# Electronic Supplementary Material (ESI) for ChemComm.
# This journal is © The Royal Society of Chemistry 2016

####################################################################### 
# 
# This file contains crystal structure data downloaded from the 
# Cambridge Structural Database (CSD) hosted by the Cambridge 
# Crystallographic Data Centre (CCDC).
# 
# Full information about CCDC data access policies and citation 
# guidelines are available at http://www.ccdc.cam.ac.uk/access/V1 
# 
# Audit and citation data items may have been added by the CCDC. 
# Please retain this information to preserve the provenance of 
# this file and to allow appropriate attribution of the data. 
# 
#######################################################################

data_dm_1
_database_code_depnum_ccdc_archive 'CCDC 1473112'
_audit_update_record             
;
2016-04-08 deposited with the CCDC.
2016-12-01 downloaded from the CCDC.
;

_audit_creation_method           SHELXL-2014
_chemical_name_systematic        
;
 ?
;
_chemical_name_common            ?
_chemical_melting_point          ?
_chemical_formula_moiety         ?
_chemical_formula_sum            'C18 H20 Br2 Cl2 Cu N4 O S'
_chemical_formula_weight         634.70

loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
N N 0.0061 0.0033 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
Br Br -0.2901 2.4595 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
Cl Cl 0.1484 0.1585 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
S S 0.1246 0.1234 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
Cu Cu 0.3201 1.2651 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'

_space_group_crystal_system      monoclinic
_space_group_IT_number           14
_space_group_name_H-M_alt        'P 21/c'
_space_group_name_Hall           '-P 2ybc'

_shelx_space_group_comment       
;
The symmetry employed for this shelxl refinement is uniquely defined
by the following loop, which should always be used as a source of
symmetry information in preference to the above space-group names.
They are only intended as comments.
;

loop_
_space_group_symop_operation_xyz
'x, y, z'
'x, -y+1/2, z+1/2'
'-x, -y, -z'
'-x, y-1/2, -z-1/2'

_cell_length_a                   14.2258(17)
_cell_length_b                   12.7624(18)
_cell_length_c                   13.8668(13)
_cell_angle_alpha                90
_cell_angle_beta                 117.138(14)
_cell_angle_gamma                90
_cell_volume                     2240.4(5)
_cell_formula_units_Z            4
_cell_measurement_temperature    149.9(2)
_cell_measurement_reflns_used    995
_cell_measurement_theta_min      3.5940
_cell_measurement_theta_max      25.3320

_exptl_crystal_description       Parallelepiped
_exptl_crystal_colour            Red
_exptl_crystal_density_meas      ?
_exptl_crystal_density_method    ?
_exptl_crystal_density_diffrn    1.882
_exptl_crystal_F_000             1252
_exptl_transmission_factor_min   ?
_exptl_transmission_factor_max   ?
_exptl_crystal_size_max          0.20
_exptl_crystal_size_mid          0.17
_exptl_crystal_size_min          0.02
_exptl_absorpt_coefficient_mu    4.892
_shelx_estimated_absorpt_T_min   0.441
_shelx_estimated_absorpt_T_max   0.909
_exptl_absorpt_correction_type   multi-scan
_exptl_absorpt_correction_T_min  0.70377
_exptl_absorpt_correction_T_max  1.00000
_exptl_absorpt_process_details   
;
crysalispro, agilent technologies,
version 1.171.37.31 (release 14-01-2014 crysalis171 .net)
(compiled jan 14 2014,18:38:05)
empirical absorption correction using spherical harmonics,
 implemented in scale3 abspack scaling algorithm.
;

_exptl_special_details           
;
 ?
;

