903146,"intron",0,0.3,1e-35,35,"(Indo-European South Asians)",1.51,"[1.42-1.62] ","Illumina [536,420]","N"]
["V5 (down-regulated)","02/20/2013",23212062,"Fanous AH","12/01/2012","Am J Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/23212062","Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms.","Schizophrenia","2,454 European ancestry cases","NR","10q11.21",10,44827197,"CXCL12",null,100506835,6387,null,436.32,38.41,"rs10900020-?","rs10900020",0,10900020,null,1,"NR",3e-06,5.52287874528033,"(Positive symptoms)",0.15,"[NR] unit decrease","Affymetrix [696,491]","N"]
["V5 (down-regulated)","01/30/2013",23166209,"Smith JG","11/19/2012","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/23166209","Impact of ancestry and common genetic variants on QT interval in African Americans.","QT interval","13,105 African American individuals","NR","7q36.1",7,150669976,"KCNH2","- ",null,null,3757,null,null,"rs3778872-C","rs3778872",0,3778872,"intron",0,0.64,3e-06,5.52287874528033,null,1.77,"[1.04-2.50] unit decrease","Affymetrix & Illumina [2.8 million] (imputed)","N"]
["V5 (down-regulated)","01/30/2013",23144326,"Kim DK","11/09/2012","Am J Respir Crit Care Med","http://www.ncbi.nlm.nih.gov/pubmed/23144326","Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.","Chronic obstructive pulmonary disease-related biomarkers"," (up-regulated) to 1,951 European ancestry smokers","NR","10q22.3",10,81933748,"ANXA11","- ",null,null,311,null,null,"rs6585424-G","rs6585424",0,6585424,"intron",0,0.13,1e-10,10,"(SP-D)","NR","NR","Illumina (588,352)","N"]
["V5 (down-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","14q24.3",14,75701221,"FOS,MLH3",null,10972,2353,null,57.87,44.26,"rs4899554-C","rs4899554",0,4899554,null,1,0.819,3e-08,7.52287874528033,null,1.08,"[1.042-1.125] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V5 (down-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","6q27",6,167373547,"CCR6,RPS6KA2,RNASET2",null,8635,100500857,null,3.47,37.75,"rs1819333-T","rs1819333",0,1819333,null,1,0.523,7e-21,20.1549019599857,null,1.08,"[1.051-1.113] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V5 (down-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","9q32",9,117553249,"TNFSF8,TNFSF15,TNC","- ",null,null,9966,null,null,"rs4246905-C","rs4246905",0,4246905,"intron",0,0.709,3e-32,31.5228787452803,null,1.14,"[1.106-1.178] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V5 (down-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","1q32.1",1,206939904,"IL10,IL20,IL19,IL24,PIGR,MAPKAPK2,FAIM3,RASSF5",null,9261,3586,null,32.27,1.04,"rs3024505-A","rs3024505",0,3024505,null,1,0.16,7e-42,41.1549019599857,null,1.21,"[1.163-1.254] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V5 (down-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","2p23.2",2,28614794,"FOSL2,BRE","- ",null,null,"2355;403150",null,null,"rs925255-C","rs925255",0,925255,"nearGene-5;intron",0,0.557,3e-15,14.5228787452803,null,1.09,"[1.061-1.124] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V5 (down-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Inflammatory bowel disease","12,924 European ancestry cases, 21,442 European ancestry controls","25,683 European ancestry cases, 17,015 European ancestry controls","14q24.1",14,69273905,"ZFP36L1",null,677,90352,null,10.95,54.54,"rs194749-C","rs194749",0,194749,null,1,0.226,3e-10,9.52287874528033,null,1.08,"[1.039-1.111] ","Affymetrix & Illumina [1.23 million](imputed)","N"]
["V5 (down-regulated)","02/12/2013",23128233,"Jostins L","11/01/2012","Nature","http://www.ncbi.nlm.nih.gov/pubmed/23128233","Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","Ulcerative colitis"," (up-regulated) to 12,924 European ancestry cases,  (up-regulated) to 21,442 European ancestry controls"," (up-regulated) to 25,683 European ancestry cases,  (up-regulated) to 17,015 European ancestry controls","3p21.1",3,53062661,"PRKCD,ITIH4","- ",null,null,"51460;401068",null,null,"rs9847710-C","rs9847710",0,9847710,"intron;intron",0,0.416,1e-08,8,null,1.06,"[1.027-1.102] ","Affymetrix & Illumina [1.23 million] (imputed)","N"]
["V5 (down-regulated)","01/16/2013",23064961,"Shaffer JR","10/11/2012","J Dent Res","http://www.ncbi.nlm.nih.gov/pubmed/23064961","GWAS of dental caries patterns in the permanent dentition.","Dental caries","920 European ancestry individuals","NR","8p21.3",8,20336573,"LZTS1",null,11178,26844,null,223.77,135.79,"rs10111661-?","rs10111661",0,10111661,null,1,"NR",2e-06,5.69897000433601,"(DMFS5max,DMFS5)","NR","NR","Illumina [518,997]","N"]
["V5 (down-regulated)","01/16/2013",23049088,"Meng W","10/09/2012","Invest Ophthalmol Vis Sci","http://www.ncbi.nlm.nih.gov/pubmed/23049088","A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.","Myopia (pathological)","187 European ancestry cases, 1064 European ancestry controls",null,"6p24.3",6,7743663,"BMP6","- ",null,null,654,null,null,"rs9505270-?","rs9505270",0,9505270,"intron",0,0.261,4e-07,6.39794000867203,null,"NR","NR","Affymetrix & Illumina [152,234]","N"]
["V5 (down-regulated)","01/16/2013",23049088,"Meng W","10/09/2012","Invest Ophthalmol Vis Sci","http://www.ncbi.nlm.nih.gov/pubmed/23049088","A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.","Myopia (pathological)","187 European ancestry cases, 1064 European ancestry controls",null,"7q36.3",7,157387441,"PTPRN2","- ",null,null,5799,null,null,"rs10274279-?","rs10274279",0,10274279,"intron",0,0.123,4e-11,10.397940008672,null,"NR","NR","Affymetrix & Illumina [152,234]","N"]
["V5 (down-regulated)","12/05/2012",23001564,"Mangino M","09/25/2012","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/23001564","Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans.","Telomere length","9,190 European ancestry individuals","2,226 individuals","10q24.33",10,105675946,"OBFC1","- ",null,null,79991,null,null,"rs9419958-T","rs9419958",0,9419958,"intron",0,0.1353,9e-11,10.0457574905606,null,0.08,"[0.057-0.108] unit increase","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V5 (down-regulated)","11/20/2012",22936702,"Hofmann S","08/30/2012","Eur Respir J","http://www.ncbi.nlm.nih.gov/pubmed/22936702","Genome-wide association analysis reveals 12q13.3-q14.1 as new risk locus for sarcoidosis.","Sarcoidosis","637 European ancestry cases, 1,233 European ancestry controls","3,121 European ancestry cases, 4,284 European ancestry controls","10q22.3",10,81911725,"ANXA11",null,219348,311,null,6.94,3.16,"rs1953600-?","rs1953600",0,1953600,null,1,"NR",1e-06,5.99999999999999,"(Chronic)","NR","NR","Affymetrix [677,619]","N"]
["V5 (down-regulated)","11/05/2012",22952603,"Hart AB","08/28/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/22952603","Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).","Response to amphetamines","1 American Indian ancestry individual, 18 African American/Afro-Caribbean ancestry individuals, 10 East Asian and South Asian ancestry individuals, 325 European ancestry individuals, 17 Latin American ancestry individuals, 6 other ancestry individuals, 4 individuals","NR","7q36.3",7,158136986,"PTPRN2","- ",null,null,5799,null,null,"rs4909189-?","rs4909189",0,4909189,"intron",0,"NR",3e-06,5.52287874528033,"(SF9)","NR","NR","Affymetrix [5,476,100] (imputed)","N"]
["V5 (down-regulated)","11/05/2012",22952603,"Hart AB","08/28/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/22952603","Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).","Response to amphetamines","1 American Indian ancestry individual, 18 African American/Afro-Caribbean ancestry individuals, 10 East Asian and South Asian ancestry individuals, 325 European ancestry individuals, 17 Latin American ancestry individuals, 6 other ancestry individuals, 4 individuals","NR","16q23.1",16,79073421,"WWOX","- ",null,null,51741,null,null,"rs17713676-?","rs17713676",0,17713676,"intron",0,"NR",8e-06,5.09691001300805,"(SF3)","NR","NR","Affymetrix [5,476,100] (imputed)","N"]
["V5 (down-regulated)","11/21/2012",22916037,"Inouye M","08/16/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22916037","Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.","Metabolite levels","6,608 European ancestry individuals","NR","4q13.3",4,75223711,"EREG",null,255324,2069,null,41.19,7.15,"rs2168889-?","rs2168889",0,2168889,null,1,0.05,6e-14,13.2218487496163,null,"NR","NR","Illumina [~2 million] (imputed)","N"]
["V5 (down-regulated)","10/23/2012",22889924,"Scharf JM","08/14/2012","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22889924","Genome-wide association study of Tourette's syndrome.","Tourette syndrome","778 European ancestry cases, 4,414 European ancestry controls, 242 Ashkenazi Jewish cases, 354 Ashkenazi Jewish controls, 265 French Canadian cases, 196 French Canadian controls","211 Latin American ancestry cases, 285 Latin American ancestry controls","Xp22.11",23,22134658,"PHEX","- ",null,null,5251,null,null,"rs5951698-G","rs5951698",0,5951698,"intron",0,0.0032,6e-06,5.22184874961635,null,5.65,"[NR] ","Illumina [484,295]","N"]
["V5 (down-regulated)","09/29/2012",22883433,"Irish Schizophrenia Genomics Consortium & the Wellcome Trust Case Control Consortium 2","08/07/2012","Biol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22883433","Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia.","Schizophrenia","1,606 European ancestry cases, 1,794 European ancestry controls","13,195 European ancestry cases, 31,021 European ancestry controls","22q13.1",22,39955873,"CACNA1I",null,91582,8911,null,27.01,10.89,"rs9611198-C","rs9611198",0,9611198,null,1,0.458,8e-06,5.09691001300805,null,1.22,"[1.11-1.34] ","Affymetrix [6,212,339]","N"]
["V5 (down-regulated)","09/26/2012",22837378,"Wilk JB","07/26/2012","Am J Respir Crit Care Med","http://www.ncbi.nlm.nih.gov/pubmed/22837378","Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.","Airflow obstruction "," (up-regulated) to 3,368 European ancestry cases,  (up-regulated) to 29,507 European ancestry controls","331 European ancestry cases, 2,550 European ancestry controls","3p24.2",3,25538317,"RARB","- ",null,null,5915,null,null,"rs1997352-?","rs1997352",0,1997352,"intron",0,0.74,9e-07,6.04575749056067,"(All)",1.19,"[NR] ","Affymetrix & Illumina [ (up-regulated) to ~2,500,000] (imputed)","N"]
["V5 (down-regulated)","09/26/2012",22837378,"Wilk JB","07/26/2012","Am J Respir Crit Care Med","http://www.ncbi.nlm.nih.gov/pubmed/22837378","Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.","Airflow obstruction "," (up-regulated) to 3,368 European ancestry cases,  (up-regulated) to 29,507 European ancestry controls","331 European ancestry cases, 2,550 European ancestry controls","1p32.2",1,56359813,"PPAP2B",null,645538,127406,null,525.37,313.33,"rs6684428-A","rs6684428",0,6684428,null,1,0.16,5e-07,6.30102999566398,"(Smoker)",1.23,"[NR] ","Affymetrix & Illumina [ (up-regulated) to ~2,500,000] (imputed)","N"]
["V5 (down-regulated)","09/25/2012",22829776,"Coviello AD","07/19/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22829776","A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.","Sex hormone-binding globulin levels","21,791 European ancestry individuals","8,175 European ancestry individuals","15q26.2",15,96708291,"NR2F2",null,55784,7026,null,1681.11,160.87,"rs8023580-T","rs8023580",0,8023580,null,1,0.72,8e-12,11.096910013008,"(Men + Women)",0.03,"[0.021-0.039] umol/L decrease","Affmyetrix & Illumina [2,543,887] (imputed)","N"]
["V5 (down-regulated)","09/25/2012",22829776,"Coviello AD","07/19/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22829776","A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.","Sex hormone-binding globulin levels","21,791 European ancestry individuals","8,175 European ancestry individuals","15q26.2",15,96708291,"NR2F2",null,55784,7026,null,1681.11,160.87,"rs8023580-T","rs8023580",0,8023580,null,1,0.72,0,null,"(Men)",0.03,"[0.014-0.036] umol/L decrease","Affmyetrix & Illumina [2,543,887] (imputed)","N"]
["V5 (down-regulated)","09/25/2012",22829776,"Coviello AD","07/19/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22829776","A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.","Sex hormone-binding globulin levels","21,791 European ancestry individuals","8,175 European ancestry individuals","15q26.2",15,96708291,"NR2F2",null,55784,7026,null,1681.11,160.87,"rs8023580-T","rs8023580",0,8023580,null,1,0.72,8e-08,7.09691001300805,"(Women)",0.04,"[0.024-0.052] umol/L decrease","Affmyetrix & Illumina [2,543,887] (imputed)","N"]
["V5 (down-regulated)","11/22/2012",22699663,"Divaris K","07/01/2012","J Dent Res","http://www.ncbi.nlm.nih.gov/pubmed/22699663","Genome-wide association study of periodontal pathogen colonization.","Periodontal microbiota","1,020 European ancestry individuals","NR","14q24.3",14,75814028,"FOS, JDP2",null,2353,122953,null,65.09,80.48,"rs11621969-T","rs11621969",0,11621969,null,1,0.789,9e-07,6.04575749056067,"(A. actino)",2.46,"[1.68-3.62] ","Affymetrix [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","11/22/2012",22699663,"Divaris K","07/01/2012","J Dent Res","http://www.ncbi.nlm.nih.gov/pubmed/22699663","Genome-wide association study of periodontal pathogen colonization.","Periodontal microbiota","1,020 European ancestry individuals","NR","1p36.23",1,7521585,"CAMTA1, VAMP3","- ",null,null,23261,null,null,"rs1616122-T","rs1616122",0,1616122,"intron",0,0.506,5e-06,5.30102999566398,"(Orange)",1.85,"[1.41-2.42] ","Affymetrix [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","09/20/2012",22751097,"Lu X","07/01/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22751097","Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.","Coronary heart disease","1,515 Han Chinese cases, 5,019 Han Chinese controls","15,460 Han Chinese cases, 11,472 Han Chinese controls","12q21.33",12,90081188,"ATP2B1",null,490,347894,null,31.34,65.5,"rs7136259-T","rs7136259",0,7136259,null,1,0.39,6e-10,9.22184874961635,null,1.11,"[1.08-1.15] ","Affymetrix [~2.2 million] (imputed)","N"]
["V5 (down-regulated)","08/20/2012",22747683,"Eriksson N","06/30/2012","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/22747683","Genetic variants associated with breast size also influence breast cancer risk.","Breast size","16,175 European ancestry women","NR","6q25.1",6,151957714,"ESR1, C6orf97",null,80129,2099,null,15.39,53.92,"rs12173570-T","rs12173570",0,12173570,null,1,0.101,6e-11,10.2218487496163,null,0.17,"[0.12-0.22] c (up-regulated) size increase","Illumina [7,422,970] (imputed)","N"]
["V5 (down-regulated)","08/20/2012",22747683,"Eriksson N","06/30/2012","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/22747683","Genetic variants associated with breast size also influence breast cancer risk.","Breast size","16,175 European ancestry women","NR","4q13.3",4,75502487,"AREG, EREG, EPGN, AREGB",null,374,685,null,181.76,168.96,"rs62314947-T","rs62314947",0,62314947,null,1,0.281,5e-08,7.30102999566398,null,0.1,"[0.064-0.138] c (up-regulated) size decrease","Illumina [7,422,970] (imputed)","N"]
["V5 (down-regulated)","08/10/2012",22719876,"Kawaguchi T","06/14/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/22719876","Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese.","Nonalcoholic fatty liver disease","529 Japanese ancestry cases, 932 Japanese ancestry controls","NR","22q13.31",22,44324727,"PNPLA3","- ",null,null,80339,null,null,"rs738409-G","rs738409",0,738409,"missense",0,0.484,1e-10,10,null,1.66,"[1.43-1.94] ","Illumina [484,751]","N"]
