# Electronic Supplementary Material (ESI) for RSC Advances.
# This journal is © The Royal Society of Chemistry 2016

####################################################################### 
# 
# This file contains crystal structure data downloaded from the 
# Cambridge Structural Database (CSD) hosted by the Cambridge 
# Crystallographic Data Centre (CCDC).
# 
# Full information about CCDC data access policies and citation 
# guidelines are available at http://www.ccdc.cam.ac.uk/access/V1 
# 
# Audit and citation data items may have been added by the CCDC. 
# Please retain this information to preserve the provenance of 
# this file and to allow appropriate attribution of the data. 
# 
#######################################################################

data_4meom
_database_code_depnum_ccdc_archive 'CCDC 1434825'
_audit_update_record             
;
2015-11-03 deposited with the CCDC.
2016-05-10 downloaded from the CCDC.
;

_audit_creation_method           SHELXL-97
_chemical_name_systematic        
; 
 ? 
;
_chemical_name_common            ?
_chemical_melting_point          ?
_chemical_formula_moiety         ?
_chemical_formula_sum            'C31 H26 N2 O5'
_chemical_formula_weight         506.54

loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
N N 0.0061 0.0033 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'

_symmetry_cell_setting           ORTHORHOMBIC
_symmetry_space_group_name_H-M   P212121

loop_
_symmetry_equiv_pos_as_xyz
'x, y, z'
'-x+1/2, -y, z+1/2'
'-x, y+1/2, -z+1/2'
'x+1/2, -y+1/2, -z'

_cell_length_a                   9.1140(16)
_cell_length_b                   13.231(2)
_cell_length_c                   22.242(4)
_cell_angle_alpha                90.00
_cell_angle_beta                 90.00
_cell_angle_gamma                90.00
_cell_volume                     2682.1(8)
_cell_formula_units_Z            4
_cell_measurement_temperature    150(2)
_cell_measurement_reflns_used    2700
_cell_measurement_theta_min      2.39
_cell_measurement_theta_max      23.44

_exptl_crystal_description       PLATES
_exptl_crystal_colour            COLOURLESS
_exptl_crystal_size_max          0.11
_exptl_crystal_size_mid          0.08
_exptl_crystal_size_min          0.04
_exptl_crystal_density_meas      ?
_exptl_crystal_density_diffrn    1.254
_exptl_crystal_density_method    'not measured'
_exptl_crystal_F_000             1064
_exptl_absorpt_coefficient_mu    0.086
_exptl_absorpt_correction_type   MULTI-SCAN
_exptl_absorpt_correction_T_min  0.9906
_exptl_absorpt_correction_T_max  0.9966
_exptl_absorpt_process_details   'BRUKER SADABS'

_exptl_special_details           
; 
 ? 
;

_diffrn_ambient_temperature      150(2)
_diffrn_radiation_wavelength     0.71073
_diffrn_radiation_type           MoK\a
_diffrn_radiation_source         'fine-focus sealed tube'
_diffrn_radiation_monochromator  graphite
_diffrn_measurement_device_type  'BRUKER SMART APEX CCD DIFFRACTOMETER'
_diffrn_measurement_method       'OMEGA-PHI SCAN'
_diffrn_detector_area_resol_mean ?
_diffrn_standards_number         ?
_diffrn_standards_interval_count ?
_diffrn_standards_interval_time  ?
_diffrn_standards_decay_%        ?
_diffrn_reflns_number            13431
_diffrn_reflns_av_R_equivalents  0.0614
_diffrn_reflns_av_sigmaI/netI    0.0787
_diffrn_reflns_limit_h_min       -9
_diffrn_reflns_limit_h_max       10
_diffrn_reflns_limit_k_min       -15
_diffrn_reflns_limit_k_max       12
_diffrn_reflns_limit_l_min       -20
_diffrn_reflns_limit_l_max       26
_diffrn_reflns_theta_min         1.83
_diffrn_reflns_theta_max         24.99
_reflns_number_total             4715
_reflns_number_gt                3936
_reflns_threshold_expression     >2sigma(I)

_computing_data_collection       'BRUKER SMART'
_computing_cell_refinement       'BRUKER SMART'
_computing_data_reduction        'BRUKER SAINT'
_computing_structure_solution    'SHELXS-97 (Sheldrick, 1990)'
_computing_structure_refinement  'SHELXL-97 (Sheldrick, 1997)'
_computing_molecular_graphics    ORTEP
_computing_publication_material  ?