_diffrn_ambient_temperature      149.9(2)
_diffrn_radiation_wavelength     0.71073
_diffrn_radiation_type           MoK\a
_diffrn_source                   'Enhance (Mo) X-ray Source'
_diffrn_measurement_device_type  'Xcalibur, Sapphire3'
_diffrn_measurement_method       'ω scans'
_diffrn_detector_area_resol_mean 16.1048
_diffrn_reflns_number            10637
_diffrn_reflns_av_unetI/netI     0.2470
_diffrn_reflns_av_R_equivalents  0.0978
_diffrn_reflns_limit_h_min       -18
_diffrn_reflns_limit_h_max       19
_diffrn_reflns_limit_k_min       -16
_diffrn_reflns_limit_k_max       16
_diffrn_reflns_limit_l_min       -19
_diffrn_reflns_limit_l_max       18
_diffrn_reflns_theta_min         2.940
_diffrn_reflns_theta_max         29.342
_diffrn_reflns_theta_full        25.242
_diffrn_measured_fraction_theta_max 0.844
_diffrn_measured_fraction_theta_full 0.999
_diffrn_reflns_Laue_measured_fraction_max 0.844
_diffrn_reflns_Laue_measured_fraction_full 0.999
_diffrn_reflns_point_group_measured_fraction_max 0.844
_diffrn_reflns_point_group_measured_fraction_full 0.999
_reflns_number_total             5182
_reflns_number_gt                2126
_reflns_threshold_expression     'I > 2σ(I)'
_reflns_Friedel_coverage         0.000
_reflns_Friedel_fraction_max     .
_reflns_Friedel_fraction_full    .

_reflns_special_details          
;
 Reflections were merged by SHELXL according to the crystal
 class for the calculation of statistics and refinement.
  
 _reflns_Friedel_fraction is defined as the number of unique
 Friedel pairs measured divided by the number that would be
 possible theoretically, ignoring centric projections and
 systematic absences.
;

_computing_data_collection       
;
'Sat Mar 22 04:50:10 2014'
;
_computing_cell_refinement       
;
'Sat Mar 22 04:50:10 2014'
;
_computing_data_reduction        
;
'Sat Mar 22 04:50:10 2014'
;
_computing_structure_solution    ?
_computing_structure_refinement  'SHELXL-2014 (Sheldrick, 2014)'
_computing_molecular_graphics    ?
_computing_publication_material  ?

_refine_special_details          
;
 ?
;
_refine_ls_structure_factor_coef Fsqd
_refine_ls_matrix_type           full
_refine_ls_weighting_scheme      calc
_refine_ls_weighting_details     
'w=1/[σ²(Fo²)+(0.0608P)²] where P=(Fo²+2Fc²)/3'
_atom_sites_solution_primary     ?
_atom_sites_solution_secondary   ?
_atom_sites_solution_hydrogens   geom
_refine_ls_hydrogen_treatment    constr
_refine_ls_extinction_method     none
_refine_ls_extinction_coef       .
_refine_ls_number_reflns         5182
_refine_ls_number_parameters     181
_refine_ls_number_restraints     12
_refine_ls_R_factor_all          0.2037
_refine_ls_R_factor_gt           0.0863
_refine_ls_wR_factor_ref         0.2413
_refine_ls_wR_factor_gt          0.1766
_refine_ls_goodness_of_fit_ref   1.017
_refine_ls_restrained_S_all      1.020
_refine_ls_shift/su_max          0.000
_refine_ls_shift/su_mean         0.000

loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_site_symmetry_order
_atom_site_calc_flag
_atom_site_refinement_flags_posn
_atom_site_refinement_flags_adp
_atom_site_refinement_flags_occupancy
_atom_site_disorder_assembly
_atom_site_disorder_group
Cu1 Cu 0.35503(11) 0.16763(13) 0.48450(10) 0.0251(4) Uani 1 1 d . . . . .
Br1 Br 0.20400(10) 0.12998(13) 0.32539(9) 0.0417(4) Uani 1 1 d . . . . .
Br2 Br 0.31233(10) 0.32822(11) 0.53966(9) 0.0321(4) Uani 1 1 d . . . . .
Cl1 Cl 0.3002(2) 0.1043(3) 0.7064(2) 0.0344(8) Uani 1 1 d . . . . .
Cl2 Cl 0.6508(2) 0.1167(3) 1.0935(2) 0.0330(8) Uani 1 1 d . . . . .
S1 S 0.6561(2) 0.1187(3) 0.4719(2) 0.0276(8) Uani 1 1 d . . . . .
N1 N 0.4631(7) 0.1328(8) 0.4331(6) 0.024(2) Uani 1 1 d . . . . .
N2 N 0.4740(7) 0.1238(8) 0.6254(6) 0.026(2) Uani 1 1 d . . . . .
O1 O 0.7594(6) 0.2954(7) 0.8354(6) 0.030(2) Uiso 1 1 d . . . . .
N3 N 0.6044(7) 0.1208(8) 0.7915(7) 0.028(2) Uiso 1 1 d . . . . .
N4 N 0.9134(11) 0.2455(12) 0.8438(11) 0.077(4) Uiso 1 1 d D . . . .
C1 C 0.4670(9) 0.1348(10) 0.3347(9) 0.027(3) Uiso 1 1 d . . . . .
H1 H 0.4065 0.1413 0.2689 0.035 Uiso 1 1 calc R U . . .
C2 C 0.5624(8) 0.1268(9) 0.3407(8) 0.021(2) Uiso 1 1 d . . . . .
H2 H 0.5761 0.1257 0.2812 0.027 Uiso 1 1 calc R U . . .
C3 C 0.5608(9) 0.1234(10) 0.5138(9) 0.028(3) Uiso 1 1 d . . . . .
C4 C 0.5669(9) 0.1230(11) 0.6219(9) 0.031(3) Uiso 1 1 d . . . . .
C5 C 0.6532(8) 0.1216(10) 0.7247(8) 0.024(3) Uiso 1 1 d . . . . .
C6 C 0.6553(8) 0.1156(9) 0.9048(8) 0.020(2) Uiso 1 1 d . . . . .
H6 H 0.7285 0.1125 0.9439 0.026 Uiso 1 1 calc R U . . .
C7 C 0.5928(9) 0.1151(11) 0.9544(9) 0.033(3) Uiso 1 1 d . . . . .
C8 C 0.4806(8) 0.1088(9) 0.8943(8) 0.026(3) Uiso 1 1 d . . . . .
H8 H 0.4398 0.1039 0.9307 0.033 Uiso 1 1 calc R U . . .
C9 C 0.4321(8) 0.1101(10) 0.7823(8) 0.025(3) Uiso 1 1 d . . . . .
C10 C 0.4969(8) 0.1166(9) 0.7308(8) 0.016(2) Uiso 1 1 d . . . . .
C11 C 0.7685(9) 0.1269(10) 0.7621(9) 0.031(3) Uiso 1 1 d . . . . .
H11A H 0.7831 0.1179 0.7007 0.040 Uiso 1 1 calc R U . . .
H11B H 0.8031 0.0706 0.8131 0.040 Uiso 1 1 calc R U . . .
C12 C 0.8121(9) 0.2316(10) 0.8161(8) 0.025(3) Uiso 1 1 d . . . . .
C13_a C 0.981(2) 0.3250(19) 0.9229(17) 0.038(7) Uiso 0.5 1 d D . P A 1
C14_a C 1.037(2) 0.313(3) 1.0494(18) 0.039(8) Uiso 0.5 1 d D . P A 1
C15_a C 0.963(3) 0.269(3) 1.094(3) 0.096(13) Uiso 0.5 1 d D . P A 1
C16_a C 0.9932(18) 0.1589(18) 0.8676(18) 0.037(7) Uiso 0.5 1 d D . P A 1
C17_a C 1.0264(15) 0.0721(15) 0.9527(15) 0.020(5) Uiso 0.5 1 d D . P A 1
C18_a C 1.067(2) -0.026(2) 0.920(2) 0.046(7) Uiso 0.5 1 d D . P A 1
C131_b C 0.9429(19) 0.3579(17) 0.8608(19) 0.047(8) Uiso 0.5 1 d D . P A 2
C141_b C 1.0394(16) 0.362(2) 0.9753(15) 0.026(6) Uiso 0.5 1 d D . P A 2
C151_b C 1.010(2) 0.330(3) 1.065(2) 0.050(9) Uiso 0.5 1 d D . P A 2
C161_b C 0.9680(19) 0.1886(19) 0.7926(18) 0.043(7) Uiso 0.5 1 d D . P A 2
C171_b C 1.0196(19) 0.0955(19) 0.8660(18) 0.036(6) Uiso 0.5 1 d D . P A 2
C181_b C 1.088(2) 0.027(3) 0.832(2) 0.060(9) Uiso 0.5 1 d D . P A 2


