==> chlorpromazine_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.7670976555830445e-09 1.4751820879783803e-10 5.105674107524594e-10 11.97884430663547 -6.0 -8.752739449299728 -9.831154369568223 -9.291946909433975 5e-06 8.835488277915223e-09 7.3759104398919e-10 2.5528370537622965e-09 11.978844306635473 -5.301029995663981 -8.05376944496371 -9.132184365232204 -8.592976905097956 1e-05 1.7670976555830447e-08 1.47518208797838e-09 5.105674107524594e-09 11.978844306635473 -5.0 -7.752739449299728 -8.831154369568223 -8.291946909433975 5e-05 8.835488277915224e-08 7.375910439891901e-09 2.5528370537622913e-08 11.978844306635473 -4.301029995663981 -7.053769444963709 -8.132184365232204 -7.592976905097957 0.0001 1.7670976555830448e-07 1.4751820879783801e-08 5.105674107524583e-08 11.978844306635473 -4.0 -6.752739449299728 -7.831154369568223 -7.2919469094339755 0.001 1.7670976555830444e-06 1.47518208797838e-07 5.105674107524583e-07 11.97884430663547 -3.0 -5.752739449299728 -6.831154369568223 -6.2919469094339755 0.01 1.7670976555830445e-05 1.4751820879783798e-06 5.105674107524584e-06 11.978844306635473 -2.0 -4.752739449299728 -5.831154369568223 -5.2919469094339755 0.1 0.00017670976555830449 1.4751820879783801e-05 5.1056741075245834e-05 11.978844306635473 -1.0 -3.7527394492997277 -4.831154369568223 -4.2919469094339755 1.0 0.0017670976555830443 0.00014751820879783798 0.0005105674107524584 11.978844306635471 0.0 -2.7527394492997277 -3.8311543695682233 -3.2919469094339755 10.0 0.017670976555830442 0.0014751820879783802 0.005105674107524583 11.978844306635468 1.0 -1.752739449299728 -2.831154369568223 -2.2919469094339755 25.0 0.04417744138957611 0.0036879552199459505 0.012764185268811462 11.97884430663547 1.3979400086720377 -1.3547994406276902 -2.4332143608961854 -1.8940069007619378 50.0 0.08835488277915222 0.007375910439891901 0.025528370537622927 11.97884430663547 1.6989700043360187 -1.053769444963709 -2.132184365232204 -1.5929769050979565 75.0 0.1649783670929227 0.022131441800028785 0.06042523586698526 7.454478952776955 1.8750612633917 -0.7825729992291892 -1.6549902921098134 -1.2187816456695013 100.0 0.16869566589275978 0.025886774307962403 0.06608317962762766 6.516673877010292 2.0 -0.7728960751052306 -1.5869220626408373 -1.179909068873034 250.0 0.23964615384938903 0.048831288383473885 0.10817684802493492 4.907635284316872 2.3979400086720375 -0.6204295367343293 -1.3113018169722417 -0.9658656768532855 500.0 0.32133758012276475 0.08869057215780062 0.16881828644104613 3.6231312111847966 2.6989700043360187 -0.49303848115388044 -1.0521225433865045 -0.7725805122701924 1000.0 0.510495633523501 0.17486780060439278 0.29877959878880744 2.91932323594786 3.0 -0.2920079682582833 -0.757290152255069 -0.5246490602566762 2500.0 0.7194544836224736 0.2932882353734447 0.4593555659107094 2.453062880979151 3.3979400086720375 -0.14299667655278225 -0.5327053574588199 -0.33785101700580106 5000.0 0.7194544836224736 0.2932882353734447 0.4593555659107094 2.453062880979151 3.6989700043360187 -0.14299667655278225 -0.5327053574588199 -0.33785101700580106 10000.0 0.7194544836224736 0.2932882353734447 0.4593555659107094 2.453062880979151 4.0 -0.14299667655278225 -0.5327053574588199 -0.33785101700580106 ==> chlorpromazine_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 6.271375505995848e-10 1.4630445167111264e-10 3.0290760218726225e-10 4.286524049243344 -6.0 -9.202637194552427 -9.834742459200827 -9.518689826876628 5e-06 3.1356877529979247e-09 7.315222583555634e-10 1.514538010936311e-09 4.286524049243344 -5.301029995663981 -8.503667190216408 -9.135772454864808 -8.819719822540609 1e-05 6.271375505995849e-09 1.4630445167111268e-09 3.0290760218726224e-09 4.286524049243344 -5.0 -8.202637194552427 -8.834742459200827 -8.518689826876628 5e-05 3.135687752997924e-08 7.315222583555633e-09 1.514538010936314e-08 4.286524049243343 -4.301029995663981 -7.503667190216408 -8.135772454864808 -7.819719822540608 0.0001 6.271375505995848e-08 1.4630445167111266e-08 3.029076021872623e-08 4.286524049243343 -4.0 -7.202637194552427 -7.834742459200828 -7.518689826876628 0.001 6.271375505995848e-07 1.4630445167111263e-07 3.0290760218726224e-07 4.286524049243344 -3.0 -6.202637194552427 -6.834742459200828 -6.518689826876628 0.01 6.271375505995849e-06 1.4630445167111266e-06 3.0290760218726223e-06 4.286524049243344 -2.0 -5.202637194552427 -5.834742459200828 -5.518689826876628 0.1 6.27137550599585e-05 1.4630445167111265e-05 3.0290760218726223e-05 4.286524049243344 -1.0 -4.202637194552427 -4.834742459200828 -4.518689826876628 1.0 0.0006271375505995849 0.00014630445167111266 0.00030290760218726256 4.286524049243344 0.0 -3.202637194552427 -3.834742459200828 -3.5186898268766273 10.0 0.006271375505995847 0.0014630445167111263 0.0030290760218726256 4.286524049243343 1.0 -2.202637194552427 -2.834742459200828 -2.5186898268766273 25.0 0.01567843876498962 0.0036576112917778157 0.00757269005468157 4.286524049243344 1.3979400086720377 -1.8046971858803893 -2.43680245052879 -2.1207498182045894 50.0 0.03135687752997924 0.0073152225835556315 0.015145380109363126 4.286524049243344 1.6989700043360187 -1.503667190216408 -2.135772454864809 -1.8197198225406086 75.0 0.09334684244960152 0.02194935169837924 0.04526480613964342 4.2528291373860645 1.8750612633917 -1.029900367912086 -1.6585783026644332 -1.3442393352882596 100.0 0.10857720046231585 0.025673789197600994 0.052797615062947306 4.229106955215691 2.0 -0.9642613603174939 -1.5905100290237733 -1.2773856946706337 250.0 0.19414454021921612 0.04842956528522442 0.09696564177746882 4.008802042219621 2.3979400086720375 -0.7118748182830512 -1.3148894292618556 -1.0133821237724534 500.0 0.31739682215278375 0.08796112168894182 0.1670885408909433 3.6083762468968814 2.6989700043360187 -0.4983974258118554 -1.055709241109658 -0.7770533334607568 1000.0 0.5135919200609632 0.173431158142539 0.2984507354804527 2.9613589943212744 3.0 -0.2893818173000684 -0.7608728757539533 -0.5251273465270109 2500.0 0.7238380599427928 0.2908889277374022 0.4588643341035349 2.48836580193328 3.3979400086720375 -0.14035858510103105 -0.5362728092241125 -0.33831569716257176 5000.0 0.7238380599427928 0.2908889277374022 0.4588643341035349 2.48836580193328 3.6989700043360187 -0.14035858510103105 -0.5362728092241125 -0.33831569716257176 10000.0 0.7238380599427928 0.2908889277374022 0.4588643341035349 2.48836580193328 4.0 -0.14035858510103105 -0.5362728092241125 -0.33831569716257176 ==> chlorpromazine_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 6.255336330870653e-09 1.0502585032070854e-10 8.105381034792332e-10 59.559968443666605 -6.0 -8.203749334617346 -9.978703793597667 -9.091226564107506 5e-06 3.1276681654353264e-08 5.251292516035428e-10 4.0526905173961655e-09 59.5599684436666 -5.301029995663981 -7.504779330281327 -9.279733789261648 -8.392256559771488 1e-05 6.255336330870653e-08 1.0502585032070855e-09 8.105381034792333e-09 59.5599684436666 -5.0 -7.203749334617346 -8.978703793597667 -8.091226564107506 5e-05 3.127668165435327e-07 5.251292516035429e-09 4.052690517396166e-08 59.55996844366659 -4.301029995663981 -6.504779330281327 -8.279733789261648 -7.3922565597714875 0.0001 6.255336330870654e-07 1.0502585032070858e-08 8.105381034792333e-08 59.55996844366659 -4.0 -6.203749334617346 -7.978703793597667 -7.091226564107506 0.001 6.255336330870652e-06 1.0502585032070855e-07 8.105381034792332e-07 59.55996844366659 -3.0 -5.203749334617346 -6.978703793597667 -6.091226564107506 0.01 6.255336330870653e-05 1.0502585032070856e-06 8.105381034792332e-06 59.5599684436666 -2.0 -4.203749334617346 -5.978703793597667 -5.091226564107506 0.1 0.0006255336330870654 1.0502585032070857e-05 8.105381034792332e-05 59.5599684436666 -1.0 -3.2037493346173456 -4.978703793597667 -4.091226564107506 1.0 0.006255336330870651 0.00010502585032070854 0.0008105381034792324 59.55996844366659 0.0 -2.203749334617346 -3.9787037935976675 -3.0912265641075067 10.0 0.06255336330870652 0.0010502585032070857 0.008105381034792324 59.55996844366658 1.0 -1.2037493346173458 -2.9787037935976675 -2.0912265641075067 25.0 0.15638340827176633 0.0026256462580177137 0.020263452586980826 59.559968443666605 1.3979400086720377 -0.8058093259453081 -2.5807637849256295 -1.6932865554354688 50.0 0.31276681654353267 0.005251292516035427 0.04052690517396163 59.559968443666605 1.6989700043360187 -0.5047793302813269 -2.2797337892616487 -1.3922565597714878 75.0 0.7307975279619044 0.01572879617586227 0.10721271082822595 46.46239418394913 1.8750612633917 -0.1362029303867135 -1.803304515405119 -0.9697537228959163 100.0 0.7334357908223961 0.018380717355813977 0.11610803576731615 39.90245737554982 2.0 -0.13463790078746338 -1.7356375431353217 -0.9351377219613926 250.0 0.7677225141013421 0.03445165580843754 0.16263244391021053 22.284052713464053 2.3979400086720375 -0.11479572315945906 -1.462789900282149 -0.788792811720804 500.0 0.8079662740631535 0.06185372415190276 0.2235525062260385 13.062532372002675 2.6989700043360187 -0.0926067670644742 -1.208634146803983 -0.6506204569342285 1000.0 0.8967090634791184 0.11905197746188252 0.32673381706701526 7.532080378641525 3.0 -0.04734844059114581 -0.9242633865367045 -0.4858059135639251 2500.0 0.9996321133946448 0.19370622959266948 0.44003973418934395 5.160557383707779 3.3979400086720375 -0.00015980051870970787 -0.712856412145028 -0.35650810633186886 5000.0 0.9996321133946448 0.19370622959266948 0.44003973418934395 5.160557383707779 3.6989700043360187 -0.00015980051870970787 -0.712856412145028 -0.35650810633186886 10000.0 0.9996321133946448 0.19370622959266948 0.44003973418934395 5.160557383707779 4.0 -0.00015980051870970787 -0.712856412145028 -0.35650810633186886 ==> chlorpromazine_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 6.570549211573797e-10 1.0436914328133463e-10 2.6187069177359323e-10 6.2954902234489 -6.0 -9.182398327611137 -9.981427881443317 -9.581913104527228 5e-06 3.2852746057868993e-09 5.218457164066731e-10 1.3093534588679658e-09 6.295490223448903 -5.301029995663981 -8.483428323275119 -9.282457877107298 -8.88294310019121 1e-05 6.570549211573799e-09 1.0436914328133462e-09 2.618706917735932e-09 6.295490223448903 -5.0 -8.182398327611137 -8.981427881443317 -8.581913104527228 5e-05 3.285274605786899e-08 5.218457164066731e-09 1.3093534588679686e-08 6.295490223448902 -4.301029995663981 -7.483428323275119 -8.282457877107298 -7.882943100191208 0.0001 6.570549211573798e-08 1.0436914328133462e-08 2.6187069177359375e-08 6.295490223448902 -4.0 -7.182398327611137 -7.981427881443317 -7.581913104527227 0.001 6.570549211573798e-07 1.0436914328133464e-07 2.618706917735938e-07 6.295490223448901 -3.0 -6.182398327611137 -6.981427881443317 -6.581913104527227 0.01 6.570549211573797e-06 1.0436914328133463e-06 2.6187069177359374e-06 6.2954902234489 -2.0 -5.182398327611137 -5.981427881443317 -5.581913104527227 0.1 6.570549211573798e-05 1.0436914328133466e-05 2.6187069177359376e-05 6.2954902234489 -1.0 -4.182398327611137 -4.981427881443317 -4.581913104527227 1.0 0.0006570549211573798 0.00010436914328133464 0.00026187069177359374 6.295490223448901 0.0 -3.182398327611137 -3.9814278814433166 -3.581913104527227 10.0 0.006570549211573798 0.0010436914328133462 0.0026187069177359378 6.295490223448902 1.0 -2.182398327611137 -2.9814278814433166 -2.581913104527227 25.0 0.016426373028934495 0.002609228582033366 0.006546767294339842 6.295490223448901 1.3979400086720377 -1.7844583189390995 -2.583487872771279 -2.1839730958551895 50.0 0.03285274605786899 0.005218457164066732 0.013093534588679692 6.295490223448901 1.6989700043360187 -1.4834283232751182 -2.282457877107298 -1.882943100191208 75.0 0.09794436822280554 0.015663523838631208 0.039168277298313604 6.25302257856203 1.8750612633917 -1.0090205307777225 -1.8051105276220238 -1.407065529199873 100.0 0.1139305047207958 0.018324982099159427 0.045692170659280155 6.2172232477117575 2.0 -0.9433599786585202 -1.7369564409291307 -1.3401582097938254 250.0 0.20649982716990317 0.034621392732343985 0.08455360202623172 5.964515314746047 2.3979400086720375 -0.6850803074903346 -1.4606554655245858 -1.0728678865074601 500.0 0.35142533017083943 0.06311624611227792 0.1489316877939387 5.56790607517574 2.6989700043360187 -0.4541669384669235 -1.1998588390319043 -0.8270128887494139 1000.0 0.5923771693239754 0.1259003509126037 0.2730942941375805 4.705127229829455 3.0 -0.22740168787480547 -0.8999730594140196 -0.5636873736444126 2500.0 0.8321450253462037 0.21603889531524578 0.42399963681337166 3.8518296630425306 3.3979400086720375 -0.07980097873462837 -0.6654680520894165 -0.3726345154120224 5000.0 0.8321450253462037 0.21603889531524578 0.42399963681337166 3.8518296630425306 3.6989700043360187 -0.07980097873462837 -0.6654680520894165 -0.3726345154120224 10000.0 0.8321450253462037 0.21603889531524578 0.42399963681337166 3.8518296630425306 4.0 -0.07980097873462837 -0.6654680520894165 -0.3726345154120224 ==> chlorpromazine_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.0439939974340054e-09 1.1901246977038937e-10 3.5248872898304556e-10 8.772139587122105 -6.0 -8.981301998353663 -9.9244075321474 -9.452854765250532 5e-06 5.2199699871700285e-09 5.95062348851947e-10 1.7624436449152276e-09 8.772139587122105 -5.301029995663981 -8.282331994017644 -9.225437527811382 -8.753884760914513 1e-05 1.0439939974340057e-08 1.190124697703894e-09 3.5248872898304556e-09 8.772139587122105 -5.0 -7.981301998353664 -8.9244075321474 -8.452854765250532 5e-05 5.2199699871700265e-08 5.950623488519471e-09 1.7624436449152276e-08 8.772139587122101 -4.301029995663981 -7.282331994017645 -8.225437527811382 -7.753884760914513 0.0001 1.0439939974340053e-07 1.1901246977038941e-08 3.5248872898304486e-08 8.772139587122101 -4.0 -6.981301998353664 -7.924407532147401 -7.452854765250533 0.001 1.0439939974340053e-06 1.1901246977038941e-07 3.5248872898304483e-07 8.772139587122101 -3.0 -5.981301998353664 -6.924407532147401 -6.452854765250533 0.01 1.0439939974340054e-05 1.1901246977038939e-06 3.5248872898304483e-06 8.772139587122103 -2.0 -4.981301998353664 -5.924407532147401 -5.452854765250533 0.1 0.00010439939974340055 1.1901246977038943e-05 3.5248872898304486e-05 8.772139587122101 -1.0 -3.9813019983536635 -4.924407532147401 -4.452854765250533 1.0 0.0010439939974340054 0.0001190124697703894 0.00035248872898304486 8.772139587122103 0.0 -2.981301998353664 -3.9244075321474012 -3.4528547652505326 10.0 0.010439939974340054 0.001190124697703894 0.003524887289830452 8.772139587122101 1.0 -1.9813019983536637 -2.924407532147401 -2.452854765250532 25.0 0.02609984993585013 0.0029753117442597346 0.008812218224576127 8.772139587122103 1.3979400086720377 -1.5833619896816262 -2.5264675234753633 -2.0549147565784947 50.0 0.05219969987170026 0.005950623488519469 0.01762443644915224 8.772139587122103 1.6989700043360187 -1.282331994017645 -2.2254375278113825 -1.7538847609145138 75.0 0.15529613968887473 0.01783475613863567 0.0526276427424085 8.707500034298459 1.8750612633917 -0.8088393397167545 -1.7487328245576952 -1.2787860821372248 100.0 0.1799910297607838 0.020848685633572964 0.061258276145723004 8.633207528005576 2.0 -0.7447491383548454 -1.6809213191112926 -1.212835228733069 250.0 0.315875479215553 0.03916751653791144 0.11122975346594935 8.064730857005127 2.3979400086720375 -0.5004840862021834 -1.407073964527545 -0.9537790253648641 500.0 0.4925191139395013 0.07061548702346064 0.18649256580143128 6.974661433346361 2.6989700043360187 -0.307576910511802 -1.1511000412820749 -0.7293384758969385 1000.0 0.7128526309072748 0.13712337363213015 0.3126479772084656 5.198622321090868 3.0 -0.14700024321810565 -0.86288851038737 -0.5049443768027378 2500.0 0.8992621592717256 0.22573461513676502 0.4505492175448308 3.9837140561136044 3.3979400086720375 -0.0461136812059617 -0.6464018391933817 -0.3462577601996717 5000.0 0.8992621592717256 0.22573461513676502 0.4505492175448308 3.9837140561136044 3.6989700043360187 -0.0461136812059617 -0.6464018391933817 -0.3462577601996717 10000.0 0.8992621592717256 0.22573461513676502 0.4505492175448308 3.9837140561136044 4.0 -0.0461136812059617 -0.6464018391933817 -0.3462577601996717 ==> diazepam_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.6116076531612243e-07 3.904691021719347e-08 7.932735930202663e-08 4.127362816153344 -6.0 -6.79274067891223 -7.4084133261583345 -7.100577002535282 5e-06 8.058038265806121e-07 1.9523455108596739e-07 3.966367965101331e-07 4.127362816153343 -5.301029995663981 -6.093770674576211 -6.709443321822316 -6.401606998199263 1e-05 1.6116076531612241e-06 3.9046910217193477e-07 7.932735930202663e-07 4.127362816153343 -5.0 -5.79274067891223 -6.4084133261583345 -6.100577002535282 5e-05 8.05803826580612e-06 1.9523455108596733e-06 3.966367965101331e-06 4.127362816153344 -4.301029995663981 -5.093770674576211 -5.709443321822316 -5.401606998199263 0.0001 1.611607653161224e-05 3.9046910217193465e-06 7.932735930202664e-06 4.127362816153344 -4.0 -4.79274067891223 -5.4084133261583345 -5.100577002535282 0.001 0.0001611607653161224 3.904691021719347e-05 7.932735930202663e-05 4.127362816153343 -3.0 -3.7927406789122298 -4.4084133261583345 -4.100577002535282 0.01 0.001611607653161224 0.00039046910217193476 0.0007932735930202655 4.127362816153343 -2.0 -2.7927406789122298 -3.4084133261583345 -3.100577002535282 0.1 0.016116076531612244 0.003904691021719348 0.007932735930202656 4.127362816153343 -1.0 -1.7927406789122295 -2.4084133261583345 -2.100577002535282 1.0 0.1611607653161224 0.03904691021719347 0.07932735930202656 4.127362816153343 0.0 -0.7927406789122297 -1.4084133261583347 -1.1005770025352821 10.0 2.1135899646843925 0.5314430543399459 1.0598361696291232 3.9770770309708507 1.0 0.32502073824710837 -0.2745432645572255 0.025238736844941392 25.0 3.0822217173910715 1.124137456825765 1.8614083062995985 2.7418548316096176 1.3979400086720377 0.4888638761656914 0.05081941896524325 0.2698416475654673 50.0 4.328856820503597 2.12545029169283 3.033277104360211 2.036677516017487 1.6989700043360187 0.6363732215041816 0.3274509524948855 0.4819120869995336 75.0 5.535641686387059 3.1438734612238455 4.171733091734979 1.7607711489228155 1.8750612633917 0.7431679711414221 0.4974650576605737 0.6203165144009979 100.0 6.787048053344502 4.179405382851668 5.325957676119944 1.62392671483655 2.0 0.8316809240741063 0.6211144977282103 0.7263977109011583 250.0 7.7028879064274065 4.968114796487628 6.1861806782220325 1.5504649594395878 2.3979400086720375 0.8866535779891733 0.6961916223748679 0.7914226001820206 500.0 7.7028879064274065 4.968114796487628 6.1861806782220325 1.5504649594395878 2.6989700043360187 0.8866535779891733 0.6961916223748679 0.7914226001820206 1000.0 7.7028879064274065 4.968114796487628 6.1861806782220325 1.5504649594395878 3.0 0.8866535779891733 0.6961916223748679 0.7914226001820206 2500.0 7.7028879064274065 4.968114796487628 6.1861806782220325 1.5504649594395878 3.3979400086720375 0.8866535779891733 0.6961916223748679 0.7914226001820206 5000.0 7.7028879064274065 4.968114796487628 6.1861806782220325 1.5504649594395878 3.6989700043360187 0.8866535779891733 0.6961916223748679 0.7914226001820206 10000.0 7.7028879064274065 4.968114796487628 6.1861806782220325 1.5504649594395878 4.0 0.8866535779891733 0.6961916223748679 0.7914226001820206 ==> diazepam_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 6.444638593752459e-08 3.951394681094799e-08 5.046316543869568e-08 1.6309782023512938 -6.0 -7.190801432250051 -7.403249589083209 -7.29702551066663 5e-06 3.22231929687623e-07 1.9756973405473998e-07 2.5231582719347834e-07 1.6309782023512938 -5.301029995663981 -6.491831427914033 -6.70427958474719 -6.598055506330612 1e-05 6.44463859375246e-07 3.9513946810947997e-07 5.046316543869568e-07 1.6309782023512938 -5.0 -6.190801432250051 -6.403249589083209 -6.29702551066663 5e-05 3.22231929687623e-06 1.9756973405473998e-06 2.5231582719347836e-06 1.6309782023512938 -4.301029995663981 -5.491831427914033 -5.70427958474719 -5.598055506330612 0.0001 6.44463859375246e-06 3.9513946810947996e-06 5.046316543869568e-06 1.6309782023512938 -4.0 -5.190801432250051 -5.403249589083209 -5.29702551066663 0.001 6.44463859375246e-05 3.951394681094799e-05 5.0463165438695676e-05 1.630978202351294 -3.0 -4.190801432250051 -4.403249589083209 -4.29702551066663 0.01 0.0006444638593752459 0.00039513946810947997 0.0005046316543869568 1.6309782023512935 -2.0 -3.1908014322500518 -3.4032495890832086 -3.2970255106666304 0.1 0.00644463859375246 0.003951394681094798 0.005046316543869568 1.6309782023512944 -1.0 -2.1908014322500518 -2.4032495890832086 -2.2970255106666304 1.0 0.0644463859375246 0.03951394681094799 0.05046316543869573 1.6309782023512938 0.0 -1.1908014322500515 -1.4032495890832086 -1.29702551066663 10.0 0.8722469176289049 0.5381130946305249 0.6851039980376896 1.6209360566254207 1.0 -0.05936055659939645 -0.269126439552493 -0.1642434980759447 25.0 1.8151539897772384 1.1396341069736882 1.4382668028427514 1.5927515495279456 1.3979400086720377 0.2589134745917846 0.05676543832876879 0.15783945646027667 50.0 3.3265456205411628 2.1597413992252474 2.6803877132038547 1.5402518198403183 1.6989700043360187 0.5219934837758846 0.3344017531819575 0.428197618478921 75.0 4.7652599644776155 3.203099154880636 3.9068657725860994 1.4877029195979399 1.8750612633917 0.6780865981660458 0.5055703828570746 0.5918284905115602 100.0 6.1306161930180325 4.271134842467863 5.117097656660169 1.4353600200259098 2.0 0.7875041279895834 0.6305432825987509 0.7090237052941671 250.0 7.180670003213769 5.090164045730353 6.045724793158649 1.4106952032787508 2.3979400086720375 0.8561649686327004 0.7067317789983367 0.7814483738155186 500.0 7.180670003213769 5.090164045730353 6.045724793158649 1.4106952032787508 2.6989700043360187 0.8561649686327004 0.7067317789983367 0.7814483738155186 1000.0 7.180670003213769 5.090164045730353 6.045724793158649 1.4106952032787508 3.0 0.8561649686327004 0.7067317789983367 0.7814483738155186 2500.0 7.180670003213769 5.090164045730353 6.045724793158649 1.4106952032787508 3.3979400086720375 0.8561649686327004 0.7067317789983367 0.7814483738155186 5000.0 7.180670003213769 5.090164045730353 6.045724793158649 1.4106952032787508 3.6989700043360187 0.8561649686327004 0.7067317789983367 0.7814483738155186 10000.0 7.180670003213769 5.090164045730353 6.045724793158649 1.4106952032787508 4.0 0.8561649686327004 0.7067317789983367 0.7814483738155186 ==> diazepam_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 2.6429946943594857e-07 1.90967580701748e-08 7.104409212519983e-08 13.840017685972041 -6.0 -6.577903708685433 -7.719040353785592 -7.148472031235512 5e-06 1.3214973471797433e-06 9.548379035087402e-08 3.552204606259991e-07 13.840017685972045 -5.301029995663981 -5.878933704349414 -7.020070349449573 -6.449502026899493 1e-05 2.6429946943594867e-06 1.9096758070174803e-07 7.104409212519983e-07 13.840017685972045 -5.0 -5.577903708685433 -6.719040353785592 -6.148472031235512 5e-05 1.3214973471797429e-05 9.548379035087402e-07 3.5522046062599913e-06 13.840017685972041 -4.301029995663981 -4.878933704349414 -6.020070349449573 -5.449502026899493 0.0001 2.6429946943594857e-05 1.9096758070174803e-06 7.1044092125199834e-06 13.840017685972041 -4.0 -4.577903708685433 -5.719040353785592 -5.148472031235512 0.001 0.0002642994694359486 1.9096758070174804e-05 7.104409212519969e-05 13.840017685972043 -3.0 -3.5779037086854335 -4.719040353785592 -4.148472031235513 0.01 0.002642994694359486 0.00019096758070174798 0.0007104409212519969 13.840017685972047 -2.0 -2.5779037086854335 -3.7190403537855916 -3.148472031235513 0.1 0.02642994694359486 0.0019096758070174802 0.007104409212519976 13.840017685972043 -1.0 -1.5779037086854335 -2.719040353785591 -2.1484720312355123 1.0 0.2642994694359486 0.019096758070174802 0.07104409212519976 13.840017685972045 0.0 -0.5779037086854334 -1.7190403537855914 -1.1484720312355123 10.0 3.384409343217984 0.25962440154297445 0.9373767920689206 13.035790638723064 1.0 0.5294828853212994 -0.5856544915425774 -0.02808580311063899 25.0 6.161998255810005 0.5479680362871585 1.8375467569128967 11.245178272735703 1.3979400086720377 0.7897215710513215 -0.26124477375827393 0.26423839864652376 50.0 8.932092468328664 1.032201831341186 3.0363995460936395 8.653435982304735 1.6989700043360187 0.9509532103999625 0.013764625263545535 0.482358917831754 75.0 10.458342896410306 1.5211392753619848 3.9885581523819775 6.8753355237123435 1.8750612633917 1.0194628768871685 0.1821689798334196 0.6008159283602941 100.0 11.532075001496004 2.0149135745374998 4.820387376871164 5.723359625557666 2.0 1.0619074582591745 0.30425642273200604 0.6830819404955903 250.0 12.126683852037244 2.3890775219122973 5.382526154719456 5.07588545822098 2.3979400086720375 1.083742055470116 0.3782302421703486 0.7309861488202323 500.0 12.126683852037244 2.3890775219122973 5.382526154719456 5.07588545822098 2.6989700043360187 1.083742055470116 0.3782302421703486 0.7309861488202323 1000.0 12.126683852037244 2.3890775219122973 5.382526154719456 5.07588545822098 3.0 1.083742055470116 0.3782302421703486 0.7309861488202323 2500.0 12.126683852037244 2.3890775219122973 5.382526154719456 5.07588545822098 3.3979400086720375 1.083742055470116 0.3782302421703486 0.7309861488202323 5000.0 12.126683852037244 2.3890775219122973 5.382526154719456 5.07588545822098 3.6989700043360187 1.083742055470116 0.3782302421703486 0.7309861488202323 10000.0 12.126683852037244 2.3890775219122973 5.382526154719456 5.07588545822098 4.0 1.083742055470116 0.3782302421703486 0.7309861488202323 ==> diazepam_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 6.155449620709013e-08 3.592041737514684e-08 4.7021943761137415e-08 1.7136353279034944 -6.0 -7.21074021882347 -7.444658625716591 -7.3276994222700305 5e-06 3.077724810354506e-07 1.7960208687573425e-07 2.3510971880568705e-07 1.7136353279034937 -5.301029995663981 -6.511770214487451 -6.745688621380572 -6.628729417934012 1e-05 6.155449620709012e-07 3.592041737514685e-07 4.7021943761137415e-07 1.7136353279034937 -5.0 -6.21074021882347 -6.444658625716591 -6.3276994222700305 5e-05 3.0777248103545068e-06 1.7960208687573427e-06 2.351097188056875e-06 1.713635327903494 -4.301029995663981 -5.51177021448745 -5.745688621380572 -5.628729417934011 0.0001 6.1554496207090136e-06 3.5920417375146854e-06 4.702194376113742e-06 1.713635327903494 -4.0 -5.21074021882347 -5.444658625716591 -5.3276994222700305 0.001 6.155449620709013e-05 3.592041737514685e-05 4.7021943761137513e-05 1.713635327903494 -3.0 -4.210740218823469 -4.444658625716591 -4.32769942227003 0.01 0.0006155449620709012 0.0003592041737514686 0.00047021943761137413 1.7136353279034933 -2.0 -3.2107402188234695 -3.444658625716591 -3.3276994222700305 0.1 0.006155449620709013 0.003592041737514685 0.0047021943761137415 1.713635327903494 -1.0 -2.2107402188234695 -2.444658625716591 -2.3276994222700305 1.0 0.06155449620709012 0.035920417375146854 0.04702194376113744 1.7136353279034935 0.0 -1.2107402188234695 -1.444658625716591 -1.3276994222700302 10.0 0.8336181590386185 0.49016180372037677 0.6392243584598675 1.7006999580778712 1.0 -0.07903283353066871 -0.3096605345359743 -0.1943466840333215 25.0 1.7401321884157006 1.042199311396788 1.346686514563144 1.669673131988085 1.3979400086720377 0.24058224053486474 0.017950781883252356 0.12926651120905855 50.0 3.210501766784483 1.988405090860072 2.5266139509805456 1.6146115203294922 1.6989700043360187 0.5065729132509686 0.2985048663808658 0.40253888981591723 75.0 4.617830994373376 2.968685291452607 3.7025514110421485 1.5555138187496544 1.8750612633917 0.6644380343511513 0.4725641607385961 0.5685010975448737 100.0 5.978827731918333 3.984431208179556 4.880801963139336 1.5005473603470734 2.0 0.7766160402649251 0.6003663330646654 0.6884911866647953 250.0 7.018787506086644 4.771024667092706 5.78677875200197 1.471127901412349 2.3979400086720375 0.8462620943382769 0.6786116619486878 0.7624368781434824 500.0 7.018787506086644 4.771024667092706 5.78677875200197 1.471127901412349 2.6989700043360187 0.8462620943382769 0.6786116619486878 0.7624368781434824 1000.0 7.018787506086644 4.771024667092706 5.78677875200197 1.471127901412349 3.0 0.8462620943382769 0.6786116619486878 0.7624368781434824 2500.0 7.018787506086644 4.771024667092706 5.78677875200197 1.471127901412349 3.3979400086720375 0.8462620943382769 0.6786116619486878 0.7624368781434824 5000.0 7.018787506086644 4.771024667092706 5.78677875200197 1.471127901412349 3.6989700043360187 0.8462620943382769 0.6786116619486878 0.7624368781434824 10000.0 7.018787506086644 4.771024667092706 5.78677875200197 1.471127901412349 4.0 0.8462620943382769 0.6786116619486878 0.7624368781434824 ==> diazepam_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 7.65650986587006e-08 3.079334967212975e-08 4.8556110384569293e-08 2.4864166930172478 -6.0 -7.11596915352786 -7.511543066374606 -7.313756109951234 5e-06 3.82825493293503e-07 1.539667483606488e-07 2.427805519228464e-07 2.486416693017247 -5.301029995663981 -6.416999149191842 -6.812573062038587 -6.614786105615215 1e-05 7.65650986587006e-07 3.079334967212976e-07 4.855611038456929e-07 2.486416693017247 -5.0 -6.11596915352786 -6.511543066374606 -6.313756109951234 5e-05 3.82825493293503e-06 1.5396674836064876e-06 2.4278055192284644e-06 2.4864166930172478 -4.301029995663981 -5.416999149191842 -5.812573062038587 -5.614786105615215 0.0001 7.65650986587006e-06 3.079334967212975e-06 4.8556110384569295e-06 2.4864166930172478 -4.0 -5.11596915352786 -5.511543066374606 -5.313756109951234 0.001 7.656509865870059e-05 3.0793349672129754e-05 4.855611038456929e-05 2.486416693017247 -3.0 -4.11596915352786 -4.511543066374606 -4.313756109951234 0.01 0.000765650986587006 0.00030793349672129754 0.0004855611038456929 2.4864166930172473 -2.0 -3.1159691535278604 -3.5115430663746063 -3.3137561099512336 0.1 0.007656509865870059 0.0030793349672129755 0.00485561103845693 