# Electronic Supplementary Material (ESI) for RSC Advances.
# This journal is © The Royal Society of Chemistry 2015

####################################################################### 
# 
# This file contains crystal structure data downloaded from the 
# Cambridge Structural Database (CSD) hosted by the Cambridge 
# Crystallographic Data Centre (CCDC).
# 
# Full information about CCDC data access policies and citation 
# guidelines are available at http://www.ccdc.cam.ac.uk/access/V1 
# 
# Audit and citation data items may have been added by the CCDC. 
# Please retain this information to preserve the provenance of 
# this file and to allow appropriate attribution of the data. 
# 
#######################################################################

data_1
_database_code_depnum_ccdc_archive 'CCDC 1032275'
_audit_update_record             
;
2014-11-02 deposited with the CCDC.
2015-08-10 downloaded from the CCDC.
;

_audit_creation_method           SHELXL-97
_chemical_name_systematic        
; 
 ? 
;
_chemical_name_common            ?
_chemical_melting_point          ?
_chemical_formula_moiety         ?
_chemical_formula_sum            'C24 H16 N3 O4'
_chemical_formula_weight         410.40

loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
N N 0.0061 0.0033 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'

_symmetry_cell_setting           Monoclinic
_symmetry_space_group_name_H-M   P2(1)/c

loop_
_symmetry_equiv_pos_as_xyz
'x, y, z'
'-x, y+1/2, -z+1/2'
'-x, -y, -z'
'x, -y-1/2, z-1/2'

_cell_length_a                   9.1046(11)
_cell_length_b                   27.117(3)
_cell_length_c                   8.5164(11)
_cell_angle_alpha                90.00
_cell_angle_beta                 102.813(2)
_cell_angle_gamma                90.00
_cell_volume                     2050.3(4)
_cell_formula_units_Z            4
_cell_measurement_temperature    298(2)
_cell_measurement_reflns_used    2005
_cell_measurement_theta_min      2.41
_cell_measurement_theta_max      22.30

_exptl_crystal_description       block
_exptl_crystal_colour            brown
_exptl_crystal_size_max          0.28
_exptl_crystal_size_mid          0.26
_exptl_crystal_size_min          0.22
_exptl_crystal_density_meas      ?
_exptl_crystal_density_diffrn    1.330
_exptl_crystal_density_method    'not measured'
_exptl_crystal_F_000             852
_exptl_absorpt_coefficient_mu    0.093
_exptl_absorpt_correction_type   ?
_exptl_absorpt_correction_T_min  0.9745
_exptl_absorpt_correction_T_max  0.9799
_exptl_absorpt_process_details   ?

_exptl_special_details           
; 
 ? 
;

_diffrn_ambient_temperature      298(2)
_diffrn_radiation_wavelength     0.71073
_diffrn_radiation_type           MoK\a
_diffrn_radiation_source         'fine-focus sealed tube'
_diffrn_radiation_monochromator  graphite
_diffrn_measurement_device_type  ?
_diffrn_measurement_method       ?
_diffrn_detector_area_resol_mean ?
_diffrn_standards_number         ?
_diffrn_standards_interval_count ?
_diffrn_standards_interval_time  ?
_diffrn_standards_decay_%        ?
_diffrn_reflns_number            11638
_diffrn_reflns_av_R_equivalents  0.0361
_diffrn_reflns_av_sigmaI/netI    0.0412
_diffrn_reflns_limit_h_min       -10
_diffrn_reflns_limit_h_max       10
_diffrn_reflns_limit_k_min       -25
_diffrn_reflns_limit_k_max       32
_diffrn_reflns_limit_l_min       -10
_diffrn_reflns_limit_l_max       10
_diffrn_reflns_theta_min         1.50
_diffrn_reflns_theta_max         25.15
_reflns_number_total             3664
_reflns_number_gt                2296
_reflns_threshold_expression     >2sigma(I)

_computing_data_collection       'Bruker SMART'
_computing_cell_refinement       'Bruker SMART'
_computing_data_reduction        'Bruker SAINT'
_computing_structure_solution    'SHELXS-97 (Sheldrick, 1990)'
_computing_structure_refinement  'SHELXL-97 (Sheldrick, 1997)'
_computing_molecular_graphics    'Bruker SHELXTL'
_computing_publication_material  'Bruker SHELXTL'