["V5 (down-regulated)","08/15/2012",22703881,"Tang W","06/14/2012","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/22703881","Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.","Activated partial thromboplastin time","9,240 European ancestry individuals","2611 European ancestry individuals","5q35.3",5,176841339,"UIMC1, FGFR4, NSD1, PRELID1, MXD3, LMAN2, RGS14, SLC34A1, PRR7, DBN1, F12, GRK6",null,2161,2870,null,4.76,12.35,"rs2545801-C","rs2545801",0,2545801,null,1,"NR",6e-88,87.2218487496163,null,1.68,"[1.48-1.88] unit decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","08/14/2012",22688191,"Bergen SE","06/12/2012","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/22688191","Genome-wide association study in a Swedish population yields s (up-regulated)port for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.","Schizophrenia","2,111 European ancestry schizophrenia cases, 2,535 European ancestry controls","11,271 schizophrenia cases, 14,601 controls","11q24.2",11,125323965,"PKNOX2, FEZ1, El24","- ",null,null,9638,null,null,"rs11220082-?","rs11220082",0,11220082,"intron",0,"NR",7e-07,6.15490195998574,null,1.1,"[NR] ","Affymetrix [745,006]","N"]
["V5 (down-regulated)","08/07/2012",22693455,"Perry JR","05/31/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22693455","Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.","Type 2 diabetes","2,112 lean type 2 diabetes cases, 4,123 obese type 2 diabetes cases, 54,412 controls","2,881 lean type 2 diabetes cases, 8,702 obese type 2 diabetes cases, 18,957 controls","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-T","rs7903146",0,7903146,"intron",0,0.29,2e-40,39.698970004336,"(Lean)",1.58,"[1.47-1.68] ","NR","N"]
["V5 (down-regulated)","08/07/2012",22693455,"Perry JR","05/31/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22693455","Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.","Type 2 diabetes","2,112 lean type 2 diabetes cases, 4,123 obese type 2 diabetes cases, 54,412 controls","2,881 lean type 2 diabetes cases, 8,702 obese type 2 diabetes cases, 18,957 controls","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-T","rs7903146",0,7903146,"intron",0,0.29,4e-21,20.397940008672,"(Obese)",1.26,"[1.20 - 1.32] ","NR","N"]
["V5 (down-regulated)","07/19/2012",22648509,"Wang KS","05/31/2012","J Mol Neurosci","http://www.ncbi.nlm.nih.gov/pubmed/22648509","PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies.","Formal thought disorder in schizophrenia","835 European ancestry cases, 2,694 European ancestry controls","NR","11q24.2",11,125304009,"PKNOX2",null,63876,9638,null,0.72,11.63,"rs1783925-?","rs1783925",0,1783925,null,1,0.7,4e-07,6.39794000867203,null,1.39,"[NR] ","Affymetrix [729,454]","N"]
["V5 (down-regulated)","08/07/2012",22610502,"Kennedy RB","05/19/2012","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/22610502","Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.","Immune reponse to smallpox (secreted IFN-alpha)"," (up-regulated) to 512 European ancestry individuals,  (up-regulated) to 199 African American individuals","NR","Xp22.11",23,22148051,"PHEX","- ",null,null,5251,null,null,"rs1540283-G","rs1540283",0,1540283,"intron",0,"NR",9e-09,8.04575749056067,"(AA)","NR","NR","Illumina [NR]","N"]
["V5 (down-regulated)","08/15/2012",22581228,"Manning AK","05/13/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22581228","A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.","Fasting glucose-related traits (interaction with BMI)"," (up-regulated) to 58,074 European ancestry individuals"," (up-regulated) tp 38,422 European ancestry individuals","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-?","rs7903146",0,7903146,"intron",0,"NR",2e-14,13.698970004336,null,"NR","NR","Affymetrix & Illumina [~2.4 million] (imputed)","N"]
["V5 (down-regulated)","08/15/2012",22581228,"Manning AK","05/13/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22581228","A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.","Fasting insulin-related traits (interaction with BMI)"," (up-regulated) to 51,750 European ancestry individuals"," (up-regulated) to 33,823 European ancestry individuals","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-?","rs7903146",0,7903146,"intron",0,"NR",3e-06,5.52287874528033,null,"NR","NR","Affymetrix & Illumina [~2.4 million] (imputed)","N"]
["V5 (down-regulated)","08/17/2012",22589738,"Fox CS","05/10/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22589738","Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.","Visceral adipose tissue/subcutaneous adipose tissue ratio","5,560 European ancestry women and 4,997 European ancestry men","NR","3p22.1",3,42093422,"TRAK1","- ",null,null,100287063,null,null,"rs1498095-T","rs1498095",0,1498095,"intron",0,0.91,8e-06,5.09691001300805,"(men)","NR","NR","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V5 (down-regulated)","08/17/2012",22589738,"Fox CS","05/10/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22589738","Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.","Visceral fat","5,560 European ancestry women and 4,997 European ancestry men","NR","11p11.2",11,45813581,"CRY2, SLC35C1",null,8534,55343,null,126.38,12.04,"rs12285276-G","rs12285276",0,12285276,null,1,0.76,9e-06,5.04575749056067,"(men)","NR","NR","Affymetrix & Illumina [2.5 million] (imputed)","N"]
["V5 (down-regulated)","07/11/2012",22561518,"Jin Y","05/06/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22561518","Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.","Vitiligo","418 European ancestry cases, 2,810 European ancestry controls        ","1,377 European ancestry cases, 1,284 European ancestry controls","22q13.2",22,41757647,"TOB2",null,23264,7008,null,1.5,5.69,"rs4822024-G","rs4822024",0,4822024,null,1,0.79,7e-10,9.15490195998574,null,1.28,"[NR] ","Illumina [495,821]","N"]
["V5 (down-regulated)","07/10/2012",22569225,"Krintel SB","05/06/2012","Pharmacogenet Genomics","http://www.ncbi.nlm.nih.gov/pubmed/22569225","Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNF&#x003b1; inhibitors in patients with rheumatoid arthritis.","Response to TNF-alpha inhibitors in rheumatoid arthritis","196 European ancestry cases","NR","15q26.2",15,96141867,"NR2F2",null,55784,7026,null,1114.69,727.29,"rs10520789-?","rs10520789",0,10520789,null,1,"NR",6e-07,6.22184874961635,"(Change in DAS28)","NR","NR","Illumina [486,450]","N"]
["V5 (down-regulated)","07/04/2012",22542470,"Ovsyannikova IG","04/25/2012","Vaccine","http://www.ncbi.nlm.nih.gov/pubmed/22542470","Genome-wide association study of antibody response to smallpox vaccine.","Immune response to smallpox vaccine (IL-6)","217 African American ancestry individuals, 580 European ancestry individuals, 217 Hispanic ancestry individuals","NR","21q22.12",21,36238507,"RUNX1","- ",null,null,861,null,null,"rs2834655-?","rs2834655",0,2834655,"intron",0,"NR",5e-07,6.30102999566398,"(AA)","NR","NR","Illumina [NR]","N"]
["V5 (down-regulated)","07/04/2012",22542470,"Ovsyannikova IG","04/25/2012","Vaccine","http://www.ncbi.nlm.nih.gov/pubmed/22542470","Genome-wide association study of antibody response to smallpox vaccine.","Immune response to smallpox vaccine (IL-6)","217 African American ancestry individuals, 580 European ancestry individuals, 217 Hispanic ancestry individuals","NR","10q23.33",10,96766934,"CYP2C9",null,1559,100874505,null,17.79,0.22,"rs2860975-?","rs2860975",0,2860975,null,1,"NR",2e-07,6.69897000433601,"(Hispanic)","NR","NR","Illumina [NR]","N"]
["V5 (down-regulated)","05/15/2012",22488850,"Zuo L","04/04/2012","Am J Med Genet B Neuropsychiatr Genet","http://www.ncbi.nlm.nih.gov/pubmed/22488850","Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.","Alcohol and nictotine co-dependence","818 European ancestry cases, 1,396 European ancestry controls, 449 African American cases, 480 African American controls","NR","3p25.1",3,15295364,"SH3BP5, NR2C2, ZFYVE20","- ",null,null,"9467;100505696",null,null,"rs1318937-?","rs1318937",0,1318937,"nearGene-3;nearGene-5",0,"NR",4e-07,6.39794000867203,null,"NR","NR","Illumina [805,814]","N"]
["V5 (down-regulated)","05/15/2012",22488850,"Zuo L","04/04/2012","Am J Med Genet B Neuropsychiatr Genet","http://www.ncbi.nlm.nih.gov/pubmed/22488850","Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.","Alcohol and nictotine co-dependence","818 European ancestry cases, 1,396 European ancestry controls, 449 African American cases, 480 African American controls","NR","11q24.2",11,125170639,"PKNOX2","- ",null,null,63876,null,null,"rs1426153-?","rs1426153",0,1426153,"intron",0,"NR",2e-06,5.69897000433601,null,"NR","NR","Illumina [805,814]","N"]
["V5 (down-regulated)","04/27/2012",22446963,"Okada Y","03/25/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22446963","Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.","Rheumatoid arthritis","4,074 Japanese ancestry cases, 16,891 Japanese ancestry controls","5,277 Japanese ancestry cases, 21,684 Japanese ancestry controls","11q24.3",11,128492739,"ETS1, FLI1",null,2113,100507392,null,35.29,68.83,"rs4937362-T","rs4937362",0,4937362,null,1,0.68,8e-07,6.09691001300805,null,1.09,"[1.06-1.13] ","Affymetrix & Illumina [1,948,139] ","N"]
["V5 (down-regulated)","04/27/2012",22424883,"Imboden M","03/15/2012","J Allergy Clin Immunol","http://www.ncbi.nlm.nih.gov/pubmed/22424883","Genome-wide association study of lung function decline in adults with and without asthma.","Pulmonary function decline","1,441 European ancestry asthma cases, 2,677 European ancestry controls","1,160 European ancestry asthma cases, 10,858 European ancestry controls","20p11.23",20,19363979,"SLC24A3","- ",null,null,57419,null,null,"rs2424234-?","rs2424234",0,2424234,"intron",0,"NR",3e-06,5.52287874528033,"(FEV1/FVC decline in non-asthmatics)",0.21,"[0.12-0.3] unit decrease","Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","04/18/2012",22419666,"Shi M","03/14/2012","Am J Med Genet A","http://www.ncbi.nlm.nih.gov/pubmed/22419666","Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts.","Orofacial clefts","1,094 European ancestry triads, 1,277 Asian ancestry triads and 87 other ancestry triads","NR","6p24.3",6,7736743,"BMP6","- ",null,null,654,null,null,"rs2068361-?","rs2068361",0,2068361,"intron",0,0.23,5e-06,5.30102999566398,"(CL)",1.64,"[1.32-2.04 ","Illumina [NR]","N"]
["V5 (down-regulated)","04/03/2012",22412388,"Kenny EE","03/08/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22412388","A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.","Crohn's disease","737 Ashkenazi Jewish cases, 2,257  Ashkenazi Jewish controls","971 Ashkenazi Jewish cases, 2,124 Ashkenazi Jewish controls","10q24.2",10,101292390,"NKX2-3, SLC25A28, GOT1, ENTPD7, CNNM1, COX15, CUTC","- ",null,null,159296,null,null,"rs11190141-C","rs11190141",0,11190141,"nearGene-5",0,0.739,5e-07,6.30102999566398,null,1.34,"[1.25-1.43] ","Affyemtrix & Illumina [1,060,934] (imputed)","N"]
["V5 (down-regulated)","03/17/2012",22383897,"Long J","02/23/2012","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/22383897","Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer.","Breast cancer","2,918 Chinese ancestry cases, 2,324 Chinese ancestry controls"," (up-regulated) to 6,838 Chinese ancestry cases,  (up-regulated) to 6,888 Chinese ancestry controls,  (up-regulated) to 1,297 Han Chinese cases,  (up-regulated) to 1,585 Han Chinese controls,  (up-regulated) to 1,066 Taiwan Chinese cases,  (up-regulated) to 1,065 Taiwan Chinese controls,  (up-regulated) to 5,038 Korean ancestry cases,  (up-regulated) to 6,869 Korean ancestry controls,  (up-regulated) to 1,934 Japanese ancestry cases,  (up-regulated) to 1,875 Japanese ancestry controls","6q25.1",6,152295613,"ESR1","- ",null,null,2099,null,null,"rs9383951-G","rs9383951",0,9383951,"intron",0,0.9,2e-06,5.69897000433601,null,1.14,"[1.08-1.19] ","Affymetrix [690,947]","N"]
["V5 (down-regulated)","03/09/2012",22306650,"Thye T","02/05/2012","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22306650","Common variants at 11p13 are associated with susceptibility to tuberculosis.","Tuberculosis","1,329 African ancestry cases, 1,847 African ancestry controls","2,024 African ancestry cases, 5,154 African ancestry controls, 1,025 Indonesian ancestry cases, 983 Indonesian ancestry controls, 4,441 European ancestry cases, 5,874 European ancestry controls","11p13",11,32364187,"WT1",null,5954,7490,null,236.92,45.13,"rs2057178-?","rs2057178",0,2057178,null,1,"NR",3e-11,10.5228787452803,null,1.1,"[1.01-1.22] Russian samples","Affymetrix [793,964]","N"]
["V5 (down-regulated)","02/07/2012",22238593,"Palmer ND","01/04/2012","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/22238593","A genome-wide association search for type 2 diabetes genes in African Americans.","Type 2 diabetes","965 African American ancestry cases, 1,029 African American ancestry controls","2,167 African American ancestry cases, 2,288 African American ancestry controls","2q23.3",2,151637936,"RBM43, RND3",null,390,344332,null,293.73,404.74,"rs7560163-C","rs7560163",0,7560163,null,1,0.86,7e-09,8.15490195998574,null,1.33,"[1.19-1.49] ","Affymetrix [832,357]","N"]
["V5 (down-regulated)","03/31/2012",22219177,"Tao S","01/04/2012","Carcinogenesis","http://www.ncbi.nlm.nih.gov/pubmed/22219177","A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.","Prostate cancer (gene x gene interaction)","4,723 cases, 4,792 controls","NR","15q26.2",15,97002653,"NR2F2",null,100128250,388181,null,10.89,297.56,"rs11637980-?","rs11637980",0,11637980,null,1,"NR",2e-06,5.69897000433601,"(rs1447295)",1.47,"[1.27-1.72] ","Affymetrix & Illumina [1,117,531] (imputed)","N"]
["V5 (down-regulated)","01/18/2012",22158537,"Cho YS","12/11/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22158537","Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.","Type 2 diabetes","4,026 Chinese ancestry cases, 1,042 Korean ancestry cases, 794 Malaysian ancestry cases, 931 Japanese ancestry cases, 159 Filipino ancestry cases, 4,654 Chinese ancestry controls, 2,943 Korean ancestry controls, 1,240 Malaysian ancestry controls, 1,404 Japanese ancestry controls, 1,624 Filipino ancestry controls.","9,723 Japanese ancestry cases, 1,815 Korean ancestry cases, 6,589 Chinese ancestry cases, 8,974 Japanese ancestry controls, 2,066 Korean ancestry controls, Chinese ancestry controls.","16q23.2",16,79406918,"WWOX",null,645957,4094,null,546.94,220.83,"rs17797882-T","rs17797882",0,17797882,null,1,0.32,9e-07,6.04575749056067,null,1.08,"[1.05�.12] ","Affymetrix & Illumina [2,626,356](imputed)","N"]
["V5 (down-regulated)","11/16/2012",22139419,"Gieger C","11/30/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/22139419","New gene functions in megakaryopoiesis and platelet formation.","Mean platelet volume","18,600 European ancestry individuals"," (up-regulated) to 18,838 European ancestry individuals","3q21.2",3,124340222,"KALRN","- ",null,null,8997,null,null,"rs10512627-C","rs10512627",0,10512627,"intron",0,"NR",5e-10,9.30102999566398,null,0.01,"[0.004-0.008] ln(fl) increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","11/16/2012",22139419,"Gieger C","11/30/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/22139419","New gene functions in megakaryopoiesis and platelet formation.","Platelet counts","48,666 individuals of European ancestry"," (up-regulated) to 18,838 individuals of European ancestry","11q23.3",11,119099906,"CBL","- ",null,null,867,null,null,"rs4938642-C","rs4938642",0,4938642,"intron",0,"NR",8e-11,10.096910013008,null,4.73,"[3.31-6.15] 10^9/l increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","12/17/2011",22101970,"Kho AN","11/19/2011","J Am Med Inform Assoc","http://www.ncbi.nlm.nih.gov/pubmed/22101970","Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study.","Type 2 diabetes","2,413 European ancestry cases, 810 African American cases, 2,392 European ancestry controls, 873 African American controls","NR","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-T","rs7903146",0,7903146,"intron",0,"0.26 (EA+AA)",2e-15,14.698970004336,null,1.46,"[NR] ","Illumina [NR]","N"]
["V5 (down-regulated)","12/16/2011",22075330,"Granada M","11/08/2011","J Allergy Clin Immunol","http://www.ncbi.nlm.nih.gov/pubmed/22075330","A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.","IgE levels ","6,819 European ancestry individuals","7,809 European ancestry indivduals","12q13.3",12,57489709,"STAT6, NAB2","- ",null,null,"4665;6778",null,null,"rs1059513-C","rs1059513",0,1059513,"nearGene-3;ncRNA",0,"NR",2e-12,11.698970004336,null,0.12,"[NR] unit decrease","Affymetrix [2,540,223] (imputed)","N"]