2.486416693017247 -1.0 -2.1159691535278604 -2.5115430663746063 -2.3137561099512336 1.0 0.07656509865870059 0.03079334967212976 0.04855611038456931 2.4864166930172464 0.0 -1.1159691535278606 -1.5115430663746061 -1.3137561099512334 10.0 1.0343670495023127 0.42035450830651366 0.6593943073017873 2.460701691221244 1.0 0.014674677333232604 -0.3763842904089638 -0.18085480653786562 25.0 2.1377004416782444 0.8946242605383204 1.382909496998571 2.38949527301208 1.3979400086720377 0.3299468469714469 -0.04835932874881004 0.14079375911131842 50.0 3.860596697678346 1.7108474501944284 2.569998446780081 2.2565405800731155 1.6989700043360187 0.5866544348482772 0.23321128686875245 0.4099328608585148 75.0 5.442804548541654 2.5628406875957963 3.7348414894924282 2.1237389334752423 1.8750612633917 0.7358227390545518 0.4087216102230804 0.5722721746388161 100.0 6.883457703461088 3.455030771605455 4.876736427212638 1.9922999702438369 2.0 0.8378066481646083 0.5384519196925432 0.6881292839285758 250.0 8.001321465429749 4.154032000270883 5.765218591853174 1.9261578786364635 2.3979400086720375 0.9031617192106495 0.6184698377666139 0.7608157784886317 500.0 8.001321465429749 4.154032000270883 5.765218591853174 1.9261578786364635 2.6989700043360187 0.9031617192106495 0.6184698377666139 0.7608157784886317 1000.0 8.001321465429749 4.154032000270883 5.765218591853174 1.9261578786364635 3.0 0.9031617192106495 0.6184698377666139 0.7608157784886317 2500.0 8.001321465429749 4.154032000270883 5.765218591853174 1.9261578786364635 3.3979400086720375 0.9031617192106495 0.6184698377666139 0.7608157784886317 5000.0 8.001321465429749 4.154032000270883 5.765218591853174 1.9261578786364635 3.6989700043360187 0.9031617192106495 0.6184698377666139 0.7608157784886317 10000.0 8.001321465429749 4.154032000270883 5.765218591853174 1.9261578786364635 4.0 0.9031617192106495 0.6184698377666139 0.7608157784886317 ==> diclofenac_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 4.5800081803256964e-08 1.0930388441120375e-13 7.075398820877085e-11 419016.0491548131 -6.0 -7.339133746304616 -12.961364403938905 -10.15024907512176 5e-06 2.2900040901628487e-07 5.465194220560186e-13 3.537699410438542e-10 419016.04915481334 -5.301029995663981 -6.640163741968597 -12.262394399602886 -9.451279070785741 1e-05 4.5800081803256974e-07 1.0930388441120372e-12 7.075398820877085e-10 419016.04915481334 -5.0 -6.339133746304616 -11.961364403938905 -9.15024907512176 5e-05 2.2900040901628488e-06 5.465194220560185e-12 3.5376994104385426e-09 419016.0491548134 -4.301029995663981 -5.640163741968597 -11.262394399602886 -8.451279070785741 0.0001 4.5800081803256975e-06 1.093038844112037e-11 7.075398820877086e-09 419016.0491548134 -4.0 -5.339133746304616 -10.961364403938905 -8.15024907512176 0.001 4.580008180325697e-05 1.0930388441120372e-10 7.075398820877085e-08 419016.0491548133 -3.0 -4.339133746304616 -9.961364403938905 -7.15024907512176 0.01 0.00045800081803256965 1.093038844112037e-09 7.075398820877071e-07 419016.04915481334 -2.0 -3.3391337463046162 -8.961364403938905 -6.150249075121761 0.1 0.004580008180325698 1.0930388441120371e-08 7.075398820877086e-06 419016.0491548134 -1.0 -2.339133746304616 -7.961364403938905 -5.15024907512176 1.0 0.045800081803256974 1.0930388441120371e-07 7.075398820877072e-05 419016.0491548134 0.0 -1.339133746304616 -6.961364403938905 -4.150249075121761 10.0 0.4580008180325697 1.093038844112037e-06 0.0007075398820877079 419016.04915481334 1.0 -0.339133746304616 -5.961364403938905 -3.1502490751217604 25.0 1.9341393735277668 5.130929455874241e-06 0.0031502274018552637 376956.92177436413 1.3979400086720377 0.2864877660102318 -5.289803956331783 -2.5016580951607756 50.0 2.914435214861168 8.70606110792457e-06 0.005037186821596813 334759.33361050545 1.6989700043360187 0.46455440580711305 -5.060178288850881 -2.297811941521884 75.0 3.6984325686163864 1.2978930816264512e-05 0.00692832594763638 284956.64403894544 1.8750612633917 0.5680177048698105 -4.886761082552734 -2.159371688841462 100.0 4.3451438577095365 1.8085712138091908e-05 0.008864819288013307 240252.84846582552 2.0 0.6380041595131527 -4.742664385904044 -2.052330113195446 250.0 6.475650499785274 7.795888982214243e-05 0.022468522956337434 83064.93992614573 2.3979400086720375 0.8112834012131056 -4.108134354104832 -1.6484254764458632 500.0 7.555689486775228 0.0005283861934214239 0.0631848241794771 14299.558884857259 2.6989700043360187 0.8782741015855473 -3.2770485388985917 -1.1993872186565222 1000.0 7.725480317862181 0.0010589036579334887 0.09044633418706054 7295.734848002036 3.0 0.8879254904156197 -2.975143551442281 -1.0436090305133305 2500.0 7.725480317862181 0.0010589036579334887 0.09044633418706054 7295.734848002036 3.3979400086720375 0.8879254904156197 -2.975143551442281 -1.0436090305133305 5000.0 7.725480317862181 0.0010589036579334887 0.09044633418706054 7295.734848002036 3.6989700043360187 0.8879254904156197 -2.975143551442281 -1.0436090305133305 10000.0 7.725480317862181 0.0010589036579334887 0.09044633418706054 7295.734848002036 4.0 0.8879254904156197 -2.975143551442281 -1.0436090305133305 ==> diclofenac_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 4.651646723076326e-08 1.0815249710049636e-13 7.092864081103252e-11 430100.7233105279 -6.0 -7.332393275896403 -12.96596344881438 -10.149178362355391 5e-06 2.3258233615381633e-07 5.407624855024818e-13 3.546432040551625e-10 430100.723310528 -5.301029995663981 -6.6334232715603845 -12.266993444478361 -9.450208358019372 1e-05 4.6516467230763265e-07 1.0815249710049637e-12 7.092864081103251e-10 430100.723310528 -5.0 -6.332393275896403 -11.96596344881438 -9.149178362355391 5e-05 2.3258233615381634e-06 5.407624855024819e-12 3.5464320405516254e-09 430100.723310528 -4.301029995663981 -5.6334232715603845 -11.266993444478361 -8.450208358019372 0.0001 4.651646723076327e-06 1.0815249710049638e-11 7.0928640811032515e-09 430100.723310528 -4.0 -5.332393275896403 -10.96596344881438 -8.149178362355391 0.001 4.651646723076327e-05 1.0815249710049639e-10 7.092864081103252e-08 430100.72331052786 -3.0 -4.332393275896403 -9.96596344881438 -7.149178362355391 0.01 0.00046516467230763264 1.0815249710049637e-09 7.092864081103252e-07 430100.723310528 -2.0 -3.332393275896403 -8.96596344881438 -6.149178362355391 0.1 0.004651646723076327 1.0815249710049637e-08 7.0928640811032515e-06 430100.723310528 -1.0 -2.332393275896403 -7.96596344881438 -5.149178362355391 1.0 0.04651646723076326 1.0815249710049635e-07 7.092864081103252e-05 430100.723310528 0.0 -1.3323932758964032 -6.96596344881438 -4.149178362355391 10.0 0.4651646723076327 1.0815249710049636e-06 0.0007092864081103245 430100.72331052803 1.0 -0.33239327589640305 -5.96596344881438 -3.1491783623553915 25.0 2.090468940059905 5.076881173153564e-06 0.0032577695444663372 411762.43224171933 1.3979400086720377 0.3202437192383583 -5.294403001347736 -2.487079641054689 50.0 3.0135333512012714 8.614353035110222e-06 0.005095060369644956 349827.00835672364 1.6989700043360187 0.47907600222919244 -5.064777333866833 -2.29285066581882 75.0 3.7860480430421974 1.2842213106889947e-05 0.006972892929170183 294812.7407269821 1.8750612633917 0.5781861206409151 -4.891360127568688 -2.156587003463886 100.0 4.380321240791307 1.7895200518072416e-05 0.008853627896943278 244776.31510010787 2.0 0.6415059616427176 -4.747263430919997 -2.0528787346386395 250.0 6.4897335540190255 7.713768497925118e-05 0.022374159704650252 84131.81644956887 2.3979400086720375 0.8122268665392476 -4.112733399120786 -1.6502532662907692 500.0 7.588636565837279 0.000522820268843169 0.06298803862245714 14514.809425098345 2.6989700043360187 0.8801637541400569 -3.2816475839145443 -1.2007419148872436 1000.0 7.726398262406421 0.0010477493583528493 0.08997404526759313 7374.281072863621 3.0 0.8879770903875783 -2.979742596458234 -1.0458827530353276 2500.0 7.726398262406421 0.0010477493583528493 0.08997404526759313 7374.281072863621 3.3979400086720375 0.8879770903875783 -2.979742596458234 -1.0458827530353276 5000.0 7.726398262406421 0.0010477493583528493 0.08997404526759313 7374.281072863621 3.6989700043360187 0.8879770903875783 -2.979742596458234 -1.0458827530353276 10000.0 7.726398262406421 0.0010477493583528493 0.08997404526759313 7374.281072863621 4.0 0.8879770903875783 -2.979742596458234 -1.0458827530353276 ==> diclofenac_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 9.261322297786318e-08 1.0918660511870591e-11 1.0055905432160031e-09 8482.104822031564 -6.0 -7.033327001910481 -10.961830637087768 -8.997578819499125 5e-06 4.630661148893159e-07 5.459330255935295e-11 5.027952716080015e-09 8482.104822031566 -5.301029995663981 -6.334356997574463 -10.26286063275175 -8.298608815163107 1e-05 9.261322297786318e-07 1.091866051187059e-10 1.0055905432160032e-08 8482.104822031566 -5.0 -6.033327001910481 -9.961830637087768 -7.997578819499125 5e-05 4.630661148893159e-06 5.459330255935295e-10 5.0279527160800155e-08 8482.104822031566 -4.301029995663981 -5.334356997574463 -9.26286063275175 -7.2986088151631066 0.0001 9.261322297786317e-06 1.091866051187059e-09 1.0055905432160032e-07 8482.104822031566 -4.0 -5.033327001910481 -8.961830637087768 -6.997578819499125 0.001 9.261322297786319e-05 1.091866051187059e-08 1.0055905432160053e-06 8482.104822031566 -3.0 -4.033327001910481 -7.961830637087767 -5.997578819499124 0.01 0.0009261322297786316 1.091866051187059e-07 1.0055905432160052e-05 8482.104822031564 -2.0 -3.033327001910481 -6.961830637087767 -4.997578819499124 0.1 0.009261322297786317 1.0918660511870588e-06 0.00010055905432160052 8482.104822031566 -1.0 -2.033327001910481 -5.961830637087767 -3.9975788194991244 1.0 0.09261322297786317 1.0918660511870587e-05 0.0010055905432160052 8482.104822031568 0.0 -1.0333270019104812 -4.961830637087767 -2.9975788194991244 10.0 0.9261322297786317 0.0001091866051187059 0.010055905432160053 8482.104822031566 1.0 -0.03332700191048114 -3.961830637087768 -1.9975788194991244 25.0 3.357978982426747 0.0005005281860842381 0.04099711122729325 6708.870900352463 1.3979400086720377 0.5260779735635988 -3.300571461209276 -1.3872467438228386 50.0 4.622940146554232 0.0008168732961648986 0.06145206551035363 5659.311141958323 1.6989700043360187 0.6649182706413064 -3.087845300926281 -1.2114635151424873 75.0 4.991437072829323 0.001165809724867649 0.07628280199736596 4281.5195021606005 1.8750612633917 0.6982256003223529 -2.9333723262350144 -1.1175733629563307 100.0 5.347038885921944 0.0015506951787439018 0.09105837370036497 3448.156000751332 2.0 0.7281133424844655 -2.8094735633726415 -1.0406801104440881 250.0 6.359389354635208 0.004851368586373816 0.17564663886222615 1310.8444022367244 2.3979400086720375 0.8034154155470743 -2.314135728270826 -0.7553601563618759 500.0 7.228592001075945 0.01720890101326151 0.3526983473334825 420.0496008144537 2.6989700043360187 0.859053712825292 -1.7642468634967237 -0.45259657533571584 1000.0 7.490843844080307 0.026301974647324436 0.4438738389160444 284.8015764794417 3.0 0.8745307437588883 -1.580011645189173 -0.3527404507151424 2500.0 7.490843844080307 0.026301974647324436 0.4438738389160444 284.8015764794417 3.3979400086720375 0.8745307437588883 -1.580011645189173 -0.3527404507151424 5000.0 7.490843844080307 0.026301974647324436 0.4438738389160444 284.8015764794417 3.6989700043360187 0.8745307437588883 -1.580011645189173 -0.3527404507151424 10000.0 7.490843844080307 0.026301974647324436 0.4438738389160444 284.8015764794417 4.0 0.8745307437588883 -1.580011645189173 -0.3527404507151424 ==> diclofenac_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 5.7726178387525786e-08 8.393126863716923e-12 6.960625967282384e-10 6877.791712773131 -6.0 -7.238627192893653 -11.076076212393172 -9.157351702643412 5e-06 2.88630891937629e-07 4.196563431858461e-11 3.480312983641192e-09 6877.7917127731325 -5.301029995663981 -6.5396571885576344 -10.377106208057153 -8.458381698307393 1e-05 5.77261783875258e-07 8.393126863716922e-11 6.960625967282385e-09 6877.7917127731325 -5.0 -6.238627192893653 -10.076076212393172 -8.157351702643412 5e-05 2.88630891937629e-06 4.196563431858461e-10 3.480312983641192e-08 6877.791712773132 -4.301029995663981 -5.5396571885576344 -9.377106208057153 -7.458381698307393 0.0001 5.77261783875258e-06 8.393126863716922e-10 6.960625967282385e-08 6877.791712773132 -4.0 -5.238627192893653 -9.076076212393172 -7.157351702643412 0.001 5.7726178387525796e-05 8.393126863716922e-09 6.960625967282384e-07 6877.7917127731325 -3.0 -4.238627192893653 -8.076076212393172 -6.157351702643412 0.01 0.0005772617838752579 8.393126863716922e-08 6.9606259672823844e-06 6877.791712773132 -2.0 -3.238627192893653 -7.076076212393172 -5.157351702643412 0.1 0.005772617838752579 8.393126863716924e-07 6.960625967282385e-05 6877.791712773131 -1.0 -2.238627192893653 -6.076076212393172 -4.157351702643412 1.0 0.05772617838752579 8.393126863716923e-06 0.0006960625967282378 6877.791712773131 0.0 -1.238627192893653 -5.076076212393172 -3.1573517026434126 10.0 0.577261783875258 8.393126863716922e-05 0.006960625967282377 6877.791712773132 1.0 -0.238627192893653 -4.076076212393172 -2.1573517026434126 25.0 2.546027102316749 0.00038475384047138156 0.03129846171236843 6617.288339987669 1.3979400086720377 0.4058630223828224 -3.4148170365069976 -1.5044770070620876 50.0 3.6392298078857532 0.0006279269512128816 0.04780345675815446 5795.626069013832 1.6989700043360187 0.561009481017789 -3.2020908762156726 -1.3205406975989418 75.0 4.496983851899799 0.0008961528668979267 0.06348216262284774 5018.099052080601 1.8750612633917 0.6529213280741901 -3.0476179015125044 -1.1973482867191572 100.0 5.078336431636885 0.0011920126419651136 0.07780386382862467 4260.304171996786 2.0 0.7057214688030716 -2.9237191386338903 -1.1089988349154094 250.0 6.616701987913984 0.003729225942915644 0.15708334319675768 1774.2829448249538 2.3979400086720375 0.8206415747344126 -2.4283813032064447 -0.803869864236016 500.0 7.394061937433073 0.013228407682339112 0.3127485663225827 558.9532856100802 2.6989700043360187 0.8688830841830908 -1.8784924291603662 -0.5048046724886377 1000.0 7.565184896111235 0.020218215094287287 0.3910940238071024 374.1766946701838 3.0 0.8788195468178377 -1.6942571874649857 -0.407718820323574 2500.0 7.565184896111235 0.020218215094287287 0.3910940238071024 374.1766946701838 3.3979400086720375 0.8788195468178377 -1.6942571874649857 -0.407718820323574 5000.0 7.565184896111235 0.020218215094287287 0.3910940238071024 374.1766946701838 3.6989700043360187 0.8788195468178377 -1.6942571874649857 -0.407718820323574 10000.0 7.565184896111235 0.020218215094287287 0.3910940238071024 374.1766946701838 4.0 0.8788195468178377 -1.6942571874649857 -0.407718820323574 ==> diclofenac_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 6.077972711071672e-08 2.2268014178088373e-12 3.678918081504102e-10 27294.632841811148 -6.0 -7.216241254150383 -11.652318510848861 -9.434279882499622 5e-06 3.0389863555358366e-07 1.1134007089044188e-11 1.8394590407520507e-09 27294.63284181115 -5.301029995663981 -6.517271249814364 -10.953348506512842 -8.735309878163603 1e-05 6.077972711071673e-07 2.2268014178088375e-11 3.678918081504102e-09 27294.63284181115 -5.0 -6.216241254150383 -10.652318510848861 -8.434279882499622 5e-05 3.038986355535836e-06 1.1134007089044186e-10 1.8394590407520506e-08 27294.63284181115 -4.301029995663981 -5.517271249814364 -9.953348506512842 -7.735309878163603 0.0001 6.077972711071672e-06 2.2268014178088372e-10 3.678918081504102e-08 27294.63284181115 -4.0 -5.216241254150383 -9.652318510848861 -7.434279882499622 0.001 6.0779727110716724e-05 2.226801417808837e-09 3.678918081504102e-07 27294.632841811155 -3.0 -4.216241254150383 -8.652318510848861 -6.434279882499622 0.01 0.0006077972711071672 2.2268014178088372e-08 3.6789180815041022e-06 27294.632841811148 -2.0 -3.2162412541503826 -7.652318510848861 -5.434279882499622 0.1 0.006077972711071673 2.2268014178088369e-07 3.678918081504102e-05 27294.63284181116 -1.0 -2.2162412541503826 -6.652318510848861 -4.434279882499622 1.0 0.060779727110716726 2.2268014178088364e-06 0.0003678918081504102 27294.632841811163 0.0 -1.2162412541503824 -5.652318510848861 -3.434279882499622 10.0 0.6077972711071673 2.2268014178088375e-05 0.003678918081504102 27294.63284181115 1.0 -0.2162412541503824 -4.652318510848861 -2.434279882499622 25.0 2.775807097735151 0.00010293431307645171 0.01690342559477537 26966.78119057825 1.3979400086720377 0.44338928191967386 -3.9874398293609667 -1.7720252737206463 50.0 3.8462574230535993 0.00017028376716258568 0.02559209259663277 22587.340456129452 1.6989700043360187 0.5850383474194684 -3.7688267505560584 -1.591894201568295 75.0 4.50513152281343 0.0002467170841373438 0.03333905986922488 18260.31439438336 1.8750612633917 0.6537074742936242 -3.6078007763729145 -1.4770466510396452 100.0 4.962734683893521 0.0003334594642049736 0.040680103843065245 14882.572596119167 2.0 0.6957210577076964 -3.4769569519785213 -1.3906179471354125 250.0 6.397697945828779 0.0011629128359357242 0.0862552320827201 5501.442367932027 2.3979400086720375 0.8060237319099425 -2.9344528358225164 -1.064214551956287 500.0 7.406710660301444 0.005127186105943962 0.19487325108450512 1444.5956334050022 2.6989700043360187 0.8696253794715159 -2.2901209183080677 -0.7102477694182759 1000.0 7.609220940798914 0.00859175918142821 0.2556884703728834 885.6417853571672 3.0 0.8813401944273662 -2.0659179043217284 -0.5922888549471812 2500.0 7.609220940798914 0.00859175918142821 0.2556884703728834 885.6417853571672 3.3979400086720375 0.8813401944273662 -2.0659179043217284 -0.5922888549471812 5000.0 7.609220940798914 0.00859175918142821 0.2556884703728834 885.6417853571672 3.6989700043360187 0.8813401944273662 -2.0659179043217284 -0.5922888549471812 10000.0 7.609220940798914 0.00859175918142821 0.2556884703728834 885.6417853571672 4.0 0.8813401944273662 -2.0659179043217284 -0.5922888549471812 ==> furosemide_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.6104307646378378e-08 1.7253323554639813e-12 1.666891809465829e-10 9334.03213321619 -6.0 -7.793057941556541 -11.76312723320472 -9.77809258738063 5e-06 8.05215382318919e-08 8.626661777319907e-12 8.334459047329145e-10 9334.03213321619 -5.301029995663981 -7.0940879372205226 -11.064157228868702 -9.079122583044612 1e-05 1.610430764637838e-07 1.7253323554639814e-11 1.6668918094658291e-09 9334.03213321619 -5.0 -6.793057941556541 -10.76312723320472 -8.77809258738063 5e-05 8.05215382318919e-07 8.626661777319906e-11 8.334459047329143e-09 9334.032133216191 -4.301029995663981 -6.0940879372205226 -10.064157228868702 -8.079122583044612 0.0001 1.610430764637838e-06 1.7253323554639812e-10 1.666891809465829e-08 9334.032133216191 -4.0 -5.793057941556541 -9.76312723320472 -7.77809258738063 0.001 1.610430764637838e-05 1.7253323554639817e-09 1.666891809465829e-07 9334.03213321619 -3.0 -4.793057941556541 -8.76312723320472 -6.77809258738063 0.01 0.00016104307646378377 1.7253323554639814e-08 1.666891809465829e-06 9334.03213321619 -2.0 -3.7930579415565413 -7.76312723320472 -5.77809258738063 0.1 0.001610430764637838 1.7253323554639817e-07 1.666891809465829e-05 9334.032133216188 -1.0 -2.7930579415565413 -6.76312723320472 -4.77809258738063 1.0 0.01610430764637838 1.7253323554639815e-06 0.00016668918094658273 9334.03213321619 0.0 -1.7930579415565413 -5.76312723320472 -3.778092587380631 10.0 0.1610430764637838 1.7253323554639812e-05 0.0016668918094658273 9334.032133216191 1.0 -0.7930579415565413 -4.76312723320472 -2.778092587380631 25.0 0.40260769115945944 4.313330888659954e-05 0.004167229523664567 9334.032133216188 1.3979400086720377 -0.3951179328845037 -4.365187224532683 -2.3801525787085933 50.0 0.8052153823189189 8.626661777319908e-05 0.008334459047329136 9334.032133216188 1.6989700043360187 -0.0940879372205225 -4.064157228868702 -2.079122583044612 75.0 1.2078230734783786 0.0001293999266597986 0.012501688570993706 9334.032133216191 1.8750612633917 0.08200332183515885 -3.88806596981302 -1.9030313239889307 100.0 1.6104307646378377 0.00017253323554639816 0.016668918094658283 9334.032133216188 2.0 0.2069420584434587 -3.76312723320472 -1.7780925873806306 250.0 4.026076911594594 0.00043133308886599534 0.041672295236645694 9334.032133216188 2.3979400086720375 0.6048820671154963 -3.3651872245326824 -1.380152578708593 500.0 8.052153823189188 0.0008626661777319907 0.0833445904732914 9334.032133216188 2.6989700043360187 0.9059120627794774 -3.064157228868701 -1.0791225830446118 1000.0 14.825643880002119 0.002258454891205216 0.1829837368075575 6564.507415107357 3.0 1.171013563922275 -2.646188579309495 -0.73758750769361 2500.0 14.825643880002119 0.002258454891205216 0.1829837368075575 6564.507415107357 3.3979400086720375 1.171013563922275 -2.646188579309495 -0.73758750769361 5000.0 14.825643880002119 0.002258454891205216 0.1829837368075575 6564.507415107357 3.6989700043360187 1.171013563922275 -2.646188579309495 -0.73758750769361 10000.0 14.825643880002119 0.002258454891205216 0.1829837368075575 6564.507415107357 4.0 1.171013563922275 -2.646188579309495 -0.73758750769361 ==> furosemide_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.6168059994269305e-08 1.7024033614401157e-12 1.6590527322001994e-10 9497.196939620844 -6.0 -7.791342087968027 -11.768937531858347 -9.780139809913187 5e-06 8.084029997134655e-08 8.51201680720058e-12 8.295263661000996e-10 9497.196939620844 -5.301029995663981 -7.092372083632008 -11.069967527522328 -9.081169805577169 1e-05 1.616805999426931e-07 1.702403361440116e-11 1.6590527322001994e-09 9497.196939620844 -5.0 -6.791342087968027 -10.768937531858347 -8.780139809913187 5e-05 8.084029997134654e-07 8.512016807200577e-11 8.295263661000996e-09 9497.196939620848 -4.301029995663981 -6.092372083632008 -10.069967527522328 -8.081169805577169 0.0001 1.6168059994269308e-06 1.7024033614401154e-10 1.6590527322001994e-08 9497.196939620848 -4.0 -5.791342087968027 -9.768937531858347 -7.780139809913187 0.001 1.616805999426931e-05 1.7024033614401154e-09 1.6590527322001994e-07 9497.19693962085 -3.0 -4.791342087968027 -8.768937531858347 -6.780139809913187 0.01 0.00016168059994269308 1.7024033614401156e-08 1.6590527322001994e-06 9497.196939620846 -2.0 -3.791342087968027 -7.768937531858347 -5.780139809913187 0.1 0.001616805999426931 1.7024033614401156e-07 1.6590527322001994e-05 9497.196939620848 -1.0 -2.791342087968027 -6.768937531858347 -4.780139809913187 1.0 0.01616805999426931 1.7024033614401158e-06 0.0001659052732200201 9497.196939620848 0.0 -1.7913420879680266 -5.768937531858347 -3.780139809913187 10.0 0.16168059994269307 1.7024033614401154e-05 0.0016590527322002011 9497.196939620848 1.0 -0.7913420879680267 -4.768937531858347 -2.780139809913187 25.0 0.4042014998567327 4.256008403600289e-05 0.004147631830500501 9497.196939620848 1.3979400086720377 -0.39340207929598914 -4.370997523186309 -2.3821998012411494 50.0 0.8084029997134654 8.512016807200577e-05 0.008295263661001005 9497.196939620848 1.6989700043360187 -0.09237208363200791 -4.069967527522328 -2.081169805577168 75.0 1.2126044995701981 0.0001276802521080087 0.012442895491501509 9497.196939620844 1.8750612633917 0.08371917542367333 -3.893876268466647 -1.9050785465214868 100.0 1.6168059994269308 0.00017024033614401155 0.01659052732200201 9497.196939620848 2.0 0.20865791203197326 -3.768937531858347 -1.7801398099131869 250.0 4.042014998567327 0.00042560084036002884 0.04147631830500501 9497.196939620848 2.3979400086720375 0.6065979207040109 -3.3709975231863094 -1.3821998012411494 500.0 8.084029997134653 0.0008512016807200577 0.08295263661001004 9497.196939620848 2.6989700043360187 0.907627916367992 -3.069967527522328 -1.0811698055771681 1000.0 14.827984962087294 0.002228440906631041 0.18177812919167494 6653.97270260321 3.0 1.1710821369147273 -2.6519988779629644 -0.7404583705241186 2500.0 14.827984962087294 0.002228440906631041 0.18177812919167494 6653.97270260321 3.3979400086720375 1.1710821369147273 -2.6519988779629644 -0.7404583705241186 5000.0 14.827984962087294 0.002228440906631041 0.18177812919167494 6653.97270260321 3.6989700043360187 1.1710821369147273 -2.6519988779629644 -0.7404583705241186 10000.0 14.827984962087294 0.002228440906631041 0.18177812919167494 6653.97270260321 4.0 1.1710821369147273 -2.6519988779629644 -0.7404583705241186 ==> furosemide_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.5857436372020058e-08 4.2505189419114165e-11 8.20989242739672e-10 373.07059652554153 -6.0 -7.799767022534063 -10.37155804410259 -9.085662533318327 5e-06 7.92871818601003e-08 2.1252594709557093e-10 4.1049462136983595e-09 373.0705965255414 -5.301029995663981 -7.100797018198044 -9.672588039766572 -8.386692528982309 1e-05 1.585743637202006e-07 4.2505189419114186e-10 8.20989242739672e-09 373.0705965255414 -5.0 -6.799767022534063 -9.37155804410259 -8.085662533318327 5e-05 7.92871818601003e-07 2.1252594709557084e-09 4.104946213698368e-08 373.0705965255416 -4.301029995663981 -6.100797018198044 -8.672588039766572 -7.386692528982308 0.0001 1.585743637202006e-06 4.250518941911417e-09 8.209892427396737e-08 373.0705965255416 -4.0 -5.799767022534063 -8.37155804410259 -7.0856625333183265 0.001 1.585743637202006e-05 4.250518941911417e-08 8.209892427396753e-07 373.0705965255415 -3.0 -4.799767022534063 -7.371558044102589 -6.085662533318326 0.01 0.00015857436372020058 4.2505189419114167e-07 8.209892427396737e-06 373.07059652554153 -2.0 -3.799767022534063 -6.371558044102589 -5.0856625333183265 0.1 0.0015857436372020061 4.250518941911417e-06 8.209892427396737e-05 373.0705965255416 -1.0 -2.799767022534063 -5.371558044102589 -4.0856625333183265 1.0 0.01585743637202006 4.2505189419114177e-05 0.0008209892427396737 373.0705965255415 0.0 -1.7997670225340632 -4.371558044102589 -3.0856625333183265 10.0 0.1585743637202006 0.0004250518941911418 0.008209892427396738 373.0705965255415 1.0 -0.7997670225340631 -3.37155804410259 -2.0856625333183265 25.0 0.3964359093005015 0.0010626297354778542 0.02052473106849186 373.07059652554153 1.3979400086720377 -0.4018270138620254 -2.973618035430552 -1.6877225246462886 50.0 0.792871818601003 0.0021252594709557085 0.041049462136983676 373.07059652554153 1.6989700043360187 -0.10079701819804422 -2.672588039766571 -1.3866925289823078 75.0 1.1893077279015043 0.0031878892064335623 0.06157419320547553 373.07059652554153 1.8750612633917 0.07529424085763696 -2.4964967807108898 -1.2106012699266264 100.0 1.585743637202006 0.004250518941911417 0.08209892427396737 373.07059652554153 2.0 0.200232977465937 -2.37155804410259 -1.0856625333183265 250.0 3.9643590930050148 0.010626297354778541 0.20524731068491847 373.07059652554153 2.3979400086720375 0.5981729861379745 -1.9736180354305521 -0.6877225246462888 500.0 7.9287181860100295 0.021252594709557083 0.410494621369837 373.07059652554153 2.6989700043360187 0.8992029818019558 -1.6725880397665709 -0.38669252898230755 1000.0 14.413077594728923 0.049457829706352784 0.8442982513451938 291.4215540856534 3.0 1.1587567247209503 -1.305764945136773 -0.07350411020791138 2500.0 14.413077594728923 0.049457829706352784 0.8442982513451938 291.4215540856534 3.3979400086720375 1.1587567247209503 -1.305764945136773 -0.07350411020791138 5000.0 14.413077594728923 0.049457829706352784 0.8442982513451938 291.4215540856534 3.6989700043360187 1.1587567247209503 -1.305764945136773 -0.07350411020791138 10000.0 14.413077594728923 0.049457829706352784 0.8442982513451938 291.4215540856534 4.0 1.1587567247209503 -1.305764945136773 -0.07350411020791138 ==> furosemide_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.644491488083622e-08 3.1410724558910775e-11 7.187118280066639e-10 523.5445890461331 -6.0 -7.783968370091257 -10.502922045508294 -9.143445207799775 5e-06 8.222457440418111e-08 1.570536227945539e-10 3.5935591400333185e-09 523.544589046133 -5.301029995663981 -7.084998365755238 -9.803952041172275 -8.444475203463757 1e-05 1.6444914880836221e-07 3.141072455891078e-10 7.1871182800666386e-09 523.544589046133 -5.0 -6.783968370091257 -9.502922045508294 -8.143445207799775 5e-05 8.22245744041811e-07 1.5705362279455392e-09 3.5935591400333185e-08 523.5445890461328 -4.301029995663981 -6.084998365755238 -8.803952041172275 -7.444475203463757 0.0001 1.644491488083622e-06 3.1410724558910783e-09 7.187118280066638e-08 523.5445890461328 -4.0 -5.783968370091257 -8.502922045508294 -7.143445207799775 0.001 1.644491488083622e-05 3.141072455891077e-08 7.187118280066638e-07 523.5445890461331 -3.0 -4.783968370091257 -7.502922045508295 -6.143445207799775 0.01 0.0001644491488083622 3.1410724558910777e-07 7.187118280066638e-06 523.544589046133 -2.0 -3.783968370091257 -6.502922045508295 -5.143445207799775 0.1 0.001644491488083622 3.141072455891078e-06 7.187118280066639e-05 523.544589046133 -1.0 -2.783968370091257 -5.502922045508295 -4.143445207799775 1.0 0.016444914880836218 3.141072455891077e-05 0.000718711828006663 523.544589046133 0.0 -1.783968370091257 -4.502922045508295 -3.143445207799776 10.0 0.1644491488083622 0.0003141072455891078 0.007187118280066631 523.544589046133 1.0 -0.7839683700912569 -3.502922045508295 -2.143445207799776 25.0 0.4111228720209055 0.0007852681139727695 0.01796779570016659 523.544589046133 1.3979400086720377 -0.3860283614192192 -3.104982036836257 -1.745505199127738 50.0 0.822245744041811 0.001570536227945539 0.035935591400333165 523.544589046133 1.6989700043360187 -0.08499836575523799 -2.803952041172276 -1.444475203463757 75.0 1.2333686160627164 0.0023558043419183087 0.05390338710049974 523.5445890461328 1.8750612633917 0.09109289330044319 -2.6278607821165947 -1.2683839444080758 100.0 1.644491488083622 0.003141072455891078 0.0718711828006663 523.544589046133 2.0 0.2160316299087432 -2.502922045508295 -1.1434452077997759 250.0 4.111228720209055 0.007852681139727695 0.17967795700166578 523.544589046133 2.3979400086720375 0.6139716385807807 -2.1049820368362573 -0.7455051991277383 500.0 8.22245744041811 0.01570536227945539 0.35935591400333167 523.544589046133 2.6989700043360187 0.915001634244762 -1.8039520411722758 -0.4444752034637569 1000.0 14.565452550676802 0.036548661246200424 0.7296216767423322 398.5221908009289 3.0 1.1633239827644701 -1.437128526340486 -0.13690227178800796 2500.0 14.565452550676802 0.036548661246200424 0.7296216767423322 398.5221908009289 3.3979400086720375 1.1633239827644701 -1.437128526340486 -0.13690227178800796 5000.0 14.565452550676802 0.036548661246200424 0.7296216767423322 398.5221908009289 3.6989700043360187 1.1633239827644701 -1.437128526340486 -0.13690227178800796 10000.0 14.565452550676802 0.036548661246200424 0.7296216767423322 398.5221908009289 4.0 1.1633239827644701 -1.437128526340486 -0.13690227178800796 ==> furosemide_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.578693807906455e-08 1.3836564150306036e-11 4.673724226651434e-10 1140.957965255802 -6.0 -7.801702094457493 -10.858971739056487 -9.330336916756991 5e-06 7.893469039532277e-08 6.918282075153019e-11 2.3368621133257167e-09 1140.957965255802 -5.301029995663981 -7.102732090121474 -10.160001734720469 -8.631366912420972 1e-05 1.5786938079064554e-07 1.3836564150306038e-10 4.673724226651433e-09 1140.957965255802 -5.0 -6.801702094457493 -9.858971739056487 -8.330336916756991 5e-05 7.893469039532276e-07 6.918282075153018e-10 2.3368621133257212e-08 1140.957965255802 -4.301029995663981 -6.102732090121474 -9.160001734720469 -7.6313669124209715 0.0001 1.5786938079064552e-06 1.3836564150306036e-09 4.673724226651443e-08 1140.957965255802 -4.0 -5.801702094457493 -8.858971739056487 -7.33033691675699 0.001 1.5786938079064556e-05 1.3836564150306035e-08 4.6737242266514335e-07 1140.9579652558025 -3.0 -4.801702094457493 -7.858971739056488 -6.330336916756991 0.01 0.0001578693807906455 1.3836564150306036e-07 4.673724226651434e-06 1140.957965255802 -2.0 -3.801702094457493 -6.858971739056488 -5.330336916756991 0.1 0.0015786938079064552 1.3836564150306035e-06 4.6737242266514335e-05 1140.9579652558023 -1.0 -2.801702094457493 -5.858971739056488 -4.330336916756991 1.0 0.015786938079064554 1.3836564150306036e-05 0.00046737242266514385 1140.9579652558023 0.0 -1.801702094457493 -4.858971739056488 -3.3303369167569907 10.0 0.15786938079064552 0.00013836564150306033 0.004673724226651439 1140.9579652558025 1.0 -0.8017020944574933 -3.8589717390564884 -2.3303369167569907 25.0 0.3946734519766138 0.00034591410375765075 0.011684310566628593 1140.9579652558027 1.3979400086720377 -0.40376208578545564 -3.461031730384451 -1.9323969080849532 50.0 0.7893469039532276 0.0006918282075153015 0.02336862113325719 1140.9579652558027 1.6989700043360187 -0.10273209012147444 -3.1600017347204696 -1.631366912420972 75.0 1.1840203559298412 0.0010377423112729524 0.03505293169988578 1140.9579652558023 1.8750612633917 0.07335916893420673 -2.9839104756647883 -1.4552756533652909 100.0 1.5786938079064552 0.001383656415030603 0.046737242266514385 1140.9579652558027 2.0 0.19829790554250673 -2.8589717390564884 -1.3303369167569907 250.0 3.9467345197661388 0.0034591410375765085 0.11684310566628593 1140.9579652558025 2.3979400086720375 0.5962379142145444 -2.461031730384451 -0.9323969080849532 500.0 7.8934690395322775 0.006918282075153017 0.2336862113325719 1140.9579652558025 2.6989700043360187 0.8972679098785257 -2.1600017347204696 -0.631366912420972 1000.0 14.616525073298508 0.016885387017627762 0.49679541333984284 865.631629173756 3.0 1.164844135900323 -1.772488980767752 -0.3038224224337145 2500.0 14.616525073298508 0.016885387017627762 0.49679541333984284 865.631629173756 3.3979400086720375 1.164844135900323 -1.772488980767752 -0.3038224224337145 5000.0 14.616525073298508 0.016885387017627762 0.49679541333984284 865.631629173756 3.6989700043360187 1.164844135900323 -1.772488980767752 -0.3038224224337145 10000.0 14.616525073298508 0.016885387017627762 0.49679541333984284 865.631629173756 4.0 1.164844135900323 -1.772488980767752 -0.3038224224337145 ==> haloperidol_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 8.863203241832716e-09 1.2079892137426069e-09 3.272102369325024e-09 7.337154289956474 -6.0 -8.05240929178849 -8.917936943556757 -8.485173117672623 5e-06 4.4316016209163586e-08 6.0399460687130365e-09 1.6360511846625117e-08 7.337154289956472 -5.301029995663981 -7.3534392874524706 -8.218966939220739 -7.7862031133366045 1e-05 8.863203241832717e-08 1.2079892137426073e-08 3.272102369325024e-08 7.337154289956472 -5.0 -7.052409291788489 -7.917936943556757 -7.485173117672623 5e-05 4.4316016209163585e-07 6.039946068713036e-08 1.6360511846625116e-07 7.337154289956473 -4.301029995663981 -6.3534392874524706 -7.2189669392207385 -6.7862031133366045 0.0001 8.863203241832717e-07 1.2079892137426071e-07 3.2721023693250237e-07 7.337154289956473 -4.0 -6.052409291788489 -6.917936943556757 -6.485173117672623 0.001 8.863203241832718e-06 1.207989213742607e-06 3.272102369325024e-06 7.337154289956475 -3.0 -5.052409291788489 -5.917936943556758 -5.485173117672623 0.01 8.863203241832715e-05 1.2079892137426067e-05 3.2721023693250236e-05 7.337154289956475 -2.0 -4.052409291788489 -4.917936943556758 -4.485173117672623 0.1 0.0008863203241832717 0.00012079892137426073 0.0003272102369325024 7.337154289956472 -1.0 -3.052409291788489 -3.9179369435567577 -3.4851731176726233 1.0 0.008863203241832715 0.001207989213742607 0.003272102369325024 7.337154289956473 0.0 -2.0524092917884893 -2.9179369435567577 -2.4851731176726233 10.0 0.08863203241832718 0.01207989213742607 0.03272102369325024 7.337154289956474 1.0 -1.052409291788489 -1.9179369435567577 -1.4851731176726233 25.0 0.22215551340410436 0.051054488106692324 0.10649899537989066 4.351341510659154 1.3979400086720377 -0.6533429040694464 -1.2919660738651295 -0.9726544889672879 50.0 0.2627329283913176 0.081561584574034 0.14638618090302127 3.2212827860502538 1.6989700043360187 -0.5804854935540154 -1.0885143453623356 -0.8344999194581755 75.0 0.301823387052867 0.11227528854473344 0.184085056077101 2.6882441449492473 1.8750612633917 -0.520247111563441 -0.9497158201376636 -0.7349814658505522 100.0 0.3413074535329839 0.14319699778662634 0.22107510639626923 2.3834819082000323 2.0 -0.466854227417523 -0.844066087184375 -0.6554601573009491 250.0 0.5733858892702391 0.3331547024046158 0.4370654473906997 1.7210799821575473 2.3979400086720375 -0.24155299902029156 -0.4773540523824471 -0.35945352570136935 500.0 0.7404913204950376 0.4689082571250027 0.5892558820321779 1.579181661323647 2.6989700043360187 -0.1304800275994941 -0.32891211959160216 -0.22969607359554806 1000.0 0.7404913204950376 0.4689082571250027 0.5892558820321779 1.579181661323647 3.0 -0.1304800275994941 -0.32891211959160216 -0.22969607359554806 2500.0 0.7404913204950376 0.4689082571250027 0.5892558820321779 1.579181661323647 3.3979400086720375 -0.1304800275994941 -0.32891211959160216 -0.22969607359554806 5000.0 0.7404913204950376 0.4689082571250027 0.5892558820321779 1.579181661323647 3.6989700043360187 -0.1304800275994941 -0.32891211959160216 -0.22969607359554806 10000.0 0.7404913204950376 0.4689082571250027 0.5892558820321779 1.579181661323647 4.0 -0.1304800275994941 -0.32891211959160216 -0.22969607359554806 ==> haloperidol_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 2.116383361833582e-09 1.2109898697839508e-09 1.600911868829688e-09 1.7476474532451374 -6.0 -8.674405661377492 -8.916859489817586 -8.795632575597539 5e-06 1.058191680916791e-08 6.054949348919753e-09 8.004559344148439e-09 1.7476474532451376 -5.301029995663981 -7.975435657041473 -8.217889485481567 -8.09666257126152 1e-05 2.116383361833582e-08 1.2109898697839507e-08 1.600911868829688e-08 1.7476474532451376 -5.0 -7.674405661377492 -7.916859489817585 -7.795632575597539 5e-05 1.0581916809167913e-07 6.054949348919754e-08 8.004559344148439e-08 1.7476474532451378 -4.301029995663981 -6.975435657041473 -7.2178894854815665 -7.09666257126152 0.0001 2.1163833618335826e-07 1.2109898697839507e-07 1.6009118688296878e-07 1.7476474532451378 -4.0 -6.674405661377492 -6.916859489817585 -6.795632575597539 0.001 2.116383361833582e-06 1.2109898697839507e-06 1.6009118688296879e-06 1.7476474532451374 -3.0 -5.674405661377492 -5.916859489817585 -5.795632575597539 0.01 2.1163833618335823e-05 1.2109898697839505e-05 1.600911868829688e-05 1.7476474532451378 -2.0 -4.674405661377492 -4.916859489817585 -4.795632575597539 0.1 0.00021163833618335825 0.00012109898697839507 0.00016009118688296896 1.7476474532451378 -1.0 -3.6744056613774916 -3.9168594898175852 -3.7956325755975384 1.0 0.0021163833618335825 0.0012109898697839508 0.0016009118688296896 1.7476474532451376 0.0 -2.6744056613774916 -2.9168594898175852 -2.7956325755975384 10.0 0.021163833618335823 0.012109898697839506 0.016009118688296894 1.7476474532451378 1.0 -1.6744056613774914 -1.9168594898175852 -1.7956325755975384 25.0 0.08915365165354092 0.05119497807012397 0.06755900562674454 1.7414530685299505 1.3979400086720377 -1.0498608638121956 -1.2907726386999838 -1.1703167512560897 50.0 0.14081488953038787 0.08182066703444937 0.1073385680441035 1.7210185963297007 1.6989700043360187 -0.8513514211953397 -1.0871369842827714 -0.9692442027390555 75.0 0.1916892857620823 0.11268551047006431 0.14697144286473574 1.7010996796523001 1.8750612633917 -0.717402160801873 -0.9481319235940903 -0.8327670421979816 100.0 0.24184867919183958 0.14379407030972433 0.18648433172796405 1.6819099610360229 2.0 -0.6164562800814473 -0.8422590227491258 -0.7293576514152865 250.0 0.5217119628545749 0.3358402043324749 0.418583148499527 1.5534529699669035 2.3979400086720375 -0.28256920479159103 -0.4738673145273985 -0.37821825965949474 500.0 0.7048181961603419 0.4743833105380209 0.5782335075226783 1.485756729849905 2.6989700043360187 -0.15192289235137332 -0.3238705984564873 -0.23789674540393024 1000.0 0.7048181961603419 0.4743833105380209 0.5782335075226783 1.485756729849905 3.0 -0.15192289235137332 -0.3238705984564873 -0.23789674540393024 2500.0 0.7048181961603419 0.4743833105380209 0.5782335075226783 1.485756729849905 3.3979400086720375 -0.15192289235137332 -0.3238705984564873 -0.23789674540393024 5000.0 0.7048181961603419 0.4743833105380209 0.5782335075226783 1.485756729849905 3.6989700043360187 -0.15192289235137332 -0.3238705984564873 -0.23789674540393024 10000.0 0.7048181961603419 0.4743833105380209 0.5782335075226783 1.485756729849905 4.0 -0.15192289235137332 -0.3238705984564873 -0.23789674540393024 ==> haloperidol_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.6730520346788813e-08 6.299971555125545e-10 3.2465643731061143e-09 26.556501407021685 -6.0 -7.776490551552562 -9.200661411416243 -8.488575981484402 5e-06 8.365260173394408e-08 3.149985777562774e-09 1.6232821865530568e-08 26.556501407021678 -5.301029995663981 -7.077520547216542 -8.501691407080225 -7.789605977148383 1e-05 1.6730520346788816e-07 6.299971555125548e-09 3.246564373106114e-08 26.556501407021678 -5.0 -6.776490551552562 -8.200661411416243 -7.488575981484402 5e-05 8.365260173394407e-07 3.1499857775627734e-08 1.6232821865530568e-07 26.55650140702168 -4.301029995663981 -6.077520547216542 -7.501691407080225 -6.789605977148383 0.0001 1.6730520346788814e-06 6.299971555125547e-08 3.246564373106114e-07 26.55650140702168 -4.0 -5.776490551552562 -7.2006614114162435 -6.488575981484402 0.001 1.6730520346788817e-05 6.299971555125546e-07 3.2465643731061144e-06 26.55650140702169 -3.0 -4.776490551552561 -6.200661411416244 -5.488575981484402 0.01 0.00016730520346788815 6.299971555125547e-06 3.246564373106108e-05 26.556501407021678 -2.0 -3.7764905515525613 -5.200661411416244 -4.488575981484403 0.1 0.0016730520346788817 6.299971555125547e-05 0.0003246564373106108 26.556501407021685 -1.0 -2.7764905515525613 -4.200661411416244 -3.488575981484403 1.0 0.016730520346788815 0.0006299971555125545 0.003246564373106111 26.55650140702169 0.0 -1.7764905515525613 -3.200661411416244 -2.4885759814844026 10.0 0.16730520346788816 0.006299971555125547 0.03246564373106111 26.55650140702168 1.0 -0.7764905515525613 -2.200661411416244 -1.4885759814844026 25.0 0.9103540034941288 0.026602213999957724 0.15561951039850072 34.22098639968747 1.3979400086720377 -0.0407896935383408 -1.5750822172053494 -0.807935955371845 50.0 0.9321970575151486 0.04244009910699548 0.1989033320691045 21.96500661237836 1.6989700043360187 -0.030492272254056346 -1.3722236105960741 -0.7013579414250652 75.0 0.9509849854317021 0.058336888142774906 0.2355366313773457 16.30160633704427 1.8750612633917 -0.021826339840331457 -1.2340567411118886 -0.6279415404761101 100.0 0.9698952487336788 0.07429279944768796 0.2684329212288177 13.055037041868566 2.0 -0.013275168160068709 -1.1290532765715249 -0.5711642223657968 250.0 1.082081428740545 0.17127212484355148 0.43050015743799575 6.317907422056988 2.3979400086720375 0.03425994350811681 -0.7663133142774791 -0.36602668538468114 500.0 1.1620407505236023 0.23953257751083248 0.5275856481610742 4.851284792236876 2.6989700043360187 0.06522135818961226 -0.6206354122242267 -0.27770702701730715 1000.0 1.1620407505236023 0.23953257751083248 0.5275856481610742 4.851284792236876 3.0 0.06522135818961226 -0.6206354122242267 -0.27770702701730715 2500.0 1.1620407505236023 0.23953257751083248 0.5275856481610742 4.851284792236876 3.3979400086720375 0.06522135818961226 -0.6206354122242267 -0.27770702701730715 5000.0 1.1620407505236023 0.23953257751083248 0.5275856481610742 4.851284792236876 3.6989700043360187 0.06522135818961226 -0.6206354122242267 -0.27770702701730715 10000.0 1.1620407505236023 0.23953257751083248 0.5275856481610742 4.851284792236876 4.0 0.06522135818961226 -0.6206354122242267 -0.27770702701730715 ==> haloperidol_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 2.026315042487646e-09 1.070560861059311e-09 1.4728521910439654e-09 1.89276024950382 -6.0 -8.693293031543744 -8.970388638158527 -8.831840834851135 5e-06 1.0131575212438228e-08 5.352804305296556e-09 7.364260955219827e-09 1.8927602495038194 -5.301029995663981 -7.9943230272077255 -8.271418633822508 -8.132870830515117 1e-05 2.0263150424876457e-08 1.0705608610593113e-08 1.4728521910439655e-08 1.8927602495038194 -5.0 -7.693293031543744 -7.970388638158527 -7.8318408348511355 5e-05 1.013157521243823e-07 5.3528043052965564e-08 7.364260955219827e-08 1.8927602495038196 -4.301029995663981 -6.9943230272077255 -7.271418633822508 -7.132870830515117 0.0001 2.026315042487646e-07 1.0705608610593113e-07 1.4728521910439656e-07 1.8927602495038196 -4.0 -6.693293031543744 -6.970388638158527 -6.8318408348511355 0.001 2.0263150424876455e-06 1.070560861059311e-06 1.4728521910439655e-06 1.8927602495038198 -3.0 -5.693293031543744 -5.970388638158527 -5.8318408348511355 0.01 2.0263150424876455e-05 1.070560861059311e-05 1.4728521910439654e-05 1.8927602495038196 -2.0 -4.693293031543744 -4.970388638158527 -4.8318408348511355 0.1 0.0002026315042487646 0.00010705608610593111 0.00014728521910439656 1.8927602495038198 -1.0 -3.693293031543744 -3.970388638158527 -3.8318408348511355 1.0 0.0020263150424876457 0.0010705608610593112 0.0014728521910439656 1.8927602495038194 0.0 -2.693293031543744 -2.9703886381585267 -2.8318408348511355 10.0 0.020263150424876458 0.010705608610593111 0.014728521910439654 1.8927602495038198 1.0 -1.6932930315437442 -1.970388638158527 -1.8318408348511355 25.0 0.08536443747895182 0.04533753085188046 0.06221103453452127 1.8828647232210522 1.3979400086720377 -1.068723017171548 -1.3435421358769764 -1.2061325765242623 50.0 0.13547188592109066 0.07265193774755258 0.09920834149648218 1.864669960928252 1.6989700043360187 -0.8681508232853481 -1.1387527978580931 -1.0034518105717205 75.0 0.1848622822366561 0.10034227809456606 0.1361965584491279 1.8423169749289072 1.8750612633917 -0.7331516896383323 -0.9985160433055932 -0.8658338664719627 100.0 0.23377079027406383 0.12841610694388989 0.17326261802302262 1.8204164246795584 2.0 -0.6312097550017879 -0.8913805002691908 -0.7612951276354893 250.0 0.5119916624330996 0.30533694585625176 0.39538585016561695 1.6768087497480173 2.3979400086720375 -0.2907371112678803 -0.5152206427674622 -0.4029788770176712 500.0 0.6969212041522749 0.43662770947055135 0.5516295034264087 1.596145157615745 2.6989700043360187 -0.15681632166716872 -0.359888706354106 -0.2583525140106374 1000.0 0.6969212041522749 0.43662770947055135 0.5516295034264087 1.596145157615745 3.0 -0.15681632166716872 -0.359888706354106 -0.2583525140106374 2500.0 0.6969212041522749 0.43662770947055135 0.5516295034264087 1.596145157615745 3.3979400086720375 -0.15681632166716872 -0.359888706354106 -0.2583525140106374 5000.0 0.6969212041522749 0.43662770947055135 0.5516295034264087 1.596145157615745 3.6989700043360187 -0.15681632166716872 -0.359888706354106 -0.2583525140106374 10000.0 0.6969212041522749 0.43662770947055135 0.5516295034264087 1.596145157615745 4.0 -0.15681632166716872 -0.359888706354106 -0.2583525140106374 ==> haloperidol_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 2.6992690223409692e-09 9.082283026943221e-10 1.5657434408855463e-09 2.9720159725626263 -6.0 -8.568753829376114 -9.041804968508114 -8.805279398942114 5e-06 1.3496345111704847e-08 4.541141513471612e-09 7.82871720442773e-09 2.972015972562626 -5.301029995663981 -7.869783825040096 -8.342834964172095 -8.106309394606095 1e-05 2.6992690223409694e-08 9.082283026943224e-09 1.5657434408855463e-08 2.972015972562626 -5.0 -7.5687538293761145 -8.041804968508114 -7.805279398942114 5e-05 1.3496345111704845e-07 4.54114151347161e-08 7.828717204427715e-08 2.9720159725626263 -4.301029995663981 -6.869783825040096 -7.342834964172096 -7.106309394606096 0.0001 2.699269022340969e-07 9.08228302694322e-08 1.565743440885543e-07 2.9720159725626263 -4.0 -6.5687538293761145 -7.0418049685081145 -6.8052793989421145 0.001 2.6992690223409695e-06 9.082283026943221e-07 1.565743440885543e-06 2.9720159725626267 -3.0 -5.5687538293761145 -6.0418049685081145 -5.8052793989421145 0.01 2.699269022340969e-05 9.082283026943221e-06 1.565743440885543e-05 2.972015972562626 -2.0 -4.5687538293761145 -5.0418049685081145 -4.8052793989421145 0.1 0.0002699269022340969 9.082283026943222e-05 0.0001565743440885543 2.9720159725626263 -1.0 -3.5687538293761145 -4.0418049685081145 -3.8052793989421145 1.0 0.002699269022340969 0.0009082283026943223 0.001565743440885543 2.972015972562626 0.0 -2.5687538293761145 -3.0418049685081145 -2.8052793989421145 10.0 0.026992690223409693 0.009082283026943222 0.01565743440885543 2.9720159725626263 1.0 -1.5687538293761145 -2.0418049685081145 -1.8052793989421145 25.0 0.11342335840560894 0.038440363117671086 0.06603056173573989 2.950631815272007 1.3979400086720377 -0.9452974976298959 -1.4152125185254487 -1.1802550080776724 50.0 0.17820334044241895 0.06154963517391675 0.10472989349275674 2.8952785818938085 1.6989700043360187 -0.7490841593220818 -1.2107745169393973 -0.9799293381307396 75.0 0.24157030971145566 0.08494367883937463 0.14324758568736212 2.8438880092332264 1.8750612633917 -0.6169564438954405 -1.0708689340088406 -0.8439126889521406 100.0 0.30298991609769566 0.10863638243789864 0.1814269230296763 2.7890280336874995 2.0 -0.518571825147866 -0.9640247047113705 -0.7412982649296183 250.0 0.625802584131467 0.2579563535210077 0.4017832159592744 2.4260018239112777 2.3979400086720375 -0.20356264785054848 -0.5884537708915336 -0.39600820937104103 500.0 0.8235442693546381 0.36974669200914273 0.5518176957265541 2.2273201820403963 2.6989700043360187 -0.08431305050796638 -0.43209570279043985 -0.2582043766492031 1000.0 0.8235442693546381 0.36974669200914273 0.5518176957265541 2.2273201820403963 3.0 -0.08431305050796638 -0.43209570279043985 -0.2582043766492031 2500.0 0.8235442693546381 0.36974669200914273 0.5518176957265541 2.2273201820403963 3.3979400086720375 -0.08431305050796638 -0.43209570279043985 -0.2582043766492031 5000.0 0.8235442693546381 0.36974669200914273 0.5518176957265541 2.2273201820403963 3.6989700043360187 -0.08431305050796638 -0.43209570279043985 -0.2582043766492031 10000.0 0.8235442693546381 0.36974669200914273 0.5518176957265541 2.2273201820403963 4.0 -0.08431305050796638 -0.43209570279043985 -0.2582043766492031 ==> imipramine_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 3.872796206228413e-09 3.5828236812206503e-10 1.1779450734315534e-09 10.809340762504313 -6.0 -8.411975355799637 -9.445774563912341 -8.928874959855989 5e-06 1.9363981031142067e-08 1.791411840610326e-09 5.889725367157766e-09 10.80934076250431 -5.301029995663981 -7.713005351463619 -8.746804559576322 -8.22990495551997 1e-05 3.8727962062284135e-08 3.582823681220652e-09 1.1779450734315534e-08 10.80934076250431 -5.0 -7.411975355799638 -8.445774563912341 -7.928874959855989 5e-05 1.9363981031142067e-07 1.7914118406103258e-08 5.889725367157766e-08 10.80934076250431 -4.301029995663981 -6.713005351463619 -7.746804559576322 -7.22990495551997 0.0001 3.8727962062284133e-07 3.5828236812206517e-08 1.1779450734315534e-07 10.80934076250431 -4.0 -6.411975355799638 -7.445774563912341 -6.928874959855989 0.001 3.872796206228414e-06 3.5828236812206514e-07 1.1779450734315534e-06 10.809340762504311 -3.0 -5.411975355799638 -6.445774563912341 -5.928874959855989 0.01 3.872796206228414e-05 3.582823681220652e-06 1.1779450734315535e-05 10.80934076250431 -2.0 -4.411975355799638 -5.445774563912341 -4.928874959855989 0.1 0.0003872796206228414 3.582823681220651e-05 0.00011779450734315534 10.809340762504313 -1.0 -3.4119753557996373 -4.445774563912341 -3.928874959855989 1.0 0.0038727962062284137 0.0003582823681220651 0.0011779450734315535 10.809340762504313 0.0 -2.4119753557996373 -3.445774563912341 -2.928874959855989 10.0 0.038727962062284134 0.0035828236812206512 0.011779450734315522 10.809340762504311 1.0 -1.4119753557996375 -2.445774563912341 -1.9288749598559893 25.0 0.09681990515571033 0.008957059203051624 0.029448626835788812 10.809340762504315 1.3979400086720377 -1.0140353471275998 -2.0478345552403034 -1.5309349511839516 50.0 0.19363981031142066 0.017914118406103248 0.0588972536715776 10.809340762504315 1.6989700043360187 -0.7130053514636187 -1.7468045595763224 -1.2299049555199706 75.0 0.290459715467131 0.02687117760915488 0.08834588050736643 10.809340762504313 1.8750612633917 -0.5369140924079374 -1.570713300520641 -1.0538136964642892 100.0 0.3872796206228413 0.035828236812206496 0.11779450734315522 10.809340762504315 2.0 -0.4119753557996375 -1.4457745639123412 -0.9288749598559893 250.0 0.9681990515571033 0.08957059203051626 0.2944862683578881 10.809340762504313 2.3979400086720375 -0.014035347127599898 -1.0478345552403034 -0.5309349511839516 500.0 1.9363981031142066 0.17914118406103252 0.5889725367157761 10.809340762504313 2.6989700043360187 0.2869946485363813 -0.7468045595763223 -0.22990495551997056 1000.0 3.872796206228413 0.35828236812206504 1.1779450734315524 10.809340762504313 3.0 0.5880246442003625 -0.44577456391234105 0.07112504014401075 2500.0 9.162377094271548 1.5263018411156386 3.739592628613767 6.002991575751739 3.3979400086720375 0.9620081619861377 0.1836404280933824 0.5728242950397601 5000.0 10.88669196514182 2.4403257919210612 5.154325871657259 4.461163341871518 3.6989700043360187 1.0368959348948934 0.3874478100225277 0.7121718724587105 10000.0 14.33139858455281 4.305787289135899 7.8554410354166455 3.3284037557342705 4.0 1.1562885747598837 0.6340525713684947 0.8951705730641892 ==> imipramine_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.0649432695314193e-09 3.5538958506118656e-10 6.151989488551441e-10 2.996551711970036 -6.0 -8.97267352685969 -9.44929530364589 -9.21098441525279 5e-06 5.324716347657097e-09 1.7769479253059333e-09 3.07599474427572e-09 2.9965517119700356 -5.301029995663981 -8.273703522523672 -8.750325299309871 -8.512014410916771 1e-05 1.0649432695314194e-08 3.5538958506118666e-09 6.151989488551441e-09 2.9965517119700356 -5.0 -7.9726735268596896 -8.44929530364589 -8.21098441525279 5e-05 5.324716347657096e-08 1.776947925305933e-08 3.07599474427572e-08 2.996551711970035 -4.301029995663981 -7.273703522523671 -7.750325299309871 -7.5120144109167715 0.0001 1.0649432695314192e-07 3.553895850611866e-08 6.15198948855144e-08 2.996551711970035 -4.0 -6.97267352685969 -7.44929530364589 -7.21098441525279 0.001 1.0649432695314195e-06 3.553895850611866e-07 6.151989488551441e-07 2.9965517119700364 -3.0 -5.9726735268596896 -6.44929530364589 -6.21098441525279 0.01 1.0649432695314194e-05 3.5538958506118656e-06 6.151989488551441e-06 2.996551711970036 -2.0 -4.9726735268596896 -5.44929530364589 -5.21098441525279 0.1 0.00010649432695314194 3.5538958506118664e-05 6.151989488551441e-05 2.9965517119700356 -1.0 -3.97267352685969 -4.44929530364589 -4.21098441525279 1.0 0.0010649432695314194 0.0003553895850611866 0.000615198948855144 2.9965517119700356 0.0 -2.97267352685969 -3.44929530364589 -3.21098441525279 10.0 0.010649432695314192 0.003553895850611867 0.006151989488551441 2.9965517119700347 1.0 -1.97267352685969 -2.44929530364589 -2.21098441525279 25.0 0.026623581738285478 0.008884739626529666 0.015379973721378606 2.9965517119700347 1.3979400086720377 -1.5747335181876525 -2.0513552949738525 -1.8130444065807525 50.0 0.053247163476570956 0.01776947925305933 0.030759947442757216 2.9965517119700347 1.6989700043360187 -1.2737035225236712 -1.7503252993098712 -1.5120144109167712 75.0 0.07987074521485645 0.026654218879589003 0.04613992116413584 2.9965517119700347 1.8750612633917 -1.09761226346799 -1.57423404025419 -1.33592315186109 100.0 0.10649432695314191 0.03553895850611866 0.06151989488551444 2.9965517119700347 2.0 -0.97267352685969 -1.44929530364589 -1.21098441525279 250.0 0.2662358173828548 0.08884739626529665 0.15379973721378606 2.996551711970035 2.3979400086720375 -0.5747335181876525 -1.0513552949738525 -0.8130444065807525 500.0 0.5324716347657096 0.1776947925305933 0.30759947442757213 2.996551711970035 2.6989700043360187 -0.27370352252367125 -0.7503252993098712 -0.5120144109167712 1000.0 1.0649432695314192 0.3553895850611866 0.6151989488551443 2.996551711970035 3.0 0.027326473140309955 -0.44929530364589004 -0.2109844152527901 2500.0 4.491119292886736 1.5139902640702183 2.6075871767226575 2.9664122679447025 3.3979400086720375 0.6523545909242978 0.1801230823805826 0.4162388366524402 5000.0 7.024536221750239 2.4206730781598007 4.123603487066763 2.9018938100845495 3.6989700043360187 0.8466176562662893 0.38393614014875665 0.615276898207523 10000.0 11.73219051491369 4.271254121555921 7.078924147898773 2.746778857222365 4.0 1.0693791067210565 0.6305554108804229 0.8499672588007396 ==> imipramine_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.4380124971435123e-08 2.3120686679960058e-10 1.8233989247644688e-09 62.19592510588861 -6.0 -7.842237339671576 -9.635999271597145 -8.73911830563436 5e-06 7.190062485717563e-08 1.1560343339980034e-09 9.116994623822343e-09 62.1959251058886 -5.301029995663981 -7.143267335335557 -8.937029267261126 -8.040148301298341 1e-05 1.4380124971435125e-07 2.312068667996007e-09 1.823398924764469e-08 62.1959251058886 -5.0 -6.842237339671576 -8.635999271597145 -7.73911830563436 5e-05 7.190062485717562e-07 1.1560343339980037e-08 9.116994623822343e-08 62.19592510588858 -4.301029995663981 -6.143267335335557 -7.937029267261126 -7.040148301298341 0.0001 1.4380124971435123e-06 2.3120686679960074e-08 1.8233989247644688e-07 62.19592510588858 -4.0 -5.842237339671576 -7.635999271597145 -6.73911830563436 0.001 1.4380124971435125e-05 2.312068667996007e-07 1.8233989247644687e-06 62.19592510588859 -3.0 -4.842237339671576 -6.635999271597145 -5.73911830563436 0.01 0.00014380124971435124 2.312068667996007e-06 1.8233989247644687e-05 62.195925105888584 -2.0 -3.842237339671576 -5.635999271597145 -4.73911830563436 0.1 0.0014380124971435126 2.312068667996007e-05 0.0001823398924764467 62.19592510588859 -1.0 -2.842237339671576 -4.635999271597145 -3.7391183056343604 1.0 0.014380124971435123 0.00023120686679960068 0.001823398924764467 62.19592510588859 0.0 -1.8422373396715763 -3.6359992715971448 -2.7391183056343604 10.0 0.14380124971435124 0.0023120686679960066 0.01823398924764467 62.1959251058886 1.0 -0.8422373396715763 -2.6359992715971448 -1.7391183056343604 25.0 0.3595031242858781 0.005780171669990016 0.04558497311911166 62.195925105888605 1.3979400086720377 -0.44429733099953866 -2.2380592629251073 -1.341178296962323 50.0 0.7190062485717562 0.011560343339980033 0.09116994623822333 62.195925105888605 1.6989700043360187 -0.14326733533555747 -1.937029267261126 -1.0401483012983417 75.0 1.0785093728576343 0.017340515009970053 0.136754919357335 62.195925105888584 1.8750612633917 0.03282392372012374 -1.7609380082054447 -0.8640570422426604 100.0 1.4380124971435124 0.023120686679960065 0.18233989247644666 62.195925105888605 2.0 0.1577626603284237 -1.6359992715971448 -0.7391183056343605 250.0 3.5950312428587807 0.05780171669990016 0.45584973119111655 62.1959251058886 2.3979400086720375 0.5557026690004613 -1.2380592629251073 -0.341178296962323 500.0 7.1900624857175615 0.11560343339980032 0.911699462382233 62.1959251058886 2.6989700043360187 0.8567326646644424 -0.9370292672611261 -0.040148301298341856 1000.0 14.380124971435123 0.23120686679960065 1.8233989247644662 62.1959251058886 3.0 1.1577626603284237 -0.6359992715971449 0.2608816943656394 2500.0 38.60311815891225 0.9831865992478964 6.1606873368988335 39.263267205271404 3.3979400086720375 1.5866223861358801 -0.007364049479163303 0.7896291683283584 5000.0 39.44382652236968 1.5676745923416788 7.863528766644895 25.160723223466515 3.6989700043360187 1.5959790400657856 0.19525591968975242 0.895617479877769 10000.0 41.10411002093938 2.749742533160735 10.631355492706252 14.948348627277337 4.0 1.6138852493741715 0.4392920314076226 1.026588640390897 ==> imipramine_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.0575663005132434e-09 2.733932504166522e-10 5.377094832978394e-10 3.868297036966015 -6.0 -8.975692396487709 -9.563212211578684 -9.269452304033196 5e-06 5.287831502566218e-09 1.366966252083261e-09 2.6885474164891968e-09 3.8682970369660157 -5.301029995663981 -8.27672239215169 -8.864242207242665 -8.570482299697177 1e-05 1.0575663005132436e-08 2.733932504166522e-09 5.377094832978394e-09 3.8682970369660157 -5.0 -7.975692396487709 -8.563212211578684 -8.269452304033196 5e-05 5.287831502566217e-08 1.3669662520832611e-08 2.6885474164891968e-08 3.868297036966015 -4.301029995663981 -7.27672239215169 -7.864242207242665 -7.5704822996971775 0.0001 1.0575663005132434e-07 2.7339325041665222e-08 5.377094832978394e-08 3.868297036966015 -4.0 -6.975692396487709 -7.5632122115786835 -7.269452304033196 0.001 1.0575663005132435e-06 2.733932504166522e-07 5.377094832978395e-07 3.8682970369660152 -3.0 -5.975692396487709 -6.5632122115786835 -6.269452304033196 0.01 1.0575663005132435e-05 2.733932504166522e-06 5.377094832978395e-06 3.8682970369660152 -2.0 -4.975692396487709 -5.5632122115786835 -5.269452304033196 0.1 0.00010575663005132433 2.7339325041665218e-05 5.3770948329783945e-05 3.868297036966015 -1.0 -3.975692396487709 -4.5632122115786835 -4.269452304033196 1.0 0.0010575663005132434 0.00027339325041665223 0.0005377094832978394 3.8682970369660143 0.0 -2.975692396487709 -3.5632122115786835 -3.269452304033196 10.0 0.010575663005132435 0.0027339325041665224 0.005377094832978394 3.868297036966015 1.0 -1.9756923964877087 -2.5632122115786835 -2.269452304033196 25.0 0.026439157512831088 0.006834831260416305 0.013442737082445982 3.8682970369660152 1.3979400086720377 -1.5777523878156712 -2.165272202906646 -1.8715122953611587 50.0 0.052878315025662176 0.01366966252083261 0.02688547416489198 3.8682970369660152 1.6989700043360187 -1.27672239215169 -1.8642422072426645 -1.5704822996971772 75.0 0.07931747253849326 0.02050449378124892 0.040328211247337965 3.868297036966015 1.8750612633917 -1.1006311330960088 -1.6881509481869834 -1.394391040641496 100.0 0.10575663005132435 0.02733932504166522 0.05377094832978394 3.8682970369660152 2.0 -0.9756923964877087 -1.5632122115786835 -1.2694523040331962 250.0 0.26439157512831085 0.06834831260416305 0.1344273708244599 3.868297036966015 2.3979400086720375 -0.5777523878156712 -1.1652722029066458 -0.8715122953611585 500.0 0.5287831502566217 0.1366966252083261 0.2688547416489198 3.868297036966015 2.6989700043360187 -0.2767223921516899 -0.8642422072426647 -0.5704822996971772 1000.0 1.0575663005132434 0.2733932504166522 0.5377094832978395 3.868297036966015 3.0 0.024307603512291234 -0.5632122115786835 -0.26945230403319614 2500.0 4.464198828255119 1.1667338375551484 2.2822208110740054 3.8262358427948726 3.3979400086720375 0.6497435291398876 0.06697179343614716 0.3583576612880173 5000.0 7.048987301927044 1.8706200202535928 3.6312500285023184 3.7682625148914206 3.6989700043360187 0.8481267282288221 0.27198557805769685 0.5600561531432595 10000.0 12.005688622994375 3.321497286428673 6.314812917496718 3.614541150477074 4.0 1.0793870753959205 0.521333901971145 0.8003604886835327 ==> imipramine_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.6588177535057837e-09 2.72996401229839e-10 6.729422538399905e-10 6.076335607476397 -6.0 -8.780201325244157 -9.563843078000724 -9.17202220162244 5e-06 8.294088767528917e-09 1.364982006149195e-09 3.3647112691999523e-09 6.076335607476396 -5.301029995663981 -8.081231320908138 -8.864873073664706 -8.473052197286421 1e-05 1.6588177535057835e-08 2.72996401229839e-09 6.729422538399905e-09 6.076335607476396 -5.0 -7.780201325244156 -8.563843078000724 -8.17202220162244 5e-05 8.294088767528917e-08 1.3649820061491947e-08 3.364711269199952e-08 6.076335607476397 -4.301029995663981 -7.081231320908137 -7.864873073664706 -7.473052197286421 0.0001 1.6588177535057834e-07 2.7299640122983894e-08 6.729422538399905e-08 6.076335607476397 -4.0 -6.780201325244156 -7.563843078000724 -7.17202220162244 0.001 1.6588177535057837e-06 2.7299640122983894e-07 6.729422538399905e-07 6.0763356074763974 -3.0 -5.780201325244156 -6.563843078000724 -6.17202220162244 0.01 1.6588177535057833e-05 2.7299640122983902e-06 6.729422538399905e-06 6.076335607476394 -2.0 -4.780201325244156 -5.563843078000724 -5.17202220162244 0.1 0.00016588177535057833 2.7299640122983896e-05 6.729422538399891e-05 6.076335607476396 -1.0 -3.7802013252441564 -4.563843078000724 -4.172022201622441 1.0 0.0016588177535057835 0.00027299640122983897 0.0006729422538399891 6.076335607476396 0.0 -2.7802013252441564 -3.5638430780007244 -3.1720222016224406 10.0 0.016588177535057834 0.00272996401229839 0.006729422538399891 6.076335607476396 1.0 -1.7802013252441564 -2.5638430780007244 -2.1720222016224406 25.0 0.04147044383764459 0.006824910030745974 0.016823556345999743 6.076335607476396 1.3979400086720377 -1.3822613165721187 -2.165903069328687 -1.7740821929504027 50.0 0.08294088767528918 0.013649820061491949 0.033647112691999485 6.076335607476396 1.6989700043360187 -1.0812313209081374 -1.8648730736647054 -1.4730521972864214 75.0 0.12441133151293376 0.02047473009223792 0.05047066903799922 6.0763356074763974 1.8750612633917 -0.9051400618524563 -1.6887818146090243 -1.2969609382307403 100.0 0.16588177535057835 0.027299640122983897 0.06729422538399894 6.076335607476396 2.0 -0.7802013252441563 -1.5638430780007244 -1.1720222016224404 250.0 0.4147044383764459 0.06824910030745975 0.1682355634599974 6.076335607476396 2.3979400086720375 -0.3822613165721187 -1.1659030693286867 -0.7740821929504027 500.0 0.8294088767528918 0.1364982006149195 0.3364711269199948 6.076335607476396 2.6989700043360187 -0.08123132090813752 -0.8648730736647056 -0.47305219728642156 1000.0 1.6588177535057835 0.272996401229839 0.6729422538399895 6.076335607476396 3.0 0.21979867475584364 -0.5638430780007244 -0.1720222016224404 2500.0 6.977590711598896 1.1618359803227074 2.8472470817793667 6.005658999870899 3.3979400086720375 0.8437054912073565 0.0651448217990571 0.4544251565032068 5000.0 10.799896524311999 1.8548560842000443 4.475740584177219 5.822498368637445 3.6989700043360187 1.0334195944558764 0.2683102189308848 0.6508649066933806 10000.0 17.680654490546626 3.262587843715054 7.595043673987886 5.419211784475345 4.0 1.2474983373949198 0.5135622136879855 0.8805302755414526 ==> indomethacin_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 8.219804658532813e-08 1.0197415868237809e-10 2.8951816257143147e-09 806.0674159749904 -6.0 -7.085138503229941 -9.99150986905679 -8.538324186143365 5e-06 4.1099023292664065e-07 5.098707934118904e-10 1.4475908128571572e-08 806.0674159749904 -5.301029995663981 -6.386168498893922 -9.292539864720771 -7.839354181807346 1e-05 8.219804658532813e-07 1.0197415868237808e-09 2.8951816257143147e-08 806.0674159749904 -5.0 -6.085138503229941 -8.99150986905679 -7.538324186143365 5e-05 4.109902329266407e-06 5.098707934118904e-09 1.447590812857157e-07 806.0674159749905 -4.301029995663981 -5.386168498893922 -8.292539864720771 -6.839354181807346 0.0001 8.219804658532814e-06 1.0197415868237808e-08 2.895181625714309e-07 806.0674159749905 -4.0 -5.085138503229941 -7.991509869056791 -6.538324186143366 0.001 8.219804658532813e-05 1.0197415868237811e-07 2.895181625714309e-06 806.0674159749901 -3.0 -4.085138503229941 -6.991509869056791 -5.538324186143366 0.01 0.0008219804658532813 1.019741586823781e-06 2.895181625714309e-05 806.0674159749902 -2.0 -3.0851385032299405 -5.991509869056791 -4.538324186143366 0.1 0.008219804658532812 1.0197415868237812e-05 0.0002895181625714309 806.06741597499 -1.0 -2.085138503229941 -4.991509869056791 -3.538324186143366 1.0 0.08219804658532813 0.00010197415868237808 0.0028951816257143086 806.0674159749904 0.0 -1.0851385032299408 -3.9915098690567907 -2.538324186143366 10.0 1.0429547988617613 0.0016354600865028928 0.04130025357749105 637.7133917660525 1.0 0.018265486729218367 -2.7863600503913792 -1.3840472818310805 25.0 1.8670171005533083 0.003648208498820287 0.08253040441971304 511.76271892273735 1.3979400086720377 0.27114829579692384 -2.437920349263694 -1.083386026733385 50.0 2.821454827001165 0.008245468783923708 0.15252612137364857 342.18246420412027 1.6989700043360187 0.45047310137509267 -2.0837846481475704 -0.8166557733862388 75.0 3.427113452154329 0.015027951193022943 0.2269416085514678 228.049280180351 1.8750612633917 0.5349284816779045 -1.8231002240847798 -0.6440858712034376 100.0 3.862578726980168 0.025032616862340165 0.31095088578925156 154.30183541023032 2.0 0.5868773443020495 -1.6014937476962527 -0.5073082016971016 250.0 4.332333030604022 0.04809150589925779 0.45645199035478284 90.08520214940667 2.3979400086720375 0.6367218338707428 -1.317931623560454 -0.34060489484485557 500.0 4.332333030604022 0.04809150589925779 0.45645199035478284 90.08520214940667 2.6989700043360187 0.6367218338707428 -1.317931623560454 -0.34060489484485557 1000.0 4.332333030604022 0.04809150589925779 0.45645199035478284 90.08520214940667 3.0 0.6367218338707428 -1.317931623560454 -0.34060489484485557 2500.0 4.332333030604022 0.04809150589925779 0.45645199035478284 90.08520214940667 3.3979400086720375 0.6367218338707428 -1.317931623560454 -0.34060489484485557 5000.0 4.332333030604022 0.04809150589925779 0.45645199035478284 90.08520214940667 3.6989700043360187 0.6367218338707428 -1.317931623560454 -0.34060489484485557 10000.0 4.332333030604022 0.04809150589925779 0.45645199035478284 90.08520214940667 4.0 0.6367218338707428 -1.317931623560454 -0.34060489484485557 ==> indomethacin_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 7.697729321962728e-08 1.0083931112944811e-10 2.7860971305531997e-09 763.3659170956752 -6.0 -7.1136373642267134 -9.996370129811352 -8.555003747019033 5e-06 3.8488646609813644e-07 5.041965556472406e-10 1.3930485652765997e-08 763.3659170956751 -5.301029995663981 -6.414667359890695 -9.297400125475333 -7.856033742683014 1e-05 7.697729321962729e-07 1.0083931112944813e-09 2.7860971305531998e-08 763.3659170956751 -5.0 -6.1136373642267134 -8.996370129811352 -7.5550037470190325 5e-05 3.8488646609813646e-06 5.041965556472407e-09 1.3930485652765996e-07 763.365917095675 -4.301029995663981 -5.414667359890695 -8.297400125475333 -6.856033742683014 0.0001 7.697729321962729e-06 1.0083931112944815e-08 2.7860971305532e-07 763.365917095675 -4.0 -5.1136373642267134 -7.9963701298113525 -6.5550037470190325 0.001 7.69772932196273e-05 1.0083931112944812e-07 2.7860971305531996e-06 763.3659170956752 -3.0 -4.1136373642267134 -6.9963701298113525 -5.5550037470190325 0.01 0.0007697729321962729 1.0083931112944814e-06 2.786097130553194e-05 763.3659170956751 -2.0 -3.113637364226714 -5.9963701298113525 -4.555003747019033 0.1 0.0076977293219627286 1.0083931112944811e-05 0.0002786097130553194 763.3659170956752 -1.0 -2.113637364226714 -4.9963701298113525 -3.5550037470190334 1.0 0.07697729321962729 0.00010083931112944813 0.0027860971305531967 763.3659170956751 0.0 -1.1136373642267139 -3.996370129811352 -2.555003747019033 10.0 1.0730554421631449 0.001617259417813036 0.0416582407174604 663.5023610585621 1.0 0.030622161484568255 -2.791220311146 -1.380299074830716 25.0 1.9224613633875771 0.0036076084042381885 0.08327957595581421 532.8908096369565 1.3979400086720377 0.2838576203402109 -2.4427806100182203 -1.0794614948390047 50.0 2.8474162653706205 0.008153706810175122 0.1523712485817316 349.217396659062 1.6989700043360187 0.4544509615405383 -2.088644908902054 -0.8170969736807578 75.0 3.4424828175354594 0.014860708492940983 0.22618075436109192 231.64997948588254 1.8750612633917 0.5368717812403168 -1.8279604848392483 -0.6455443517994658 100.0 3.8731476784237273 0.02475403448072369 0.309638549248371 156.4653099857238 2.0 0.5880640564236745 -1.6063540084507135 -0.5091449760135196 250.0 4.337676498438506 0.04755630631055342 0.45418484368793105 91.2113836199241 2.3979400086720375 0.6372571594389094 -1.3227918843149078 -0.3427673624379992 500.0 4.337676498438506 0.04755630631055342 0.45418484368793105 91.2113836199241 2.6989700043360187 0.6372571594389094 -1.3227918843149078 -0.3427673624379992 1000.0 4.337676498438506 0.04755630631055342 0.45418484368793105 91.2113836199241 3.0 0.6372571594389094 -1.3227918843149078 -0.3427673624379992 2500.0 4.337676498438506 0.04755630631055342 0.45418484368793105 91.2113836199241 3.3979400086720375 0.6372571594389094 -1.3227918843149078 -0.3427673624379992 5000.0 4.337676498438506 0.04755630631055342 0.45418484368793105 91.2113836199241 3.6989700043360187 0.6372571594389094 -1.3227918843149078 -0.3427673624379992 10000.0 4.337676498438506 0.04755630631055342 0.45418484368793105 91.2113836199241 4.0 0.6372571594389094 -1.3227918843149078 -0.3427673624379992 ==> indomethacin_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.4475123773828698e-07 5.419226537640943e-10 8.856860329189461e-09 267.10682185524394 -6.0 -6.839377714021183 -9.266062693979116 -8.052720204000149 5e-06 7.237561886914351e-07 2.7096132688204706e-09 4.428430164594731e-08 267.1068218552441 -5.301029995663981 -6.140407709685165 -8.567092689643097 -7.35375019966413 1e-05 1.4475123773828701e-06 5.419226537640941e-09 8.856860329189463e-08 267.1068218552441 -5.0 -5.839377714021183 -8.266062693979116 -7.052720204000149 5e-05 7.237561886914349e-06 2.709613268820471e-08 4.428430164594721e-07 267.106821855244 -4.301029995663981 -5.140407709685165 -7.567092689643098 -6.353750199664131 0.0001 1.4475123773828698e-05 5.419226537640942e-08 8.856860329189444e-07 267.106821855244 -4.0 -4.839377714021183 -7.266062693979117 -6.05272020400015 0.001 0.00014475123773828702 5.419226537640942e-07 8.856860329189443e-06 267.10682185524405 -3.0 -3.8393777140211833 -6.266062693979117 -5.05272020400015 0.01 0.0014475123773828704 5.419226537640944e-06 8.856860329189463e-05 267.106821855244 -2.0 -2.8393777140211833 -5.266062693979116 -4.052720204000149 0.1 0.014475123773828702 5.4192265376409425e-05 0.0008856860329189444 267.10682185524405 -1.0 -1.8393777140211833 -4.266062693979117 -3.05272020400015 1.0 0.144751237738287 0.0005419226537640943 0.008856860329189444 267.10682185524394 0.0 -0.8393777140211834 -3.266062693979116 -2.05272020400015 10.0 1.8655022065110511 0.008485699823207004 0.12581769249188723 219.84070204901747 1.0 0.2707957670595105 -2.07131233521736 -0.9002582840789248 25.0 2.8452837063585794 0.017933906683608454 0.22589168306563734 158.6538703783466 1.3979400086720377 0.4541255768692273 -1.7463250943573454 -0.6460997587440591 50.0 3.3871239618609668 0.03664242970052864 0.35229597167646765 92.43720980140411 1.6989700043360187 0.5298310912318842 -1.436015736681398 -0.45309232272475686 75.0 3.6681706144904176 0.05981257433031512 0.46840444867174974 61.32775015221606 1.8750612633917 0.5644495274365033 -1.2232075051720694 -0.32937898886778305 100.0 3.8944815805827564 0.08850488748699091 0.587095098011928 44.00301148515889 2.0 0.5904496541326101 -1.053032745686115 -0.2312915457767525 250.0 4.195854620654415 0.14191295600804787 0.7716515613909521 29.56639575893598 2.3979400086720375 0.622820432204704 -0.8479779536197088 -0.11257876070750242 500.0 4.195854620654415 0.14191295600804787 0.7716515613909521 29.56639575893598 2.6989700043360187 0.622820432204704 -0.8479779536197088 -0.11257876070750242 1000.0 4.195854620654415 0.14191295600804787 0.7716515613909521 29.56639575893598 3.0 0.622820432204704 -0.8479779536197088 -0.11257876070750242 2500.0 4.195854620654415 0.14191295600804787 0.7716515613909521 29.56639575893598 3.3979400086720375 0.622820432204704 -0.8479779536197088 -0.11257876070750242 5000.0 4.195854620654415 0.14191295600804787 0.7716515613909521 29.56639575893598 3.6989700043360187 0.622820432204704 -0.8479779536197088 -0.11257876070750242 10000.0 4.195854620654415 0.14191295600804787 0.7716515613909521 29.56639575893598 4.0 0.622820432204704 -0.8479779536197088 -0.11257876070750242 ==> indomethacin_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 8.93237402773414e-08 4.1280735774059175e-10 6.07235516150002e-09 216.38117296705855 -6.0 -7.049033099888547 -9.384252570591938 -8.216642835240243 5e-06 4.4661870138670703e-07 2.0640367887029587e-09 3.036177580750022e-08 216.38117296705857 -5.301029995663981 -6.350063095552527 -8.68528256625592 -7.517672830904223 1e-05 8.932374027734141e-07 4.128073577405917e-09 6.072355161500045e-08 216.38117296705857 -5.0 -6.049033099888546 -8.384252570591938 -7.216642835240242 5e-05 4.466187013867069e-06 2.0640367887029584e-08 3.036177580750022e-07 216.38117296705855 -4.301029995663981 -5.350063095552528 -7.6852825662559185 -6.517672830904223 0.0001 8.932374027734139e-06 4.128073577405917e-08 6.072355161500045e-07 216.38117296705855 -4.0 -5.049033099888547 -7.384252570591937 -6.216642835240242 0.001 8.93237402773414e-05 4.1280735774059177e-07 6.072355161500045e-06 216.38117296705855 -3.0 -4.049033099888547 -6.384252570591937 -5.216642835240242 0.01 0.0008932374027734142 4.128073577405917e-06 6.072355161500045e-05 216.3811729670586 -2.0 -3.0490330998885464 -5.384252570591937 -4.216642835240242 0.1 0.008932374027734141 4.128073577405917e-05 0.0006072355161500045 216.3811729670586 -1.0 -2.0490330998885464 -4.384252570591937 -3.2166428352402416 1.0 0.0893237402773414 0.0004128073577405918 0.006072355161500039 216.38117296705852 0.0 -1.0490330998885464 -3.3842525705919377 -2.216642835240242 10.0 1.3010400688868287 0.006463986216532256 0.09170553457911164 201.27519232007265 1.0 0.11429067198701122 -2.18949957829943 -1.0376044531562094 25.0 2.290375742055513 0.013661392481644798 0.17688901023709414 167.6531689674256 1.3979400086720377 0.35990673531601225 -1.8645050315276168 -0.7522991481058023 50.0 3.2518090049594477 0.027914162344238467 0.30128313009011076 116.49316088579054 1.6989700043360187 0.5121250293795602 -1.554175400044727 -0.5210251853325834 75.0 3.7330695891863597 0.04556906486834842 0.41244695448953433 81.92113663011095 1.8750612633917 0.5720660858057431 -1.3413298835677194 -0.38463189888098814 100.0 4.027629474761799 0.06743952307886317 0.5211731103158604 59.722093082596764 2.0 0.6050495104247826 -1.1710855096310957 -0.2830179996031565 250.0 4.325583597770397 0.10818944404214491 0.6840924532551139 39.9815678513458 2.3979400086720375 0.636044709764509 -0.965815110928971 -0.16488520058223102 500.0 4.325583597770397 0.10818944404214491 0.6840924532551139 39.9815678513458 2.6989700043360187 0.636044709764509 -0.965815110928971 -0.16488520058223102 1000.0 4.325583597770397 0.10818944404214491 0.6840924532551139 39.9815678513458 3.0 0.636044709764509 -0.965815110928971 -0.16488520058223102 2500.0 4.325583597770397 0.10818944404214491 0.6840924532551139 39.9815678513458 3.3979400086720375 0.636044709764509 -0.965815110928971 -0.16488520058223102 5000.0 4.325583597770397 0.10818944404214491 0.6840924532551139 39.9815678513458 3.6989700043360187 0.636044709764509 -0.965815110928971 -0.16488520058223102 10000.0 4.325583597770397 0.10818944404214491 0.6840924532551139 39.9815678513458 4.0 0.636044709764509 -0.965815110928971 -0.16488520058223102 ==> indomethacin_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.0610568305921373e-07 3.1053731749145e-10 5.7401893860574154e-09 341.684161878983 -6.0 -6.974261354504325 -9.507886202872953 -8.241073778688639 5e-06 5.305284152960686e-07 1.5526865874572502e-09 2.8700946930287074e-08 341.6841618789829 -5.301029995663981 -6.275291350168306 -8.808916198536934 -7.54210377435262 1e-05 1.0610568305921372e-06 3.1053731749145003e-09 5.7401893860574154e-08 341.6841618789829 -5.0 -5.974261354504325 -8.507886202872953 -7.241073778688639 5e-05 5.305284152960687e-06 1.5526865874572504e-08 2.870094693028707e-07 341.68416187898293 -4.301029995663981 -5.275291350168305 -7.808916198536934 -6.54210377435262 0.0001 1.0610568305921374e-05 3.105373174914501e-08 5.740189386057415e-07 341.68416187898293 -4.0 -4.974261354504325 -7.507886202872953 -6.241073778688639 0.001 0.00010610568305921373 3.105373174914501e-07 5.740189386057415e-06 341.6841618789829 -3.0 -3.9742613545043244 -6.507886202872953 -5.241073778688639 0.01 0.0010610568305921375 3.105373174914501e-06 5.7401893860574156e-05 341.68416187898293 -2.0 -2.9742613545043244 -5.507886202872953 -4.241073778688639 0.1 0.010610568305921372 3.1053731749145004e-05 0.0005740189386057416 341.6841618789829 -1.0 -1.9742613545043244 -4.507886202872953 -3.241073778688639 1.0 0.10610568305921374 0.00031053731749145007 0.005740189386057416 341.68416187898293 0.0 -0.9742613545043244 -3.507886202872953 -2.241073778688639 10.0 1.3940741974654864 0.004903731722347261 0.08268110948346849 284.28843101518356 1.0 0.1442858890362318 -2.3094732976028656 -1.082593704283317 25.0 2.4139489922415818 0.010560932282588092 0.15966700298021855 228.5734751108557 1.3979400086720377 0.3827280890330544 -1.9762977420946188 -0.7967848265307822 50.0 3.1665638624584673 0.02234290160590019 0.26598914415387104 141.7257220352373 1.6989700043360187 0.5005882511928446 -1.6508604270305478 -0.5751360879188516 75.0 3.5718047053696282 0.03786945339994824 0.36778022220303125 94.31888724790811 1.8750612633917 0.5528877050600174 -1.4217109633528855 -0.43441162914643405 100.0 3.873294282711929 0.05832788823923278 0.47531155681266646 66.40552914971907 2.0 0.5880804947920806 -1.2341237469138964 -0.3230216260609079 250.0 4.240918803959032 0.09940117754926046 0.6492706084556185 42.664673684145754 2.3979400086720375 0.6274599575976222 -1.0026084707322962 -0.18757425656733698 500.0 4.240918803959032 0.09940117754926046 0.6492706084556185 42.664673684145754 2.6989700043360187 0.6274599575976222 -1.0026084707322962 -0.18757425656733698 1000.0 4.240918803959032 0.09940117754926046 0.6492706084556185 42.664673684145754 3.0 0.6274599575976222 -1.0026084707322962 -0.18757425656733698 2500.0 4.240918803959032 0.09940117754926046 0.6492706084556185 42.664673684145754 3.3979400086720375 0.6274599575976222 -1.0026084707322962 -0.18757425656733698 5000.0 4.240918803959032 0.09940117754926046 0.6492706084556185 42.664673684145754 3.6989700043360187 0.6274599575976222 -1.0026084707322962 -0.18757425656733698 10000.0 4.240918803959032 0.09940117754926046 0.6492706084556185 42.664673684145754 4.0 0.6274599575976222 -1.0026084707322962 -0.18757425656733698 ==> ketoprofen_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 8.602563587126547e-08 2.9036769930369003e-11 1.5804766992612192e-09 2962.644814748933 -6.0 -7.065372108542997 -10.537051696492547 -8.801211902517771 5e-06 4.301281793563274e-07 1.4518384965184503e-10 7.902383496306096e-09 2962.644814748933 -5.301029995663981 -6.366402104206978 -9.838081692156527 -8.102241898181752 1e-05 8.602563587126548e-07 2.9036769930369005e-10 1.580476699261216e-08 2962.644814748933 -5.0 -6.065372108542997 -9.537051696492547 -7.801211902517772 5e-05 4.301281793563274e-06 1.4518384965184505e-09 7.902383496306095e-08 2962.6448147489327 -4.301029995663981 -5.366402104206978 -8.838081692156527 -7.102241898181752 0.0001 8.602563587126547e-06 2.903676993036901e-09 1.5804766992612193e-07 2962.6448147489327 -4.0 -5.065372108542997 -8.537051696492545 -6.801211902517771 0.001 8.602563587126545e-05 2.9036769930369008e-08 1.5804766992612193e-06 2962.644814748932 -3.0 -4.065372108542997 -7.537051696492546 -5.801211902517771 0.01 0.0008602563587126545 2.9036769930369005e-07 1.5804766992612193e-05 2962.6448147489323 -2.0 -3.065372108542997 -6.537051696492546 -4.801211902517771 0.1 0.008602563587126546 2.903676993036901e-06 0.00015804766992612177 2962.644814748932 -1.0 -2.065372108542997 -5.537051696492546 -3.8012119025177715 1.0 0.08602563587126548 2.9036769930369007e-05 0.0015804766992612177 2962.644814748933 0.0 -1.0653721085429966 -4.537051696492546 -2.8012119025177715 10.0 0.8602563587126547 0.0002903676993036901 0.015804766992612178 2962.6448147489327 1.0 -0.06537210854299658 -3.5370516964925462 -1.8012119025177715 25.0 2.1506408967816366 0.0007259192482592251 0.03951191748153045 2962.6448147489327 1.3979400086720377 0.332567900129041 -3.1391116878205088 -1.4032718938457338 50.0 4.301281793563273 0.0014518384965184503 0.07902383496306087 2962.6448147489327 1.6989700043360187 0.6335978957930222 -2.8380816921565275 -1.1022418981817528 75.0 6.451922690344909 0.002177757744777676 0.11853575244459134 2962.644814748932 1.8750612633917 0.8096891548487034 -2.661990433100846 -0.9261506391260714 100.0 8.602563587126546 0.0029036769930369005 0.15804766992612182 2962.6448147489327 2.0 0.9346278914570034 -2.5370516964925462 -0.8012119025177714 250.0 21.506408967816366 0.007259192482592251 0.3951191748153045 2962.6448147489327 2.3979400086720375 1.3325679001290411 -2.1391116878205088 -0.4032718938457338 500.0 43.01281793563273 0.014518384965184502 0.7902383496306089 2962.6448147489327 2.6989700043360187 1.6335978957930222 -1.8380816921565275 -0.10224189818175268 1000.0 86.02563587126546 0.029036769930369005 1.580476699261218 2962.6448147489327 3.0 1.9346278914570034 -1.5370516964925462 0.19878809748222856 2500.0 348.5360568706314 0.11994896412422575 6.465797629185008 2905.70293303799 3.3979400086720375 2.5422477135385515 -0.9210034982345019 0.8106221076520248 5000.0 509.2137589219569 0.21147687177837257 10.377231461392864 2407.89337689661 3.6989700043360187 2.706900129748221 -0.674737122417858 1.0160815036651816 10000.0 742.8222840526597 0.44273895058490687 18.13494853901047 1677.7884192735014 4.0 2.870884923737559 -0.3538522686695267 1.258516327534016 ==> ketoprofen_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 9.150130250459974e-08 2.868455104686442e-11 1.6200844985826447e-09 3189.9157966637226 -6.0 -7.038572723785637 -10.542351943041266 -8.790462333413451 5e-06 4.575065125229988e-07 1.4342275523432215e-10 8.100422492913223e-09 3189.9157966637226 -5.301029995663981 -6.339602719449618 -9.843381938705248 -8.091492329077433 1e-05 9.150130250459976e-07 2.868455104686443e-10 1.6200844985826446e-08 3189.9157966637226 -5.0 -6.038572723785637 -9.542351943041266 -7.790462333413451 5e-05 4.575065125229987e-06 1.4342275523432215e-09 8.100422492913223e-08 3189.9157966637217 -4.301029995663981 -5.339602719449618 -8.843381938705248 -7.0914923290774325 0.0001 9.150130250459975e-06 2.868455104686443e-09 1.6200844985826446e-07 3189.9157966637217 -4.0 -5.038572723785637 -8.542351943041266 -6.790462333413451 0.001 9.150130250459974e-05 2.8684551046864435e-08 1.6200844985826448e-06 3189.9157966637213 -3.0 -4.038572723785637 -7.542351943041266 -5.790462333413451 0.01 0.0009150130250459974 2.868455104686443e-07 1.6200844985826447e-05 3189.9157966637217 -2.0 -3.038572723785637 -6.542351943041266 -4.790462333413451 0.1 0.009150130250459975 2.8684551046864435e-06 0.0001620084498582643 3189.9157966637217 -1.0 -2.038572723785637 -5.542351943041266 -3.7904623334134517 1.0 0.09150130250459976 2.8684551046864428e-05 0.0016200844985826432 3189.9157966637226 0.0 -1.038572723785637 -4.542351943041266 -2.7904623334134517 10.0 0.9150130250459976 0.00028684551046864433 0.01620084498582644 3189.9157966637217 1.0 -0.03857272378563697 -3.542351943041266 -1.7904623334134515 25.0 2.287532562614994 0.0007171137761716108 0.04050211246456609 3189.9157966637217 1.3979400086720377 0.35936728488640063 -3.1444119343692285 -1.392522324741414 50.0 4.575065125229988 0.0014342275523432217 0.08100422492913219 3189.9157966637217 1.6989700043360187 0.6603972805503818 -2.8433819387052472 -1.0914923290774328 75.0 6.862597687844981 0.0021513413285148323 0.12150633739369825 3189.9157966637217 1.8750612633917 0.8364885396060631 -2.6672906796495663 -0.9154010700217516 100.0 9.150130250459975 0.0028684551046864433 0.1620084498582644 3189.9157966637217 2.0 0.961427276214363 -2.542351943041266 -0.7904623334134515 250.0 22.875325626149937 0.007171137761716108 0.405021124645661 3189.9157966637217 2.3979400086720375 1.3593672848864007 -2.1444119343692285 -0.3925223247414139 500.0 45.750651252299875 0.014342275523432216 0.8100422492913216 3189.9157966637217 2.6989700043360187 1.6603972805503817 -1.8433819387052475 -0.09149232907743288 1000.0 91.50130250459975 0.02868455104686443 1.6200844985826435 3189.9157966637217 3.0 1.961427276214363 -1.5423519430412662 0.20953766658654835 2500.0 339.37691310915 0.11849397135758948 6.341460259386854 2864.085904294515 3.3979400086720375 2.5306822951109122 -0.9263037447824397 0.8021892751642363 5000.0 520.1123012856388 0.20891163646354538 10.423891404192746 2489.6281992238246 3.6989700043360187 2.7160971254866104 -0.6800373689657959 1.0180298782604074 10000.0 774.0378949711114 0.43736848344238083 18.399450542079993 1769.7614809346078 4.0 2.888762223181572 -0.35915251521746455 1.2648048539820538 ==> ketoprofen_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.5177304458762407e-07 2.858196333357557e-10 6.586327956781836e-09 531.0098638652107 -6.0 -6.81880535377885 -9.543907942247218 -8.181356648013034 5e-06 7.588652229381205e-07 1.4290981666787785e-09 3.2931639783909174e-08 531.0098638652108 -5.301029995663981 -6.119835349442831 -8.8449379379112 -7.482386643677016 1e-05 1.517730445876241e-06 2.858196333357557e-09 6.586327956781836e-08 531.0098638652108 -5.0 -5.81880535377885 -8.543907942247218 -7.181356648013034 5e-05 7.588652229381204e-06 1.4290981666787786e-08 3.2931639783909174e-07 531.0098638652107 -4.301029995663981 -5.119835349442831 -7.8449379379112 -6.482386643677016 0.0001 1.5177304458762408e-05 2.8581963333575573e-08 6.586327956781836e-07 531.0098638652107 -4.0 -4.81880535377885 -7.543907942247219 -6.181356648013034 0.001 0.0001517730445876241 2.858196333357557e-07 6.586327956781836e-06 531.0098638652108 -3.0 -3.81880535377885 -6.543907942247219 -5.181356648013034 0.01 0.0015177304458762408 2.8581963333575577e-06 6.586327956781836e-05 531.0098638652106 -2.0 -2.81880535377885 -5.543907942247219 -4.181356648013034 0.1 0.015177304458762407 2.8581963333575568e-05 0.0006586327956781835 531.0098638652107 -1.0 -1.81880535377885 -4.543907942247219 -3.1813566480130344 1.0 0.15177304458762408 0.0002858196333357558 