# Electronic Supplementary Material (ESI) for RSC Advances.
# This journal is © The Royal Society of Chemistry 2017

####################################################################### 
# 
# This file contains crystal structure data downloaded from the 
# Cambridge Structural Database (CSD) hosted by the Cambridge 
# Crystallographic Data Centre (CCDC).
# 
# Full information about CCDC data access policies and citation 
# guidelines are available at http://www.ccdc.cam.ac.uk/access/V1 
# 
# Audit and citation data items may have been added by the CCDC. 
# Please retain this information to preserve the provenance of 
# this file and to allow appropriate attribution of the data. 
# 
#######################################################################

data_m20160920e1
_database_code_depnum_ccdc_archive 'CCDC 1508810'
_audit_update_record             
;
2016-10-07 deposited with the CCDC.
2017-01-25 downloaded from the CCDC.
;

_audit_creation_method           SHELXL-97
_chemical_name_systematic        
; 
 ? 
;
_chemical_name_common            ?
_chemical_melting_point          ?
_chemical_formula_moiety         ?
_chemical_formula_sum            'C24 H23 N3 O'
_chemical_formula_weight         369.45

loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
N N 0.0061 0.0033 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'

_symmetry_cell_setting           Orthorhombic
_symmetry_space_group_name_H-M   Pbca

loop_
_symmetry_equiv_pos_as_xyz
'x, y, z'
'-x+1/2, -y, z+1/2'
'x+1/2, -y+1/2, -z'
'-x, y+1/2, -z+1/2'
'-x, -y, -z'
'x-1/2, y, -z-1/2'
'-x-1/2, y-1/2, z'
'x, -y-1/2, z-1/2'

_cell_length_a                   13.3996(18)
_cell_length_b                   12.191(2)
_cell_length_c                   22.958(3)
_cell_angle_alpha                90.00
_cell_angle_beta                 90.00
_cell_angle_gamma                90.00
_cell_volume                     3750.3(9)
_cell_formula_units_Z            8
_cell_measurement_temperature    113(2)
_cell_measurement_reflns_used    10997
_cell_measurement_theta_min      3.0
_cell_measurement_theta_max      27.5

_exptl_crystal_description       Prism
_exptl_crystal_colour            Colorless
_exptl_crystal_size_max          0.20
_exptl_crystal_size_mid          0.18
_exptl_crystal_size_min          0.12
_exptl_crystal_density_meas      ?
_exptl_crystal_density_diffrn    1.309
_exptl_crystal_density_method    'not measured'
_exptl_crystal_F_000             1568
_exptl_absorpt_coefficient_mu    0.081
_exptl_absorpt_correction_type   MULTI-SCAN
_exptl_absorpt_correction_T_min  0.9839
_exptl_absorpt_correction_T_max  0.9903
_exptl_absorpt_process_details   'REQAB (Rigaku, 1998)'

_exptl_special_details           
; 
 ? 
;

_diffrn_ambient_temperature      113(2)
_diffrn_radiation_wavelength     0.71073
_diffrn_radiation_type           MoK\a
_diffrn_radiation_source         'rotating anode'
_diffrn_radiation_monochromator  multilayer
_diffrn_measurement_device_type  'Rigaku XtaLAB P200'
_diffrn_measurement_method       'ω and φ scans'
_diffrn_detector_area_resol_mean 5.814
_diffrn_standards_number         0
_diffrn_standards_interval_count 0
_diffrn_standards_interval_time  0
_diffrn_standards_decay_%        0
_diffrn_reflns_number            45028
_diffrn_reflns_av_R_equivalents  0.0237
_diffrn_reflns_av_sigmaI/netI    0.0100
_diffrn_reflns_limit_h_min       -17
_diffrn_reflns_limit_h_max       17
_diffrn_reflns_limit_k_min       -15
_diffrn_reflns_limit_k_max       15
_diffrn_reflns_limit_l_min       -29
_diffrn_reflns_limit_l_max       29
_diffrn_reflns_theta_min         3.04
_diffrn_reflns_theta_max         27.62
_reflns_number_total             4327
_reflns_number_gt                3877
_reflns_threshold_expression     >2sigma(I)