["V5 (down-regulated)","11/25/2011",22021425,"Carty CL","10/21/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/22021425","Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe).","Height","8,149 African American ancestry women"," (up-regulated) to 20,809 African American ancestry and African ancestry individuals","17q24.2",17,64779430,"PRKCA","- ",null,null,5578,null,null,"rs3889237-C","rs3889237",0,3889237,"intron",0,0.14,3e-08,7.52287874528033,null,0.06,"[0.029-0.083] unit decrease","Affymetrix [855,034]","N"]
["V5 (down-regulated)","11/18/2011",22001757,"Chambers JC","10/16/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22001757","Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.","Liver enzyme levels (alanine transaminase)"," (up-regulated) to 52,350 European ancestry individuals,  (up-regulated) to 8,739 Indian Asian individuals","NR","22q13.31",22,44324727,"PNPLA3, SAMM50","- ",null,null,80339,null,null,"rs738409-G","rs738409",0,738409,"missense",0,0.23,1e-45,44.9999999999999,null,6,"[5.0-7.0] % increase","Affymetrix, Illumina, and Perlegen [~2.6 million] (imputed)","N"]
["V5 (down-regulated)","11/18/2011",22001757,"Chambers JC","10/16/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/22001757","Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.","Liver enzyme levels (alkaline phosphatase)"," (up-regulated) to 52,350 European ancestry individuals,  (up-regulated) to 8,739 Indian Asian individuals","NR","11q24.2",11,126283785,"ST3GAL4","- ",null,null,6484,null,null,"rs2236653-T","rs2236653",0,2236653,"intron",0,0.42,2e-09,8.69897000433601,null,1.5,"[0.60-2.50] % increase","Affymetrix, Illumina, and Perlegen [~2.6 million] (imputed)","N"]
["V5 (down-regulated)","11/08/2011",21998595,"N'Diaye A","10/06/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21998595","Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.","Height","20,427 African ancestry individuals"," (up-regulated) to 16,436 African American individuals","2q35",2,218729865,"TNS1","- ",null,null,7145,null,null,"rs3791950-A","rs3791950",0,3791950,"intron",0,0.89,2e-06,5.69897000433601,null,0.06,"[0.036-0.086] unit decrease","Affymetrix & Illumina [3,310,998] (imputed)","N"]
["V5 (down-regulated)","10/22/2011",21956439,"Zuo L","09/28/2011","Neuropsychopharmacology","http://www.ncbi.nlm.nih.gov/pubmed/21956439","Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.","Alcohol dependence","1,409 European ancestry cases, 1,518 European ancestry controls, 681 African American cases, 508 African American controls","NR","11q24.2",11,125178403,"PKNOX2","- ",null,null,63876,null,null,"rs10893366-?","rs10893366",0,10893366,"intron",0,"NR",8e-06,5.09691001300805,"(EA + AA)","NR","NR","Illumina [805,814]","N"]
["V5 (down-regulated)","10/22/2011",21956439,"Zuo L","09/28/2011","Neuropsychopharmacology","http://www.ncbi.nlm.nih.gov/pubmed/21956439","Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.","Alcohol dependence","1,409 European ancestry cases, 1,518 European ancestry controls, 681 African American cases, 508 African American controls","NR","3p25.1",3,15295364,"SH3BP5","- ",null,null,"9467;100505696",null,null,"rs1318937-?","rs1318937",0,1318937,"nearGene-3;nearGene-5",0,"NR",3e-06,5.52287874528033,"(EA + AA)","NR","NR","Illumina [805,814]","N"]
["V5 (down-regulated)","10/18/2011",21946350,"Soler Artigas M","09/25/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21946350","Genome-wide association and large-scale follow  (up-regulated) identifies 16 new loci influencing lung function.","Pulmonary function","48,201 European ancestry individuals","46,411 European ancestry individuals","16q23.1",16,78188738,"WWOX","- ",null,null,51741,null,null,"rs12716852-G","rs12716852",0,12716852,"intron",0,"NR",2e-07,6.69897000433601,"(FEV1)",0.03,"[0.015-0.035] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","10/16/2011",21946350,"Soler Artigas M","09/25/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21946350","Genome-wide association and large-scale follow  (up-regulated) identifies 16 new loci influencing lung function.","Pulmonary function","48,201 European ancestry individuals","46,411 European ancestry individuals","3p24.2",3,25520582,"RARB","- ",null,null,5915,null,null,"rs1529672-C","rs1529672",0,1529672,"intron",0,0.83,4e-14,13.397940008672,"(FEV1/FVC)",0.05,"[0.036-0.060] unit decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","10/18/2011",21946350,"Soler Artigas M","09/25/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21946350","Genome-wide association and large-scale follow  (up-regulated) identifies 16 new loci influencing lung function.","Pulmonary function","48,201 European ancestry individuals","46,411 European ancestry individuals","6p22.1",6,28322296,"ZKSCAN3, ZNF323","- ",null,null,80317,null,null,"rs6903823-G","rs6903823",0,6903823,"intron",0,0.21,2e-10,9.69897000433601,"(FEV1)",0.04,"[0.025-0.049] unit decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","10/20/2011",21943158,"Middelberg RP","09/24/2011","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/21943158","Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.","Cardiovascular disease risk factors","11,683 individuals","NR","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-A","rs1800562",0,1800562,"missense",0,0.08,5e-12,11.3010299956639,"(FERR)",0.18,"[0.13-0.23] mg/l increase","Illumina [NR] (imputed)","N"]
["V5 (down-regulated)","10/19/2011",21926972,"Sklar P","09/18/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21926972","Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.","Bipolar disorder","7,481 European ancestry cases, 9,250 European ancestry controls","4,496 European ancestry cases, 42,422 European ancestry controls","11q13.2",11,66551002,"ZDHHC24, YIF1A, TMEM151A, SYT12, SPTBN2,SLC29A2, SF3B2, RIN1, RCE1, RBM4B, RBM4, RBM14, RAB1B, PELI3, PC, PACS1, NPAS4, MRPL11, LRFN4, KLC2, GAL3ST3, DPP3, CTSF, CNIH2, CD248, CCS, CCDC87, C11orf86, C11orf80, BRMS1, BBS1, B3GNT1, ACTN3","- ",null,null,79703,null,null,"rs10896135-G","rs10896135",0,10896135,"intron",0,"NR",2e-07,6.69897000433601,null,1.12,"[NR] ","Affymetrix & Illumina [2,415,422] (imputed)","N"]
["V5 (down-regulated)","10/19/2011",21926972,"Sklar P","09/18/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21926972","Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.","Bipolar disorder","7,481 European ancestry cases, 9,250 European ancestry controls","4,496 European ancestry cases, 42,422 European ancestry controls","3p21.1",3,52835354,"WDR82, TWF2, TNNC1, TMEM110, TLR9, STAB1,SPCS1, SNORD69, SNORD19, SNORD19B, SFMBT1, SEMA3G, RFT1, PRKCD, PPM1M, PHF7, PBRM1, NT5DC2, NISCH, NEK4, MUSTN1, LOC440957, ITIH1, ITIH3, ITIH4, GNL3, GLYCTK, GLT8D1, DNAH1, BAP1, ALAS1","- ",null,null,3699,null,null,"rs736408-C","rs736408",0,736408,"intron",0,"NR",2e-06,5.69897000433601,null,1.1,"[NR] ","Affymetrix & Illumina [2,415,422] (imputed)","N"]
["V5 (down-regulated)","10/21/2011",21909115,"Ehret GB","09/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21909115","Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.","Diastolic blood pressure","69,395 European ancestry individuals"," (up-regulated) to 133,361 European ancestry individuals","6p22.2",6,26091179,"HFE","- ",null,null,3077,null,null,"rs1799945-G","rs1799945",0,1799945,"missense",0,0.14,2e-15,14.698970004336,null,0.46,"[NR] mmHg increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","10/21/2011",21909115,"Ehret GB","09/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21909115","Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.","Hypertension","69,395 European ancestry individuals"," (up-regulated) to 133,361 European ancestry individuals","6p22.2",6,26091179,"HFE","- ",null,null,3077,null,null,"rs1799945-G","rs1799945",0,1799945,"missense",0,0.14,2e-10,9.69897000433601,null,0.1,"[NR] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","10/21/2011",21909115,"Ehret GB","09/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21909115","Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.","Systolic blood pressure","69,395 European ancestry individuals"," (up-regulated) to 133,361 European ancestry individuals","6p22.2",6,26091179,"HFE","- ",null,null,3077,null,null,"rs1799945-G","rs1799945",0,1799945,"missense",0,0.14,8e-12,11.096910013008,null,0.63,"[NR] mmHg increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","10/11/2011",21909109,"Kim YJ","09/11/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21909109","Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.","Metabolite levels","12,545 Korean ancestry individuals"," (up-regulated) to 30,395 East Asian ancestry individuals","22q13.31",22,44325996,"PNPLA3","- ",null,null,80339,null,null,"rs12483959-A","rs12483959",0,12483959,"intron",0,0.42,2e-39,38.698970004336,"(ALT)",0,"[0.00080-0.00120] IU/L increase","Affymetrix [~2.2 million] (imputed)","N"]
["V5 (down-regulated)","10/11/2011",21909109,"Kim YJ","09/11/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21909109","Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.","Metabolite levels","12,545 Korean ancestry individuals"," (up-regulated) to 30,395 East Asian ancestry individuals","22q13.31",22,44325996,"PNPLA3","- ",null,null,80339,null,null,"rs12483959-A","rs12483959",0,12483959,"intron",0,0.42,2e-18,17.698970004336,"(ALT)",0,"[0.0031-0.0047] IU/L decrease","Affymetrix [~2.2 million] (imputed)","N"]
["V5 (down-regulated)","10/11/2011",21909110,"Wain LV","09/11/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21909110","Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.","Blood pressure","74,064 European ancestry individuals","48,607 European ancestry individuals","6p22.2",6,26107463,"HFE","- ",null,null,3010,null,null,"rs198846-G","rs198846",0,198846,"nearGene-3",0,0.86,2e-12,11.698970004336,"(Mean Arterial Pressure)",0.48,"[0.35-0.61] mmHg decrease","Affymetrix, Illumina, and Perlegen [NR] (imputed)","N"]
["V5 (down-regulated)","10/11/2011",21909110,"Wain LV","09/11/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21909110","Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.","Blood pressure","74,064 European ancestry individuals","48,607 European ancestry individuals","12q21.33",12,90060586,"ATP2B1",null,490,347894,null,10.74,86.1,"rs17249754-G","rs17249754",0,17249754,null,1,0.89,1e-17,17,"(Mean Arterial Pressure)",0.56,"[0.43-0.69] mmHg increase","Affymetrix, Illumina, and Perlegen [NR] (imputed)","N"]
["V5 (down-regulated)","10/11/2011",21909110,"Wain LV","09/11/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21909110","Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.","Blood pressure","74,064 European ancestry individuals","48,607 European ancestry individuals","12q21.33",12,90060586,"ATP2B1",null,490,347894,null,10.74,86.1,"rs17249754-G","rs17249754",0,17249754,null,1,0.89,6e-10,9.22184874961635,"(Pulse Pressure)",0.39,"[0.27-0.52] mmHg increase","Affymetrix, Illumina, and Perlegen [NR] (imputed)","N"]
["V5 (down-regulated)","10/11/2011",21909110,"Wain LV","09/11/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21909110","Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.","Blood pressure","74,064 European ancestry individuals","48,607 European ancestry individuals","1p36.22",1,11862778,"MTHFR, NPPB","- ",null,null,4524,null,null,"rs17367504-G","rs17367504",0,17367504,"intron",0,0.17,2e-16,15.698970004336,"(Mean Arterial Pressure)",0.53,"[0.40-0.66] mmHg decrease","Affymetrix, Illumina, and Perlegen [NR] (imputed)","N"]
["V5 (down-regulated)","02/24/2012",21886157,"Suhre K","08/31/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21886157","Human metabolic individuality in biomedical and pharmaceutical research.","Metabolic traits","2,820 European ancestry individuals","NR","8q24.3",8,145139522,"OPLAH","- ",null,null,8733,null,null,"rs6558295-G","rs6558295",0,6558295,"intron",0,0.083,2e-59,58.698970004336,"(5-oxoproline)",0.12,"[NR] unit decrease","Affmyetrix & Illumina [534,665] ","N"]
["V5 (down-regulated)","09/27/2011",21873549,"Strawbridge RJ","08/26/2011","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/21873549","Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.","Proinsulin levels","10,701 European ancestry nondiabetic adults","16,378 European ancestry nondiabetic adults","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-T","rs7903146",0,7903146,"intron",0,0.3,2e-20,19.698970004336,null,"NR","NR","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","10/24/2012",21833088,"Sawcer S","08/11/2011","Nature","http://www.ncbi.nlm.nih.gov/pubmed/21833088","Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.","Multiple sclerosis","9,772 European ancestry cases, 16,849 European ancestry controls","4,218 European ancestry cases, 7,296 European ancestry controls","14q24.1",14,69254191,"ZFP36L1","- ",null,null,677,null,null,"rs4902647-G","rs4902647",0,4902647,"nearGene-3",0,"NR",9e-12,11.0457574905606,null,1.11,"[1.1-1.13] ","Illumina [465,434]","N"]
["V5 (down-regulated)","09/06/2011",21846871,"Mehta NN","08/01/2011","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/21846871","A genome-wide association study in europeans and South asians identifies 5 new Loci for coronary artery disease.","Coronary heart disease","8,424 European ancestry cases, 6,996 South Asian cases, 15,062 controls","21,408 cases, 19,185 controls","1p32.2",1,56966350,"PPAP2B","- ",null,null,8613,null,null,"rs17114046-?","rs17114046",0,17114046,"intron",0,"NR",3e-07,6.52287874528033,null,"NR","NR","Illumina [~575,00]","N"]
["V5 (down-regulated)","08/27/2011",21804548,"Hirota T","07/31/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21804548","Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.","Asthma","1,532 Japanese ancestry cases, 3,304 Japanese ancestry controls","5,639 Japanese ancestry cases, 24,608 Japanese ancestry controls","4q31.21",4,144357737,"GAB1","- ",null,null,2549,null,null,"rs3805236-G","rs3805236",0,3805236,"intron",0,0.25,7e-08,7.15490195998574,null,1.12,"[1.08-1.17] ","Illumina [458,847]","N"]
["V5 (down-regulated)","09/01/2011",21829377,"Lemaitre RN","07/28/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21829377","Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.","Phospholipid levels (plasma)","8,866 European ancestry individuals","NR","21q22.12",21,36416332,"RUNX1","- ",null,null,861,null,null,"rs9983044-C","rs9983044",0,9983044,"intron",0,"NR",2e-07,6.69897000433601,"(EPA)",0.07,"[NR] % increase","Affymetrix & Illumina [NR]","N"]
["V5 (down-regulated)","08/18/2011",21785125,"Traglia M","07/25/2011","J Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/21785125","Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations.","Hepcidin levels","1,657 individuals","NR","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-?","rs1800562",0,1800562,"missense",0,"NR",3e-07,6.52287874528033,"(ferritin)",0.39,"[0.24-0.54] ng/ml increase","Illumina [343,866]","N"]
["V5 (down-regulated)","08/18/2011",21785125,"Traglia M","07/25/2011","J Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/21785125","Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations.","Hepcidin levels","1,657 individuals","NR","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-?","rs1800562",0,1800562,"missense",0,"NR",3e-15,14.5228787452803,"(Tf Sat)",0.61,"[0.46-0.76] ng/ml increase","Illumina [343,866]","N"]
["V5 (down-regulated)","08/18/2011",21785125,"Traglia M","07/25/2011","J Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/21785125","Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations.","Hepcidin levels","1,657 individuals","NR","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-?","rs1800562",0,1800562,"missense",0,"NR",4e-09,8.39794000867203,"(Iron)",0.44,"[0.29-0.59] ng/ml increase","Illumina [343,866]","N"]