_refine_special_details          
; 
 Refinement of F² against ALL reflections.  The weighted R-factor wR and 
 goodness of fit S are based on F², conventional R-factors R are based 
 on F, with F set to zero for negative F². The threshold expression of 
 F² > 2sigma(F²) is used only for calculating R-factors(gt) etc. and is 
 not relevant to the choice of reflections for refinement.  R-factors based 
 on F² are statistically about twice as large as those based on F, and R- 
 factors based on ALL data will be even larger. 
;

_refine_ls_structure_factor_coef Fsqd
_refine_ls_matrix_type           full
_refine_ls_weighting_scheme      calc
_refine_ls_weighting_details     
'calc w=1/[σ²(Fo²)+(0.0508P)²+0.0000P] where P=(Fo²+2Fc²)/3'
_atom_sites_solution_primary     direct
_atom_sites_solution_secondary   difmap
_atom_sites_solution_hydrogens   geom
_refine_ls_hydrogen_treatment    mixed
_refine_ls_extinction_method     none
_refine_ls_extinction_coef       ?
_refine_ls_abs_structure_details 'Flack H D (1983), Acta Cryst. A39, 876-881'
_refine_ls_abs_structure_Flack   1.9(18)
_refine_ls_number_reflns         4715
_refine_ls_number_parameters     351
_refine_ls_number_restraints     0
_refine_ls_R_factor_all          0.0987
_refine_ls_R_factor_gt           0.0803
_refine_ls_wR_factor_ref         0.1418
_refine_ls_wR_factor_gt          0.1360
_refine_ls_goodness_of_fit_ref   1.220
_refine_ls_restrained_S_all      1.220
_refine_ls_shift/su_max          0.000
_refine_ls_shift/su_mean         0.000

loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_symmetry_multiplicity
_atom_site_calc_flag
_atom_site_refinement_flags
_atom_site_disorder_assembly
_atom_site_disorder_group
O3 O 0.1660(3) -0.13308(19) 0.83720(12) 0.0370(7) Uani 1 1 d . . .
O1 O 0.4331(3) -0.21164(17) 0.69051(12) 0.0286(6) Uani 1 1 d . . .
O4 O 0.1053(3) 0.00875(17) 0.78796(11) 0.0294(6) Uani 1 1 d . . .
O5 O 0.4098(3) 0.10295(18) 0.73613(12) 0.0349(7) Uani 1 1 d . . .
C9 C 0.4406(4) -0.1478(3) 0.64150(17) 0.0232(9) Uani 1 1 d . . .
C11 C 0.2608(4) -0.1019(2) 0.73902(17) 0.0218(8) Uani 1 1 d . . .
C20 C 0.3000(4) 0.0801(3) 0.70763(17) 0.0242(9) Uani 1 1 d . . .
C29 C 0.1770(4) -0.0798(3) 0.79233(18) 0.0232(9) Uani 1 1 d . . .
N1 N 0.3549(4) -0.2563(3) 0.78054(17) 0.0340(9) Uani 1 1 d . . .
O2 O 0.4860(3) 0.0238(2) 0.48673(12) 0.0482(8) Uani 1 1 d . . .
C12 C 0.2575(4) -0.0273(2) 0.68642(17) 0.0237(9) Uani 1 1 d . . .
C13 C 0.3641(4) -0.0601(3) 0.63816(17) 0.0228(9) Uani 1 1 d . . .
C8 C 0.5340(4) -0.1819(3) 0.59401(18) 0.0264(9) Uani 1 1 d . . .
C5 C 0.7085(5) -0.2467(4) 0.4985(2) 0.0517(13) Uani 1 1 d . . .
H5 H 0.7658 -0.2691 0.4666 0.062 Uiso 1 1 calc R . .
C1 C 0.3804(4) -0.0001(3) 0.58518(17) 0.0281(9) Uani 1 1 d . . .
H1 H 0.3296 0.0606 0.5825 0.034 Uiso 1 1 calc R . .
C19 C 0.0796(4) 0.0946(3) 0.66031(17) 0.0272(9) Uani 1 1 d . . .
C3 C 0.5464(4) -0.1220(3) 0.54164(18) 0.0293(10) Uani 1 1 d . . .
C14 C 0.1083(4) -0.0077(3) 0.65927(16) 0.0219(9) Uani 1 1 d . . .
N2 N 0.1978(3) 0.1465(2) 0.68820(14) 0.0256(8) Uani 1 1 d . . .
C2 C 0.4670(4) -0.0284(3) 0.53874(18) 0.0330(10) Uani 1 1 d . . .
C10 C 0.3466(4) -0.1864(3) 0.73799(17) 0.0231(9) Uani 1 1 d . . .
C30 C 0.0112(5) 0.0372(3) 0.83763(18) 0.0370(11) Uani 1 1 d . . .
H30A H 0.0692 0.0497 0.8734 0.044 Uiso 1 1 calc R . .
H30B H -0.0583 -0.0164 0.8463 0.044 Uiso 1 1 calc R . .
C7 C 0.6135(4) -0.2735(3) 0.5975(2) 0.0341(10) Uani 1 1 d . . .
H7 H 0.6082 -0.3127 0.6321 0.041 Uiso 1 1 calc R . .
C21 C 0.1962(5) 0.2526(3) 0.70674(19) 0.0400(11) Uani 1 1 d . . .
H21A H 0.2415 0.2580 0.7461 0.048 Uiso 1 1 calc R . .
H21B H 0.0950 0.2744 0.7106 0.048 Uiso 1 1 calc R . .
C4 C 0.6357(4) -0.1574(4) 0.49390(19) 0.0420(12) Uani 1 1 d . . .
H4 H 0.6446 -0.1190 0.4591 0.050 Uiso 1 1 calc R . .
C6 C 0.6982(5) -0.3048(4) 0.5502(2) 0.0501(13) Uani 1 1 d . . .
H6 H 0.7493 -0.3655 0.5528 0.060 Uiso 1 1 calc R . .
C22 C 0.2742(4) 0.3230(3) 0.6641(2) 0.0322(10) Uani 1 1 d . . .
C28 C 0.4142(7) 0.1190(3) 0.4819(2) 0.0657(16) Uani 1 1 d . . .
H28A H 0.4493 0.1633 0.5129 0.098 Uiso 1 1 calc R . .
H28B H 0.3103 0.1097 0.4864 0.098 Uiso 1 1 calc R . .
H28C H 0.4345 0.1480 0.4433 0.098 Uiso 1 1 calc R . .
C17 C -0.1505(5) 0.0657(4) 0.6123(2) 0.0524(14) Uani 1 1 d . . .
H17 H -0.2385 0.0897 0.5967 0.063 Uiso 1 1 calc R . .
C16 C -0.1211(5) -0.0373(4) 0.6106(2) 0.0505(13) Uani 1 1 d . . .
H16 H -0.1887 -0.0816 0.5937 0.061 Uiso 1 1 calc R . .
C23 C 0.3498(5) 0.4048(3) 0.6873(2) 0.0479(13) Uani 1 1 d . . .
H23 H 0.3549 0.4139 0.7287 0.057 Uiso 1 1 calc R . .
C27 C 0.2681(5) 0.3107(3) 0.6023(2) 0.0495(13) Uani 1 1 d . . .
H27 H 0.2182 0.2558 0.5860 0.059 Uiso 1 1 calc R . .
C31 C -0.0680(7) 0.1313(3) 0.8191(2) 0.0755(19) Uani 1 1 d . . .
H31A H -0.1188 0.1195 0.7819 0.113 Uiso 1 1 calc R . .
H31B H 0.0013 0.1852 0.8138 0.113 Uiso 1 1 calc R . .
H31C H -0.1375 0.1497 0.8497 0.113 Uiso 1 1 calc R . .
C26 C 0.3359(6) 0.3797(4) 0.5647(2) 0.0688(16) Uani 1 1 d . . .
H26 H 0.3307 0.3715 0.5232 0.083 Uiso 1 1 calc R . .
C15 C 0.0084(4) -0.0738(3) 0.63413(19) 0.0357(11) Uani 1 1 d . . .
H15 H 0.0284 -0.1426 0.6331 0.043 Uiso 1 1 calc R . .
C18 C -0.0506(5) 0.1334(3) 0.6368(2) 0.0404(11) Uani 1 1 d . . .
H18 H -0.0699 0.2024 0.6376 0.049 Uiso 1 1 calc R . .
C24 C 0.4174(6) 0.4731(4) 0.6496(3) 0.0675(16) Uani 1 1 d . . .
H24 H 0.4676 0.5280 0.6657 0.081 Uiso 1 1 calc R . .
C25 C 0.4111(6) 0.4604(4) 0.5888(3) 0.0677(16) Uani 1 1 d . . .
H25 H 0.4576 0.5064 0.5635 0.081 Uiso 1 1 calc R . .
H1B H 0.424(5) -0.303(3) 0.776(2) 0.050 Uiso 1 1 d . . .
H1A H 0.313(5) -0.246(3) 0.816(2) 0.050 Uiso 1 1 d . . .