_computing_data_collection       'CrystalClear-SM Expert 2.1 b42 (Rigaku, 2015)'
_computing_cell_refinement       'CrystalClear-SM Expert 2.1 b42'
_computing_data_reduction        'CrystalClear-SM Expert 2.1 b42'
_computing_structure_solution    'SHELXS-97 (Sheldrick, 1990)'
_computing_structure_refinement  'SHELXL-97 (Sheldrick, 1997)'
_computing_molecular_graphics    'CrystalStructure 4.1'
_computing_publication_material  'CrystalStructure 4.1 (Rigaku, 2014)'

_refine_special_details          
; 
 Refinement of F² against ALL reflections.  The weighted R-factor wR and 
 goodness of fit S are based on F², conventional R-factors R are based 
 on F, with F set to zero for negative F². The threshold expression of 
 F² > 2sigma(F²) is used only for calculating R-factors(gt) etc. and is 
 not relevant to the choice of reflections for refinement.  R-factors based 
 on F² are statistically about twice as large as those based on F, and R- 
 factors based on ALL data will be even larger. 
;

_refine_ls_structure_factor_coef Fsqd
_refine_ls_matrix_type           full
_refine_ls_weighting_scheme      calc
_refine_ls_weighting_details     
'calc w=1/[σ²(Fo²)+(0.0481P)²+1.3751P] where P=(Fo²+2Fc²)/3'
_atom_sites_solution_primary     direct
_atom_sites_solution_secondary   difmap
_atom_sites_solution_hydrogens   geom
_refine_ls_hydrogen_treatment    CONSTR
_refine_ls_extinction_method     none
_refine_ls_extinction_coef       ?
_refine_ls_number_reflns         4327
_refine_ls_number_parameters     254
_refine_ls_number_restraints     0
_refine_ls_R_factor_all          0.0377
_refine_ls_R_factor_gt           0.0343
_refine_ls_wR_factor_ref         0.0934
_refine_ls_wR_factor_gt          0.0915
_refine_ls_goodness_of_fit_ref   1.069
_refine_ls_restrained_S_all      1.069
_refine_ls_shift/su_max          0.001
_refine_ls_shift/su_mean         0.000

loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_symmetry_multiplicity
_atom_site_calc_flag
_atom_site_refinement_flags
_atom_site_disorder_assembly
_atom_site_disorder_group
O1 O 0.31561(6) -0.03430(6) 0.48531(3) 0.02228(17) Uani 1 1 d . . .
N1 N 0.21819(6) 0.05431(7) 0.42065(4) 0.01382(17) Uani 1 1 d . . .
N2 N 0.16685(6) 0.14973(7) 0.40832(3) 0.01343(17) Uani 1 1 d . . .
N3 N 0.19865(6) -0.01193(7) 0.32284(3) 0.01276(17) Uani 1 1 d . . .
C1 C 0.28701(8) 0.15678(9) 0.50404(4) 0.0192(2) Uani 1 1 d . . .
H1A H 0.3319 0.1451 0.5372 0.029 Uiso 1 1 calc R . .
H1B H 0.2214 0.1802 0.5183 0.029 Uiso 1 1 calc R . .
H1C H 0.3148 0.2136 0.4786 0.029 Uiso 1 1 calc R . .
C2 C 0.27619(7) 0.05169(8) 0.47047(4) 0.0154(2) Uani 1 1 d . . .
C3 C 0.20684(7) -0.04397(8) 0.38382(4) 0.01336(19) Uani 1 1 d . . .
H3 H 0.2687 -0.0891 0.3881 0.016 Uiso 1 1 calc R . .
C4 C 0.11872(7) -0.11479(8) 0.40213(4) 0.01429(19) Uani 1 1 d . . .
C5 C 0.06851(7) -0.09959(8) 0.45458(4) 0.0166(2) Uani 1 1 d . . .
H5 H 0.0858 -0.0397 0.4791 0.020 Uiso 1 1 calc R . .
C6 C -0.00687(8) -0.17162(9) 0.47140(5) 0.0199(2) Uani 1 1 d . . .
H6 H -0.0404 -0.1608 0.5074 0.024 Uiso 1 1 calc R . .
C7 C -0.03339(8) -0.25923(9) 0.43594(5) 0.0219(2) Uani 1 1 d . . .
H7 H -0.0844 -0.3086 0.4476 0.026 Uiso 1 1 calc R . .
C8 C 0.01573(9) -0.27378(9) 0.38309(5) 0.0225(2) Uani 1 1 d . . .
H8 H -0.0024 -0.3329 0.3583 0.027 Uiso 1 1 calc R . .
C9 C 0.09124(8) -0.20225(8) 0.36646(4) 0.0185(2) Uani 1 1 d . . .
H9 H 0.1245 -0.2131 0.3304 0.022 Uiso 1 1 calc R . .
C10 C 0.29369(7) 0.03842(8) 0.30292(4) 0.0156(2) Uani 1 1 d . . .
H10A H 0.3498 -0.0103 0.3138 0.019 Uiso 1 1 calc R . .
H10B H 0.3033 0.1092 0.3233 0.019 Uiso 1 1 calc R . .
C11 C 0.29636(7) 0.05808(8) 0.23798(4) 0.0152(2) Uani 1 1 d . . .
C12 C 0.33037(8) -0.02347(9) 0.20030(5) 0.0195(2) Uani 1 1 d . . .
H12 H 0.3505 -0.0924 0.2156 0.023 Uiso 1 1 calc R . .
C13 C 0.33509(8) -0.00488(10) 0.14050(5) 0.0255(2) Uani 1 1 d . . .
H13 H 0.3592 -0.0607 0.1153 0.031 Uiso 1 1 calc R . .
C14 C 0.30468(9) 0.09507(11) 0.11765(5) 0.0270(3) Uani 1 1 d . . .
H14 H 0.3070 0.1073 0.0768 0.032 Uiso 1 1 calc R . .
C15 C 0.27098(9) 0.17696(10) 0.15459(5) 0.0253(2) Uani 1 1 d . . .
H15 H 0.2502 0.2455 0.1391 0.030 Uiso 1 1 calc R . .
C16 C 0.26756(8) 0.15870(9) 0.21443(5) 0.0196(2) Uani 1 1 d . . .
H16 H 0.2453 0.2156 0.2396 0.023 Uiso 1 1 calc R . .
C17 C 0.11303(7) 0.06243(8) 0.31650(4) 0.01314(18) Uani 1 1 d . . .
H17A H 0.0505 0.0202 0.3212 0.016 Uiso 1 1 calc R . .
H17B H 0.1133 0.0941 0.2768 0.016 Uiso 1 1 calc R . .
C18 C 0.11539(7) 0.15439(8) 0.36079(4) 0.01289(18) Uani 1 1 d . . .
C19 C 0.05516(7) 0.25521(8) 0.35186(4) 0.01346(19) Uani 1 1 d . . .
C20 C 0.00489(8) 0.27530(8) 0.29952(4) 0.0179(2) Uani 1 1 d . . .
H20 H 0.0118 0.2254 0.2680 0.021 Uiso 1 1 calc R . .
C21 C -0.05514(8) 0.36777(9) 0.29316(5) 0.0202(2) Uani 1 1 d . . .
H21 H -0.0889 0.3804 0.2574 0.024 Uiso 1 1 calc R . .
C22 C -0.06591(8) 0.44141(8) 0.33866(5) 0.0193(2) Uani 1 1 d . . .
H22 H -0.1077 0.5038 0.3344 0.023 Uiso 1 1 calc R . .
C23 C -0.01510(8) 0.42357(8) 0.39074(4) 0.0180(2) Uani 1 1 d . . .
H23 H -0.0213 0.4746 0.4218 0.022 Uiso 1 1 calc R . .
C24 C 0.04457(7) 0.33134(8) 0.39726(4) 0.01549(19) Uani 1 1 d . . .
H24 H 0.0787 0.3196 0.4330 0.019 Uiso 1 1 calc R . .