["V5 (down-regulated)","08/18/2011",21785125,"Traglia M","07/25/2011","J Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/21785125","Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations.","Hepcidin levels","1,657 individuals","NR","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-?","rs1800562",0,1800562,"missense",0,"NR",5e-11,10.3010299956639,"(Tf)",0.51,"[0.36-0.66] ng/ml decrease","Illumina [343,866]","N"]
["V5 (down-regulated)","08/22/2011",21743467,"Kote-Jarai Z","07/10/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21743467","Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.","Prostate cancer","6,621 European ancestry cases, 6,939 European ancestry controls","22,957 European ancestry cases, 23,234 European ancestry controls, 285 Japanese cases, 298 Japanese controls, 135 Chinese cases, 135 Chinese controls, 112 African American cases, 298 African American controls, 7,140 cases, 5,455 controls","12q13.12",12,49676010,"PRPH",null,84790,5630,null,8.9,12.9,"rs10875943-C","rs10875943",0,10875943,null,1,0.31,7e-12,11.1549019599857,null,1.07,"[1.04-1.10] ","NR [2.6 million] (imputed)","N"]
["V5 (down-regulated)","08/03/2011",21750679,"Allanore Y","07/07/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21750679","Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.","Systemic sclerosis","564 European ancestry cases, 1,776 European ancestry controls","1,682 European ancestry cases, 3,926 European ancestry controls","2p24.1",2,20688519,"RHOB",null,388,100271101,null,39.32,117.52,"rs13021401-T","rs13021401",0,13021401,null,1,0.23,3e-06,5.52287874528033,null,1.21,"[1.12-1.31] ","Illumina [489,814]","N"]
["V5 (down-regulated)","07/21/2011",21738478,"Okada Y","06/30/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21738478","Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.","White blood cell types","8,794 Japanese ancestry individuals","5,998 Japanese ancestry individuals","3q21.3",3,128316435,"GATA2",null,23434,6184,null,21.51,22.38,"rs4328821-A","rs4328821",0,4328821,null,1,0.66,5e-40,39.3010299956639,"(basophil count)",0.16,"[0.14-0.18] unit increase","Illumina [2,178,645] (imputed)","N"]
["V5 (down-regulated)","07/21/2011",21738478,"Okada Y","06/30/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21738478","Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.","White blood cell types","8,794 Japanese ancestry individuals","5,998 Japanese ancestry individuals","3q21.3",3,128316435,"GATA2",null,23434,6184,null,21.51,22.38,"rs4328821-A","rs4328821",0,4328821,null,1,0.66,3e-17,16.5228787452803,"(eosinophil count)",0.1,"[0.08-0.12] unit increase","Illumina [2,178,645] (imputed)","N"]
["V5 (down-regulated)","07/14/2011",21703634,"Wang KS","06/22/2011","J Psychiatr Res","http://www.ncbi.nlm.nih.gov/pubmed/21703634","A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.","Alcohol dependence","1,283 European ancestry cases, 1,416 European ancestry controls","3,334 European ancestry individuals from 778 nuclear families","11q24.2",11,125172593,"PKNOX2","- ",null,null,63876,null,null,"rs750338-C","rs750338",0,750338,"intron",0,0.22,1e-06,5.99999999999999,null,"NR","NR","Illumina [ (up-regulated) to 818,773]","N"]
["V5 (down-regulated)","07/20/2011",21658281,"Aouizerat BE","06/10/2011","BMC Cardiovasc Disord","http://www.ncbi.nlm.nih.gov/pubmed/21658281","GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.","Sudden cardiac arrest","89 European ancestry cases, 520 European ancestry controls","NR","6q25.1",6,152285687,"ESR1","- ",null,null,2099,null,null,"rs2982694-?","rs2982694",0,2982694,"intron",0,0.14,7e-10,9.15490195998574,"(Recessive)",1.43,"[1.28-1.60] ","Affymetrix [319,222]","N"]
["V5 (down-regulated)","07/07/2011",21665994,"Kutalik Z","06/10/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21665994","Genome-wide association study identifies two loci strongly affecting transferrin glycosylation.","Alcohol consumption","5,181 European ancestry individuals","2,284 European ancestry individauls","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-A","rs1800562",0,1800562,"missense",0,0.045,2e-32,31.698970004336,"(Total transferrin)",0.63,"[0.53-0.73] unit decrease","Affymetrix [390,631] (imputed)","N"]
["V5 (down-regulated)","06/16/2011",21642993,"Wu C","06/05/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21642993","Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.","Esophageal cancer","2,031 Han Chinese cases, 2,044 Han Chinese controls","3,986 Han Chinese cases, 4,157 Han Chinese controls","21q22.12",21,36357861,"RUNX1","- ",null,null,861,null,null,"rs2014300-G","rs2014300",0,2014300,"intron",0,0.83,8e-22,21.096910013008,null,1.43,"[1.33-1.54] ","Affymetrix [666,141]","N"]
["V5 (down-regulated)","06/16/2011",21626137,"Slavin TP","05/28/2011","Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/21626137","Two-marker association tests yield new disease associations for coronary artery disease and hypertension.","Coronary heart disease","~2,000 European ancestry cases, ~3,000 European ancestry controls","NR","4p16.2[rs7697839]; 4p16.2[rs7673097]",null,null,"STK32B","- ",{"$nulls":5},"2-SNP haplotype-3","rs7697839, rs7673097",{"$nulls":4},"(GG)",2e-11,null,"(Coronary artery disease)","NR","NR","Affymetrix [407,576]","N"]
["V5 (down-regulated)","07/13/2011",21572416,"Kato N","05/15/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21572416","Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.","Blood pressure","17,089 East Asian ancestry individuals, 2,519 Malay ancestry individuals","30,765 East Asian ancestry individuals","12q21.33",12,90060586,"ATP2B1",null,490,347894,null,10.74,86.1,"rs17249754-G","rs17249754",0,17249754,null,1,0.64,2e-13,12.698970004336,"(Diastolic)",0.58,"[0.42-0.74] mm Hg increase","Affymetrix & Illumina [1.7 million] (imputed)","N"]
["V5 (down-regulated)","07/13/2011",21572416,"Kato N","05/15/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21572416","Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.","Blood pressure","17,089 East Asian ancestry individuals, 2,519 Malay ancestry individuals","30,765 East Asian ancestry individuals","12q21.33",12,90060586,"ATP2B1",null,490,347894,null,10.74,86.1,"rs17249754-G","rs17249754",0,17249754,null,1,0.64,8e-20,19.096910013008,"(Systolic)",1.17,"[0.92-1.42] mm Hg increase","Affymetrix & Illumina [1.7 million] (imputed)","N"]
["V5 (down-regulated)","05/27/2011",21546767,"Murea M","05/05/2011","Am J Nephrol","http://www.ncbi.nlm.nih.gov/pubmed/21546767","Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.","Dialysis-related mortality","610 African American type 2 diabetics","NR","1p22.1",1,94462769,"ABCA4","- ",null,null,24,null,null,"rs17110736-?","rs17110736",0,17110736,"intron",0,0.35,5e-06,5.30102999566398,null,2.08,"[1.52-2.86] ","Affymetrix [832,357]","N"]
["V5 (down-regulated)","06/01/2011",21540461,"Kim DH","05/03/2011","Blood","http://www.ncbi.nlm.nih.gov/pubmed/21540461","A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia.","Chronic myeloid leukemia","201 Korean ancestry cases, 497 Korean ancestry controls","237 Korean ancestry cases, 1,000 Korean ancestry controls, 232 European ancestry cases, 576 European ancestry controls","6q25.1",6,151907748,"MTHFD1L, AKAP12, ZBTB2, RMND1, C6orf211, C6orf97, ESR1","- ",null,null,80129,null,null,"rs4869742-T","rs4869742",0,4869742,"intron",0,0.77,2e-06,5.69897000433601,null,1.67,"[1.35-2.04] ","Affymetrix [456,522]","N"]
["V5 (down-regulated)","06/01/2011",21507922,"Ramsuran V","05/01/2011","Clin Infect Dis","http://www.ncbi.nlm.nih.gov/pubmed/21507922","Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.","Platelet counts","115 African ancestry HIV-negative individuals","NR","1p34.2",1,41239511,"NFYC",null,407031,163732,null,16.47,87.22,"rs4660456-?","rs4660456",0,4660456,null,1,"NR",4e-06,5.39794000867203,null,"NR","NR","Illumina [874,956]","N"]
["V5 (down-regulated)","05/28/2011",21552555,"Wang K","04/28/2011","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/21552555","A genome-wide association study on obesity and obesity-related traits.","Obesity","520 European ancestry cases, 540 European ancestry controls","1,196 non-Hispanic Caucasian individuals","16q23.1",16,78952439,"WWOX","- ",null,null,51741,null,null,"rs9923451-?","rs9923451",0,9923451,"intron",0,"NR",8e-07,6.09691001300805,"(HIP)","NR","NR","Illumina [~550,000]","N"]
["V5 (down-regulated)","05/25/2011",21502573,"Smith NL","04/21/2011","Circulation","http://www.ncbi.nlm.nih.gov/pubmed/21502573","Genetic predictors of fibrin D-dimer levels in healthy adults.","D-dimer levels","21,052 European ancestry individuals","NR","1p22.1",1,94611300,"ABCA4, ARHGAP29",null,24,9411,null,24.6,23.16,"rs2774920-G","rs2774920",0,2774920,null,1,0.085,1e-06,5.99999999999999,null,0.05,"[NR] % increase","Affymetrix & Illumina [2,522,393] (imputed)","N"]
["V5 (down-regulated)","05/26/2011",21533175,"Zhai G","04/14/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21533175","Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.","Dehydroepiandrosterone sulphate levels","14,846 European ancestry individuals","NR","10q23.33",10,96751270,"CYP2C9",null,1559,100874505,null,2.12,15.89,"rs2185570-C","rs2185570",0,2185570,null,1,0.13,2e-08,7.69897000433601,null,0.06,"[0.04-0.08] u mol/L decrease","Affymetrix & Illumina [~2.5 million](imputed)","N"]
["V5 (down-regulated)","05/02/2011",21460842,"Cha PC","04/03/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21460842","A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids.","Uterine fibroids","1,607 Japanese ancestry cases, 1,428 Japanese ancestry controls","3,439 Japanese ancestry cases, 3,244 Japanese ancestry controls","10q24.33",10,105714399,"SLK, OBFC1",null,79991,9748,null,36.35,13.07,"rs7913069-A","rs7913069",0,7913069,null,1,0.07,9e-14,13.0457574905606,null,1.47,"[1.23-1.75] ","Illumina [457,044]","N"]
["V5 (down-regulated)","04/24/2013",21483845,"McLaren CE","03/31/2011","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/21483845","Genome-wide association study identifies genetic loci associated with iron deficiency.","Iron status biomarkers","336 European ancestry iron deficiency cases, 343 European ancestry controls","71 European ancestry iron deficiency cases, 161 European ancestry controls","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-A","rs1800562",0,1800562,"missense",0,"NR",6e-10,9.22184874961635,"(Unsaturated iron-binding capacity)",44.27,"[NR] ug/dL decrease","Illumina [331,060]","N"]
["V5 (down-regulated)","04/24/2013",21483845,"McLaren CE","03/31/2011","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/21483845","Genome-wide association study identifies genetic loci associated with iron deficiency.","Iron status biomarkers","336 European ancestry iron deficiency cases, 343 European ancestry controls","71 European ancestry iron deficiency cases, 161 European ancestry controls","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-A","rs1800562",0,1800562,"missense",0,"NR",3e-08,7.52287874528033,"(Total iorn-binding capacity)",35.36,"[NR] ug/dL decrease","Illumina [331,060]","N"]
["V5 (down-regulated)","04/11/2011",21423719,"Speliotes EK","03/10/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21423719","Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.","Nonalcoholic fatty liver disease","7,176 European ancestry individuals","592 European ancestry cases, 1,405 European ancestry controls","22q13.31",22,44324727,"PNPLA3","- ",null,null,80339,null,null,"rs738409-G","rs738409",0,738409,"missense",0,0.23,4e-34,33.397940008672,null,0.26,"[0.22-0.30] unit increase (GOLD)","Affymetrix & Illumina [~2.4 million] (imputed)","N"]
["V5 (down-regulated)","04/11/2011",21378990,"Schunkert H","03/06/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21378990","Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.","Coronary heart disease","22,233 European ancestry cases, 64,762 European ancestry controls","28,834 cases, 27,674 controls, 2,115 individuals.","10q11.21",10,44775824,"CXCL12",null,100506835,6387,null,384.94,89.78,"rs1746048-C","rs1746048",0,1746048,null,1,0.87,3e-10,9.52287874528033,null,1.09,"[1.07-1.13] ","Affymetrix & Illumina {~2.3 million] (imputed)","N"]
["V5 (down-regulated)","04/11/2011",21378990,"Schunkert H","03/06/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21378990","Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.","Coronary heart disease","22,233 European ancestry cases, 64,762 European ancestry controls","28,834 cases, 27,674 controls, 2,115 individuals.","1p32.2",1,56962821,"PPAP2B","- ",null,null,8613,null,null,"rs17114036-A","rs17114036",0,17114036,"intron",0,0.91,4e-19,18.397940008672,null,1.17,"[1.13-1.22] ","Affymetrix & Illumina {~2.3 million] (imputed)","N"]
["V5 (down-regulated)","04/11/2011",21378988,"The Coronary Artery Disease (C4D) Genetics Consortium","03/06/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21378988","A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.","Coronary heart disease","8,424 European ancestry cases, 7,268 European ancestry controls, 6,996 South Asian cases, 7,794 South Asian controls","18,049 European ancestry cases, 16,357 European ancestry controls, 3,359 South Asian cases, 2,828 South Asian controls","1p32.2",1,56966350,"PPAP2B","- ",null,null,8613,null,null,"rs17114046-?","rs17114046",0,17114046,"intron",0,"NR",2e-07,6.69897000433601,null,"NR","NR","Illumina [574,919]","N"]
["V5 (down-regulated)","04/04/2011",21326311,"Bhatnagar P","02/17/2011","J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/21326311","Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.","F-cell distribution","440 African ancestry individuals","NR","Xp22.11",23,22160992,"PHEX","- ",null,null,5251,null,null,"rs12559632-A","rs12559632",0,12559632,"intron",0,0.25,3e-06,5.52287874528033,null,1.16,"[0.69-1.63] unit decrease","Illumina [660,740]","N"]
["V5 (down-regulated)","04/07/2011",21347282,"Lettre G","02/10/2011","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/21347282","Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.","Coronary heart disease","8,090 African American individuals","8,849 African American or African-Caribbean individuals","10q25.2",10,114754088,"TCF7L2","- ",null,null,6934,null,null,"rs7901695-?","rs7901695",0,7901695,"intron",0,0.45,1e-06,5.99999999999999,"(T2D)",1.19,"[1.11-1.28] ","Affymetrix [~2.74 million] (imputed)","N"]
["V5 (down-regulated)","03/29/2011",21297633,"Anderson CA","02/06/2011","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21297633","Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.","Ulcerative colitis","6,687 European ancestry cases, 19,718 European ancestry controls","9,628 European ancestry cases, 12,917 European ancestry controls","9q32",9,117553249,"TNFSF8, TNFSF15","- ",null,null,9966,null,null,"rs4246905-C","rs4246905",0,4246905,"intron",0,0.71,6e-12,11.2218487496163,null,1.1,"[1.05-1.15] ","Affymetrix & Illumina [~1.1 million] (imputed)","N"]
["V5 (down-regulated)","03/28/2011",21348951,"Parsa A","02/01/2011","Clin Transl Sci","http://www.ncbi.nlm.nih.gov/pubmed/21348951","Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.","Cardiac hypertrophy","851 Old Order Amish individuals",null,"1p34.2",1,43596384,"SLC2A1",null,440584,440585,null,147.36,17.21,"rs16830359-?","rs16830359",0,16830359,null,1,"NR",1e-07,7,"(additive, recessive)","NR","NR","Affymetrix [361,034]","N"]
["V5 (down-regulated)","01/20/2012",21298047,"Chen X","01/27/2011","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/21298047","The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.","Substance dependence","2,524 individuals of European ancestry, 1,103 individuals of African ancestry","NR","11q24.2",11,125179853,"PKNOX2","- ",null,null,63876,null,null,"rs12284594-G","rs12284594",0,12284594,"intron",0,"NR",7e-08,7.15490195998574,"(European women)",1.77,"[NR] ","Illumina [830,696]","N"]