0.0065863279567818355 531.0098638652106 0.0 -0.81880535377885 -3.5439079422472184 -2.1813566480130344 10.0 1.5177304458762408 0.0028581963333575585 0.06586327956781839 531.0098638652105 1.0 0.18119464622114995 -2.5439079422472184 -1.1813566480130342 25.0 3.794326114690602 0.007145490833393894 0.16465819891954595 531.0098638652106 1.3979400086720377 0.5791346548931875 -2.145967933575181 -0.7834166393409967 50.0 7.588652229381204 0.014290981666787788 0.3293163978390919 531.0098638652106 1.6989700043360187 0.8801646505571687 -1.8449379379111996 -0.48238664367701545 75.0 11.382978344071804 0.021436472500181672 0.49397459675863775 531.0098638652107 1.8750612633917 1.0562559096128499 -1.6688466788555185 -0.3062953846213343 100.0 15.177304458762409 0.028581963333575575 0.6586327956781839 531.0098638652106 2.0 1.18119464622115 -1.5439079422472184 -0.18135664801303422 250.0 37.943261146906025 0.07145490833393893 1.6465819891954594 531.0098638652107 2.3979400086720375 1.5791346548931875 -1.145967933575181 0.2165833606590033 500.0 75.88652229381205 0.14290981666787786 3.2931639783909192 531.0098638652107 2.6989700043360187 1.8801646505571687 -0.8449379379111996 0.5176133563229846 1000.0 151.7730445876241 0.2858196333357557 6.586327956781839 531.0098638652107 3.0 2.18119464622115 -0.5439079422472185 0.8186433519869658 2500.0 572.4254285784872 1.153903580836522 25.700656641389465 496.0773483027998 3.3979400086720375 2.757718917970384 0.06216952107266778 1.4099442195215257 5000.0 792.911659044134 1.965409966641243 39.476530715747856 403.4332136817074 3.6989700043360187 2.8992248038033273 0.2934531540393594 1.5963389789213434 10000.0 950.977357090126 3.809749616032256 60.19124206252499 249.6167604002652 4.0 2.978170176445424 0.5808964339567789 1.7795333052011015 ==> ketoprofen_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.0534500773788651e-07 2.1456363321640301e-10 4.754283079650508e-09 490.9732658732452 -6.0 -6.9773860406278825 -9.668443885500697 -8.322914963064289 5e-06 5.267250386894327e-07 1.0728181660820153e-09 2.377141539825254e-08 490.9732658732452 -5.301029995663981 -6.278416036291863 -8.969473881164678 -7.62394495872827 1e-05 1.0534500773788654e-06 2.1456363321640307e-09 4.7542830796505086e-08 490.9732658732452 -5.0 -5.977386040627882 -8.668443885500697 -7.322914963064289 5e-05 5.267250386894326e-06 1.072818166082015e-08 2.377141539825249e-07 490.9732658732453 -4.301029995663981 -5.278416036291863 -7.969473881164679 -6.623944958728271 0.0001 1.0534500773788652e-05 2.14563633216403e-08 4.754283079650489e-07 490.9732658732453 -4.0 -4.9773860406278825 -7.6684438855006976 -6.3229149630642905 0.001 0.0001053450077378865 2.1456363321640305e-07 4.754283079650499e-06 490.9732658732451 -3.0 -3.977386040627882 -6.6684438855006976 -5.32291496306429 0.01 0.0010534500773788653 2.1456363321640304e-06 4.754283079650499e-05 490.9732658732453 -2.0 -2.977386040627882 -5.6684438855006976 -4.32291496306429 0.1 0.010534500773788653 2.1456363321640306e-05 0.00047542830796504985 490.9732658732452 -1.0 -1.977386040627882 -4.6684438855006976 -3.3229149630642896 1.0 0.10534500773788653 0.00021456363321640295 0.004754283079650499 490.9732658732455 0.0 -0.977386040627882 -3.6684438855006976 -2.3229149630642896 10.0 1.0534500773788653 0.0021456363321640305 0.04754283079650499 490.9732658732453 1.0 0.022613959372118 -2.668443885500697 -1.3229149630642896 25.0 2.633625193447163 0.005364090830410077 0.11885707699126244 490.97326587324517 1.3979400086720377 0.42055396804415557 -2.2705038768286596 -0.9249749543922521 50.0 5.267250386894326 0.010728181660820154 0.2377141539825249 490.97326587324517 1.6989700043360187 0.7215839637081367 -1.9694738811646784 -0.6239449587282708 75.0 7.900875580341489 0.01609227249123023 0.3565712309737874 490.9732658732451 1.8750612633917 0.897675222763818 -1.793382622108997 -0.44785369967258953 100.0 10.534500773788652 0.021456363321640307 0.47542830796504987 490.97326587324517 2.0 1.022613959372118 -1.668443885500697 -0.3229149630642896 250.0 26.33625193447163 0.05364090830410075 1.1885707699126244 490.9732658732453 2.3979400086720375 1.4205539680441555 -1.2705038768286596 0.07502504560774795 500.0 52.67250386894326 0.1072818166082015 2.377141539825249 490.9732658732453 2.6989700043360187 1.7215839637081367 -0.9694738811646785 0.3760550412717292 1000.0 105.34500773788652 0.214563633216403 4.754283079650498 490.9732658732453 3.0 2.022613959372118 -0.6684438855006973 0.6770850369357103 2500.0 398.47542528170044 0.8662318705359147 18.578808169642137 460.0101183476132 3.3979400086720375 2.6004015428120644 -0.06236584168299919 1.2690178505645326 5000.0 605.916750099519 1.47543062560792 29.8996342731086 410.67112176139347 3.6989700043360187 2.782412958397244 0.16891879389427591 1.47566587614576 10000.0 887.4173055314399 2.859992998573893 50.37863913042141 310.2865307621178 4.0 2.9481278936430204 0.4563649699526634 1.7022464317978419 ==> ketoprofen_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.197603102202716e-07 1.3210039276933327e-10 3.977484634574341e-09 906.5855726060613 -6.0 -6.921687087691911 -9.879095891111435 -8.400391489401674 5e-06 5.988015511013581e-07 6.605019638466663e-10 1.9887423172871745e-08 906.5855726060614 -5.301029995663981 -6.222717083355892 -9.180125886775416 -7.701421485065654 1e-05 1.1976031022027162e-06 1.3210039276933326e-09 3.97748463457435e-08 906.5855726060614 -5.0 -5.921687087691911 -8.879095891111435 -7.400391489401673 5e-05 5.988015511013581e-06 6.6050196384666645e-09 1.9887423172871745e-07 906.5855726060612 -4.301029995663981 -5.222717083355892 -8.180125886775416 -6.701421485065654 0.0001 1.1976031022027161e-05 1.3210039276933329e-08 3.9774846345743576e-07 906.5855726060612 -4.0 -4.921687087691911 -7.879095891111434 -6.400391489401672 0.001 0.00011976031022027161 1.3210039276933328e-07 3.977484634574357e-06 906.5855726060613 -3.0 -3.921687087691911 -6.879095891111434 -5.400391489401672 0.01 0.0011976031022027161 1.3210039276933326e-06 3.977484634574358e-05 906.5855726060614 -2.0 -2.921687087691911 -5.879095891111434 -4.400391489401672 0.1 0.011976031022027161 1.3210039276933326e-05 0.00039774846345743537 906.5855726060614 -1.0 -1.921687087691911 -4.879095891111434 -3.4003914894016725 1.0 0.11976031022027159 0.0001321003927693333 0.003977484634574354 906.5855726060611 0.0 -0.921687087691911 -3.879095891111434 -2.4003914894016725 10.0 1.197603102202716 0.0013210039276933328 0.039774846345743534 906.5855726060612 1.0 0.0783129123080891 -2.879095891111434 -1.4003914894016725 25.0 2.9940077555067903 0.0033025098192333326 0.09943711586435881 906.5855726060612 1.3979400086720377 0.4762529209801267 -2.4811558824393964 -1.002451480729635 50.0 5.988015511013581 0.006605019638466665 0.1988742317287177 906.5855726060612 1.6989700043360187 0.777282916644108 -2.180125886775415 -0.7014214850656536 75.0 8.98202326652037 0.009907529457699996 0.29831134759307654 906.5855726060612 1.8750612633917 0.9533741756997891 -2.004034627719734 -0.5253302260099724 100.0 11.976031022027161 0.01321003927693333 0.3977484634574355 906.5855726060612 2.0 1.0783129123080892 -1.879095891111434 -0.40039148940167235 250.0 29.940077555067905 0.03302509819233332 0.9943711586435884 906.5855726060614 2.3979400086720375 1.4762529209801267 -1.4811558824393964 -0.00245148072963485 500.0 59.88015511013581 0.06605019638466664 1.988742317287177 906.5855726060614 2.6989700043360187 1.777282916644108 -1.1801258867754152 0.2985785149343464 1000.0 119.76031022027162 0.13210039276933327 3.9774846345743526 906.5855726060614 3.0 2.078312912308089 -0.8790958911114342 0.5996085105983274 2500.0 431.74675693525916 0.5376412607028861 15.235644741954811 803.0387332453138 3.3979400086720375 2.6352290840497776 -0.26950740921024546 1.182860837419766 5000.0 655.8661779244312 0.9268617731217559 24.65557317528083 707.6202697576074 3.6989700043360187 2.816815235537623 -0.03298502922832148 1.3919151031546506 10000.0 872.5858545029262 1.8452124832838308 40.126130033504204 472.8918010298898 4.0 2.9408081683561447 0.2660463840475152 1.60342727620183 ==> naproxen_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 4.7350073238778365e-07 1.9629221967005997e-07 3.0486802025761434e-07 2.412223638734499 -6.0 -6.324679344914716 -6.707096913957428 -6.515888129436072 5e-06 2.367503661938918e-06 9.814610983502998e-07 1.5243401012880717e-06 2.412223638734499 -5.301029995663981 -5.625709340578697 -6.008126909621409 -5.816918125100053 1e-05 4.735007323877836e-06 1.9629221967005995e-06 3.048680202576144e-06 2.412223638734499 -5.0 -5.324679344914716 -5.707096913957428 -5.515888129436072 5e-05 2.3675036619389185e-05 9.814610983502998e-06 1.5243401012880716e-05 2.4122236387344995 -4.301029995663981 -4.625709340578697 -5.008126909621409 -4.816918125100053 0.0001 4.735007323877837e-05 1.9629221967005995e-05 3.0486802025761436e-05 2.4122236387344995 -4.0 -4.324679344914716 -4.707096913957428 -4.515888129436072 0.001 0.0004735007323877837 0.00019629221967005996 0.00030486802025761435 2.412223638734499 -3.0 -3.324679344914716 -3.7070969139574284 -3.515888129436072 0.01 0.004735007323877837 0.0019629221967005996 0.0030486802025761436 2.4122236387344995 -2.0 -2.324679344914716 -2.7070969139574284 -2.515888129436072 0.1 0.04735007323877837 0.019629221967005995 0.030486802025761435 2.4122236387344995 -1.0 -1.324679344914716 -1.7070969139574281 -1.515888129436072 1.0 0.4735007323877836 0.19629221967005997 0.3048680202576143 2.4122236387344986 0.0 -0.3246793449147161 -0.7070969139574281 -0.5158881294360721 10.0 4.735007323877836 1.9629221967005996 3.048680202576143 2.4122236387344986 1.0 0.6753206550852839 0.29290308604257187 0.4841118705639279 25.0 11.837518309694593 4.907305491751499 7.621700506440357 2.4122236387344995 1.3979400086720377 1.0732606637573217 0.6908430947146095 0.8820518792359655 50.0 23.675036619389186 9.814610983502998 15.243401012880716 2.4122236387344995 1.6989700043360187 1.3742906594213027 0.9918730903785906 1.1830818748999468 75.0 35.51255492908378 14.721916475254496 22.86510151932107 2.4122236387344995 1.8750612633917 1.550381918476984 1.1679643494342717 1.3591731339556279 100.0 47.35007323877837 19.629221967005996 30.48680202576144 2.4122236387344995 2.0 1.675320655085284 1.2929030860425719 1.484111870563928 250.0 227.93219314189602 94.36371765254408 146.6578641517973 2.415464320525855 2.3979400086720375 2.3578056692631946 1.9748050424740573 2.166305355868626 500.0 345.23440066648226 143.8884802079895 222.87945896249894 2.39931925173891 2.6989700043360187 2.5381140642020883 2.1580260254698347 2.3480700448359615 1000.0 571.5653198532776 243.85132633586295 373.3322398799809 2.3439090057113137 3.0 2.7570658697808037 2.3871251221124528 2.5720954959466282 2500.0 1188.1728228809752 551.2074267544738 809.2772604242762 2.1555820281250075 3.3979400086720375 3.0748796145212194 2.741315060453919 2.908097337487569 5000.0 2053.5841413593776 1089.5567051305463 1495.8263170461564 1.8847886775322311 3.6989700043360187 3.3125125018716526 3.0372498376886914 3.174881169780172 10000.0 2629.113273330969 1496.1148166747769 1983.294058617325 1.7572937879021633 4.0 3.419809297754453 3.174964923966187 3.2973871108603197 ==> naproxen_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 3.95301899172078e-07 1.9924630796793503e-07 2.8064647502284727e-07 1.983986068317484 -6.0 -6.403071099145589 -6.700609717329634 -6.551840408237611 5e-06 1.97650949586039e-06 9.962315398396755e-07 1.4032323751142361e-06 1.9839860683174835 -5.301029995663981 -5.7041010948095705 -6.001639712993615 -5.852870403901592 1e-05 3.95301899172078e-06 1.992463079679351e-06 2.8064647502284727e-06 1.9839860683174835 -5.0 -5.403071099145589 -5.700609717329634 -5.551840408237611 5e-05 1.9765094958603902e-05 9.962315398396753e-06 1.4032323751142362e-05 1.983986068317484 -4.301029995663981 -4.7041010948095705 -5.001639712993615 -4.852870403901592 0.0001 3.9530189917207804e-05 1.9924630796793507e-05 2.8064647502284728e-05 1.983986068317484 -4.0 -4.403071099145589 -4.700609717329634 -4.551840408237611 0.001 0.000395301899172078 0.0001992463079679351 0.00028064647502284697 1.9839860683174835 -3.0 -3.4030710991455893 -3.700609717329634 -3.5518404082376116 0.01 0.00395301899172078 0.0019924630796793502 0.002806464750228467 1.9839860683174841 -2.0 -2.4030710991455893 -2.7006097173296344 -2.551840408237612 0.1 0.03953018991720781 0.01992463079679351 0.028064647502284698 1.983986068317484 -1.0 -1.403071099145589 -1.7006097173296342 -1.5518404082376116 1.0 0.39530189917207803 0.19924630796793505 0.280646475022847 1.983986068317484 0.0 -0.4030710991455891 -0.7006097173296342 -0.5518404082376116 10.0 3.9530189917207803 1.9924630796793508 2.8064647502284696 1.9839860683174837 1.0 0.596928900854411 0.2993902826703658 0.4481595917623884 25.0 9.88254747930195 4.981157699198376 7.016161875571172 1.9839860683174837 1.3979400086720377 0.9948689095264485 0.6973302913424034 0.8460996004344259 50.0 19.7650949586039 9.962315398396752 14.032323751142348 1.9839860683174837 1.6989700043360187 1.2958989051904297 0.9983602870063846 1.1471295960984071 75.0 29.64764243790586 14.94347309759513 21.048485626713525 1.9839860683174844 1.8750612633917 1.471990164246111 1.174451546062066 1.3232208551540885 100.0 39.5301899172078 19.924630796793505 28.0646475022847 1.9839860683174837 2.0 1.596928900854411 1.2993902826703658 1.4481595917623884 250.0 189.4654008116609 95.80290173539537 134.72689106565488 1.9776582690048206 2.3979400086720375 2.27752991293999 1.9813786634479076 2.1294542881939487 500.0 287.49316208207296 146.1310508035437 204.96750443396334 1.9673653238049609 2.6989700043360187 2.458627519615773 2.164742507240449 2.311685013428111 1000.0 481.5832857872547 247.83680587091212 345.47657418460625 1.9431467577825845 3.0 2.6826714055414427 2.3941658032493125 2.5384186043953774 2500.0 1040.6999018638812 561.6147251402972 764.5079393563016 1.853049528934455 3.3979400086720375 3.0173255136085397 2.749438486164731 2.8833819998866357 5000.0 1904.5200103623674 1115.3847835317072 1457.4884697622247 1.7075004415354995 3.6989700043360187 3.2797855400551446 3.0474247153991403 3.163605127727142 10000.0 2491.0505623238855 1537.3095843004978 1956.9148945310965 1.6203961698823053 4.0 3.3963825427574608 3.1867613347831516 3.291571938770306 ==> naproxen_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 4.614963046438553e-07 1.5773430131439063e-07 2.6980325641506197e-07 2.9257827929513986 -6.0 -6.335831772166147 -6.8020738535849326 -6.56895281287554 5e-06 2.3074815232192764e-06 7.886715065719531e-07 1.3490162820753098e-06 2.9257827929513986 -5.301029995663981 -5.636861767830128 -6.103103849248914 -5.869982808539521 1e-05 4.614963046438553e-06 1.5773430131439062e-06 2.69803256415062e-06 2.9257827929513986 -5.0 -5.335831772166147 -5.8020738535849326 -5.56895281287554 5e-05 2.3074815232192767e-05 7.886715065719533e-06 1.3490162820753124e-05 2.9257827929513986 -4.301029995663981 -4.636861767830127 -5.103103849248914 -4.86998280853952 0.0001 4.6149630464385534e-05 1.5773430131439065e-05 2.6980325641506198e-05 2.9257827929513986 -4.0 -4.335831772166147 -4.8020738535849326 -4.56895281287554 0.001 0.0004614963046438553 0.00015773430131439065 0.00026980325641506197 2.9257827929513986 -3.0 -3.3358317721661463 -3.802073853584933 -3.5689528128755397 0.01 0.004614963046438553 0.0015773430131439063 0.00269803256415062 2.925782792951399 -2.0 -2.3358317721661463 -2.802073853584933 -2.5689528128755397 0.1 0.04614963046438553 0.015773430131439063 0.0269803256415062 2.9257827929513986 -1.0 -1.3358317721661463 -1.802073853584933 -1.5689528128755397 1.0 0.4614963046438553 0.15773430131439062 0.269803256415062 2.925782792951399 0.0 -0.3358317721661464 -0.802073853584933 -0.5689528128755397 10.0 4.614963046438553 1.5773430131439061 2.6980325641506195 2.925782792951399 1.0 0.6641682278338535 0.19792614641506703 0.4310471871244603 25.0 11.537407616096383 3.9433575328597654 6.7450814103765495 2.925782792951399 1.3979400086720377 1.0621082365058911 0.5958661550871047 0.8289871957964979 50.0 23.074815232192766 7.886715065719531 13.490162820753097 2.925782792951399 1.6989700043360187 1.3631382321698724 0.8968961507510859 1.130017191460479 75.0 34.61222284828915 11.830072598579298 20.235244231129652 2.9257827929513986 1.8750612633917 1.5392294912255537 1.072987409806767 1.3061084505161604 100.0 46.14963046438553 15.773430131439062 26.980325641506198 2.925782792951399 2.0 1.6641682278338537 1.197926146415067 1.4310471871244603 250.0 221.14010096952765 75.9111447004179 129.56464874248235 2.9131440691910715 2.3979400086720375 2.3446675035494824 1.8803055404091096 2.112486521979296 500.0 334.79664000282065 115.96166546659354 197.03699136798315 2.8871320419183655 2.6989700043360187 2.524781090792081 2.064314444159307 2.2945477674756942 1000.0 560.0185968655684 197.3312847158704 332.4292243234064 2.8379615410294283 3.0 2.7482024491169055 2.2951959433484705 2.521699196232688 2500.0 1196.0847165623693 452.15417948123655 735.4010495010901 2.6453027990024456 3.3979400086720375 3.077761941050869 2.6552865495911226 2.8665242453209956 5000.0 2144.345637933558 916.7301187969905 1402.0649882957061 2.339124235110271 3.6989700043360187 3.331294788739456 2.962241500153899 3.1467681444466775 10000.0 2768.8976346946415 1284.1881856031994 1885.6790897762796 2.1561463232073383 4.0 3.4423069003071416 3.1086286701351096 3.2754677852211254 ==> naproxen_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 3.889138395780453e-07 1.8986251654143376e-07 2.7173546014475043e-07 2.048397159495 -6.0 -6.410146602120131 -6.721560767048305 -6.5658536845842175 5e-06 1.944569197890227e-06 9.493125827071689e-07 1.358677300723752e-06 2.048397159495 -5.301029995663981 -5.711176597784112 -6.022590762712286 -5.866883680248199 1e-05 3.889138395780454e-06 1.8986251654143379e-06 2.7173546014475044e-06 2.048397159495 -5.0 -5.410146602120131 -5.721560767048305 -5.5658536845842175 5e-05 1.9445691978902273e-05 9.49312582707169e-06 1.358677300723752e-05 2.0483971594950003 -4.301029995663981 -4.711176597784112 -5.022590762712286 -4.866883680248199 0.0001 3.889138395780455e-05 1.898625165414338e-05 2.7173546014475043e-05 2.0483971594950003 -4.0 -4.410146602120131 -4.721560767048305 -4.5658536845842175 0.001 0.0003889138395780454 0.0001898625165414338 0.00027173546014475016 2.048397159495 -3.0 -3.4101466021201308 -3.721560767048305 -3.565853684584218 0.01 0.0038891383957804547 0.0018986251654143382 0.0027173546014475046 2.048397159495 -2.0 -2.4101466021201303 -2.7215607670483046 -2.5658536845842175 0.1 0.03889138395780454 0.01898625165414338 0.02717354601447503 2.0483971594949995 -1.0 -1.4101466021201305 -1.7215607670483049 -1.5658536845842177 1.0 0.38891383957804543 0.1898625165414338 0.2717354601447503 2.048397159495 0.0 -0.41014660212013054 -0.7215607670483049 -0.5658536845842177 10.0 3.8891383957804537 1.8986251654143376 2.7173546014475027 2.048397159495 1.0 0.5898533978798695 0.27843923295169504 0.43414631541578225 25.0 9.722845989451134 4.746562913535844 6.7933865036187555 2.048397159495 1.3979400086720377 0.987793406551907 0.6763792416237326 0.8320863240878198 50.0 19.445691978902268 9.493125827071689 13.586773007237513 2.048397159495 1.6989700043360187 1.2888234022158882 0.9774092372877139 1.133116319751801 75.0 29.1685379683534 14.239688740607532 20.380159510856263 2.048397159495 1.8750612633917 1.4649146612715693 1.153500496343395 1.3092075788074822 100.0 38.891383957804535 18.986251654143377 27.17354601447503 2.048397159495 2.0 1.5898533978798695 1.2784392329516951 1.4341463154157823 250.0 186.2845270485973 91.32813554468459 130.43396235709386 2.0397276911171907 2.3979400086720375 2.270176783524895 1.960604591657321 2.115390687591108 500.0 282.95530199812845 139.39819338747864 198.6037711322409 2.0298347856748102 2.6989700043360187 2.451717836129473 2.144257145304794 2.2979874907171336 1000.0 474.5969310382714 236.76654370758953 335.214371732718 2.0044932176921337 3.0 2.6763249255428176 2.374320334411934 2.525322629977376 2500.0 1030.7447288527296 539.0052874476868 745.3702830543036 1.9123091235960625 3.3979400086720375 3.013151122531338 2.7315930254800422 2.87237207400569 5000.0 1896.5328779975414 1078.6701892191606 1430.291396314041 1.7582138608747722 3.6989700043360187 3.277960375965327 3.032888676473921 3.1554245262196243 10000.0 2488.110722272683 1494.5012494404666 1928.337258672028 1.664843521010249 4.0 3.3958697027881164 3.174496282456513 3.285182992622315 ==> naproxen_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 4.192809822683482e-07 1.7964339992566837e-07 2.744468275984621e-07 2.333962630644017 -6.0 -6.377494835863125 -6.745588734087034 -6.56154178497508 5e-06 2.096404911341741e-06 8.98216999628342e-07 1.3722341379923101e-06 2.3339626306440167 -5.301029995663981 -5.678524831527106 -6.046618729751016 -5.862571780639061 1e-05 4.192809822683482e-06 1.796433999256684e-06 2.7444682759846207e-06 2.3339626306440167 -5.0 -5.377494835863125 -5.745588734087034 -5.56154178497508 5e-05 2.0964049113417412e-05 8.98216999628342e-06 1.372234137992313e-05 2.3339626306440167 -4.301029995663981 -4.678524831527105 -5.046618729751016 -4.86257178063906 0.0001 4.1928098226834824e-05 1.796433999256684e-05 2.7444682759846205e-05 2.3339626306440167 -4.0 -4.377494835863125 -4.745588734087034 -4.56154178497508 0.001 0.0004192809822683482 0.00017964339992566837 0.00027444682759846206 2.333962630644017 -3.0 -3.3774948358631245 -3.745588734087035 -3.5615417849750797 0.01 0.004192809822683483 0.001796433999256684 0.0027444682759846205 2.333962630644017 -2.0 -2.3774948358631245 -2.745588734087035 -2.5615417849750797 0.1 0.04192809822683482 0.01796433999256684 0.027444682759846205 2.3339626306440167 -1.0 -1.3774948358631245 -1.7455887340870346 -1.5615417849750797 1.0 0.4192809822683482 0.17964339992566838 0.27444682759846206 2.333962630644017 0.0 -0.3774948358631246 -0.7455887340870349 -0.5615417849750797 10.0 4.192809822683482 1.7964339992566838 2.7444682759846204 2.333962630644017 1.0 0.6225051641368754 0.2544112659129652 0.43845821502492033 25.0 10.482024556708705 4.4910849981417105 6.861170689961551 2.3339626306440167 1.3979400086720377 1.020445172808913 0.6523512745850029 0.8363982236969579 50.0 20.96404911341741 8.982169996283421 13.722341379923101 2.3339626306440167 1.6989700043360187 1.3214751684728943 0.9533812702489841 1.137428219360939 75.0 31.446073670126115 13.473254994425128 20.583512069884655 2.333962630644017 1.8750612633917 1.4975664275285756 1.1294725293046652 1.3135194784166204 100.0 41.92809822683482 17.964339992566842 27.444682759846206 2.3339626306440167 2.0 1.6225051641368755 1.2544112659129654 1.4384582150249203 250.0 200.88069290612762 86.41798977828103 131.75623577734666 2.3245240189168794 2.3979400086720375 2.302938197737466 1.9366041597031227 2.1197711787202946 500.0 304.5530647148638 131.91818960745871 200.43973891568527 2.30865103304635 2.6989700043360187 2.4836629741610556 2.1203046825933622 2.301983828377209 1000.0 510.32769396350545 224.1229483727089 338.195427833296 2.276998842237466 3.0 2.70784913683935 2.350486327045467 2.529167731942408 2500.0 1099.8066864184514 510.786598327917 749.5108512716668 2.153162768989473 3.3979400086720375 3.0413163557039344 2.7082394940170094 2.8747779248604717 5000.0 2000.1313839371628 1025.0531398839757 1431.8662490907695 1.9512465316320622 3.6989700043360187 3.3010585243863977 3.0107463802797394 3.1559024523330685 10000.0 2605.4719139891904 1424.1414104120947 1926.281507562605 1.8295036538789091 4.0 3.415886395996253 3.1535531148011953 3.284719755398724 ==> nifedipine_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.4112191970028794e-08 2.4506818973949637e-11 5.880858219130278e-10 575.847562469443 -6.0 -7.8504055244063355 -10.610713057239037 -9.230559290822686 5e-06 7.056095985014397e-08 1.225340948697482e-10 2.9404291095651387e-09 575.8475624694429 -5.301029995663981 -7.151435520070317 -9.911743052903018 -8.531589286486668 1e-05 1.4112191970028794e-07 2.450681897394964e-10 5.880858219130278e-09 575.8475624694429 -5.0 -6.8504055244063355 -9.610713057239037 -8.230559290822686 5e-05 7.056095985014397e-07 1.2253409486974818e-09 2.9404291095651384e-08 575.847562469443 -4.301029995663981 -6.151435520070317 -8.911743052903018 -7.531589286486668 0.0001 1.4112191970028795e-06 2.4506818973949637e-09 5.8808582191302775e-08 575.847562469443 -4.0 -5.8504055244063355 -8.610713057239037 -7.230559290822686 0.001 1.4112191970028793e-05 2.450681897394963e-08 5.880858219130278e-07 575.847562469443 -3.0 -4.850405524406336 -7.610713057239037 -6.230559290822686 0.01 0.00014112191970028792 2.450681897394963e-07 5.880858219130278e-06 575.8475624694431 -2.0 -3.850405524406336 -6.610713057239037 -5.230559290822686 0.1 0.001411219197002879 2.4506818973949634e-06 5.880858219130278e-05 575.8475624694429 -1.0 -2.850405524406336 -5.610713057239037 -4.230559290822686 1.0 0.014112191970028791 2.4506818973949633e-05 0.0005880858219130278 575.847562469443 0.0 -1.850405524406336 -4.610713057239037 -3.2305592908226863 10.0 0.09751341366877563 0.00034538464506276325 0.005803415870747889 282.33279927964224 1.0 -1.0109356398743397 -3.461696973985536 -2.236316306929938 25.0 0.16501310688693366 0.0011721406716392235 0.013907500635834085 140.7792689730363 1.3979400086720377 -0.7824815586794369 -2.9310202643839958 -1.8567509115317162 50.0 0.20735871558905372 0.0032961510086949083 0.026143558280206234 62.90934943273615 1.6989700043360187 -0.6832777058862467 -2.4819928999055607 -1.5826353028959037 75.0 0.20735871558905372 0.0032961510086949083 0.026143558280206234 62.90934943273615 1.8750612633917 -0.6832777058862467 -2.4819928999055607 -1.5826353028959037 100.0 0.20735871558905372 0.0032961510086949083 0.026143558280206234 62.90934943273615 2.0 -0.6832777058862467 -2.4819928999055607 -1.5826353028959037 250.0 0.20735871558905372 0.0032961510086949083 0.026143558280206234 62.90934943273615 2.3979400086720375 -0.6832777058862467 -2.4819928999055607 -1.5826353028959037 500.0 0.20735871558905372 0.0032961510086949083 0.026143558280206234 62.90934943273615 2.6989700043360187 -0.6832777058862467 -2.4819928999055607 -1.5826353028959037 1000.0 0.20735871558905372 0.0032961510086949083 0.026143558280206234 62.90934943273615 3.0 -0.6832777058862467 -2.4819928999055607 -1.5826353028959037 2500.0 0.20735871558905372 0.0032961510086949083 0.026143558280206234 62.90934943273615 3.3979400086720375 -0.6832777058862467 -2.4819928999055607 -1.5826353028959037 5000.0 0.20735871558905372 0.0032961510086949083 0.026143558280206234 62.90934943273615 3.6989700043360187 -0.6832777058862467 -2.4819928999055607 -1.5826353028959037 10000.0 0.20735871558905372 0.0032961510086949083 0.026143558280206234 62.90934943273615 4.0 -0.6832777058862467 -2.4819928999055607 -1.5826353028959037 ==> nifedipine_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.2070500921603955e-08 2.429462045059921e-11 5.415239962725337e-10 496.83842339287276 -6.0 -7.918274706458216 -10.614489881433162 -9.26638229394569 5e-06 6.035250460801978e-08 1.2147310225299607e-10 2.7076199813626685e-09 496.8384233928727 -5.301029995663981 -7.219304702122197 -9.915519877097143 -8.56741228960967 1e-05 1.2070500921603957e-07 2.4294620450599215e-10 5.415239962725338e-09 496.8384233928727 -5.0 -6.918274706458216 -9.614489881433162 -8.26638229394569 5e-05 6.035250460801979e-07 1.2147310225299609e-09 2.7076199813626683e-08 496.8384233928727 -4.301029995663981 -6.219304702122197 -8.915519877097143 -7.5674122896096705 0.0001 1.2070500921603957e-06 2.4294620450599217e-09 5.4152399627253374e-08 496.8384233928727 -4.0 -5.918274706458216 -8.614489881433162 -7.266382293945689 0.001 1.2070500921603955e-05 2.4294620450599212e-08 5.415239962725349e-07 496.8384233928727 -3.0 -4.918274706458216 -7.614489881433161 -6.266382293945688 0.01 0.00012070500921603956 2.429462045059921e-07 5.415239962725348e-06 496.83842339287276 -2.0 -3.9182747064582157 -6.614489881433161 -5.266382293945688 0.1 0.0012070500921603953 2.4294620450599217e-06 5.415239962725349e-05 496.8384233928725 -1.0 -2.918274706458216 -5.614489881433161 -4.266382293945688 1.0 0.012070500921603956 2.4294620450599215e-05 0.0005415239962725349 496.8384233928727 0.0 -1.918274706458216 -4.614489881433161 -3.2663822939456884 10.0 0.10197401208132559 0.00034239404429363835 0.005908916517380613 297.82647736089797 1.0 -0.9915104934117716 -3.4654737981797674 -2.2284921457957694 25.0 0.16764078232523957 0.0011619913935973808 0.013956974825436215 144.27024438300234 1.3979400086720377 -0.7756203211217663 -2.9347970885782253 -1.855208704849996 50.0 0.20760156897807513 0.00326761044708438 0.026045365338652225 63.53314519584598 1.6989700043360187 -0.6827693685695077 -2.485769724099788 -1.584269546334648 75.0 0.20760156897807513 0.00326761044708438 0.026045365338652225 63.53314519584598 1.8750612633917 -0.6827693685695077 -2.485769724099788 -1.584269546334648 100.0 0.20760156897807513 0.00326761044708438 0.026045365338652225 63.53314519584598 2.0 -0.6827693685695077 -2.485769724099788 -1.584269546334648 250.0 0.20760156897807513 0.00326761044708438 0.026045365338652225 63.53314519584598 2.3979400086720375 -0.6827693685695077 -2.485769724099788 -1.584269546334648 500.0 0.20760156897807513 0.00326761044708438 0.026045365338652225 63.53314519584598 2.6989700043360187 -0.6827693685695077 -2.485769724099788 -1.584269546334648 1000.0 0.20760156897807513 0.00326761044708438 0.026045365338652225 63.53314519584598 3.0 -0.6827693685695077 -2.485769724099788 -1.584269546334648 2500.0 0.20760156897807513 0.00326761044708438 0.026045365338652225 63.53314519584598 3.3979400086720375 -0.6827693685695077 -2.485769724099788 -1.584269546334648 5000.0 0.20760156897807513 