_geom_special_details            
;
 All esds (except the esd in the dihedral angle between two l.s. planes)
 are estimated using the full covariance matrix.  The cell esds are taken
 into account individually in the estimation of esds in distances, angles
 and torsion angles; correlations between esds in cell parameters are only
 used when they are defined by crystal symmetry.  An approximate (isotropic)
 treatment of cell esds is used for estimating esds involving l.s. planes.
;

loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
_geom_bond_site_symmetry_2
_geom_bond_publ_flag
Cu1 N2 1.994(8) . ?
Cu1 N1 2.017(9) . ?
Cu1 Br1 2.3218(18) . ?
Cu1 Br2 2.362(2) . ?
Cl1 C9 1.683(11) . ?
Cl2 C7 1.717(11) . ?
S1 C2 1.699(10) . ?
S1 C3 1.703(12) . ?
N1 C3 1.333(13) . ?
N1 C1 1.391(13) . ?
N2 C4 1.345(14) . ?
N2 C10 1.348(12) . ?
O1 C12 1.216(13) . ?
N3 C10 1.370(12) . ?
N3 C5 1.387(14) . ?
N3 C6 1.400(12) . ?
N4 C12 1.323(16) . ?
N4 C161_b 1.463(17) . ?
N4 C13_a 1.481(17) . ?
N4 C131_b 1.484(17) . ?
N4 C16_a 1.509(16) . ?
C1 C2 1.325(14) . ?
C1 H1 0.9300 . ?
C2 H2 0.9300 . ?
C3 C4 1.461(15) . ?
C4 C5 1.394(14) . ?
C5 C11 1.479(14) . ?
C6 C7 1.349(16) . ?
C6 H6 0.9300 . ?
C7 C8 1.426(15) . ?
C8 C9 1.383(13) . ?
C8 H8 0.9300 . ?
C9 C10 1.401(15) . ?
C11 C12 1.519(16) . ?
C11 H11A 0.9700 . ?
C11 H11B 0.9700 . ?
C13_a C14_a 1.568(18) . ?
C14_a C15_a 1.550(19) . ?
C16_a C17_a 1.527(17) . ?
C17_a C18_a 1.535(18) . ?
C131_b C141_b 1.554(17) . ?
C141_b C151_b 1.540(18) . ?
C161_b C171_b 1.517(18) . ?
C171_b C181_b 1.532(18) . ?

loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
_geom_angle_site_symmetry_1
_geom_angle_site_symmetry_3
_geom_angle_publ_flag
N2 Cu1 N1 80.9(4) . . ?
N2 Cu1 Br1 151.3(3) . . ?
N1 Cu1 Br1 98.2(2) . . ?
N2 Cu1 Br2 98.9(3) . . ?
N1 Cu1 Br2 131.0(3) . . ?
Br1 Cu1 Br2 102.95(7) . . ?
C2 S1 C3 90.3(5) . . ?
C3 N1 C1 109.4(9) . . ?
C3 N1 Cu1 113.2(7) . . ?
C1 N1 Cu1 136.1(7) . . ?
C4 N2 C10 106.5(8) . . ?
C4 N2 Cu1 112.1(7) . . ?
C10 N2 Cu1 139.4(8) . . ?
C10 N3 C5 110.4(8) . . ?
C10 N3 C6 123.2(10) . . ?
C5 N3 C6 126.1(9) . . ?
C12 N4 C161_b 122.8(16) . . ?
C12 N4 C13_a 123.9(16) . . ?
C12 N4 C131_b 111.6(15) . . ?
C161_b N4 C131_b 113(2) . . ?
C12 N4 C16_a 125.2(16) . . ?
C13_a N4 C16_a 99.9(17) . . ?
C2 C1 N1 115.8(9) . . ?
C2 C1 H1 122.1 . . ?
N1 C1 H1 122.1 . . ?
C1 C2 S1 110.7(8) . . ?
C1 C2 H2 124.7 . . ?
S1 C2 H2 124.7 . . ?
N1 C3 C4 114.4(10) . . ?
N1 C3 S1 113.8(8) . . ?
C4 C3 S1 131.7(9) . . ?
N2 C4 C5 112.6(10) . . ?
N2 C4 C3 115.9(9) . . ?
C5 C4 C3 131.5(11) . . ?
N3 C5 C4 102.0(9) . . ?
N3 C5 C11 125.4(9) . . ?
C4 C5 C11 132.5(10) . . ?
C7 C6 N3 116.7(10) . . ?
C7 C6 H6 121.6 . . ?
N3 C6 H6 121.6 . . ?
C6 C7 C8 121.6(11) . . ?
C6 C7 Cl2 118.8(9) . . ?
C8 C7 Cl2 119.6(9) . . ?
C9 C8 C7 120.5(11) . . ?
C9 C8 H8 119.7 . . ?
C7 C8 H8 119.7 . . ?
C8 C9 C10 117.7(10) . . ?
C8 C9 Cl1 123.0(9) . . ?
C10 C9 Cl1 119.2(8) . . ?
N2 C10 N3 108.2(9) . . ?
N2 C10 C9 131.8(10) . . ?
N3 C10 C9 119.9(9) . . ?
C5 C11 C12 110.6(10) . . ?
C5 C11 H11A 109.5 . . ?
C12 C11 H11A 109.5 . . ?
C5 C11 H11B 109.5 . . ?
C12 C11 H11B 109.5 . . ?
H11A C11 H11B 108.1 . . ?
O1 C12 N4 123.0(13) . . ?
O1 C12 C11 122.9(10) . . ?
N4 C12 C11 114.0(12) . . ?
N4 C13_a C14_a 126(2) . . ?
C15_a C14_a C13_a 113(2) . . ?
N4 C16_a C17_a 129.6(19) . . ?
C16_a C17_a C18_a 112.9(18) . . ?
N4 C131_b C141_b 104.3(17) . . ?
C151_b C141_b C131_b 112(2) . . ?
N4 C161_b C171_b 105.3(17) . . ?
C161_b C171_b C181_b 115(2) . . ?