["V5 (down-regulated)","03/04/2011",21263130,"Fletcher O","01/24/2011","J Natl Cancer Inst","http://www.ncbi.nlm.nih.gov/pubmed/21263130","Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.","Breast cancer","1,694 British cases, 2,365 British controls, 1,145 European ancestry cases, 1,142 European ancestry controls","7,317 British cases, 8,124 British controls","6q25.1",6,151939350,"ESR1","- ",null,null,80129,null,null,"rs3734805-C","rs3734805",0,3734805,"UTR-3",0,0.08,1e-07,7,null,1.19,"[1.11-1.27] ","Illumina [~296,114]","N"]
["V5 (down-regulated)","02/22/2011",21216879,"Kaplan RC","01/07/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21216879","A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3.","Insulin-like growth factors","10,280 European ancestry individuals","NR","6q21",6,108988184,"FOXO3","- ",null,null,2309,null,null,"rs2153960-A","rs2153960",0,2153960,"intron",0,0.69,5e-07,6.30102999566398,"(IGF-I)","NR","NR","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","02/03/2011",21208937,"Pichler I","01/04/2011","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21208937","Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels.","Iron levels"," (up-regulated) to 5,633 Caucasian individuals"," (up-regulated) to 3,457 Caucasian individuals","6p22.2",6,26091179,"HFE","- ",null,null,3077,null,null,"rs1799945-C","rs1799945",0,1799945,"missense",0,0.83,3e-09,8.52287874528033,"(iron)",4.95,"[3.30-6.60] ug/dl decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","01/15/2011",21149283,"Oexle K","12/10/2010","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21149283","Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels.","Iron status biomarkers"," (up-regulated) to 6,616 individuals","NR","6p22.2",6,25842951,"HFE",null,6568,10786,null,10.66,2.38,"rs1408272-T","rs1408272",0,1408272,null,1,"NR",9e-09,8.04575749056067,"(sTfR)",0.04,"[0.03-0.05] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","01/15/2011",21149283,"Oexle K","12/10/2010","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/21149283","Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels.","Iron status biomarkers"," (up-regulated) to 6,616 individuals","NR","6p22.2",6,25821770,"HFE","- ",null,null,6568,null,null,"rs17342717-T","rs17342717",0,17342717,"intron",0,"NR",9e-10,9.04575749056067,"(ferritin)",0.09,"[0.06-0.12] unit increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","01/08/2011",21107309,"McClay JL","11/24/2010","Neuropsychopharmacology","http://www.ncbi.nlm.nih.gov/pubmed/21107309","Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.","Reasoning","738 schizophrenia cases","NR","16q23.1",16,78569957,"WWOX","- ",null,null,51741,null,null,"rs17706989-?","rs17706989",0,17706989,"intron",0,0.03,1e-06,5.99999999999999,"(olanzapine)","NR","NR","Affymetrix [492,900]","N"]
["V5 (down-regulated)","01/08/2011",21102462,"Elks CE","11/21/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21102462","Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.","Menarche (age at onset)","87,802 European ancestry women"," (up-regulated) to 14,731 women","19p13.11",19,18817903,"CRTC1","- ",null,null,23373,null,null,"rs10423674-A","rs10423674",0,10423674,"intron",0,0.35,6e-09,8.22184874961635,null,2.3,"[1.52-3.08] week decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","10/19/2012",21102463,"Franke A","11/21/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21102463","Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.","Crohn's disease","6,333 European ancestry cases, 15,056 European ancestry controls","15,694 European ancestry cases, 14,026 European ancestry controls, 414 European ancestry parent-offspring trios","14q24.1",14,69210199,"ZFP36L1",null,326275,677,null,49.86,44.17,"rs4902642-G","rs4902642",0,4902642,null,1,0.584,2e-10,9.69897000433601,null,1.07,"[1.11-1.04] ","Affymetrix & Illumina [953,241] (imputed)","N"]
["V5 (down-regulated)","10/19/2012",21102463,"Franke A","11/21/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21102463","Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.","Crohn's disease","6,333 European ancestry cases, 15,056 European ancestry controls","15,694 European ancestry cases, 14,026 European ancestry controls, 414 European ancestry parent-offspring trios","9q32",9,117552885,"TNFSF15,TNFSF8","- ",null,null,9966,null,null,"rs3810936-C","rs3810936",0,3810936,"cds-synon",0,0.682,1e-15,15,null,1.21,"[1.15-1.27] ","Affymetrix & Illumina [953,241] (imputed)","N"]
["V5 (down-regulated)","10/19/2012",21102463,"Franke A","11/21/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21102463","Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.","Crohn's disease","6,333 European ancestry cases, 15,056 European ancestry controls","15,694 European ancestry cases, 14,026 European ancestry controls, 414 European ancestry parent-offspring trios","1p36.23",1,7879063,"VAMP3","- ",null,null,8863,null,null,"rs2797685-A","rs2797685",0,2797685,"intron",0,0.19,7e-09,8.15490195998574,null,1.05,"[1.01-1.10] ","Affymetrix & Illumina [953,241] (imputed)","N"]
["V5 (down-regulated)","01/06/2011",21076409,"Sotoodehnia N","11/14/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21076409","Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.","Ventricular conduction","40,407 European ancestry individuals","7,170 European ancestry individuals","3p21.1",3,53282303,"TKT, PRKCD, CACNA1D","- ",null,null,7086,null,null,"rs4687718-A","rs4687718",0,4687718,"intron",0,0.14,6e-09,8.22184874961635,null,0.63,"[0.41-0.85] ms decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","01/06/2011",21076409,"Sotoodehnia N","11/14/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/21076409","Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.","Ventricular conduction","40,407 European ancestry individuals","7,170 European ancestry individuals","17q24.2",17,64318357,"PRKCA","- ",null,null,5578,null,null,"rs9912468-G","rs9912468",0,9912468,"intron",0,0.43,1e-08,8,null,0.39,"[0.25-0.53] ms increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","01/11/2011",21057379,"Curtis D","11/04/2010","Psychiatr Genet","http://www.ncbi.nlm.nih.gov/pubmed/21057379","Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes.","Bipolar disorder and schizophrenia","506 European bipolar 1 disorder cases, 523 European schizophrenia cases, 505 European controls","NR","7q36.3",7,157510195,"PTPRN2","- ",null,null,5799,null,null,"rs6459804-?","rs6459804",0,6459804,"intron",0,"NR",8e-06,5.09691001300805,null,"NR","NR","Affymetrix [302,482]","N"]
["V5 (down-regulated)","11/17/2010",20935629,"Heid IM","10/10/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20935629","Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.","Waist-hip ratio"," (up-regulated) to 77,167 European descent individuals"," (up-regulated) to 113,636 European descent individuals","1q24.3",1,172346548,"DNM3, PIGC","- ",null,null,"26052;100505991",null,null,"rs1011731-G","rs1011731",0,1011731,"intron;intron",0,0.57,1e-17,17,null,0.03,"[NR] unit increase","Affymetrix, Illumina & Perlegen [ (up-regulated) to 2,850,269](imputed)","N"]
["V5 (down-regulated)","11/23/2010",20923822,"Niu N","10/05/2010","Genome Res","http://www.ncbi.nlm.nih.gov/pubmed/20923822","Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.","Radiation response","Human lymphoblastoid cell lines from 93 African Americans, 89 Caucasian-Americans, and 95 Han Chinese Americans","NR","16q23.1",16,78631794,"WWOX","- ",null,null,51741,null,null,"rs2859631-?","rs2859631",0,2859631,"intron",0,0.07,1e-06,5.99999999999999,null,"NR","NR","Affymetrix & Illumina [1,348,798]","N"]
["V5 (down-regulated)","11/02/2012",20889312,"Wang KS","10/01/2010","Schizophr Res","http://www.ncbi.nlm.nih.gov/pubmed/20889312","A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.","Bipolar disorder and schizophrenia","651 European American bipolar cases, 1,171 European American schizophrenia cases, 2,412 European American controls","NR","8q12.1",8,58840924,"FAM110B",null,100270982,90362,null,535.48,66.19,"rs1992045-?","rs1992045",0,1992045,null,1,"NR",2e-07,6.69897000433601,null,1.56,"[NR] ","Affymetrix [722,112]","N"]
["V5 (down-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","5q34",5,168256240,"SLIT3","- ",null,null,6586,null,null,"rs4282339-A","rs4282339",0,4282339,"intron",0,0.2,7e-16,15.1549019599857,null,0.04,"[NR] unit decrease","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V5 (down-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","6p24.3",6,7725760,"BMP6","- ",null,null,654,null,null,"rs3812163-A","rs3812163",0,3812163,"nearGene-5",0,0.54,1e-23,23,null,0.04,"[NR] unit decrease","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V5 (down-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","6q25.1",6,152110943,"ESR1","- ",null,null,2099,null,null,"rs543650-T","rs543650",0,543650,"intron",0,0.4,1e-17,17,null,0.03,"[NR] unit decrease","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V5 (down-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","6p22.3",6,19841493,"ID4","- ",null,null,3400,null,null,"rs1047014-T","rs1047014",0,1047014,"UTR-3",0,0.75,2e-13,12.698970004336,null,0.03,"[NR] unit decrease","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V5 (down-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","2q35",2,218271898,"TNS1","- ",null,null,729582,null,null,"rs1351164-T","rs1351164",0,1351164,"intron",0,0.79,2e-14,13.698970004336,null,0.03,"[NR] unit increase","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V5 (down-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","17q23.2",17,59496649,"TBX2",null,6909,9496,null,9.82,37.16,"rs2079795-T","rs2079795",0,2079795,null,1,0.33,2e-24,23.698970004336,null,0.04,"[NR] unit increase","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V5 (down-regulated)","10/24/2012",20881960,"Lango Allen H","09/29/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20881960","Hundreds of variants clustered in genomic loci and biological pathways affect human height.","Height","133,653 European ancestry individuals","50,074 European ancestry individuals","15q23",15,70048157,"TLE3",null,6176,100128431,null,300.27,47.3,"rs10152591-A","rs10152591",0,10152591,null,1,0.91,3e-10,9.52287874528033,null,0.04,"[NR] unit increase","Affymetrix,  Illumina [2,834,208] (imputed)","N"]
["V5 (down-regulated)","10/15/2010",20927387,"Kullo IJ","09/28/2010","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/20927387","A genome-wide association study of red blood cell traits using the electronic medical record.","Red blood cell traits","3,012 European ancestry individuals","NR","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-A","rs1800562",0,1800562,"missense",0,0.06,3e-09,8.52287874528033,"(MCH)",0.49,"[NR] unit increase","Illumina [489,421]","N"]
["V5 (down-regulated)","10/15/2010",20927387,"Kullo IJ","09/28/2010","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/20927387","A genome-wide association study of red blood cell traits using the electronic medical record.","Red blood cell traits","3,012 European ancestry individuals","NR","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-A","rs1800562",0,1800562,"missense",0,0.06,3e-09,8.52287874528033,"(MCH)",0.49,"[0.33-0.65] unit increase","Illumina [489,421]","N"]
["V5 (down-regulated)","10/15/2010",20927387,"Kullo IJ","09/28/2010","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/20927387","A genome-wide association study of red blood cell traits using the electronic medical record.","Red blood cell traits","3,012 European ancestry individuals","NR","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-A","rs1800562",0,1800562,"missense",0,0.06,6e-07,6.22184874961635,"(MCV)",1.09,"[NR] unit increase","Illumina [489,421]","N"]
["V5 (down-regulated)","10/17/2010",20864672,"Waterworth DM","09/23/2010","Arterioscler Thromb Vasc Biol","http://www.ncbi.nlm.nih.gov/pubmed/20864672","Genetic variants influencing circulating lipid levels and risk of coronary artery disease.","HDL cholesterol"," (up-regulated) to 17,243 white European descent individuals"," (up-regulated) to 37,774 white European descent individuals,  (up-regulated) to 9,665 Indian Asian individuals","12q24.11",12,109840940,"MYO1H,KCTD10,UBE3B,MMAB,MVK","- ",null,null,283446,null,null,"rs9943753-G","rs9943753",0,9943753,"intron",0,0.63,3e-06,5.52287874528033,null,0.02,"[0.01-0.03] unit increase","Affymetrix, Illumina & Perlegen [2,155,369] (imputed)","N"]
["V5 (down-regulated)","10/07/2010",20858683,"Soranzo N","09/21/2010","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/20858683","Common variants at 10 genomic loci influence hemoglobin A&#x02081;(C) levels via glycemic and nonglycemic pathways.","Glycated hemoglobin levels"," (up-regulated) to 46,368 European ancestry individuals","NR","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-G","rs1800562",0,1800562,"missense",0,0.94,3e-20,19.5228787452803,null,0.06,"[0.05-0.07] % increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","10/07/2010",20858683,"Soranzo N","09/21/2010","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/20858683","Common variants at 10 genomic loci influence hemoglobin A&#x02081;(C) levels via glycemic and nonglycemic pathways.","Glycated hemoglobin levels"," (up-regulated) to 46,368 European ancestry individuals","NR","10q22.1",10,71093392,"HK1","- ",null,null,3098,null,null,"rs16926246-C","rs16926246",0,16926246,"intron",0,0.9,3e-54,53.5228787452803,null,0.09,"[0.08-0.10] % increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","10/05/2010",20849430,"Franklin CS","09/16/2010","Ann Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/20849430","The TCF7L2 diabetes risk variant is associated with HbA&#x02081;(C) levels: a genome-wide association meta-analysis.","Glycated hemoglobin levels","1,782 non-diabetic Scottish and Croatian individuals","NR","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-C","rs7903146",0,7903146,"intron",0,0.72,1e-07,7,null,0.05,"[0.02-0.08] % HbA1C decrease","Illumina [256,587]","N"]
["V5 (down-regulated)","10/05/2010",20833655,"Cha PC","09/10/2010","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/20833655","Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese.","Warfarin maintenance dose","807 low dose Japanese, 707 high dose Japanese","444 individuals","10q23.33",10,96734339,"CYP2C9","- ",null,null,1559,null,null,"rs10509680-?","rs10509680",0,10509680,"intron",0,"NR",4e-07,6.39794000867203,null,"NR","NR","Illumina [485,227]","N"]
["V5 (down-regulated)","09/15/2010",20700443,"Meyer TE","08/05/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20700443","Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels.","Magnesium levels","15,366 European descent individuals","8,463 European descent individuals","12q21.33",12,90305779,"ATP2B1",null,347894,439916,null,158.15,1006.02,"rs7965584-G","rs7965584",0,7965584,null,1,0.29,1e-16,16,null,0.07,"[0.005-0.009] mmol/L decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","Cholesterol, total"," (up-regulated) to 100,184 European descent individuals",null,"6p22.2",6,26093141,"HFE,HIST1H4C","- ",null,null,3077,null,null,"rs1800562-A","rs1800562",0,1800562,"missense",0,0.06,2e-08,7.69897000433601,null,2.16,"[1.32-3] mg/dL decrease","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V5 (down-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","Cholesterol, total"," (up-regulated) to 100,184 European descent individuals",null,"11q24.2",11,126243952,"ST3GAL4","- ",null,null,6484,null,null,"rs11220462-T ","rs11220462",0,11220462,"intron",0,0.11,2e-11,10.698970004336,null,2.01,"[1.36-2.66] mg/dL increase","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V5 (down-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","LDL cholesterol"," (up-regulated) to 95,454 European descent individuals",null,"11q24.2",11,126243952,"ST3GAL4","- ",null,null,6484,null,null,"rs11220462-A","rs11220462",0,11220462,"intron",0,0.14,1e-15,15,null,1.95,"[1.44-2.46] mg/dL increase","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V5 (down-regulated)","01/25/2012",20686565,"Teslovich TM","08/05/2010","Nature","http://www.ncbi.nlm.nih.gov/pubmed/20686565","Biological, clinical and population relevance of 95 loci for blood lipids.","LDL cholesterol"," (up-regulated) to 95,454 European descent individuals",null,"6p22.2",6,26093141,"HFE,HIST1H4C","- ",null,null,3077,null,null,"rs1800562-A","rs1800562",0,1800562,"missense",0,0.06,6e-10,9.22184874961635,null,2.22,"[1.46-2.98] mg/dL decrease","Affymetrix, Illumina & Perlegen [~2.6 million] (imputed)","N"]