_refine_special_details          
; 
 Refinement of F² against ALL reflections.  The weighted R-factor wR and 
 goodness of fit S are based on F², conventional R-factors R are based 
 on F, with F set to zero for negative F². The threshold expression of 
 F² > 2sigma(F²) is used only for calculating R-factors(gt) etc. and is 
 not relevant to the choice of reflections for refinement.  R-factors based 
 on F² are statistically about twice as large as those based on F, and R- 
 factors based on ALL data will be even larger. 
;

_refine_ls_structure_factor_coef Fsqd
_refine_ls_matrix_type           full
_refine_ls_weighting_scheme      calc
_refine_ls_weighting_details     
'calc w=1/[σ²(Fo²)+(0.0755P)²+0.2481P] where P=(Fo²+2Fc²)/3'
_atom_sites_solution_primary     direct
_atom_sites_solution_secondary   difmap
_atom_sites_solution_hydrogens   geom
_refine_ls_hydrogen_treatment    mixed
_refine_ls_extinction_method     none
_refine_ls_extinction_coef       ?
_refine_ls_number_reflns         3664
_refine_ls_number_parameters     281
_refine_ls_number_restraints     0
_refine_ls_R_factor_all          0.0900
_refine_ls_R_factor_gt           0.0516
_refine_ls_wR_factor_ref         0.1630
_refine_ls_wR_factor_gt          0.1324
_refine_ls_goodness_of_fit_ref   1.080
_refine_ls_restrained_S_all      1.080
_refine_ls_shift/su_max          0.013
_refine_ls_shift/su_mean         0.003

loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_symmetry_multiplicity
_atom_site_calc_flag
_atom_site_refinement_flags
_atom_site_disorder_assembly
_atom_site_disorder_group
N1 N -0.3997(4) 0.56492(12) 0.6526(4) 0.1190(13) Uani 1 1 d . . .
N2 N -0.1742(3) 0.70013(9) 0.6243(3) 0.0681(7) Uani 1 1 d . . .
N3 N 0.8534(2) 0.69077(7) 0.0530(2) 0.0481(5) Uani 1 1 d . . .
O1 O 0.09757(18) 0.55356(6) 0.2662(2) 0.0493(5) Uani 1 1 d . . .
O2 O 0.9581(2) 0.62456(7) -0.0520(2) 0.0626(6) Uani 1 1 d . . .
O3 O 1.0706(2) 0.74774(7) -0.0270(3) 0.0785(7) Uani 1 1 d . . .
O4 O 1.16907(19) 0.68186(6) -0.1242(2) 0.0558(5) Uani 1 1 d . . .
C1 C -0.2504(3) 0.50865(9) 0.3642(3) 0.0540(7) Uani 1 1 d . . .
H1 H -0.3253 0.5178 0.4171 0.065 Uiso 1 1 calc R . .
C2 C -0.2590(3) 0.46355(10) 0.2898(4) 0.0634(8) Uani 1 1 d . . .
H2 H -0.3394 0.4427 0.2926 0.076 Uiso 1 1 calc R . .
C3 C -0.1488(3) 0.44889(9) 0.2106(3) 0.0575(7) Uani 1 1 d . . .
H3 H -0.1544 0.4180 0.1623 0.069 Uiso 1 1 calc R . .
C4 C -0.0326(3) 0.47963(9) 0.2036(3) 0.0524(7) Uani 1 1 d . . .
H4 H 0.0407 0.4702 0.1489 0.063 Uiso 1 1 calc R . .
C5 C -0.0246(3) 0.52519(9) 0.2790(3) 0.0436(6) Uani 1 1 d . . .
C6 C -0.1323(3) 0.54114(8) 0.3625(3) 0.0416(6) Uani 1 1 d . . .
C7 C -0.1141(3) 0.59005(8) 0.4356(3) 0.0433(6) Uani 1 1 d . . .
C8 C -0.2045(3) 0.60972(9) 0.5317(3) 0.0466(6) Uani 1 1 d . . .
C9 C -0.1861(3) 0.65978(11) 0.5836(3) 0.0530(7) Uani 1 1 d . . .
C10 C -0.3131(3) 0.58413(11) 0.5948(4) 0.0664(8) Uani 1 1 d . . .
C11 C 0.0081(3) 0.61855(9) 0.4036(3) 0.0450(6) Uani 1 1 d . . .
H11 H 0.0186 0.6511 0.4387 0.054 Uiso 1 1 calc R . .
C12 C 0.1082(3) 0.60004(9) 0.3249(3) 0.0433(6) Uani 1 1 d . . .
C13 C 0.2395(3) 0.62587(9) 0.2965(3) 0.0503(7) Uani 1 1 d . . .
H13 H 0.2546 0.6583 0.3316 0.060 Uiso 1 1 calc R . .
C14 C 0.3397(3) 0.60564(10) 0.2229(3) 0.0504(7) Uani 1 1 d . . .
H14 H 0.3224 0.5728 0.1924 0.061 Uiso 1 1 calc R . .
C15 C 0.4718(3) 0.62795(9) 0.1844(3) 0.0448(6) Uani 1 1 d . . .
C16 C 0.5256(3) 0.67487(9) 0.2339(3) 0.0525(7) Uani 1 1 d . . .
H16 H 0.4759 0.6935 0.2980 0.063 Uiso 1 1 calc R . .
C17 C 0.6503(3) 0.69430(9) 0.1904(3) 0.0505(7) Uani 1 1 d . . .
H17 H 0.6832 0.7258 0.2250 0.061 Uiso 1 1 calc R . .
C18 C 0.7278(3) 0.66758(9) 0.0956(3) 0.0430(6) Uani 1 1 d . . .
C19 C 0.6793(3) 0.62051(9) 0.0483(3) 0.0514(7) Uani 1 1 d . . .
H19 H 0.7315 0.6016 -0.0126 0.062 Uiso 1 1 calc R . .
C20 C 0.5529(3) 0.60156(9) 0.0918(3) 0.0530(7) Uani 1 1 d . . .
H20 H 0.5209 0.5700 0.0578 0.064 Uiso 1 1 calc R . .
C21 C 0.9546(3) 0.66790(10) -0.0182(3) 0.0468(6) Uani 1 1 d . . .
C22 C 1.0707(3) 0.70432(10) -0.0566(3) 0.0496(7) Uani 1 1 d . . .
C23 C 1.2845(3) 0.71279(10) -0.1679(3) 0.0597(8) Uani 1 1 d . . .
H23A H 1.3529 0.7249 -0.0717 0.072 Uiso 1 1 calc R . .
H23B H 1.2385 0.7409 -0.2305 0.072 Uiso 1 1 calc R . .
C24 C 1.3680(3) 0.68233(11) -0.2643(4) 0.0702(9) Uani 1 1 d . . .
H24A H 1.4150 0.6551 -0.2005 0.105 Uiso 1 1 calc R . .
H24B H 1.4437 0.7021 -0.2963 0.105 Uiso 1 1 calc R . .
H24C H 1.2991 0.6701 -0.3583 0.105 Uiso 1 1 calc R . .