_geom_special_details            
; 
 All esds (except the esd in the dihedral angle between two l.s. planes) 
 are estimated using the full covariance matrix.  The cell esds are taken 
 into account individually in the estimation of esds in distances, angles 
 and torsion angles; correlations between esds in cell parameters are only 
 used when they are defined by crystal symmetry.  An approximate (isotropic) 
 treatment of cell esds is used for estimating esds involving l.s. planes. 
;

loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
_geom_bond_site_symmetry_2
_geom_bond_publ_flag
O1 C2 1.2223(13) . ?
N1 N2 1.3808(11) . ?
N1 C2 1.3833(12) . ?
N1 C3 1.4743(12) . ?
N2 C18 1.2920(12) . ?
N3 C3 1.4576(12) . ?
N3 C17 1.4694(12) . ?
N3 C10 1.4858(12) . ?
C1 C2 1.5020(14) . ?
C1 H1A 0.9800 . ?
C1 H1B 0.9800 . ?
C1 H1C 0.9800 . ?
C3 C4 1.5219(13) . ?
C3 H3 1.0000 . ?
C4 C5 1.3917(13) . ?
C4 C9 1.3939(14) . ?
C5 C6 1.3930(14) . ?
C5 H5 0.9500 . ?
C6 C7 1.3893(16) . ?
C6 H6 0.9500 . ?
C7 C8 1.3916(16) . ?
C7 H7 0.9500 . ?
C8 C9 1.3892(15) . ?
C8 H8 0.9500 . ?
C9 H9 0.9500 . ?
C10 C11 1.5105(13) . ?
C10 H10A 0.9900 . ?
C10 H10B 0.9900 . ?
C11 C12 1.3944(14) . ?
C11 C16 1.3950(14) . ?
C12 C13 1.3927(15) . ?
C12 H12 0.9500 . ?
C13 C14 1.3879(18) . ?
C13 H13 0.9500 . ?
C14 C15 1.3855(17) . ?
C14 H14 0.9500 . ?
C15 C16 1.3925(15) . ?
C15 H15 0.9500 . ?
C16 H16 0.9500 . ?
C17 C18 1.5139(13) . ?
C17 H17A 0.9900 . ?
C17 H17B 0.9900 . ?
C18 C19 1.4846(13) . ?
C19 C20 1.3993(13) . ?
C19 C24 1.4029(14) . ?
C20 C21 1.3926(14) . ?
C20 H20 0.9500 . ?
C21 C22 1.3849(15) . ?
C21 H21 0.9500 . ?
C22 C23 1.3931(15) . ?
C22 H22 0.9500 . ?
C23 C24 1.3877(14) . ?
C23 H23 0.9500 . ?
C24 H24 0.9500 . ?

loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
_geom_angle_site_symmetry_1
_geom_angle_site_symmetry_3
_geom_angle_publ_flag
N2 N1 C2 117.96(8) . . ?
N2 N1 C3 121.05(8) . . ?
C2 N1 C3 120.89(8) . . ?
C18 N2 N1 118.43(8) . . ?
C3 N3 C17 108.61(7) . . ?
C3 N3 C10 109.99(7) . . ?
C17 N3 C10 112.58(7) . . ?
C2 C1 H1A 109.5 . . ?
C2 C1 H1B 109.5 . . ?
H1A C1 H1B 109.5 . . ?
C2 C1 H1C 109.5 . . ?
H1A C1 H1C 109.5 . . ?
H1B C1 H1C 109.5 . . ?
O1 C2 N1 119.54(9) . . ?
O1 C2 C1 123.16(9) . . ?
N1 C2 C1 117.30(8) . . ?
N3 C3 N1 109.92(8) . . ?
N3 C3 C4 111.03(8) . . ?
N1 C3 C4 112.50(8) . . ?
N3 C3 H3 107.7 . . ?
N1 C3 H3 107.7 . . ?
C4 C3 H3 107.7 . . ?
C5 C4 C9 118.84(9) . . ?
C5 C4 C3 122.58(9) . . ?
C9 C4 C3 118.47(9) . . ?
C4 C5 C6 120.43(9) . . ?
C4 C5 H5 119.8 . . ?
C6 C5 H5 119.8 . . ?
C7 C6 C5 120.50(10) . . ?
C7 C6 H6 119.7 . . ?
C5 C6 H6 119.7 . . ?
C6 C7 C8 119.21(10) . . ?
C6 C7 H7 120.4 . . ?
C8 C7 H7 120.4 . . ?
C9 C8 C7 120.27(10) . . ?
C9 C8 H8 119.9 . . ?
C7 C8 H8 119.9 . . ?
C8 C9 C4 120.74(10) . . ?
C8 C9 H9 119.6 . . ?
C4 C9 H9 119.6 . . ?
N3 C10 C11 112.93(8) . . ?
N3 C10 H10A 109.0 . . ?
C11 C10 H10A 109.0 . . ?
N3 C10 H10B 109.0 . . ?
C11 C10 H10B 109.0 . . ?
H10A C10 H10B 107.8 . . ?
C12 C11 C16 118.48(9) . . ?
C12 C11 C10 120.47(9) . . ?
C16 C11 C10 121.03(9) . . ?
C13 C12 C11 120.69(10) . . ?
C13 C12 H12 119.7 . . ?
C11 C12 H12 119.7 . . ?
C14 C13 C12 120.14(10) . . ?
C14 C13 H13 119.9 . . ?
C12 C13 H13 119.9 . . ?
C15 C14 C13 119.80(10) . . ?
C15 C14 H14 120.1 . . ?
C13 C14 H14 120.1 . . ?
C14 C15 C16 119.96(11) . . ?
C14 C15 H15 120.0 . . ?
C16 C15 H15 120.0 . . ?
C15 C16 C11 120.92(10) . . ?
C15 C16 H16 119.5 . . ?
C11 C16 H16 119.5 . . ?
N3 C17 C18 111.97(8) . . ?
N3 C17 H17A 109.2 . . ?
C18 C17 H17A 109.2 . . ?
N3 C17 H17B 109.2 . . ?
C18 C17 H17B 109.2 . . ?
H17A C17 H17B 107.9 . . ?
N2 C18 C19 116.30(8) . . ?
N2 C18 C17 123.08(8) . . ?
C19 C18 C17 120.60(8) . . ?
C20 C19 C24 118.26(9) . . ?
C20 C19 C18 121.68(9) . . ?
C24 C19 C18 120.01(9) . . ?
C21 C20 C19 120.65(9) . . ?
C21 C20 H20 119.7 . . ?
C19 C20 H20 119.7 . . ?
C22 C21 C20 120.39(10) . . ?
C22 C21 H21 119.8 . . ?
C20 C21 H21 119.8 . . ?
C21 C22 C23 119.68(9) . . ?
C21 C22 H22 120.2 . . ?
C23 C22 H22 120.2 . . ?
C24 C23 C22 120.05(9) . . ?
C24 C23 H23 120.0 . . ?
C22 C23 H23 120.0 . . ?
C23 C24 C19 120.94(9) . . ?
C23 C24 H24 119.5 . . ?
C19 C24 H24 119.5 . . ?