0.00326761044708438 0.026045365338652225 63.53314519584598 3.6989700043360187 -0.6827693685695077 -2.485769724099788 -1.584269546334648 10000.0 0.20760156897807513 0.00326761044708438 0.026045365338652225 63.53314519584598 4.0 -0.6827693685695077 -2.485769724099788 -1.584269546334648 ==> nifedipine_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 3.5480572939704964e-08 1.1154231254644353e-10 1.989368029341846e-09 318.0907059366526 -6.0 -7.450009375803577 -9.952560355758493 -8.701284865781036 5e-06 1.7740286469852486e-07 5.577115627322176e-10 9.946840146709228e-09 318.0907059366527 -5.301029995663981 -6.7510393714675585 -9.253590351422474 -8.002314861445017 1e-05 3.548057293970497e-07 1.1154231254644353e-09 1.989368029341846e-08 318.0907059366527 -5.0 -6.450009375803577 -8.952560355758493 -7.7012848657810355 5e-05 1.7740286469852486e-06 5.5771156273221765e-09 9.94684014670923e-08 318.0907059366527 -4.301029995663981 -5.7510393714675585 -8.253590351422474 -7.002314861445017 0.0001 3.5480572939704973e-06 1.1154231254644353e-08 1.9893680293418462e-07 318.0907059366527 -4.0 -5.450009375803577 -7.952560355758494 -6.7012848657810355 0.001 3.548057293970497e-05 1.1154231254644352e-07 1.989368029341846e-06 318.0907059366527 -3.0 -4.450009375803577 -6.952560355758494 -5.7012848657810355 0.01 0.0003548057293970497 1.115423125464435e-06 1.989368029341846e-05 318.0907059366527 -2.0 -3.4500093758035777 -5.952560355758494 -4.7012848657810355 0.1 0.0035480572939704962 1.1154231254644356e-05 0.00019893680293418462 318.0907059366525 -1.0 -2.4500093758035777 -4.952560355758494 -3.7012848657810355 1.0 0.03548057293970496 0.00011154231254644353 0.0019893680293418463 318.09070593665257 0.0 -1.4500093758035777 -3.952560355758494 -2.7012848657810355 10.0 0.1427389722141043 0.0014280291167736029 0.014277093836634933 99.95522537845696 1.0 -0.8454574346867689 -2.8452629374301592 -1.845360186058464 25.0 0.17224540003908803 0.004028692025242189 0.026342430972143106 42.75467048855226 1.3979400086720377 -0.7638523674715206 -2.394835931134854 -1.5793441493031875 50.0 0.20001722342933181 0.008779332805954393 0.04190486572474659 22.782736211306908 1.6989700043360187 -0.6989326057447344 -2.0565384874768515 -1.377735546610793 75.0 0.20001722342933181 0.008779332805954393 0.04190486572474659 22.782736211306908 1.8750612633917 -0.6989326057447344 -2.0565384874768515 -1.377735546610793 100.0 0.20001722342933181 0.008779332805954393 0.04190486572474659 22.782736211306908 2.0 -0.6989326057447344 -2.0565384874768515 -1.377735546610793 250.0 0.20001722342933181 0.008779332805954393 0.04190486572474659 22.782736211306908 2.3979400086720375 -0.6989326057447344 -2.0565384874768515 -1.377735546610793 500.0 0.20001722342933181 0.008779332805954393 0.04190486572474659 22.782736211306908 2.6989700043360187 -0.6989326057447344 -2.0565384874768515 -1.377735546610793 1000.0 0.20001722342933181 0.008779332805954393 0.04190486572474659 22.782736211306908 3.0 -0.6989326057447344 -2.0565384874768515 -1.377735546610793 2500.0 0.20001722342933181 0.008779332805954393 0.04190486572474659 22.782736211306908 3.3979400086720375 -0.6989326057447344 -2.0565384874768515 -1.377735546610793 5000.0 0.20001722342933181 0.008779332805954393 0.04190486572474659 22.782736211306908 3.6989700043360187 -0.6989326057447344 -2.0565384874768515 -1.377735546610793 10000.0 0.20001722342933181 0.008779332805954393 0.04190486572474659 22.782736211306908 4.0 -0.6989326057447344 -2.0565384874768515 -1.377735546610793 ==> nifedipine_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.5281556769596727e-08 8.848349558434884e-11 1.1628265394909879e-09 172.70516573375252 -6.0 -7.8158324008646165 -10.05313772868171 -8.934485064773163 5e-06 7.640778384798365e-08 4.4241747792174433e-10 5.814132697454939e-09 172.70516573375252 -5.301029995663981 -7.116862396528598 -9.35416772434569 -8.235515060437145 1e-05 1.528155676959673e-07 8.848349558434887e-10 1.162826539490988e-08 172.70516573375252 -5.0 -6.8158324008646165 -9.05313772868171 -7.934485064773163 5e-05 7.640778384798365e-07 4.424174779217441e-09 5.8141326974549386e-08 172.7051657337526 -4.301029995663981 -6.116862396528598 -8.354167724345691 -7.2355150604371445 0.0001 1.528155676959673e-06 8.848349558434882e-09 1.162826539490988e-07 172.7051657337526 -4.0 -5.8158324008646165 -8.05313772868171 -6.934485064773163 0.001 1.5281556769596727e-05 8.848349558434883e-08 1.1628265394909879e-06 172.70516573375255 -3.0 -4.8158324008646165 -7.053137728681709 -5.934485064773163 0.01 0.00015281556769596727 8.848349558434883e-07 1.162826539490988e-05 172.70516573375255 -2.0 -3.8158324008646165 -6.053137728681709 -4.934485064773163 0.1 0.0015281556769596726 8.848349558434885e-06 0.00011628265394909892 172.7051657337525 -1.0 -2.8158324008646165 -5.053137728681709 -3.934485064773163 1.0 0.015281556769596728 8.848349558434884e-05 0.001162826539490989 172.70516573375255 0.0 -1.8158324008646165 -4.053137728681709 -2.934485064773163 10.0 0.13033592812465325 0.0011328189994149467 0.012151008834084027 115.0545040222368 1.0 -0.884935851091051 -2.945839475692552 -1.9153876633918014 25.0 0.18323233470805245 0.0031958923963545287 0.024198983971641292 57.33369963177133 1.3979400086720377 -0.7369978846738745 -2.4954078515283107 -1.6162028681010927 50.0 0.20704118676610156 0.006964983498387968 0.03797418135144665 29.726012533126724 1.6989700043360187 -0.683943251615663 -2.1570799081800804 -1.4205115798978718 75.0 0.20704118676610156 0.006964983498387968 0.03797418135144665 29.726012533126724 1.8750612633917 -0.683943251615663 -2.1570799081800804 -1.4205115798978718 100.0 0.20704118676610156 0.006964983498387968 0.03797418135144665 29.726012533126724 2.0 -0.683943251615663 -2.1570799081800804 -1.4205115798978718 250.0 0.20704118676610156 0.006964983498387968 0.03797418135144665 29.726012533126724 2.3979400086720375 -0.683943251615663 -2.1570799081800804 -1.4205115798978718 500.0 0.20704118676610156 0.006964983498387968 0.03797418135144665 29.726012533126724 2.6989700043360187 -0.683943251615663 -2.1570799081800804 -1.4205115798978718 1000.0 0.20704118676610156 0.006964983498387968 0.03797418135144665 29.726012533126724 3.0 -0.683943251615663 -2.1570799081800804 -1.4205115798978718 2500.0 0.20704118676610156 0.006964983498387968 0.03797418135144665 29.726012533126724 3.3979400086720375 -0.683943251615663 -2.1570799081800804 -1.4205115798978718 5000.0 0.20704118676610156 0.006964983498387968 0.03797418135144665 29.726012533126724 3.6989700043360187 -0.683943251615663 -2.1570799081800804 -1.4205115798978718 10000.0 0.20704118676610156 0.006964983498387968 0.03797418135144665 29.726012533126724 4.0 -0.683943251615663 -2.1570799081800804 -1.4205115798978718 ==> nifedipine_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 2.0081472406371922e-08 6.738599726664315e-11 1.1632755669599302e-09 298.0066070241641 -6.0 -7.697204447178471 -10.17143033998737 -8.934317393582921 5e-06 1.0040736203185963e-07 3.369299863332158e-10 5.81637783479965e-09 298.00660702416417 -5.301029995663981 -6.9982344428424526 -9.472460335651352 -8.235347389246902 1e-05 2.0081472406371926e-07 6.738599726664316e-10 1.1632755669599302e-08 298.00660702416417 -5.0 -6.697204447178471 -9.17143033998737 -7.934317393582921 5e-05 1.0040736203185965e-06 3.369299863332158e-09 5.81637783479965e-08 298.00660702416417 -4.301029995663981 -5.9982344428424526 -8.472460335651352 -7.235347389246902 0.0001 2.008147240637193e-06 6.738599726664316e-09 1.1632755669599302e-07 298.00660702416417 -4.0 -5.697204447178471 -8.17143033998737 -6.934317393582921 0.001 2.0081472406371928e-05 6.738599726664316e-08 1.1632755669599302e-06 298.00660702416417 -3.0 -4.697204447178471 -7.17143033998737 -5.934317393582921 0.01 0.00020081472406371925 6.738599726664316e-07 1.1632755669599301e-05 298.0066070241641 -2.0 -3.6972044471784713 -6.17143033998737 -4.934317393582921 0.1 0.0020081472406371925 6.7385997266643155e-06 0.00011632755669599314 298.0066070241641 -1.0 -2.6972044471784713 -5.17143033998737 -3.9343173935829205 1.0 0.020081472406371925 6.738599726664316e-05 0.0011632755669599313 298.0066070241641 0.0 -1.6972044471784713 -4.17143033998737 -2.9343173935829205 10.0 0.12911048590167168 0.0008922013295079797 0.010732779098392585 144.7100353155402 1.0 -0.8890384844237419 -3.0495371339328363 -1.969287809178289 25.0 0.17151965462577834 0.0026818409333380284 0.021447340875908452 63.95593880815728 1.3979400086720377 -0.765686106487497 -2.571566984807393 -1.6686265456474452 50.0 0.20239476739184978 0.006370346895211933 0.03590717028758756 31.77138870474594 1.6989700043360187 -0.6938007197088258 -2.1958369176529793 -1.4448188186809026 75.0 0.20239476739184978 0.006370346895211933 0.03590717028758756 31.77138870474594 1.8750612633917 -0.6938007197088258 -2.1958369176529793 -1.4448188186809026 100.0 0.20239476739184978 0.006370346895211933 0.03590717028758756 31.77138870474594 2.0 -0.6938007197088258 -2.1958369176529793 -1.4448188186809026 250.0 0.20239476739184978 0.006370346895211933 0.03590717028758756 31.77138870474594 2.3979400086720375 -0.6938007197088258 -2.1958369176529793 -1.4448188186809026 500.0 0.20239476739184978 0.006370346895211933 0.03590717028758756 31.77138870474594 2.6989700043360187 -0.6938007197088258 -2.1958369176529793 -1.4448188186809026 1000.0 0.20239476739184978 0.006370346895211933 0.03590717028758756 31.77138870474594 3.0 -0.6938007197088258 -2.1958369176529793 -1.4448188186809026 2500.0 0.20239476739184978 0.006370346895211933 0.03590717028758756 31.77138870474594 3.3979400086720375 -0.6938007197088258 -2.1958369176529793 -1.4448188186809026 5000.0 0.20239476739184978 0.006370346895211933 0.03590717028758756 31.77138870474594 3.6989700043360187 -0.6938007197088258 -2.1958369176529793 -1.4448188186809026 10000.0 0.20239476739184978 0.006370346895211933 0.03590717028758756 31.77138870474594 4.0 -0.6938007197088258 -2.1958369176529793 -1.4448188186809026 ==> phenytoin_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.1861294537619648e-07 2.5823319397031032e-08 5.5344195477684206e-08 4.593249363202846 -6.0 -6.925867909634152 -7.587987933132472 -7.256927921383312 5e-06 5.930647268809826e-07 1.2911659698515516e-07 2.76720977388421e-07 4.593249363202847 -5.301029995663981 -6.2268979052981335 -6.889017928796453 -6.557957917047293 1e-05 1.1861294537619652e-06 2.582331939703103e-07 5.534419547768421e-07 4.593249363202847 -5.0 -5.925867909634152 -6.587987933132472 -6.256927921383312 5e-05 5.930647268809825e-06 1.2911659698515518e-06 2.76720977388421e-06 4.593249363202846 -4.301029995663981 -5.2268979052981335 -5.889017928796453 -5.557957917047293 0.0001 1.186129453761965e-05 2.5823319397031036e-06 5.5344195477684204e-06 4.593249363202846 -4.0 -4.925867909634152 -5.587987933132472 -5.256927921383312 0.001 0.00011861294537619648 2.582331939703103e-05 5.534419547768421e-05 4.593249363202847 -3.0 -3.9258679096341527 -4.587987933132472 -4.256927921383312 0.01 0.001186129453761965 0.0002582331939703103 0.000553441954776842 4.593249363202847 -2.0 -2.925867909634152 -3.587987933132472 -3.256927921383312 0.1 0.01186129453761965 0.0025823319397031037 0.0055344195477684205 4.593249363202846 -1.0 -1.9258679096341524 -2.5879879331324718 -2.256927921383312 1.0 0.11861294537619649 0.02582331939703104 0.055344195477684176 4.593249363202845 0.0 -0.9258679096341524 -1.587987933132472 -1.2569279213833122 10.0 0.796851415764579 0.2981144959550836 0.4873940481394415 2.6729710449391875 1.0 -0.09862265141363623 -0.5256169056841116 -0.3121197785488739 25.0 1.2914034848285352 0.6986839429554941 0.9498857187717197 1.8483371456423998 1.3979400086720377 0.11106195400706804 -0.15571923751845745 -0.022328641755694698 50.0 1.9469990440088918 1.2487546050275216 1.559270349294915 1.5591526438983434 1.6989700043360187 0.28936573827824175 0.09647710278307098 0.19292142053065636 75.0 1.9469990440088918 1.2487546050275216 1.559270349294915 1.5591526438983434 1.8750612633917 0.28936573827824175 0.09647710278307098 0.19292142053065636 100.0 1.9469990440088918 1.2487546050275216 1.559270349294915 1.5591526438983434 2.0 0.28936573827824175 0.09647710278307098 0.19292142053065636 250.0 1.9469990440088918 1.2487546050275216 1.559270349294915 1.5591526438983434 2.3979400086720375 0.28936573827824175 0.09647710278307098 0.19292142053065636 500.0 1.9469990440088918 1.2487546050275216 1.559270349294915 1.5591526438983434 2.6989700043360187 0.28936573827824175 0.09647710278307098 0.19292142053065636 1000.0 1.9469990440088918 1.2487546050275216 1.559270349294915 1.5591526438983434 3.0 0.28936573827824175 0.09647710278307098 0.19292142053065636 2500.0 1.9469990440088918 1.2487546050275216 1.559270349294915 1.5591526438983434 3.3979400086720375 0.28936573827824175 0.09647710278307098 0.19292142053065636 5000.0 1.9469990440088918 1.2487546050275216 1.559270349294915 1.5591526438983434 3.6989700043360187 0.28936573827824175 0.09647710278307098 0.19292142053065636 10000.0 1.9469990440088918 1.2487546050275216 1.559270349294915 1.5591526438983434 4.0 0.28936573827824175 0.09647710278307098 0.19292142053065636 ==> phenytoin_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 4.367076448424032e-08 2.6034676205836683e-08 3.371875165258275e-08 1.677407628924143 -6.0 -7.359809205413649 -7.584447819290108 -7.472128512351878 5e-06 2.1835382242120163e-07 1.3017338102918342e-07 1.6859375826291374e-07 1.6774076289241433 -5.301029995663981 -6.66083920107763 -6.885477814954089 -6.773158508015859 1e-05 4.3670764484240325e-07 2.6034676205836685e-07 3.371875165258275e-07 1.6774076289241433 -5.0 -6.359809205413649 -6.584447819290108 -6.472128512351878 5e-05 2.1835382242120163e-06 1.3017338102918342e-06 1.6859375826291373e-06 1.6774076289241433 -4.301029995663981 -5.66083920107763 -5.885477814954089 -5.773158508015859 0.0001 4.3670764484240325e-06 2.6034676205836684e-06 3.371875165258275e-06 1.6774076289241433 -4.0 -5.359809205413649 -5.584447819290108 -5.472128512351878 0.001 4.367076448424032e-05 2.6034676205836685e-05 3.371875165258275e-05 1.677407628924143 -3.0 -4.359809205413649 -4.584447819290108 -4.472128512351878 0.01 0.0004367076448424032 0.0002603467620583669 0.0003371875165258272 1.6774076289241429 -2.0 -3.359809205413649 -3.5844478192901077 -3.4721285123518784 0.1 0.0043670764484240315 0.002603467620583668 0.0033718751652582718 1.677407628924143 -1.0 -2.359809205413649 -2.5844478192901077 -2.4721285123518784 1.0 0.043670764484240315 0.026034676205836677 0.033718751652582715 1.6774076289241435 0.0 -1.359809205413649 -1.584447819290108 -1.4721285123518784 10.0 0.491249654993338 0.30107015376684687 0.3845784824541732 1.6316783608307084 1.0 -0.30869774162321845 -0.521332295622517 -0.4150150186228677 25.0 1.0907430974737466 0.708098863782832 0.8788367015550311 1.5403824991989654 1.3979400086720377 0.03772247333105738 -0.14990610248272754 -0.05609181457583507 50.0 1.8283946523280963 1.273419679713589 1.5258812970076288 1.4358146661745712 1.6989700043360187 0.2620699423986347 0.10497155726409971 0.18352074983136718 75.0 1.8283946523280963 1.273419679713589 1.5258812970076288 1.4358146661745712 1.8750612633917 0.2620699423986347 0.10497155726409971 0.18352074983136718 100.0 1.8283946523280963 1.273419679713589 1.5258812970076288 1.4358146661745712 2.0 0.2620699423986347 0.10497155726409971 0.18352074983136718 250.0 1.8283946523280963 1.273419679713589 1.5258812970076288 1.4358146661745712 2.3979400086720375 0.2620699423986347 0.10497155726409971 0.18352074983136718 500.0 1.8283946523280963 1.273419679713589 1.5258812970076288 1.4358146661745712 2.6989700043360187 0.2620699423986347 0.10497155726409971 0.18352074983136718 1000.0 1.8283946523280963 1.273419679713589 1.5258812970076288 1.4358146661745712 3.0 0.2620699423986347 0.10497155726409971 0.18352074983136718 2500.0 1.8283946523280963 1.273419679713589 1.5258812970076288 1.4358146661745712 3.3979400086720375 0.2620699423986347 0.10497155726409971 0.18352074983136718 5000.0 1.8283946523280963 1.273419679713589 1.5258812970076288 1.4358146661745712 3.6989700043360187 0.2620699423986347 0.10497155726409971 0.18352074983136718 10000.0 1.8283946523280963 1.273419679713589 1.5258812970076288 1.4358146661745712 4.0 0.2620699423986347 0.10497155726409971 0.18352074983136718 ==> phenytoin_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 2.3132061913484379e-07 1.292652688114865e-08 5.4682467038443874e-08 17.8950325374861 -6.0 -6.635785653967932 -7.888518146346808 -7.26215190015737 5e-06 1.1566030956742191e-06 6.463263440574326e-08 2.734123351922199e-07 17.8950325374861 -5.301029995663981 -5.936815649631912 -7.189548142010789 -6.563181895821351 1e-05 2.3132061913484383e-06 1.2926526881148653e-07 5.468246703844399e-07 17.8950325374861 -5.0 -5.635785653967931 -6.888518146346808 -6.262151900157369 5e-05 1.156603095674219e-05 6.463263440574327e-07 2.734123351922199e-06 17.895032537486095 -4.301029995663981 -4.936815649631912 -6.189548142010789 -5.563181895821351 0.0001 2.313206191348438e-05 1.2926526881148653e-06 5.468246703844388e-06 17.895032537486095 -4.0 -4.635785653967932 -5.888518146346808 -5.26215190015737 0.001 0.0002313206191348438 1.2926526881148653e-05 5.4682467038443986e-05 17.895032537486095 -3.0 -3.635785653967931 -4.888518146346808 -4.262151900157369 0.01 0.0023132061913484383 0.00012926526881148654 0.0005468246703844399 17.895032537486095 -2.0 -2.635785653967931 -3.888518146346808 -3.2621519001573693 0.1 0.02313206191348438 0.0012926526881148653 0.005468246703844393 17.895032537486095 -1.0 -1.6357856539679312 -2.8885181463468084 -2.2621519001573698 1.0 0.23132061913484378 0.01292652688114865 0.054682467038443934 17.8950325374861 0.0 -0.6357856539679313 -1.8885181463468084 -1.2621519001573698 10.0 1.954249250641207 0.1486661893199628 0.5390090806973674 13.145216539015651 1.0 0.2909799540985422 -0.8277877904651815 -0.26840391818331966 25.0 2.6819227680162694 0.346174953630577 0.9635426767190028 7.747304476794419 1.3979400086720377 0.4284462672115882 -0.4607043572969213 -0.01612904504266654 50.0 3.0806387632738477 0.6133608569456565 1.3746065734535298 5.0225552028449565 1.6989700043360187 0.48864077578706316 -0.21228394298498043 0.13817841640104134 75.0 3.0806387632738477 0.6133608569456565 1.3746065734535298 5.0225552028449565 1.8750612633917 0.48864077578706316 -0.21228394298498043 0.13817841640104134 100.0 3.0806387632738477 0.6133608569456565 1.3746065734535298 5.0225552028449565 2.0 0.48864077578706316 -0.21228394298498043 0.13817841640104134 250.0 3.0806387632738477 0.6133608569456565 1.3746065734535298 5.0225552028449565 2.3979400086720375 0.48864077578706316 -0.21228394298498043 0.13817841640104134 500.0 3.0806387632738477 0.6133608569456565 1.3746065734535298 5.0225552028449565 2.6989700043360187 0.48864077578706316 -0.21228394298498043 0.13817841640104134 1000.0 3.0806387632738477 0.6133608569456565 1.3746065734535298 5.0225552028449565 3.0 0.48864077578706316 -0.21228394298498043 0.13817841640104134 2500.0 3.0806387632738477 0.6133608569456565 1.3746065734535298 5.0225552028449565 3.3979400086720375 0.48864077578706316 -0.21228394298498043 0.13817841640104134 5000.0 3.0806387632738477 0.6133608569456565 1.3746065734535298 5.0225552028449565 3.6989700043360187 0.48864077578706316 -0.21228394298498043 0.13817841640104134 10000.0 3.0806387632738477 0.6133608569456565 1.3746065734535298 5.0225552028449565 4.0 0.48864077578706316 -0.21228394298498043 0.13817841640104134 ==> phenytoin_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 4.166612035947288e-08 2.3442279073950988e-08 3.125298100014777e-08 1.777392045715051 -6.0 -7.380216935945728 -7.630000168203212 -7.50510855207447 5e-06 2.0833060179736441e-07 1.1721139536975493e-07 1.562649050007388e-07 1.7773920457150514 -5.301029995663981 -6.681246931609709 -6.931030163867193 -6.806138547738451 1e-05 4.1666120359472883e-07 2.3442279073950986e-07 3.1252981000147765e-07 1.7773920457150514 -5.0 -6.380216935945728 -6.630000168203212 -6.50510855207447 5e-05 2.083306017973644e-06 1.1721139536975495e-06 1.5626490500073882e-06 1.7773920457150512 -4.301029995663981 -5.681246931609709 -5.931030163867193 -5.806138547738451 0.0001 4.166612035947288e-06 2.344227907395099e-06 3.1252981000147768e-06 1.7773920457150512 -4.0 -5.380216935945728 -5.630000168203212 -5.50510855207447 0.001 4.1666120359472874e-05 2.3442279073950994e-05 3.1252981000147765e-05 1.7773920457150503 -3.0 -4.380216935945728 -4.630000168203212 -4.50510855207447 0.01 0.0004166612035947288 0.00023442279073950987 0.000312529810001477 1.7773920457150512 -2.0 -3.3802169359457284 -3.630000168203212 -3.5051085520744705 0.1 0.004166612035947288 0.0023442279073950995 0.00312529810001477 1.7773920457150505 -1.0 -2.3802169359457284 -2.630000168203212 -2.5051085520744705 1.0 0.041666120359472876 0.023442279073950988 0.03125298100014772 1.777392045715051 0.0 -1.3802169359457281 -1.6300001682032124 -1.5051085520744703 10.0 0.4711690680680567 0.27298498516394004 0.3586392073606369 1.7259889505831172 1.0 -0.32682322842532713 -0.5638612395518293 -0.4453422339885782 25.0 1.0572876324637357 0.6496805149206145 0.8287938063705818 1.627396248128093 1.3979400086720377 0.02419315211212857 -0.1873001583067484 -0.08155350309730988 50.0 1.7928181715691758 1.1864243756836415 1.4584386102672429 1.5111103651559064 1.6989700043360187 0.2535362454526104 0.07424006090986347 0.1638881531812369 75.0 1.7928181715691758 1.1864243756836415 1.4584386102672429 1.5111103651559064 1.8750612633917 0.2535362454526104 0.07424006090986347 0.1638881531812369 100.0 1.7928181715691758 1.1864243756836415 1.4584386102672429 1.5111103651559064 2.0 0.2535362454526104 0.07424006090986347 0.1638881531812369 250.0 1.7928181715691758 1.1864243756836415 1.4584386102672429 1.5111103651559064 2.3979400086720375 0.2535362454526104 0.07424006090986347 0.1638881531812369 500.0 1.7928181715691758 1.1864243756836415 1.4584386102672429 1.5111103651559064 2.6989700043360187 0.2535362454526104 0.07424006090986347 0.1638881531812369 1000.0 1.7928181715691758 1.1864243756836415 1.4584386102672429 1.5111103651559064 3.0 0.2535362454526104 0.07424006090986347 0.1638881531812369 2500.0 1.7928181715691758 1.1864243756836415 1.4584386102672429 1.5111103651559064 3.3979400086720375 0.2535362454526104 0.07424006090986347 0.1638881531812369 5000.0 1.7928181715691758 1.1864243756836415 1.4584386102672429 1.5111103651559064 3.6989700043360187 0.2535362454526104 0.07424006090986347 0.1638881531812369 10000.0 1.7928181715691758 1.1864243756836415 1.4584386102672429 1.5111103651559064 4.0 0.2535362454526104 0.07424006090986347 0.1638881531812369 ==> phenytoin_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 5.311973327920117e-08 2.0015764705458067e-08 3.2607239725759953e-08 2.6538947704913833 -6.0 -7.274744114281265 -7.6986278129525045 -7.486685963616885 5e-06 2.6559866639600593e-07 1.0007882352729037e-07 1.630361986288001e-07 2.6538947704913833 -5.301029995663981 -6.575774109945247 -6.999657808616485 -6.787715959280866 1e-05 5.311973327920119e-07 2.0015764705458074e-07 3.260723972575996e-07 2.6538947704913833 -5.0 -6.274744114281265 -6.6986278129525045 -6.486685963616885 5e-05 2.655986663960059e-06 1.0007882352729036e-06 1.630361986288001e-06 2.6538947704913833 -4.301029995663981 -5.575774109945247 -5.999657808616485 -5.787715959280866 0.0001 5.311973327920118e-06 2.0015764705458073e-06 3.2607239725760024e-06 2.6538947704913833 -4.0 -5.274744114281265 -5.698627812952504 -5.4866859636168845 0.001 5.3119733279201185e-05 2.0015764705458075e-05 3.260723972576002e-05 2.653894770491383 -3.0 -4.274744114281265 -4.698627812952504 -4.4866859636168845 0.01 0.0005311973327920119 0.00020015764705458075 0.00032607239725760025 2.6538947704913833 -2.0 -3.2747441142812654 -3.698627812952504 -3.4866859636168845 0.1 0.0053119733279201175 0.0020015764705458073 0.0032607239725760025 2.653894770491383 -1.0 -2.2747441142812654 -2.698627812952504 -2.4866859636168845 1.0 0.053119733279201185 0.02001576470545807 0.032607239725760025 2.653894770491384 0.0 -1.2747441142812652 -1.698627812952504 -1.4866859636168845 10.0 0.5909884546039814 0.2331559876145294 0.3712041174367221 2.5347341951219664 1.0 -0.228421003299386 -0.6323534270696235 -0.43038721518450473 25.0 1.2774019830825418 0.5562903394077089 0.8429747224733773 2.2962864759481745 1.3979400086720377 0.1063275860361016 -0.25469848199401623 -0.07418544797895732 50.0 2.0682545422243632 1.024024047271095 1.455315219158866 2.0197323956756885 1.6989700043360187 0.31560398678198737 0.01031015534539436 0.16295707106369087 75.0 2.0682545422243632 1.024024047271095 1.455315219158866 2.0197323956756885 1.8750612633917 0.31560398678198737 0.01031015534539436 0.16295707106369087 100.0 2.0682545422243632 1.024024047271095 1.455315219158866 2.0197323956756885 2.0 0.31560398678198737 0.01031015534539436 0.16295707106369087 250.0 2.0682545422243632 1.024024047271095 1.455315219158866 2.0197323956756885 2.3979400086720375 0.31560398678198737 0.01031015534539436 0.16295707106369087 500.0 2.0682545422243632 1.024024047271095 1.455315219158866 2.0197323956756885 2.6989700043360187 0.31560398678198737 0.01031015534539436 0.16295707106369087 1000.0 2.0682545422243632 1.024024047271095 1.455315219158866 2.0197323956756885 3.0 0.31560398678198737 0.01031015534539436 0.16295707106369087 2500.0 2.0682545422243632 1.024024047271095 1.455315219158866 2.0197323956756885 3.3979400086720375 0.31560398678198737 0.01031015534539436 0.16295707106369087 5000.0 2.0682545422243632 1.024024047271095 1.455315219158866 2.0197323956756885 3.6989700043360187 0.31560398678198737 0.01031015534539436 0.16295707106369087 10000.0 2.0682545422243632 1.024024047271095 1.455315219158866 2.0197323956756885 4.0 0.31560398678198737 0.01031015534539436 0.16295707106369087 ==> pindolol_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.0599226843758406e-08 9.901555312421574e-11 1.02444536634404e-09 107.04608023005838 -6.0 -7.974725813012178 -10.004296582114627 -8.989511197563402 5e-06 5.299613421879204e-08 4.950777656210787e-10 5.122226831720199e-09 107.0460802300584 -5.301029995663981 -7.275755808676159 -9.305326577778608 -8.290541193227384 1e-05 1.0599226843758408e-07 9.901555312421574e-10 1.02444536634404e-08 107.0460802300584 -5.0 -6.974725813012178 -9.004296582114627 -7.989511197563402 5e-05 5.299613421879204e-07 4.950777656210787e-09 5.1222268317201987e-08 107.04608023005841 -4.301029995663981 -6.275755808676159 -8.305326577778608 -7.290541193227384 0.0001 1.0599226843758407e-06 9.901555312421573e-09 1.0244453663440399e-07 107.04608023005841 -4.0 -5.974725813012178 -8.004296582114627 -6.989511197563402 0.001 1.0599226843758407e-05 9.901555312421576e-08 1.02444536634404e-06 107.04608023005837 -3.0 -4.974725813012178 -7.004296582114627 -5.989511197563402 0.01 0.00010599226843758408 9.901555312421574e-07 1.0244453663440399e-05 107.0460802300584 -2.0 -3.974725813012178 -6.004296582114627 -4.989511197563402 0.1 0.0010599226843758405 9.901555312421576e-06 0.000102444536634404 107.04608023005835 -1.0 -2.974725813012178 -5.004296582114627 -3.9895111975634023 1.0 0.010599226843758407 9.901555312421575e-05 0.0010244453663440399 107.04608023005838 0.0 -1.9747258130121779 -4.004296582114627 -2.9895111975634023 10.0 0.10599226843758407 0.0009901555312421574 0.010244453663440399 107.0460802300584 1.0 -0.974725813012178 -3.004296582114627 -1.9895111975634023 25.0 0.2649806710939602 0.002475388828105394 0.02561113415860099 107.04608023005837 1.3979400086720377 -0.5767858043401403 -2.6063565734425893 -1.5915711888913648 50.0 0.5299613421879203 0.004950777656210788 0.05122226831720199 107.04608023005837 1.6989700043360187 -0.27575580867615906 -2.305326577778608 -1.2905411932273836 75.0 0.7949420132818806 0.0074261664843161814 0.076833402475803 107.0460802300584 1.8750612633917 -0.09966454962047781 -2.1292353187229267 -1.1144499341717022 100.0 1.0599226843758407 0.009901555312421576 0.10244453663440399 107.04608023005837 2.0 0.025274186987822075 -2.004296582114627 -0.9895111975634023 250.0 2.6498067109396017 0.024753888281053932 0.2561113415860099 107.04608023005841 2.3979400086720375 0.4232141956598597 -1.6063565734425893 -0.5915711888913648 500.0 5.2996134218792035 0.049507776562107864 0.5122226831720199 107.04608023005841 2.6989700043360187 0.7242441913238409 -1.305326577778608 -0.29054119322738353 1000.0 10.599226843758407 0.09901555312421573 1.0244453663440398 107.04608023005841 3.0 1.0252741869878221 -1.0042965821146268 0.010488802436597625 2500.0 26.49806710939602 0.2475388828105393 2.561113415860099 107.04608023005842 3.3979400086720375 1.4232141956598596 -0.6063565734425893 0.40842881110863516 5000.0 70.10245549715036 0.9172132516313619 8.018659560916905 76.42983283600148 3.6989700043360187 1.845733230380151 -0.037529679335903364 0.9041017755221238 10000.0 97.73698529717616 1.4595796033325377 11.94382309945063 66.96242197001203 4.0 1.990058939060958 0.16422778575453084 1.0771433624077444 ==> pindolol_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 8.472707478963416e-09 9.817440158067868e-11 9.120323385249959e-10 86.30261394565909 -6.0 -8.07197778739284 -10.008001737279354 -9.039989762336097 5e-06 4.2363537394817094e-08 4.908720079033936e-10 4.5601616926249795e-09 86.30261394565908 -5.301029995663981 -7.37300778305682 -9.309031732943335 -8.341019758000078 1e-05 8.472707478963419e-08 9.817440158067873e-10 9.120323385249959e-09 86.30261394565908 -5.0 -7.071977787392838 -9.008001737279354 -8.039989762336097 5e-05 4.2363537394817085e-07 4.908720079033936e-09 4.5601616926249795e-08 86.30261394565908 -4.301029995663981 -6.37300778305682 -8.309031732943335 -7.341019758000078 0.0001 8.472707478963417e-07 9.817440158067871e-09 9.12032338524996e-08 86.30261394565908 -4.0 -6.071977787392838 -8.008001737279354 -7.039989762336097 0.001 8.472707478963417e-06 9.81744015806787e-08 9.12032338524996e-07 86.30261394565908 -3.0 -5.071977787392838 -7.008001737279354 -6.039989762336097 0.01 8.472707478963418e-05 9.817440158067872e-07 9.12032338524996e-06 86.30261394565908 -2.0 -4.071977787392838 -6.008001737279354 -5.039989762336097 0.1 0.0008472707478963419 9.81744015806787e-06 9.12032338524996e-05 86.3026139456591 -1.0 -3.0719777873928384 -5.008001737279354 -4.039989762336097 1.0 0.008472707478963417 9.817440158067869e-05 0.0009120323385249959 86.30261394565909 0.0 -2.071977787392839 -4.008001737279354 -3.0399897623360967 10.0 0.08472707478963418 0.000981744015806787 0.009120323385249969 86.30261394565909 1.0 -1.0719777873928387 -3.008001737279354 -2.0399897623360963 25.0 0.2118176869740854 0.002454360039516967 0.022800808463124916 86.30261394565909 1.3979400086720377 -0.6740377787208012 -2.6100617286073167 -1.6420497536640588 50.0 0.4236353739481708 0.004908720079033934 0.04560161692624982 86.30261394565909 1.6989700043360187 -0.37300778305682 -2.3090317329433354 -1.3410197580000778 75.0 0.6354530609222564 0.007363080118550903 0.06840242538937474 86.3026139456591 1.8750612633917 -0.1969165240011386 -2.132940473887654 -1.1649284989443964 100.0 0.8472707478963416 0.009817440158067868 0.09120323385249965 86.30261394565909 2.0 -0.07197778739283878 -2.008001737279354 -1.0399897623360965 250.0 2.1181768697408536 0.024543600395169674 0.22800808463124916 86.30261394565906 2.3979400086720375 0.32596222127919877 -1.6100617286073164 -0.6420497536640588 500.0 4.236353739481707 0.04908720079033935 0.4560161692624983 86.30261394565906 2.6989700043360187 0.62699221694318 -1.3090317329433352 -0.3410197580000776 1000.0 8.472707478963414 0.0981744015806787 0.9120323385249967 86.30261394565906 3.0 0.9280222126071611 -1.008001737279354 -0.03998976233609642 2500.0 21.181768697408543 0.24543600395169676 2.280080846312492 86.30261394565909 3.3979400086720375 1.3259622212791988 -0.6100617286073163 0.35795024633594125 5000.0 74.20137337417474 0.909421391483934 8.214640358771705 81.59184957492347 3.6989700043360187 1.8704119435985134 -0.04123483450063907 0.9145885545489372 10000.0 108.80859824552489 1.4471802620420222 12.548532014597722 75.18662401599656 4.0 2.036663215426879 0.1605226305898098 1.0985929230083444 ==> pindolol_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.964715628309682e-08 2.0992896463361258e-10 2.030888272777526e-09 93.58954500341034 -6.0 -7.706700300246934 -9.677927636154562 -8.692313968200748 5e-06 9.823578141548412e-08 1.0496448231680632e-09 1.0154441363887627e-08 93.58954500341032 -5.301029995663981 -7.007730295910915 -8.978957631818544 -7.99334396386473 1e-05 1.9647156283096824e-07 2.0992896463361263e-09 2.0308882727775257e-08 93.58954500341032 -5.0 -6.706700300246934 -8.677927636154562 -7.692313968200748 5e-05 9.823578141548412e-07 1.0496448231680631e-08 1.0154441363887648e-07 93.58954500341034 -4.301029995663981 -6.007730295910915 -7.978957631818543 -6.993343963864729 0.0001 1.9647156283096824e-06 2.0992896463361262e-08 2.03088827277753e-07 93.58954500341034 -4.0 -5.706700300246934 -7.677927636154561 -6.6923139682007475 0.001 1.9647156283096822e-05 2.0992896463361265e-07 2.03088827277753e-06 93.58954500341031 -3.0 -4.706700300246934 -6.677927636154561 -5.6923139682007475 0.01 0.00019647156283096826 2.099289646336126e-06 2.0308882727775257e-05 93.58954500341035 -2.0 -3.7067003002469336 -5.677927636154562 -4.692313968200748 0.1 0.0019647156283096826 2.0992896463361262e-05 0.00020308882727775298 93.58954500341034 -1.0 -2.7067003002469336 -4.677927636154561 -3.6923139682007475 1.0 0.019647156283096826 0.0002099289646336126 0.002030888272777528 93.58954500341035 0.0 -1.7067003002469339 -3.677927636154562 -2.692313968200748 10.0 0.19647156283096823 0.0020992896463361264 0.020308882727775278 93.58954500341032 1.0 -0.7067003002469339 -2.677927636154562 -1.692313968200748 25.0 0.49117890707742057 0.005248224115840316 0.050772206819438205 93.58954500341032 1.3979400086720377 -0.30876029157489626 -2.2799876274825244 -1.2943739595287103 50.0 0.9823578141548411 0.010496448231680632 0.10154441363887642 93.58954500341032 1.6989700043360187 -0.007730295910915053 -1.978957631818543 -0.993343963864729 75.0 1.4735367212322616 0.015744672347520944 0.15231662045831465 93.58954500341034 1.8750612633917 0.16836096314476617 -1.8028663727628618 -0.8172527048090478 100.0 1.9647156283096823 0.020992896463361263 0.20308882727775282 93.58954500341032 2.0 0.29329969975306613 -1.6779276361545619 -0.6923139682007479 250.0 4.911789070774206 0.05248224115840316 0.5077220681943821 93.58954500341032 2.3979400086720375 0.6912397084251037 -1.2799876274825241 -0.2943739595287102 500.0 9.823578141548412 0.10496448231680632 1.0154441363887643 93.58954500341032 2.6989700043360187 0.992269704089085 -0.978957631818543 0.006656036135270997 1000.0 19.647156283096823 0.20992896463361263 2.0308882727775286 93.58954500341032 3.0 1.2932996997530661 -0.6779276361545618 0.3076860317992522 2500.0 49.117890707742056 0.5248224115840314 5.077220681943819 93.58954500341035 3.3979400086720375 1.6912397084251036 -0.2799876274825243 0.7056260404712896 5000.0 213.68900524601747 1.9298429625741536 20.30729482115967 110.72870144883954 3.6989700043360187 2.3297821773637732 0.2855219705299153 1.3076520739468442 10000.0 298.30865681590353 3.033455137366555 30.081654335144513 98.33956439351708 4.0 2.474665856623296 0.48193757642256835 1.4783017165229322 ==> pindolol_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.0464117908155721e-08 1.6705160674405327e-10 1.3221375532510363e-09 62.64003149750144 -6.0 -7.980297375425303 -9.777149342853026 -8.878723359139164 5e-06 5.2320589540778604e-08 8.352580337202665e-10 6.610687766255181e-09 62.640031497501425 -5.301029995663981 -7.281327371089284 -9.078179338517007 -8.179753354803145 1e-05 1.0464117908155721e-07 1.670516067440533e-09 1.3221375532510364e-08 62.640031497501425 -5.0 -6.980297375425303 -8.777149342853026 -7.878723359139164 5e-05 5.23205895407786e-07 8.352580337202665e-09 6.61068776625518e-08 62.640031497501425 -4.301029995663981 -6.281327371089284 -8.078179338517007 -7.179753354803145 0.0001 1.046411790815572e-06 1.670516067440533e-08 1.3221375532510364e-07 62.640031497501425 -4.0 -5.980297375425303 -7.777149342853026 -6.878723359139164 0.001 1.046411790815572e-05 1.670516067440533e-07 1.3221375532510364e-06 62.640031497501425 -3.0 -4.980297375425303 -6.777149342853026 -5.878723359139164 0.01 0.00010464117908155722 1.6705160674405326e-06 1.3221375532510364e-05 62.64003149750145 -2.0 -3.9802973754253026 -5.777149342853026 -4.878723359139164 0.1 0.001046411790815572 1.6705160674405333e-05 0.00013221375532510363 62.64003149750141 -1.0 -2.9802973754253026 -4.777149342853025 -3.8787233591391637 1.0 0.01046411790815572 0.00016705160674405328 0.0013221375532510365 62.640031497501425 0.0 -1.9802973754253026 -3.777149342853025 -2.8787233591391637 10.0 0.1046411790815572 0.001670516067440533 0.013221375532510357 62.64003149750143 1.0 -0.9802973754253026 -2.777149342853025 -1.8787233591391639 25.0 0.26160294770389303 0.004176290168601333 0.0330534388312759 62.64003149750143 1.3979400086720377 -0.5823573667532649 -2.3792093341809877 -1.4807833504671262 50.0 0.5232058954077861 0.008352580337202665 0.06610687766255177 62.64003149750143 1.6989700043360187 -0.28132737108928374 -2.0781793385170064 -1.1797533548031451 75.0 0.7848088431116792 0.012528870505803997 0.09916031649382769 62.64003149750144 1.8750612633917 -0.10523611203360246 -1.902088079461325 -1.0036620957474638 100.0 1.0464117908155721 0.01670516067440533 0.13221375532510357 62.64003149750143 2.0 0.019702624574697427 -1.7771493428530252 -0.8787233591391639 250.0 2.6160294770389303 0.04176290168601333 0.33053438831275894 62.640031497501425 2.3979400086720375 0.41764263324673506 -1.3792093341809877 -0.4807833504671263 500.0 5.232058954077861 0.08352580337202666 0.6610687766255179 62.640031497501425 2.6989700043360187 0.7186726289107163 -1.0781793385170064 -0.17975335480314505 1000.0 10.464117908155721 0.1670516067440533 1.3221375532510358 62.640031497501425 3.0 1.0197026245746974 -0.7771493428530252 0.12127664086083613 2500.0 26.160294770389303 0.4176290168601332 3.3053438831275894 62.64003149750144 3.3979400086720375 1.4176426332467351 -0.3792093341809877 0.5192166495328737 5000.0 91.49869332310281 1.5356901978657092 11.85384521806361 59.58147903155664 3.6989700043360187 1.9614148920269059 0.18630361222691807 1.073859252126912 10000.0 142.72726577335013 2.4139322507286614 18.561625734525812 59.12645880192659 4.0 2.154506946091421 0.3827250770506488 1.2686160115710348 ==> pindolol_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.4553223937231512e-08 1.64653053639813e-10 1.5479769899999132e-09 88.38720944141998 -6.0 -7.837040787911493 -9.783430210493385 -8.81023549920244 5e-06 7.276611968615757e-08 8.232652681990651e-10 7.739884949999566e-09 88.38720944142 -5.301029995663981 -7.138070783575475 -9.084460206157367 -8.111265494866421 1e-05 1.4553223937231513e-07 1.6465305363981301e-09 1.547976989999913e-08 88.38720944142 -5.0 -6.837040787911493 -8.783430210493385 -7.81023549920244 5e-05 7.276611968615756e-07 8.23265268199065e-09 7.739884949999565e-08 88.38720944142 -4.301029995663981 -6.138070783575475 -8.084460206157367 -7.111265494866421 0.0001 1.4553223937231513e-06 1.64653053639813e-08 1.5479769899999132e-07 88.38720944142 -4.0 -5.837040787911493 -7.783430210493386 -6.81023549920244 0.001 1.4553223937231512e-05 1.6465305363981303e-07 1.5479769899999132e-06 88.38720944141997 -3.0 -4.837040787911493 -6.783430210493386 -5.81023549920244 0.01 0.00014553223937231513 1.64653053639813e-06 1.5479769899999133e-05 88.38720944142 -2.0 -3.8370407879114934 -5.783430210493386 -4.81023549920244 0.1 0.0014553223937231513 1.64653053639813e-05 0.00015479769899999133 88.38720944142 -1.0 -2.8370407879114934 -4.783430210493386 -3.81023549920244 1.0 0.014553223937231512 0.00016465305363981298 0.0015479769899999132 88.38720944142 0.0 -1.8370407879114936 -3.7834302104933863 -2.81023549920244 10.0 0.1455322393723151 0.00164653053639813 0.015479769899999133 88.38720944141998 1.0 -0.8370407879114936 -2.7834302104933863 -1.8102354992024399 25.0 0.36383059843078774 0.004116326340995325 0.038699424749997824 88.38720944141998 1.3979400086720377 -0.43910077923945606 -2.385490201821349 -1.4122954905304024 50.0 0.7276611968615755 0.00823265268199065 0.07739884949999565 88.38720944141998 1.6989700043360187 -0.13807078357547486 -2.0844602061573676 -1.1112654948664211 75.0 1.0914917952923635 0.012348979022985972 0.11609827424999347 88.38720944142003 1.8750612633917 0.03802047548020648 -1.9083689471016863 -0.9351742358107399 100.0 1.455322393723151 0.0164653053639813 0.1547976989999913 88.38720944141998 2.0 0.1629592120885063 -1.7834302104933863 -0.81023549920244 250.0 3.6383059843078778 0.04116326340995325 0.3869942474999782 88.38720944141998 2.3979400086720375 0.5608992207605439 -1.3854902018213486 -0.4122954905304024 500.0 7.2766119686157555 0.0823265268199065 0.7739884949999564 88.38720944141998 2.6989700043360187 0.8619292164245251 -1.0844602061573676 -0.1112654948664212 1000.0 14.553223937231511 0.164653053639813 1.547976989999913 88.38720944141998 3.0 1.1629592120885064 -0.7834302104933863 0.18976450079756005 2500.0 36.38305984307878 0.4116326340995325 3.869942474999783 88.38720944142 3.3979400086720375 1.560899220760544 -0.3854902018213487 0.5877045094695977 5000.0 129.97106383871918 1.5177228044409907 14.044929601300247 85.63557420262276 3.6989700043360187 2.1138466737377835 0.18119245963951663 1.14751956668865 10000.0 171.75913839161723 2.396023010486185 20.28642028174503 71.68509552701042 4.0 2.234919852849334 0.37949098453496566 1.3072054186921498 ==> prazosin_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.2138979707357276e-08 2.1051337567341885e-10 1.5985673571754518e-09 57.663697940928714 -6.0 -7.915817814585798 -9.676720304595024 -8.796269059590411 5e-06 6.069489853678638e-08 1.0525668783670944e-09 7.992836785877258e-09 57.663697940928714 -5.301029995663981 -7.216847810249779 -8.977750300259006 -8.097299055254393 1e-05 1.2138979707357276e-07 2.1051337567341887e-09 1.598567357175452e-08 57.663697940928714 -5.0 -6.915817814585798 -8.676720304595024 -7.796269059590411 5e-05 6.069489853678638e-07 1.0525668783670943e-08 7.992836785877258e-08 57.66369794092871 -4.301029995663981 -6.216847810249779 -7.977750300259006 -7.097299055254393 0.0001 1.2138979707357275e-06 2.1051337567341886e-08 1.5985673571754519e-07 57.66369794092871 -4.0 -5.915817814585798 -7.676720304595025 -6.796269059590411 0.001 1.2138979707357276e-05 2.105133756734188e-07 1.5985673571754518e-06 57.66369794092873 -3.0 -4.915817814585798 -6.676720304595025 -5.796269059590411 0.01 0.00012138979707357275 2.1051337567341883e-06 1.598567357175452e-05 57.66369794092872 -2.0 -3.9158178145857976 -5.676720304595025 -4.796269059590411 0.1 0.0012138979707357277 2.105133756734189e-05 0.00015985673571754518 57.663697940928714 -1.0 -2.915817814585797 -4.676720304595025 -3.7962690595904114 1.0 0.021408561856377597 0.00039518427394812805 0.0029086641218068077 54.173617898539376 0.0 -1.6694125059338323 -3.4032003461528313 -2.536306426043332 10.0 0.07811464988383328 0.00420189134971403 0.018117098874621707 18.590354529074048 1.0 -1.1072675094381608 -2.376555181542086 -1.7419113454901234 25.0 0.07997491611010156 0.004258319709780687 0.01845423424473914 18.78086230266173 1.3979400086720377 -1.0970462067979545 -2.370761735339887 -1.7339039710689208 50.0 0.07997491611010156 0.004258319709780687 0.01845423424473914 18.78086230266173 1.6989700043360187 -1.0970462067979545 -2.370761735339887 -1.7339039710689208 75.0 0.07997491611010156 0.004258319709780687 0.01845423424473914 18.78086230266173 1.8750612633917 -1.0970462067979545 -2.370761735339887 -1.7339039710689208 100.0 0.07997491611010156 0.004258319709780687 0.01845423424473914 18.78086230266173 2.0 -1.0970462067979545 -2.370761735339887 -1.7339039710689208 250.0 0.07997491611010156 0.004258319709780687 0.01845423424473914 18.78086230266173 2.3979400086720375 -1.0970462067979545 -2.370761735339887 -1.7339039710689208 500.0 0.07997491611010156 0.004258319709780687 0.01845423424473914 18.78086230266173 2.6989700043360187 -1.0970462067979545 -2.370761735339887 -1.7339039710689208 1000.0 0.07997491611010156 0.004258319709780687 0.01845423424473914 18.78086230266173 3.0 -1.0970462067979545 -2.370761735339887 -1.7339039710689208 2500.0 0.07997491611010156 0.004258319709780687 0.01845423424473914 18.78086230266173 3.3979400086720375 -1.0970462067979545 -2.370761735339887 -1.7339039710689208 5000.0 0.07997491611010156 0.004258319709780687 0.01845423424473914 18.78086230266173 3.6989700043360187 -1.0970462067979545 -2.370761735339887 -1.7339039710689208 10000.0 0.07997491611010156 0.004258319709780687 0.01845423424473914 18.78086230266173 4.0 -1.0970462067979545 -2.370761735339887 -1.7339039710689208 ==> prazosin_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.3240321759632767e-08 2.0868210784172912e-10 1.6622329118697153e-09 63.44732615828584 -6.0 -7.878101460762251 -9.680514785235994 -8.779308122999122 5e-06 6.620160879816384e-08 1.0434105392086458e-09 8.311164559348576e-09 63.44732615828583 -5.301029995663981 -7.179131456426231 -8.981544780899975 -8.080338118663104 1e-05 1.3240321759632768e-07 2.0868210784172915e-09 1.6622329118697153e-08 63.44732615828583 -5.0 -6.878101460762251 -8.680514785235994 -7.779308122999122 5e-05 6.620160879816384e-07 1.0434105392086454e-08 8.311164559348575e-08 63.44732615828586 -4.301029995663981 -6.179131456426231 -7.981544780899975 -7.080338118663104 0.0001 1.3240321759632769e-06 2.0868210784172908e-08 1.6622329118697153e-07 63.44732615828586 -4.0 -5.87810146076225 -7.680514785235994 -6.779308122999122 0.001 1.3240321759632769e-05 2.0868210784172915e-07 1.6622329118697154e-06 63.44732615828584 -3.0 -4.87810146076225 -6.680514785235994 -5.779308122999122 0.01 0.0001324032175963277 2.0868210784172913e-06 1.6622329118697154e-05 63.44732615828585 -2.0 -3.87810146076225 -5.680514785235994 -4.779308122999122 0.1 0.0013240321759632769 2.0868210784172916e-05 0.00016622329118697155 63.44732615828584 -1.0 -2.87810146076225 -4.680514785235994 -3.7793081229991223 1.0 0.023226635391657275 0.0003917465434658922 0.0030164472697238208 59.2899561695291 0.0 -1.6340136975036297 -3.4069948267938 -2.520504262148715 10.0 0.07831880506672813 0.004165338857805308 0.018061682148718092 18.802505087903903 1.0 -1.106133947314279 -2.3803496621830513 -1.7432418047486653 25.0 0.08016288969722175 0.00422127634435738 0.01839537197161862 18.99020181523445 1.3979400086720377 -1.096026635826407 -2.3745562159808524 -1.7352914259036298 50.0 0.08016288969722175 0.00422127634435738 0.01839537197161862 18.99020181523445 1.6989700043360187 -1.096026635826407 -2.3745562159808524 -1.7352914259036298 75.0 0.08016288969722175 0.00422127634435738 0.01839537197161862 18.99020181523445 1.8750612633917 -1.096026635826407 -2.3745562159808524 -1.7352914259036298 100.0 0.08016288969722175 0.00422127634435738 0.01839537197161862 18.99020181523445 2.0 -1.096026635826407 -2.3745562159808524 -1.7352914259036298 250.0 0.08016288969722175 0.00422127634435738 0.01839537197161862 18.99020181523445 2.3979400086720375 -1.096026635826407 -2.3745562159808524 -1.7352914259036298 500.0 0.08016288969722175 0.00422127634435738 0.01839537197161862 18.99020181523445 2.6989700043360187 -1.096026635826407 -2.3745562159808524 -1.7352914259036298 1000.0 0.08016288969722175 0.00422127634435738 0.01839537197161862 18.99020181523445 3.0 -1.096026635826407 -2.3745562159808524 -1.7352914259036298 2500.0 0.08016288969722175 0.00422127634435738 0.01839537197161862 18.99020181523445 3.3979400086720375 -1.096026635826407 -2.3745562159808524 -1.7352914259036298 5000.0 0.08016288969722175 0.00422127634435738 0.01839537197161862 18.99020181523445 3.6989700043360187 -1.096026635826407 -2.3745562159808524 -1.7352914259036298 10000.0 0.08016288969722175 0.00422127634435738 0.01839537197161862 18.99020181523445 4.0 -1.096026635826407 -2.3745562159808524 -1.7352914259036298 ==> prazosin_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 3.5911915893329035e-08 4.328601209608354e-10 3.942694035494222e-09 82.96425139283805 -6.0 -7.444761424734546 -9.36365242352949 -8.40420692413202 5e-06 1.795595794666452e-07 2.164300604804177e-09 1.9713470177471147e-08 82.96425139283805 -5.301029995663981 -6.745791420398527 -8.664682419193472 -7.705236919796 1e-05 3.591191589332904e-07 4.328601209608354e-09 3.94269403549423e-08 82.96425139283805 -5.0 -6.444761424734546 -8.36365242352949 -7.404206924132018 5e-05 1.7955957946664517e-06 2.1643006048041772e-08 1.9713470177471147e-07 82.96425139283804 -4.301029995663981 -5.745791420398527 -7.664682419193472 -6.705236919796 0.0001 3.5911915893329033e-06 4.3286012096083545e-08 3.942694035494222e-07 82.96425139283804 -4.0 -5.444761424734547 -7.363652423529491 -6.404206924132019 0.001 3.591191589332904e-05 4.3286012096083546e-07 3.94269403549423e-06 82.96425139283805 -3.0 -4.444761424734546 -6.363652423529491 -5.404206924132018 0.01 0.0003591191589332904 4.328601209608355e-06 3.94269403549423e-05 82.96425139283804 -2.0 -3.4447614247345464 -5.363652423529491 -4.404206924132018 0.1 0.003591191589332904 4.328601209608354e-05 0.000394269403549423 82.96425139283807 -1.0 -2.4447614247345464 -4.363652423529491 -3.4042069241320183 1.0 0.053130380673400784 0.0007984370553630452 0.006513160883563965 66.54297958308395 0.0 -1.2746570724063724 -3.097759315700828 -2.1862081940536005 10.0 0.08046720429162127 0.00630185640738752 0.022518720366613065 12.768809552260098 1.0 -1.0943810873000333 -2.2005314967808247 -1.647456292040429 25.0 0.08142804105386264 0.006367434480512115 0.022770325344336234 12.788202423295859 1.3979400086720377 -1.089226013073198 -2.196035515135206 -1.642630764104202 50.0 0.08142804105386264 0.006367434480512115 0.022770325344336234 12.788202423295859 1.6989700043360187 -1.089226013073198 -2.196035515135206 -1.642630764104202 75.0 0.08142804105386264 0.006367434480512115 0.022770325344336234 12.788202423295859 1.8750612633917 -1.089226013073198 -2.196035515135206 -1.642630764104202 100.0 0.08142804105386264 0.006367434480512115 0.022770325344336234 12.788202423295859 2.0 -1.089226013073198 -2.196035515135206 -1.642630764104202 250.0 0.08142804105386264 0.006367434480512115 0.022770325344336234 12.788202423295859 2.3979400086720375 -1.089226013073198 -2.196035515135206 -1.642630764104202 500.0 0.08142804105386264 0.006367434480512115 0.022770325344336234 12.788202423295859 2.6989700043360187 -1.089226013073198 -2.196035515135206 -1.642630764104202 1000.0 0.08142804105386264 0.006367434480512115 0.022770325344336234 12.788202423295859 3.0 -1.089226013073198 -2.196035515135206 -1.642630764104202 2500.0 0.08142804105386264 0.006367434480512115 0.022770325344336234 12.788202423295859 3.3979400086720375 -1.089226013073198 -2.196035515135206 -1.642630764104202 5000.0 0.08142804105386264 0.006367434480512115 0.022770325344336234 12.788202423295859 3.6989700043360187 -1.089226013073198 -2.196035515135206 -1.642630764104202 10000.0 0.08142804105386264 0.006367434480512115 0.022770325344336234 12.788202423295859 4.0 -1.089226013073198 -2.196035515135206 -1.642630764104202 ==> prazosin_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.7348359680697596e-08 3.432253884564954e-10 2.4401634147102634e-09 50.54509446027341 -6.0 -7.760741582273628 -9.464420594778025 -8.612581088525825 5e-06 8.674179840348801e-08 1.7161269422824769e-09 1.2200817073551291e-08 50.54509446027344 -5.301029995663981 -7.061771577937609 -8.765450590442006 -7.9136110841898075 1e-05 1.7348359680697603e-07 3.4322538845649537e-09 2.4401634147102586e-08 50.54509446027344 -5.0 -6.760741582273628 -8.464420594778025 -7.612581088525826 5e-05 8.674179840348799e-07 1.7161269422824766e-08 1.220081707355129e-07 50.54509446027343 -4.301029995663981 -6.061771577937609 -7.765450590442006 -6.9136110841898075 0.0001 1.7348359680697599e-06 3.432253884564953e-08 2.4401634147102586e-07 50.54509446027343 -4.0 -5.760741582273628 -7.464420594778025 -6.612581088525826 0.001 1.73483596806976e-05 3.4322538845649537e-07 2.4401634147102583e-06 50.54509446027343 -3.0 -4.760741582273628 -6.464420594778025 -5.612581088525826 0.01 0.000173483596806976 3.4322538845649538e-06 2.4401634147102586e-05 50.54509446027343 -2.0 -3.760741582273628 -5.464420594778025 -4.612581088525826 0.1 0.00173483596806976 3.432253884564954e-05 0.00024401634147102586 50.54509446027343 -1.0 -2.760741582273628 -4.464420594778025 -3.6125810885258263 1.0 0.030240871189690502 0.000633119949602524 0.0043756255374007135 47.76483699285716 0.0 -1.5194057016818971 -3.1985140016486606 -2.3589598516652788 10.0 0.08375755068951721 0.00500653542372124 0.020477674294977818 16.729643076661223 1.0 -1.076976031157057 -2.300462706638876 -1.6887193688979665 25.0 0.08476002890103196 0.005058860144610649 0.02070722415157274 16.75476816478694 1.3979400086720377 -1.0718089038777536 -2.295947326771197 -1.6838781153244753 50.0 0.08476002890103196 0.005058860144610649 0.02070722415157274 16.75476816478694 1.6989700043360187 -1.0718089038777536 -2.295947326771197 -1.6838781153244753 75.0 0.08476002890103196 0.005058860144610649 0.02070722415157274 16.75476816478694 1.8750612633917 -1.0718089038777536 -2.295947326771197 -1.6838781153244753 100.0 0.08476002890103196 0.005058860144610649 0.02070722415157274 16.75476816478694 2.0 -1.0718089038777536 -2.295947326771197 -1.6838781153244753 250.0 0.08476002890103196 0.005058860144610649 0.02070722415157274 16.75476816478694 2.3979400086720375 -1.0718089038777536 -2.295947326771197 -1.6838781153244753 500.0 0.08476002890103196 0.005058860144610649 0.02070722415157274 16.75476816478694 2.6989700043360187 -1.0718089038777536 -2.295947326771197 -1.6838781153244753 1000.0 0.08476002890103196 0.005058860144610649 0.02070722415157274 16.75476816478694 3.0 -1.0718089038777536 -2.295947326771197 -1.6838781153244753 2500.0 0.08476002890103196 0.005058860144610649 0.02070722415157274 16.75476816478694 3.3979400086720375 -1.0718089038777536 -2.295947326771197 -1.6838781153244753 5000.0 0.08476002890103196 0.005058860144610649 0.02070722415157274 16.75476816478694 3.6989700043360187 -1.0718089038777536 -2.295947326771197 -1.6838781153244753 10000.0 0.08476002890103196 0.005058860144610649 0.02070722415157274 16.75476816478694 4.0 -1.0718089038777536 -2.295947326771197 -1.6838781153244753 ==> prazosin_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 2.066731666865458e-08 3.431754717318597e-10 2.663177828684607e-09 60.22375831336511 -6.0 -7.684715906132503 -9.464483760660702 -8.574599833396602 5e-06 1.033365833432729e-07 1.7158773586592987e-09 1.3315889143423034e-08 60.22375831336511 -5.301029995663981 -6.985745901796484 -8.765513756324683 -7.875629829060584 1e-05 2.066731666865458e-07 3.4317547173185975e-09 2.663177828684607e-08 60.22375831336511 -5.0 -6.684715906132503 -8.464483760660702 -7.5745998333966025 5e-05 1.033365833432729e-06 1.715877358659299e-08 1.3315889143423034e-07 60.223758313365096 -4.301029995663981 -5.985745901796484 -7.765513756324683 -6.875629829060584 0.0001 2.066731666865458e-06 3.431754717318598e-08 2.6631778286846073e-07 60.223758313365096 -4.0 -5.684715906132503 -7.464483760660702 -6.5745998333966025 0.001 2.0667316668654583e-05 3.431754717318597e-07 2.663177828684607e-06 60.22375831336512 -3.0 -4.684715906132503 -6.464483760660702 -5.5745998333966025 0.01 0.0002066731666865458 3.4317547173185973e-06 2.663177828684607e-05 60.2237583133651 -2.0 -3.684715906132503 -5.464483760660702 -4.5745998333966025 0.1 0.002066731666865458 3.4317547173185976e-05 0.0002663177828684607 60.223758313365096 -1.0 -2.684715906132503 -4.464483760660702 -3.5745998333966025 1.0 0.03618448569389037 0.0006369352551528492 0.004800747298912193 56.810304345936956 0.0 -1.44147759581374 -3.1959047117131947 -2.318691153763467 10.0 0.07940598676863975 0.005570088123475498 0.021030890229204572 14.255786445097351 1.0 -1.1001467529561697 -2.254137933868212 -1.677142343412191 25.0 0.08068260567840171 0.005633767617241127 0.021320109079120936 14.321251986235144 1.3979400086720377 -1.0932200845113542 -2.2492010708453245 -1.6712105776783392 50.0 0.08068260567840171 0.005633767617241127 0.021320109079120936 14.321251986235144 1.6989700043360187 -1.0932200845113542 -2.2492010708453245 -1.6712105776783392 75.0 0.08068260567840171 0.005633767617241127 0.021320109079120936 14.321251986235144 1.8750612633917 -1.0932200845113542 -2.2492010708453245 -1.6712105776783392 100.0 0.08068260567840171 0.005633767617241127 0.021320109079120936 14.321251986235144 2.0 -1.0932200845113542 -2.2492010708453245 -1.6712105776783392 250.0 0.08068260567840171 0.005633767617241127 0.021320109079120936 14.321251986235144 2.3979400086720375 -1.0932200845113542 -2.2492010708453245 -1.6712105776783392 500.0 0.08068260567840171 0.005633767617241127 0.021320109079120936 14.321251986235144 2.6989700043360187 -1.0932200845113542 -2.2492010708453245 -1.6712105776783392 1000.0 0.08068260567840171 0.005633767617241127 0.021320109079120936 14.321251986235144 3.0 -1.0932200845113542 -2.2492010708453245 -1.6712105776783392 2500.0 0.08068260567840171 0.005633767617241127 0.021320109079120936 14.321251986235144 3.3979400086720375 -1.0932200845113542 -2.2492010708453245 -1.6712105776783392 5000.0 0.08068260567840171 0.005633767617241127 0.021320109079120936 14.321251986235144 3.6989700043360187 -1.0932200845113542 -2.2492010708453245 -1.6712105776783392 10000.0 0.08068260567840171 0.005633767617241127 0.021320109079120936 14.321251986235144 4.0 -1.0932200845113542 -2.2492010708453245 -1.6712105776783392 ==> trimethoprim_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 5.104864945187527e-08 4.754690060028978e-09 1.5579489918695505e-08 10.736483095086149 -6.0 -7.292015743162904 -8.322877787792022 -7.807446765477463 5e-06 2.552432472593764e-07 2.3773450300144886e-08 7.789744959347751e-08 10.736483095086152 -5.301029995663981 -6.593045738826885 -7.623907783456004 -7.1084767611414446 1e-05 5.104864945187528e-07 4.754690060028977e-08 1.5579489918695505e-07 10.736483095086152 -5.0 -6.292015743162904 -7.322877787792023 -6.807446765477463 5e-05 2.552432472593764e-06 2.377345030014489e-07 7.789744959347752e-07 10.736483095086152 -4.301029995663981 -5.593045738826885 -6.623907783456003 -6.1084767611414446 0.0001 5.104864945187528e-06 4.754690060028978e-07 1.5579489918695506e-06 10.736483095086152 -4.0 -5.292015743162904 -6.322877787792023 -5.807446765477463 0.001 5.104864945187527e-05 4.7546900600289765e-06 1.5579489918695504e-05 10.736483095086152 -3.0 -4.292015743162904 -5.322877787792023 -4.807446765477463 0.01 0.0005104864945187528 4.754690060028978e-05 0.00015579489918695504 10.73648309508615 -2.0 -3.292015743162904 -4.322877787792023 -3.8074467654774633 0.1 0.005104864945187528 0.00047546900600289784 0.0015579489918695504 10.73648309508615 -1.0 -2.292015743162904 -3.3228777877920224 -2.8074467654774633 1.0 0.05104864945187527 0.004754690060028978 0.015579489918695514 10.736483095086149 0.0 -1.2920157431629038 -2.3228777877920224 -1.807446765477463 10.0 0.5104864945187527 0.04754690060028977 0.1557948991869551 10.736483095086152 1.0 -0.2920157431629038 -1.3228777877920226 -0.8074467654774632 25.0 1.2762162362968819 0.11886725150072446 0.3894872479673878 10.73648309508615 1.3979400086720377 0.10592426550913381 -0.9249377791199848 -0.4095067568054255 50.0 2.5524324725937637 0.2377345030014489 0.7789744959347756 10.73648309508615 1.6989700043360187 