_geom_special_details            
; 
 All esds (except the esd in the dihedral angle between two l.s. planes) 
 are estimated using the full covariance matrix.  The cell esds are taken 
 into account individually in the estimation of esds in distances, angles 
 and torsion angles; correlations between esds in cell parameters are only 
 used when they are defined by crystal symmetry.  An approximate (isotropic) 
 treatment of cell esds is used for estimating esds involving l.s. planes. 
;

loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
_geom_bond_site_symmetry_2
_geom_bond_publ_flag
N1 C10 1.143(4) . ?
N2 C9 1.146(3) . ?
N3 C21 1.360(3) . ?
N3 C18 1.421(3) . ?
O1 C12 1.351(3) . ?
O1 C5 1.376(3) . ?
O2 C21 1.212(3) . ?
O3 C22 1.204(3) . ?
O4 C22 1.316(3) . ?
O4 C23 1.456(3) . ?
C1 C2 1.372(4) . ?
C1 C6 1.393(3) . ?
C1 H1 0.9300 . ?
C2 C3 1.385(3) . ?
C2 H2 0.9300 . ?
C3 C4 1.359(3) . ?
C3 H3 0.9300 . ?
C4 C5 1.387(3) . ?
C4 H4 0.9300 . ?
C5 C6 1.401(3) . ?
C6 C7 1.459(3) . ?
C7 C8 1.389(3) . ?
C7 C11 1.429(3) . ?
C8 C10 1.409(4) . ?
C8 C9 1.426(4) . ?
C11 C12 1.343(3) . ?
C11 H11 0.9300 . ?
C12 C13 1.451(3) . ?
C13 C14 1.334(3) . ?
C13 H13 0.9300 . ?
C14 C15 1.447(3) . ?
C14 H14 0.9300 . ?
C15 C20 1.392(3) . ?
C15 C16 1.395(3) . ?
C16 C17 1.375(3) . ?
C16 H16 0.9300 . ?
C17 C18 1.388(3) . ?
C17 H17 0.9300 . ?
C18 C19 1.381(3) . ?
C19 C20 1.384(3) . ?
C19 H19 0.9300 . ?
C20 H20 0.9300 . ?
C21 C22 1.534(3) . ?
C23 C24 1.487(4) . ?
C23 H23A 0.9700 . ?
C23 H23B 0.9700 . ?
C24 H24A 0.9600 . ?
C24 H24B 0.9600 . ?
C24 H24C 0.9600 . ?

loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
_geom_angle_site_symmetry_1
_geom_angle_site_symmetry_3
_geom_angle_publ_flag
C21 N3 C18 125.1(2) . . ?
C12 O1 C5 119.01(18) . . ?
C22 O4 C23 116.4(2) . . ?
C2 C1 C6 121.6(2) . . ?
C2 C1 H1 119.2 . . ?
C6 C1 H1 119.2 . . ?
C1 C2 C3 120.5(3) . . ?
C1 C2 H2 119.8 . . ?
C3 C2 H2 119.8 . . ?
C4 C3 C2 120.0(2) . . ?
C4 C3 H3 120.0 . . ?
C2 C3 H3 120.0 . . ?
C3 C4 C5 119.2(2) . . ?
C3 C4 H4 120.4 . . ?
C5 C4 H4 120.4 . . ?
O1 C5 C4 114.9(2) . . ?
O1 C5 C6 122.4(2) . . ?
C4 C5 C6 122.6(2) . . ?
C1 C6 C5 116.0(2) . . ?
C1 C6 C7 125.8(2) . . ?
C5 C6 C7 118.1(2) . . ?
C8 C7 C11 119.5(2) . . ?
C8 C7 C6 125.1(2) . . ?
C11 C7 C6 115.5(2) . . ?
C7 C8 C10 126.4(2) . . ?
C7 C8 C9 120.3(2) . . ?
C10 C8 C9 113.2(2) . . ?
N2 C9 C8 178.7(3) . . ?
N1 C10 C8 176.5(3) . . ?
C12 C11 C7 122.4(2) . . ?
C12 C11 H11 118.8 . . ?
C7 C11 H11 118.8 . . ?
C11 C12 O1 122.2(2) . . ?
C11 C12 C13 125.3(2) . . ?
O1 C12 C13 112.5(2) . . ?
C14 C13 C12 123.6(2) . . ?
C14 C13 H13 118.2 . . ?
C12 C13 H13 118.2 . . ?
C13 C14 C15 128.6(2) . . ?
C13 C14 H14 115.7 . . ?
C15 C14 H14 115.7 . . ?
C20 C15 C16 116.5(2) . . ?
C20 C15 C14 119.1(2) . . ?
C16 C15 C14 124.5(2) . . ?
C17 C16 C15 121.6(2) . . ?
C17 C16 H16 119.2 . . ?
C15 C16 H16 119.2 . . ?
C16 C17 C18 120.9(2) . . ?
C16 C17 H17 119.6 . . ?
C18 C17 H17 119.6 . . ?
C19 C18 C17 118.8(2) . . ?
C19 C18 N3 123.9(2) . . ?
C17 C18 N3 117.3(2) . . ?
C18 C19 C20 119.7(2) . . ?
C18 C19 H19 120.1 . . ?
C20 C19 H19 120.1 . . ?
C19 C20 C15 122.6(2) . . ?
C19 C20 H20 118.7 . . ?
C15 C20 H20 118.7 . . ?
O2 C21 N3 127.2(2) . . ?
O2 C21 C22 121.2(2) . . ?
N3 C21 C22 111.6(2) . . ?
O3 C22 O4 125.2(2) . . ?
O3 C22 C21 123.5(2) . . ?
O4 C22 C21 111.3(2) . . ?
O4 C23 C24 107.9(2) . . ?
O4 C23 H23A 110.1 . . ?
C24 C23 H23A 110.1 . . ?
O4 C23 H23B 110.1 . . ?
C24 C23 H23B 110.1 . . ?
H23A C23 H23B 108.4 . . ?
C23 C24 H24A 109.5 . . ?
C23 C24 H24B 109.5 . . ?
H24A C24 H24B 109.5 . . ?
C23 C24 H24C 109.5 . . ?
H24A C24 H24C 109.5 . . ?
H24B C24 H24C 109.5 . . ?

