{"text_format":"2","workbook":"xls","n_sheets":3,"sheets":["Sheet1","Sheet2","Sheet3"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":0,"defined_names":0,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Sheet1","index":0,"n_rows":42,"n_cols":14,"rows_kept":42,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}
["Table S2. Importance of each target protein in the pathway network."]
["The influences of the pathway network after knocking out each target were calculated by NEd and NFd for the whole network and each inflammatory factor, respectively."]
["UniProt ID","Target","NEd","IL-1-beta","IL-6","IL-10","IL-12","IL-17","IL-23","IL-27","NO","PGE2","TNF-alpha","IFN-gamma"]
["O00206","TLR4",3.005481561055628,6.5856833407006725,7.209605278946938,1.9180711070232928,6.029091686228412,2.5004503073808233,4.159536322549225,4.56520510822812,2.081748997008253,2.5965308715839086,2.9348177093293724,3.0890823812595167]
["O14684","PGES-1",12.62806436563825,10.891968754913538,7.719831597155405,2.955611158271081,6.455771802049864,4.472964035896919,5.988402355796192,6.57244099771956,3.442970785711336,99.99475409288918,4.763994311335777,5.014407145216062]
["O14920","IKK",7.064356994243573,7.9599559747755695,5.447564860452945,6.652008460713732,7.90867575802076,9.762924417031437,8.784016818208668,17.76203534962482,7.593867618876921,4.9410573276437555,7.562926438054732,7.960461304390554]
["O43318","TAK1",5.735949631025766,10.750262836347126,6.512945487559982,4.080875584111013,5.446505351754607,5.231407401587656,4.961127870240228,7.855919274931621,3.57051273213572,2.2320600793113146,5.304506483229424,5.430136628212376]
["O60674","JAK2",12.491993202816102,0.7455589325867638,0,12.622248261977589,0,16.467515855990623,12.038988264267712,16.76114010979248,10.405822177491618,9.738698199178213,19.732401197183336,10.511944708622167]
["P01116","Ras",3.3975885299191293,0,0,2.7333296579382904,3.9770345110692276,2.2194480857156047,3.689103751144617,2.416292184306886,2.9433568168971336,2.7127829544948847,4.182230067451155,3.0890823812595167]
["P01375","TNFα",9.959789993155917,0,0,1.766403990063655,0,2.302724261073672,0,0,1.846325120979419,1.630882214783358,0,0]
["P01584","IL-1β",5.096992722949379,0,8.169691676534322,2.875990915610529,6.8319584199594106,2.9907403708062734,4.908636828952758,4.8428005357223105,2.771021466091291,3.105661994847737,3.9050011238657123,4.110262157743564]
["P04049","Raf",5.116360326902783,0,0,3.6844579756814406,3.9770345110692276,3.022561348382119,3.689103751144617,2.416292184306886,3.9280672245736445,3.571141608279228,7.008739256690745,4.532333744283257]
["P05231","IL-6",6.125484263514518,0,0,1.0894350312859418,2.258894730819477,2.3027168210508635,2.09536070082896,2.299709815074127,1.2009912729378323,1.1460027887520328,1.6669364992290086,1.7545567324600122]
["P05412","AP-1",18.69520510898401,38.35923388084273,33.177276370395695,17.34698571378513,31.721726510790425,9.66262546947474,30.378756561654583,10.42226141364526,19.748307666855087,9.331479830993713,28.241365838289422,26.881005868651737]
["P17252","PKC",4.702811216904393,0,0,5.3874728154884455,0,0,0,0,0,0,0,0]
["P19438","TNFR1",2.3530984180125047,0,0,1.1413756684054064,0,1.4879301625890482,0,0,1.1488425957839876,0.9656641086624402,0,0]
["P19838","NF-kB",19.09136985843518,21.64986425846567,17.239414823887937,24.193071012855558,17.76968787870864,22.561504622597774,25.793781556918105,83.98544726271176,16.866702052858702,14.973248191514083,29.962888853609805,15.619810562286307]
["P23458","JAK1",0.777940702611466,0,0,0.47554703746609867,0,0.35421204615581514,0,0,1.890587732480388,0.5149873789192049,0.5456992444513573,0.5743831775795392]
["P25963","IκBα",13.082174219162091,14.38086093433006,10.164268054401504,17.89042483115156,11.853061672713386,12.24285514149101,20.305504007299138,39.14644887597465,11.486144237795214,11.224139763944995,25.596753486385147,11.024184462930918]
["P27361","ERK1",12.111320864281309,11.110830035112446,8.725737469972533,12.591155789608981,11.273966217518698,5.269373838007938,10.457791692453,5.719812701996689,7.440220313512473,6.498790428251438,12.393479448102468,10.200124617738904]
["P29597","TYK2",1.900357631230756,0,0,0.6340684237566204,0,2.479930724459574,1.2195330778081601,1.3384745069886135,0.6892724690830382,0.6437477440281647,0.9701834145363402,4.442441320146541]