0.406954261173115 -0.6239077834560036 -0.10847676114144429 75.0 3.828648708890645 0.35660175450217335 1.1684617439021634 10.736483095086149 1.8750612633917 0.5830455202287962 -0.4478165244003224 0.06761449791423693 100.0 5.104864945187527 0.4754690060028978 1.5579489918695513 10.73648309508615 2.0 0.7079842568370962 -0.32287778779202236 0.1925532345225369 250.0 18.813974670141338 2.133841406765365 6.336090133274805 8.816950786732065 2.3979400086720375 1.274480554984693 0.3291621382720765 0.8018213466283848 500.0 22.68328811834695 3.3422357040902937 8.7070600914032 6.7868606904613875 2.6989700043360187 1.355706009133931 0.5240370743353961 0.9398715417346636 1000.0 27.97362193847479 5.799146913206319 12.73668494215456 4.82374776103203 3.0 1.4467487011250555 0.7633641111256304 1.105056406125343 2500.0 44.77560696277936 13.501647576352548 24.587485947707716 3.316306895848886 3.3979400086720375 1.6510414817080965 1.1303867677290187 1.3907141247185577 5000.0 69.14166655422424 27.520763998540172 43.62145673524169 2.5123454624258192 3.6989700043360187 1.8397398433374346 1.4396604860948914 1.6397001647161629 10000.0 86.87343676738737 38.385294214051235 57.746536084010614 2.263195803136157 4.0 1.9388870028136433 1.5841648737184109 1.761525938266027 ==> trimethoprim_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.821706816147854e-08 4.7147018944986745e-09 9.267580362377997e-09 3.863885473381685 -6.0 -7.739521516701472 -8.32654576202891 -8.033033639365192 5e-06 9.108534080739268e-08 2.3573509472493377e-08 4.633790181188998e-08 3.863885473381684 -5.301029995663981 -7.040551512365453 -7.627575757692893 -7.334063635029173 1e-05 1.8217068161478536e-07 4.714701894498675e-08 9.267580362377997e-08 3.863885473381684 -5.0 -6.739521516701472 -7.326545762028911 -7.0330336393651915 5e-05 9.108534080739268e-07 2.357350947249338e-07 4.633790181188998e-07 3.8638854733816834 -4.301029995663981 -6.040551512365453 -6.627575757692893 -6.334063635029173 0.0001 1.8217068161478536e-06 4.714701894498676e-07 9.267580362377997e-07 3.8638854733816834 -4.0 -5.739521516701472 -6.326545762028911 -6.0330336393651915 0.001 1.8217068161478535e-05 4.714701894498675e-06 9.267580362377997e-06 3.8638854733816843 -3.0 -4.739521516701472 -5.326545762028911 -5.0330336393651915 0.01 0.00018217068161478534 4.7147018944986755e-05 9.267580362377998e-05 3.8638854733816834 -2.0 -3.7395215167014717 -4.326545762028911 -4.0330336393651915 0.1 0.0018217068161478537 0.0004714701894498675 0.0009267580362377997 3.8638854733816843 -1.0 -2.7395215167014717 -3.3265457620289114 -3.0330336393651915 1.0 0.018217068161478535 0.004714701894498675 0.009267580362377998 3.8638854733816843 0.0 -1.7395215167014717 -2.3265457620289114 -2.0330336393651915 10.0 0.18217068161478536 0.04714701894498675 0.09267580362378003 3.8638854733816843 1.0 -0.7395215167014716 -1.3265457620289112 -1.0330336393651913 25.0 0.45542670403696345 0.11786754736246688 0.23168950905945 3.8638854733816843 1.3979400086720377 -0.341581508029434 -0.9286057533568736 -0.6350936306931538 50.0 0.9108534080739269 0.23573509472493376 0.46337901811890003 3.8638854733816843 1.6989700043360187 -0.04055151236545278 -0.6275757576928924 -0.3340636350291726 75.0 1.36628011211089 0.3536026420874006 0.69506852717835 3.863885473381684 1.8750612633917 0.1355397466902284 -0.4514844986372112 -0.15797237597349137 100.0 1.8217068161478538 0.4714701894498675 0.9267580362378001 3.8638854733816843 2.0 0.2604784832985284 -0.32654576202891117 -0.0330336393651914 250.0 8.020432300782156 2.1158971064826817 4.1195156873066034 3.790558754586492 2.3979400086720375 0.9041977773595223 0.3254945446612141 0.6148461610103682 500.0 12.591059640602293 3.314134447992838 6.459757309036648 3.799200013815946 2.6989700043360187 1.1000622810769811 0.5203701229236897 0.8102162020003354 1000.0 20.8496315189948 5.750409270566565 10.949607955297967 3.625764800031454 3.0 1.3190983839773371 0.7596987555806358 1.0393985697789865 2500.0 42.16812104579525 13.388399668751983 23.76054834892113 3.1496013032994563 3.3979400086720375 1.6249842498736977 1.126728668381198 1.3758564591274478 5000.0 69.9579278141901 27.291650496637914 43.695163523826075 2.5633454386647774 3.6989700043360187 1.8448369369960202 1.4360298009651355 1.640433368980578 10000.0 87.25507176333667 38.069695382740825 57.63483324023257 2.2919823992837727 4.0 1.9407906800416979 1.5805794017914088 1.7606850409165533 ==> trimethoprim_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.3125939497295204e-07 3.2488677245221488e-09 2.0650530546887388e-08 40.401581751764915 -6.0 -6.881869601911443 -8.488267970304618 -7.6850687861080305 5e-06 6.562969748647602e-07 1.6244338622610746e-08 1.0325265273443671e-07 40.40158175176491 -5.301029995663981 -6.182899597575425 -7.7892979659686 -6.986098781772013 1e-05 1.3125939497295204e-06 3.248867724522149e-08 2.0650530546887345e-07 40.40158175176491 -5.0 -5.881869601911443 -7.488267970304618 -6.685068786108031 5e-05 6.562969748647601e-06 1.6244338622610744e-07 1.0325265273443672e-06 40.40158175176491 -4.301029995663981 -5.182899597575425 -6.7892979659686 -5.986098781772013 0.0001 1.3125939497295202e-05 3.248867724522149e-07 2.0650530546887344e-06 40.40158175176491 -4.0 -4.881869601911443 -6.488267970304618 -5.685068786108031 0.001 0.00013125939497295205 3.248867724522149e-06 2.065053054688739e-05 40.401581751764915 -3.0 -3.881869601911443 -5.488267970304618 -4.6850687861080305 0.01 0.0013125939497295204 3.248867724522149e-05 0.00020650530546887389 40.40158175176491 -2.0 -2.881869601911443 -4.488267970304618 -3.6850687861080305 0.1 0.013125939497295206 0.0003248867724522149 0.0020650530546887386 40.401581751764915 -1.0 -1.881869601911443 -3.4882679703046184 -2.6850687861080305 1.0 0.13125939497295205 0.0032488677245221483 0.020650530546887376 40.40158175176492 0.0 -0.8818696019114429 -2.4882679703046184 -1.6850687861080307 10.0 1.3125939497295205 0.03248867724522148 0.20650530546887377 40.40158175176492 1.0 0.11813039808855703 -1.4882679703046184 -0.6850687861080307 25.0 3.281484874323801 0.0812216931130537 0.5162632636721843 40.40158175176492 1.3979400086720377 0.5160704067605946 -1.090327961632581 -0.28712877743599313 50.0 6.562969748647602 0.1624433862261074 1.0325265273443687 40.40158175176492 1.6989700043360187 0.8171004024245758 -0.7892979659685997 0.013901218227988047 75.0 9.844454622971401 0.24366507933916118 1.5487897910165533 40.4015817517649 1.8750612633917 0.993191661480257 -0.6132067069129182 0.1899924772836694 100.0 13.125939497295205 0.3248867724522148 2.065053054688738 40.40158175176492 2.0 1.118130398088557 -0.48826797030461844 0.3149312138919693 250.0 53.051303165639744 1.4560328768068314 8.788881701708004 36.435511869748765 2.3979400086720375 1.7246960564879745 0.1631711813331923 0.9439336189105834 500.0 73.51644104647106 2.275633056825779 12.934312639855785 32.30592947573771 2.6989700043360187 1.8663844745574527 0.35710223389022816 1.1117433542238404 1000.0 90.59389084125978 3.9297391606810024 18.86823681633657 23.053410706668977 3.0 1.9570989122089792 0.5943637247173152 1.2757313184631474 2500.0 102.61213532047994 9.013486388395771 30.41205492884969 11.384289152817253 3.3979400086720375 2.0111987252111265 0.9548928072250114 1.483045766218069 5000.0 114.94062456812775 17.906103182198937 45.36671338485172 6.419075295086768 3.6989700043360187 2.0604735526876605 1.2530010827443216 1.656737317715991 10000.0 123.68473039729736 24.51626102931157 55.06620684013173 5.045007892900972 4.0 2.092316086746932 1.3894542367209488 1.7408851617339405 ==> trimethoprim_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 1.8359253134191794e-08 3.471560173231635e-09 7.983436101763325e-09 5.288473256421011 -6.0 -7.7361449901444015 -8.45947530263097 -8.097810146387687 5e-06 9.179626567095897e-08 1.735780086615818e-08 3.99171805088167e-08 5.28847325642101 -5.301029995663981 -7.037174985808383 -7.760505298294952 -7.398840142051667 1e-05 1.8359253134191794e-07 3.471560173231636e-08 7.983436101763341e-08 5.28847325642101 -5.0 -6.7361449901444015 -7.45947530263097 -7.097810146387686 5e-05 9.179626567095898e-07 1.735780086615818e-07 3.99171805088167e-07 5.2884732564210095 -4.301029995663981 -6.037174985808383 -6.760505298294952 -6.398840142051667 0.0001 1.8359253134191796e-06 3.471560173231636e-07 7.983436101763341e-07 5.2884732564210095 -4.0 -5.7361449901444015 -6.45947530263097 -6.097810146387686 0.001 1.8359253134191795e-05 3.4715601732316358e-06 7.983436101763342e-06 5.28847325642101 -3.0 -4.7361449901444015 -5.45947530263097 -5.097810146387686 0.01 0.00018359253134191795 3.4715601732316354e-05 7.983436101763341e-05 5.28847325642101 -2.0 -3.7361449901444015 -4.45947530263097 -4.097810146387686 0.1 0.001835925313419179 0.00034715601732316357 0.0007983436101763341 5.288473256421009 -1.0 -2.7361449901444015 -3.4594753026309704 -3.097810146387686 1.0 0.018359253134191792 0.0034715601732316355 0.00798343610176334 5.2884732564210095 0.0 -1.7361449901444013 -2.4594753026309704 -2.097810146387686 10.0 0.18359253134191794 0.03471560173231636 0.07983436101763346 5.2884732564210095 1.0 -0.7361449901444013 -1.4594753026309701 -1.0978101463876857 25.0 0.45898132835479477 0.0867890043307909 0.19958590254408362 5.288473256421009 1.3979400086720377 -0.3382049814723638 -1.0615352939589324 -0.6998701377156481 50.0 0.9179626567095895 0.1735780086615818 0.39917180508816724 5.288473256421009 1.6989700043360187 -0.037174985808382556 -0.7605052982949514 -0.39884014205166696 75.0 1.3769439850643843 0.26036701299237264 0.5987577076322508 5.2884732564210095 1.8750612633917 0.1389162732472987 -0.5844140392392703 -0.22274888299598572 100.0 1.835925313419179 0.3471560173231636 0.7983436101763345 5.288473256421009 2.0 0.2638550098555986 -0.45947530263097014 -0.09781014638768573 250.0 8.235131452312586 1.5590636109772065 3.583168120380961 5.282100995963137 2.3979400086720375 0.9156705359354451 0.19286383509442398 0.5542671855149346 500.0 12.751864308346546 2.444703737550368 5.583415651315057 5.216118465595392 2.6989700043360187 1.1055736827808742 0.3882262364891174 0.7468999596349958 1000.0 21.552713556243017 4.252919938283409 9.574025548715495 5.067744953821601 3.0 1.3335019570170374 0.6286872071464231 0.9810945820817303 2500.0 45.38227699002614 9.997234360777822 21.30017039591529 4.539483156269154 3.3979400086720375 1.6568862821922705 0.9998798732025523 1.3283830776974115 5000.0 78.04772030883551 20.82585753363443 40.316382575533176 3.747635370249985 3.6989700043360187 1.8923602223023146 1.318602893126022 1.6054815577141683 10000.0 97.81076186472703 29.63709276516367 53.84075243545773 3.300281935200363 4.0 1.990386641713291 1.47183559951067 1.7311111206119805 ==> trimethoprim_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 2.9099330570216585e-08 3.740919307236027e-09 1.0433515589568393e-08 7.778657645442928 -6.0 -7.536117001839009 -8.427021659564447 -7.981569330701728 5e-06 1.454966528510829e-07 1.8704596536180135e-08 5.216757794784196e-08 7.7786576454429275 -5.301029995663981 -6.83714699750299 -7.728051655228428 -7.282599326365709 1e-05 2.909933057021658e-07 3.740919307236027e-08 1.0433515589568393e-07 7.7786576454429275 -5.0 -6.536117001839009 -7.4270216595644465 -6.981569330701728 5e-05 1.454966528510829e-06 1.870459653618013e-07 5.216757794784196e-07 7.778657645442929 -4.301029995663981 -5.83714699750299 -6.728051655228428 -6.282599326365709 0.0001 2.909933057021658e-06 3.740919307236026e-07 1.0433515589568392e-06 7.778657645442929 -4.0 -5.536117001839009 -6.4270216595644465 -5.981569330701728 0.001 2.9099330570216583e-05 3.7409193072360273e-06 1.0433515589568393e-05 7.7786576454429275 -3.0 -4.536117001839009 -5.4270216595644465 -4.981569330701728 0.01 0.0002909933057021658 3.740919307236027e-05 0.00010433515589568393 7.7786576454429275 -2.0 -3.5361170018390085 -4.4270216595644465 -3.9815693307017277 0.1 0.002909933057021658 0.00037409193072360274 0.0010433515589568392 7.778657645442927 -1.0 -2.5361170018390085 -3.4270216595644465 -2.9815693307017277 1.0 0.029099330570216582 0.0037409193072360267 0.010433515589568398 7.778657645442928 0.0 -1.5361170018390085 -2.4270216595644465 -1.9815693307017275 10.0 0.29099330570216586 0.03740919307236027 0.10433515589568398 7.778657645442928 1.0 -0.5361170018390085 -1.4270216595644465 -0.9815693307017275 25.0 0.7274832642554145 0.09352298268090067 0.2608378897392099 7.7786576454429275 1.3979400086720377 -0.13817699316697094 -1.029081650892409 -0.58362932202969 50.0 1.454966528510829 0.18704596536180135 0.5216757794784198 7.7786576454429275 1.6989700043360187 0.16285300249701024 -0.7280516552284277 -0.2825993263657087 75.0 2.1824497927662434 0.280568948042702 0.7825136692176295 7.7786576454429275 1.8750612633917 0.3389442615526915 -0.5519603961727466 -0.1065080673100276 100.0 2.909933057021658 0.3740919307236027 1.0433515589568396 7.7786576454429275 2.0 0.46388299816099143 -0.4270216595644466 0.018430669298272445 250.0 12.604146524165053 1.67744407154687 4.598124711648082 7.51389971085118 2.3979400086720375 1.1005134432377974 0.22464804906547453 0.662580746151636 500.0 19.895419413320816 2.623871847998033 7.225166496540134 7.582466128633784 2.6989700043360187 1.2987530988968792 0.4189426199313621 0.8588478594141207 1000.0 32.432341193642365 4.539471055529159 12.133658727341295 7.144519878398427 3.0 1.5109783002234003 0.6570052513047063 1.0839917757640534 2500.0 62.22970982466015 10.474076421370542 25.530349319647073 5.941307598032337 3.3979400086720375 1.7939977758865644 1.0201157382935984 1.4070567570900814 5000.0 93.2482219608631 21.03890654239487 44.292670128127185 4.432180055221093 3.6989700043360187 1.9696405595161384 1.3230231644292083 1.6463318619726732 10000.0 108.78884965737207 29.069821713302222 56.23586456999703 3.7423294415180663 4.0 2.0365843845125795 1.4634423682284092 1.7500133763704944 ==> warfarin_(scenario_1).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 5.862411512017328e-07 3.0116758191144356e-07 4.20186660812081e-07 1.9465612715717635 -6.0 -6.231923699523363 -6.521191778004829 -6.376557738764096 5e-06 2.9312057560086644e-06 1.5058379095572177e-06 2.1009333040604046e-06 1.946561271571764 -5.301029995663981 -5.532953695187344 -5.822221773668811 -5.677587734428077 1e-05 5.862411512017329e-06 3.0116758191144354e-06 4.20186660812081e-06 1.946561271571764 -5.0 -5.231923699523363 -5.521191778004829 -5.376557738764096 5e-05 2.931205756008665e-05 1.5058379095572178e-05 2.1009333040604045e-05 1.9465612715717642 -4.301029995663981 -4.532953695187344 -4.822221773668811 -4.677587734428077 0.0001 5.86241151201733e-05 3.0116758191144356e-05 4.2018666081208096e-05 1.9465612715717642 -4.0 -4.231923699523363 -4.521191778004829 -4.376557738764096 0.001 0.0005862411512017328 0.00030116758191144354 0.00042018666081208096 1.9465612715717637 -3.0 -3.231923699523363 -3.5211917780048294 -3.376557738764096 0.01 0.005862411512017329 0.003011675819114435 0.00420186660812081 1.9465612715717644 -2.0 -2.2319236995233624 -2.5211917780048294 -2.376557738764096 0.1 0.05862411512017329 0.030116758191144358 0.0420186660812081 1.9465612715717637 -1.0 -1.2319236995233627 -1.5211917780048294 -1.3765577387640962 1.0 0.5862411512017328 0.3011675819114436 0.42018666081208106 1.9465612715717633 0.0 -0.23192369952336267 -0.5211917780048294 -0.37655773876409604 10.0 5.862411512017329 3.0116758191144353 4.20186660812081 1.946561271571764 1.0 0.7680763004766373 0.4788082219951705 0.6234422612359038 25.0 20.75102241100069 10.769703493406597 14.949326357783244 1.9267960741634933 1.3979400086720377 1.3170394994344707 1.0322037466638143 1.1746216230491426 50.0 34.75370582032707 18.380279085156335 25.2741530465619 1.8908149141431532 1.6989700043360187 1.5410011206242358 1.2643521014039112 1.4026766110140736 75.0 48.13206374090276 26.046016817765718 35.40689963367768 1.8479625532635138 1.8750612633917 1.6824344831623226 1.4157413166439243 1.5490878999031235 100.0 60.84519317185709 33.76773400996256 45.327743147128565 1.8018737400000193 2.0 1.7842262742440442 1.5285019182016564 1.6563640962228503 250.0 129.41340644571807 81.32935509599461 102.59195332483972 1.5912262711657914 2.3979400086720375 2.1119792689432457 1.910247328560306 2.011113298751776 500.0 158.9032015822728 104.05223361263683 128.58550872020763 1.5271483952361258 2.6989700043360187 2.201132647462302 2.0172514073273784 2.1091920273948404 1000.0 158.9032015822728 104.05223361263683 128.58550872020763 1.5271483952361258 3.0 2.201132647462302 2.0172514073273784 2.1091920273948404 2500.0 158.9032015822728 104.05223361263683 128.58550872020763 1.5271483952361258 3.3979400086720375 2.201132647462302 2.0172514073273784 2.1091920273948404 5000.0 158.9032015822728 104.05223361263683 128.58550872020763 1.5271483952361258 3.6989700043360187 2.201132647462302 2.0172514073273784 2.1091920273948404 10000.0 158.9032015822728 104.05223361263683 128.58550872020763 1.5271483952361258 4.0 2.201132647462302 2.0172514073273784 2.1091920273948404 ==> warfarin_(scenario_2).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 4.760998800897988e-07 3.1160075639454223e-07 3.851663053219119e-07 1.5279163170161605 -6.0 -6.322301927906596 -6.506401496771049 -6.4143517123388225 5e-06 2.3804994004489947e-06 1.5580037819727113e-06 1.9258315266095593e-06 1.527916317016161 -5.301029995663981 -5.623331923570578 -5.80743149243503 -5.715381708002804 1e-05 4.760998800897989e-06 3.1160075639454225e-06 3.851663053219119e-06 1.527916317016161 -5.0 -5.322301927906596 -5.506401496771049 -5.4143517123388225 5e-05 2.3804994004489946e-05 1.5580037819727113e-05 1.9258315266095593e-05 1.5279163170161607 -4.301029995663981 -4.623331923570578 -4.80743149243503 -4.715381708002804 0.0001 4.760998800897989e-05 3.116007563945423e-05 3.851663053219119e-05 1.5279163170161607 -4.0 -4.322301927906596 -4.506401496771049 -4.4143517123388225 0.001 0.00047609988008979895 0.00031160075639454225 0.0003851663053219119 1.527916317016161 -3.0 -3.322301927906597 -3.5064014967710486 -3.4143517123388225 0.01 0.004760998800897989 0.003116007563945423 0.003851663053219119 1.5279163170161607 -2.0 -2.322301927906597 -2.506401496771048 -2.4143517123388225 0.1 0.0476099880089799 0.031160075639454225 0.03851663053219119 1.5279163170161612 -1.0 -1.3223019279065966 -1.5064014967710484 -1.4143517123388225 1.0 0.47609988008979887 0.3116007563945423 0.3851663053219118 1.5279163170161603 0.0 -0.3223019279065968 -0.5064014967710484 -0.4143517123388226 10.0 4.760998800897989 3.1160075639454226 3.8516630532191183 1.5279163170161607 1.0 0.6776980720934033 0.49359850322895155 0.5856482876611775 25.0 16.932326909492573 11.149306924431269 13.739858429355797 1.518688742202359 1.3979400086720377 1.2287166447309918 1.0472478711285418 1.137982257929767 50.0 28.66925411033986 19.04338999747584 23.36578239563014 1.5054700929897413 1.6989700043360187 1.4574163940285425 1.279744261598254 1.3685803278133983 75.0 40.28915280093153 27.008346539308885 32.987018668299285 1.4917297044561133 1.8750612633917 1.6051881351533583 1.4314979973368558 1.518343066245107 100.0 51.78787097197478 35.045452160494094 42.601987684170105 1.477734421425272 2.0 1.7142280572984725 1.544631667673557 1.6294298624860146 250.0 117.72738881884219 84.8587100899835 99.95095976241996 1.3873341781180153 2.3979400086720375 2.070877511519227 1.928696425909739 1.999786968714483 500.0 147.50021051033062 108.83273073307815 126.69984488365861 1.3552927461876139 2.6989700043360187 2.168792640133909 2.036759526235778 2.1027760831848434 1000.0 147.50021051033062 108.83273073307815 126.69984488365861 1.3552927461876139 3.0 2.168792640133909 2.036759526235778 2.1027760831848434 2500.0 147.50021051033062 108.83273073307815 126.69984488365861 1.3552927461876139 3.3979400086720375 2.168792640133909 2.036759526235778 2.1027760831848434 5000.0 147.50021051033062 108.83273073307815 126.69984488365861 1.3552927461876139 3.6989700043360187 2.168792640133909 2.036759526235778 2.1027760831848434 10000.0 147.50021051033062 108.83273073307815 126.69984488365861 1.3552927461876139 4.0 2.168792640133909 2.036759526235778 2.1027760831848434 ==> warfarin_(scenario_3).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 5.489105390104323e-07 2.392476370969676e-07 3.623886717819266e-07 2.2943195831353504 -6.0 -6.260498430741183 -6.621152342791728 -6.4408253867664556 5e-06 2.7445526950521624e-06 1.1962381854848383e-06 1.8119433589096328e-06 2.2943195831353504 -5.301029995663981 -5.5615284264051645 -5.922182338455709 -5.741855382430437 1e-05 5.489105390104325e-06 2.3924763709696765e-06 3.623886717819266e-06 2.2943195831353504 -5.0 -5.260498430741183 -5.621152342791728 -5.4408253867664556 5e-05 2.744552695052162e-05 1.1962381854848384e-05 1.811943358909633e-05 2.2943195831353504 -4.301029995663981 -4.5615284264051645 -4.922182338455709 -4.741855382430437 0.0001 5.489105390104324e-05 2.3924763709696767e-05 3.623886717819266e-05 2.2943195831353504 -4.0 -4.260498430741183 -4.621152342791728 -4.4408253867664556 0.001 0.0005489105390104323 0.00023924763709696765 0.00036238867178192664 2.29431958313535 -3.0 -3.2604984307411833 -3.6211523427917283 -3.4408253867664556 0.01 0.005489105390104325 0.002392476370969677 0.003623886717819266 2.2943195831353504 -2.0 -2.2604984307411833 -2.621152342791728 -2.4408253867664556 0.1 0.05489105390104324 0.023924763709696772 0.03623886717819266 2.29431958313535 -1.0 -1.2604984307411833 -1.6211523427917278 -1.4408253867664556 1.0 0.5489105390104324 0.2392476370969677 0.3623886717819265 2.29431958313535 0.0 -0.26049843074118334 -0.6211523427917279 -0.44082538676645566 10.0 5.489105390104323 2.392476370969677 3.623886717819265 2.2943195831353496 1.0 0.7395015692588166 0.37884765720827207 0.5591746132335443 25.0 19.462844122108027 8.586512479361694 12.927410952636723 2.266676275017172 1.3979400086720377 1.2892063043950024 0.9338168054475049 1.1115115549212535 50.0 32.82983672532885 14.727358640788546 21.988560197803963 2.2291734401309484 1.6989700043360187 1.5162687228309226 1.1681248628919807 1.3421967928614515 75.0 45.9557322811379 20.978772963289824 31.04987719601675 2.190582469315749 1.8750612633917 1.6623396907557944 1.3217800829587596 1.492059886857277 100.0 58.83367916979963 27.344270321962217 40.10940073417452 2.151590752909794 2.0 1.7696260078839667 1.4368663387776355 1.6032461733308012 250.0 129.77678051285727 68.14407743699716 94.03998607396927 1.9044469511358904 2.3979400086720375 2.113196996029826 1.8334281162498876 1.9733125561398568 500.0 161.13843009778074 88.64236523483724 119.51439902411659 1.8178489446990962 2.6989700043360187 2.2071991281848313 1.9476413357725952 2.077420231978713 1000.0 161.13843009778074 88.64236523483724 119.51439902411659 1.8178489446990962 3.0 2.2071991281848313 1.9476413357725952 2.077420231978713 2500.0 161.13843009778074 88.64236523483724 119.51439902411659 1.8178489446990962 3.3979400086720375 2.2071991281848313 1.9476413357725952 2.077420231978713 5000.0 161.13843009778074 88.64236523483724 119.51439902411659 1.8178489446990962 3.6989700043360187 2.2071991281848313 1.9476413357725952 2.077420231978713 10000.0 161.13843009778074 88.64236523483724 119.51439902411659 1.8178489446990962 4.0 2.2071991281848313 1.9476413357725952 2.077420231978713 ==> warfarin_(scenario_4).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 4.635715294975535e-07 2.975118151355094e-07 3.713731374049035e-07 1.5581617465726798 -6.0 -6.333883244325764 -6.526495782384964 -6.430189513355364 5e-06 2.317857647487768e-06 1.4875590756775472e-06 1.856865687024517e-06 1.5581617465726796 -5.301029995663981 -5.634913239989745 -5.827525778048945 -5.731219509019345 1e-05 4.635715294975536e-06 2.9751181513550944e-06 3.7137313740490345e-06 1.5581617465726796 -5.0 -5.333883244325763 -5.526495782384964 -5.430189513355364 5e-05 2.317857647487768e-05 1.4875590756775472e-05 1.856865687024517e-05 1.5581617465726798 -4.301029995663981 -4.634913239989745 -4.827525778048945 -4.731219509019345 0.0001 4.635715294975536e-05 2.9751181513550945e-05 3.713731374049035e-05 1.5581617465726798 -4.0 -4.333883244325763 -4.526495782384964 -4.430189513355364 0.001 0.0004635715294975535 0.00029751181513550936 0.00037137313740490346 1.5581617465726798 -3.0 -3.3338832443257638 -3.5264957823849636 -3.430189513355364 0.01 0.004635715294975536 0.002975118151355094 0.003713731374049035 1.5581617465726798 -2.0 -2.3338832443257638 -2.5264957823849636 -2.430189513355364 0.1 0.04635715294975536 0.02975118151355094 0.03713731374049038 1.55816174657268 -1.0 -1.3338832443257638 -1.5264957823849634 -1.4301895133553635 1.0 0.46357152949755354 0.29751181513550934 0.3713731374049037 1.55816174657268 0.0 -0.33388324432576383 -0.5264957823849635 -0.4301895133553637 10.0 4.635715294975536 2.975118151355094 3.7137313740490367 1.5581617465726798 1.0 0.6661167556742362 0.47350421761503647 0.5698104866446363 25.0 16.50577241195183 10.65362802780255 13.26070735626498 1.5493099973902844 1.3979400086720377 1.2176358525923694 1.027497529290098 1.1225666909412337 50.0 27.96765510437713 18.216068483307808 22.57123657885999 1.5353288295992702 1.6989700043360187 1.4466560552910719 1.2604546503402208 1.3535553528156463 75.0 39.3286214543505 25.86298813243707 31.892878044149242 1.5206526505351863 1.8750612633917 1.5947087237994944 1.4126787005311439 1.503693712165319 100.0 50.58289857063106 33.59553675376322 41.223289874068925 1.5056434115452848 2.0 1.7040037122595146 1.5262815841766189 1.6151426482180669 250.0 115.45259714047401 81.85350213916367 97.21213610969461 1.4104784049946533 2.3979400086720375 2.0624037069464825 1.9130372656315973 1.9877204862890399 500.0 144.78393467491458 105.25407732646455 123.44674744967259 1.3755660431646846 2.6989700043360187 2.1607203749197526 2.022238928508525 2.0914796517141387 1000.0 144.78393467491458 105.25407732646455 123.44674744967259 1.3755660431646846 3.0 2.1607203749197526 2.022238928508525 2.0914796517141387 2500.0 144.78393467491458 105.25407732646455 123.44674744967259 1.3755660431646846 3.3979400086720375 2.1607203749197526 2.022238928508525 2.0914796517141387 5000.0 144.78393467491458 105.25407732646455 123.44674744967259 1.3755660431646846 3.6989700043360187 2.1607203749197526 2.022238928508525 2.0914796517141387 10000.0 144.78393467491458 105.25407732646455 123.44674744967259 1.3755660431646846 4.0 2.1607203749197526 2.022238928508525 2.0914796517141387 ==> warfarin_(scenario_5).txt <== dose (mg) max central concentration (mg l-1) min central concentration (mg l-1) mid central concentration (mg l-1) max/min central ratio log10(dose (mg)) log10(max central concentration (mg l-1)) log10(min central concentration (mg l-1)) log10(mid central concentration (mg l-1)) 1e-06 4.959214282051664e-07 2.799317635761656e-07 3.725911432021474e-07 1.771579694528781 -6.0 -6.304587125929088 -6.552947819778973 -6.42876747285403 5e-06 2.4796071410258327e-06 1.3996588178808284e-06 1.8629557160107369e-06 1.771579694528781 -5.301029995663981 -5.6056171215930695 -5.853977815442954 -5.7297974685180115 1e-05 4.9592142820516654e-06 2.799317635761657e-06 3.7259114320214746e-06 1.771579694528781 -5.0 -5.304587125929088 -5.552947819778972 -5.42876747285403 5e-05 2.4796071410258323e-05 1.399658817880828e-05 1.8629557160107368e-05 1.7715796945287812 -4.301029995663981 -4.6056171215930695 -4.8539778154429545 -4.7297974685180115 0.0001 4.9592142820516646e-05 2.799317635761656e-05 3.725911432021474e-05 1.7715796945287812 -4.0 -4.304587125929088 -4.552947819778973 -4.42876747285403 0.001 0.0004959214282051665 0.0002799317635761656 0.00037259114320214743 1.7715796945287814 -3.0 -3.3045871259290878 -3.552947819778973 -3.4287674728540303 0.01 0.004959214282051665 0.0027993176357616564 0.0037259114320214743 1.7715796945287812 -2.0 -2.3045871259290878 -2.552947819778973 -2.4287674728540303 0.1 0.049592142820516646 0.02799317635761657 0.037259114320214747 1.7715796945287807 -1.0 -1.304587125929088 -1.5529478197789728 -1.4287674728540303 1.0 0.4959214282051665 0.2799317635761656 0.37259114320214737 1.7715796945287812 0.0 -0.304587125929088 -0.5529478197789728 -0.4287674728540304 10.0 4.959214282051664 2.799317635761656 3.7259114320214723 1.771579694528781 1.0 0.6954128740709119 0.44705218022102716 0.5712325271459695 25.0 17.62975952367864 10.02965185559002 13.297381333189977 1.7577638563648355 1.3979400086720377 1.2462463884052961 1.0012858582626643 1.1237661233339802 50.0 29.82166428236019 17.162471571465645 22.623294752528846 1.7376089544085096 1.6989700043360187 1.4745318768257736 1.2345798308644285 1.354555853845101 75.0 41.864217365247896 24.38739820702873 31.952454358185193 1.7166331975988378 1.8750612633917 1.621842976659056 1.387165469661704 1.50450422316038 100.0 53.75121881465551 31.706474252399378 41.282703828382665 1.695275809816284 2.0 1.7303883163732812 1.5011479513345782 1.6157681338539298 250.0 121.14507425827327 77.71749192289404 97.03139352892832 1.5587877485607113 2.3979400086720375 2.0833057604797913 1.890518776724155 1.9869122686019731 500.0 151.37081802707402 100.25731992681658 123.19104078838004 1.5098231045630188 2.6989700043360187 2.180042157915908 2.0011160908959087 2.0905791244059087 1000.0 151.37081802707402 100.25731992681658 123.19104078838004 1.5098231045630188 3.0 2.180042157915908 2.0011160908959087 2.0905791244059087 2500.0 151.37081802707402 100.25731992681658 123.19104078838004 1.5098231045630188 3.3979400086720375 2.180042157915908 2.0011160908959087 2.0905791244059087 5000.0 151.37081802707402 100.25731992681658 123.19104078838004 1.5098231045630188 3.6989700043360187 2.180042157915908 2.0011160908959087 2.0905791244059087 10000.0 151.37081802707402 100.25731992681658 123.19104078838004 1.5098231045630188 4.0 2.180042157915908 2.0011160908959087 2.0905791244059087