loop_
_geom_torsion_atom_site_label_1
_geom_torsion_atom_site_label_2
_geom_torsion_atom_site_label_3
_geom_torsion_atom_site_label_4
_geom_torsion
_geom_torsion_site_symmetry_1
_geom_torsion_site_symmetry_2
_geom_torsion_site_symmetry_3
_geom_torsion_site_symmetry_4
_geom_torsion_publ_flag
C6 C1 C2 C3 0.3(4) . . . . ?
C1 C2 C3 C4 -1.2(4) . . . . ?
C2 C3 C4 C5 1.2(4) . . . . ?
C12 O1 C5 C4 174.8(2) . . . . ?
C12 O1 C5 C6 -5.5(3) . . . . ?
C3 C4 C5 O1 179.6(2) . . . . ?
C3 C4 C5 C6 -0.2(4) . . . . ?
C2 C1 C6 C5 0.7(4) . . . . ?
C2 C1 C6 C7 179.0(2) . . . . ?
O1 C5 C6 C1 179.5(2) . . . . ?
C4 C5 C6 C1 -0.7(4) . . . . ?
O1 C5 C6 C7 1.1(3) . . . . ?
C4 C5 C6 C7 -179.2(2) . . . . ?
C1 C6 C7 C8 6.7(4) . . . . ?
C5 C6 C7 C8 -175.1(2) . . . . ?
C1 C6 C7 C11 -173.8(2) . . . . ?
C5 C6 C7 C11 4.5(3) . . . . ?
C11 C7 C8 C10 -169.4(3) . . . . ?
C6 C7 C8 C10 10.1(4) . . . . ?
C11 C7 C8 C9 6.8(4) . . . . ?
C6 C7 C8 C9 -173.6(2) . . . . ?
C7 C8 C9 N2 128(13) . . . . ?
C10 C8 C9 N2 -55(13) . . . . ?
C7 C8 C10 N1 149(6) . . . . ?
C9 C8 C10 N1 -28(7) . . . . ?
C8 C7 C11 C12 173.4(2) . . . . ?
C6 C7 C11 C12 -6.1(3) . . . . ?
C7 C11 C12 O1 2.0(4) . . . . ?
C7 C11 C12 C13 -176.2(2) . . . . ?
C5 O1 C12 C11 4.0(3) . . . . ?
C5 O1 C12 C13 -177.6(2) . . . . ?
C11 C12 C13 C14 177.4(2) . . . . ?
O1 C12 C13 C14 -1.0(4) . . . . ?
C12 C13 C14 C15 178.2(2) . . . . ?
C13 C14 C15 C20 -173.4(3) . . . . ?
C13 C14 C15 C16 6.7(4) . . . . ?
C20 C15 C16 C17 1.4(4) . . . . ?
C14 C15 C16 C17 -178.7(2) . . . . ?
C15 C16 C17 C18 -0.3(4) . . . . ?
C16 C17 C18 C19 -1.4(4) . . . . ?
C16 C17 C18 N3 178.6(2) . . . . ?
C21 N3 C18 C19 -10.2(4) . . . . ?
C21 N3 C18 C17 169.8(2) . . . . ?
C17 C18 C19 C20 1.9(4) . . . . ?
N3 C18 C19 C20 -178.1(2) . . . . ?
C18 C19 C20 C15 -0.8(4) . . . . ?
C16 C15 C20 C19 -0.8(4) . . . . ?
C14 C15 C20 C19 179.3(2) . . . . ?
C18 N3 C21 O2 -2.6(4) . . . . ?
C18 N3 C21 C22 176.6(2) . . . . ?
C23 O4 C22 O3 -1.0(4) . . . . ?
C23 O4 C22 C21 179.4(2) . . . . ?
O2 C21 C22 O3 179.1(3) . . . . ?
N3 C21 C22 O3 -0.2(4) . . . . ?
O2 C21 C22 O4 -1.3(3) . . . . ?
N3 C21 C22 O4 179.4(2) . . . . ?
C22 O4 C23 C24 -171.2(2) . . . . ?

_diffrn_measured_fraction_theta_max 0.999
_diffrn_reflns_theta_full        25.15
_diffrn_measured_fraction_theta_full 0.999
_refine_diff_density_max         0.418
_refine_diff_density_min         -0.183
_refine_diff_density_rms         0.041
