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["Data set S4"]
[]
["This data set contains the experimental data from labeled cultures at 24h, used to fit the model."]
[]
["MMIDs"]
["This describes the carbon-nitrogen mass isotopomers measured by LC-MS. Columns are as follows:"]
[]
["Metabolite ID","Metabolite identifier (see dataset S5)"]
["In model","TRUE if metabolite is used in model fitting, otherwise FALSE"]
["C","Carbon mass isotopomer number, starting at 0"]
["N","Nitrogen mass isotopomer number, starting at 0"]
["Rep n","Replicate number n at each time point. Replicates are independent cell cultures."]
[]
["Fluxes"]
["This describes the boundary fluxes used to fit the model."]
["Standard deviations were only used to weight errors in the objective functions."]

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["Metabolite ID","In model","C","N","Rep 1","Rep 2","Rep 3"]
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["arg-L",true,0,3,0,0,0]
["arg-L",true,0,4,0.000101417688405159,0.000122425992282383,0.000159762840847154]
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["lac-L",true,3,0,0.464618872989152,0.480342271138845,0.345468595739796]
["mal-L",true,0,0,0.35431514809329,0.343148989849322,0.34420666675828]
["mal-L",true,1,0,0.0347032058716589,0.0348263801606019,0.034161302362241]
["mal-L",true,2,0,0.0963297850998217,0.0987998703219539,0.096851788869017]
["mal-L",true,3,0,0.0777380698906358,0.0784026772913169,0.0772831308725684]
["mal-L",true,4,0,0.436913791044593,0.444822082376805,0.447497111137892]
["pyr",true,0,0,0.393885730146667,0.400679149823377,0.41341737991558]
["pyr",true,1,0,0,0.000762877907988378,0]
["pyr",true,2,0,0,0,0]
["pyr",true,3,0,0.606114269853332,0.598557972268634,0.586582620084419]
["r5p",true,0,0,0.071593726284281,0,0.045852352143262]
["r5p",true,1,0,0,0,0]
["r5p",true,2,0,0.080852122717918,0.0677317195958029,0.20352549309605]
["r5p",true,3,0,0.119295492132596,0.0767900427173603,0.127946031039985]
["r5p",true,4,0,0,0,0]
["r5p",true,5,0,0.728258658865204,0.855478237686836,0.622676123720701]
["succ",true,0,0,0.608951760466591,0.569525802201249,0.539909163339117]
["succ",true,1,0,0.0320584076903509,0.0314478986608556,0.0290637641303117]
["succ",true,2,0,0.054267829568726,0.0600178018737247,0.0655720260540891]
["succ",true,3,0,0.0184438704201945,0.0196336686406976,0.0216809723627982]
["succ",true,4,0,0.286278131854137,0.319374828623472,0.343774074113683]
["udpg",true,0,0,0.155320403966586,0.0696598813720479,0.0368782626771174]
["udpg",true,0,1,0,0,0]
["udpg",true,0,2,0,0,0]
["udpg",true,1,0,0.00214965533512459,0,0]
["udpg",true,1,1,0,0,0.00170381527060384]
["udpg",true,1,2,0,0,0]
["udpg",true,2,0,0.00271277752054179,0,0]
["udpg",true,2,1,0,0.00241338463249898,0]
["udpg",true,2,2,0,0.00219545318324117,0]
["udpg",true,3,0,0.00211042589671715,0.00250323696852974,0]
["udpg",true,3,1,0.00983794059917957,0.0138466919978632,0.0109050751450039]
["udpg",true,3,2,0,0,0.0033379617366235]
["udpg",true,4,0,0,0.00288737338221859,0]
["udpg",true,4,1,0.00442339321503513,0.00280272931086899,0.00255622795113751]
["udpg",true,4,2,0,0,0]
["udpg",true,5,0,0.00902227090633324,0.00574815206039087,0.00829322025682318]
["udpg",true,5,1,0,0.00989997905396862,0]
["udpg",true,5,2,0.00247838775279282,0,0]
["udpg",true,6,0,0.179254258479426,0.16200570081092,0.192163873082434]
["udpg",true,6,1,0.0372385707928251,0.0671131106515883,0.0323808593685728]
["udpg",true,6,2,0,0,0.00252112582886977]
["udpg",true,7,0,0,0,0]
["udpg",true,7,1,0.0381790772818738,0.024375184949399,0.0359486066635939]
["udpg",true,7,2,0,0,0]
["udpg",true,8,0,0,0,0]
["udpg",true,8,1,0.0964686276686303,0.0964883213542386,0.124463109830396]
["udpg",true,8,2,0.0150463297855822,0.0201441793996362,0.00345975518508083]
["udpg",true,9,0,0,0,0]
["udpg",true,9,1,0.0592858517255721,0.0669050719640681,0.0734608281071799]
["udpg",true,9,2,0.00375324563679166,0,0.00454559898310348]
["udpg",true,10,0,0,0,0]
["udpg",true,10,1,0.0369159346771907,0.0606236416660781,0.0291691158943888]
["udpg",true,10,2,0,0,0]
["udpg",true,11,0,0,0,0]
["udpg",true,11,1,0.154387559411877,0.180533571192918,0.159464343973481]
["udpg",true,11,2,0.0214901342054014,0.0243707742216511,0.066842594633102]
["udpg",true,12,0,0,0,0]
["udpg",true,12,1,0.0214541577654343,0.0120933081580422,0.0116271976564542]
["udpg",true,12,2,0,0.00921641758193541,0]
["udpg",true,13,0,0,0,0]
["udpg",true,13,1,0.0468257532294885,0.0487587810025047,0.047741758010084]
["udpg",true,13,2,0,0,0]
["udpg",true,14,0,0,0,0.00224588012067198]
["udpg",true,14,1,0.0775784758701633,0.0612962441063591,0.113582239725669]
["udpg",true,14,2,0.0240667682774313,0.0541188109790313,0.0367085498996052]
["udpg",true,15,0,0,0,0]
["udpg",true,15,1,0,0,0]
["udpg",true,15,2,0,0,0]

{"sheet":"Fluxes","index":2,"n_rows":12,"n_cols":5,"rows_kept":12,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["Boundary flux","mean","std. dev","Comment","Reference PubMed ID"]
["ac_OUT",32,3.2,"Based on cell composition",7765929]
["ala-L_OUT",20,10,"Estimated from NCI-60 data (uncertain)",22628656]
["asp-L_IN",5,2.5,"Estimated from NCI-60 data (uncertain)",22628656]
["citr-L_IN",1,0.1,"Only for scaling"]
["gln-L_IN",160.5,4.3,"Measured (see Methods)"]
["glu-L_OUT",84.7,2.1,"Measured (see Methods)"]
["glycogen_OUT",6.51,0.65,"Based on cell composition",7765929]
["gthrd_OUT",0.5,2.5,"Based on cell glutathione content",24251119]
["lac-L_OUT",657.7,15.5,"Measured (see Methods)"]
["protein_OUT",80.3,8.03,"Based on cell composition",7765929]
["rna_OUT",1.8,0.18,"Based on cell composition",7765929]