["V5 (down-regulated)","09/13/2010",20694148,"Zabaneh D","08/04/2010","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/20694148","A genome-wide association study of the metabolic syndrome in Indian Asian men.","Metabolic syndrome","2,554 Indian Asian men","2,240 Indian Asian men","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-A","rs7903146",0,7903146,"intron",0,0.3,7e-07,6.15490195998574,"(T2D)",1.33,"[1.19-1.49] ","Illumina [308,011]","N"]
["V5 (down-regulated)","07/12/2010",20581827,"Voight BF","06/27/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20581827","Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.","Type 2 diabetes","8,130 European ancestry cases, 38,987 European ancestry controls"," (up-regulated) to 34,412 European ancestry cases, 59,925 European ancestry controls","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-T","rs7903146",0,7903146,"intron",0,"NR",2e-51,50.698970004336,null,1.4,"[1.34-1.46] ","Affymetrix & Illumina [2,426,886] (imputed)","N"]
["V5 (down-regulated)","06/09/2010",20460270,"Garcia-Barcelo MM","05/11/2010","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/20460270","Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2.","Biliary atresia","200 Chinese cases, 481 Chinese controls","124 Chinese cases, 90 Chinese controls","13q12.3",13,30458737,"UBL3","- ",null,null,100874059,null,null,"rs9314986-G","rs9314986",0,9314986,"intron",0,0.044,2e-06,5.69897000433601,null,2.95,"[1.89-4.60] ","Affymetrix [289,118]","N"]
["V5 (down-regulated)","06/02/2010",20453838,"Turnbull C","05/09/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20453838","Genome-wide association study identifies five new breast cancer susceptibility loci.","Breast cancer","3,659 UK cases, 4,897 UK controls","12,576 European cases, 12,223 European controls","6q25.1",6,151914113,"ESR1,C6orf97","- ",null,null,80129,null,null,"rs3757318-A","rs3757318",0,3757318,"intron",0,0.07,3e-06,5.52287874528033,null,1.3,"[1.17-1.46] ","Illumina [582,886]","N"]
["V5 (down-regulated)","05/25/2010",20421499,"Levy D","04/26/2010","Proc Natl Acad Sci U S A","http://www.ncbi.nlm.nih.gov/pubmed/20421499","Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology.","Telomere length","3,417 European ancestry individuals","1,893 African American and white individuals, 2,876 British women","10q24.33",10,105677897,"OBFC1","- ",null,null,79991,null,null,"rs4387287-A","rs4387287",0,4387287,"UTR-5",0,"NR",2e-11,10.698970004336,null,0.1,"[0.06-0.14] kb increase","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","05/05/2010",20383145,"Chambers JC","04/11/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20383145","Genetic loci influencing kidney function and chronic kidney disease.","Creatinine levels","23,812 European descent individuals","16,626 European individuals","17q23.2",17,59483766,"TBX2","- ",null,null,6909,null,null,"rs8068318-G","rs8068318",0,8068318,"intron",0,0.27,3e-10,9.52287874528033,null,0.8,"[0.6-1.0] % increase","Affymetrix, Illumina and Perlegen [~2.6 Million] (imputed)","N"]
["V5 (down-regulated)","05/05/2010",20383146,"Kottgen A","04/11/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20383146","New loci associated with kidney function and chronic kidney disease.","Chronic kidney disease"," (up-regulated) to 67,093 European ancestry individuals"," (up-regulated) to 22,982 European ancestry individuals","17q23.2",17,59456589,"BCAS3,TBX2,C17orf82","- ",null,null,54828,null,null,"rs9895661-C","rs9895661",0,9895661,"intron",0,0.19,1e-15,15,"(eGFRcrea)",0.01,"[0.007-0.015] ml/min/1.73 m2 decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","04/14/2010",20339536,"Barber MJ","03/22/2010","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/20339536","Genome-wide association of lipid-lowering response to statins in combined study populations.","Response to statin therapy","3,928 Caucasian individuals","NR","6p22.3",6,19969638,"LOC729105, ID4, MBOAT1",null,3400,645224,null,127.21,72.94,"rs16883019-C","rs16883019",0,16883019,null,1,0.04,7e-07,6.15490195998574,"(Triglyceride, sum)","NR","NR","Illumina [~2.5 million](imputed)","N"]
["V5 (down-regulated)","04/14/2010",20339536,"Barber MJ","03/22/2010","PLoS One","http://www.ncbi.nlm.nih.gov/pubmed/20339536","Genome-wide association of lipid-lowering response to statins in combined study populations.","Response to statin therapy","3,928 Caucasian individuals","NR","8p12",8,29360305,"LOC646909, DUSP4, KIF13B",null,1846,646909,null,152.04,129.27,"rs10091038-A","rs10091038",0,10091038,null,1,0.43,3e-08,7.52287874528033,"(HDL, sum)","NR","NR","Illumina [~2.5 million](imputed)","N"]
["V5 (down-regulated)","03/30/2010",20208534,"Rothenberg ME","03/07/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20208534","Common variants at 5q22 associate with pediatric eosinophilic esophagitis.","Eosinophilic esophagitis (pediatric)","181 European descent adolescent cases, 1,974 European descent adolescent controls","170 European descent cases, 1,130 European descent controls","12q13.3",12,57503775,"STAT6","- ",null,null,6778,null,null,"rs167769-T","rs167769",0,167769,"intron",0,0.37,2e-06,5.69897000433601,null,1.36,"[1.10-1.69] ","Illumina [~550,000]","N"]
["V5 (down-regulated)","03/29/2010",20190752,"Dubois PC","02/28/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20190752","Multiple common variants for celiac disease influencing immune gene expression.","Celiac disease","4,533 European descent cases, 10,750 European descent controls","4,918 European descent cases, 5,684 European descent controls","14q24.1",14,69278204,"ZFP36L1",null,677,90352,null,15.24,50.24,"rs4899260-A","rs4899260",0,4899260,null,1,0.26,4e-07,6.39794000867203,null,1.12,"[1.07-1.16] ","Illumina [292,387]","N"]
["V5 (down-regulated)","03/29/2010",20190752,"Dubois PC","02/28/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20190752","Multiple common variants for celiac disease influencing immune gene expression.","Celiac disease","4,533 European descent cases, 10,750 European descent controls","4,918 European descent cases, 5,684 European descent controls","11q24.3",11,128380974,"ETS1","- ",null,null,2113,null,null,"rs11221332-A","rs11221332",0,11221332,"intron",0,0.24,5e-16,15.3010299956639,null,1.21,"[1.16-1.27] ","Illumina [292,387]","N"]
["V5 (down-regulated)","03/06/2010",20169177,"Yang W","02/12/2010","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/20169177?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2","Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic l (up-regulated)us erythematosus.","Systemic l (up-regulated)us erythematosus","314 Chinese cases, 1,500 Chinese controls","2,630 Chinese cases, 2,155 Chinese controls, 314 Thai cases, 519 Thai controls","11q24.3",11,128328959,"ETS1","- ",null,null,2113,null,null,"rs1128334-A","rs1128334",0,1128334,"UTR-3",0,0.35,2e-11,10.698970004336,null,1.29,"[1.20-1.39] ","Illumina [514,221]","N"]
["V5 (down-regulated)","02/28/2010",20081858,"D (up-regulated)uis J","01/17/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20081858?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.","Fasting glucose-related traits"," (up-regulated) to 46,186 European descent individuals"," (up-regulated) to 76,558 European ancestry individuals","10q25.2",10,114756041,"TCF7L2","- ",null,null,6934,null,null,"rs4506565-T","rs4506565",0,4506565,"intron",0,0.31,1e-08,8,"(FPG)","NR","NR","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","02/08/2010",20081857,"Saxena R","01/17/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20081857?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=3","Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.","Two-hour glucose challenge","15,234 European individuals"," (up-regulated) to 30,620 European individuals","10q25.2",10,114788815,"TCF7L2","- ",null,null,6934,null,null,"rs12243326-C","rs12243326",0,12243326,"intron",0,"NR",1e-07,7,null,0.08,"[0.06-0.10] mmol/L increase","Affymetrix & Illumina [NR]","N"]
["V5 (down-regulated)","01/29/2010",20062061,"Chambers JC","01/10/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20062061?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2","Genetic variation in SCN10A influences cardiac conduction.","Electrocardiographic traits","6,543 Indian Asians","6,243 Indian Asians, 5,370 Europeans","7q36.1",7,150637863,"KCNH2",null,26,3757,null,79.48,4.18,"rs4725982-A","rs4725982",0,4725982,null,1,"NR",3e-06,5.52287874528033,"(QTc interval)",2.08,"[1.20-2.96] ms increase","Illumina [303,309]","N"]
["V5 (down-regulated)","02/02/2010",20062063,"Holm H","01/10/2010","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20062063?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2","Several common variants modulate heart rate, PR interval and QRS duration.","Electrocardiographic traits"," (up-regulated) to 12,670 Icelandic individuals"," (up-regulated) to 10,352 Icelandic individuals","7q36.1",7,150667210,"KCNH2","- ",null,null,3757,null,null,"rs3807375-T","rs3807375",0,3807375,"intron",0,0.35,5e-11,10.3010299956639,"(QT interval)",11.95,"[8.39-15.51] % s.d. increase","Illumina [306,060]","N"]
["V5 (down-regulated)","01/19/2010",20038947,"Shyn SI","12/29/2009","Mol Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/20038947?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.","Major depressive disorder (broad)","3,957 cases, 3,428 controls","NR","8p21.3",8,20066049,"ATP6V1B2, SLC18A1, LZTS1","- ",null,null,526,null,null,"rs1106634-A","rs1106634",0,1106634,"intron",0,0.14,7e-07,6.15490195998574,null,1.3,"[NR] ","Affymetrix and Perlegen [2,391,203] (imputed)","N"]
["V5 (down-regulated)","12/28/2009",20010834,"Repapi E","12/13/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/20010834?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Genome-wide association study identifies five loci associated with lung function.","Pulmonary function","20,288 European ancestry individuals"," (up-regulated) to 54,276 European ancestry individuals","2q35",2,218683154,"TNS1","- ",null,null,7145,null,null,"rs2571445-G","rs2571445",0,2571445,"missense",0,0.6,1e-12,12,"(FEV1)",0.07,"[NR] % variance explained","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","12/04/2009",19893584,"Kim JJ","11/06/2009","J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/19893584","Identification of 15 loci influencing height in a Korean population.","Height","8,842 Korean individuals","NR","17q23.2",17,59496649,"C17orf82, TBX2, TBX4",null,6909,9496,null,9.82,37.16,"rs2079795-T","rs2079795",0,2079795,null,1,0.33,3e-06,5.52287874528033,null,0.4,"[NR] cm increase","Affymetrix [334,546]","N"]
["V5 (down-regulated)","08/18/2010",19853236,"Ferreira MA","10/22/2009","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/19853236","Sequence variants in three loci influence monocyte counts and erythrocyte volume.","Hematology traits","2,538 Australian individuals, 3,477 Dutch individuals","1,543 Australian and European individuals","6p22.2",6,25842951,"HFE",null,6568,10786,null,10.66,2.38,"rs1408272-T","rs1408272",0,1408272,null,1,0.94,1e-11,11,"(MCH)",0.32,"[0.22-0.42] s.d. decrease","Illumina & Perlegen [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","11/09/2009",19838193,"Han JW","10/18/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19838193?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2","Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic l (up-regulated)us erythematosus.","Systemic l (up-regulated)us erythematosus","1,047 Chinese Han cases, 1,205 Chinese Han controls","3,152 Chinese Han cases, 7,050 Chinese Han controls","11q24.3",11,128311059,"ETS1",null,283165,2113,null,1435.11,17.6,"rs6590330-A","rs6590330",0,6590330,null,1,0.34,2e-25,24.698970004336,null,1.37,"[1.29-1.45)","Illumina [493,955]","N"]
["V5 (down-regulated)","11/05/2009",19820699,"Benyamin B","10/11/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19820699?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Common variants in TMPRSS6 are associated with iron status and erythrocyte volume.","Iron status biomarkers","4,818 Australian siblings","3,470 Dutch individuals","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-A","rs1800562",0,1800562,"missense",0,0.08,2e-08,7.69897000433601,"(MCV)",0.22,"[0.14-0.30] s.d. increase","Illumina & Perlegen [427,037]","N"]
["V5 (down-regulated)","11/05/2009",19820699,"Benyamin B","10/11/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19820699?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Common variants in TMPRSS6 are associated with iron status and erythrocyte volume.","Iron status biomarkers","4,818 Australian siblings","3,470 Dutch individuals","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-A","rs1800562",0,1800562,"missense",0,0.08,5e-07,6.30102999566398,"(Hgb)",0.2,"[0.12-0.28] s.d. increase","Illumina & Perlegen [427,037]","N"]
["V5 (down-regulated)","11/05/2009",19820698,"Chambers JC","10/11/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19820698?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels.","Hemoglobin","6,316 Europeans, 9,685 Indian Asians","5,187 Europeans, 6,721 Indian Asians","6p22.2",6,26107463,"HFE","- ",null,null,3010,null,null,"rs198846-A","rs198846",0,198846,"nearGene-3",0,"NR",1e-08,8,null,"NR","NR","Affymetrix, Illumina & Perlegen [NR]","N"]
["V5 (down-regulated)","11/03/2009",19862010,"Ganesh SK","10/11/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19862010?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.","Hematocrit","24,167 European ancestry individuals","9,456 European ancestry individuals","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-A","rs1800562",0,1800562,"missense",0,"NR",2e-09,8.69897000433601,null,0.31,"[0.21-0.41] % increase","Affymetrix & Illumina [~2.5 million](imputed)","N"]
["V5 (down-regulated)","11/03/2009",19862010,"Ganesh SK","10/11/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19862010?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.","Hematocrit","24,167 European ancestry individuals","9,456 European ancestry individuals","10q22.1",10,71093392,"HK1","- ",null,null,3098,null,null,"rs16926246-T","rs16926246",0,16926246,"intron",0,"NR",1e-13,13,null,0.33,"[0.24-0.42] % increase","Affymetrix & Illumina [~2.5 million](imputed)","N"]
["V5 (down-regulated)","11/03/2009",19862010,"Ganesh SK","10/11/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19862010?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.","Hematocrit","24,167 European ancestry individuals","9,456 European ancestry individuals","2p21",2,46360907,"PRKCE","- ",null,null,5581,null,null,"rs10168349-C","rs10168349",0,10168349,"intron",0,"NR",4e-15,14.397940008672,null,0.19,"[0.14-0.23] % increase","Affymetrix & Illumina [~2.5 million](imputed)","N"]
["V5 (down-regulated)","11/03/2009",19862010,"Ganesh SK","10/11/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19862010?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.","Hemoglobin","24,167 European ancestry individuals","9,456 European ancestry individuals","2p21",2,46353166,"PRKCE","- ",null,null,5581,null,null,"rs10495928-G","rs10495928",0,10495928,"intron",0,"NR",7e-13,12.1549019599857,null,0.06,"[0.05-0.08] g/dl increase","Affymetrix & Illumina [~2.5 million](imputed)","N"]