loop_
_geom_torsion_atom_site_label_1
_geom_torsion_atom_site_label_2
_geom_torsion_atom_site_label_3
_geom_torsion_atom_site_label_4
_geom_torsion
_geom_torsion_site_symmetry_1
_geom_torsion_site_symmetry_2
_geom_torsion_site_symmetry_3
_geom_torsion_site_symmetry_4
_geom_torsion_publ_flag
C3 N1 C1 C2 0.3(16) . . . . ?
Cu1 N1 C1 C2 165.8(9) . . . . ?
N1 C1 C2 S1 -1.2(15) . . . . ?
C3 S1 C2 C1 1.4(10) . . . . ?
C1 N1 C3 C4 178.6(11) . . . . ?
Cu1 N1 C3 C4 9.5(14) . . . . ?
C1 N1 C3 S1 0.8(13) . . . . ?
Cu1 N1 C3 S1 -168.3(6) . . . . ?
C2 S1 C3 N1 -1.3(10) . . . . ?
C2 S1 C3 C4 -178.6(13) . . . . ?
C10 N2 C4 C5 -3.6(15) . . . . ?
Cu1 N2 C4 C5 163.2(9) . . . . ?
C10 N2 C4 C3 176.2(11) . . . . ?
Cu1 N2 C4 C3 -17.0(15) . . . . ?
N1 C3 C4 N2 5.0(17) . . . . ?
S1 C3 C4 N2 -177.7(10) . . . . ?
N1 C3 C4 C5 -175.2(13) . . . . ?
S1 C3 C4 C5 2(2) . . . . ?
C10 N3 C5 C4 3.0(14) . . . . ?
C6 N3 C5 C4 177.5(11) . . . . ?
C10 N3 C5 C11 179.4(11) . . . . ?
C6 N3 C5 C11 -6(2) . . . . ?
N2 C4 C5 N3 0.4(15) . . . . ?
C3 C4 C5 N3 -179.3(14) . . . . ?
N2 C4 C5 C11 -175.6(13) . . . . ?
C3 C4 C5 C11 5(2) . . . . ?
C10 N3 C6 C7 -5.6(18) . . . . ?
C5 N3 C6 C7 -179.6(13) . . . . ?
N3 C6 C7 C8 6.5(19) . . . . ?
N3 C6 C7 Cl2 -176.1(8) . . . . ?
C6 C7 C8 C9 -4(2) . . . . ?
Cl2 C7 C8 C9 178.3(10) . . . . ?
C7 C8 C9 C10 0.7(18) . . . . ?
C7 C8 C9 Cl1 -179.3(10) . . . . ?
C4 N2 C10 N3 5.4(13) . . . . ?
Cu1 N2 C10 N3 -155.7(10) . . . . ?
C4 N2 C10 C9 -177.4(14) . . . . ?
Cu1 N2 C10 C9 22(2) . . . . ?
C5 N3 C10 N2 -5.3(14) . . . . ?
C6 N3 C10 N2 179.9(10) . . . . ?
C5 N3 C10 C9 177.0(12) . . . . ?
C6 N3 C10 C9 2.2(18) . . . . ?
C8 C9 C10 N2 -176.7(12) . . . . ?
Cl1 C9 C10 N2 3(2) . . . . ?
C8 C9 C10 N3 0.3(18) . . . . ?
Cl1 C9 C10 N3 -179.7(9) . . . . ?
N3 C5 C11 C12 -66.0(16) . . . . ?
C4 C5 C11 C12 109.2(15) . . . . ?
C161_b N4 C12 O1 -159.7(15) . . . . ?
C13_a N4 C12 O1 15(2) . . . . ?
C131_b N4 C12 O1 -22(2) . . . . ?
C16_a N4 C12 O1 152.2(15) . . . . ?
C161_b N4 C12 C11 23(2) . . . . ?
C13_a N4 C12 C11 -162.3(16) . . . . ?
C131_b N4 C12 C11 160.7(14) . . . . ?
C16_a N4 C12 C11 -26(2) . . . . ?
C5 C11 C12 O1 7.5(16) . . . . ?
C5 C11 C12 N4 -174.8(11) . . . . ?
C12 N4 C13_a C14_a 83(3) . . . . ?
C161_b N4 C13_a C14_a -102(3) . . . . ?
C131_b N4 C13_a C14_a 162(5) . . . . ?
C16_a N4 C13_a C14_a -63(3) . . . . ?
N4 C13_a C14_a C15_a -47(4) . . . . ?
C12 N4 C16_a C17_a -59(3) . . . . ?
C161_b N4 C16_a C17_a -159(4) . . . . ?
C13_a N4 C16_a C17_a 86(3) . . . . ?
C131_b N4 C16_a C17_a 114(3) . . . . ?
N4 C16_a C17_a C18_a 153(2) . . . . ?
C12 N4 C131_b C141_b 127.4(16) . . . . ?
C161_b N4 C131_b C141_b -90(2) . . . . ?
C13_a N4 C131_b C141_b 8(2) . . . . ?
C16_a N4 C131_b C141_b -47(3) . . . . ?
N4 C131_b C141_b C151_b -65(3) . . . . ?
C12 N4 C161_b C171_b -95(2) . . . . ?
C13_a N4 C161_b C171_b 89(2) . . . . ?
C131_b N4 C161_b C171_b 126.8(19) . . . . ?
C16_a N4 C161_b C171_b 12(2) . . . . ?
N4 C161_b C171_b C181_b -177(2) . . . . ?

_refine_diff_density_max         2.269
_refine_diff_density_min         -1.157
_refine_diff_density_rms         0.216

_shelxl_version_number           2014-1



_exptl_crystal_recrystallization_method 'Re-crystallisation from solvent'