_geom_special_details            
; 
 All esds (except the esd in the dihedral angle between two l.s. planes) 
 are estimated using the full covariance matrix.  The cell esds are taken 
 into account individually in the estimation of esds in distances, angles 
 and torsion angles; correlations between esds in cell parameters are only 
 used when they are defined by crystal symmetry.  An approximate (isotropic) 
 treatment of cell esds is used for estimating esds involving l.s. planes. 
;

loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
_geom_bond_site_symmetry_2
_geom_bond_publ_flag
O3 C29 1.226(4) . ?
O1 C10 1.360(4) . ?
O1 C9 1.381(4) . ?
O4 C29 1.345(4) . ?
O4 C30 1.448(4) . ?
O5 C20 1.222(4) . ?
C9 C13 1.356(5) . ?
C9 C8 1.430(5) . ?
C11 C10 1.365(5) . ?
C11 C29 1.440(5) . ?
C11 C12 1.531(5) . ?
C20 N2 1.351(4) . ?
C20 C12 1.546(5) . ?
N1 C10 1.325(5) . ?
N1 H1B 0.89(4) . ?
N1 H1A 0.89(5) . ?
O2 C2 1.358(5) . ?
O2 C28 1.423(5) . ?
C12 C14 1.510(5) . ?
C12 C13 1.512(5) . ?
C13 C1 1.428(5) . ?
C8 C3 1.413(5) . ?
C8 C7 1.414(5) . ?
C5 C4 1.359(6) . ?
C5 C6 1.387(7) . ?
C5 H5 0.9300 . ?
C1 C2 1.352(5) . ?
C1 H1 0.9300 . ?
C19 C14 1.380(5) . ?
C19 C18 1.394(5) . ?
C19 N2 1.420(5) . ?
C3 C4 1.417(5) . ?
C3 C2 1.436(5) . ?
C14 C15 1.380(5) . ?
N2 C21 1.463(4) . ?
C30 C31 1.497(5) . ?
C30 H30A 0.9700 . ?
C30 H30B 0.9700 . ?
C7 C6 1.368(6) . ?
C7 H7 0.9300 . ?
C21 C22 1.508(6) . ?
C21 H21A 0.9700 . ?
C21 H21B 0.9700 . ?
C4 H4 0.9300 . ?
C6 H6 0.9300 . ?
C22 C23 1.383(5) . ?
C22 C27 1.386(6) . ?
C28 H28A 0.9600 . ?
C28 H28B 0.9600 . ?
C28 H28C 0.9600 . ?
C17 C16 1.390(6) . ?
C17 C18 1.390(6) . ?
C17 H17 0.9300 . ?
C16 C15 1.378(6) . ?
C16 H16 0.9300 . ?
C23 C24 1.378(6) . ?
C23 H23 0.9300 . ?
C27 C26 1.384(6) . ?
C27 H27 0.9300 . ?
C31 H31A 0.9600 . ?
C31 H31B 0.9600 . ?
C31 H31C 0.9600 . ?
C26 C25 1.378(7) . ?
C26 H26 0.9300 . ?
C15 H15 0.9300 . ?
C18 H18 0.9300 . ?
C24 C25 1.364(7) . ?
C24 H24 0.9300 . ?
C25 H25 0.9300 . ?

loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
_geom_angle_site_symmetry_1
_geom_angle_site_symmetry_3
_geom_angle_publ_flag
C10 O1 C9 119.5(3) . . ?
C29 O4 C30 117.3(3) . . ?
C13 C9 O1 122.8(3) . . ?
C13 C9 C8 122.4(3) . . ?
O1 C9 C8 114.8(3) . . ?
C10 C11 C29 118.9(3) . . ?
C10 C11 C12 121.8(3) . . ?
C29 C11 C12 119.2(3) . . ?
O5 C20 N2 124.7(3) . . ?
O5 C20 C12 126.2(3) . . ?
N2 C20 C12 109.1(3) . . ?
O3 C29 O4 121.3(3) . . ?
O3 C29 C11 126.6(3) . . ?
O4 C29 C11 112.0(3) . . ?
C10 N1 H1B 116(3) . . ?
C10 N1 H1A 120(3) . . ?
H1B N1 H1A 121(4) . . ?
C2 O2 C28 117.1(3) . . ?
C14 C12 C13 110.1(3) . . ?
C14 C12 C11 115.7(3) . . ?
C13 C12 C11 110.2(3) . . ?
C14 C12 C20 101.0(3) . . ?
C13 C12 C20 108.6(3) . . ?
C11 C12 C20 110.8(3) . . ?
C9 C13 C1 117.8(3) . . ?
C9 C13 C12 122.5(3) . . ?
C1 C13 C12 119.5(3) . . ?
C3 C8 C7 119.0(3) . . ?
C3 C8 C9 118.6(3) . . ?
C7 C8 C9 122.4(4) . . ?
C4 C5 C6 120.7(4) . . ?
C4 C5 H5 119.6 . . ?
C6 C5 H5 119.6 . . ?
C2 C1 C13 122.5(4) . . ?
C2 C1 H1 118.7 . . ?
C13 C1 H1 118.7 . . ?
C14 C19 C18 121.1(4) . . ?
C14 C19 N2 109.7(3) . . ?
C18 C19 N2 129.2(3) . . ?
C8 C3 C4 118.6(4) . . ?
C8 C3 C2 118.7(3) . . ?
C4 C3 C2 122.7(4) . . ?
C19 C14 C15 120.2(3) . . ?
C19 C14 C12 109.4(3) . . ?
C15 C14 C12 130.4(3) . . ?
C20 N2 C19 110.4(3) . . ?
C20 N2 C21 122.7(3) . . ?
C19 N2 C21 125.4(3) . . ?
C1 C2 O2 125.8(4) . . ?
C1 C2 C3 119.9(4) . . ?
O2 C2 C3 114.4(3) . . ?
N1 C10 O1 110.5(3) . . ?
N1 C10 C11 126.4(4) . . ?
O1 C10 C11 123.1(3) . . ?
O4 C30 C31 107.0(3) . . ?
O4 C30 H30A 110.3 . . ?
C31 C30 H30A 110.3 . . ?
O4 C30 H30B 110.3 . . ?
C31 C30 H30B 110.3 . . ?
H30A C30 H30B 108.6 . . ?
C6 C7 C8 120.4(4) . . ?
C6 C7 H7 119.8 . . ?
C8 C7 H7 119.8 . . ?
N2 C21 C22 114.2(3) . . ?
N2 C21 H21A 108.7 . . ?
C22 C21 H21A 108.7 . . ?
N2 C21 H21B 108.7 . . ?
C22 C21 H21B 108.7 . . ?
H21A C21 H21B 107.6 . . ?
C5 C4 C3 120.8(4) . . ?
C5 C4 H4 119.6 . . ?
C3 C4 H4 119.6 . . ?
C7 C6 C5 120.5(4) . . ?
C7 C6 H6 119.7 . . ?
C5 C6 H6 119.7 . . ?
C23 C22 C27 118.8(4) . . ?
C23 C22 C21 118.9(4) . . ?
C27 C22 C21 122.2(4) . . ?
O2 C28 H28A 109.5 . . ?
O2 C28 H28B 109.5 . . ?
H28A C28 H28B 109.5 . . ?
O2 C28 H28C 109.5 . . ?
H28A C28 H28C 109.5 . . ?
H28B C28 H28C 109.5 . . ?
C16 C17 C18 121.1(4) . . ?
C16 C17 H17 119.5 . . ?
C18 C17 H17 119.5 . . ?
C15 C16 C17 119.9(4) . . ?
C15 C16 H16 120.1 . . ?
C17 C16 H16 120.1 . . ?
C24 C23 C22 120.6(5) . . ?
C24 C23 H23 119.7 . . ?
C22 C23 H23 119.7 . . ?
C26 C27 C22 120.3(5) . . ?
C26 C27 H27 119.8 . . ?
C22 C27 H27 119.8 . . ?
C30 C31 H31A 109.5 . . ?
C30 C31 H31B 109.5 . . ?
H31A C31 H31B 109.5 . . ?
C30 C31 H31C 109.5 . . ?
H31A C31 H31C 109.5 . . ?
H31B C31 H31C 109.5 . . ?
C25 C26 C27 119.9(5) . . ?
C25 C26 H26 120.1 . . ?
C27 C26 H26 120.1 . . ?
C16 C15 C14 119.8(4) . . ?
C16 C15 H15 120.1 . . ?
C14 C15 H15 120.1 . . ?
C17 C18 C19 117.9(4) . . ?
C17 C18 H18 121.1 . . ?
C19 C18 H18 121.1 . . ?
C25 C24 C23 120.3(5) . . ?
C25 C24 H24 119.9 . . ?
C23 C24 H24 119.9 . . ?
C24 C25 C26 120.1(5) . . ?
C24 C25 H25 119.9 . . ?
C26 C25 H25 119.9 . . ?

_diffrn_measured_fraction_theta_max 0.999
_diffrn_reflns_theta_full        24.99
_diffrn_measured_fraction_theta_full 0.999
_refine_diff_density_max         0.266
_refine_diff_density_min         -0.200
_refine_diff_density_rms         0.050
