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Caption : figure s1  the root mean square deviation (rmsd) of the fgfr1/fgfr4 and their ligands’ backbone heavy atoms along the 50 ns conventional md simulations.

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Caption : figure s2  molecular modeling analysis of azd4547 to the activity cavity of fgfr1/4. (a) alignment of crystal structure fgfr1/azd4547 (yellow) and binding pose of fgfr1/azd4547 (green) by molecular docking; (b) the alignment of last snapshots between fgfr1/azd4547(yellow) and fgfr4/azd4547(green) from conventional md trajectories.