loop_
_geom_torsion_atom_site_label_1
_geom_torsion_atom_site_label_2
_geom_torsion_atom_site_label_3
_geom_torsion_atom_site_label_4
_geom_torsion
_geom_torsion_site_symmetry_1
_geom_torsion_site_symmetry_2
_geom_torsion_site_symmetry_3
_geom_torsion_site_symmetry_4
_geom_torsion_publ_flag
C2 N1 N2 C18 177.51(8) . . . . ?
C3 N1 N2 C18 -6.11(13) . . . . ?
N2 N1 C2 O1 173.71(9) . . . . ?
C3 N1 C2 O1 -2.68(14) . . . . ?
N2 N1 C2 C1 -6.07(13) . . . . ?
C3 N1 C2 C1 177.54(8) . . . . ?
C17 N3 C3 N1 -57.95(9) . . . . ?
C10 N3 C3 N1 65.66(9) . . . . ?
C17 N3 C3 C4 67.18(9) . . . . ?
C10 N3 C3 C4 -169.21(8) . . . . ?
N2 N1 C3 N3 37.86(11) . . . . ?
C2 N1 C3 N3 -145.86(8) . . . . ?
N2 N1 C3 C4 -86.42(10) . . . . ?
C2 N1 C3 C4 89.85(10) . . . . ?
N3 C3 C4 C5 -136.00(9) . . . . ?
N1 C3 C4 C5 -12.33(13) . . . . ?
N3 C3 C4 C9 47.90(11) . . . . ?
N1 C3 C4 C9 171.57(8) . . . . ?
C9 C4 C5 C6 0.92(14) . . . . ?
C3 C4 C5 C6 -175.17(9) . . . . ?
C4 C5 C6 C7 -0.38(15) . . . . ?
C5 C6 C7 C8 -0.50(16) . . . . ?
C6 C7 C8 C9 0.83(16) . . . . ?
C7 C8 C9 C4 -0.28(16) . . . . ?
C5 C4 C9 C8 -0.60(15) . . . . ?
C3 C4 C9 C8 175.65(9) . . . . ?
C3 N3 C10 C11 171.32(8) . . . . ?
C17 N3 C10 C11 -67.41(10) . . . . ?
N3 C10 C11 C12 -88.48(11) . . . . ?
N3 C10 C11 C16 93.24(11) . . . . ?
C16 C11 C12 C13 -0.22(15) . . . . ?
C10 C11 C12 C13 -178.55(9) . . . . ?
C11 C12 C13 C14 -0.79(16) . . . . ?
C12 C13 C14 C15 0.96(17) . . . . ?
C13 C14 C15 C16 -0.12(17) . . . . ?
C14 C15 C16 C11 -0.91(17) . . . . ?
C12 C11 C16 C15 1.07(15) . . . . ?
C10 C11 C16 C15 179.39(9) . . . . ?
C3 N3 C17 C18 49.78(10) . . . . ?
C10 N3 C17 C18 -72.28(10) . . . . ?
N1 N2 C18 C19 175.27(8) . . . . ?
N1 N2 C18 C17 -3.27(13) . . . . ?
N3 C17 C18 N2 -19.70(12) . . . . ?
N3 C17 C18 C19 161.83(8) . . . . ?
N2 C18 C19 C20 173.02(9) . . . . ?
C17 C18 C19 C20 -8.40(13) . . . . ?
N2 C18 C19 C24 -9.32(13) . . . . ?
C17 C18 C19 C24 169.26(8) . . . . ?
C24 C19 C20 C21 -0.89(14) . . . . ?
C18 C19 C20 C21 176.81(9) . . . . ?
C19 C20 C21 C22 0.05(16) . . . . ?
C20 C21 C22 C23 0.99(16) . . . . ?
C21 C22 C23 C24 -1.15(15) . . . . ?
C22 C23 C24 C19 0.29(15) . . . . ?
C20 C19 C24 C23 0.73(14) . . . . ?
C18 C19 C24 C23 -177.02(9) . . . . ?

_diffrn_measured_fraction_theta_max 0.994
_diffrn_reflns_theta_full        27.62
_diffrn_measured_fraction_theta_full 0.994
_refine_diff_density_max         0.337
_refine_diff_density_min         -0.251
_refine_diff_density_rms         0.041