["P31749","PKB/Akt",4.736078043232247,0.8467244844842134,0.6522412204338561,3.028194503275503,6.157437708809301,5.204370358681269,6.330197847977074,9.507047047015698,3.235933988667228,2.301037190777345,5.03590519568275,5.300610652656684]
["P35228","iNOS",6.129367749805918,0,0,3.7276438674606984,0,2.4334231418487176,0,0,99.99566404257372,3.7795485954875607,3.9444717769984963,4.1518075316799585]
["P35354","COX-2",13.116221087240962,6.729133868913959,4.73277821675924,1.6082022033422718,3.957828758289507,2.7164341696737293,3.671299387077651,4.029350277071354,2.1270869810982536,88.4060044699146,2.920653682917573,3.074173842205339]
["P42224","STAT1",2.811747332786072,0,0,0.9943142095224085,0,0.7261462266547888,0,0,3.269201604786784,1.066765640992676,1.127777856369777,1.1870579542341004]
["P42336","PI3K",4.660068055913478,0.8467244844842134,0.6522412204338561,1.8868302491404345,3.7908700608347905,3.3444390553879177,4.134959274986991,7.097706193394695,2.087105179711306,1.335380808045843,3.289512175910568,3.462420876513633]
["P42345","mTOR",0.9219364778264818,0,0,0.47554703746609867,1.3147124704739617,3.5139971753209402,0.9146305989620896,1.0038347973494262,0.6266113355300313,0.6437477440281647,0.7276222791228302,0.7658687473178285]
["P45983","JNK",4.079736706631124,7.995676857295078,6.367463701013632,4.660606373979672,5.3248334170158245,2.990747810829082,4.93934990580812,2.299709815074127,4.660995684722816,3.893320654565588,3.929434506048348,4.1359798471847276]
["P45985","MKK4",1.1945352043698216,3.6343708163443003,2.829968144285777,1.1413756684054064,2.366591314952678,0.743927881180455,2.1952605265832843,1.0951056487814212,1.1488357023699607,0.9656641086624402,1.7464104846629351,1.8382081590518746]
["P52333","JAK3",2.002373700697192,0,0,1.4112318474578758,2.9261141792061114,6.423246976244525,2.714276399689761,4.2509856854391455,1.461355520935296,1.260601522441043,2.1593066997242043,2.2728076979533745]
["P52564","MKK6",1.2801211133812909,3.6343708163443003,2.829968144285777,1.426732426560878,2.366591314952678,0.743927881180455,2.1952605265832843,1.0951056487814212,1.1488357023699607,1.1036260575254255,1.7464104846629351,1.8382081590518746]
["P53778","p38",2.5712619904415086,7.995676857295078,6.367463701013632,4.644854680929479,5.3248334170158245,1.5705218558482166,4.93934990580812,2.299709815074127,2.527449574676357,2.7437871153722573,3.929434506048348,4.1359798471847276]
["P62993","GRB2",2.0339726312165194,0,0,1.2047305758510836,2.4979548772494304,1.0272885900777315,2.3171029687185607,1.555881289583879,1.3158838046130696,1.2379722707067264,1.8433406284182041,1.9402333030107224]
["Q01970","PLCβ",4.136005689618414,0,0,1.528587667816889,0,0,0,0,0,0,0,0]
["Q02750","MEK1",6.85438355430152,6.7495239941616685,5.188241913244678,5.776944840424511,8.315735948944646,4.442772423317354,7.713713290024764,4.515208535704005,6.061613334620104,5.395156644795074,10.21046415916243,7.902352929606052]
["Q13153","PAK1",1.018210284388024,0,0,1.1413756684054064,0,0.6762906337776016,0,0,0.9847104076765111,0.9656641086624402,0,0]
["Q13546","RIP1",2.7416953009626828,4.7693702373519695,3.68297734327418,2.436547215186289,3.0799140368019082,3.052358639752529,1.8293599890934624,2.0077780210007163,2.4923207367680944,2.124754624433232,2.2728022923716984,2.239084251720484]
["Q13976","PKG",5.7234279046027545,0,0,9.14920540127838,0,2.4334231418487176,0,0,0,7.994793340618375,3.9444717769984963,4.1518075316799585]
["Q96PN6","AC",2.0569332536267178,0,0,1.8979991126546243,0,0,0,0,0,0,0,0]
["Q99558","NIK",2.9651116303576557,0,0,3.043649425297194,0,3.9678013668661145,0,0,3.1182634111369976,2.6823891421620796,0,0]
["Q9UHD2","TBK1",4.369188753533551,0,0,4.653866247352046,0,6.562940844601808,1.5550498423402703,8.734112083159596,4.398708174210354,3.441979494761205,1.8433493608635811,2.1700288547328412]
["Q9Y4K3","TRAF6",9.374313903146577,6.446637951845729,15.020127739829151,3.7693002470162322,13.312024375094156,4.112718131238877,3.789398741576133,7.206240921556089,2.899404409027616,6.615212481643187,3.3123125908065125,3.4864197639799905]

{"sheet":"Sheet2","index":1,"n_rows":0,"n_cols":0,"rows_kept":0,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}

{"sheet":"Sheet3","index":2,"n_rows":0,"n_cols":0,"rows_kept":0,"cut":false,"hidden":false,"merged":[],"flags":["formulas_cached_only"]}