["V5 (down-regulated)","11/03/2009",19862010,"Ganesh SK","10/11/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19862010?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.","Hemoglobin","24,167 European ancestry individuals","9,456 European ancestry individuals","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-A","rs1800562",0,1800562,"missense",0,"NR",6e-19,18.2218487496163,null,0.16,"[0.13-0.20] g/dl increase","Affymetrix & Illumina [~2.5 million](imputed)","N"]
["V5 (down-regulated)","11/03/2009",19862010,"Ganesh SK","10/11/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19862010?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.","Hemoglobin","24,167 European ancestry individuals","9,456 European ancestry individuals","10q22.1",10,71093392,"HK1","- ",null,null,3098,null,null,"rs16926246-T","rs16926246",0,16926246,"intron",0,"NR",2e-11,10.698970004336,null,0.11,"[0.08-0.14] g/dl increase","Affymetrix & Illumina [~2.5 million](imputed)","N"]
["V5 (down-regulated)","11/03/2009",19862010,"Ganesh SK","10/11/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19862010?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1","Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.","Mean corpuscular volume","24,167 European ancestry individuals","9,456 European ancestry individuals","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-A","rs1800562",0,1800562,"missense",0,"NR",1e-46,45.9999999999999,null,0.01,"[0.010-0.014] fl increase","Affymetrix & Illumina [~2.5 million](imputed)","N"]
["V5 (down-regulated)","10/30/2009",19820697,"Soranzo N","10/11/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19820697?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.","Hematological parameters","4,627 European individuals","9,316 European individuals","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-A","rs1800562",0,1800562,"missense",0,"NR",1e-23,23,"(MCV)",1.41,"[1.13-1.69] fl increase","Affymetrix and Illumina [~2.11 million] (imputed)","N"]
["V5 (down-regulated)","10/16/2009",19801982,"Rivadeneira F","10/04/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19801982?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.","Bone mineral density (hip)","19,195 European individuals","NR","6q25.1",6,152009638,"ESR1","- ",null,null,2099,null,null,"rs2941740-G","rs2941740",0,2941740,"nearGene-5",0,0.43,2e-10,9.69897000433601,null,0.07,"[0.05-0.09] s.d. increase","Affymetrix & Illumina [2,543,686](imputed)","N"]
["V5 (down-regulated)","10/16/2009",19801982,"Rivadeneira F","10/04/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19801982?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.","Bone mineral density (spine)","19,195 European individuals","NR","6q25.1",6,152090707,"ESR1","- ",null,null,2099,null,null,"rs2504063-A","rs2504063",0,2504063,"intron",0,0.4,6e-11,10.2218487496163,null,0.08,"[0.06-0.10] s.d. decrease","Affymetrix & Illumina [2,543,686](imputed)","N"]
["V5 (down-regulated)","09/29/2009",19734900,"Rung J","09/06/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19734900?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.","Type 2 diabetes and other traits","679 French cases, 697 French controls","5,579 European cases, 7,096 European controls","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-T","rs7903146",0,7903146,"intron",0,0.27,1e-30,30,null,1.48,"[1.39-1.57] ","Illumina [392,365]","N"]
["V5 (down-regulated)","11/08/2012",19734545,"Need AC","09/04/2009","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19734545?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.","Cognitive performance"," (up-regulated) to 1,295 individuals","NR","11q13.5",11,76823484,"CAPN5","- ",null,null,726,null,null,"rs3781684-?","rs3781684",0,3781684,"intron",0,0.1135,7e-06,5.15490195998574,"(VRM)","NR","NR","Illumina [475,971]","N"]
["V5 (down-regulated)","09/09/2009",19706858,"Shuldiner AR","08/26/2009","JAMA","http://www.ncbi.nlm.nih.gov/pubmed/19706858","Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.","Response to clopidogrel therapy","429 Amish individuals","140 European ancestry individuals, 83 African American individuals, 4 individuals","10q23.33",10,96405502,"CYP2C18, CYP2C19, CYP2C9, CYP2C8",null,3070,1562,null,43.65,37.75,"rs12777823-?","rs12777823",0,12777823,null,1,0.17,2e-13,12.698970004336,"(Amish)","NR","NR","Affymetrix [400,230]","N"]
["V5 (down-regulated)","12/29/2009",20031604,"Cheng YC","08/01/2009","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/20031604?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2","Genome-wide association scan identifies variants near Matrix Metalloproteinase (MMP) genes on chromosome 11q21-22 strongly associated with serum MMP-1 levels.","Matrix metalloproteinase levels","778 Old Order Amish individuals","NR","20p11.23",20,19571581,"SLC24A3","- ",null,null,57419,null,null,"rs3790268-?","rs3790268",0,3790268,"intron",0,"NR",3e-07,6.52287874528033,null,"NR","NR","Affymetrix [338,079]","N"]
["V5 (down-regulated)","08/04/2009",19597492,"Benjamin EJ","07/13/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19597492?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.","Atrial fibrillation","3,413 cases, 37,105 referents","2,145 cases, 4,073 controls","1p36.22",1,11852516,"MTHFR, NPPA","- ",null,null,4524,null,null,"rs17375901-T","rs17375901",0,17375901,"intron",0,0.053,6e-07,6.22184874961635,null,1.26,null,"Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","08/07/2009",19584346,"Vasan RS","07/08/2009","JAMA","http://www.ncbi.nlm.nih.gov/pubmed/19584346?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.","Cardiac structure and function","12,612 European ancestry individuals","4,094 European ancestry individuals","16q23.1",16,78258810,"WWOX","- ",null,null,51741,null,null,"rs2059238-A","rs2059238",0,2059238,"intron",0,0.22,3e-06,5.52287874528033,"(LV wall thickness)",0.02,"[0.01-0.03] cm decrease","Affymetrix & Illumina [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","07/24/2009",19581569,"Treutlein J","07/01/2009","Arch Gen Psychiatry","http://www.ncbi.nlm.nih.gov/pubmed/19581569","Genome-wide association study of alcohol dependence.","Alcohol dependence","476 European ancestry cases, 1,358 European ancestry controls","1,024 European ancestry cases, 996 European ancestry controls","6q25.1",6,152157881,"ESR1","- ",null,null,2099,null,null,"rs6902771-C","rs6902771",0,6902771,"intron",0,0.51,8e-06,5.09691001300805,null,1.24,"[1.13-1.36] ","Illumina [524,396]","N"]
["V5 (down-regulated)","07/01/2009",19553259,"Cotsapas C","06/24/2009","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19553259","Common body mass index-associated variants confer risk of extreme obesity.","Obesity (extreme)","775 European ancestry cases, 3,197 European ancestry controls","NR","3p24.2",3,25560231,"RARB","- ",null,null,5915,null,null,"rs1435703-T","rs1435703",0,1435703,"intron",0,0.06,4e-06,5.39794000867203,null,1.66,"[1.34-2.06] ","Illumina [457,251]","N"]
["V5 (down-regulated)","05/19/2009",19430479,"Levy D","05/10/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19430479?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association study of blood pressure and hypertension.","Diastolic blood pressure","29,136 individuals","34,433 individuals","12q21.33",12,90008959,"ATP2B1","- ",null,null,490,null,null,"rs2681472-A","rs2681472",0,2681472,"intron",0,0.83,1e-09,8.99999999999999,null,0.5,"[0.34-0.66] mm Hg increase","Affymetrix & Illumina [2,533,153](imputed)","N"]
["V5 (down-regulated)","05/19/2009",19430479,"Levy D","05/10/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19430479?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association study of blood pressure and hypertension.","Hypertension","29,136 individuals","34,433 individuals","12q21.33",12,90008959,"ATP2B1","- ",null,null,490,null,null,"rs2681472-A","rs2681472",0,2681472,"intron",0,0.83,2e-11,10.698970004336,null,0.15,"[0.11-0.19] increase in log odds","Affymetrix & Illumina [2,533,153](imputed)","N"]
["V5 (down-regulated)","05/19/2009",19430479,"Levy D","05/10/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19430479?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association study of blood pressure and hypertension.","Systolic blood pressure","29,136 individuals","34,433 individuals","12q21.33",12,90013089,"ATP2B1","- ",null,null,490,null,null,"rs2681492-T","rs2681492",0,2681492,"intron",0,0.8,4e-11,10.397940008672,null,0.85,"[0.60-1.10] mm Hg increase","Affymetrix & Illumina [2,533,153](imputed)","N"]
["V5 (down-regulated)","05/19/2009",19430483,"Newton-Cheh C","05/10/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19430483?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association study identifies eight loci associated with blood pressure.","Systolic blood pressure","34,433 individuals"," (up-regulated) to 100,347 white individuals,  (up-regulated) to 12,889 Indian Asian individuals","1p36.22",1,11862778,"MTHFR, NPPA, CLCN6, NPPB, AGTRAP","- ",null,null,4524,null,null,"rs17367504-G","rs17367504",0,17367504,"intron",0,0.14,2e-13,12.698970004336,null,0.85,"[0.63-1.07] mm Hg decrease","Affymetrix & Illumina [2,497,993] (imputed)","N"]
["V5 (down-regulated)","05/07/2009",19401414,"Takeuchi F","04/29/2009","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/19401414","Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.","Type 2 diabetes","519 Japanese ancestry cases, 503 Japanese ancestry controls","5,629 Japanese ancestry cases, 7,370 Japanese ancestry controls","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-T","rs7903146",0,7903146,"intron",0,0.04,8e-12,11.096910013008,null,1.54,"[1.36-1.74] ","Illumina [482,625]","N"]
["V5 (down-regulated)","05/05/2009",19396169,"Cho YS","04/26/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19396169","A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.","Biomedical quantitative traits","8,842 Korean ancestry individuals","7,861 Korean ancestry individuals","12q21.33",12,90060586,"ATP2B1",null,490,347894,null,10.74,86.1,"rs17249754-A","rs17249754",0,17249754,null,1,0.37,3e-06,5.52287874528033,"(DBP)",0.63,"[0.37-0.89] mm Hg decrease","Affymetrix [2,156,535] (imputed)","N"]
["V5 (down-regulated)","05/05/2009",19396169,"Cho YS","04/26/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19396169","A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.","Biomedical quantitative traits","8,842 Korean ancestry individuals","7,861 Korean ancestry individuals","12q21.33",12,90060586,"ATP2B1",null,490,347894,null,10.74,86.1,"rs17249754-A","rs17249754",0,17249754,null,1,0.37,1e-07,7,"(SBP)",1.06,"[0.67-1.45] mm Hg decrease","Affymetrix [2,156,535] (imputed)","N"]
["V5 (down-regulated)","12/29/2009",20031578,"Pare G","04/01/2009","Circ Cardiovasc Genet","http://www.ncbi.nlm.nih.gov/pubmed/20031578","Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study.","Homocysteine levels","13,974 European ancestry females","840 European ancestry females","1p36.22",1,11856378,"MTHFR","- ",null,null,4524,null,null,"rs1801133-A","rs1801133",0,1801133,"missense",0,0.33,8e-35,34.096910013008,"(WGHS)",0.05,"[NR] unit increase in log(homocysteine)","Illumina [336,469]","N"]
["V5 (down-regulated)","03/31/2009",19305408,"Newton-Cheh C","03/22/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19305408?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Common variants at ten loci influence QT interval duration in the QTGEN Study.","QT interval","13,685 individuals","15,854 individuals","6q22.31",6,118993632,"c6orf204,SLC35F1, PLN, ASF1A","- ",null,null,387119,null,null,"rs11756438-A","rs11756438",0,11756438,"intron",0,0.47,5e-22,21.3010299956639,null,1.4,"[1.06-1.74] msec increase","Affymetrix and Illumina [ (up-regulated) to 2,543,686] (imputed)","N"]
["V5 (down-regulated)","03/31/2009",19305408,"Newton-Cheh C","03/22/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19305408?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Common variants at ten loci influence QT interval duration in the QTGEN Study.","QT interval","13,685 individuals","15,854 individuals","7q36.1",7,150637863,"KCNH2",null,26,3757,null,79.48,4.18,"rs4725982-T","rs4725982",0,4725982,null,1,0.22,5e-16,15.3010299956639,null,1.58,"[1.23-1.92] msec increase","Affymetrix and Illumina [ (up-regulated) to 2,543,686] (imputed)","N"]
["V5 (down-regulated)","03/31/2009",19305408,"Newton-Cheh C","03/22/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19305408?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Common variants at ten loci influence QT interval duration in the QTGEN Study.","QT interval","13,685 individuals","15,854 individuals","7q36.1",7,150622162,"KCNH2",null,26,3757,null,63.78,19.88,"rs2968864-C","rs2968864",0,2968864,null,1,0.25,8e-16,15.096910013008,null,1.4,"[1.06-1.74] msec decrease","Affymetrix and Illumina [ (up-regulated) to 2,543,686] (imputed)","N"]
["V5 (down-regulated)","04/02/2009",19305409,"Pfeufer A","03/22/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19305409?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Common variants at ten loci modulate the QT interval duration in the QTSCD Study.","QT interval","15,842 individuals"," (up-regulated) to 13,602 individuals","7q36.1",7,150623137,"KCNH2",null,26,3757,null,64.76,18.91,"rs2968863-T","rs2968863",0,2968863,null,1,0.29,2e-15,14.698970004336,null,1.35,"[0.90-1.80] ms decrease","Affymetrix and Illumina [unsure] (imputed)","N"]
["V5 (down-regulated)","03/30/2009",19300499,"Takeuchi F","03/20/2009","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/19300499?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.","Warfarin maintenance dose","1,053 individuals","588 individuals","10q23.33",10,96702047,"CYP2C9","- ",null,null,1559,null,null,"rs1799853-?","rs1799853",0,1799853,"missense",0,0.11,1e-31,31,null,0.54,"[0.45-0.63] mg/week decrease","Illumina [325,997]","N"]
["V5 (down-regulated)","03/30/2009",19300499,"Takeuchi F","03/20/2009","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/19300499?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.","Warfarin maintenance dose","1,053 individuals","588 individuals","10q23.33",10,96741053,"CYP2C9","- ",null,null,1559,null,null,"rs1057910-?","rs1057910",0,1057910,"missense",0,0.07,3e-79,78.5228787452803,null,1.11,"[1.00-1.22] mg/week decrease","Illumina [325,997]","N"]
["V5 (down-regulated)","02/28/2009",19219042,"Zheng W","02/15/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19219042","Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1.","Breast cancer","1,505 Chinese ancestry cases, 1,522 Chinese ancestry controls","1,554 Chinese ancestry cases, 1,576 Chinese ancestry controls","6q25.1",6,151948366,"ESR1, C6orf97",null,80129,2099,null,6.04,63.27,"rs2046210-A","rs2046210",0,2046210,null,1,0.37,2e-15,14.698970004336,null,1.29,"[1.21-1.37] ","Affymetrix [ (up-regulated) to 607,728]","N"]
["V5 (down-regulated)","03/01/2009",19198610,"Gudbjartsson DF","02/08/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19198610","Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.","Eosinophil counts","9,392 European ancestry individuals","12,118 European ancestry individuals, 5,212 East Asian ancestry individuals","3q21.3",3,128260550,"GATA2",null,100129727,23434,null,3.08,30.29,"rs4857855-T","rs4857855",0,4857855,null,1,0.82,9e-17,16.0457574905606,"(European)",9.4,"[7.2-11.6] % standard unit increase","Illumina [312,179]","N"]
["V5 (down-regulated)","03/01/2009",19198609,"Kathiresan S","02/08/2009","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19198609?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.","Myocardial infarction (early onset)","2,967 cases, 3,075 controls","9,746 cases, 9,746 controls","10q11.21",10,44775824,"CXCL12",null,100506835,6387,null,384.94,89.78,"rs1746048-C","rs1746048",0,1746048,null,1,0.84,7e-09,8.15490195998574,null,1.17,"[1.11-1.24] ","Affymetrix [~2.5 million] (imputed)","N"]
["V5 (down-regulated)","06/22/2009",19096518,"Pare G","12/19/2008","PLoS Genet","http://www.ncbi.nlm.nih.gov/pubmed/19096518","Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.","Glycated hemoglobin levels","14,618 European ancestry women","455 European ancestry men and women","10q22.1",10,71099913,"HK1","- ",null,null,3098,null,null,"rs7072268-A","rs7072268",0,7072268,"intron",0,0.5,2e-25,24.698970004336,null,0.05,"[NR] % increase","Illumina [337,343]","N"]
["V5 (down-regulated)","01/14/2009",19084217,"Benyamin B","12/17/2008","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/19084217?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.","Iron status biomarkers","459 twin pairs","NR","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-?","rs1800562",0,1800562,"missense",0,"NR",1e-10,10,"(serum transferrin)",0.68,"[0.48-0.88] s.d. decrease","Illumina [315,887]","N"]
["V5 (down-regulated)","01/14/2009",19084217,"Benyamin B","12/17/2008","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/19084217?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.","Iron status biomarkers","459 twin pairs","NR","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-?","rs1800562",0,1800562,"missense",0,"NR",4e-15,14.397940008672,"(transferrin saturation)","NR","NR","Illumina [315,887]","N"]
["V5 (down-regulated)","01/14/2009",19084217,"Benyamin B","12/17/2008","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/19084217?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.","Iron status biomarkers","459 twin pairs","NR","6p22.2",6,26093141,"HFE","- ",null,null,3077,null,null,"rs1800562-?","rs1800562",0,1800562,"missense",0,"NR",4e-11,10.397940008672,"(serum iron)",0.66,"[0.46-0.86] s.d. increase","Illumina [315,887]","N"]
["V5 (down-regulated)","01/16/2009",19079262,"Styrkarsdottir U","12/14/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19079262?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","New sequence variants associated with bone mineral density.","Bone mineral density (hip)","6,865 individuals","8,510 individuals","6q25.1",6,151933175,"ESR1","- ",null,null,80129,null,null,"rs1038304-G","rs1038304",0,1038304,"intron",0,0.47,4e-10,9.39794000867203,null,0.08,"[0.06-0.11] s.d. decrease","Illumina [305,051]","N"]
["V5 (down-regulated)","01/16/2009",19079262,"Styrkarsdottir U","12/14/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/19079262?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","New sequence variants associated with bone mineral density.","Bone mineral density (spine)","6,865 individuals","8,510 individuals","6q25.1",6,151936677,"C6orf97, ESR1","- ",null,null,80129,null,null,"rs6929137-A","rs6929137",0,6929137,"missense",0,0.3,2e-10,9.69897000433601,null,0.1,"[0.07-0.13] s.d. decrease","Illumina [305,051]","N"]
["V5 (down-regulated)","05/07/2009",18821565,"Lasky-Su J","12/05/2008","Am J Med Genet B Neuropsychiatr Genet","http://www.ncbi.nlm.nih.gov/pubmed/18821565?ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.","Attention deficit hyperactivity disorder","909 trios","NR","4q13.3",4,75224590,"EREG",null,255324,2069,null,42.07,6.27,"rs1350666-?","rs1350666",0,1350666,null,1,"NR",8e-06,5.09691001300805,"(binary)","NR","NR","Perlegen [429,981]","N"]
["V5 (down-regulated)","01/15/2009",19056611,"Timpson NJ","12/03/2008","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/19056611?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.","Type 2 diabetes","1,924 cases, 2,938 controls","3,757 cases, 5,346 controls","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-?","rs7903146",0,7903146,"intron",0,"NR",9e-30,29.0457574905606,"(non-obese)",1.49,"[1.39-1.59] ","Affymetrix [393,453]","N"]
["V5 (down-regulated)","01/15/2009",19056611,"Timpson NJ","12/03/2008","Diabetes","http://www.ncbi.nlm.nih.gov/pubmed/19056611?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.","Type 2 diabetes","1,924 cases, 2,938 controls","3,757 cases, 5,346 controls","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-?","rs7903146",0,7903146,"intron",0,"NR",6e-16,15.2218487496163,"(obese)",1.31,"[1.23-1.40] ","Affymetrix [393,453]","N"]
["V5 (down-regulated)","01/16/2009",19010793,"Baranzini SE","11/14/2008","Hum Mol Genet","http://www.ncbi.nlm.nih.gov/pubmed/19010793?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum","Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.","Normalized brain volume","753 cases,883 controls","NR","6q21",6,108916573,"FOXO3","- ",null,null,2309,null,null,"rs9480865-?","rs9480865",0,9480865,"intron",0,0.16,7e-06,5.15490195998574,null,"NR","NR","Illumina[551,642]","N"]
["V5 (down-regulated)","12/01/2008",18940312,"Yuan X","10/10/2008","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/18940312","Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.","Liver enzyme levels","7,751 European ancestry individuals","4,704 European ancestry and Asian Indian individuals","22q13.31",22,44332570,"PNPLA3, SAMM50","- ",null,null,80339,null,null,"rs2281135-T","rs2281135",0,2281135,"intron",0,0.18,8e-16,15.096910013008,"(ALT)",0.06,"[0.046-0.074] U/L increase","Affymetrix and Illumina[ (up-regulated) to 496,032]","N"]
["V5 (down-regulated)","11/25/2008",18535201,"Cooper GM","06/05/2008","Blood","http://www.ncbi.nlm.nih.gov/pubmed/18535201?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose.","Warfarin maintenance dose","181 individuals","374 individuals","10q23.33",10,96707202,"CYP2C9","- ",null,null,1559,null,null,"rs4086116-?","rs4086116",0,4086116,"intron",0,"NR",6e-12,11.2218487496163,null,"NR","NR","Illumina[538,629]","N"]
["V5 (down-regulated)","11/25/2008",18445777,"Styrkarsdottir U","04/29/2008","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/18445777?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Multiple genetic loci for bone mineral density and fractures.","Bone mineral density (hip)","5,861 individuals","7,925 individuals","6q25.1",6,151933175,"ESR1","- ",null,null,80129,null,null,"rs1038304-G","rs1038304",0,1038304,"intron",0,0.47,5e-09,8.30102999566398,null,0.08,"[0.06-0.11] s.d. decrease","Illumina[301,019]","N"]
["V5 (down-regulated)","11/25/2008",18445777,"Styrkarsdottir U","04/29/2008","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/18445777?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Multiple genetic loci for bone mineral density and fractures.","Bone mineral density (hip)","5,861 individuals","7,925 individuals","6q25.1",6,151901409,"ESR1, C6orf97","- ",null,null,80129,null,null,"rs4870044-T","rs4870044",0,4870044,"intron",0,0.28,2e-07,6.69897000433601,null,0.08,"[0.05-0.11] s.d. decrease","Illumina[301,019]","N"]
["V5 (down-regulated)","11/25/2008",18445777,"Styrkarsdottir U","04/29/2008","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/18445777?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Multiple genetic loci for bone mineral density and fractures.","Bone mineral density (spine)","5,861 individuals","7,925 individuals","6q25.1",6,151901409,"ESR1","- ",null,null,80129,null,null,"rs4870044-T","rs4870044",0,4870044,"intron",0,0.28,2e-11,10.698970004336,null,0.11,"[0.08-0.14] s.d. decrease","Illumina[301,019]","N"]
["V5 (down-regulated)","11/25/2008",18445777,"Styrkarsdottir U","04/29/2008","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/18445777?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Multiple genetic loci for bone mineral density and fractures.","Bone mineral density (spine)","5,861 individuals","7,925 individuals","6q25.1",6,151933175,"ESR1, C6orf97","- ",null,null,80129,null,null,"rs1038304-G","rs1038304",0,1038304,"intron",0,0.47,4e-11,10.397940008672,null,0.1,"[0.07-0.13] s.d. decrease","Illumina[301,019]","N"]
["V5 (down-regulated)","11/25/2008",18445777,"Styrkarsdottir U","04/29/2008","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/18445777?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Multiple genetic loci for bone mineral density and fractures.","Bone mineral density (spine)","5,861 individuals","7,925 individuals","6q25.1",6,152068364,"ESR1, C6orf97","- ",null,null,2099,null,null,"rs1999805-C","rs1999805",0,1999805,"intron",0,0.44,2e-08,7.69897000433601,null,0.09,"[0.06-0.12] s.d. decrease","Illumina[301,019]","N"]
["V5 (down-regulated)","11/25/2008",18391951,"Gudbjartsson DF","04/06/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18391951?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Many sequence variants affecting diversity of adult human height.","Height","30,968 individuals","8,541 individuals","17q23.2",17,59497277,"BCAS3, NACA2, TBX2, TBX4",null,6909,9496,null,10.45,36.53,"rs757608-T","rs757608",0,757608,null,1,0.35,6e-08,7.22184874961635,null,4.4,"[2.83-5.97] % s.d. taller","Illumina and Affymetrix[ (up-regulated) to 304,226]","N"]
["V5 (down-regulated)","11/25/2008",18391951,"Gudbjartsson DF","04/06/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18391951?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Many sequence variants affecting diversity of adult human height.","Height","30,968 individuals","8,541 individuals","6p22.3",6,17699322,"N (up-regulated)153, CAP2, KIF13A","- ",null,null,9972,null,null,"rs12199222-T","rs12199222",0,12199222,"intron",0,0.33,7e-07,6.15490195998574,null,4.4,"[2.64-6.16] % s.d. taller","Illumina and Affymetrix[ (up-regulated) to 304,226]","N"]
["V5 (down-regulated)","11/25/2008",18391951,"Gudbjartsson DF","04/06/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18391951?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Many sequence variants affecting diversity of adult human height.","Height","30,968 individuals","8,541 individuals","6p24.3",6,7720059,"BMP6",null,134756,654,null,98.94,6.95,"rs12198986-A","rs12198986",0,12198986,null,1,0.5,2e-11,10.698970004336,null,6.8,"[4.84-8.76] % s.d. taller","Illumina and Affymetrix[ (up-regulated) to 304,226]","N"]
["V5 (down-regulated)","11/25/2008",18391951,"Gudbjartsson DF","04/06/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18391951?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Many sequence variants affecting diversity of adult human height.","Height","30,968 individuals","8,541 individuals","12q22",12,93976954,"SOCS2, MRPL42, CRADD, UBE2N",null,8835,8738,null,6.43,94.2,"rs3825199-C","rs3825199",0,3825199,null,1,0.24,2e-07,6.69897000433601,null,6.2,"[3.85-8.55] % s.d. taller","Illumina and Affymetrix[ (up-regulated) to 304,226]","N"]
["V5 (down-regulated)","11/25/2008",18372903,"Zeggini E","03/30/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18372903?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.","Type 2 diabetes","4,549 cases,5,579 controls","24,194 cases,55,598 controls","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-T","rs7903146",0,7903146,"intron",0,"NR",3e-23,22.5228787452803,null,1.37,"[1.28-1.47] ","Affymetrix and Illumina[2,202,892](imputed)","N"]
["V5 (down-regulated)","11/25/2008",18264096,"Thomas G","02/10/2008","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/18264096?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Multiple loci identified in a genome-wide association study of prostate cancer.","Prostate cancer","1,172 cases,1,157 controls","3,941 cases,3,964 controls","10q26.13",10,126696872,"CTBP2","- ",null,null,1488,null,null,"rs4962416-C","rs4962416",0,4962416,"intron",0,0.27,2e-07,6.69897000433601,null,1.17,"[1.05-1.30] ","Illumina[527,869]","N"]
["V5 (down-regulated)","11/25/2008",17903301,"Vasan RS","09/19/2007","BMC Med Genet","http://www.ncbi.nlm.nih.gov/pubmed/17903301?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study.","Endothelial function traits","1,238 individuals(Framingham)","NR","10q24.33",10,105647095,"OBFC1","- ",null,null,79991,null,null,"rs3814219-?","rs3814219",0,3814219,"intron",0,"NR",9e-07,6.04575749056067,"(BABF)","NR","NR","Affymetrix[70,897]","N"]
["V5 (down-regulated)","11/25/2008",17634449,"Samani NJ","07/18/2007","N Engl J Med","http://www.ncbi.nlm.nih.gov/pubmed/17634449?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genomewide association analysis of coronary artery disease.","Coronary heart disease","1,926 cases,2,938 controls","875 cases,1,644 controls","10q11.21",10,44753867,"CXCL12",null,100506835,6387,null,362.99,111.74,"rs501120-T","rs501120",0,501120,null,1,0.87,9e-08,7.04575749056067,null,1.33,"[1.20-1.48] ","Affymetrix [377,857]","N"]
["V5 (down-regulated)","11/25/2008",17668382,"Salonen JT","06/26/2007","Am J Hum Genet","http://www.ncbi.nlm.nih.gov/pubmed/17668382?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium.","Type 2 diabetes","500 cases,497 controls","2,573 cases,2,776 controls","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-A","rs7903146",0,7903146,"intron",0,"NR",5e-08,7.30102999566398,null,1.71,"[1.41-2.08] ","Illumina  [315,917]","N"]
["V5 (down-regulated)","11/25/2008",17554300,"WTCCC","06/07/2007","Nature","http://www.ncbi.nlm.nih.gov/pubmed/17554300?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.","Type 2 diabetes","1,924 cases,2,938 controls","(see Zeggini 2007)","10q25.2",10,114756041,"TCF7L2","- ",null,null,6934,null,null,"rs4506565-T","rs4506565",0,4506565,"intron",0,0.32,5e-12,11.3010299956639,null,1.36,"[1.20-1.54] ","Affymetrix[469,557]","N"]
["V5 (down-regulated)","11/25/2008",17463246,"Saxena R","04/26/2007","Science","http://www.ncbi.nlm.nih.gov/pubmed/17463246?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.","Type 2 diabetes","1,464 cases,1,467 controls","5,065 cases,5,785 controls (also includes meta-analysis from DGI+FUSION+WTCCC)","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-T","rs7903146",0,7903146,"intron",0,0.26,2e-31,30.698970004336,null,1.38,"[1.31-1.46] ","Affymetrix[386,731]","N"]
["V5 (down-regulated)","11/25/2008",17463248,"Scott LJ","04/26/2007","Science","http://www.ncbi.nlm.nih.gov/pubmed/17463248?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.","Type 2 diabetes","1,161 cases,1,174 controls","1,215 cases,1,258 controls (also includes meta-analysis from DGI+FUSION+WTCCC)","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-T","rs7903146",0,7903146,"intron",0,0.18,1e-08,8,null,1.34,"[1.21-1.49] ","Illumina[315,635]","N"]
["V5 (down-regulated)","11/25/2008",17460697,"Steinthorsdottir V","04/26/2007","Nat Genet","http://www.ncbi.nlm.nih.gov/pubmed/17460697?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.","Type 2 diabetes","1,399 EA cases,5,275 EA controls","2,437 EA cases,7,287 EA controls","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-?","rs7903146",0,7903146,"intron",0,0.3,2e-10,9.69897000433601,null,1.38,"[NR] ","Illumina[313,179 SNPs; 339,846 2-SNP haplotypes]","N"]
["V5 (down-regulated)","11/25/2008",17463249,"Zeggini E","04/26/2007","Science","http://www.ncbi.nlm.nih.gov/pubmed/17463249?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.","Type 2 diabetes","1,924 cases,2,938 controls","3,757 cases,5,346 controls (also includes meta-analysis from DGI+FUSION+WTCCC)","10q25.2",10,114754088,"TCF7L2","- ",null,null,6934,null,null,"rs7901695-C","rs7901695",0,7901695,"intron",0,"NR",1e-48,47.9999999999999,"(DGI+FUSION+WTCCC)",1.37,"[1.31-1.43] ","Affymetrix[393,453]","N"]
["V5 (down-regulated)","11/25/2008",17293876,"Sladek R","02/11/2007","Nature","http://www.ncbi.nlm.nih.gov/pubmed/17293876?ordinalpos=24&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum","A genome-wide association study identifies novel risk loci for type 2 diabetes.","Type 2 diabetes","661 cases,614 controls","2,617 cases,2,894 controls","10q25.2",10,114758349,"TCF7L2","- ",null,null,6934,null,null,"rs7903146-T","rs7903146",0,7903146,"intron",0,0.3,2e-34,33.698970004336,null,1.65,"[1.28, 2.02] ","Illumina [392,935]","N"]